Desjarlais
Frank J. Desjarlais, Canton, MI US
Patent application number | Description | Published |
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20120197508 | VEHICLE HAVING KEY-BASED PERFORMANCE MODE - A system or method for controlling a vehicle having a normal operating mode and a performance operating mode include detecting a removable key unique to each vehicle associated with the performance operating mode, operating the vehicle in the performance operating mode in response to detecting the removable key, and operating the vehicle in the normal operating mode otherwise. Operation in performance or track mode may include adjusting valve timing using a variable cam timing device, adjusting idle speed control, adjusting torque response, and/or enhancing engine braking Performance mode operation may also disable one or more features, such as a transmission skip shift feature. | 08-02-2012 |
20130036529 | GLOVE HAVING CONDUCTIVE INK AND METHOD OF INTERACTING WITH PROXIMITY SENSOR - A glove is provided that includes a body configured to engage a hand and a plurality of finger sheaths configured to cover fingers of the hand. The glove also has an electrically conductive ink disposed at least at the tip of at least one of the finger sheaths to interact with a proximity sensor, such as a capacitive sensor. | 02-14-2013 |
20150283975 | METHOD AND SYSTEM FOR SELECTING VEHICLE PERFORMANCE - Methods and systems for selecting vehicle operating modes in response to output of remote security token devices are described. In one example, a vehicle operating mode may be determined when two key fobs having different, but valid, security token assignments are present within a vehicle cabin. Further, one mode of a two mode key fob may be selectively deactivated and reactivated to provide system flexibility. | 10-08-2015 |
John Desjarlais, Pasadena, CA US
Patent application number | Description | Published |
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20110189178 | Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions - The present application relates to therapeutic moieties displaying reduced immunogen response, particularly for therapeutic purposes. | 08-04-2011 |
20130156754 | Optimized Fc Variants and Methods For Their Generation - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 06-20-2013 |
20130156758 | Optimized Fc Variants and Methods for Their Generation - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 06-20-2013 |
20130171095 | Method for Purifying Antibodies - The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains. | 07-04-2013 |
20130177553 | Novel Compositions and Methods for Treating IgE-Mediated Disorders - The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. | 07-11-2013 |
20130209457 | Optimized Fc Variants - The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region. | 08-15-2013 |
20130243762 | Optimized Fc Variants and Methods for Their Generation - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 09-19-2013 |
20130261289 | Optimized Fc Variants - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 10-03-2013 |
20130273043 | Optimized Fc Variants - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 10-17-2013 |
20130302315 | Optimized Fc Variants - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 11-14-2013 |
20140073768 | OPTIMIZED Fc VARIANTS - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 03-13-2014 |
20140161790 | ENGINEERED IMMUNOGLOBULINS WITH EXTENDED IN VIVO HALF-LIFE - The present application relates to immunoglobulin compositions with improved half-life, and their application, particularly for therapeutic purposes. | 06-12-2014 |
20140212435 | RAPID CLEARANCE OF ANTIGEN COMPLEXES USING NOVEL ANTIBODIES - The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. | 07-31-2014 |
20140212436 | RAPID CLEARANCE OF ANTIGEN COMPLEXES USING NOVEL ANTIBODIES - The present invention relates to rapid clearance molecules that bind target antigens and FcγRIIb with increased affinity as compared to parent molecules, said compositions being capable of causing accelerated clearance of such antigens. Such compositions are useful for treating a variety of disorders, including allergic diseases, atherosclerosis, and a variety of other conditions. | 07-31-2014 |
20140288275 | NOVEL HETERODIMERIC PROTEINS - The invention provides novel heterodimeric proteins including heterodimeric antibodies. | 09-25-2014 |
20140294759 | TARGETING REGULATORY T CELLS WITH HETERODIMERIC PROTEINS - The present invention relates to methods and compositions for modulating T cells. The modulation includes suppressing or inducing regulatory T cells or cytotoxic T cells. | 10-02-2014 |
20140294823 | HETERODIMERIC PROTEINS - The present invention describes novel immunoglobulin compositions that co-engage at least two antigens, e.g. a first and second antigen, or, as outlined herein, three or four antigens can be bound, in some of the scaffold formats described herein. First and second antigens of the invention are herein referred to as antigen-1 and antigen-2 respectively (or antigen-3 and antigen-4, if applicable. As outlined herein, a number of different formats can be used, with some scaffolds relying combinations of monovalent and bivalent bindings. | 10-02-2014 |
20140294835 | NOVEL HETERODIMERIC PROTEINS - The invention provides heterodimeric antibodies comprising a first heavy chain comprising a first Fc domain and a single chain Fv region that binds a first antigen. The heterodimeric antibodies also comprise a second heavy chain comprising a second Fc domain, a first variable heavy chain and a first variable light chain, wherein the first and second Fc domains are different. | 10-02-2014 |
