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| 20080241880 | Methods and compositions for determination of glycated proteins - This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase. | 10-02-2008 |
| 20080299597 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention. | 12-04-2008 |
| 20100025264 | ELECTROCHEMICAL BIOSENSOR FOR DIRECT DETERMINATION OF PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors. | 02-04-2010 |
| 20110189712 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention. | 08-04-2011 |
| 20110250627 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention. | 10-13-2011 |
| 20130078664 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention. | 03-28-2013 |
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| 20100109747 | Systems and Methods Using Improved Clock Gating Cells - A clock gating cell that comprises a latch in communication with an input enable logic and an output logic circuit, wherein the latch includes a pull-up and/or a pull-down circuit at an input node of the output logic circuit and circuitry preventing premature charge or discharge of the output logic circuit input node by the pull-up and/or the pull-down circuit when the clock gating cell is enabled. | 05-06-2010 |
| 20120210284 | Method and Apparatus for Characterizing and Reducing Proximity Effect on Cell Electrical Characteristics - Circuit elements are characterized for effects of proximity context on electrical characteristic. Based on the characterization, proximity context cell models, and corresponding modeled electrical characteristic values are obtained. Logic cells are characterized and modeled according to the proximity context cell models. Optionally the electrical characteristic can be time delay, leakage, dynamic power, or coupling noise among other parameters. | 08-16-2012 |
| 20130015882 | Compact and Robust Level Shifter Layout DesignAANM Datta; AnimeshAACI San DiegoAAST CAAACO USAAGP Datta; Animesh San Diego CA USAANM Goodall, III; William JamesAACI CaryAAST NCAACO USAAGP Goodall, III; William James Cary NC US - Method and apparatus for voltage level shifters (VLS) design in bulk CMOS technology. A multi-voltage circuit or VLS that operate with different voltage levels and that provides area and power savings for multi-bit implementation of level shifter design. A two-bit VLS to shift bits from a first voltage level logic to a second voltage level logic. The VLS formed with a first N-well in a substrate. The VLS formed with a second N-well in the substrate, adjacent to a side of the first N-well. The VLS formed with a third N-well in the substrate, adjacent to a side of the first N-well and opposite the second N-well. A first one-bit VLS circuit having a portion formed on the first N-well and a portion formed on the second N-well. A second bit VLS circuit having a portion formed on the first N-well and a portion formed on the third N-well. | 01-17-2013 |
| 20140124868 | SHARED-DIFFUSION STANDARD CELL ARCHITECTURE - A semiconductor standard cell includes an N-type diffusion area and a P-type diffusion area, both extending across the cell and also outside of the cell. The cell also includes a conductive gate above each diffusion area to create a semiconductive device. A pair of dummy gates are also above the N-type diffusion area and the P-type diffusion area creating a pair of dummy devices. The pair of dummy gates are disposed at opposite edges of the cell. The cell further includes a first conductive line configured to couple the dummy devices to power for disabling the dummy devices. | 05-08-2014 |
| 20140211893 | HIGH FREQUENCY SYNCHRONIZER - Techniques for resolving a metastable state in a synchronizer are described herein. In one embodiment, a circuit for resolving a metastable state in a synchronizer comprises a signal delay circuit coupled to a node of the synchronizer, wherein the signal delay circuit is configured to delay a data signal at the node to produce a delayed data signal, and a transmission circuit coupled to the signal delay circuit, wherein the transmission circuit is configured to couple the delayed data signal to the node after a delay from a first edge of a clock signal. | 07-31-2014 |
| 20140306735 | FLIP-FLOP WITH REDUCED RETENTION VOLTAGE - A circuit including a logic gate responsive to a clock signal and to a control signal. The circuit also includes a master stage of a flip-flop. The circuit further includes a slave stage of the flip-flop responsive to the master stage. The circuit further includes an inverter responsive to the logic gate and configured to output a delayed version of the clock signal. An output of the logic gate and the delayed version of the clock signal are provided to the master stage and to the slave stage of the flip-flop. The master stage is responsive to the control signal to control the slave stage. | 10-16-2014 |
