Patent application number | Description | Published |
20110264188 | RE-ESTABLISHMENT OF BLOOD FLOW IN BLOCKED HUMAN ARTERIES BY TRANSFERRING NANO-ENCAPSULATED DRUG THROUGH MEDICAL DEVICES, DESIGNED FOR THE SAME AND RELEASING THE NANO-ENCAPSULATED DRUG IN HUMAN ARTERY WITH BODY PH - A drug-delivering insertable medical device for treating a medical condition associated with a body lumen is disclosed. The drug-delivering insertable medical device includes an outer surface coated with two or more nano-carriers having two or more average diameters. A nano-carrier of the two or more nano-carriers has an average diameter suitable for penetrating one or more layers of two or more layers of the body lumen. The nano-carrier includes a drug surrounded by an encapsulating medium. The encapsulating medium includes one or more of a biological agent, a blood excipient, and a phospholipid. | 10-27-2011 |
20120276280 | METHOD AND SYSTEM FOR COATING INSERTABLE MEDICAL DEVICES - A coating system for coating an Insertable Medical Device (IMD) with one or more drugs is disclosed. The coating system includes a spray nozzle unit for coating the IMD with one or more drugs. The IMD includes a guiding member, a coating member and a supporting member. The IMD is passed through a protection tube such that the guiding member is located within the protection tube and an end of the supporting member is connected to a holder to expose the coating member of the IMD to the spray nozzle unit. The protection tube is received by a mandrel fixture which includes a circular disc for holding and rotating the protection tube and the IMD within the protection tube. When the protection tube along with the IMD is rotated, the spray nozzle unit coats the coating member of the IMD with the one or more drugs. | 11-01-2012 |
20120277726 | DRUG-ELUTING INSERTABLE MEDICAL DEVICE FOR TREATING ACUTE MYOCARDIAL INFARCTION, THROMBUS CONTAINING LESIONS AND SAPHENOUS-VEIN GRAFT LESIONS - A method for delivering at least one drug at a target site in a blood vessel for treating at least one of an acute myocardial infarction, a thrombus containing lesion and a saphenous-vein graft lesion is disclosed. The method includes delivering nano-carriers at the target site. The nano-carriers include one or more drugs encapsulated with a first biological agent. The nano-carriers further include a second biological agent in contact with one or more of the first biological agent and the one or more drugs. The first biological agent and the second biological agent have a first dissolution rate and a second dissolution rate respectively. The first dissolution rate is different from the second dissolution rate. The one or more drugs are released at the target site from the nano-carriers at a first release rate and a second release rate in response to dissolution of the first biological agent and the second biological agent, respectively. | 11-01-2012 |
20120277727 | METHOD AND AN INSERTABLE MEDICAL DEVICE FOR DELIVERING ONE OR MORE PRO-HEALING AGENTS TO A TARGET SITE WITHIN A BLOOD VESSEL POST-DEPLOYMENT OF A STENT - The invention discloses an insertable medical device for delivering one or more pro-healing agents to a site of deployment of a stent in a blood vessel. The surface of the insertable medical device is coated with nano-carriers that include the one or more pro-healing agents encapsulated with one or more biological agents. The nano-carriers are released when the insertable medical device is expanded at the site. The nano-carriers thus released penetrate tissues at the site resulting in dissolution of the one or more biological agents. Thereafter, the one or more pro-healing agents are released from the nano-carriers at the site. Thus, an in-tissue release of the one or more pro-healing agents at the site is achieved thereby improving endothealisation, extracellular matrix formation and healing at the site post deployment of the stent in the blood vessel. | 11-01-2012 |
20120283635 | METHOD AND A BALLOON CATHETER ASSEMBLY FOR TREATING BIFURCATION LESIONS - The invention discloses a balloon catheter assembly for delivering nano-carriers to bifurcation lesions in one or more of a main branch and a side branch of a blood vessel bifurcation within 30 to 90 seconds. The balloon catheter assembly includes two or more balloons designed for use in the blood vessel bifurcation. A surface of one or more of the two or more balloons is coated with the nano-carriers. The nano-carriers include one or more drugs encapsulated with one or more biological agents. | 11-08-2012 |
20120315300 | INSERTABLE MEDICAL DEVICES WITH A POROUS BED FOR DELIVERING NANO-CARRIERS TO A TARGET SITE AND METHODS OF PREPARING THE SAME - The invention discloses a method of coating a medical device. The method includes applying a coating composition on the medical device to form a layer on the medical device. The coating composition includes one or more of one or more biological agents and heparin dissolved in a mixture of a first solvent and a second solvent. The first solvent and the second solvent have different evaporation temperatures. Subsequently, at least a part of one of the first solvent and the second solvent present in the coating composition is evaporated to create a plurality of pores in the layer. Thereafter, one or more drugs are deposited in the plurality of pores. When the medical device is positioned and expanded at a target site, the one or more drugs are released from the plurality of pores. | 12-13-2012 |
20120321670 | FORMULATIONS OF NANO-CARRIERS AND METHODS OF PREPARING THE SAME - A method of preparing nano-carriers is disclosed. The method includes mixing an organic solution of a drug and an organic solution of a biological agent separately with a predetermined amount of water having one or more dissolved surfactants to obtain a first mixture and a second mixture respectively. Subsequently, the first mixture and the second mixture are homogenized separately to obtain a solution of nano-crystals of the drug and a solution of nano-particles of the biological agent respectively. Thereafter, the solution of nano-crystals of the drug and the solution of nano-particles of the biological agent are together subjected to an ultra-sound homogenization to obtain a solution of nano-carriers. An interfacial extraction and/or a dialysis are then performed on the solution of nano-carriers to obtain the nano-carriers. Formulations of the nano-carriers are also disclosed. | 12-20-2012 |
20140142503 | METHOD AND A BALLOON CATHETER ASSEMBLY FOR TREATING BIFURCATION LESIONS - A balloon catheter assembly for delivering nano-carriers to bifurcation lesions in one or more of a main branch and a side branch of a blood vessel bifurcation within 30 to 90 seconds is provided. The balloon catheter assembly includes two or more balloons designed for use in the blood vessel bifurcation. The balloon catheter assembly may also include one or more stents. A surface of one or more of the two or more balloons is coated with the nano-carriers. Stents, when included, may also be coated with the nano-carriers. The nano-carriers include one or more drugs encapsulated with one or more biological agents. | 05-22-2014 |