20140322217 | NOVEL HETERODIMERIC PROTEINS - The invention provides heterodimeric antibodies comprising a first heavy chain comprising a first Fc domain and a single chain Fv region that binds a first antigen. The heterodimeric antibodies also comprise a second heavy chain comprising a second Fc domain, a first variable heavy chain and a first variable light chain, wherein the first and second Fc domains are different. | 10-30-2014 |
20140356381 | METHODS OF PURIFYING HETERODIMERIC PROTEINS USING IMMUNOGLOBULIN CLASS SWITCHING - The present invention describes novel immunoglobulin compositions that co-engage at least two antigens, e.g. a first and second antigen, or, as outlined herein, three or four antigens can be bound, in some of the scaffold formats described herein. First and second antigens of the invention are herein referred to as antigen-1 and antigen-2 respectively (or antigen-3 and antigen-4, if applicable. As outlined herein, a number of different formats can be used, with some scaffolds relying combinations of monovalent and bivalent bindings. | 12-04-2014 |
20140363426 | HETERODIMERIC PROTEINS - In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain. | 12-11-2014 |
20140370021 | OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 12-18-2014 |
20140377270 | OPTIMIZED ANTIBODY VARIABLE REGIONS - The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. | 12-25-2014 |
20150030592 | OPTIMIZED Fc VARIANTS - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 01-29-2015 |
20150031862 | OPTIMIZED Fc VARIANTS - The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 01-29-2015 |
20150071948 | NOVEL IMMUNOGLOBULIN VARIANTS - The present invention relates to Fc variants with optimized Fc ligand binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc ligand binding properties, and methods for using same. | 03-12-2015 |
20150079082 | OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 03-19-2015 |
20150093379 | NOVEL COMPOSITIONS AND METHODS FOR TREATING IgE-MEDIATED DISORDERS - The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. | 04-02-2015 |
20150139985 | NOVEL COMPOSITIONS AND METHODS FOR TREATING IgE-MEDIATED DISORDERS - The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. | 05-21-2015 |
20150152183 | Fc VARIANTS WITH ALTERED BINDING TO FcRn - The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes. | 06-04-2015 |
20150232567 | Fc Variants with Increased Affinity for FcyRIIc - The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 08-20-2015 |
20150307629 | Bispecific antibodies that bind to CD38 and CD3 - The invention provides novel heterodimeric proteins including heterodimeric antibodies. | 10-29-2015 |
20150315284 | OPTIMIZED Fc VARIANTS - The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region. | 11-05-2015 |
John J. Desjarlais, Pasadena, CA US
Patent application number | Description | Published |
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20090053211 | Optimized Fc variants - The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 02-26-2009 |
John Desjarlais, Monrovia, CA US
Patent application number | Description | Published |
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20150239966 | COMPLEMENT COMPONENT C5 ANTIBODIES - The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement C5. Specifically, the disclosure is related to C5 antibodies. | 08-27-2015 |
John Rudolph Desjarlais, Pasadena, CA US
Patent application number | Description | Published |
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20090041770 | Fc VARIANTS WITH ALTERED BINDING TO FcRn - The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes. | 02-12-2009 |
20090068177 | Optimized Fc variants and methods for their generation - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 03-12-2009 |
20090081208 | Optimized Fc variants and methods for their generation - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 03-26-2009 |
20090092599 | Optimized Fc variants and methods for their generation - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 04-09-2009 |
20120230980 | OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION - The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | 09-13-2012 |
Matthew G. Desjarlais, Winnipeg CA
Patent application number | Description | Published |
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20090058068 | METHOD FOR BINDING A BOOK WITH A HELICAL PLASTIC COIL - A helical plastic coil is used for binding a collated book having a stack of pages with aligned holes along one edge of the book where a leading end of the filament is fed into a first hole at a first end of the book and the coil is rotated about its axis such that the leading end is threaded through the holes by entering each of the holes until the coil is threaded through all of the holes. The leading end of the coil is sheared by an anvil and blade so as to define a leading apex and a leading surface inclined rearwardly from the leading apex along the filament and across the filament. The leading apex is arranged such that, as the leading end enters each of the holes in turn, the leading apex is located on the leading end of the filament at a position thereon facing away from the trailing end of the coil and spaced from the end of the hole facing the first end of the book. | 03-05-2009 |
20100150682 | FORMING, INSERTION AND END CRIMPING OF HELICAL COILS FOR BOOKBINDING - Apparatus for binding a book with a helical plastic coil includes a forming mandrel for forming helical coils from a heated elongate plastics material with the coils being cooled on the mandrel and cut to length before being discharged onto an accumulator tray. The coils are individually transported at high speed from a discharge edge of the tray to the insertion device where the coils are inserted into aligned holes at an edge of respective collated books for binding the books. The coils on the tray are heated by a contact heater on the surface of the tray and/or by air blown over the tray to be kept at a temperature above 25 degrees C. to improve crimping of the ends after cutting of the coil to length in the book. | 06-17-2010 |
