Patent application number | Description | Published |
20090239271 | FERMENTATION BROTH EXTRACTION OF K-252A - Methods for separating K-252a from the cell mass of its parent fermentation broth are disclosed. | 09-24-2009 |
20100144804 | Polymorph of a Pharmaceutical - A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed. | 06-10-2010 |
20100204466 | ONE POT SYNTHESIS OF TETRAZOLE DERIVATIVES OF RAPAMYCIN - A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30° C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane. The solids are dissolved in acetone, treated with butylated-hydroxy toluene (BHT), and the solution concentrated. The process is repeated twice with acetone to remove solvents. At least one stabilizing agent is added, such as BHT at 0.5% before drying. | 08-12-2010 |
20110065930 | PROCESS FOR THE SYNTHESIS OF (2S,3AR,7AS)-OCTAHYDRO-1H-INDOLE CARBOXYLIC ACID AS AN INTERMEDIATE FOR TRANDOLAPRIL - A process for the preparation of (2S,3aR,7aS)-octahydro-1H-indole-20carboxylic acid hydrochloride. | 03-17-2011 |
20110201060 | PROCESS FOR THE PREPARATION OF SCYLLO-INOSITOL - This invention pertains to a process for manufacturing scyllo-Inositol. Specifically, the current invention pertains to a process for converting myo-Inositol to scyllo-Inositol using a bioconversion process. | 08-18-2011 |
20120029048 | PHENYLALKYL N-HYDROXYUREAS FOR TREATING LEUKOTRIENE RELATED PATHOLOGIES - The method of treating patients by administering N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea for treatment of leukotriene related pathologies and compositions for this use. | 02-02-2012 |
20120232284 | Polymorph of a Pharmaceutical - A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed. | 09-13-2012 |
20130190514 | PHENYLALKYL N-HYDROXYUREAS FOR TREATING LEUKOTRIENE RELATED PATHOLOGIES - The method of treating patients by administering N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea for treatment of leukotriene related pathologies, and compositions for this use. | 07-25-2013 |
20130317078 | PHENYLALKYL N-HYDROXYUREAS FOR TREATING LEUKOTRIENE RELATED PATHOLOGIES - The method of treating patients by administering N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea for treatment of leukotriene related pathologies, and compositions for this use. | 11-28-2013 |
20150031731 | POLYMORPH OF A PHARMACEUTICAL - A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed. | 01-29-2015 |