Cirillo, US
Brendan P. Cirillo, Merrimack, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20150098617 | Method and Apparatus for Establishing a North Reference for Inertial Measurement Units using Scene Correlation - A scene correlation-based target system and related methods are provided. A reference image depicts a remotely-positioned object having identifiable characteristics, wherein a reference directional vector is established relative to the reference image. A target image of a general vicinity of the remotely-positioned object has an unknown directional vector, the target image having at least a portion of the identifiable characteristics. An inertial measuring unit has a scene correlation system, wherein the scene correlation system matches the portion of the identifiable characteristics of the target image with the identifiable characteristics of the reference image, wherein a slew angle between the reference image and the target image is calculated. A target image directional vector is derived from the calculated slew angle and the reference directional vector. | 04-09-2015 |
James Cirillo, Cleveland Hts., OH US
| Patent application number | Description | Published |
|---|---|---|
| 20110058182 | PROBE FOR DETERMINING AN ABSOLUTE POSITION OF A ROD OF A CYLINDER - A probe for determining an absolute position of a rod relative to a cylinder with the rod having an associated pattern for indicating position includes a light source for emitting light. The probe further includes a light pipe for directing light emitted by the light source onto the pattern of the rod. A detector of the probe detects light and provides a signal indicative of the detected light. A lens produces an image of a portion of the pattern illuminated by the light on the detector and a controller is responsive to the signal from the detector for determining an absolute position of the rod relative to the cylinder. | 03-10-2011 |
James Cirillo, Cleveland Heights, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20130319223 | OPTICAL SENSOR ENCLOSURE WITH INTEGRAL WINDOW AND OPTICAL ALIGNMENT FEATURES - An enclosure for a position sensor includes a housing and a lower Cassette that cooperate to provide a sealed volume in which a sensor assembly is enclosed and protected. The sensor assembly includes a light source and a light detector. The sensor assembly further includes a light pipe that guides light from the light source onto a target and a lens that guides reflected light from the target onto the light detector. The lower cassette is transparent to the light produced by the light source and includes an integral window through which the light enters and exits the lower cassette. An upper cassette supports an upper portion of the light pipe and the lens. A recess adjacent the window supports a lower portion of the light pipe and the lens in the lower cassette, and the upper cassette is received in a receptacle formed inside the lower cassette. | 12-05-2013 |
| 20130319224 | FLOATING OPTICAL SENSOR MOUNT - A piston-cylinder actuator includes a unique mount for an absolute-position sensor. The mount is made from a bearing material provides a flexible connection between the sensor mount and the cylinder housing. This flexible connection allows the piston rod to deflect naturally, under its own weight or under other laterally-directed forces, while maintaining the distance and perpendicularity between the sensor and the rod surface, within acceptable limits. The sensor mount is made from a bearing material that will allow it to float directly on the rod surface without scuffing or otherwise damaging the rod surface, particularly the markings or other indicia on that surface. Due to the flexible connection between the sensor mount and the cylinder housing, the proper distance between the sensor and the rod surface can be maintained at all times. | 12-05-2013 |
| 20130341496 | OPTICAL SENSOR AND MOUNTING INTERFACE - A sensor includes an enclosure having a housing and a lower cassette that cooperate to provide a sealed volume in which an optical sensor assembly is enclosed and protected. The optical sensor assembly includes a circuit board with a light source and a light detector. The sensor assembly further includes a light pipe that guides light from the sensor onto a target and a lens guides reflected light from the target onto the light detector. Lower ends of the light pipe and the lens are supported by a recess in the lower cassette. Upper ends of the light pipe and the lens are supported by an upper cassette. The upper cassette is positively located and mounted to the circuit board and received in an internal receptacle in the lower cassette. Mounting the lower cassette to the housing encloses the optical sensor assembly in the proper alignment. | 12-26-2013 |
James A. Cirillo, Windham, NH US
| Patent application number | Description | Published |
|---|---|---|
| 20140192507 | LIGHTNING PROTECTION AND ENHANCED EMI SHIELDING FOR FACETED DOMES - A faceted dome assembly for airborne optical sensors to enhance EMI shielding and lightning protection is disclosed. In one embodiment, the faceted dome assembly includes a faceted dome. An optical sensor and a gimbal are housed in the faceted dome. Further, a conductor is disposed substantially in the facets of the faceted dome to provide the enhanced electromagnetic shielding and lightning protection. | 07-10-2014 |
Jeffrey D. Cirillo, College Station, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100047172 | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics - Provided herein are imaging methods for detecting, diagnosing and imaging pathogenic bacteria or a pathophysiological condition associated therewith using fluorescent, luminescent or colorimetric detection agents, e.g., fluorogenic substrates for bacterial enzymes, caged luciferins and fluorescent proteins, luciferases and enzymes expressed by recombinant bacteria. Signals emitted by the fluorescent, luminescent or colorimetric detection agents in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Also provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring fluorescence or luminescence emitted from the detection agents in the presence and absence of the potential therapeutic agent. In addition, a method for detecting a pathogenic bacteria via PET or SPECT imaging using a positron-emitting or gamma-emitting substrate for a beta-lactamase or other enzyme or protein of the pathogenic bacteria. Further provided are the fluorogenic substrates CNIR-7 or CNIR7-TAT or the radiolabeled substrates. | 02-25-2010 |