| 20140330994 | SYNCHRONOUS DATA-LINK THROUGHPUT ENHANCEMENT TECHNIQUE BASED ON DATA SIGNAL DUTY-CYCLE AND PHASE MODULATION/DEMODULATION - A synchronous data-link throughput enhancement technique based on data signal duty-cycle and phase modulation demodulation is disclosed. A method includes receiving multiple bits to be transmitted, encoding the multiple bits to generate a multi-bit signal that represents the multiple bits, and transmitting, via a synchronous interface, the multi-bit signal during a time period that corresponds to one-half of a cycle of a synchronization signal. | 11-06-2014 |
| 20140359385 | CIRCUIT AND LAYOUT TECHNIQUES FOR FLOP TRAY AREA AND POWER OTIMIZATION - Techniques for reducing scan overhead in a scannable flop tray are described herein. In one embodiment, a scan circuit for a flop tray comprises a tri-state circuit configured to invert an input data signal and output the inverted data signal to an input of a flip-flop of the flop tray in a normal mode, and to block the data signal from the input of the flip-flop in a scan mode. The scan circuit also comprises a pass gate configured to pass a scan signal to the input of the flip-flop in the scan mode, and to block the scan signal from the input of the flip-flop in the normal mode. | 12-04-2014 |
| 20140368247 | NOVEL LOW OVERHEAD HOLD-VIOLATION FIXING SOLUTION USING METAL-PROGRAMABLE CELLS - Techniques for fixing hold violations using metal-programmable cells are described herein. In one embodiment, a system comprises a first flip-flop, a second flip-flop, and a data path between the first and second flip-flops. The system further comprises a metal-programmable cell connected to the data path, wherein the metal-programmable cell is programmed to implement at least one capacitor to add a capacitive load to the data path. The capacitive load adds delay to the data path that prevents a hold violation at one of the first and second flip-flops. | 12-18-2014 |
| 20150054567 | LAYOUT CONSTRUCTION FOR ADDRESSING ELECTROMIGRATION - A first interconnect on an interconnect level connects a first subset of PMOS drains together of a CMOS device. A second interconnect on the interconnect level connects a second subset of the PMOS drains together. The second subset of the PMOS drains is different than the first subset of the PMOS drains. The first interconnect and the second interconnect are disconnected on the interconnect level. A third interconnect on the interconnect level connects a first subset of NMOS drains together of the CMOS device. A fourth interconnect on the interconnect level connects a second subset of the NMOS drains together. The second subset of the NMOS drains is different than the first subset of the NMOS drains. The third interconnect and the fourth interconnect are disconnected on the interconnect level. The first, second, third, and fourth interconnects are coupled together though at least one other interconnect level. | 02-26-2015 |
| 20150054568 | LAYOUT CONSTRUCTION FOR ADDRESSING ELECTROMIGRATION - A CMOS device with a plurality of PMOS transistors each having a PMOS drain and a plurality of NMOS transistors each having an NMOS drain includes a first interconnect on an interconnect level extending in a length direction to connect the PMOS drains together. A second interconnect on the interconnect level extends in the length direction to connect the NMOS drains together. A set of interconnects on at least one additional interconnect level couple the first interconnect and the second interconnect together. A third interconnect on the interconnect level extends perpendicular to the length direction and is offset from the set of interconnects to connect the first interconnect and the second interconnect together. | 02-26-2015 |
| 20150221639 | DIGITAL CIRCUIT DESIGN WITH SEMI-CONTINUOUS DIFFUSION STANDARD CELL - A CMOS device including a standard cell includes first and second transistors with a gate between the first and second transistors. One active region extends between the first and second transistors and under the gate. In a first configuration, when drains/sources of the first and second transistors on the sides of the gate carry the same signal, the drains/sources are connected together and to the gate. In a second configuration, when a source of the first transistor on a side of the gate is connected to a source voltage and a drain/source of the second transistor on the other side of the gate carries a signal, the source of the first transistor is connected to the gate. In a third configuration, when sources of the first and second transistors on the sides of the gate are connected to a source voltage, the gate floats. | 08-06-2015 |
