Patent application number | Description | Published |
20090118267 | INDANES - Compounds of the formula (I), in which R | 05-07-2009 |
20090163556 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS - The present invention relates to glycinamide derivatives of formula I, | 06-25-2009 |
20090253688 | Semicarbazide derivatives as kinase inhibitors - The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 10-08-2009 |
20090298885 | METHYLENE UREA DERIVATIVES - The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 12-03-2009 |
20130158076 | Methylene Urea Derivatives - The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. | 06-20-2013 |
Patent application number | Description | Published |
20090001669 | Sliding Element, in Particular Piston Ring, Method for Manufacturing a Sliding Element, Sliding System and Coating for a Sliding Element - A sliding element comprises at least one surface for sliding contact with a running face, wherein a wear layer and a run-in layer made from carbon are applied to the surface, and is characterized in that the run-in layer comprises hydrogen and nanocrystalline carbide phases. In a method for manufacturing a sliding element, the run-in layer is applied by means of a PVD process. A sliding system has an above-described sliding element and a body having a running face. A coating for a sliding element comprises a wear layer which can be applied to the upper side of the sliding element, and a run-in layer which is configured as a carbon layer, and is characterized in that the run-in layer comprises hydrogen and nanocrystalline carbide phases. | 01-01-2009 |
20100044968 | PISTON RING FOR INTERNAL COMBUSTION ENGINES - The invention relates to a piston ring which is produced from a carrier material, especially steel or a cast material. The piston ring has a wear-resistant coating from a periodic multilayer system, every periodicity consisting of at least two individual metal nitride layers. Adjacent individual layers within the periodicity have different metallic elements. The thickness of an individual layer is ≧15 nm. | 02-25-2010 |
20100044969 | PISTON RING FOR INTERNAL COMBUSTION ENGINES - The invention relates to a piston ring which is produced from a carrier material, especially steel or a cast material. The piston ring has a wear-resistant coating from a periodic multilayer system, every periodicity consisting of at least two individual metal nitride layers. The multilayer system has superlattice structures, the thickness of an individual layer being ≧2 nm to <15 nm and the thickness of the multilayer system being >4.5 μm and adjacent individual layers within the periodicity having different metallic elements. | 02-25-2010 |
20100171272 | PISTON RING - Disclosed is a piston ring comprising a supporting material and a wear-resistant coating. The wear-resistant coating is composed of a ternary system A-B—N which is applied using a PVD process and in which A and B each represent an element form the group encompassing Ti, Zr, Hf, V, Nb, Ta, Cr, Mo W, Al, Si and C, wherein A ≠B and N represents nitrogen. The thickness of the wear-resistant coating amounts to ≧3 μm. | 07-08-2010 |
20100187765 | PISTON RING - In order to avoid burn traces on piston rings, it is proposed to provide the piston ring with a wear-protection coating which consists of a material with a thermal conductivity of at least 180 W/(m.K). At least 5% vol. of the wear-protection coating consists of aluminum nitride. | 07-29-2010 |
20140353923 | PISTON RING - Disclosed is a piston ring ( | 12-04-2014 |
Patent application number | Description | Published |
20090006002 | COMPARATIVE SEQUENCE ANALYSIS PROCESSES AND SYSTEMS - Provided herein are processes for rapidly identifying or determining sequence information in a sample nucleic acid by comparing sample nucleic acid sequence information to reference nucleic acid sequence information or information obtained from reference samples. Also provided are automated systems for conducting comparative sequence analyses. | 01-01-2009 |
20120046178 | PRODUCTS AND PROCESSES FOR MULTIPLEX NUCLEIC ACID IDENTIFICATION - Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the oligonucleotides include distinguishable labels and a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing and detecting the distinguishable label, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the distinguishable label. | 02-23-2012 |
20130017960 | PRODUCTS AND PROCESSES FOR MULTIPLEX NUCLEIC ACID IDENTIFICATION - Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide. | 01-17-2013 |
20130337456 | COMPARATIVE SEQUENCE ANALYSIS PROCESSES AND SYSTEMS - Provided herein are processes for rapidly identifying or determining sequence information in a sample nucleic acid by comparing sample nucleic acid sequence information to reference nucleic acid sequence information or information obtained from reference samples. Also provided are automated systems for conducting comparative sequence analyses. | 12-19-2013 |
Patent application number | Description | Published |
