Coussens
Anna Kathleen Coussens, Clearview AU
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20100330085 | METHOD OF TREATMENT, PROPHYLAXIS AND DIAGNOSIS OF PATHOLOGIES OF THE BONE - The present invention relates generally to the fields of treatment, prophylaxis and diagnosis. More particularly, the present invention identifies genes and gene products associated with bone morphogenesis and pathologies of the bone. Even more particularly, the present invention contemplates the regulation of expression of these genes or the activity of the gene products in the treatment, prophylaxis and diagnosis of bone pathologies. Cell-based therapies and manipulation of cells in in vitro culture also form part of the present invention. | 12-30-2010 |
Betty Bernice Coussens, Houthalen BE
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20110136186 | PREPARATION OF ALPHA-AMINO-EPSILON-CAPROLACTAM VIA LYSINE CYCLISATION - The present invention relates to a method for preparing α-amino-ε-caprolactam, comprising converting lysine to α-amino-ε-caprolactam, wherein the conversion is catalysed by a biocatalyst. Further, the invention relates to a host cell comprising at least one recombinant vector comprising a nucleic acid sequence encoding a biocatalyst with lysine cyclase activity. Further a method is provided wherein α-amino-ε-caprolactam is used for preparing c-caprolactam. | 06-09-2011 |
Lisa M. Coussens, Corte Madera, CA US
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20080206219 | Novel Indications for Transforming Growth Factor-Beta Regulators - Methods, compounds and compositions for the modulation of TGF-β are disclosed wherein the vascular permeability in a subject is altered. The compounds can be antagonists or agonists, and can be oligonucleotides, antisense oligonucleotides, small molecules, antibodies, and the like. Compounds that modulate TGF-β, regulate TGF-β bioavailabililty, or the configuration and context of type 1 collagen can be used for the treatment or prevention of diseases caused by vascular permeability. | 08-28-2008 |
20120329878 | PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES - The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient. | 12-27-2012 |
Lisa M. Coussens, Lake Oswego, OR US
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20140100188 | PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES - The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient. | 04-10-2014 |
Paul M. Coussens, Floshing, MI US
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20090263406 | JY-1 Regulation Of Granulosa Cell Function And Early Embryonic Development In Cattle - The present invention provides compositions and methods for regulating fertility in mammals. In general, the invention relates to a novel protein produced by oocytes named JY-1, and nucleic acids encoding the JY-1 protein, for controlling folliculogenesis and early embryonic development, particularly in monoovulatory species. In particular, the present invention provides nucleic acid and amino acid sequences encoding JY-1, vectors for the expression of JY-1, host cells expressing JY-1, RNAi probes for reducing levels of JY-1 message, and antibodies to JY-1. Specifically, developing and mature oocytes express JY-1 in vivo, while granulosa cells treated in vitro with recombinant JY-1 (rJY-1) protein reduced cell proliferation while increasing progesterone synthesis and estradiol production. Further, reducing JY-1 protein in developing embryos in vitro using inhibitory siRNA constructs corresponded with arrested blastocyte maturation. | 10-22-2009 |
Paul Michael Coussens, Belaire, MI US
Patent application number | Description | Published |
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20110182931 | IMMORTAL AVIAN CELL LINE AND METHODS OF USE - A avian cell line that supports replication of animal or human viruses, which cell line is adapted to animal-product free growth. The cell line is useful for propagating a virus suitable as a live or a killed vaccine and for virus isolation and diagnostic assays. | 07-28-2011 |