| 20110020240 | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics - Provided herein are imaging methods for detecting, diagnosing and imaging pathogenic bacteria or a pathophysiological condition associated therewith using fluorogenic substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrates or enzyme products in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring a signal emitted from the fluorogenic substrates or products in the presence and absence of the potential therapeutic agent. In addition, a diagnostic method for detecting a mycobacterial infection in a subject by contacting biological samples with a fluorogenic substrate and imaging for signals emitted from a mycobacterial beta-lactamase product. Provided are fluorogenic substrates CC1, CC2, CHPQ, CR2, CNIR1, CNIR2, CNIR3, CNIR4, CNIR5, CNIR5-QSY22, CNIR7, CNIR9, CNIR10, CNIR-TAT, CDC-1, CDC-2, CDC-3, CDC-4, CDC-5, XHX2-81, XHX2-91, XHX3-26, or XHX3-32 or a derivative thereof. | 01-27-2011 |
| 20130164221 | USE OF BACTERIAL BETA-LACTAMASE FOR IN VITRO DIAGNOSTICS AND IN VIVO IMAGING, DIAGNOSTICS AND THERAPEUTICS - Provided herein are methods for detecting, quantifying, differentiating, diagnosing and imaging pathogenic bacteria or condition associated therewith using substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrates or enzyme products in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring a signal emitted from the substrates or products in the presence and absence of the potential therapeutic agent and a diagnostic method for detecting a mycobacterial infection in a subject by contacting biological samples with a substrate and imaging for signals emitted from a mycobacterial beta-lactamase product. Also provided are fluorogenic substrates or substrates comprising a colored dye or a chemical reagent effective to induce a color or pH change. | 06-27-2013 |
| 20140127712 | USE OF BACTERIAL BETA-LACTAMASE FOR IN VITRO DIAGNOSTICS AND IN VIVO IMAGING, DIAGNOSTICS AND THERAPEUTICS - Provided herein are assays and in vitro methods to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. Also provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product. | 05-08-2014 |
| 20140221829 | LOCALIZED FLUORESCENCE EXCITATION IN WHOLE BODY OPTICAL IMAGING - Methods and systems for whole body optical imaging using localized fluorescence excitation. | 08-07-2014 |
| 20150219653 | 2,7-DISUBSTITUTED CEPHALOSPORIN DERIVATIVES AS BETA-LACTAMASE SUBSTRATES AND METHODS FOR THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS - β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis. | 08-06-2015 |
John M. Cirillo, Oxford, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20080306571 | Devices For Treatment of Central Nervous System Injuries - A device for stimulating axon growth of the nerve cells in the spinal cord of mammals includes a device having a DC stimulus generator ( | 12-11-2008 |
Louis Cirillo, Blacksburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20150022362 | WEARABLE DEVICE CONFIGURED TO DETECT IMPROPER MOVEMENT OF A KNEE AND ALERT WEARERS TO THE IMPROPER MOVEMENT - A wearable device may be configured to detect and alert wearers to improper movements at a body joint based on a comparison of a lateral angle and a bend angle of the body joint and/or based on measurements customized for an individual wearer of the wearable device. For example, a wearable device may determine a bend angle and a corresponding lateral angle of the knee. The wearable device may compare the determined bend angle and lateral angle with stored thresholds customized for the wearer. The wearable device may select a threshold from the stored thresholds with a bend angle that matches the determined bend angle. The wearable device may then determine whether the determined lateral angle matches and/or exceeds one or more lateral angles associated with the bend angle of the threshold. The wearable device may provide feedback responsive to a determination that the threshold was exceeded. | 01-22-2015 |
Louis R. Cirillo, Blacksburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20160003612 | RAPID AND ACCURATE THREE DIMENSIONAL SCANNER - A scanner system may include at least one linear actuator and/or at least one scanning platform on each of the at least one linear actuator. Each scanning platform may include an optical sensor configured to detect a two-dimensional contour on an object from a position on the at least one linear actuator, the at least one linear actuator moves a respective scanning platform linearly along a respective axis, and the scanner system records a group of two-dimensional contours of the object detected by the optical sensor of each scanning platform at a group of positions on the at least one linear actuator to compose a three-dimensional contour of the object. | 01-07-2016 |
Pier Francesco Cirillo, Woodbury, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20080312185 | SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES - Disclosed are methods of treating cancer by administration of compounds according to formula (I): | 12-18-2008 |
| 20100009964 | Compounds Which Modulate The CB2 Receptor - Compounds of formula (I) are disclosed. Compounds according to the and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 01-14-2010 |
| 20100261708 | Diazepane Compounds Which Modulate The CB2 Receptor - Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 10-14-2010 |
| 20110071127 | Compounds Which Modulate the CB2 Receptor - Compounds of formula (I) | 03-24-2011 |
| 20110130431 | Compounds Which Modulate The CB2 Receptor - Compounds of formula (I) | 06-02-2011 |
| 20110190256 | Amine and Ether Compounds Which Modulate The CB2 Receptor - Compounds which modulate the CB2 receptor are disclosed. The compounds are useful for treating CB2 receptor-mediated diseases such as pain. | 08-04-2011 |
| 20110312944 | Heterocyclic Compounds Which Modulate The CB2 Receptor - Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 12-22-2011 |