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| 20080317761 | Peptide-Mediated Protein Transduction Into Cells of the Hematopoietic Lineage - A pharmaceutical composition comprises a therapeutic peptide or protein, a transport moiety capable of transporting said first peptide or protein into a hematopoietic cell differentiated from a common myeloid progenitor, and a linker between said first protein and said transport moiety, said linker susceptible to cleavage by an intracellular enzyme in the cell. A cell or collection of cells, e.g., platelets, containing such a composition is useful in methods for treating infection, inflammation, vascular injuries or any disorders involving or mediated by cells of the hematopoietic lineage. Methods of making such compostions are also disclosed. | 12-25-2008 |
| 20090130104 | FUSION PROTEINS FOR INHIBITION AND DISSOLUTION OF COAGULATION - Fusion proteins containing a ligand which specifically binds to a selected vascular bed linked to an anti-thrombotic molecule are provided. Also provided are methods for use of these fusion proteins to prevent coagulation, to dissolve blood clots and to protect against the risk of iatrogenic side effects including those arising from cancer therapy and specific vascular occluding agents. | 05-21-2009 |
| 20090264628 | CRYSTAL STRUCTURE OF HUMAN UROKINASE PLASMINOGEN ACTIVATOR AMINO TEMINAL FRAGMENT BOUND TO ITS RECEPTOR - Urokinase-type plasminogen activator (uPA) binds its cellular receptor (uPAR) with high affinity, thus localizing the generation of plasmin from plasminogen on the surface of a variety of cells. Disclosed herein is the structure of suPAR (uPAR | 10-22-2009 |
| 20100285015 | TARGETING RECOMBINANT THERAPEUTICS TO CIRCULATING RED BLOOD CELLS - Fusion proteins comprising a single chain antigen-binding domain (scFv) of a monoclonal antibody, linked to an anti-thrombotic agent, anti-inflammatory agent, or a pro-drug thereof are provided, where the polypeptide binds to a binding site (antigen) expressed on the surface of a red blood cell at a density greater than 5,000 copies per red blood cell. Pharmaceutical compositions comprising these fusion proteins, and methods of delivering an anti-thrombotic agent to the surface of a red blood cell via delivery of these fusion proteins, and methods of treating or preventing thrombosis, tissue ischemia, acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease via administration of the fusion proteins or compositions comprising same are also provided. | 11-11-2010 |
| 20110262466 | COMPOSITIONS CONTAINING THROMBOMODULIN DOMAINS AND USES THEREOF - Compositions are provided comprising a thrombomodulin domain linked to a targeting moiety that binds to a determinant on the surface of a target endothelial cell or red blood cell, wherein the thrombomodulin domain may be the extracellular domain, the N-terminal lectin-like domain, or an epidermal growth factor (EGF)-like domain. The targeting moiety may be a single chain antigen-binding domain (scFv), and the targeting moiety and thrombomodulin domain of the composition may be linked as a continuous polypeptide chain. Methods of delivery and use of a composition described herein are provided, as well as methods of treating or preventing thrombosis, inflammation, tissue ischemia, sepsis, acute lung injury (ALI), acute myocardial infarction (AMI), ischemic stroke, cerebrovascular disease, pulmonary embolism, or ischemic peripheral vascular disease is provided. | 10-27-2011 |
| 20130058929 | FUSION PROTEINS FOR INHIBITION AND DISSOLUTION OF COAGULATION OF THROMBI - Fusion proteins containing a ligand which specifically binds to a selected vascular bed linked to an anti-thrombotic molecule are provided. Also provided are methods for use of these fusion proteins to prevent coagulation, to dissolve blood clots and to protect against the risk of iatrogenic side effects including those arising from cancer therapy and specific vascular occluding agents. | 03-07-2013 |
| 20150037821 | METHODS OF IDENTIFYING HIT-ANTIBODIES AND PF4 ANTAGONISTS AND CELL LINES FOR USE THEREIN - Methods and cells or cell lines for identifying antibodies or fragments thereof that activate heparin-induced thrombocytopenia (HIT) are described. The methods comprise contacting a hematopoietic cell or cell line that comprises, in operative association, the platelet receptor FcyRIIA under the control of a suitable promoter, and a reporter construct comprising a reporter gene under the control of a promoter and transcription factor, which transcription factor is regulated downstream of the signaling cascade of activated FcyRIIA, with a test sample from a mammalian subject; a platelet factor 4 (PF4), a wild-type or variant of PF4 or a fragment thereof; and heparin; and detecting or measuring the level of reporter gene expression. | 02-05-2015 |
| 20150132778 | METHODS AND KITS FOR DIAGNOSING HEPARIN-INDUCED THROMBOCYTOPENIA - Provided herein are methods for diagnosing heparin-induced thrombocytopenia (HIT) in a subject. The methods comprise (a) contacting a PF4-heparin complex with a biological sample from the subject; (b) contacting the composition of part (a) with an HIT-like antibody; and (c) measuring the amount of bound HIT-like antibody. In one embodiment, a significant decrease in the amount of bound HIT-like antibody in the composition of part (b) as compared to a control level is indicative of a diagnosis of HIT in the subject. Also provided are assay kits for performing the methods of the invention. | 05-14-2015 |
