Patent application number | Description | Published |
20110200686 | COMPOSITIONS OF MODULATORS OF THE WNT/B-CATENIN PATHWAY AND AN N-CINNAMYL-N'BENZHYDRYL PIPERAZINE AND THEIR USE IN TREATING NEOPLASTIC CONDITIONS INCLUDING MALIGNANT MELANOMA - The present invention is directed to a composition comprising a modulator of the Wnt/β-catenin pathway or a pharmaceutically acceptable salt thereof and an N-cinnamyl-N′-benzhydryl piperazine or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method of treating a neoplastic condition in a subject by administering the modulator of the Wnt/βcatenin pathway or a pharmaceutically acceptable salt thereof and an N-cinnamyl-N′-benzhydryl piperazine or a pharmaceutically acceptable salt thereof to the subject under conditions effective to treat a neoplastic disorder. | 08-18-2011 |
20110293750 | ACTIVATED WNT-BETA-CATENIN SIGNALING IN MELANOMA - The present invention is directed to a method of determining the prospects for survival of a melanoma patient. This method involves providing a biological sample from a patient diagnosed with melanoma, determining the level of an indicator of Wnt/β-catenin activation in the sample, comparing the level of the indicator of Wnt/β-catenin activation in the sample against a standard level of the indicator of Wnt/β-catenin activation correlated to survival of melanoma, and determining a patient's prospects for survival of melanoma based on the comparison. The present invention also relates to a method of improving survival of melanoma patients, decreasing metastases in melanoma patients, decreasing proliferation of cancer cells in melanoma patients, decreasing melanoma recurrence in melanoma patients, and/or decreasing tumor size in melanoma patients. This involves selecting melanoma patients and subsequently determining and monitoring therapy based on their level of Wnt/β-catenin activation. The selected melanoma patients are treated with a dose of an activator or synergizer of Wnt/β-catenin based on the patient's level of Wnt/β-catenin, under conditions effective, respectively, to improve survival of the selected melanoma patients, to decrease metas-tases in the selected melanoma patients, to decrease proliferation of cancer cells in the selected melanoma patients, to decrease melanoma recurrence in the selected melanoma patients, and/or to decrease tumor size in the selected melanoma patients. | 12-01-2011 |
Patent application number | Description | Published |
20080268219 | MODIFIED COPOLYESTERS AND OPTICAL FILMS INCLUDING MODIFIED COPOLYESTERS - Modified copolyesters having relatively low refractive indices and relatively high glass transition temperatures are disclosed. These modified copolyesters can be used in forming one or more layers in an optical film, such as a multilayer polymer film. | 10-30-2008 |
20110103036 | OPTICAL FILM - An optical film that includes a reflective polarizer and a stretched polymer film is disclosed. The stretched polymer film is laminated to the reflective polarizer, and the stretched polymer film exhibits a refractive index symmetry point at an angle of incidence in air of at least about 60 degrees in a plane of incidence parallel to a direction of greatest stretch. | 05-05-2011 |
20130321915 | GLARE REDUCING GLAZING ARTICLES - Glazing articles that reduce glare include a glazing substrate, and a reflective polarizing film article attached to the glazing substrate. The reflective polarizing film article includes a reflective polarizing film, and a reflection inhibitor layer. The reflective polarizing film articles reduce transmission of polarized light with a polarization block axis that is horizontal, and reduce horizontally polarized light to 90% or less of the horizontally polarized incident visible light. The reflective polarizing film may include a multi-layer film construction. The reflection inhibitor layer may include a tinted layer or an absorptive polarizer layer. Glazing units that reduce glare include at least one glazing substrate, at least one reflective polarizing film, and at least one reflection inhibitor layer. The glazing substrate, reflective polarizing film, and reflection inhibitor layer may or may not be in contact with one another. | 12-05-2013 |
20150044456 | PRIMER COMPOSITIONS FOR OPTICAL FILMS - Articles and laminates include a substrate with a first polyester surface and a second polyester surface, a crosslinked polyurethane-based primer coated on at least the first polyester surface, and an optically clear heat activated adhesive adjacent to the crosslinked polyurethane-based primer. The articles and laminates are prepared by applying a polyurethane-based dispersion and a crosslinker on at least one polyester surface, drying the applied coating, heating while stretching the substrate and the coating to form a crosslinked primer layer on the stretched polyester surface, and applying an optically clear heat activated adhesive onto the crosslinked primer layer. | 02-12-2015 |
Patent application number | Description | Published |
20080204966 | Controlled Transport and Assembly of Nanostructures - Systems and methods for manipulating nanostructures, such as nanospheres, nanodisks, nanowires, and nanotubes. The systems and methods permit the construction of nano-scale contacts, scaffolds, and motors using electric fields that do not require the use of toxic nanostructure materials. The electric fields are imposed on the nanostructures using electrodes having specific shapes and driven with voltages having particular amplitudes, frequencies, and phase differences. The electrode shape and voltage characteristics influence the configuration of the electric fields, which in turn influences the ultimate configuration of the nanostructures. The nanostructures retain their configuration after the electric fields and any transport medium, such as deionized water, are removed. | 08-28-2008 |
