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Datta, CA

Abhijit Datta, San Marcos, CA US

Patent application numberDescriptionPublished
20080305507METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE - This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. The Hcy co-substrate conversion product may be assessed directly, or it may be assessed by further conversion of the Hcy co-substrate conversion product into another material by the action of one or more additional enzymes. A kit for assaying homocysteine based on the same principle is also provided.12-11-2008

Abhijit Datta, Carlsbad, CA US

Patent application numberDescriptionPublished
20080241880Methods and compositions for determination of glycated proteins - This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase.10-02-2008
20080299597METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.12-04-2008
20100025264ELECTROCHEMICAL BIOSENSOR FOR DIRECT DETERMINATION OF PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors.02-04-2010
20110189712METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.08-04-2011
20110250627METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.10-13-2011
20130078664METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.03-28-2013

Patent applications by Abhijit Datta, Carlsbad, CA US

Ajoy Datta, Fullerton, CA US

Patent application numberDescriptionPublished
20100062335BIPOLAR BATTERY - Bipolar plates for a lead acid battery and bipolar plate stack assembly comprising such plates is described. In another aspect, the subject matter describes, a lead acid battery comprising such bipolar plate stack assembly.03-11-2010
20140377626NICKEL IRON BATTERY - A Nickel iron battery using a mono-block housing that has cells with leak-proof intercell connections. The intercell connections use compressed grommets to prevent fluid transfer between the cells. Each cell generates a charge that can be connected in series or parallel as required. The cells use an electrode plate that enables a manufacturing process which yields higher efficiency, higher throughput, and significantly lower battery cost. The anode composition of the cells has iron powder to increase cathode utilization, therefore lowering cathode material usage and lowering production cost.12-25-2014

Patent applications by Ajoy Datta, Fullerton, CA US

Amlan Datta, Rancho Cucamonga, CA US

Patent application numberDescriptionPublished
20090146108Methods and Formulations for Producing Low Density Products - A method of preparing a low-density material and precursor for forming a low-density material is provided. An aqueous mixture of inorganic primary component and a blowing agent is formed, the mixture is dried and optionally ground to form an expandable precursor. Such a precursor is then fired with activation of the blowing agent being controlled such that it is activated within a predetermined optimal temperature range. Control of the blowing agent can be accomplished via a variety of means including appropriate distribution throughout the precursor, addition of a control agent into the precursor, or modification of the firing conditions such as oxygen deficient or fuel rich environment, plasma heating etc.06-11-2009
20100192808Synthetic Microspheres and Methods of Making Same - A building product incorporating synthetic microspheres having a low alkali metal oxide content is provided. The synthetic microspheres are substantially chemically inert and thus a suitable replacement for natural cenospheres, particularly in caustic environments such as cementitious mixtures. The building product can have a cementitious matrix such as a fiber cement product. The synthetic microspheres can be incorporated as a low density additive and/or a filler for the building product and/or the like.08-05-2010

