Dimitrova
Mariana Dimitrova, Medford, MA US
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20150239970 | Stable, Low Viscosity Antibody Formulation - The present invention relates to a stable, low viscosity antibody formulation, wherein the formulation comprises a high concentration of anti-IL6 antibody. In some embodiments, the invention is directed to a stable, low viscosity antibody formulation comprising about 50 mg/mL to about 400 mg/mL of an anti-IL6 antibody, and arginine, wherein the antibody formulation is in an aqueous solution and has a viscosity of less than 20 cP at 23° C. Also provided are methods of making and methods of using such antibody formulations. | 08-27-2015 |
Mariana N. Dimitrova, Frederick, MD US
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20120009199 | ANTIBODY FORMULATIONS - The present invention relates to formulations comprising sucrose, and methods of making such formulations, wherein the sucrose content promotes the reduction or elimination of the reversible self-association (RSA) tendency of the antibody in the formulation. The present invention also relates to formulations comprising an anti-PDGFR-alpha antibody or antibody fragment. Such antibodies can be used in various methods of treatment. The application further relates to a method of eliminating or reducing the RSA tendency of antibodies in a formulation. | 01-12-2012 |
Milena Dimitrova, Muenchen DE
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20080239788 | INTEGRATED CIRCUIT HAVING A RESISTIVELY SWITCHING MEMORY AND METHOD - An integrated circuit having a resistance-based or resistively switching memory cell, and a method for operating a resistively switching memory cell is disclosed. One embodiment is adapted to be put in a low-resistance state by applying a first threshold voltage and in a high-resistance state by applying a second threshold voltage, wherein reading out of the data content from the memory cell is performed by applying a voltage to the memory cell in the range of the first or second threshold voltage or a higher voltage. | 10-02-2008 |
Neenka Dimitrova, Pelham Manor, NY US
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20110093448 | SYSTEM METHOD AND COMPUTER PROGRAM PRODUCT FOR PEDIGREE ANALYSIS - This invention pertains in general to the field of data mining. More particularly the invention relates to a system ( | 04-21-2011 |
Nevenka Dimitrova, Pelham, NY US
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20110224103 | METHOD FOR DESIGN OF AN OLIGINUCLEOTIDE ARRAY - A method is provided allowing for automatic selection of enzymes to be used in protocols such as methylation profiling, chip-on-chip, and comparative genomic hybridization experiments. The method may also maximize the space on a micro array for a given experiment. This means that the results from the micro array are improved. The method also improves zero-in and focus of significant patterns on a micro array. This enhances the ability to distinguish two separate classes of samples, e.g. tumour vs. normal, aggressive vs. non-aggressive, male vs. female, etc. Furthermore, a computer readable medium and a device are also provided. | 09-15-2011 |
Nevenka Dimitrova, Eindhoven NL
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20110246082 | METHOD FOR SPECTRAL DNA ANALYSIS - The present invention relates a method for analyzing a DNA sequence. The DNA sequence by converting the DNA sequence into a plurality of binary indicator sequences (BIS), and applying short term Fourier transform (STFT) on the binary indicator sequences. A binning function (BF) is applied to the Fourier coefficients (Usk_X(k)) and thereby modifying the corresponding Fourier coefficients (Usk_X(k)). Finally, substantially equal modified Fourier coefficients (Usk_X(k)) is found. The invention provides the user with a much improved ability to see unique strong patterns in vast amount of DNA sequence data. | 10-06-2011 |
20140148344 | ASSOCIATION MARKERS FOR BETA THALASSEMIA TRAIT - The present invention relates to isolated nucleic acid molecules of SEQ ID NO: 1 to SEQ ID NO: 14 which show a single polymorphic change at position 501, where the wildtype nucleotide is replaced by an indicator nucleotide, respectively. The present invention further relates to the mentioned nucleic acid molecules wherein a panel of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 of the polymorphic, changed sequences comprising the mentioned indicator nucleotides constitutes a marker for beta thalassemia, in particular of beta thalassemia minor. Further envisaged are specific panels comprising SEQ ID NO: 1; or SEQ ID NO 1 and 2; or SEQ ID NO: 1, 2 and 3, or SEQ ID NO: 1, 2, 3 and 4; or SEQ ID NO: 1 to 5; or SEQ ID NO: 1 to 6; or SEQ ID NO: 1 to 7; or SEQ ID NO: 1 to 14; or SEQ ID NO: 8 and 14; or SEQ ID NO: 8 and 9; or SEQ ID NO: 2, 4 and 13. The present invention further relates to a method of detecting or diagnosing beta thalassemia, preferably of beta thalassemia minor, in a subject, comprising the steps of: (a) isolating a nucleic acid from a subject's sample, (b) determining the nucleotide sequence and/or molecular structure present at one or more of the mentioned polymorphic sites, wherein the presence of an indicator nucleotide indicative of the presence of beta thalassemia. Also envisaged are a corresponding composition for detecting or diagnosing beta thalassemia, the use of the mentioned nucleic acid molecules for detecting or diagnosing beta thalassemia or for screening a population for the presence of beta thalassemia, as well as a corresponding kit. The methods, compositions, uses and kits of the invention also relate to the assessment of the risk of developing beta thalassemia in a subject and/or in a subject's progeny. | 05-29-2014 |