20090146767 | Ferromagnetic Nanorings, Mediums Embodying Same Including Devices and Methods Related Thereto - Featured is a magnetic ring structure including at least a vortex magnetic state such as symmetrically and asymmetrically shaped nanorings, having small diameters (e.g., on the order of 100 nm). In particular embodiments, the width and thickness of the asymmetrical nanorings varies as a function of the locations on the circumference so that maxima and minima thereof are located on opposite sides of the nanoring. Also featured are methods for fabricating such symmetrically and asymmetrically shaped nanorings. Also featured are methods for controlling the reversal process so as to thereby create vortex states in such asymmetric nanorings by controlling the field angle. | 06-11-2009 |
20110311791 | SYSTEM AND METHOD FOR PRECISION TRANSPORT, POSITIONING, AND ASSEMBLING OF LONGITUDINAL NANO-STRUCTURES - A method for assembling multi-component nano-structures that includes dispersing a plurality of nano-structures in a fluid medium, and applying an electric field having an alternating current (AC) component and a direct current (DC) component to the fluid medium containing the plurality of nano-structures. The electric field causes a first nano-structure from the plurality of nano-structures to move to a predetermined position and orientation relative to a second nano-structure of the plurality of nano-structures such that the first and second nano-structures assemble into a multi-component nano-structure. | 12-22-2011 |
20110315656 | FERROMAGNETIC NANORINGS, MEDIUMS EMBODYING SAME INCLUDING DEVICES AND METHODS RELATED THERETO - Featured is a magnetic ring structure including at least a vortex magnetic state such as symmetrically and asymmetrically shaped nanorings, having small diameters (e.g., on the order of 100 nm). In particular embodiments, the width and thickness of the asymmetrical nanorings varies as a function of the locations on the circumference so that maxima and minima thereof are located on opposite sides of the nanoring. Also featured are methods for fabricating such symmetrically and asymmetrically shaped nanorings. Also featured are methods for controlling the reversal process so as to thereby create vortex states in such asymmetric nanorings by controlling the field angle. | 12-29-2011 |
20120219772 | SYSTEM AND METHOD FOR PRECISION TRANSPORT, POSITIONING, AND ASSEMBLING OF LONGITUDINAL NANO-STRUCTURES - A method for assembling multi-component nano-structures that includes dispersing a plurality of nano-structures in a fluid medium, and applying an electric field having an alternating current (AC) component and a direct current (DC) component to the fluid medium containing the plurality of nano-structures. The electric field causes a first nano-structure from the plurality of nano-structures to move to a predetermined position and orientation relative to a second nano-structure of the plurality of nano-structures such that the first and second nano-structures assemble into a multi-component nano-structure. | 08-30-2012 |
20130015542 | MAGNETO-ELECTRONIC DEVICES AND METHODS OF PRODUCTION - A magneto-electronic device includes a first electrode, a second electrode spaced apart from the first electrode, and an electric-field-controllable magnetic tunnel junction arranged between the first electrode and the second electrode. The electric-field-controllable magnetic tunnel junction includes a first ferromagnetic layer, an insulating layer formed on the first ferromagnetic layer, and a second ferromagnetic layer formed on the insulating layer. The first and second ferromagnetic layers have respective first and second magnetic anisotropies that are alignable substantially parallel to each other in a first state and substantially antiparallel in a second state of the electric-field-controllable magnetic tunnel junction. | 01-17-2013 |
20140346044 | SYSTEMS AND METHODS FOR SEPARATING METALLIC AND NONMETALLIC PARTICLES IN A MIXED-PARTICLE SUSPENSION - A continuous flow particle separation system for separating metallic and nonmetallic particles from a mixed-particle suspension includes a fluid channeling component defining an input channel and first and second output channels fluidly connected to the input channel at a bifurcated junction, a first electrode and a second electrode arranged proximate the input channel at least partially prior to the bifurcated junction, and an alternating current (AC) electric power source electrically connected to the first and second electrodes. The first and second electrodes have shapes configured to provide a spatially-gradient electric field across the input channel, and the AC electric power source is configured to provide an AC electric potential to the first and second electrodes to cause a separation of the metallic and nonmetallic particles by dielectrophoresis due to a difference in dielectrophoretic forces imposed on the metallic particles relative to those of the nanometallic particles such that first output fluid flow in the first output channel has an enriched concentration of metallic particles and second output fluid flow in the second output channel has an enriched concentration of nonmetallic particles relative to the mixed-particle suspension in said input channel. | 11-27-2014 |
Patent application number | Description | Published |
20100239502 | IN VIVO EXPRESSION ANALYSIS USING ULTRASOUND-INDUCED TRANSFECTION OF REPORTER CONSTRUCTS - The invention features compositions and methods for in vivo expression analysis. The data presented herein demonstrates that ultrasound-enhanced delivery and/or expression of a composition for expression analysis comprising microbubbles vectors as well as a genetic payload, comprising a “always-on” promoter, a “reference” reporter gene, a “query” promoter and an “answer” reporter gene, enables in vivo analysis of gene expression both without requiring prior preparation (especially genetic modification) of the test subject (animal or patient) and without causing long term or systemic effects on the subject. Such an invention can be used, for example, to query the epigenotypic or phenotypic response of the individual subject to a foreign effector substance such as a pyrogen, pharmaceutical compound, pharmaceutical lead compound, an allergen, an autoimmunogene, a toxin, a polyclonal antibody, a monoclonal antibody, an antigen, a lipid, a carbohydrate, a peptide, a protein, a protein-complex, an amino acid, a fatty acid, a nucleotide, DNA, RNA, PNA, siRNA and micro RNA. | 09-23-2010 |
Patent application number | Description | Published |