Animesh Datta, San Diego, CA US

Patent application numberDescriptionPublished
20100109747Systems and Methods Using Improved Clock Gating Cells - A clock gating cell that comprises a latch in communication with an input enable logic and an output logic circuit, wherein the latch includes a pull-up and/or a pull-down circuit at an input node of the output logic circuit and circuitry preventing premature charge or discharge of the output logic circuit input node by the pull-up and/or the pull-down circuit when the clock gating cell is enabled.05-06-2010
20120210284Method and Apparatus for Characterizing and Reducing Proximity Effect on Cell Electrical Characteristics - Circuit elements are characterized for effects of proximity context on electrical characteristic. Based on the characterization, proximity context cell models, and corresponding modeled electrical characteristic values are obtained. Logic cells are characterized and modeled according to the proximity context cell models. Optionally the electrical characteristic can be time delay, leakage, dynamic power, or coupling noise among other parameters.08-16-2012
20130015882Compact and Robust Level Shifter Layout DesignAANM Datta; AnimeshAACI San DiegoAAST CAAACO USAAGP Datta; Animesh San Diego CA USAANM Goodall, III; William JamesAACI CaryAAST NCAACO USAAGP Goodall, III; William James Cary NC US - Method and apparatus for voltage level shifters (VLS) design in bulk CMOS technology. A multi-voltage circuit or VLS that operate with different voltage levels and that provides area and power savings for multi-bit implementation of level shifter design. A two-bit VLS to shift bits from a first voltage level logic to a second voltage level logic. The VLS formed with a first N-well in a substrate. The VLS formed with a second N-well in the substrate, adjacent to a side of the first N-well. The VLS formed with a third N-well in the substrate, adjacent to a side of the first N-well and opposite the second N-well. A first one-bit VLS circuit having a portion formed on the first N-well and a portion formed on the second N-well. A second bit VLS circuit having a portion formed on the first N-well and a portion formed on the third N-well.01-17-2013
20140124868SHARED-DIFFUSION STANDARD CELL ARCHITECTURE - A semiconductor standard cell includes an N-type diffusion area and a P-type diffusion area, both extending across the cell and also outside of the cell. The cell also includes a conductive gate above each diffusion area to create a semiconductive device. A pair of dummy gates are also above the N-type diffusion area and the P-type diffusion area creating a pair of dummy devices. The pair of dummy gates are disposed at opposite edges of the cell. The cell further includes a first conductive line configured to couple the dummy devices to power for disabling the dummy devices.05-08-2014
20140211893HIGH FREQUENCY SYNCHRONIZER - Techniques for resolving a metastable state in a synchronizer are described herein. In one embodiment, a circuit for resolving a metastable state in a synchronizer comprises a signal delay circuit coupled to a node of the synchronizer, wherein the signal delay circuit is configured to delay a data signal at the node to produce a delayed data signal, and a transmission circuit coupled to the signal delay circuit, wherein the transmission circuit is configured to couple the delayed data signal to the node after a delay from a first edge of a clock signal.07-31-2014
20140306735FLIP-FLOP WITH REDUCED RETENTION VOLTAGE - A circuit including a logic gate responsive to a clock signal and to a control signal. The circuit also includes a master stage of a flip-flop. The circuit further includes a slave stage of the flip-flop responsive to the master stage. The circuit further includes an inverter responsive to the logic gate and configured to output a delayed version of the clock signal. An output of the logic gate and the delayed version of the clock signal are provided to the master stage and to the slave stage of the flip-flop. The master stage is responsive to the control signal to control the slave stage.10-16-2014
20140330994SYNCHRONOUS DATA-LINK THROUGHPUT ENHANCEMENT TECHNIQUE BASED ON DATA SIGNAL DUTY-CYCLE AND PHASE MODULATION/DEMODULATION - A synchronous data-link throughput enhancement technique based on data signal duty-cycle and phase modulation demodulation is disclosed. A method includes receiving multiple bits to be transmitted, encoding the multiple bits to generate a multi-bit signal that represents the multiple bits, and transmitting, via a synchronous interface, the multi-bit signal during a time period that corresponds to one-half of a cycle of a synchronization signal.11-06-2014
20140359385CIRCUIT AND LAYOUT TECHNIQUES FOR FLOP TRAY AREA AND POWER OTIMIZATION - Techniques for reducing scan overhead in a scannable flop tray are described herein. In one embodiment, a scan circuit for a flop tray comprises a tri-state circuit configured to invert an input data signal and output the inverted data signal to an input of a flip-flop of the flop tray in a normal mode, and to block the data signal from the input of the flip-flop in a scan mode. The scan circuit also comprises a pass gate configured to pass a scan signal to the input of the flip-flop in the scan mode, and to block the scan signal from the input of the flip-flop in the normal mode.12-04-2014
20140368247NOVEL LOW OVERHEAD HOLD-VIOLATION FIXING SOLUTION USING METAL-PROGRAMABLE CELLS - Techniques for fixing hold violations using metal-programmable cells are described herein. In one embodiment, a system comprises a first flip-flop, a second flip-flop, and a data path between the first and second flip-flops. The system further comprises a metal-programmable cell connected to the data path, wherein the metal-programmable cell is programmed to implement at least one capacitor to add a capacitive load to the data path. The capacitive load adds delay to the data path that prevents a hold violation at one of the first and second flip-flops.12-18-2014
20150054567LAYOUT CONSTRUCTION FOR ADDRESSING ELECTROMIGRATION - A first interconnect on an interconnect level connects a first subset of PMOS drains together of a CMOS device. A second interconnect on the interconnect level connects a second subset of the PMOS drains together. The second subset of the PMOS drains is different than the first subset of the PMOS drains. The first interconnect and the second interconnect are disconnected on the interconnect level. A third interconnect on the interconnect level connects a first subset of NMOS drains together of the CMOS device. A fourth interconnect on the interconnect level connects a second subset of the NMOS drains together. The second subset of the NMOS drains is different than the first subset of the NMOS drains. The third interconnect and the fourth interconnect are disconnected on the interconnect level. The first, second, third, and fourth interconnects are coupled together though at least one other interconnect level.02-26-2015
20150054568LAYOUT CONSTRUCTION FOR ADDRESSING ELECTROMIGRATION - A CMOS device with a plurality of PMOS transistors each having a PMOS drain and a plurality of NMOS transistors each having an NMOS drain includes a first interconnect on an interconnect level extending in a length direction to connect the PMOS drains together. A second interconnect on the interconnect level extends in the length direction to connect the NMOS drains together. A set of interconnects on at least one additional interconnect level couple the first interconnect and the second interconnect together. A third interconnect on the interconnect level extends perpendicular to the length direction and is offset from the set of interconnects to connect the first interconnect and the second interconnect together.02-26-2015
20150221639DIGITAL CIRCUIT DESIGN WITH SEMI-CONTINUOUS DIFFUSION STANDARD CELL - A CMOS device including a standard cell includes first and second transistors with a gate between the first and second transistors. One active region extends between the first and second transistors and under the gate. In a first configuration, when drains/sources of the first and second transistors on the sides of the gate carry the same signal, the drains/sources are connected together and to the gate. In a second configuration, when a source of the first transistor on a side of the gate is connected to a source voltage and a drain/source of the second transistor on the other side of the gate carries a signal, the source of the first transistor is connected to the gate. In a third configuration, when sources of the first and second transistors on the sides of the gate are connected to a source voltage, the gate floats.08-06-2015
20150249076HIGH PERFORMANCE STANDARD CELL - A transistor cell is provided that includes a dummy gate overlaying a continuous oxide definition (OD) region. A first portion of the OD region adjacent a first side of the dummy forms the drain. The cell includes a local interconnect structure that couples the dummy gate and a portion of the OD region adjacent a second opposing side of the dummy gate to a source voltage.09-03-2015
20160124043CIRCUIT TECHNIQUES FOR EFFICIENT SCAN HOLD PATH DESIGN - In one embodiment, a method for signal delay in a scan path comprises, in a scan mode, delaying a scan signal in the scan path by propagating the scan signal through a plurality of delay devices coupled in series, wherein a first one of the delay devices is powered by a first voltage, a second one of the delay devices is powered by a second voltage, and the second voltage is greater than the first voltage. The method also comprises, in a functional mode, disabling the delay devices.05-05-2016

Patent applications by Animesh Datta, San Diego, CA US

Anup K. Datta, San Diego, CA US

Patent application numberDescriptionPublished
20090208533NEISSERIA MENINGITIDIS SEROGROUP A CAPSULAR POLYSACCHARIDE ACETYLTRANSFERASE, METHODS AND COMPOSITIONS - Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A 08-20-2009