20100303803 | CATENATE FOR IMMUNOSTIMULATION - The invention relates to a multimeric, non-coding nucleic acid molecule for modulating the activity of the human or animal immune system, and to a production method therefor, and to a vaccine containing said multimeric, non-coding nucleic acid molecule. Said multimeric, non-coding nucleic acid molecules can be non-coding nucleic acid molecules that consist of at least two of said molecules (dimer) or assemblies of several non-coding nucleic acid molecules. | 12-02-2010 |
20120093804 | Concatamers for Immunemodulation - The invention relates to a polymeric, non-coding nucleic acid molecule for modulation of the activity of the human and animal immune system as well as a method for the manufacture thereof and a vaccine, comprising the polymeric, non-coding nucleic acid molecule, wherein polymeric, non-coding nucleic acid molecules may be understood as non-coding nucleic acid molecules, comprising at least four covalently bound molecules (tetramer) or are assemblies of more non-coding nucleic acid molecules (high molecular polymers) which are covalently bound to each other. | 04-19-2012 |
20130287814 | DNA Expression Construct - The invention relates to a minimalistic gene expression construct, its transfer into cells and its use for gene expression for molecular-medical applications. According to the disclosure, a DNA construct for gene expression is provided, wherein the construct is a linear and open-chained DNA double strand comprising a promoter sequence, a coding sequence and a termination signal, wherein the construct comprises at least one L-DNA nucleotide. | 10-31-2013 |
20140010830 | Non-Coding Immunomodulatory DNA Construct - The present invention relates to a nucleic acid molecule and its use for the modulation of the immune system. It provides a DNA construct for immunomodulation comprising at least one nucleotide in L-conformation. | 01-09-2014 |
Patent application number | Description | Published |
20120140893 | METHOD AND DEVICE TO DETERMINE THE VALUE OF AN X-RAY TUBE VOLTAGE - The value of a tube voltage of an x-ray tube, used to acquire x-ray projections of a patient in order to generate at least one image in each phase of a multiphase examination, is determined from a contrast-to-noise ratio that establishes the desired image quality of the image in each phase, and the tube current for each tube voltage for each phase is determined given a constantly maintained contrast-to-noise ratio for different tube voltages. For each phase, a value for the dose of x-ray radiation is defined for each different tube voltage and the associated determined tube current. From among the different tube voltages, a tube voltage is set that causes the total dose of x-ray radiation applied to the patient to be as low as possible for all phases of the examination. | 06-07-2012 |
20120140894 | METHOD AND X-RAY DEVICE TO DETERMINE THE VALUE OF THE TUBE VOLTAGE - In a method and x-ray device to determine the value of an x-ray tube voltage to generate at least one image of defined tissue to be examined, at least one provided parameter is used that establishes or describes the desired image quality; based on the dependency of the contrast of the defined tissue to be examined on the spectrum of the x-ray radiation or on the value of the tube voltage of the x-ray tube. The tube voltage is determined also based on a contrast-to-noise ratio that is constantly maintained under consideration of the aforementioned parameter such that the dose of x-ray radiation applied to the patient is optimally low upon setting the value of the tube voltage at the x-ray tube and the acquisition of at least one x-ray projection of the defined tissue. | 06-07-2012 |
20150085971 | METHOD AND SYSTEM FOR THE AUTOMATIC SELECTION OF A SCANNING PROTOCOL - A method is disclosed for automatically selecting a scanning protocol for a tomographic recording of an X-ray image of a patient in that at least one patient-specific value is retrieved in the internal memory of a first computer. The patient-specific value can in particular be a measure of the anticipated X-ray absorption by the patient. The method includes automatically comparing the patient-specific value with retrievably stored reference values, wherein one scanning protocol can be associated with each reference value. Finally, a scanning protocol is automatically selected by way of the first computer using the comparison. Selection is simplified by automation of selection of the scanning protocol since no manual selection of the scanning protocol has to be made. Automatic selection of a suitable scanning protocol is also quicker than a manual selection. | 03-26-2015 |
Patent application number | Description | Published |
20090076084 | WOUND AND MUCOUS MEMBRANE DISINFECTANT - Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilisers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids. | 03-19-2009 |