20110038593 | Optical Fiber Containing Multi-Layered Coating System - The present invention relates to an optical fiber that includes a glass fiber and three or more coatings that encapsulate the glass fiber, where the three or more coatings include a primary coating in contact with said glass fiber, one or more intermediate coatings that surround the primary coating, and a secondary coating that surrounds the intermediate coatings. Both three-coating and four-coating systems are described that afford improve microbend performance. | 02-17-2011 |
20110300367 | Optical Fiber With Photoacid Coating - Disclosed is a composition that includes a photo-curable base composition that contains one or more acrylate-containing compounds; a photoinitiator that activates polymerization of the photo-curable base composition upon exposure to light of a suitable wavelength; and a photo-acid generating compound that liberates an acid group following exposure to the light of the suitable wavelength. Optical fibers that include the cured product of this composition demonstrate enhanced fatigue resistance, extending lifetime in transient, very small bend applications. Optical fiber ribbons that contain these optical fibers are also disclosed. | 12-08-2011 |
20140376867 | OPTICAL FIBER COATING FOR SHORT DATA NETWORK - A hybrid cladding for optical fibers used in short data networks. The hybrid cladding surrounds a glass waveguide fiber and is surrounded by a primary coating. The hybrid cladding has low adhesion to the primary coating. The low adhesion permits stripping of the primary coating from the hybrid cladding without damaging the hybrid cladding and without leaving residue of the primary coating on the surface of the hybrid cladding. The hybrid cladding may be formed by curing a composition that includes a monomer with a radiation-curable functional group, a slip component, and a photoinitiator. The radiation-curable functional group may be a (meth)acrylate group. The slip component may contain silicon or silicone and may further contain a radiation-curable functional group. Silicone di(meth)acrylate is an illustrative slip component. | 12-25-2014 |
Patent application number | Description | Published |
20080294202 | Bone Anchor With Locking Cap and Method of Spinal Fixation - A bone anchor ( | 11-27-2008 |
20100185290 | FLEXIBLE CHAIN IMPLANTS AND INSTRUMENTATION - A flexible chain implant for insertion into an interior volume of a vertebral body. The implant may be implanted in an insertion position for sliding through a cannula and is flexible for packing into the interior volume in an implanted configuration. The implant randomly separates in the implanted configuration. The implant includes a top member and a bottom member, wherein the top and bottom members are coupled to one another at a coupled portion. The top and bottom members preferably each include an inner surface such that the inner surfaces include a plurality of alternating projections and recesses so that the projections are received within the recesses in an insertion position. Alternatively, the implant may include a plurality of substantially non-flexible bodies and a plurality of substantially flexible links interconnecting the bodies. The non-flexible bodies include a plurality of facets and/or abutment surfaces. | 07-22-2010 |
20110144766 | Allograft Bone Plugs, Systems and Techniques - The present invention provides a system, device, instruments and methods for inserting and/or improving the holding strength and purchase of a bone screw, bone pin, or bone dowel in bone. Embodiments include monolithic allograft tissue forms, multi-piece allograft tissue forms, distally expandable portions, partially and fully demineralized portions, and flexible connecting portions. Advantages of the allograft tissue forms of the present invention include improved pedicle screw blackout strength and improved filling of bone voids. Methods for making and instruments and techniques for inserting the augmentation device, system and screws or pins are also disclosed. | 06-16-2011 |
20120253409 | BONE ANCHOR WITH LOCKING CAP AND METHOD OF SPINAL FIXATION - A bone anchor ( | 10-04-2012 |
20130324839 | METHODS AND APPARATUS FOR ESTIMATING THE POSITION AND ORIENTATION OF AN IMPLANT USING A MOBILE DEVICE - Methods and apparatus for providing an overlay image of an implant during a surgical procedure using a mobile computing device are provided herein. The implant may include radio-opaque internal markers adjacent to and defining edges of the implant. The method may include: capturing an image of a imaging display device screen; estimating a pose of the implant based on the relationship between the 2-D positions of the radio-opaque internal markers and the 3-D positions of the radio-opaque internal markers; retrieving or generating a 3-D model image of the implant at the determined pose using the 3-D implant data; and overlaying the 3-D model image onto the image of the implant. The captured image may include the implant and at least two of the radio-opaque internal markers being visible as fiducial markers within the image. The fiducial markers may be 2-D positions of the radio-opaque internal markers in a 2-D plane. | 12-05-2013 |
20140142707 | Flexible Chain Implants and Instrumentation - A flexible chain implant for insertion into an interior volume of a vertebral body. The implant may be implanted in an insertion position for sliding through a cannula and is flexible for packing into the interior volume in an implanted configuration. The implant randomly separates in the implanted configuration. The implant includes a top member and a bottom member, wherein the top and bottom members are coupled to one another at a coupled portion. The top and bottom members preferably each include an inner surface such that the inner surfaces include a plurality of alternating projections and recesses so that the projections are received within the recesses in an insertion position. Alternatively, the implant may include a plurality of substantially non-flexible bodies and a plurality of substantially flexible links interconnecting the bodies. The non-flexible bodies include a plurality of facets and/or abutment surfaces. | 05-22-2014 |
20140249590 | BONE ANCHOR WITH LOCKING CAP AND METHOD OF SPINAL FIXATION - A bone anchor ( | 09-04-2014 |