| 20150249076 | HIGH PERFORMANCE STANDARD CELL - A transistor cell is provided that includes a dummy gate overlaying a continuous oxide definition (OD) region. A first portion of the OD region adjacent a first side of the dummy forms the drain. The cell includes a local interconnect structure that couples the dummy gate and a portion of the OD region adjacent a second opposing side of the dummy gate to a source voltage. | 09-03-2015 |
| 20160124043 | CIRCUIT TECHNIQUES FOR EFFICIENT SCAN HOLD PATH DESIGN - In one embodiment, a method for signal delay in a scan path comprises, in a scan mode, delaying a scan signal in the scan path by propagating the scan signal through a plurality of delay devices coupled in series, wherein a first one of the delay devices is powered by a first voltage, a second one of the delay devices is powered by a second voltage, and the second voltage is greater than the first voltage. The method also comprises, in a functional mode, disabling the delay devices. | 05-05-2016 |
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| 20090010966 | MODIFIED DIPHTHERIA TOXINS - The present application relates to compositions of modified diphtheria toxin and fusion proteins containing modified diphtheria toxin that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome, as well as methods of making the compositions. The present application also relates to a polypeptide toxophore from a modified diphtheria toxin, where the modification is at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of an unmodified native diphtheria toxin. Also described are fusion proteins which contain a modified diphtheria toxin and a non-diphtheria toxin fragment which contains a cell binding portion. The modified diphtheria toxins described can be used for the treatment of a malignant disease or a non-malignant disease. | 01-08-2009 |
| 20090041797 | MODIFIED TOXINS - The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease. | 02-12-2009 |
| 20090221500 | MODIFIED TOXINS - The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease. | 09-03-2009 |
| 20100254943 | AMINO ACID SUBSTITUTED MOLECULES - The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein. | 10-07-2010 |
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| 20090318793 | Disposable Patch and Reusable Sensor Assembly for Use in Medical Device Localization and Mapping Systems - An patch and sensor assembly for use in an EP mapping system has two portions: a reusable portion and a disposable portion. The reusable portion houses the biosensors used in magnetic based location and mapping systems and the electrical lead necessary to communicate between the biosensor and the mapping system. The reusable portion may also contain a portion of the electrode necessary to receive electrical signals from the body of the patient. The disposable portion of the patch and sensor assembly contains an adhesive covered flexible patch having at least a portion of the electrode used to receive electrical signals form the body of the patient and may contain the electrical lead necessary to communicate such an electrical signal to the mapping system. The disposable portion contains a receptacle adapted to receive and mechanically secure the reusable portion to the disposable portion of the assembly. Such a patch and sensor assembly is useful in hybrid magnetic and impedance based location and mapping systems such as those used in electrophysiology. | 12-24-2009 |
| 20090318796 | Patch and sensor assembly for use in medical device localization and mapping systems - An patch and sensor assembly for use in an EP mapping system has two portions: a reusable portion and a disposable portion. The reusable portion houses the biosensors used in magnetic based location and mapping systems and the electrical lead necessary to communicate between the biosensor and the mapping system. The reusable portion may also contain a portion of the electrode necessary to receive electrical signals from the body of the patient. The disposable portion of the patch and sensor assembly contains an adhesive covered flexible patch having at least a portion of the electrode used to receive electrical signals form the body of the patient and may contain the electrical lead necessary to communicate such an electrical signal to the mapping system. The disposable portion contains a receptacle adapted to receive and mechanically secure the reusable portion to the disposable portion of the assembly. Such a patch and sensor assembly is useful in hybrid magnetic and impedance based location and mapping systems such as those used in electrophysiology. | 12-24-2009 |