20100119566 | USE OF A SYNERGISTIC COMPOSITIONS AS A THERAPEUTIC AGENT OR DISINFECTANT - The invention relates to the use of a composition comprising a vitamin, a metal ion, and a surfactant, as a therapeutic agent or disinfectant. The composition has been known as a decontaminant because the same efficiently decomposes DNA. It has now been possible to demonstrate that the agent has surprisingly good compatibility while having a wide-ranging disinfecting effect and is therefore also suitable for other purposes, e.g., for disinfecting or dressing wounds. | 05-13-2010 |
20120070510 | WOUND AND MUCOUS MEMBRANE DISINFECTANT - Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilisers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids. | 03-22-2012 |
20120107415 | COMBINED DISINFECTION AND DECONTAMINATION AGENT HAVING INCREASED EFFECTIVENESS - The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds. | 05-03-2012 |
Patent application number | Description | Published |
20100075175 | LARGE-AREA SEED FOR AMMONOTHERMAL GROWTH OF BULK GALLIUM NITRIDE AND METHOD OF MANUFACTURE - A high-quality, large-area seed crystal for ammonothermal GaN growth and method for fabricating. The seed crystal comprises double-side GaN growth on a large-area substrate. The seed crystal is of relatively low defect density and has flat surfaces free of bowing. The seed crystal is useful for producing large-volume, high-quality bulk GaN crystals by ammonothermal growth methods for eventual wafering into large-area GaN substrates for device fabrication. | 03-25-2010 |
20100189981 | LARGE-AREA BULK GALLIUM NITRIDE WAFER AND METHOD OF MANUFACTURE - The present invention includes a high-quality, large-area bulk GaN seed crystal for ammonothermal GaN growth and method for fabricating. The seed crystal is of ultra-low defect density, has flat surfaces free of bowing, and is free of foreign substrate material. The seed crystal is useful for producing large-volume, high-quality bulk GaN crystals by ammonothermal growth methods for eventual wafering into large-area GaN substrates for device fabrication. | 07-29-2010 |
20110056429 | Rapid Growth Method and Structures for Gallium and Nitrogen Containing Ultra-Thin Epitaxial Structures for Devices - A method for rapid growth of gallium and nitrogen containing material is described. The method includes providing a bulk gallium and nitrogen containing substrate. A first epitaxial material of first thickness is formed over the substrate, preferably with a pseudomorphical process. The method also forms a second epitaxial layer over the first to create a stacked structure. The stacked structure consists of a total thickness of less than about 2 microns. | 03-10-2011 |
20110064100 | Growth Structures and Method for Forming Laser Diodes on or Off Cut Gallium and Nitrogen Containing Substrates - An optical device having a structured active region configured for one or more selected wavelengths of light emissions and formed on an off-cut m-plane gallium and nitrogen containing substrate. | 03-17-2011 |
20110064101 | Low Voltage Laser Diodes on Gallium and Nitrogen Containing Substrates - A low voltage laser device having an active region configured for one or more selected wavelengths of light emissions. | 03-17-2011 |
20110064102 | Growth Structures and Method for Forming Laser Diodes on or Off Cut Gallium and Nitrogen Containing Substrates - An optical device having a structured active region configured for one or more selected wavelengths of light emissions and formed on an off-cut m-plane gallium and nitrogen containing substrate. | 03-17-2011 |
20110262773 | Ammonothermal Method for Growth of Bulk Gallium Nitride - A high-quality, large-area seed crystal for ammonothermal GaN growth and method for fabricating. The seed crystal comprises double-side GaN growth on a large-area substrate. The seed crystal is of relatively low defect density and has flat surfaces free of bowing. The seed crystal is useful for producing large-volume, high-quality bulk GaN crystals by ammonothermal growth methods for eventual wafering into large-area GaN substrates for device fabrication. | 10-27-2011 |
20120199952 | Method for Growth of Indium-Containing Nitride Films - A method for growth of indium-containing nitride films is described, particularly a method for fabricating a gallium, indium, and nitrogen containing material. On a substrate having a surface region a material having a first indium-rich concentration is formed, followed by a second thickness of material having a first indium-poor concentration. Then a third thickness of material having a second indium-rich concentration is added to form a sandwiched structure which is thermally processed to cause formation of well-crystallized, relaxed material within a vicinity of a surface region of the sandwich structure. | 08-09-2012 |
20130064261 | Solid State Laser Device Using a Selected Crystal Orientation in Non-Polar or Semi-Polar GaN Containing Materials and Methods - An edge emitting solid state laser and method. The laser comprises at least one AlInGaN active layer on a bulk GaN substrate with a non-polar or semi-polar orientation. The edges of the laser comprise {1 1−2±6} facets. The laser has high gain, low threshold currents, capability for extended operation at high current densities, and can be manufactured with improved yield. The laser is useful for optical data storage, projection displays, and as a source for general illumination. | 03-14-2013 |