Nevenka Dimitrova, Bangalore IN
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20090041356 | Method and Device for Automatic Generation of Summary of a Plurality of Images - Method and device for providing a summary of a plurality of images, e.g. a video sequence. The method includes dividing the video sequence into a plurality of segments. The segments are analyzed with respect to content and a set of content descriptors are associated to the segments. Preferably, additional textual information about the segments, screenplay etc., is used to determine the content descriptors. A graph representing relations between the segments is constructed indicating relations between segments. Weights are associated to the relations so as to represent a measure of relation, e.g. a logical correlation, between segments. The weights are based on the calculated content descriptors. A relevance measure for a segment is determined based on all weights associated with relations to said segment. Finally, a summary is generated by selecting the most relevant segments. The method can create an automatic summary of a film that preserves all the logical plot of the original but is shorter in duration (e.g. | 02-12-2009 |
20090055746 | MULTIMEDIA PRESENTATION CREATION - The present invention enables combining personal media content and additional content with the purpose of generating a more appealing and engaging experience to the user when being presented the personal media content. The invention therefore relates to a method and a device for generating a multimedia presentation, comprising obtaining a user selection of a first media file (step | 02-26-2009 |
Nevenka Dimitrova, Bangalore, NY US
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20080221942 | Automatic Generation of Trailers Containing Product Placements - This invention relates to a method and computer system for automatic generation of trailers. More specifically it relates to a method for generating revenues from providers of content data. The method generally comprises the steps of finding product placement data in a super set of data. When these product placements have been found they are preferably matched with a user profile and segments, of the superset comprising these product placements with a positive match, are selected and merged into a subset of data. A counter may keep track of which product placement that has been chosen and how many times a product placement has been chosen and viewed. Based on the value of the counter an invoice is created. | 09-11-2008 |
Nevenka Dimitrova, Pelman Manor, NY US
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20130308872 | METHOD, APPARATUS, AND COMPUTER PROGRAM PRODUCT FOR COMPRESSION AND DECOMPRESSION OF AN IMAGE DATASET - A method for compression and/or decompression of bio-medical images such as DNA sequencing images is provided. The method comprises regeneration of a complete image using multiple distribution functions generated on the fly. The compression ratio achieved is in the order of 10 to 20 times, and is near lossless with respect to the clinically relevant information; which makes it well suited for these DNA sequencing images. | 11-21-2013 |
Nevenka Dimitrova, Briarcliff Manor, NY US
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20110069898 | METHOD, APPARATUS, AND COMPUTER PROGRAM PRODUCT FOR COMPRESSION AND DECOMPRESSION OF AN IMAGE DATASET - A method for compression and/or decompression of bio-medical images such as DNA sequencing images is provided. The method comprises regeneration of a complete image using multiple distribution functions generated on the fly. The compression ratio achieved is in the order of 10 to 20 times, and is near lossless with respect to the clinically relevant information; which makes it well suited for these DNA sequencing images. | 03-24-2011 |
20110189098 | THERAPY DELIVERY AND MONITORING USING A GENE OF INTEREST-REPORTER FUSION PROTEIN AND OPTICAL IMAGING - The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene fluorescence of interest induced by said compound at the same time. | 08-04-2011 |
20110281756 | COMPOSITIONS AND METHODS FOR MICRO-RNA EXPRESSION PROFILING OF COLORECTAL CANCER - The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer. | 11-17-2011 |
Pepa Dimitrova, Kaiserslautern DE
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20120289724 | Process For Purifying Crude Fatty Alcohols - Described is a process for simultaneously purifying fatty alcohols and obtaining a fraction of free fatty acids, wherein: | 11-15-2012 |
Pepa Dimitrova, Worms DE
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20130281696 | PROCESS FOR PREPARING BRANCHED ALCOHOLS - Process for preparing branched alcohols of the general formula (I) | 10-24-2013 |
20130324770 | METHOD FOR WORKING UP MIXTURES - Method for working up a mixture comprising at least one alcohol of the general formula (I) | 12-05-2013 |
Tatiana Dimitrova, Braine-L'Alleup BE