| 20100168676 | CATHETER WITH PROTECTIVE BARRIER MEMBER - A device that shields internal organs and tissues from medical procedures performed within a patient's body, especially in the chest cavity where ablation and related procedures are performed in or near the heart, includes a catheter body, a distal section, and a barrier member that can be inflated with fluid to act as a barrier to extreme temperatures and physical trauma, and be deflated to a smaller size to facilitate entry and removal from the patient's chest cavity. In a more detailed embodiment, the barrier member is a balloon that can protects the esophagus, which can be provided with folds and shape memory elements so that the balloon expands and collapses into predetermined configurations. Fluid is fed to and drawn from the barrier member via an irrigation tubing that extends along a catheter shaft and is in communication with a lumen of a deflectable tubing section that extends through an interior cavity of the barrier member. The catheter can be adapted for uni- or bi-directional deflection. | 07-01-2010 |
| 20120165644 | SINGLE RADIO-TRANSPARENT CONNECTOR FOR MULTI-FUNCTIONAL REFERENCE PATCH - A patch and sensor assembly has a magnetic-based biosensor is housed in a reusable portion that connects to the mapping and localization system via biosensor wires, and a disposable portion provides an electrode layer through which impedance-based signals are transmitted to the mapping and localization system via ACL wires, wherein the biosensor wires and the ACL wires extend through a single cable exiting the reusable portion. In one embodiment, the disposable portion includes an adhesive layer for adhering the electrode layer to a patient's body where the electrode layer is disposed on the adhesive hydrogel layer. The disposable portion also includes a foam layer disposed on the electrode layer, and an engagement element adapted to detachably receive at least a portion of a housing of the resuable portion. In one embodiment, the reusable portion includes a housing defining a sealed interior volume in which a magnetic-based biosensor is provided with biosensor wires that exit the reusable portion. The housing is also adapted to carry and/or provide support to an ACL contact member that is responsive to the electrode layer of the disposable portion, and ACL wires for the ACL contact member that exit the reusable portion. Advantageously, the biosensor wires and the ACL wires extend through a single cable to a mapping and localization system. | 06-28-2012 |
| 20130172813 | MEDICAL DEVICE CONTROL HANDLE WITH MULTIPLE PULLER WIRES - A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. | 07-04-2013 |
| 20130211399 | ELECTROPHYSIOLOGY CATHETER WITH MECHANICAL USE LIMITER - A catheter for the treatment of tissue, particularly for the treatment of cardiac tissue to alleviate cardiac arrhythmias includes a connector having mechanical use limiter that may be placed in the handle of the catheter or at any point along the electrical connection pathway to an electro-anatomic mapping system and/or ablation system. The mechanical use limiter has a counter wheel and locking pin which when engaged disables the reconnection of the connector to any mated connector after a predetermined number of uses. | 08-15-2013 |
| 20130231657 | CATHETER FOR TREATMENT OF ATRIAL FLUTTER HAVING SINGLE ACTION DUAL DEFLECTION MECHANISM - A catheter and method for the treatment of a patient having atrial flutter or other arrhythmia comprises an elongated catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. Further it has a distal tip section comprising a flexible tubing having a proximal end and a distal end and a plurality of lumens extending therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The tip section further comprises a nitinol tube having slots formed therein which causes the distal tip section to deflect using the same puller-wire action used to cause the deflectable catheter to deflect at a point proximal to the distal tip section. | 09-05-2013 |
| 20130296729 | CATHETER HAVING TWO-PIECE CONNECTOR FOR A SPLIT HANDLE ASSEMBLY - A catheter and method for the treatment of a patient having atrial flutter or other arrhythmia comprises an elongated catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. Further it has a distal tip section comprising a flexible tubing having a proximal end and a distal end and a plurality of lumens extending therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The tip section further comprises a nitinol tube having slots formed therein which causes the distal tip section to deflect using the same puller-wire action used to cause the deflectable catheter to deflect at a point proximal to the distal tip section. | 11-07-2013 |