Patent application number | Description | Published |
20130138745 | METHOD AND APPARATUS FOR MANAGING COMMUNICATION INQUIRIES - A system that incorporates teachings of the present disclosure may include, for example, a processor that can determine a standard inquiry message from an inquiry command captured at a first communication device of a first user. The standard inquiry message can have an importance rating based on an urgency of the inquiry command and based on behavior information associated with the first user. The processor can deliver the standard inquiry message and the importance rating to a communications management agent of a second communication device, where an inquiry indicator accompanies the delivery of the standard inquiry message at the second communication device. Other embodiments are disclosed. | 05-30-2013 |
20130138746 | METHOD AND APPARATUS FOR MANAGING COMMUNICATION EXCHANGES - A system that incorporates teachings of the present disclosure may include, for example, obtaining a message and an importance rating for the message where the importance rating is determined by a second communications management agent of a server based on an analysis of content of the message. The system can access rating feedback information associated with the second communications management agent. A rating accuracy for the importance rating of the particular message can be determined based on the rating feedback information, and the method of providing the message to the intended recipient can be adjusted based on the determined accuracy. Other embodiments are disclosed. | 05-30-2013 |
20130166492 | Digital Rights Management Using a Digital Agent - A method for digital rights management includes a digital agent for contacting a media host. Media content is compared to a user profile and an identification confidence level is assigned to the media based on the comparison. A digital agent contacts a host of the media based on the identification confidence level, the type of media, and the context of the media. The digital agent requests one or more actions of a media host based on user designations concerning information related to the media. The identification confidence level is generated based on a plurality of user characteristic confidence levels which are generated based on media being analyzed. | 06-27-2013 |
20140162609 | PRE-PROCESSING FOR COMMUNICATION SERVICES - A method for providing a communication service includes detecting an initiated communication initiated by a communications device with a processor and a memory. Environmental data for an environment of the communications device is identified based on detecting the initiated communication. The environmental data is used to supplement a communication service requested by the initiated communication. | 06-12-2014 |
20140248856 | METHOD AND APPARATUS FOR MANAGING COMMUNICATION INQUIRIES - A system that incorporates teachings of the present disclosure may include, for example, a processor that can determine a standard inquiry message from an inquiry command captured at a first communication device of a first user. The standard inquiry message can have an importance rating based on an urgency of the inquiry command and based on behavior information associated with the first user. The processor can deliver the standard inquiry message and the importance rating to a communications management agent of a second communication device, where an inquiry indicator accompanies the delivery of the standard inquiry message at the second communication device. Other embodiments are disclosed. | 09-04-2014 |
20140258429 | METHOD AND APPARATUS FOR MANAGING COMMUNICATION EXCHANGES - A system that incorporates teachings of the present disclosure may include, for example, obtaining a message and an importance rating for the message where the importance rating is determined by a second communications management agent of a server based on an analysis of content of the message. The system can access rating feedback information associated with the second communications management agent. A rating accuracy for the importance rating of the particular message can be determined based on the rating feedback information, and the method of providing the message to the intended recipient can be adjusted based on the determined accuracy. Other embodiments are disclosed. | 09-11-2014 |
20140365645 | SYSTEMS AND METHODS FOR REAL-TIME SERVICE ASSURANCE - A system and methods for providing service assurance using real-time monitoring, management and maintenance capabilities to provide customers and vendors with information related to the state of the service. The service assurance domain implements end-to-end functionality with a level of granularity sufficient to diagnose issues to the device and call/session level. | 12-11-2014 |
20150067486 | METHOD AND APPARATUS FOR MANAGING AUTO-CORRECTION IN MESSAGING - A system that incorporates the subject disclosure may include, for example, detecting in a corrected text message an auto-correction by the first communication device of a target word of a group of words, detecting an input command requesting a transmission of the corrected text message to a second communication device, responsive to the detecting of the input command, presenting a correction alert indicating the target word that has been auto-corrected, and in response to the presenting of the correction alert, presenting an option for modifying the target word, where the transmission of the corrected text message to the second communication device is limited to after the option for modifying is presented at the first communication device. Other embodiments are disclosed. | 03-05-2015 |
Patent application number | Description | Published |
20090181665 | SYSTEMS AND METHODS FOR REAL-TIME SERVICE ASSURANCE - A system and methods for providing service assurance using real-time monitoring, management and maintenance capabilities to provide customers and vendors with information related to the state of the service. The service assurance domain implements end-to-end functionality with a level of granularity sufficient to diagnose issues to the device and call/session level. | 07-16-2009 |