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20140294746 | Aminofunctional Silicone Emulsions - Aqueous silicone emulsions are disclosed comprising: A) an aminofunctional organopolysiloxane, B) a quaternary ammonium surfactant having a formula R | 10-02-2014 |
Tatiana Dimitrova, Braine L'Alleud BE
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20110293677 | Fabric And Fibre Conditioning Additives - A fabric, fibre, hair or skin conditioning additive for use in a liquid cleaning product is encapsulated within a shell comprising a silicon-containing polymer network. | 12-01-2011 |
20110300085 | Home And Personal Care Compositions - The present invention relates to home and personal care compositions comprising a silicone oil-in-water emulsion stabilized by a protein or peptide and at least one home and/or personal care ingredient. Such compositions tend to provide desirable characteristics for the care and conditioning of hair, skin and fabric. | 12-08-2011 |
20110300094 | Silicone Oil-In-Water Emulsions - A silicone oil-in-water emulsion comprising 3 to 90% by volume of a silicone oil phase, characterized in that the emulsion is stabilized by a protein and/or peptide present at 0.25 to 20% by weight of the emulsion. The emulsion contains less than 25% by weight and preferably zero % by weight of non-polymeric amphiphilic surfactant based on the weight of protein or peptide. A process for preparing the emulsion is also described. | 12-08-2011 |
20110311723 | Silicate Shell Microcapsules For Treating Textiles - Compositions containing suspended silicate shell microcapsules of a silicone textile treatment are disclosed. These compositions are particularly useful as textile treatments to impart hydrophobicity, softness, and flame retardant properties. | 12-22-2011 |
20110313060 | Silicone Dispersions - A non-aqueous silicone emulsion is provided. It comprises a continuous phase of a polar organic liquid containing droplets of an organopolysiloxane dispersed therein. An organic wax, which has a melting point in the range 40 to 100° C. and is sparingly soluble in the polar organic liquid at 25° C., is dispersed in the polar organic liquid continuous phase as a network of interconnected particles which stabilises the organopolysiloxane droplets in emulsion in the polar organic liquid. A process for the production of the emulsion is also disclosed. | 12-22-2011 |
20140234247 | Aminofunctional Organosiloxanes - Aminofunctional silicone compositions are disclosed comprising: an organopolysiloxane having an average formula of (CH | 08-21-2014 |
20140308229 | Aminofunctional Silicone Emulsions For Fiber Treatments - Methods for treating fibers are disclosed with aqueous silicone emulsions comprising: A) an aminofunctional organopolysiloxane, B) a quaternary ammonium surfactant having a formula R | 10-16-2014 |
20150087747 | Water Repellent Organopolysiloxane Materials - A process for increasing the hydrophobicity of a porous product by treating the product or a composition providing the product, with a water repellent material, characterised in that the porous product or a composition providing the product is treated with an aqueous suspension of microcapsules, where the microcapsules comprise a water repellent organopolysiloxane core material and a shell of a silicon-based network polymer comprising silica units. | 03-26-2015 |
20150174017 | PROCESS FOR PREPARING SILICATE SHELL MICROCAPSULES - A process for preparing silicate shell microcapsules comprises adding a water reactive silicon compound to an oil in water emulsion, thereby condensing and polymerizing the water reactive silicon compound to form silicate shell microcapsules having a core comprising the oil phase of the said emulsion. The water reactive silicon compound comprises a tetraalkoxysilane and an alkoxysilane having an amino or quaternary ammonium substituted alkyl group. | 06-25-2015 |
20150174018 | FABRIC AND FIBRE CONDITIONING ADDITIVES - A fabric, fibre, hair or skin conditioning additive for use in a liquid cleaning product is encapsulated within a shell comprising a silicon-containing polymer network. | 06-25-2015 |
Tatiana Dimitrova, Braine-L' Alleud BE
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20120021023 | Process For Preparing Silicate Shell Microcapsules - A process for preparing silicate shell microcapsules comprises adding a water reactive silicon compound to an oil in water emulsion, thereby condensing and polymerizing the water reactive silicon compound to form silicate shell microcapsules having a core comprising the oil phase of the said emulsion. The water reactive silicon compound comprises a tetraalkoxysilane and an alkoxysilane having an amino or quaternary ammonium substituted alkyl group. | 01-26-2012 |
Vania Slavchova Dimitrova, Sofia BG
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20120143928 | FILE SYSTEM TRANSACTION LOG FLUSH OPTIMIZATION - Various embodiments of systems and methods for file system transaction log flush optimization are described herein. An optimizer is working as an intelligent processing unit, autonomously determining the best possible time to flush all collected transaction data modifications to the file system when operating under high load, or flushing each modification separately under low load. When operating under high load, batches of data modifications are collected and written together to the file system in a single write operation, thus decreasing the number of write operations and achieving better utilization of the system resources. | 06-07-2012 |