Arindom Datta, Goleta, CA US

Patent application numberDescriptionPublished
20100083801EMBEDDED THIN FILM SENSORS AND METHODS OF EMBEDDING THIN FILM SENSORS - An embedded sensor or other desired device is provided within a completed structure through a solid-state bonding process (e.g., by diffusion bonding) and/or through a dynamic bonding process (e.g., by brazing). The embedded sensor or other desired device is provided on a substrate through any know or later-developed method (e.g., a photolithography or conductive ink printing process). A cover is then bonded to the substrate using a solid-state bonding process and/or a dynamic bonding process. The solid-state bonding process and/or dynamic bonding process may include providing heat and/or pressure to the substrate, the cover and/or a bonding agent (e.g., a filler metal or alloy) to bond the substrate and the cover together.04-08-2010

Avijit Datta, Chatsworth, CA US

Patent application numberDescriptionPublished
20130185094Automated ICD-9 To ICD-10 Code Conversion System - Code conversion from ICD-9 data to ICD-10 codes is semi-automatic. Codes that cannot readily be converted in a fully automatic environment are referred to an interactive code assignment engine, which retrieves information from clinical databases to suggest codes to a human worker.07-18-2013

Brij Datta, Cupertino, CA US

Patent application numberDescriptionPublished
20160035547MAGNETRON ASSEMBLY FOR PHYSICAL VAPOR DEPOSITION CHAMBER - Methods and apparatus for a magnetron assembly are provided herein. In some embodiments, a magnetron assembly includes a shunt plate having a central axis and rotatable about the central axis, a closed loop magnetic pole coupled to a first surface of the shunt plate and disposed 360 degrees along a peripheral edge of the shunt plate, and an open loop magnetic pole coupled at a the first surface of the shunt plate wherein the open loop magnetic pole comprises two rows of magnets disposed about the central axis.02-04-2016

Deepshikha Datta, South Pasadena, CA US

Patent application numberDescriptionPublished
20090035836MODULATING PH-SENSITIVE BINDING USING NON-NATURAL AMINO ACIDS - The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional fragment, derivative, etc.). The invention also relates to specific uses in regulating pH-sensitive binding of antibodies to tumor site, by conferring enhanced tumor-specificity/selectivity. In that embodiment, the non-natural amino acids preferably have desirable side-chain pKa's, such that at below physiological pH (e.g. about pH 6.3-6.5) the non-natural amino acid confer enhanced binding to tumor antigens in acidic environments. Such non-natural amino acids can be incorporated by any suitable means, such as by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs (e.g. the degenerate codon orthogonal system.02-05-2009

Patent applications by Deepshikha Datta, South Pasadena, CA US

Deepshikha Datta, San Francisco, CA US

Patent application numberDescriptionPublished
20090010966MODIFIED DIPHTHERIA TOXINS - The present application relates to compositions of modified diphtheria toxin and fusion proteins containing modified diphtheria toxin that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome, as well as methods of making the compositions. The present application also relates to a polypeptide toxophore from a modified diphtheria toxin, where the modification is at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of an unmodified native diphtheria toxin. Also described are fusion proteins which contain a modified diphtheria toxin and a non-diphtheria toxin fragment which contains a cell binding portion. The modified diphtheria toxins described can be used for the treatment of a malignant disease or a non-malignant disease.01-08-2009
20090041797MODIFIED TOXINS - The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.02-12-2009
20090221500MODIFIED TOXINS - The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.09-03-2009
20100254943AMINO ACID SUBSTITUTED MOLECULES - The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.10-07-2010

Diptish Datta, San Jose, CA US

Patent application numberDescriptionPublished
20140317743METHOD AND APPARATUS FOR MANAGEMENT AND TROUBLESHOOTING OF A PROCESSING SYSTEM - The present invention includes an apparatus connected to a processing system including a data collector to gather and store data regarding operation of the processing system, a device relationship manager to send data regarding the operation of the processing system to a remote administrative console, and a security policy manager to control the sending of data regarding the operation of the processing system by the device relationship manager to the remote administrative console based on a security policy.10-23-2014

Esha Datta, West Hills, CA US

Patent application numberDescriptionPublished
20100010641EXTERNAL WALKING ASSIST DEVICE FOR THOSE WITH LOWER LEG INJURIES - A walking assist device, which is to be worn on a person's leg, includes a shank link, a thigh member, and a knee mechanism. The thigh member is in contact with the person's thigh when the device is worn on the person's leg. The knee mechanism rotatably connects the shank link to the thigh member. When the shank link is in contact with the ground, the knee mechanism is configured to resist the rotation of the shank link relative to the thigh member to prevent the person's foot from contacting the ground and reduces ground reaction forces entering the person's foot.01-14-2010