20100120382 | Systems and Methods for Dampening TDMA Interference - Systems and methods are disclosed which relate to mitigating the detrimental effects of interference to electronic devices from mobile telephones utilizing any form of time-domain multiplexing technology. A wireless transmitter inside the mobile telephone broadcasts a warning transmission which can be received by affected devices. Once the warning transmission is received by an affected device, the device activates a blanking circuit comprising an actuator and a switch or switches. The switches open for the duration of the interference so that the user does not receive undesired output such as: noise through a speaker, noise through a microphone, or other interference with electrical signals. | 05-13-2010 |
20110296154 | Automated Communication Configuration - A method for use at a user device of a communications network include utilizing a configuration file obtained from a remote device to configure a communication of an application executed at the user device without requiring user input, the configuration file including logic applied by the application to identify, from a plurality of data bearers available to the user device, a select data bearer for use in conducting the communication based on one or more parameters representative of the current operational context of the user device. The user device includes a storage module to store a configuration file obtained from a remote device and a processing module to execute an application, wherein during execution the application is to utilize logic of configuration file to identify, from a plurality of data bearers available to the user device, a select data bearer for use in conducting a communication of the application. | 12-01-2011 |
Patent application number | Description | Published |
20090092155 | METHOD AND APPARATUS FOR CONTROLLING ACCESS TO A COMMUNICATION CHANNEL - A method and an apparatus provide for controlled access to a shared communication medium. Time slots on a forward channel include information regarding status useful for remote units to determine whether a reverse channel is available for seizure. Additionally, information along the forward channel provides guidance to the remote units to control attempts to seize the reverse channel. In one embodiment a remote unit divides a data package into a plurality of portions and attempts to seize the reverse channel using a single portion of the data package which corresponds to one time slot on the reverse channel. It then waits until it receives notification along the forward channel that the first data portion was successfully received before it attempts to send any of the remainder of its data in consecutive time slots on the reverse channel. | 04-09-2009 |
20120304070 | Multilayer Correlation Profiling Engines - A profiling engine is disclosed. The profiling engine collects information from a variety of sources in real time and stores the information in a profile. The profile may have a number of layers, each layer having a number of categories. The profile is made available for use by applications and services. | 11-29-2012 |
20120322429 | Methods and Apparatus for Anonymous User Identification and Content Personalization in Wireless Communication - Methods and apparatus for providing personalized content to a user of a wireless network include establishing an anonymous user identifier and delivering the user identifier to a content provider. Based on the user identifier, communication with a predetermined data source is established or predetermined data content is selected. In some embodiments, a device identifier is provided in addition to the user identifier and device specific, personalized content is delivered to the user. In one example, a device identifier and a user identifier are based on a mobile station serial number and a subscriber identity module, respectively, and are used in an HTTP header. The anonymous user identifier can be based on a subscriber identity module (SIM) serial number, or a hash of the SIM serial number so that user information such as a user phone numbers is not available to content providers. | 12-20-2012 |
Patent application number | Description | Published |
20100158512 | Centrally Managed, Self-Survivable Wavelength Division Multiplexed Passive Optical Network - A centrally-managed, colorless, bi-directional wavelength division multiplexed passive optical network (WDM-PON) architecture. The WDM-PON architecture is self-survivable, and can protect network failures in, for example, distribution/feeder fiber, remote node and laser failure. The WDM-PON architecture requires only N-wavelength channels for N optical network units. | 06-24-2010 |
20100278538 | MILLIMETER WAVE WIRELESS COMMUNICATION SYSTEM - A wireless communication system adapted to transmit data between two locations, for example between a plurality of processors and memory. Digitally coded millimeter waves can be used to transfer data between antenna arrays. A global optical clock can provide network coherence, frequency self-tracking, and a local oscillator signal for data digital symbol coding/decoding and symbol up-down conversion to/from the millimeter wavelength carrier. | 11-04-2010 |
20110206383 | SYSTEMS AND METHODS FOR PROVIDING AN OPTICAL INFORMATION TRANSMISSION SYSTEM - The present invention describes systems and methods of providing optical information transmission systems. An exemplary embodiment of the present invention includes a precoder configured to differentially encode a binary data signal, a duobinary encoder configured to encode the differentially encoded binary data signal as a three-level duobinary signal, an electrical-to-optical conversion unit configured to convert the three-level duobinary signal into a two-level optical signal, and an optical upconversion unit configured to modulate the two-level optical signal onto a higher frequency optical carrier signal and transmit the modulated higher frequency optical carrier signal onto an optical transmission medium. | 08-25-2011 |
Patent application number | Description | Published |