20150110578 | Bookbinding by Inserting a Helical Plastic Coil into the Aligned Holes at the Edge of the Book - A helical coil is inserted into holes at an edge of a book by a machine which is adjustable for different diameters of coil. The face of the book sits on a platen and the coil is driven by a roller while the edge of the book is supported on a plurality of spine formers having an arced surface for shaping the edge of the book and an end of the book is engaged by a side lay member at an angle to incline the holes at the angle to receive the turns of the coil. The flat spine formers are carried on supports which rotate so as to allow the turns of the coil at the pitch angle to pass the spine formers. For different book thickness and coil diameter, the arced shape of the spine formers, the spine former angle and the lay angle are changed manually. | 04-23-2015 |
Melanie Desjarlais, Valcourt CA
Patent application number | Description | Published |
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20150314799 | SNOWMOBILE SKI ASSEMBLY - A snowmobile ski assembly has a ski defining a slot, a ski runner disposed in the slot and being translatable in the slot between a first position and a second position, and a runner adjustment assembly connected to the ski runner. The runner adjustment assembly selectively translates the ski runner between the first and second positions. A snowmobile having the snowmobile ski assembly and a ski runner are also disclosed. | 11-05-2015 |
20150314800 | SNOWMOBILE SKI RUNNER - A snowmobile ski runner has a flat ski runner body. The flat ski runner body has a generally uniform width, a front flat wall at a front thereof, and a rear flat wall at a rear thereof. The front and rear flat walls are parallel to each other. A snowmobile ski assembly having the ski runner and a snowmobile having the snowmobile ski assembly are also disclosed. | 11-05-2015 |
Paul Daniel Desjarlais, London CA
Patent application number | Description | Published |
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20140349255 | OPERATOR COMPETENCY MANAGEMENT - A method of operator competency management includes providing a computing system having a processor running a software application. The software application implements an Operator Competency Model (OCM) which includes a simulated competency exercise including a plurality of simulated tasks for an operator in a processing facility running a physical process, wherein a competency for each simulated task is mapped to an assessment tool, wherein the assessment tools collectively include at least one subjective assessment tool and at least one automatically generated assessment tool. Responsive to the operator performing the simulated competency exercise, the performance of the operator is evaluated using respective ones of the assessment tools for the simulated tasks to generate competency data for the operator. The competency data includes an automatically generated portion corresponding to data generated by the automatically generated assessment tool and a subjective assessment portion corresponding to data generated by the subjective assessment tool. | 11-27-2014 |
Pierre Desjarlais, Boisbriand CA
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20130277257 | Article and Method for Storage and Transport of Painting Implements During Use - Painters employ multiple painting implements during painting which must be moved around as they move or stored during painting as activities are paused temporarily. Accordingly it would be beneficial to provide a painting transportation and storage system that met such requirements. However, as painters seek to minimize expenses by buying those paint trays on special offer, disposable paint tray liners, quart or gallon paint cans for small painting jobs, etc. it would be beneficial for such a system to provide flexibility in handling paint cans as well as paint trays, different sizes of paint cans, variations in paint tray dimensions, etc as well as providing an easily maneuvered system during their painting session to reflect their motion and areas being painted that can be quickly closed at the end of a painting session or their change of paint. | 10-24-2013 |
Renee L. Desjarlais, Saint Davids, PA US
Patent application number | Description | Published |
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20110152287 | SUBSTITUTED BENZOTHIAZOLE AND BENZOXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 - The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1. | 06-23-2011 |
20110152321 | BICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF DPP-1 - The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1. | 06-23-2011 |
20110224209 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) - The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1. | 09-15-2011 |
Renee Louise Desjarlais, Saint Davids, PA US
Patent application number | Description | Published |
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20080275031 | Inhibitors of C-FMS Kinase - The invention is directed to compounds of Formula I: | 11-06-2008 |
20110195960 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 08-11-2011 |
20140005225 | METHOD OF INHIBITING C-KIT KINASE | 01-02-2014 |
20140148448 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 05-29-2014 |
20140200245 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 07-17-2014 |
20140243382 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 08-28-2014 |
20140329815 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 11-06-2014 |
20140378457 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 12-25-2014 |
20150051196 | INHIBITORS OF C-FMS KINASE - The invention is directed to compounds of Formula I: | 02-19-2015 |
20150094520 | METHOD OF INHIBITING C-KIT KINASE - A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to C-KIT using a compound of the present invention: | 04-02-2015 |