Patent application number | Description | Published |
20080206207 | Intracoronary Device And Method Of Use Thereof - Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. | 08-28-2008 |
20080287911 | CATHETER WITH LAMINAR FLOW DRUG DELIVERY PROPERTIES - Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed. | 11-20-2008 |
20100047315 | Stent for Increasing Blood Flow to Ischemic Tissues and a Method of Using the Same - Stents and a method of using the stents to increase blood flow to ischemic tissues in a patient are disclosed. | 02-25-2010 |
20100144635 | METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS - Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents. | 06-10-2010 |
20100233263 | METHODS AND COMPOSITIONS FOR TREATMENT OF LESIONED SITES OF BODY VESSELS - Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device. | 09-16-2010 |
20110270225 | METHOD FOR INCREASED UPTAKE OF BENEFICIAL AGENT AND EJECTION FRACTION BY POSTCONDITIONING PROCEDURES - A method for improving tissue uptake of beneficial agent and ejection fraction. | 11-03-2011 |
20110288478 | BALLOON CATHETER EXHIBITING RAPID INFLATION AND DEFLATION - A catheter capable of rapid inflation and deflation and operation by one individual. | 11-24-2011 |
20110319866 | METHODS AND DEVICE FOR SYNERGISTIC MITIGATION OF REPERFUSION INJURY AFTER AN ISCHEMIC EVENT - A method for synergistic mitigation of reperfusion injury after an ischemia event in a subject. | 12-29-2011 |
20120034222 | Nitric Oxide Generating Medical Devices - Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided. | 02-09-2012 |
20120064098 | Intracoronary Device And Method Of Use Thereof - Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. | 03-15-2012 |
20120148609 | INTRACORONARY DEVICE AND METHOD OF USE THEREOF - Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. | 06-14-2012 |
20120148668 | INTRACORONARY DEVICE AND METHOD OF USE THEREOF - Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. | 06-14-2012 |
20120157751 | INTRACORONARY DEVICE AND METHOD OF USE THEREOF - Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems. | 06-21-2012 |
20120219521 | METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS - Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents. | 08-30-2012 |
20130060206 | SPIRAL THROMBECTOMY CATHETER - The subject matter relates a catheter having a helical or spiral tip defining an aspiration port for removing obstructions from blood vessels. | 03-07-2013 |
20130103138 | SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE - Acceleration of the endothelialization process on implantable medical devices having at least one blood-contacting surface is achieved by a microscale pattern of sub-sections of EC-inductive coatings or EC-conductive coatings and nano/macro textured surfaces. The EC-inductive coating and EC-conductive coating can be applied either on the entire surface of the blood-contacting surface or selective placed on the blood-contacting surface, for example, in particular patterns. In this regard, the EC-conductive and EC-inductive coatings can be selectively placed relative to the textured surface to achieve a desired pattern of texture surface to coatings. | 04-25-2013 |
20130165858 | APPARATUS TO PREVENT REPURFUSION INJURY - Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion. | 06-27-2013 |
20130317591 | DRUG ELUTING STENT FOR THE TREATMENT OF DIALYSIS GRAFT STENOSES - A drug-eluting stent having a first cell pattern at one end and a second cell pattern on an opposite end. The cells in the first cell pattern have a smaller MCUSA than those in the second cell pattern. An anti-restonic drug can be coated on the first cell pattern and an anti-thrombotic drug on the second, with the anti-thrombotic drug overlaying and covering both the first and second cell patterns. The stent is operatively positionable at a distal graft-vein anastomosis with the first cell pattern adjacent the stenosis, and with the second cell pattern positioned adjacent the vein or the graft. | 11-28-2013 |
20130344047 | Methods And Composition For Treating Heart Failure And Ischemia - Methods and compositions for treating heart failure by administration of beneficial agents to the heart. | 12-26-2013 |
20140052052 | NEEDLE CATHETER FOR DELIVERY OF AGENTS DIRECTLY INTO VESSEL WALL - A system and method for treating a patient including advancing a catheter into the vasculature of the patient, forcing the catheter to adopt a position in contact with a vessel wall, and causing a needle tip to advance into the wall from a lumen in the catheter external surface that is in contact with the wall. | 02-20-2014 |
20140154300 | METHODS AND COMPOSITIONS FOR TREATMENT OF LESIONED SITES OF BODY VESSELS - Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device. | 06-05-2014 |
20140212355 | TRANS-ARTERIAL DRUG DELIVERY - It is provided herein methods, devices, and compositions for trans-arterial local delivery of therapeutic agent for the treatment of liver cancers. | 07-31-2014 |
20150073535 | Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina - Methods of treating coronary artery disease (CAD) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed. | 03-12-2015 |
Patent application number | Description | Published |
20080300573 | METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY - A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy. | 12-04-2008 |
20090076448 | Methods and devices for eluting agents to a vessel - Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery. | 03-19-2009 |
20090118700 | METHOD FOR TREATING CORONARY VESSELS - A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space. | 05-07-2009 |