Keshava Datta, Chino Hills, CA US

Patent application numberDescriptionPublished
20090318793Disposable Patch and Reusable Sensor Assembly for Use in Medical Device Localization and Mapping Systems - An patch and sensor assembly for use in an EP mapping system has two portions: a reusable portion and a disposable portion. The reusable portion houses the biosensors used in magnetic based location and mapping systems and the electrical lead necessary to communicate between the biosensor and the mapping system. The reusable portion may also contain a portion of the electrode necessary to receive electrical signals from the body of the patient. The disposable portion of the patch and sensor assembly contains an adhesive covered flexible patch having at least a portion of the electrode used to receive electrical signals form the body of the patient and may contain the electrical lead necessary to communicate such an electrical signal to the mapping system. The disposable portion contains a receptacle adapted to receive and mechanically secure the reusable portion to the disposable portion of the assembly. Such a patch and sensor assembly is useful in hybrid magnetic and impedance based location and mapping systems such as those used in electrophysiology.12-24-2009
20090318796Patch and sensor assembly for use in medical device localization and mapping systems - An patch and sensor assembly for use in an EP mapping system has two portions: a reusable portion and a disposable portion. The reusable portion houses the biosensors used in magnetic based location and mapping systems and the electrical lead necessary to communicate between the biosensor and the mapping system. The reusable portion may also contain a portion of the electrode necessary to receive electrical signals from the body of the patient. The disposable portion of the patch and sensor assembly contains an adhesive covered flexible patch having at least a portion of the electrode used to receive electrical signals form the body of the patient and may contain the electrical lead necessary to communicate such an electrical signal to the mapping system. The disposable portion contains a receptacle adapted to receive and mechanically secure the reusable portion to the disposable portion of the assembly. Such a patch and sensor assembly is useful in hybrid magnetic and impedance based location and mapping systems such as those used in electrophysiology.12-24-2009
20100168676CATHETER WITH PROTECTIVE BARRIER MEMBER - A device that shields internal organs and tissues from medical procedures performed within a patient's body, especially in the chest cavity where ablation and related procedures are performed in or near the heart, includes a catheter body, a distal section, and a barrier member that can be inflated with fluid to act as a barrier to extreme temperatures and physical trauma, and be deflated to a smaller size to facilitate entry and removal from the patient's chest cavity. In a more detailed embodiment, the barrier member is a balloon that can protects the esophagus, which can be provided with folds and shape memory elements so that the balloon expands and collapses into predetermined configurations. Fluid is fed to and drawn from the barrier member via an irrigation tubing that extends along a catheter shaft and is in communication with a lumen of a deflectable tubing section that extends through an interior cavity of the barrier member. The catheter can be adapted for uni- or bi-directional deflection.07-01-2010
20120165644SINGLE RADIO-TRANSPARENT CONNECTOR FOR MULTI-FUNCTIONAL REFERENCE PATCH - A patch and sensor assembly has a magnetic-based biosensor is housed in a reusable portion that connects to the mapping and localization system via biosensor wires, and a disposable portion provides an electrode layer through which impedance-based signals are transmitted to the mapping and localization system via ACL wires, wherein the biosensor wires and the ACL wires extend through a single cable exiting the reusable portion. In one embodiment, the disposable portion includes an adhesive layer for adhering the electrode layer to a patient's body where the electrode layer is disposed on the adhesive hydrogel layer. The disposable portion also includes a foam layer disposed on the electrode layer, and an engagement element adapted to detachably receive at least a portion of a housing of the resuable portion. In one embodiment, the reusable portion includes a housing defining a sealed interior volume in which a magnetic-based biosensor is provided with biosensor wires that exit the reusable portion. The housing is also adapted to carry and/or provide support to an ACL contact member that is responsive to the electrode layer of the disposable portion, and ACL wires for the ACL contact member that exit the reusable portion. Advantageously, the biosensor wires and the ACL wires extend through a single cable to a mapping and localization system.06-28-2012
20130172813MEDICAL DEVICE CONTROL HANDLE WITH MULTIPLE PULLER WIRES - A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter.07-04-2013
20130211399ELECTROPHYSIOLOGY CATHETER WITH MECHANICAL USE LIMITER - A catheter for the treatment of tissue, particularly for the treatment of cardiac tissue to alleviate cardiac arrhythmias includes a connector having mechanical use limiter that may be placed in the handle of the catheter or at any point along the electrical connection pathway to an electro-anatomic mapping system and/or ablation system. The mechanical use limiter has a counter wheel and locking pin which when engaged disables the reconnection of the connector to any mated connector after a predetermined number of uses.08-15-2013
20130231657CATHETER FOR TREATMENT OF ATRIAL FLUTTER HAVING SINGLE ACTION DUAL DEFLECTION MECHANISM - A catheter and method for the treatment of a patient having atrial flutter or other arrhythmia comprises an elongated catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. Further it has a distal tip section comprising a flexible tubing having a proximal end and a distal end and a plurality of lumens extending therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The tip section further comprises a nitinol tube having slots formed therein which causes the distal tip section to deflect using the same puller-wire action used to cause the deflectable catheter to deflect at a point proximal to the distal tip section.09-05-2013
20130296729CATHETER HAVING TWO-PIECE CONNECTOR FOR A SPLIT HANDLE ASSEMBLY - A catheter and method for the treatment of a patient having atrial flutter or other arrhythmia comprises an elongated catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. Further it has a distal tip section comprising a flexible tubing having a proximal end and a distal end and a plurality of lumens extending therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The tip section further comprises a nitinol tube having slots formed therein which causes the distal tip section to deflect using the same puller-wire action used to cause the deflectable catheter to deflect at a point proximal to the distal tip section.11-07-2013
20160038718MEDICAL DEVICE CONTROL HANDLE WITH MULTIPLE PULLER WIRES - A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter.02-11-2016
20160045711MEDICAL DEVICE CONTROL HANDLE WITH MULTIPLE PULLER WIRES - A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter.02-18-2016
20160100885CATHETER FOR TREATMENT OF ATRIAL FLUTTER HAVING SINGLE ACTION DUAL DEFLECTION MECHANISM - A catheter and method for the treatment of a patient having atrial flutter or other arrhythmia comprises an elongated catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. Further it has a distal tip section comprising a flexible tubing having a proximal end and a distal end and a plurality of lumens extending therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The tip section further comprises a nitinol tube having slots formed therein which causes the distal tip section to deflect using the same puller-wire action used to cause the deflectable catheter to deflect at a point proximal to the distal tip section.04-14-2016