20120321248 | MULTI-STAGE OPTICAL INTERLEAVING - Methods and devices are provided to facilitate production of optical signals that exhibit reduced crosstalk noise and intersymbol interference. In some configurations, a multi-stage optical interleaver, including a first and a second optical interleaver, is used to process a first and a second set of input optical channels. The composite optical output of the multi-stage interleaver includes the first set of optical channels and the second set of optical channels, where each of the first and second set of input optical channels is processed once by the first optical interleaver and once by the second optical interleaver. As such, the first and second sets of input optical channels are each filtered twice using only two optical interleavers. | 12-20-2012 |
20130028603 | METHOD AND APPARATUS FOR PERFORMING TEMPORAL POLARIZATION INTERLEAVING IN AN OPTICAL TRANSMITTING SYSTEM - An optical signal transmitting system, comprising: an optical transmitter including one or more input terminals and an output terminal; and a temporal polarization interleaver including an input terminal and an output terminal, wherein the output terminal of the optical transmitter is communicatively coupled to the input terminal of the temporal polarization interleaver, wherein: the optical transmitter is configured to receive one or more input signals through its one or more input terminals, generate an output signal using the one or more input signals, the output signal including a x-polarized tributary and a y-polarized tributary that is pulse-to-pulse aligned with the x-polarized tributary, and transmit the output signal to the temporal polarization interleaver; and the temporal polarization interleaver is configured to receive the output signal from the optical transmitter and cause a predefined phase delay to one of the x-polarized tributary and the y-polarized tributary. | 01-31-2013 |
20140105615 | METHOD AND APPARATUS FOR GENERATION OF COHERENT AND FREQUENCY-LOCK OPTICAL SUBCARRIERS - A method and apparatus for generating sub-carriers is disclosed. Coherent optical sub-carriers with sub-carrier spacing are generated for carrying an orthogonal frequency division multiplexed (OFDM) signal. Multiple peaks are generated by cascading multiple phase modulators driven by different radio frequency sources. | 04-17-2014 |
20150023667 | SYSTEM AND METHOD FOR COHERENT DETECTION WITH DIGITAL SIGNAL PROCESSION - Aspects of the present invention include apparatus and methods for transmitting and receiving signals in communication systems. A multicarrier generator generates a multicarrier signal. An optical demultiplexer separates the multicarrier signal into separate multicarrier signals. At least one QPSK modulator modulates signals from the separate multicarrier signals. An optical multiplexer combines the QPSK modulated signals into a multiplexed signal. The multiplexed signal is then transmitted. | 01-22-2015 |
Patent application number | Description | Published |
20090137773 | Production Processes and Systems, Compositions, Surfactants, Monomer Units, Metal Complexes, Phosphate Esters, Glycols, Aqueous Film Forming Foams, and Foam Stabilizers - Compositions and methods for making compositions such as RF(Rτ)nQ are provided. The RF group can include at least two —CF3 groups, the Rτ group can be a group having at least two carbons, n can be at least 1, and the Q group can include one or more atoms of the periodic table of elements. RF-intermediates (RF(RT)nQg); Surfactants (RF(RT)nQs); Foam stabilizers (RF(RT)IIQFS); Metal complexes (RF(RT)IIQMC); Phosphate ester (RF(RT)HQPE); Polymers (RF(RT)IIQMU); Monomers (RF(RT)IIQM); Urethanes (RF(Rτ)nQu); and/or Glycols (RF(RT)IIQH) and methods for making the same are provided. | 05-28-2009 |
20110213113 | PRODUCTION PROCESSES AND SYSTEMS, COMPOSITIONS, SURFACTANTS, MONOMER UNITS, METAL COMPLEXES, PHOSPHATE ESTERS, GLYCOLS, AQUEOUS FILM | 09-01-2011 |
20120071689 | PRODUCTION PROCESSES AND SYSTEMS, COMPOSITIONS, SURFACTANTS, MONOMER UNITS, METAL COMPLEXES, PHOSPHATE ESTERS, GLYCOLS, AQUEOUS FILM FORMING FOAMS, AND FOAM STABILIZERS - Production processes and systems are provided that include reacting halogenated compounds, dehalogenating compounds, reacting alcohol's, reacting olefins and a saturated compounds, reacting reactants having at least two —CF | 03-22-2012 |
20120175137 | Fire extinguishing agents, methods for preventing and/or extinguishing combustion, fire extinguishing systems, and production processes - Compositions comprising | 07-12-2012 |
Patent application number | Description | Published |
20100166714 | CARDIOVASCULAR STEM CELLS, METHODS FOR STEM CELL ISOLATION, AND USES THEREOF - The present invention relates to isolation of cardiovascular stem cells, and more particularly to cardiovascular stem cells positive for markers isll | 07-01-2010 |
20100210713 | REGENERATION AND SURVIVAL OF CARDIAC PROGENITORS AND CARDIOMYOCYTES WITH A STRETCH ACTIVATED TRANSCRIPTION FACTOR - The present invention relates generally to the field of cardiovascular repair, and more particularly to methods and compositions for the survival of cells in response to mechanical stress and to the proliferation of postnatal cardiomyocytes. The present invention relates to a nuclear form of Creb312(N) polypeptide which when expressed in a cell promotes cell survival in response to stress such as mechanical stretch stress. Another aspect of the invention relates to the expression of the nuclear form of Creb312(N) polypeptide in a cardiomyocyte promotes propagation or regeneration of the cardiomyocyte. Other aspect relates to methods and compositions for gene therapy for the treatment of cardiac diseases and disorders in a subject comprising increasing the expression of Creb312(N) polypeptide in cells in vivo or ex vivo, such as cardiac cells and cardiac progenitor cells, and in some embodiments, subsequent transplantation of the Creb312 expressing cells into a subject for the treatment of cardiac diseases and disorders in the subject. | 08-19-2010 |
20110033430 | METHODS FOR THE INDUCTION OF A CELL TO ENTER THE ISLET 1+ LINEAGE AND A METHOD FOR THE EXPANSION THEREOF - The present invention relates to methods for the induction and a cell to enter the Islet 1 | 02-10-2011 |
