Patent application number | Description | Published |
20100314981 | IMMOBILIZATION DEVICE FOR LOCKING A FURNITURE PART MOVABLY SUPPORTED IN OR ON A FURNITURE PART - The invention relates to an immobilization device for locking a furniture part that is movably supported in or on a piece of furniture, particularly a drawer, in a closed end position, comprising at least one locking unit, which has a receiving element for an engagement element and a blocking mechanism for the releasable fixation of the receiving element in a position that locks the engagement element when the movable furniture part is in the closed end position, wherein the receiving element or the engagement element is disposed on the furniture and the other element is disposed on the moved furniture part, wherein the locking unit has an overload safety mechanism, which comprises at least two parts connected movably to each other and allows damage-free opening of the movable furniture part even if the receiving element is fixed in a position that locks the engagement element by means of the blocking mechanism. | 12-16-2010 |
20100320888 | LOCKABLE EJECTOR DEVICE FOR A FURNITURE PART MOVABLY SUPPORTED IN PIECE OF FURNITURE - The invention relates to a lockable ejector device for a furniture part that is movably supported in a piece of furniture, comprising a fixing device for locking the movable furniture part in place in a closed end position, and at least one ejector element for moving the movable furniture part from the closed end position into an open position, wherein the fixing device comprises at least two locking units, which are coupled to each other and each have a receiving element for an engagement element, wherein at least two locking units are operatively connected to each other by way of a synchronization mechanism, which has at least two coupling elements, each associated with different locking units, and at least one synchronization unit, wherein the coupling elements are coupled by way of the synchronization unit with respect to the movements thereof | 12-23-2010 |
20100327719 | IMMOBILIZATION DEVICE FOR LOCKING A FURNITURE PART MOVABLY SUPPORTED IN OR ON AN ARTICLE OF FURNITURE - The invention relates to an immobilization device for locking a furniture part that is movably supported in or on a piece of furniture, particularly a drawer, in a closed end position, comprising at least one locking element, which has a receiving element for an engagement element, wherein the receiving element or the engagement element is disposed on the piece of furniture and the other element is disposed on the movable furniture part, and the two elements are operatively connected at least in the closed end position of the movable furniture part, wherein the relative position of the receiving element to the engagement element in the depth of the piece of furniture can be varied in a linear fashion by means of an adjusting unit, which is configured to convert a rotational movement into a translatory movement. | 12-30-2010 |
Patent application number | Description | Published |
20100093058 | High Transgene Expression Of A Pseudotyped Adeno-Associated Virus Type - The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permits selective targeting of desired cells. | 04-15-2010 |
20100143458 | GLUTAMIC ACID DECARBOXYLASE (GAD) BASED DELIVERY SYSTEM - The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus. | 06-10-2010 |
20110207802 | GLUTAMIC ACID DECARBOXYLASE (GAD) BASED DELIVERY SYSTEM - The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus. | 08-25-2011 |
20140057837 | METHODS AND COMPOSITIONS FOR THE "BROWNING" OF WHITE FAT - Methods for increasing the amount of brown adipose tissue in a subject, of increasing the ratio of brown fat to white fat in a subject, or for effecting a change in white adipose tissue to become brown adipose tissue in a subject include the administration of one or more agents. The agent can increase or induce hypothalamic expression of BDNF, can be a TrkB receptor agonist or a beta-3 adrenergic receptor agonist, or encode an agonist that modulates a hypothalamic-adipocyte axis. | 02-27-2014 |
Patent application number | Description | Published |
20100168215 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DISEASE - The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment thereof in the target cell(s) provides therapeutic benefit for subjects afflicted with a neurological disorder. | 07-01-2010 |
20100221200 | COMPOSITIONS AND METHODS FOR SKIN CARE - The present disclosure contemplates compositions and methods for skin care. In some embodiments, the compositions may comprise delta opioid receptor agonists. The skin care composition may comprise peptide delta opioid receptor agonists, non-peptide delta opioid receptor agonists, or combinations thereof. In further embodiments, the peptide delta opioid receptor agonists may be chosen from enkephalins and/or deltorphins. In yet other embodiments, the delta opioid receptor agonists may be conjugated to another molecule. For example, the delta opioid receptor agonist may be conjugated to a lipid in order to facilitate entry across the stratum corneum. Further disclosed herein is the cosmetic use of at least one combination as described above, in a composition suitable for topical application to the skin, as an agent for smoothing out wrinkles and fine lines, such as expression wrinkles. | 09-02-2010 |
20110274718 | System for Modulating Expression of Hypothalmic Brain-Derived Neurotrophic Factor (BDNF) - Methods for treating tumor associated diseases by administering a nucleic acid sequence encoding brain derived neurotrophic factor (BDNF) where the expression reduces the symptoms of the disease and compositions for mediation of enrichment-induced tumor resistance having brain derived neurotrophic factor (BDNF) are disclosed. | 11-10-2011 |
20110288160 | Treatment of Metabolic-Related Disorders Using Hypothalamic Gene Transfer of BDNF and Compositions Therefor - Described herein is a system which uses a gene therapy particle that includes at least one gene, cDNA, fragment or analogue of at least one neurotropin that binds to the trkB receptor or the trkB receptor itself. The gene therapy particle is capable of being delivered to a subject in need thereof for therapy of a metabolic disorder. In a particular aspect, this invention is directed to an inventive method that demonstrates a remarkable efficacy on lowering body weight. | 11-24-2011 |