Patent applications by Keshava Datta, Chino Hills, CA US

Keshava Datta, Pasadena, CA US

Patent application numberDescriptionPublished
20090088697CONTROL HANDLE WITH DEVICE ADVANCING MECHANISM - A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device. The device may be a stiffener wire, a needle or any other device suitable for advancement and retraction in a catheter.04-02-2009
20090281453MRI Biopsy Apparatus Incorporating a Sleeve and Multi-Function Obturator - A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and in particular a sleeve, to a biopsy site of suspicious tissues or lesions. A depth stop enhances accurate insertion, and prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imageability, to enhance vacuum and pressure assist therethrough, and marker deployment etc.11-12-2009
20110184385CONTROL HANDLE WITH DEVICE ADVANCING MECHANISM - A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device. The device may be a stiffener wire, a needle or any other device suitable for advancement and retraction in a catheter.07-28-2011
20130231586MRI BIOPSY APPARATUS INCORPORATING A SLEEVE AND MULTI-FUNCTION OBTURATOR - An apparatus for use with a minimally invasive medical procedure into human breast tissue includes a cannula and an obturator. The cannula includes an open distal end, a lateral opening proximate to the open distal end, and a longitudinal lumen communicating with the lateral opening and the open distal end. The lumen has a non-circular cross-section. The obturator is sized for insertion into the cannula. The obturator has a distal end extending from the open distal end of the cannula when the obturator is inserted fully into the cannula. The obturator has a recess proximate of the distal end of the obturator. The recess is positioned along a portion of the length of the obturator to align with the lateral opening of the cannula when the obturator is inserted fully into the cannula.09-05-2013
20140107582CONTROL HANDLE WITH DEVICE ADVANCING MECHANISM - A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device. The device may be a stiffener wire, a needle or any other device suitable for advancement and retraction in a catheter.04-17-2014

Patent applications by Keshava Datta, Pasadena, CA US

Kunal Datta, Los Angeles, CA US

Patent application numberDescriptionPublished
20160049910DOHERTY POWER AMPLIFIER COMBINER WITH TUNABLE IMPEDANCE TERMINATION CIRCUIT - Doherty power amplifier combiner with tunable impedance termination circuit. A signal combiner can include a balun transformer circuit having a first coil and a second coil. The first coil can be implemented between a first port and a second port. The second coil can be implemented between a third port and a fourth port. The first port and the third port can be coupled by a first capacitor. The second port and fourth port can be coupled by a second capacitor. The first port can be configured to receive a first signal. The fourth port can be configured to receive a second signal. The second port can be configured to yield a combination of the first signal and the second signal. The signal combiner can include a termination circuit that couples the third port to a ground. The termination circuit can include a tunable impedance circuit.02-18-2016
20160118944DOHERTY POWER AMPLIFIER WITH TUNABLE INPUT NETWORK - Doherty power amplifier with tunable input network. An input network for a Doherty power amplifier can include a splitter circuit configured to receive a radio-frequency (RF) signal and split the RF signal into a first portion along a first path to a carrier amplifier of the Doherty power amplifier and a second portion along a second path to a peaking amplifier of the Doherty power amplifier. The input network can further include a tunable input circuit implemented along either or both of the first path and second path. The tunable input circuit can be configured to provide control of the amplitude and phase of either or both of the first portion and second portion.04-28-2016

Madhav Datta, Milpitas, CA US

Patent application numberDescriptionPublished
20080210405Fabrication of high surface to volume ratio structures and their integration in microheat exchangers for liquid cooling systems - An structure and method of manufacturing a microstructure for use in a heat exchanger is disclosed. The heat exchanger comprises a manifold layer and an microstructured region. The manifold layer comprises a structure to deliver fluid to the microstructured region. The microstructured region is formed from multiple windowed layers formed from heat conductive layers through which a plurality of microscaled apertures have been formed by a wet etching process. The plurality of windowed layers are then coupled together to form a composite microstructure.09-04-2008
20100032143 MICROHEAT EXCHANGER FOR LASER DIODE COOLING - A microheat exchanging assembly is configured to cool one or more heat generating devices, such as integrated circuits or laser diodes. The microheat exchanging assembly includes a first ceramic assembly thermally coupled to a first surface, and in cases, a second ceramic assembly thermally coupled to a second surface. The ceramic assembly includes one or more electrically and thermally conductive pads to be thermally coupled to a heat generating device, each conductive pad is electrically isolated from each other. The ceramic assembly includes a ceramic layer to provide this electrical isolation. A top surface and a bottom surface of the ceramic layer are each bonded to a conductive layer, such as copper, using an intermediate joining material. A brazing process is performed to bond the ceramic layer to the conductive layer via a joining layer. The joining layer is a composite of the joining material, the ceramic layer, and the conductive layer.02-11-2010
20100035024BONDED METAL AND CERAMIC PLATES FOR THERMAL MANAGEMENT OF OPTICAL AND ELECTRONIC DEVICES - A ceramic assembly includes one or more electrically and thermally conductive pads to be thermally coupled to a heat generating device, each conductive pad is electrically isolated from each other. The ceramic assembly includes a ceramic layer to provide this electrical isolation. The ceramic layer has high thermal conductivity and high electrical resistivity. A top surface and a bottom surface of the ceramic layer are each bonded to a conductive layer, such as copper, using an intermediate joining material. A brazing process is performed to bond the ceramic layer to the conductive layer via a joining layer. The joining layer is a composite of the joining material, the ceramic layer, and the conductive layer. The top conductive layer and the joining layer are etched to form the electrically isolated conductive pads. The conductive layers are bonded to the ceramic layer using a bare ceramic approach or a metallized ceramic approach.02-11-2010
20110073292FABRICATION OF HIGH SURFACE AREA, HIGH ASPECT RATIO MINI-CHANNELS AND THEIR APPLICATION IN LIQUID COOLING SYSTEMS - The present invention provides methods and apparatuses which achieve high heat transfer in a fluid cooling system, and which do so with a small pressure drop across the system. The present invention teaches the use of wall features on the fins of a heat exchanger to cool fluid in a fluid cooling system. The present invention also discloses high aspect ratio, high surface area structures applicable in micro-heat exchangers for fluid cooling systems and cost effective methods for manufacturing the same.03-31-2011