| 20160038718 | MEDICAL DEVICE CONTROL HANDLE WITH MULTIPLE PULLER WIRES - A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. | 02-11-2016 |
| 20160045711 | MEDICAL DEVICE CONTROL HANDLE WITH MULTIPLE PULLER WIRES - A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. | 02-18-2016 |
| 20160100885 | CATHETER FOR TREATMENT OF ATRIAL FLUTTER HAVING SINGLE ACTION DUAL DEFLECTION MECHANISM - A catheter and method for the treatment of a patient having atrial flutter or other arrhythmia comprises an elongated catheter body having an outer wall, proximal and distal ends, and at least one lumen extending therethrough. Further it has a distal tip section comprising a flexible tubing having a proximal end and a distal end and a plurality of lumens extending therethrough. The proximal end of the tip section is fixedly attached to the distal end of the catheter body. The tip section further comprises a nitinol tube having slots formed therein which causes the distal tip section to deflect using the same puller-wire action used to cause the deflectable catheter to deflect at a point proximal to the distal tip section. | 04-14-2016 |
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| 20090088697 | CONTROL HANDLE WITH DEVICE ADVANCING MECHANISM - A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device. The device may be a stiffener wire, a needle or any other device suitable for advancement and retraction in a catheter. | 04-02-2009 |
| 20090281453 | MRI Biopsy Apparatus Incorporating a Sleeve and Multi-Function Obturator - A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument, and in particular a sleeve, to a biopsy site of suspicious tissues or lesions. A depth stop enhances accurate insertion, and prevents over-insertion or inadvertent retraction of the sleeve. The sleeve receives a probe of the MRI-compatible biopsy instrument and may contain various features to enhance its imageability, to enhance vacuum and pressure assist therethrough, and marker deployment etc. | 11-12-2009 |
| 20110184385 | CONTROL HANDLE WITH DEVICE ADVANCING MECHANISM - A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device. The device may be a stiffener wire, a needle or any other device suitable for advancement and retraction in a catheter. | 07-28-2011 |
| 20130231586 | MRI BIOPSY APPARATUS INCORPORATING A SLEEVE AND MULTI-FUNCTION OBTURATOR - An apparatus for use with a minimally invasive medical procedure into human breast tissue includes a cannula and an obturator. The cannula includes an open distal end, a lateral opening proximate to the open distal end, and a longitudinal lumen communicating with the lateral opening and the open distal end. The lumen has a non-circular cross-section. The obturator is sized for insertion into the cannula. The obturator has a distal end extending from the open distal end of the cannula when the obturator is inserted fully into the cannula. The obturator has a recess proximate of the distal end of the obturator. The recess is positioned along a portion of the length of the obturator to align with the lateral opening of the cannula when the obturator is inserted fully into the cannula. | 09-05-2013 |
| 20140107582 | CONTROL HANDLE WITH DEVICE ADVANCING MECHANISM - A catheter having an internal advancing mechanism that can advance stiffening wires or other devices, has a catheter with a catheter body, a tip section distal the catheter body, a device extending through at least the catheter body, and a control handle proximal the catheter body, where the control handle has an advancing mechanism with a threaded member, an adjustment member, and a guided member to which the device is connected, and the advancing mechanism is configured to advance and retract the device along the catheter body as controlled by a user. Each of the threaded member and the adjustment member has a generally cylindrical configuration. The threaded member has an outer surface configured with a helical guide channel. The adjustment member is configured to guide the guided member to move within the helical guide channel to advance and retract the device. The adjustment member can be rotatable over the threaded member by the user to control advancement and retraction of the device. The device may be a stiffener wire, a needle or any other device suitable for advancement and retraction in a catheter. | 04-17-2014 |
