Croce, US
Carlo Croce, Philadelphia, PA US
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20090123533 | Compositions and methods for cancer diagnosis and therapy - The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit the neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases. | 05-14-2009 |
20100173319 | COMPOSITIONS AND METHODS FOR CANCER DIAGNOSIS AND THERAPY - The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or miR16 gene copy number, by determining miR15 or miR16 gene mutational status, or by detecting a reduction in the RNA transcribed from these genes. The miR15 or miR16 gene products can inhibit the neoplastic or tumorigenic growth of cancers such as chronic lymphocytic leukemia or prostate cancer cells when administered to subjects suffering from these diseases. | 07-08-2010 |
Carlo Croce, Columbus, OH US
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20110086348 | METHOD FOR ASSESSING HEART DISEASE - A method for assessing heart disease in a subject includes generating an expression profile of at least two or more miRNAs in a sample from the subject. The miRNAs can be selected from the group consisting of hsa-miRNA-1, hsa-miRNA-7, hsa-miRNA-29b, has-miRNA-125b, hsa-miRNA145, hsa-miRNA-181b, hsa-miRNA-214, hsa-miRNA-342, hsa-miRNA-378 and combinations thereof. | 04-14-2011 |
Carlo M. Croce, Philadelphia, PA US
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20080256650 | Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression - Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals provide a useful animal model system for human B cell chronic lymphocytic leukemia. | 10-16-2008 |
20100192235 | HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA MODELED IN MOUSE BY TARGETED TCL1 EXPRESSION - Transgenic animals containing a nucleic acid sequence encoding TCL1 operably linked to transcriptional control sequences directing expression to B cells are described. Such transgenic animals provide a useful animal model system for human B cell chronic lymphocytic leukemia. | 07-29-2010 |
20100285480 | TCL-1 GENE AND PROTEIN AND RELATED METHODS AND COMPOSITIONS - The present invention relates to nucleotide sequences of TCL-1 genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The TCL-1 gene sequence is preferentially expressed early in T and B lymphocyte differentiation. The present invention further relates to the use of TCL-1 genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with chromosomal abnormalities. | 11-11-2010 |
Carlo M. Croce, Columbu, OH US
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20110179501 | Methods for Reverting Methylation by Targeting DNMT3A and DNMT3B - Methods for restoring a desired pattern of DNA methylation, inducing re-expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed. | 07-21-2011 |
Carlo Maria Croce, Columbus, OH US
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20100184032 | Stem-Progenitor Cell Specific Micro-Ribonucleic Acids and Uses Thereof - Provided herein are methods and compositions for modulating the differentiation of incompletely differentiated cells, such as stem-progenitor cells, e.g., hematopoietic stem-progenitor cells. A method may comprise contacting a cell with an agononist or an antagonist of a miRNA comprising a nucleotide sequence from SEQ ID NO: 1-34. | 07-22-2010 |
Gary Croce, Cherry Hill, NJ US
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20120023755 | MULTIPURPOSE GARDEN TOOL - A tool for removing unwanted plants from an area of soil is disclosed. A flexible two-edged blade bent back upon itself with both ends fastened to a common shaft. One edge acts as a knife to slice through soil and roots, moving parallel to the surface of the ground. The opposing blade edge has teeth to grasp, uproot and remove unwanted plants. The design facilitates the removal of unwanted plants or debris without touching said debris with the hands. | 02-02-2012 |
James Anthony Croce, Coats, NC US
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20130294739 | Cable Anchoring System for a Fiber Optic Enclosure - A cable sealing and cable anchoring system having a primary sealant assembly that includes a primary volume of sealant that defines a plurality of primary through-ports. The primary sealant assembly includes a primary actuator for pressurizing the primary volume of sealant. The cable sealing and cable anchoring system also has a secondary cable tube that mounts within one of the primary cable through-ports and a secondary cable sealant assembly that mounts within a first end of the secondary cable tube. The secondary cable sealant assembly includes a secondary sealant volume that defines a plurality of secondary cable through-ports. The secondary cable sealant assembly also includes a secondary actuator for pressurizing the secondary sealant volume. The cable sealing and cable anchoring system further has a cable anchoring assembly for anchoring a strength member of a secondary cable to the secondary cable tube. The cable anchoring assembly is supported by the secondary cable tube adjacent the second end of the secondary cable tube. | 11-07-2013 |
Kevin Croce, West Roxbury, MA US
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20150315577 | A METHOD FOR INHIBITING CALCIFICATION OF A MACROPHAGE-DERIVED MATRIX VESICLE - The invention relates to methods for decreasing, inhibiting, preventing, or reducing matrix vesicle induced calcification by inhibiting the amount or formation of a complex comprising phosphatidylserine (PS), annexin II, annexin V or VI, and S100A9 or S100A12 in a macrophage. | 11-05-2015 |
Kimiko Della Croce, Tucson, AZ US
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20090099165 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 04-16-2009 |
20090143399 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 06-04-2009 |
20110212929 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 09-01-2011 |
Nicholas C. Croce, Old Brookville, NY US
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20090019048 | Document lock manager - A lock manager is provided for locking documents. In some implementations, the lock manger initiates a first lock on a document that prevents other users from editing the document while it is being displayed to the user. If edits to the document are made by the user, the edits are placed in a queue for subsequent finalization, and a second lock is placed on the document. The second lock prevents other users from editing the document until the edits have been finalized. | 01-15-2009 |
20090019379 | Document Redaction in a Web-Based Data Analysis and Document Review System - A web-based data analysis and document review system is operable to provide a graphical user interface that allows a user to make and save redactions within a selected document set, apply the redactions to other document sets, clear redactions on a particular page of a document, and clear all redactions within the document. | 01-15-2009 |
20090024942 | Document Printing for a Web-Based Data Analysis and Document Review System - A web-based data analysis and document review system is operable to provide a graphical user interface that allows a user to select print options for a group of documents stored by the system. The print options include different print formats each of which offers the user a respective set of features which can be selected for printing the particular group of documents as part of a batch print job. | 01-22-2009 |
Scott Croce, E. Brunswick, NJ US
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20110081201 | Reflective roadway warning system indicating incorrect vehicular travel direction - A plurality of reflector devices each having a reflective element, the reflector devices embeddable in the roadway of an off ramp, or in the curbing of an off ramp, and/or in the guardrails adjacent an off ramp or other one way street, the reflector warning system providing a visible alarm or alert to a driver in day or night conditions or low visibility that the driver has mistakenly or inadvertently turned his vehicle onto and is proceeding up an off ramp or other road way to another intersecting highway, and as such will encounter oncoming opposing traffic such that the driver can stop, reverse, and correct the mistake. The reflector devices embedded in the roadway depending upon their spacing will also provide a significantly tactile feedback to the driver that he is proceeding in the wrong direction by causing a vibration to the tires which is transmittable to the steering wheel. | 04-07-2011 |
Teresa A. Croce, Nashville, TN US
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20090306335 | MULTIFUNCTIONAL DEGRADABLE NANOPARTICLES WITH CONTROL OVER SIZE AND FUNCTIONALITIES - In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-10-2009 |
20110257343 | Multifunctional Degradable Nanoparticles with Control over Size and Functionalities - In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-20-2011 |