Patent applications by Madhav Datta, Milpitas, CA US

Mainak Datta, Fremont, CA US

Patent application numberDescriptionPublished
20090260004COMPUTER PROGRAM UPDATES FOR MOBILE COMPUTING DEVICE - A system and method for updating a computer program on a mobile computing device comprises uploading of packages to a repository, wherein each package comprises update data for a different portion of the computer program, a server identifying portions of the computer program to be updated on a device based on comparing information reported by the device and metadata about packages in the repository and a download server configured to wirelessly download the packages to the mobile computing device. The device may report back installation status to a server.10-15-2009

Paliab Datta, San Jose, CA US

Patent application numberDescriptionPublished
20140180985MAPPING NEURAL DYNAMICS OF A NEURAL MODEL ON TO A COARSELY GRAINED LOOK-UP TABLE - Embodiments of the invention relate to mapping neural dynamics of a neural model on to a lookup table. One embodiment comprises defining a phase plane for a neural model. The phase plane represents neural dynamics of the neural model. The phase plane is coarsely sampled to obtain state transition information for multiple neuronal states. The state transition information is mapped on to a lookup table.06-26-2014

Pallab Datta, San Jose, CA US

Patent application numberDescriptionPublished
20130339281MULTI-PROCESSOR CORTICAL SIMULATIONS WITH RECIPROCAL CONNECTIONS WITH SHARED WEIGHTS - Embodiments of the invention relate to distributed simulation frameworks that provide reciprocal communication. One embodiment comprises interconnecting neuron groups on different processors via a plurality of reciprocal communication pathways, and facilitating the exchange of reciprocal spiking communication between two different processors using at least one Ineuron module. Each processor includes at least one neuron group. Each neuron group includes at least one electronic neuron.12-19-2013
20140180988HARDWARE ARCHITECTURE FOR SIMULATING A NEURAL NETWORK OF NEURONS - Embodiments of the invention relate to a neural network system for simulating neurons of a neural model. One embodiment comprises a memory device that maintains neuronal states for multiple neurons, a lookup table that maintains state transition information for multiple neuronal states, and a controller unit that manages the memory device. The controller unit updates a neuronal state for each neuron based on incoming spike events targeting said neuron and state transition information corresponding to said neuronal state.06-26-2014
20150227558MAPPING NEURAL DYNAMICS OF A NEURAL MODEL ON TO A COARSELY GRAINED LOOK-UP TABLE - Embodiments of the invention relate to mapping neural dynamics of a neural model on to a lookup table. One embodiment comprises defining a phase plane for a neural model. The phase plane represents neural dynamics of the neural model. The phase plane is coarsely sampled to obtain state transition information for multiple neuronal states. The state transition information is mapped on to a lookup table.08-13-2015
20150347870SCENE UNDERSTANDING USING A NEUROSYNAPTIC SYSTEM - Embodiments of the invention provide a method for scene understanding based on a sequence of image frames. The method comprises converting each pixel of each image frame to neural spikes, and extracting features from the sequence of image frames by processing neural spikes corresponding to pixels of the sequence of image frames. The method further comprises encoding the extracted features as neural spikes, and classifying the extracted features.12-03-2015
20160034808HARDWARE ARCHITECTURE FOR SIMULATING A NEURAL NETWORK OF NEURONS - Embodiments of the invention relate to a neural network system for simulating neurons of a neural model. One embodiment comprises a memory device that maintains neuronal states for multiple neurons, a lookup table that maintains state transition information for multiple neuronal states, and a controller unit that manages the memory device. The controller unit updates a neuronal state for each neuron based on incoming spike events targeting said neuron and state transition information corresponding to said neuronal state.02-04-2016
20160125289MAPPING GRAPHS ONTO CORE-BASED NEUROMORPHIC ARCHITECTURES - Embodiments of the invention provide a method for mapping a bipartite graph onto a neuromorphic architecture comprising of a plurality of interconnected neuromorphic core circuits. The graph includes a set of source nodes and a set of target nodes. The method comprises, for each source node, creating a corresponding splitter construct configured to duplicate input. Each splitter construct comprises a first portion of a core circuit. The method further comprises, for each target node, creating a corresponding merger construct configured to combine input. Each merger construct comprises a second portion of a core circuit. Source nodes and target nodes are connected based on a permutation of an interconnect network interconnecting the core circuits.05-05-2016

Patent applications by Pallab Datta, San Jose, CA US

Piew Datta, Carlsbad, CA US

Patent application numberDescriptionPublished
20130231983ESTIMATING BUSINESS TARGETS - A method for generating business targets includes accessing data (09-05-2013
20140278774IN THE MARKET MODEL SYSTEMS AND METHODS - One embodiment includes a system and method for identifying potential consumer candidates in the market for products or services is disclosed. The system and method may predict whether a consumer is likely to be “in the market” for a product or service can be achieved by utilizing an “in the market” system to determine which groups of consumers will likely respond to solicitation or be in need of a product or service. The system and method may provide data that allows businesses to quickly determine consumer groups that will likely utilize their services or purchase their products.09-18-2014