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| 20080210405 | Fabrication of high surface to volume ratio structures and their integration in microheat exchangers for liquid cooling systems - An structure and method of manufacturing a microstructure for use in a heat exchanger is disclosed. The heat exchanger comprises a manifold layer and an microstructured region. The manifold layer comprises a structure to deliver fluid to the microstructured region. The microstructured region is formed from multiple windowed layers formed from heat conductive layers through which a plurality of microscaled apertures have been formed by a wet etching process. The plurality of windowed layers are then coupled together to form a composite microstructure. | 09-04-2008 |
| 20100032143 | MICROHEAT EXCHANGER FOR LASER DIODE COOLING - A microheat exchanging assembly is configured to cool one or more heat generating devices, such as integrated circuits or laser diodes. The microheat exchanging assembly includes a first ceramic assembly thermally coupled to a first surface, and in cases, a second ceramic assembly thermally coupled to a second surface. The ceramic assembly includes one or more electrically and thermally conductive pads to be thermally coupled to a heat generating device, each conductive pad is electrically isolated from each other. The ceramic assembly includes a ceramic layer to provide this electrical isolation. A top surface and a bottom surface of the ceramic layer are each bonded to a conductive layer, such as copper, using an intermediate joining material. A brazing process is performed to bond the ceramic layer to the conductive layer via a joining layer. The joining layer is a composite of the joining material, the ceramic layer, and the conductive layer. | 02-11-2010 |
| 20100035024 | BONDED METAL AND CERAMIC PLATES FOR THERMAL MANAGEMENT OF OPTICAL AND ELECTRONIC DEVICES - A ceramic assembly includes one or more electrically and thermally conductive pads to be thermally coupled to a heat generating device, each conductive pad is electrically isolated from each other. The ceramic assembly includes a ceramic layer to provide this electrical isolation. The ceramic layer has high thermal conductivity and high electrical resistivity. A top surface and a bottom surface of the ceramic layer are each bonded to a conductive layer, such as copper, using an intermediate joining material. A brazing process is performed to bond the ceramic layer to the conductive layer via a joining layer. The joining layer is a composite of the joining material, the ceramic layer, and the conductive layer. The top conductive layer and the joining layer are etched to form the electrically isolated conductive pads. The conductive layers are bonded to the ceramic layer using a bare ceramic approach or a metallized ceramic approach. | 02-11-2010 |
| 20110073292 | FABRICATION OF HIGH SURFACE AREA, HIGH ASPECT RATIO MINI-CHANNELS AND THEIR APPLICATION IN LIQUID COOLING SYSTEMS - The present invention provides methods and apparatuses which achieve high heat transfer in a fluid cooling system, and which do so with a small pressure drop across the system. The present invention teaches the use of wall features on the fins of a heat exchanger to cool fluid in a fluid cooling system. The present invention also discloses high aspect ratio, high surface area structures applicable in micro-heat exchangers for fluid cooling systems and cost effective methods for manufacturing the same. | 03-31-2011 |
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| 20130339281 | MULTI-PROCESSOR CORTICAL SIMULATIONS WITH RECIPROCAL CONNECTIONS WITH SHARED WEIGHTS - Embodiments of the invention relate to distributed simulation frameworks that provide reciprocal communication. One embodiment comprises interconnecting neuron groups on different processors via a plurality of reciprocal communication pathways, and facilitating the exchange of reciprocal spiking communication between two different processors using at least one Ineuron module. Each processor includes at least one neuron group. Each neuron group includes at least one electronic neuron. | 12-19-2013 |
| 20140180988 | HARDWARE ARCHITECTURE FOR SIMULATING A NEURAL NETWORK OF NEURONS - Embodiments of the invention relate to a neural network system for simulating neurons of a neural model. One embodiment comprises a memory device that maintains neuronal states for multiple neurons, a lookup table that maintains state transition information for multiple neuronal states, and a controller unit that manages the memory device. The controller unit updates a neuronal state for each neuron based on incoming spike events targeting said neuron and state transition information corresponding to said neuronal state. | 06-26-2014 |