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| 20110110193 | WIRELESS EXPLORATION SEISMIC SYSTEM - Systems and methods for seismic data acquisition employing a dynamic multiplexing technique. The dynamic multiplexing technique may include advancing one or more modules in a seismic array through a multiplexing signature sequence in successive transmission periods. The multiplexing signature sequence may be random or pseudo-random. A shared multiplexing signature sequence may be used at all the modules in the seismic array. As such, modules belonging to a common collision domain may operate out of phase with respect to the shared multiplexing signature sequence. | 05-12-2011 |
| 20120008460 | DATA ACQUISITION SYSTEM WITH REMOVABLE - Data acquisition modules and systems including batteries with integrated data storage. The battery with integrated data storage can be selectively removed from the data acquisition module. This allows for reduced logistical effort associated with data retrieval and battery charging. For instance, the entire data acquisition module need not be transported to a central location for data recovery and charging, but rather the removable battery with integrated storage may be removed and transported. Also facilitated is extended surveys in that the battery or storage module may be replaced, such that survey design limitations such as storage capacity or battery life may be eliminated. | 01-12-2012 |
| 20120170407 | SYSTEMS AND METHODS FOR IMPROVING BANDWIDTH OF WIRELESS NETWORKS - Systems and methods for seismic data acquisition with location aware network nodes. Based on location information of the nodes of the network, a multiplexing signature may be provided for the node. The location information may be used in conjunction with other information (e.g., location information of other nodes in the network and transmission ranges for nodes in the network) to determine collision domains. A multiplexing signature may be assigned to a node based on information regarding a collision domain to which the node belongs. As such, the assigned multiplexing signature may be used to avoid data collisions. | 07-05-2012 |
| 20120170408 | SYSTEMS AND METHODS FOR SEISMIC DATA ACQUISITION - Systems and methods for seismic data acquisition utilizing wireless modules to perform real time data read out. The wireless modules may be assigned a shared multiplexing sequence through which each module advances in successive transmission periods. Wireless modules belonging to a shared collision domain may be operated out of phase from one another with respect to the shared multiplexing signature sequence. As such, a dynamic multiplexing regime may be implemented. The shared multiplexing signature sequence may include, among others, a plurality of different frequencies, a plurality of different codes, or a plurality of different discrete time periods. | 07-05-2012 |
| 20130135969 | Systems and Methods for Seismic Data Acquisition - Systems and methods for seismic data acquisition utilizing wireless modules to perform real time data read out. The wireless modules may be assigned a shared multiplexing sequence through which each module advances in successive transmission periods. Wireless modules belonging to a shared collision domain may be operated out of phase from one another with respect to the shared multiplexing signature sequence. As such, a dynamic multiplexing regime may be implemented. The shared multiplexing signature sequence may include, among others, a plurality of different frequencies, a plurality of different codes, or a plurality of different discrete time periods. | 05-30-2013 |
| 20130148469 | WIRELESS EXPLORATION SEISMIC SYSTEM - Systems and methods for seismic data acquisition employing a dynamic multiplexing technique. The dynamic multiplexing technique may include advancing one or more modules in a seismic array through a multiplexing signature sequence in successive transmission periods. The multiplexing signature sequence may be random or pseudo-random. A shared multiplexing signature sequence may be used at all the modules in the seismic array. As such, modules belonging to a common collision domain may operate out of phase with respect to the shared multiplexing signature sequence. | 06-13-2013 |
| 20130176817 | DATA ACQUISITION SYSTEM WITH REMOVABLE BATTERY HAVING INTEGRATED DATA STORAGE - Data acquisition modules and systems including batteries with integrated data storage. The battery with integrated data storage can be selectively removed from the data acquisition module. This allows for reduced logistical effort associated with data retrieval and battery charging. For instance, the entire data acquisition module need not be transported to a central location for data recovery and charging, but rather the removable battery with integrated storage may be removed and transported. Also facilitated is extended surveys in that the battery or storage module may be replaced, such that survey design limitations such as storage capacity or battery life may be eliminated. | 07-11-2013 |
| 20140204704 | SYSTEMS AND METHODS FOR IMPROVING BANDWIDTH OF WIRELESS NETWORKS - Systems and methods for seismic data acquisition with location aware network nodes. Based on location information of the nodes of the network, a multiplexing signature may be provided for the node. The location information may be used in conjunction with other information (e.g., location information of other nodes in the network and transmission ranges for nodes in the network) to determine collision domains. A multiplexing signature may be assigned to a node based on information regarding a collision domain to which the node belongs. As such, the assigned multiplexing signature may be used to avoid data collisions. | 07-24-2014 |