Patent application number | Description | Published |
20100295211 | Method for Producing a Vessel Closure - The invention relates to a method for producing a vessel closure for vessels comprising an opening that is to be closed by the vessel closure, an inner diameter of more than two cm and surrounds a polymer-based sealing element that is arranged in the vessel closure in such a manner that is sealingly rests on the opening of the vessel in the closed state. A polymer material becomes sufficiently free-flowing by warming and is applied to the vessel closure in the region of the sealing element that is to be produced, and optionally, is mechanically formed into the desired shape which it maintains after cooling. The invention also relates to a metal or plastic vessel closures for vessels for receiving drinks or food, and comprises a sealing insert, the material thereof being selected so that the migration of material components into the drink or food, that are a health risk, is prevented. The invention also relates to corresponding materials for said type of sealing inserts and to the use of specific polymers for producing the above-mentioned sealing inserts. | 11-25-2010 |
20150061184 | Method for Producing A Vessel Closure - The invention relates to a method for producing a vessel closure for vessels comprising an opening that is to be closed by the vessel closure, an inner diameter of more than two cm and surrounds a polymer-based sealing element that is arranged in the vessel closure in such a manner that is sealingly rests on the opening of the vessel in the closed state. A polymer material becomes sufficiently free-flowing by warming and is applied to the vessel closure in the region of the sealing element that is to be produced, and optionally, is mechanically formed into the desired shape which it maintains after cooling. The invention also relates to a metal or plastic vessel closures for vessels for receiving drinks or food, and comprises a sealing insert, the material thereof being selected so that the migration of material components into the drink or food, that are a health risk, is prevented. The invention also relates to corresponding materials for said type of sealing inserts and to the use of specific polymers for producing the above-mentioned sealing inserts. | 03-05-2015 |
Patent application number | Description | Published |
20090048161 | Cytokine receptor modulators and uses thereof - The present invention relates to cytokine receptor-binding compounds, such as non-competitive VEGF receptor, IL-1 receptor, IL-4 receptor, or IGF-1 receptor-binding peptides and petidomimetic antagonists, and therapeutic uses of such compounds. The compounds of the present invention may be used in the treatment of cytokine-associated diseases such as proliferative disorders (for example, colon, breast, prostate, and lung cancer), abnormal neovascularization and angiogenesis, age-related macular degeneration, and proliferative and/or inflammatory skin disorders such as psoriasis. | 02-19-2009 |
20090104706 | CYTOKINE RECEPTOR MODULATORS, METHOD OF IDENTIFYING SAME, AND METHOD OF MODULATING CYTOKINE RECEPTORS ACTIVITY WITH SAME - The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining the ability of the peptide to inhibit or promote the oligomerization and/or activation of the receptor by measuring an activity of the receptor in the absence or the presence of the candidate peptide, wherein the non-competitive peptide is selected when the activity of the receptor is measurably lower in the presence of the peptide as compared to in the absence of the peptide so identified. This invention also provides agonists of cytokine receptor activity. Pharmaceutical compositions that comprise the identified peptides are disclosed. Also disclosed are methods for treating patients with a disease or condition associated with abnormal cytokine receptor mediated function or activity such as inflammatory, autoimmune and vascular diseases. | 04-23-2009 |
20100041609 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT - Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases. This invention also discloses an isolated compound having an IL-1R antagonist activity, said compound being selected from the group consisting of: a peptide comprising the amino acid sequence RYTPELX, wherein R, Y, T, P, E, L, refer to their corresponding amino acids, and X is selected from no amino acid and alanine (A); and a derivative of (a) wherein the derivative incorporates one, two or three amino acid modification selected from an amino acid addition, deletion or substitution in the RYTPEL portion of the peptide, and wherein said derivative maintains its antagonist IL-1R activity. | 02-18-2010 |