| 20150227558 | MAPPING NEURAL DYNAMICS OF A NEURAL MODEL ON TO A COARSELY GRAINED LOOK-UP TABLE - Embodiments of the invention relate to mapping neural dynamics of a neural model on to a lookup table. One embodiment comprises defining a phase plane for a neural model. The phase plane represents neural dynamics of the neural model. The phase plane is coarsely sampled to obtain state transition information for multiple neuronal states. The state transition information is mapped on to a lookup table. | 08-13-2015 |
| 20150347870 | SCENE UNDERSTANDING USING A NEUROSYNAPTIC SYSTEM - Embodiments of the invention provide a method for scene understanding based on a sequence of image frames. The method comprises converting each pixel of each image frame to neural spikes, and extracting features from the sequence of image frames by processing neural spikes corresponding to pixels of the sequence of image frames. The method further comprises encoding the extracted features as neural spikes, and classifying the extracted features. | 12-03-2015 |
| 20160034808 | HARDWARE ARCHITECTURE FOR SIMULATING A NEURAL NETWORK OF NEURONS - Embodiments of the invention relate to a neural network system for simulating neurons of a neural model. One embodiment comprises a memory device that maintains neuronal states for multiple neurons, a lookup table that maintains state transition information for multiple neuronal states, and a controller unit that manages the memory device. The controller unit updates a neuronal state for each neuron based on incoming spike events targeting said neuron and state transition information corresponding to said neuronal state. | 02-04-2016 |
| 20160125289 | MAPPING GRAPHS ONTO CORE-BASED NEUROMORPHIC ARCHITECTURES - Embodiments of the invention provide a method for mapping a bipartite graph onto a neuromorphic architecture comprising of a plurality of interconnected neuromorphic core circuits. The graph includes a set of source nodes and a set of target nodes. The method comprises, for each source node, creating a corresponding splitter construct configured to duplicate input. Each splitter construct comprises a first portion of a core circuit. The method further comprises, for each target node, creating a corresponding merger construct configured to combine input. Each merger construct comprises a second portion of a core circuit. Source nodes and target nodes are connected based on a permutation of an interconnect network interconnecting the core circuits. | 05-05-2016 |
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| 20120130288 | ULTRASOUND-MEDIATED INDUCEMENT, DETECTION, AND ENHANCEMENT OF STABLE CAVITATION - Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy. | 05-24-2012 |
| 20130144161 | Flow Quantification in Ultrasound Using Conditional Random Fields with Global Consistency - Velocities are unaliased using conditional random fields. To constrain the energy minimization function, a global term includes a measure of a level of aliasing. In one example, the measure of the level of aliasing is based on a change in volume, such as the volume of the left ventricle. The unaliasing is performed along one or more surfaces, such as surfaces intersecting the mitral annulus and the left ventricle outflow tract. The anatomy used is identified and/or tracked using one or more machine-learnt detectors. Both B-mode and velocity information may be used for detecting the anatomy. | 06-06-2013 |
| 20140052001 | Mitral Valve Detection for Transthoracic Echocardiography - A mitral valve is detected in transthoracic echocardiography. The ultrasound transducer is positioned against the chest of the patient rather than being inserted within the patient. While data acquired from such scanning may be noisier or have less resolution, the mitral valve may still be automatically detected. Using both B-mode data representing tissue as well as flow data representing the regurgitant jet, the mitral valve may be detected automatically with a machine-learnt classifier. A series of classifiers may be used, such as determining a position and orientation of a valve region with one classifier, determining a regurgitant orifice with another classifier, and locating mitral valve anatomy with a third classifier. One or more features for some of the classifiers may be calculated based on the orientation of the valve region. | 02-20-2014 |