| 20140307523 | BURIED ARRAY WIRELESS EXPLORATION SEISMIC SYSTEM - Systems and methods are provided for acquiring data using a wireless network and a number of nodes that may be configured to collect acquired data and forward data to a central recording and control system. The acquired data may include seismic and/or auxiliary data. A node for use in data acquisition may include an acquisition module in operative communication with a buried sensor array operable to output acquired data. The processor may also be operable to receive acquired data from another data acquisition module in the wireless network. | 10-16-2014 |
| 20140307524 | MULTIMODE SEISMIC UNIT AND ASSOCIATED METHODOLOGY - A multimode seismic unit can selectively operate in any one or more of multimode readout modes. In one embodiment, a multimode seismic unit ( | 10-16-2014 |
| 20140307526 | MULTIMODE SEISMIC SURVEY SYSTEM - A multimode seismic survey system is disclosed where seismic information for a given seismic survey is read out by different seismic units using different modes. Such multimode systems encompass hybrid arrays where information is read out via different output modes for a single seismic event, and other multimode arrays where seismic information is read out via different modes for different seismic events. The modes utilized in such arrays may include wireless, nodal and/or cable modes. The multimode arrays can be implemented using multimode seismic units or single mode seismic units. In any event, the multimode arrays can be utilized to achieve a combination of advantages associated with the different readout modes or to address any of various multimode mode contexts in relation to seismic surveys. | 10-16-2014 |
| 20150124563 | WIRELESS EXPLORATION SEISMIC SYSTEM - Systems and methods for seismic data acquisition employing a dynamic multiplexing technique. The dynamic multiplexing technique may include advancing one or more modules in a seismic array through a multiplexing signature sequence in successive transmission periods. The multiplexing signature sequence may be random or pseudo-random. A shared multiplexing signature sequence may be used at all the modules in the seismic array. As such, modules belonging to a common collision domain may operate out of phase with respect to the shared multiplexing signature sequence. | 05-07-2015 |
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| 20080208295 | Phototherapy Treatment and Device to Improve the Appearance of Nails and skin - A method and apparatus for using phototherapy to beneficially improve the appearance of nails and skin. Light can be applied to nails and skin that is primarily germicidal to inactivate organisms that cause infections; applied as primarily cleansing light in which case it primarily improves the appearance of the nails and skin; or applied as a combination of the two, namely germicidal and cleansing light, in which case it is termed cleansing light. By applying the light for a set time and intensity to nails can be improved in appearance, whether or not an infection is present. By applying the light to skin with or without the presence of other compounds, skin appearance can be approved. | 08-28-2008 |
| 20090143842 | Phototherapy Treatment and Device for Infections, Diseases, and Disorders - A device to treat infections, diseases, and disorders. The device can be used to treat part of a larger organism such as using the device to kill cancerous cells in humans or animals or to kill parasites. The invention can also may be used to treat fungal and bacterial nail infections of the hands and feet which are difficult to treat with oral and topical drugs. | 06-04-2009 |
| 20090211585 | Coverings for Phototherapy and Topical Treatment - A method to effectively cover parts of the body that should not receive phototherapy treatment. The invention can also be used to cover parts of the body that are not receiving topical treatments and are adjacent to such areas being treated. Three variations of the covering device can be used separately or together in various combinations. An extremity covering device covers a large portion of a hand, foot or other extremity. A digit covering device covers one finger or toe. A skin covering device is used to cover areas not covered by the extremity or digit covering devices, or can be used separately to cover a finite area of the skin, nails, or other portion of a patient. | 08-27-2009 |
| 20110178510 | Method and Device to Inactivate and Kill Cells and Organisms that are Undesirable - A method, means, and apparatus to prevent and treat infections and disorders using germicidal light to inactivate and/or kill the organisms or cells that cause infections and other disorders. The method of treatment comprises irradiating the area to be treated using electromagnetic radiation of a germicidal nature. The method utilizes a previously unrecognized ability of germicidal light to penetrate the skin, nails, and other membranes sufficiently to successfully treat and prevent disorders. The electromagnetic radiation damages the organisms and cells that cause disorders such as skin and nail infections and renders them substantially incapable of reproducing. Without the ability to replicate the organism cannot continue to infest the skin and nails. The damage inflicted can also be sufficient to kill the organism outright. An infection is thereby prevented (if organisms are present, but infection has not yet begun), and the infection is cured if the infection already exists. | 07-21-2011 |