20100190710 | IL-23 RECEPTOR ANTAGONISTS AND USES THEREOF - The present invention relates to IL-23 receptor antagonists and agonists. The use of IL-23 receptor antagonists in treating autoimmune and inflammatory disorders, as well as methods of identifying IL-23 receptor antagonists and agonists. | 07-29-2010 |
20110014128 | CYTOKINE RECEPTOR MODULATORS, METHOD OF IDENTIFYING SAME, AND METHOD OF MODULATING CYTOKINE RECEPTORS ACTIVITY WITH SAME - The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining the ability of the peptide to inhibit or promote the oligomerization and/or activation of the receptor by measuring an activity of the receptor in the absence or the presence of the candidate peptide, wherein the non-competitive peptide is selected when the activity of the receptor is measurably lower in the presence of the peptide as compared to in the absence of the peptide so identified. This invention also provides agonists of cytokine receptor activity. Pharmaceutical compositions that comprise the identified peptides are disclosed. Also disclosed are methods for treating patients with a disease or condition associated with abnormal cytokine receptor mediated function or activity such as inflammatory, autoimmune and vascular diseases. | 01-20-2011 |
20110144014 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF - The present invention relates to cytokine receptor-binding compounds, such as non-competitive VEGF receptor, IL-1 receptor, IL-4 receptor, or IGF-1 receptor-binding peptides and petidomimetic antagonists, and therapeutic uses of such compounds. The compounds of the present invention may be used in the treatment of cytokine-associated diseases such as proliferative disorders (for example, colon, breast, prostate, and lung cancer), abnormal neovascularization and angiogenesis, age-related macular degeneration, and proliferative and/or inflammatory skin disorders such as psoriasis. | 06-16-2011 |
20150011477 | CCR2 ANTAGONIST PEPTIDES - The invention relates to a peptide comprising the following amino acid sequence Thr-Phe-Leu-Lys or Thr-Phe-Leu-Lys-Cys, useful as a CCR2 non competitive antagonist peptide. | 01-08-2015 |
Patent application number | Description | Published |
20140046266 | DRUG DELIVERY DEVICE AND CARTRIDGE HOLDER FOR A DRUG DELIVERY DEVICE - A drug delivery device is provided comprising a cartridge holder comprising at least one guide track, and a body comprising at least one interaction member adapted and arranged to mechanically cooperate with the at least one guide track. The guide track comprises a first section and a second section, wherein the path which is defined by the first section encloses an angle with the longitudinal axis of the device, wherein the angle which is enclosed by the path defined by the first section with the longitudinal axis is smaller than the angle which is enclosed by the path defined by the second section with the longitudinal axis, wherein, for connecting the cartridge holder to the body, the interaction member is configured to mechanically cooperate with the first section such that the cartridge holder is axially moved and rotated with respect to the body, and the interaction member is configured to mechanically cooperate with the second section such that the cartridge holder is rotated with respect to the body, whereby an axial movement of the cartridge holder with respect to the body is prevented. Furthermore, a cartridge holder for a drug delivery device is provided. | 02-13-2014 |
20140052075 | ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE - An assembly for a drug delivery device is provided comprising a housing, a cartridge holder releasably connectable to the housing, a resilient member, and an interaction member which is configured to mechanically cooperate with the resilient member and with the cartridge holder. The resilient member is configured to rotationally bias the interaction member. The assembly has a locked state where the cartridge holder is connected to the housing, the cartridge holder being obstructed from movement with respect to the housing, and an unlocked state where the connection between the cartridge holder and the housing is released, the cartridge holder being freely moveable with respect to the housing. | 02-20-2014 |
20140074042 | Drive Assembly for a Drug Delivery Device and Corresponding Drug Delivery Device - A drive assembly for a drug delivery device is disclosed. The drive assembly is connectable with a cartridge holder and comprises a housing, a piston rod, the piston rod being movable in a distal direction for drug delivery, and a guide nut, the guide nut being rotatable relative to the housing around an axis of the assembly and provided for guiding the piston rod. A locking means is provided which is enabled to take an engaged state in which the locking means is engaged with the guide nut in order to prevent rotation of the guide nut and to take a disengaged state in which the locking means is disengaged from the guide nut in order to allow rotation of the guide nut. Moreover, a coupling means is provided, the coupling means being rotatable relative to the housing around the axis of the assembly for interaction with the locking means in order to change between the engaged state and the disengaged state of the locking means. | 03-13-2014 |