20110190698 | Method and Apparatus for Delivering an Agent to a Kidney - Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices. | 08-04-2011 |
20110245766 | Method and Apparatus for Improving Delivery of an Agent to a Kidney - Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members. | 10-06-2011 |
20110262530 | SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I. | 10-27-2011 |
20110263497 | APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I. | 10-27-2011 |
20120108959 | METHODS AND DEVICES FOR ELUTING AGENTS TO A VESSEL - Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery. | 05-03-2012 |
20120203174 | METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY - A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy. | 08-09-2012 |
20120203202 | METHOD AND APPARATUS FOR DELIVERING AN AGENT TO A KIDNEY - A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy. | 08-09-2012 |
20130041453 | Vascular Shield and Delivery System - Devices for providing physical support to vascular regions including vascular regions that may contain an anastomosis region are disclosed. These devices may also deliver therapeutic agents to the vascular region. Methods for using these devices are disclosed, as well. | 02-14-2013 |
20130129814 | Regional Delivery Of Therapeutic Agents For The Treatment Of Vascular Diseases - The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well. | 05-23-2013 |
20130129817 | METHOD OF TREATING MALIGNANT SOLID TUMORS - This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of a drug capable of inhibiting mTOR and/or inhibiting an efflux pump and/or inhibiting HIF-1α and VEGF, the drug in particular being selected from the group consisting of sirolimus, everolimus, zotarolimus, tacrolimus, iolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, novolimus, 40-O-(3-hydroxypropyl), 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin and 40-O-tetrazolylrapamycin, the drug being administered along with a chemotherapeutic agent and/or radiation therapy. | 05-23-2013 |
20130156850 | APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT - A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I. | 06-20-2013 |
20130158509 | SYSTEM, APPARATUS, AND METHOD FOR DENERVATING AN ARTERY - The present disclosed subject matter is directed to a less invasive surgical system, apparatus and method including a guidable catheter for providing electroporation therapy to a subject suffering from heart or kidney disease. The system includes an electrical generator and an apparatus for denervating an artery. The apparatus includes a catheter having a proximal end, a distal end, a first lumen with a first exit port, a second lumen having a second exit port. The apparatus also includes a first needle including a first electrode. The apparatus also includes a displacement mechanism engaged to the catheter near the proximal end such that the displacement mechanism controls the linear position and angular position of the catheter. | 06-20-2013 |
20130224255 | Treatment Of Diabetic Patients With A Drug Eluting Stent And Adjunctive Therapy - Embodiments of the present invention include methods for the treatment, prevention, or amelioration of vascular disease in diabetic patients. The methods include both implantation of a stent including a first drug. Some embodiments include additional therapy, such as the co-administration of another drug. Some embodiments involve different stent selection for a diabetic patient compared to a non-diabetic patient. | 08-29-2013 |
20130261723 | Treatment Of Diabetic Patients With A Drug Eluting Stent And A Drug Coated Balloon - Embodiments of the present invention include methods for the treatment, prevention, or amelioration of vascular disease and/or disorder in diabetic patients. The methods include implantation of a stent including a drug, and the use of a drug coated balloon. The DES may be a DES having a metal body and a coating including the drug, or a bioabsorbable stent with drug in the body of the stent, in a coating on the stent, or both in the body of the stent and in a coating on the stent. | 10-03-2013 |
20130287833 | Nitric Oxide Generating Medical Devices - Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided. | 10-31-2013 |
20140046253 | Methods and Devices for Eluting Agents to a Vessel - Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery. | 02-13-2014 |
20140114401 | Method Of Reducing MACE In Diabetic Patients Subsequent To Stent Placement - This invention relates to the use of dual variable domain antibodies to locate naturally-occurring beneficial agents or therapeutic agents at a region of stent implantation in diabetic patients who have undergone stent implantation. | 04-24-2014 |
20140287033 | LIPID THERAPY - A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation. | 09-25-2014 |
20140364896 | DEVICE, SYSTEM, AND METHOD FOR THROMBUS RETRIEVAL - Implementations of the present invention provide devices, systems, and methods for engaging tissue and/or cells forming an occlusion in a body lumen (e.g., in a vessel). More specifically, embodiments of the present invention involve securing at least a portion of the occlusion as well as removing at least a portion of the occlusion from the body lumen. Accordingly, devices, systems, and methods described herein may increase passageway through the body lumen, which, in some instances, may improve and/or at least partially restore fluid flow therethrough. | 12-11-2014 |
20150045877 | REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES - The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well. | 02-12-2015 |