Cicala, US
Claudia Cicala, Bethesda, MD US
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20090285815 | IMMUNOCONJUGATES COMPRISING CD4 AND IMMUNOGLOBIN MOLECULES FOR THE TREATMENT OF HIV INFECTION - Nucleic acids encoding recombinant CD4-fusion proteins are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a mammalian immunoglobulin heavy chain. The portion of the IgG is fused at its C-terminus with a polypeptide comprising a tailpiece from the C terminus of the heavy chain of an IgA antibody or a tailpiece from a C terminus of the heavy chain of an IgM antibody. Also disclosed herein are methods for using these CD4-fusion proteins. | 11-19-2009 |
20110086024 | USE OF ANTAGONISTS OF THE INTERACTION BETWEEN HIV GP120 AND A4B7 INTEGRIN - Methods are provided for the treatment of a HIV infection. The methods can include administering to a subject with an HIV infection a therapeutically effective amount of an agent that interferes with the interaction of gp120 and α4 integrin, such as a α4β1 or α4β7 integrin antagonist, thereby treating the HIV infection. In several examples, the α4 integrin antagonist is a monoclonal antibody that specifically binds to a α4, β1 or β7 integrin subunit or a cyclic hexapeptide with the amino acid sequence of CWLDVC. Methods are also provided to reduce HIV replication or infection. The methods include contacting a cell with an effective amount of an agent that interferes with the interaction of gp120 and α4 integrin, such as a α4β1 or α4β7 integrin antagonist. Moreover, methods are provided for determining if an agent is useful to treat HIV. | 04-14-2011 |
John J. Cicala, Livonia, MI US
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20140150090 | CHALLENGE-RESPONSE METHODOLOGY FOR SECURING VEHICLE DIAGNOSTIC SERVICES - A method for locally authenticating a vehicle diagnostic tool with a vehicle using a challenge-response authentication scheme includes: receiving a pairing request from the vehicle diagnostic tool; presenting a user with a challenge through at least one of an audio system and an LCD display associated with the vehicle; receiving a response to the challenge from a user; and authenticating the vehicle diagnostic tool if the response from the user is identical to an expected response. | 05-29-2014 |
Peter Cicala, Wayne, PA US
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20110065714 | SUBSTITUTED QUINAZOLINES - This invention relates to the discovery of 3-and 5-substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim | 03-17-2011 |
20110065735 | SUBSTITUTED QUINAZOLINES - This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim | 03-17-2011 |
20110130413 | SUBSTITUTED QUINAZOLINES - This invention relates to the discovery of prodrugs of substituted analogues of the selective platelet lowering agent anagrelide which have reduced potential for cardiovascular side-effects and which should therefore lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to prodrugs of certain imidazoquinazoline derivatives which have the general formula (I) shown below wherein the substituents have the meanings defined in claim | 06-02-2011 |
20110152298 | IMIDAZO [2,1-B] QUINAZOLIN-2-ONE DERIVATIVES AND THEIR USE AS PLATELET ANTI-AGGREGATIVE AGENTS - This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below where the substituents have the meanings defined in claim (I) and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets. | 06-23-2011 |
Robert J. Cicala, Rochester Hills, MI US
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20080229667 | DIRECT DRIVE SLIDER WINDOW ASSEMBLY - A slider window assembly for a motor vehicle includes a peripheral frame, at least one fixed panel located within the frame and adjacent an opening and a slider panel located within the frame and movable between a closed position wherein the slider panel covers the opening and an open position wherein the slider panel does not entirely close the opening. A drive assembly is operably connected to the slider panel to selectively move the slider panel between the closed and open positions. The drive assembly includes a rack secured to the slider panel, an electric motor secured to a fixed position on the slider window assembly, and a gear operably connected to the motor and operably engaging the rack so that operation of the motor in opposite directions moves the slider panel in opposite directions between the closed and open positions. | 09-25-2008 |
Robert John Cicala, Rochester Hills, MI US
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20090038229 | MODULAR DROP-GLASS WINDOW ASSEMBLIES - Modular drop-glass window assemblies include a vertically slidable pane, at least one stationary pane having an inboard vertical edge proximate to the exterior surface of the slidable pane and framing holding the stationary pane(s) and at least partially defining a window opening that is opened and closed by movement of the slidable pane. The framing includes vertical frame portions defining run channels for guiding the slidable pane between its open and closed positions. No portion of the vertical frame portions extends exteriorly beyond the plane of the exterior surface of a stationary pane. | 02-12-2009 |
