Costantino
Francesca Costantino, Milano IT
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20080207575 | Process For The Preparation Of Drospirenone - A process is described for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action; comprising the oxidation of 17α-(3-hydroxypropyl)-6β,7β,15β,16β-dimethylene-5β-androstane-3β,5,17β-triol. | 08-28-2008 |
20100331291 | PROCESS FOR THE PREPARATION OF DROSPIRENONE - A process is described for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action by the oxidation of 17α-(3-hydroxypropyl)-6β,7β,15β, 16β-dimethylene-5β-androstane-3β,5,17β-triol. | 12-30-2010 |
20120264723 | PROCESS FOR THE PREPARATION OF DROSPIRENONE - A process is described for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action; comprising the oxidation of 17α-(3-hydroxypropyl)-6β,7β,15β,16β-dimethylene-5β-androstane-3β,5,17β-triol. | 10-18-2012 |
Gabriele Costantino, Medesano IT
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20130289081 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE - A derivative of nicotinic acid N-oxide is described having formula (I): that acts as inhibitor of enzyme 3-hydroxyanthranilate-3,4-dioxygenase (3HAO), and is thus able to reduce QUIN biosynthesis in vivo under excitotoxic or pathological conditions, said compound being at the same time also chemically stable towards auto-oxidation. | 10-31-2013 |
Leandro L. Costantino, Carlos Paz AR
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20140072235 | INTERACTIVE VISUAL ADVERTISEMENT SERVICE - In accordance with embodiments disclosed herein, there are provided systems, apparatuses, and methods for implementing an interactive visual advertisement service as described herein. For example, in one embodiment, such means may include means for transmitting a message for display on an electronic visual display device in which the message includes a requested action to be performed by a user; means for receiving a sequence of electronic images of a performed action having been performed by the user subsequent to transmitting the message for display; means for evaluating the sequence of electronic images of the performed action by the user to determine whether the performed action by the user substantially matches the requested action of the message; and means for transmitting a notification for display on the electronic visual display device when the performed action by the user substantially matches the requested action of the message. | 03-13-2014 |
Paolo Costantino, Colle Di Val D'Elsa IT
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20150132339 | ADJUVANTED FORMULATIONS OF STREPTOCOCCUS PNEUMONIAE ANTIGENS - The efficacy of | 05-14-2015 |
Paolo Costantino, Colle Val D' Elsa IT
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20120237549 | CONJUGATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR POLYSACCHARIDES - The invention provides a process for preparing a conjugate of a | 09-20-2012 |
20120282295 | PURIFICATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR SACCHARIDES - The invention provides a method for releasing capsular polysaccharide from | 11-08-2012 |
Paolo Costantino, Monteriggioni IT
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20150104479 | MENINGOCOCCUS SEROGROUP X CONJUGATE - The invention provides a conjugate of a | 04-16-2015 |
Paolo Costantino, Colle Val D'Elsa IT
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20100203137 | FORMULATION OF MENINGITIS VACCINES - A liquid Hib component is used to reconstitute a lyophilised meningococcal component, thereby producing a combined meningitis vaccine. A lyophilised meningococcal component can also be reconstituted with an oil-in-water emulsion. | 08-12-2010 |
20100266626 | ADJUVANTED GLUCANS - The use of beta-glucans as antigens for immunising against fungi is known. According to the invention, the beta-glucans are administered together with an adjuvant. The adjuvant improves the immune response. The glucan will usually be conjugated to a carrier. Suitable glucans include laminarin and curdlan. | 10-21-2010 |
20100272755 | FERMENTATION PROCESSES FOR CULTIVATING STREPTOCOCCI AND PURIFICATION PROCESSES FOR OBTAINING CPS THEREFROM - This invention is in the field of bacterial cultures and specifically relates to the optimization of culture conditions to improve the production of bacterial capsular polysaccharides from | 10-28-2010 |
20110045015 | CONJUGATED BETA-1,3-LINKED GLUCANS - Glucans having exclusively or mainly β-1,3 linkages are used as immunogens. These comprise β-1,3-linked glucose residues. Optionally, they may include β-1,6-linked glucose residues, provided that the ratio of β-1,3-linked residues to β-1,6-linked residues is at least 8:1 and/or there are one or more sequences of at least five adjacent non-terminal residues linked to other residues only by β-1,3 linkages. The glucans will usually be used in conjugated form. A preferred glucan source is curdlan, which may be hydrolysed to a suitable form prior to conjugation. | 02-24-2011 |