Ramyanshu Datta, San Jose, CA US

Patent application numberDescriptionPublished
20110298488THROUGH CARRIER DUAL SIDE LOOP-BACK TESTING OF TSV DIE AFTER DIE ATTACH TO SUBSTRATE - A method of testing electronic assemblies including singulated TSV die attached to a ML package substrate, on a substrate carrier. The substrate carrier includes through-holes for allowing probe contact to the BGA substrate pads on a bottomside of the package substrate that are coupled to the frontside of the TSVs. Contactable TSV tips on the bottomside of the TSV die are contacted with a topside coupler that includes a pattern of coupling terminals that matches a layout of at least a portion of the TSV tips or pads coupled to the TSV tips. The topside coupler electrically connects pairs of coupling terminals to provide a plurality of TSV loop back paths. The BGA substrate pads are contacted with a plurality of probes tips that extend through the through-holes to couple to the frontside of the TSVs. Electrical testing is performed across the electronic assembly to obtain at least one test parameter.12-08-2011
20110304349LATERAL COUPLING ENABLED TOPSIDE ONLY DUAL-SIDE TESTING OF TSV DIE ATTACHED TO PACKAGE SUBSTRATE - A method of topside only dual-side testing of an electronic assembly includes providing a singulated through substrate via (TSV) die flip chip attached to a die support including a package substrate. The TSVs on the TSV die extend from its frontside to contactable TSV tips on its bottomside. The TSVs on the frontside of the TSV die are coupled to embedded topside substrate pads on a top surface of the ML substrate. The die support includes lateral coupling paths between at least a portion of the embedded topside substrate pads and lateral topside pads on a topside surface of the die support lateral to the die area. The contactable TSV tips are contacted with probes to provide a first topside connection to the TSVs, and the lateral topside pads are contacted with probes to provide a second topside connection. Dual-side testing across the electronic assembly is performed using the first and second topside connections.12-15-2011

Ruchira S. Datta, Mountain View, CA US

Patent application numberDescriptionPublished
20120109978AUGMENTING QUERIES WITH SYNONYMS FROM SYNONYMS MAP - Methods, systems, and apparatus, including computer program products, operable to perform operations including receiving through a user interface with an interface language a search query having query terms; using the interface language to select one or more mappings and using the selected mappings to simplify each query term; and applying each simplified query term to a synonyms map to identify possible synonyms with which to augment the search query. In alternative embodiments, the operations include generating a synonyms map from a corpus of documents; where the synonyms map maps each of multiple keys to one or more corresponding variants, where each variant is associated with one or more of document languages. In alternative embodiments, the operations include generating a synonyms map from documents by applying document language-dependent mappings to words in the documents to generate keys for the map.05-03-2012

Salil Datta, Cupertino, CA US

Patent application numberDescriptionPublished
20130262525Discovering Pivot Type Relationships Between Database Objects - According to a present invention embodiment, a system determines a relationship between source and target database tables, and includes a computer system including at least one processor. Potential pivot keys of the target database table are determined, and maps are created for each potential pivot key between the database tables based on distinct values. Transformations for each map are generated that enable target data to be produced from source data. The transformations for each potential pivot key are analyzed and the potential pivot key with the transformations that generate the greatest amount of matching data is selected as the resulting pivot key. The database table columns corresponding to the resulting pivot key are determined to be associated by the relationship. Embodiments of the present invention further include a method and computer program product for determining a relationship between source and target database tables in substantially the same manner described above.10-03-2013

Santanu Datta, Fremont, CA US

Patent application numberDescriptionPublished
20140281252STATEMENT CACHE AUTO-TUNING - Disclosed are methods and apparatuses that implement automatic resizing of statement caches in response to cache metrics. One embodiment provides an approach for periodically calculating a session eligibility index for each session cache, wherein the session eligibility index indicates the priority level of the session cache for resizing, and selecting and resizing one or more cache sessions based at least in part on the session eligibility index.09-18-2014

Saurabh Datta, Pleasanton, CA US

Patent application numberDescriptionPublished
20120130288ULTRASOUND-MEDIATED INDUCEMENT, DETECTION, AND ENHANCEMENT OF STABLE CAVITATION - Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.05-24-2012
20130144161Flow Quantification in Ultrasound Using Conditional Random Fields with Global Consistency - Velocities are unaliased using conditional random fields. To constrain the energy minimization function, a global term includes a measure of a level of aliasing. In one example, the measure of the level of aliasing is based on a change in volume, such as the volume of the left ventricle. The unaliasing is performed along one or more surfaces, such as surfaces intersecting the mitral annulus and the left ventricle outflow tract. The anatomy used is identified and/or tracked using one or more machine-learnt detectors. Both B-mode and velocity information may be used for detecting the anatomy.06-06-2013
20140052001Mitral Valve Detection for Transthoracic Echocardiography - A mitral valve is detected in transthoracic echocardiography. The ultrasound transducer is positioned against the chest of the patient rather than being inserted within the patient. While data acquired from such scanning may be noisier or have less resolution, the mitral valve may still be automatically detected. Using both B-mode data representing tissue as well as flow data representing the regurgitant jet, the mitral valve may be detected automatically with a machine-learnt classifier. A series of classifiers may be used, such as determining a position and orientation of a valve region with one classifier, determining a regurgitant orifice with another classifier, and locating mitral valve anatomy with a third classifier. One or more features for some of the classifiers may be calculated based on the orientation of the valve region.02-20-2014