20120009158 | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF - The present invention generally relates to methods and compositions to generate a secondary iPS (2iPS) cell to produce somatic cells of a rare differentiation cell type fate. In some embodiments, the method relates to an increase in efficiency of differentiation and production of high yields of somatic cells of a rare differentiation cell type fate produced from secondary iPS (2iPS) cells as compared to their differentiation from other pluripotent stem cell sources such as ES cells or primary iPS cells. In some embodiments, the present invention relates to compositions, methods and systems for reprogramming a first somatic cell into a primary iPS cell, where the primary iPS cell is then differentiated along a selected linage to produce a second somatic cell, which is then reprogrammed to a secondary iPS cell (2iPS) cell. The 2iPS cell has a high efficiency of differentiating into a cell of the same cell type as the second somatic cell, e.g., a somatic cells of a rare differentiation cell type fate such as but not limited to a ventricular cardiomyocyte, a pancreatic β-cell or a hepatic cell. In some embodiments, the first somatic cell is a fibroblast, or a cardiac cell, but is not limited to cardiac fibroblast cells. In some embodiments, the present invention relates to compositions, methods and systems to produce ventricular cardiomyocytes from secondary induced pluripotent stem cells (iPSC), where the iPSC are themselves generated from ventricular cardiomyocytes. The secondary iPS (2iPS) cell generated from ventricular cardiomyocytes have a higher cardiomyogenic potential and high cardiomyogenic yield as compared to primary iPSC, and are useful in drug discovery, disease modeling and cell-based therapy. | 01-12-2012 |
20120027807 | TISSUE ENGINEERED MYOCARDIUM AND METHODS OF PRODUCTION AND USES THEREOF - The present invention generally relates to a population of committed ventricular progenitor (CVP) cells and their use to generate a tissue engineered myocardium, in particular two dimensional tissue engineered myocardium which is comparable to functional ventricular heart muscle. One embodiment of present invention provides a composition and methods for the production of a tissue engineered myocardium which has functional properties of cardiac muscle, such as contractibility (e.g. contraction force) and numerous properties of mature fully functional ventricular heart muscle tissue. In particular, in one embodiment, a composition comprising the tissue engineered myocardium comprises committed ventricular progenitor (CVP) cells seeded on a free-standing biopolymer structure to form functional ventricular myocardium tissue. | 02-02-2012 |
20120135051 | GENERATION OF VASCULARIZED HUMAN HEART TISSUE AND USES THEREOF - The present invention relates to the generation of vascularized human heart tissue from human primordial Islet1-positive (ISL1+) progenitors, and more particularly the generation of vascularized human heart tissue from human primordial Islet1+ cardiovascular stem cells which are positive for markers ISL1+/NKX2.5−/KDR−. One aspect of the invention relates to isolation of human ISL1+ primordial cells from human pluripotent cells, such as human ES cells or other human pluripotent stem cell sources, wherein the human ISL1+ primordial cells can differentiate into three different lineages; cardiomyocyte lineages, endothelial lineages and smooth muscle lineages. Another aspect relates to use and implantation of the human primordial ISL1+ progenitors into an animal model to generate human vascularized heart tissue, and more particularly, the production of an in vivo humanized model of vascular disease. One embodiment relates to the use of an in vivo humanized model of vascular disease as an assay, for example to assess drug toxicity and/or identify agents which increase and decrease coronary blood flow to the human vascularized heart tissue. Another embodiment relates to the therapeutic use of human primordial ISL1+ progenitors, for example, in one embodiment the invention provides methods for the treatment cardiovascular disorders and/or congenital heart disease in a subject comprising transplanting into subjects vascularized human heart tissue generated from human ISL1+ progenitors. | 05-31-2012 |
20140073687 | EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA) - Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors. | 03-13-2014 |
Patent application number | Description | Published |
20090040453 | Method of plasma beam bombardment of aligning films for liquid crystals - Methods for treating aligning substrates produces uniform alignment of liquid crystals in at least two modes. The method is based on the treatment of liquid crystal aligning substrates with a collimated or partially collimated plasma beam. In one embodiment, the method comprises a step of bombarding an aligning substrate with at least one plasma beam from a plasma beam source at a designated incident angle to align the atomic/molecular structure or the surface profile of the aligning substrate in at least one aligned direction. | 02-12-2009 |
20090152772 | METHOD OF FABRICATING ELECTRO-OPTICAL DEVICES WITH POLYMER-STABILIZED LIQUID CRYSTAL MOLECULES - In a preparation method, a chiral or cholesteric liquid crystal, a photoreactive monomer, and a photoinitiator are disposed in a liquid crystal cell. A principal surface of the liquid crystal cell is illuminated with ultraviolet light selected to have a non-uniform ultraviolet light intensity profile in the liquid crystal cell. The illuminating cooperates with the photoinitiator to polymerize at least a portion of the photoreactive monomer near the principal surface to generate a polymer network having a density corresponding to the non-uniform ultraviolet light intensity profile. The polymer network biases the liquid crystal toward a selected helical alignment direction. In some embodiments, the illuminating includes illuminating with first and second ultraviolet light intensity profiles to produce surface and volume polymer network components. | 06-18-2009 |
20100002177 | LIQUID CRYSTAL ALIGNMENT USING INKJET PRINTED POLYMERS - A method of preparing liquid crystal alignment films using an inkjet printer to control liquid crystal alignment is disclosed. The alignment ink is formulated from a single alignment material or combination of alignment materials to realize desired pretilt angle. The alignment films can be applied with designed patterns of alignment films of different pretilt angle on at least one substrate to achieve pattern-aligned liquid crystal devices. | 01-07-2010 |
