Patent application number | Description | Published |
20090261247 | Linear Ion Trap with Four Planar Electrodes - A rectilinear ion trap includes a first pair of spaced planar RF electrodes, mounted in parallel and a second pair of spaced planar electrodes, mounted in parallel and orthogonal to the first pair of electrodes. The configuration of the pairs of electrodes define an axial direction and a radial direction. The trap further includes an RF source that applies an RF voltage to at least one of the pairs of RF electrodes to generate RF fields to trap ions in the axial and radial directions. | 10-22-2009 |
20100301209 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE - A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure. | 12-02-2010 |
20110042560 | LOW TEMPERATURE PLASMA PROBE AND METHODS OF USE THEREOF - The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow. | 02-24-2011 |
20110240844 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 10-06-2011 |
20120119079 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-17-2012 |
20120295276 | MASS SPECTRAL ANALYSIS - The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. | 11-22-2012 |
20120312979 | ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF - The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member. | 12-13-2012 |
20130105683 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE | 05-02-2013 |
20130112017 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-09-2013 |
20130112866 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-09-2013 |
20130112867 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-09-2013 |
20130126723 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 05-23-2013 |
20130146759 | SYSTEMS AND METHODS FOR SAMPLE ANALYSIS - The invention generally relates to improved sensitivity and flexibility for mass spectrometers with limited pumping capacity, particularly mass spectrometers that are coupled with a Discontinuous Atmospheric Pressure Interface (DAPI). | 06-13-2013 |
20130181010 | SAMPLE DISPENSER INCLUDING AN INTERNAL STANDARD AND METHODS OF USE THEREOF - The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. | 07-18-2013 |
20130273560 | ANALYZING A METABOLITE LEVEL IN A SAMPLE - The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample. | 10-17-2013 |
20130280819 | SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE - The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. | 10-24-2013 |
20130292564 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 11-07-2013 |
20130330714 | MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 12-12-2013 |
20130344610 | SYSTEMS AND METHODS FOR SAMPLE ANALYSIS - The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer. | 12-26-2013 |
20140008529 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 01-09-2014 |
20140008532 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 01-09-2014 |
20140048697 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 02-20-2014 |
20140051180 | SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE - The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. | 02-20-2014 |
20140141466 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 05-22-2014 |
20140158882 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 06-12-2014 |
20140231643 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE - A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure. | 08-21-2014 |
20140264004 | SYSTEMS AND METHODS FOR ANALYZING A SAMPLE USING A MASS SPECTROMETRY PROBE CONFIGURED TO CONTACT THE SAMPLE - The invention generally relates to systems and methods for analyzing a sample using a mass spectrometry probe having a tip that is configured to contact a sample and retain a portion of the sample once the probe has been removed from the sample. | 09-18-2014 |
20140299764 | LOW TEMPERATURE PLASMA PROBE AND METHODS OF USE THEREOF - The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow. | 10-09-2014 |
20150014525 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 01-15-2015 |
20150017712 | MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES - The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. | 01-15-2015 |
20150034818 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE - A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure. | 02-05-2015 |
20150041638 | ION GENERATION USING MODIFIED WETTED POROUS MATERIALS - The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. | 02-12-2015 |
20150075998 | SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS - The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions. | 03-19-2015 |