Patent applications by Saurabh Datta, Pleasanton, CA US

Saurabh Datta, Cupertino, CA US

Patent application numberDescriptionPublished
20110144495Perfusion Imaging of a Volume in Medical Diagnostic Ultrasound - A volume is scanned with ultrasound for determining perfusion. A volume is scanned with a more rapid technique for tracking a sub-volume, and the tracked sub-volume is scanned for contrast agent detection with a less rapid technique. For example, a single pulse technique or B-mode scanning is used to track a region over one or more cycles, the location of the tracked region is predicted, and multiple pulse contrast agent detection is performed for the sub-volume at the predicted location. The combinations of scanning provide for real-time or higher temporal resolution reperfusion information at the appropriate tissue. Using a separate scan for motion tracking may provide a more robust prediction of the sub-volume location and a better visualization of the results (e.g., orientation within the organ). In other embodiments, tracking is based on a B mode image derived from the multi-pulse data.06-16-2011
20110208056Volumetric Quantification for Ultrasound Diagnostic Imaging - Volumetric quantification is provided in medical diagnostic ultrasound. By acquiring both B-mode and color flow data without stitching or acquiring in real-time at tens of volumes a second, more reliable quantification may be provided. Using multiple regions of interest in a volume may allow for more accurate and/or complete flow information, such as averaging flow from different locations in the same structure (e.g., use preservation of mass to acquire multiple measures of the same flow).08-25-2011
20110218435Prediction-Based Flow Estimation for Ultrasound Diagnostic Imaging - Flow estimation is provided. The flow is predicted. A mathematical, logic, machine learning or other model is used to predict flow. For example, the boundary conditions associated with a previous flow, the previous flow, and current boundary conditions are used to predict the current flow. The current flow is corrected using the predicted flow. Velocities may be unaliased based on the predicted flow. The predicted flow may replace the current flow. Prediction may additionally or alternatively be used in determination of lateral or elevational flow.09-08-2011
20110301466CARDIAC FLOW QUANTIFICATION WITH VOLUMETRIC IMAGING DATA - A method quantifies cardiac volume flow for an imaging sequence. The method includes receiving data representing three-dimensions and color Doppler flow data over a plurality of frames, constructing a ventricular model based on the data representing three-dimensions for the plurality of frames, the ventricular model including a sampling plane configured to measure the cardiac volume flow, computing volume flow samples based on the sampling plane and the color Doppler flow data, and correcting the volume flow samples for aliasing based on volumetric change in the ventricular model between successive frames of the plurality of frames.12-08-2011
20120215110Multiple Beam Spectral Doppler in Medical Diagnostic Ultrasound Imaging - Spatially distinct Spectral Doppler information is acquired. Spatially distinct transmit beams are formed at a same time or in parallel. One or more receive beams are formed in response to each transmit beam, providing samples for a plurality of laterally spaced locations. A spectrum is determined for each of a plurality of spatial locations. In another approach, samples are acquired for different regions at different times. The scanning for each region is interleaved based on the anatomic operation. Since spectral estimation relies on a time-continuous series of transmission and reception, the scanning for a region occurs over a sufficient period for spectral estimation before the scanning for a different region occurs. By using anatomic operation, sufficient time is provided for spectral estimation. Due to anatomic operation, different regions are associated with flow at different times.08-23-2012
20130245441Pressure-Volume with Medical Diagnostic Ultrasound Imaging - Pressure-volume analysis is provided in medical diagnostic ultrasound imaging. The heart of a patient is scanned multiple times during a given cycle. B-mode and flow information are obtained for various times. The flow information is used to estimate pressure over time. A reference pressure, such as from a cuff, may be used to calibrate the pressure waveform. The B-mode information is used to determine a heart volume over time, such as a left ventricle volume over time. The heart volume over time and pressure over time are plotted, providing a pressure-volume loop. The pressure-volume loop is determined non-invasively with ultrasound.09-19-2013

Patent applications by Saurabh Datta, Cupertino, CA US

Somalee Datta, Fremont, CA US

Patent application numberDescriptionPublished
20160122333MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN - There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.05-05-2016

Somalee Datta, Sunnyvale, CA US

Patent application numberDescriptionPublished
20130040950MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN - There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.02-14-2013
20150211079METHOD FOR DETECTING A MINORITY GENOTYPE - Disclosed are methods for detecting a minority genotype of a target nucleic acid. The disclosed method generally includes the steps of (a) deep sequencing at least a portion of the target nucleic acid; (b) using the deep sequencing results of (a) to detect the presence of variant nucleobases at one or more nucleotide reference positions within the target nucleic acid; (c) using the variant detection results generated in step (b) to perform a statistical analysis of whether the variants are significant; and (d) using the variant detection and variant significance results generated in steps (b) and (c) to perform a statistical analysis of whether a subset of sequences together exhibit a common set of significant variants.07-30-2015

Subrata Datta, San Diego, CA US

Patent application numberDescriptionPublished
20110069836OFF-LINE CONTENT DELIVERY SYSTEM WITH LAYERED ENCRYPTION - Systems and methods are described for over-encrypting symmetrically pre-encrypted content for off-line delivery to playback devices using portable media drives in accordance with embodiments of the invention. One embodiment of the method of the invention includes symmetrically pre-encrypting the content, receiving a request to issue content for playback on at least one playback device associated with a user account, where each playback device includes a processor containing a private key assigned to the playback device by a conditional access system, generating a content key and over-encrypting at least a portion of the symmetrically pre-encrypted content in response to the request, obtaining a public key for each playback device, encrypting a copy of the content key using the public key of each playback device associated with the user account, and delivering the over-encrypted content and the at least one encrypted copy of the content key to a playback device associated with the user account.03-24-2011

Sudip Datta, Foster City, CA US

Patent application numberDescriptionPublished
20160092535METHOD AND SYSTEM FOR IMPLEMENTING A UNIFIED DB CLONE SYSTEM - Disclosed are a system, method, and computer program product for a unified system for implementing clones. The unified system includes the appropriate infrastructure to create, maintain, and administer clones and supporting data sources in the computing environment. In addition, a user interface is provided that is capable of visually displaying relationships and lineages of sources and clones in the system. The user interface provides functionality to select any given object, and to trace its parent-child relationships to highlight its related parent and/or child source/clone.03-31-2016

Supratim Datta, Berkeley, CA US

Patent application numberDescriptionPublished
20120129227THERMOSTABLE CELLULASES, AND MUTANTS THEREOF, CAPABLE OF HYDROLYZING CELLULOSE IN IONIC LIQUID - The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introducing a thermostable cellulase to the solution, such that the cellulose is hydrolyzed by the cellulase. The present invention also provides for a 05-24-2012
20130023015Useful halophilic, thermostable and ionic liquids tolerant cellulases - The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a 01-24-2013

Supratim Datta, Oakland, CA US

Patent application numberDescriptionPublished
20110207182Novel thermophilic cellobiohydrolase - The present invention provides for a composition comprising a polypeptide comprising a first amino acid sequence having at least 70% identity with the amino acid sequence of Csac GH5 wherein said first amino acid sequence has a thermostable or thermophilic cellobiohydrolase (CBH) or exoglucanase activity.08-25-2011
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