20100051194 | POLYMER ENHANCED CHOLESTERIC ELECTRO-OPTICAL DEVICES - The present invention provides liquid crystal devices comprised of a composite of an internal polymer network localized on the substrate surfaces and short-pitch dual-frequency switchable cholesteric liquid crystal that operate in two different modes including in-plane switching (amplitude modulation) and out-of-plane switching (phase modulation). The invention further provides a method of making a liquid crystal device demonstrating uniform lying helical axis where the device comprises a composite of an internal spatially ordered polymer network localized by in-situ photo-polymerization at the surface of the substrate. The invention can be used for flat panel displays, as well as spatial light modulators for applications such as optical waveguides, optical beam scanners, computer-generated holograms, and adaptive optics. | 03-04-2010 |
20100315568 | Liquid crystal devices and methods providing fast switching mode - A liquid crystal device includes carbon nanotube-doped liquid crystal materials that have a fast switching mode. The liquid crystals may be nematic liquid crystals contained in an optically controlled birefringence cell, with a small amount of nanotubes relative to the liquid crystals. The cell may operate between an optical bend state and homeotropic state, where the liquid crystals aligning in a bend state in response to low voltage and transform to a homeotropic state in response to high voltage. The cell may capable of a large change in effective birefringence, or variable effective birefringence enabling self-compensated optical retardation. The liquid crystals may be included with an electro-optical film, which may be formed with polymer encapsulated liquid crystals with the inclusion of at least a small amount of nanotubes sufficient to induce homogeneous liquid crystal dispersion. The electro-optical film may be fabricated by lamination or otherwise onto a substrate. | 12-16-2010 |
20100315585 | Electro-optical device and method for controlling color - The present invention provides an electro-optical device comprising a cell of polymer-stabilized blue phase (PSBP) liquid crystal under an electrical field and a method of controlling the reflection and transmission of an incident electromagnetic radiation such as visible light, by way of controlling the electrical field. The invention exhibits merits such as cost-effectiveness; simpler manufacturability due to the removal of requirements of polarizer and color filter; and fast switching, among others. | 12-16-2010 |
20110007260 | Liquid crystal composition and device thereof - The invention provides a liquid crystal (LC) composition, a LC cell thereof, and a LC device thereof. The LC composition comprises (i) a mixture of two or more nematic liquid crystals, and (ii) at least one chiral dopant. The mixture of the liquid crystals can exist in a blue phase within a temperature range of from about 12-60° C. such as 21-28° C. The LC device can be a blue phase mode liquid crystal display (HPLCD) based on such a room-temperature blue phase LC. The HPLCD requires no alignment, and it exhibits merits such as a fast switching time (e.g. sub-millisecond), a low switching voltage and a large field-induced birefringence, among others. | 01-13-2011 |
20120262662 | BLUE PHASE LIQUID CRYSTAL NANOCOMPOSITES AND DEVICES CONTAINING THE SAME - A composition including nanocomposites formed from blue phase liquid crystals that are stabilized with dopants and nanorods such as metallic nanorods and/or carbon nanotubes. Devices including the compositions are disclosed that provide increases temperature ranges as well as reduction, in threshold voltage and turn on voltage, in addition to the inherent blue phase liquid crystal properties of sub-millisecond response time in the field induced Kerr effect. | 10-18-2012 |
20130027639 | FAST-SWITCHING SURFACE-STABILIZED LIQUID CRYSTAL CELLS - A surface polymer-assisted vertically aligned (SPA-VA) liquid crystal (LC) cell has a surface alignment layer of surface localized polymer nano spikes capable of controlling the pretilt angle of liquid crystal molecules and ensuring fast switching characteristics. The deposition of the polymer nanospikes as a part of the alignment layer is achieved by polymerizing a small amount of a reactive monomer in vertically aligned liquid crystal with or without an applied voltage. Due to the alignment of liquid crystal molecules by the surface alignment layers, the polymerized polymer acts as an internal surface to modify and control the field-induced reorientation of the liquid crystal molecules. The SPA-VA LC cell realizes a stable alignment and the considerable advantage of the formation of polymer spikes via UV irradiation on both substrates of the cell. Furthermore, the switch-off of a SPA-VA is fast due to the enhanced surface anchoring strength by the surface-localized polymer nano spikes. | 01-31-2013 |
20130321754 | Fumed Metal-Oxide Gel-Dispersed Blue-Phase Liquid Crystals and Devices Thereof - The present invention comprises a fumed metal-oxide gel, such as fumed silica gel, that is dispersed into a blue-phase liquid crystal. Adding the fumed silica nanoparticles in blue-phase media leads to the broadening of the blue-phase temperature range and reduces the switching voltage. Additionally, the polarity-controlled nanoparticles of the fumed silica enable the stabilization of thermal-sensitive Bragg reflection property of the blue-phase liquid crystals, which allows their use in active optical elements and fast-switching LCDs. | 12-05-2013 |
20140002781 | SURFACE-STABILIZED IPS LCD | 01-02-2014 |
Patent application number | Description | Published |
20090311312 | Transdermal Hormone Delivery System: Compositions And Methods - A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed. | 12-17-2009 |
20090324697 | TRANSDERMAL HORMONE DELIVERY SYSTEM: COMPOSITIONS AND METHODS - A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed. | 12-31-2009 |