20110142876 | CONJUGATED VI SACCHARIDES - Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM | 06-16-2011 |
20120308600 | POLYSACCHARIDE IMMUNOGENS CONJUGATED TO E. COLI CARRIER PROTEINS - proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sel1 repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these | 12-06-2012 |
20130142822 | CONJUGATED VI SACCHARIDES - Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM | 06-06-2013 |
20130273091 | IMMUNOGENIC COMPOSITIONS - The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype 1a conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype 1b conjugated to a carrier protein; and c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein. The invention also provides a method for immunising a patient against infection by GBS comprising the step of administering to the patient a conjugate that is a capsular saccharide from GBS conjugated to a diphtheria toxoid or derivative thereof, wherein the patient has been pre-immunised with a diphtheria toxoid or derivative thereof. | 10-17-2013 |
20140011183 | FERMENTATION PROCESSES FOR CULTIVATING STREPTOCOCCI AND PURIFICATION PROCESSES FOR OBTAINING CPS THEREFROM - This invention is in the field of bacterial cultures and specifically relates to the optimization of culture conditions to improve the production of bacterial capsular polysaccharides from | 01-09-2014 |
Santiago Costantino, Montreal CA
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20090173889 | Fluorescent photopolymerizable resins and uses thereof - There is provided fluorescent photopolymerizable resins for use in biological studies and image acquisition. In particular the photopolymerizable resins are useful in studying the properties of cells. The resins are also useful for the calibration of microscopic measurement systems. | 07-09-2009 |
20110204257 | HAEMOZOIN DETECTION - A system for detecting haemozoin in a sample, said system including a light source for exciting the sample with an optical signal to generate a non-linear optical response, and a detector for detecting the generated non-linear optical response from the excited sample. A method for detecting haemozoin in a sample, the method including exciting the sample with an optical signal to generate a non-linear optical response from the sample, and detecting the emitted non-linear optical signal from the excited sample. | 08-25-2011 |
Stephan Costantino, Saint Louis FR
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20120122360 | Method to Produce a Composite Material - Method of producing an elastic composite material comprising the step of impregnating a fiber fabric with a liquid epoxy system comprising a non-aromatic epoxy resin and a hardener, and curing the impregnated fabric, whereby the epoxy system exhibits a tensile modulus lower than 15 MPa after cure. | 05-17-2012 |
20120149266 | Method to Produce a Composite Material - Method of producing an elastic composite material comprising the step of impregnating a fiber fabric with a liquid epoxy system comprising an epoxy resin and a hardener, and curing the impregnated fabric, whereby the epoxy system exhibits a tensile modulus lower than 15 MPa after cure. | 06-14-2012 |
Umberto Costantino, Perugia IT
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20080299202 | Controlled-Delivery System of Pharmacologically Active Substances, Preparation Process and Medical Use Thereof - The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure with a net positive or negative charge able to intercalate (iii) a pharmacologically active principle into said lamellar structure, by establishing an ionic type of bond with it and thereby obtaining an intercalation compound. The preparation process for the release system comprises the stages of: treating the lamellar solid in such a way as to give it a net positive or negative charge, then combining it with the chosen active principle, also in an ionic form, to obtain an intercalation compound which is then mixed with the polymer matrix. The release system can be employed in making medical devices, like sutures, membranes, osteosynthesis plaques, multilayered devices, gels and drug delivery systems. | 12-04-2008 |
Vincenzo Costantino, Bari (ba) IT
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20140309167 | COMBINATION OF ACTIVE INGREDIENTS FOR THE TREATMENT OF ACUTE KIDNEY INJURY - The present invention relates to a new combination for the treatment of renal damage, in particular of acute renal failure and acute kidney injury, the pharmaceutical compositions and the kits containing it and their use in therapy. | 10-16-2014 |