20090113802 | FLUSH DROP-GLASS WINDOW MODULE - A window assembly includes a stationary glazing panel, a moving glazing panel, and a drive mechanism to selectively move the moving glazing panel. A window frame supports the stationary glazing panel. A mounting frame is located at least partially below the moving glazing panel and is configured to capture any water entering the vehicle at the moving glazing panel and to direct the water to a drain. Outer surfaces of the glazing panels are flush to each other. In one disclosed embodiment, tops of the stationary glazing panel and the moving glazing panel are exposed. In another disclosed embodiment, the side and top of the stationary glazing panel are flush mounted. In another disclosed embodiment, the side and top of the stationary glazing panel is flush mounted and a trim member visually covers the top of the moving glazing panel when the moving glazing panel is in the closed position. | 05-07-2009 |
20120137593 | Multi-Pane Window Assembly with Two-Sided Frame and Sliding Pane - A window assembly includes fixed panes, a sliding pane, and a vehicle mounting frame. The mounting frame includes a single, unitary, substantially full-circumference frame member and reinforcement at least partly embedded in the frame member. Interior surfaces of the fixed panes are bonded to the frame member, and the exterior surface of the fixed panes are free of the frame. At least a laterally outboard portion of the peripheral edge of each fixed pane is covered by the frame member. A surface of the window assembly for at least a laterally extending portion of the window assembly above or below the window opening. | 06-07-2012 |
Stephen M. Cicala, Dearborn Heights, MI US
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20090118993 | Adapting Indicated Engine Torque During Regeneration of a Diesel Particulate Filter - In a motor vehicle powertrain that includes a diesel engine, a particulate filter and a torque converter, a method for correcting an indicated engine output torque includes estimating a magnitude of torque being transmitted from the engine to the torque converter while regenerating the particulate filter, determining a reference magnitude of current engine torque being produced while regenerating the particulate filter, determining a torque error from a difference between the estimated magnitude and the reference magnitude, recording the torque error, determining a current torque error from the recorded torque error using a current engine speed and a current reference engine torque as indices to the recorded engine toque error, producing a corrected engine torque from the sum of the current torque error and the current reference engine torque, and using the corrected engine torque to control operation of the transmission. | 05-07-2009 |
20140371999 | PRIMING A START-STOP VEHICLE TRANSMISSION PUMP - A method of controlling a start-stop vehicle transmission pump, includes: assessing how long an engine has been turned off; and when the engine has been turned off for longer than a predetermined threshold and the vehicle is on, priming the transmission pump. | 12-18-2014 |
Stephen Michael Cicala, Dearborn Heights, MI US
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20140069759 | Transmission and Method of Controlling Clutch During Ratio Change - A transmission and control method are disclosed which ensure proper stroke pressure and minimize torque transients during a shift event. The transmission includes a clutch having a torque capacity based on a fluid pressure, a torque sensor adapted to measure a torque value that varies in relationship to the torque capacity, and a controller. The method includes varying the fluid pressure around a predetermined value, measuring a resulting torque difference with the torque sensor, and adjusting a clutch control parameter if the resulting torque difference is less than a threshold value. | 03-13-2014 |
20140350810 | Transmission and Method of Controlling Clutch During Ratio Change - A transmission and control method are disclosed which ensure proper stroke pressure and minimize torque transients during a shift event. The transmission includes a clutch having a torque capacity based on a fluid pressure, a torque sensor adapted to measure a torque value that varies in relationship to the torque capacity, and a controller. The method includes varying the fluid pressure around a predetermined value, measuring a resulting torque difference with the torque sensor, and adjusting a clutch control parameter if the resulting torque difference is less than a threshold value. | 11-27-2014 |
Steve Michael Cicala, Dearborn Heights, MI US
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20120115679 | METHOD FOR CONTROLLING A TRANSMISSION COUPLED TO AN ENGINE THAT MAY BE AUTOMATICALLY STOPPED - Methods and systems for controlling a transmission coupled to an engine during an engine start are presented. In one example, a method adjusts a transmission tie-up force in response to an indication of transmission slip. The method may improve vehicle launch for stop/start vehicles. | 05-10-2012 |
20150038294 | METHOD FOR CONTROLLING A TRANSMISSION COUPLED TO AN ENGINE THAT MAY BE AUTOMATICALLY STOPPED - Methods and systems for controlling a transmission coupled to an engine during an engine start are presented. In one example, a method adjusts a transmission tie-up force in response to an indication of transmission slip. The method may improve vehicle launch for stop/start vehicles. | 02-05-2015 |