20140155834 | Locking Interface, Cartridge Holder and Drug Delivery Device Comprising a Locking Interface - A locking interface for locking a cartridge holder onto a main body of a drug delivery device comprises a locking member for locking the cartridge holder onto the main body, a user interface operable by a user, a support member, on which the locking member and the user interface are located, wherein the locking interface is configured such that a force needed for unlocking the cartridge holder and the main body is reducible by operating the user interface. | 06-05-2014 |
Patent application number | Description | Published |
20080254443 | Norovirus detection, methods and compositions therefor - A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described. Further disclosed are methods of detecting norovirus in a sample. | 10-16-2008 |
20120077806 | Deubiquitinase Inhibitors and Methods for Use of the Same - Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds. | 03-29-2012 |
20140357673 | Deubiquitinase Inhibitors and Methods for Use of the Same - Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds. | 12-04-2014 |
20150079115 | Compositions and Methods for Preventing or Relieving Symptoms of Infections - Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection. | 03-19-2015 |
Patent application number | Description | Published |
20090127226 | PROCESS FOR PRODUCING SELF-SUPPORTING TITANIUM AND NICKEL LAYERS - A process for producing a self-supporting layer made of a titanium and nickel alloy with superelastic and/or shape memory properties has the following steps: a substrate entirely or at least mainly made of silicon is provided, a layer of said alloy is applied to a surface of the substrate, the substrate with the desired form is cut out of a wafer or formed by a wafer with the desired form; at least some zones of the lateral surfaces of the substrate adjoining the zones of the surface of the substrate which receive the layer are subjected to an etching process; a layer of said alloy is applied to the surface of the substrate; and the substrate is removed from the applied layer. Also disclosed is a substrate suitable for carrying out the process and an object, in particular an implant, comprising at least one layer produced by this process. | 05-21-2009 |
20100009142 | METHOD FOR THE PRODUCTION OF STRUCTURED LAYERS OF TITANIUM AND NICKEL - A method for the production of a structured metal layer ( | 01-14-2010 |
20100049310 | METHOD FOR COATING A STENT - Method for applying a coating layer to a tubular intraluminal implant, in particular to a vascular support (stent), where the surface of the implant is perforated by a plurality of apertures, and where the coating layer is produced by deposition of material onto the surface of the implant. The implant is first pushed onto a cylindrical holder | 02-25-2010 |
20100145380 | THROMBOSIS FILTER WITH COVER LAYER - A method is provided for applying a cover layer ( | 06-10-2010 |
20120125888 | METHOD FOR PRODUCING A MEDICAL FUNCTIONAL ELEMENT COMPRISING A SELFSUPPORTING LATTICE STRUCTURE - A method for producing a medical functional element having a self-supporting lattice structure which has interconnected webs. The method applies a first layer to the substrate layer, the first layer is structured by an etching process, the structured first layer is under-cut of a wet chemical etching process acting on the substrate layer, the substrate layer is removed in order to form the self-supporting lattice structure, a web constructional layer is applied to the first layer. The method is distinguished by the forming the first web attachment layer which has a smaller layer thickness than the web constructional layer and is intimately bonded to the web constructional layer in such a way that the web attachment layer, together with the web constructional layer, forms the webs of the self-supporting lattice structure. | 05-24-2012 |
20130199713 | METHOD FOR PRODUCING A MEDICAL DEVICE - A method for producing a medical device with a lattice structure, connected at least in some areas to a cover. The lattice structure is arranged on a substrate via the side to be connected to the cover, the lattice structure has the side arranged on the substrate pressed at least partially into the substrate, the lattice structure is coated with a first layer of a sacrificial material. At least some of the interstices of the lattice structure are covered by the first layer, and the first layer with the lattice structure on the side to be connected to the cover forms a substantially closed surface, the substrate is removed, making the side of the lattice structure accessible for connection to the cover. A second layer for forming the cover is applied to the side of the lattice structure previously pressed into the substrate, and the sacrificial material is removed. | 08-08-2013 |