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| 20110144495 | Perfusion Imaging of a Volume in Medical Diagnostic Ultrasound - A volume is scanned with ultrasound for determining perfusion. A volume is scanned with a more rapid technique for tracking a sub-volume, and the tracked sub-volume is scanned for contrast agent detection with a less rapid technique. For example, a single pulse technique or B-mode scanning is used to track a region over one or more cycles, the location of the tracked region is predicted, and multiple pulse contrast agent detection is performed for the sub-volume at the predicted location. The combinations of scanning provide for real-time or higher temporal resolution reperfusion information at the appropriate tissue. Using a separate scan for motion tracking may provide a more robust prediction of the sub-volume location and a better visualization of the results (e.g., orientation within the organ). In other embodiments, tracking is based on a B mode image derived from the multi-pulse data. | 06-16-2011 |
| 20110208056 | Volumetric Quantification for Ultrasound Diagnostic Imaging - Volumetric quantification is provided in medical diagnostic ultrasound. By acquiring both B-mode and color flow data without stitching or acquiring in real-time at tens of volumes a second, more reliable quantification may be provided. Using multiple regions of interest in a volume may allow for more accurate and/or complete flow information, such as averaging flow from different locations in the same structure (e.g., use preservation of mass to acquire multiple measures of the same flow). | 08-25-2011 |
| 20110218435 | Prediction-Based Flow Estimation for Ultrasound Diagnostic Imaging - Flow estimation is provided. The flow is predicted. A mathematical, logic, machine learning or other model is used to predict flow. For example, the boundary conditions associated with a previous flow, the previous flow, and current boundary conditions are used to predict the current flow. The current flow is corrected using the predicted flow. Velocities may be unaliased based on the predicted flow. The predicted flow may replace the current flow. Prediction may additionally or alternatively be used in determination of lateral or elevational flow. | 09-08-2011 |
| 20110301466 | CARDIAC FLOW QUANTIFICATION WITH VOLUMETRIC IMAGING DATA - A method quantifies cardiac volume flow for an imaging sequence. The method includes receiving data representing three-dimensions and color Doppler flow data over a plurality of frames, constructing a ventricular model based on the data representing three-dimensions for the plurality of frames, the ventricular model including a sampling plane configured to measure the cardiac volume flow, computing volume flow samples based on the sampling plane and the color Doppler flow data, and correcting the volume flow samples for aliasing based on volumetric change in the ventricular model between successive frames of the plurality of frames. | 12-08-2011 |
| 20120215110 | Multiple Beam Spectral Doppler in Medical Diagnostic Ultrasound Imaging - Spatially distinct Spectral Doppler information is acquired. Spatially distinct transmit beams are formed at a same time or in parallel. One or more receive beams are formed in response to each transmit beam, providing samples for a plurality of laterally spaced locations. A spectrum is determined for each of a plurality of spatial locations. In another approach, samples are acquired for different regions at different times. The scanning for each region is interleaved based on the anatomic operation. Since spectral estimation relies on a time-continuous series of transmission and reception, the scanning for a region occurs over a sufficient period for spectral estimation before the scanning for a different region occurs. By using anatomic operation, sufficient time is provided for spectral estimation. Due to anatomic operation, different regions are associated with flow at different times. | 08-23-2012 |
| 20130245441 | Pressure-Volume with Medical Diagnostic Ultrasound Imaging - Pressure-volume analysis is provided in medical diagnostic ultrasound imaging. The heart of a patient is scanned multiple times during a given cycle. B-mode and flow information are obtained for various times. The flow information is used to estimate pressure over time. A reference pressure, such as from a cuff, may be used to calibrate the pressure waveform. The B-mode information is used to determine a heart volume over time, such as a left ventricle volume over time. The heart volume over time and pressure over time are plotted, providing a pressure-volume loop. The pressure-volume loop is determined non-invasively with ultrasound. | 09-19-2013 |
