Patent application number | Description | Published |
20090010896 | METHODS AND COMPOSITIONS FOR OPTIMIZED EXPANSION AND IMPLANTATION OF MESENCHYMAL STEM CELLS - Compositions and methods are provided for the optimized expansion and implantation of mesenchymal stem cells into a patient in need thereof. Autologous mesenchymal stem cells (MSCs) to a patient in need of MSCs are harvested, expanded within novel growth parameters under the influence of autologous growth factors located on the patient's platelets. | 01-08-2009 |
20090208464 | MESENCHYMAL STEM CELL ISOLATION AND TRANSPLANTATION METHOD AND SYSTEM TO BE USED IN A CLINICAL SETTING - A system and method for the percutaneous, autologous transplantation of mesenchymal stem cells and progenitor helper cells (PHC) from bone marrow to degenerated intervertebral discs or joints. This method is designed to be used by operating room staff in a clinical setting to isolate a mesenchymal stem cell population and PHC during the same surgical procedure as transplantation. The method can be used as a two step procedure where cells are harvested, then isolated, then reimplanted at a later time. In addition, experimental techniques are described to determine which bone marrow cells should be removed via negative selection to generate a PHC population most likely to regenerate certain tissue types in-vitro as well as which combination of fibrinogen and hyaluronic acid and which degree of gel maceration provides the best matrix for in-vitro and in-vivo regeneration of joints and intervertebral discs. | 08-20-2009 |
20100168022 | Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens - Provided herein are methods of assessing responsiveness to an agent, methods of customizing treatments, methods of screening agents, and methods of treatment. Also provided are systems and kits for carrying out the methods contemplated herein. An exemplary aspect includes a method of assessing whether a subject having a condition, disorder, dysfunction, or disease would respond to treatment with an agent. The method comprises obtaining a stem cell sample from the subject; culturing the sample; exposing the sample to an agent; evaluating the sample in the presence of and in the absence of the agent to create a sample profile; and comparing the sample profile to a reference profile indicative of responsiveness to the agent. The similarity between the sample profile and the reference profile indicates the subject's responsiveness to the agent. | 07-01-2010 |
Patent application number | Description | Published |
20110052533 | Compositions and Methods for Cartilage Repair - Autologous compositions and methods are provided for cartilage repair in patients in need thereof. Some aspects include combinations of platelet-based materials with chondrogenesis inducing agents in the presence or absence of cell-based therapies. | 03-03-2011 |
20110054929 | Stem Cell Marketplace - Computerized methods and systems for a stem cell marketplace are disclosed herein. Aspects of the stem cell marketplace include a registry that includes information and data necessary for a user to optimize a particular stem cell need. Aspects provide uniformity and certainty on how to proceed in personalizing a particular stem cell need, including autologous stem cell needs. | 03-03-2011 |
20110200642 | Compositions and Methods to Promote Implantation and Engrafment of Stem Cells - Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells. | 08-18-2011 |
20110245804 | Methods and Compositions to Facilitate Repair of Avascular Tissue - Compositions and methods are provided for repairing damaged avascular zones, including intervertebral disc, in a patient in need thereof. | 10-06-2011 |
20110276001 | Therapeutic Delivery Device - Methods and device are provided for delivery of biologics to an intervertebral disc. Device described herein include a needle assembly and handle assembly that optimize biologic delivery parameters to a target location within a disc. The needle assembly includes the capability of advancing into the disc at pre-configured pathways that allow for minimized damaged and maximized positioning of the biologic. | 11-10-2011 |
20130084341 | Compositions and Methods to Promote Implantation and Engrafment of Stem Cells - Tissue repair in-vivo depends on acute inflammation, but in many clinical situations the other major components of healing such as blood supply, anabolic hormones, growth factors, and stem cells are lacking. This invention includes compositions consisting of an agent which induces an inflammatory healing response combined with an autologous platelet lysate at a specific concentration which may have demonstrated in-vitro abilities to expand autologous tissue repair cells. | 04-04-2013 |
20130108593 | Mesenchymal Stem Cell Isolation And Transplantation Method And System To Be Used In A Clinical Setting | 05-02-2013 |
20130287753 | Compositions and Methods for Cartilage Repair - Autologous compositions and methods are provided for cartilage repair in patients in need thereof. Some aspects include combinations of platelet-based materials with chondrogenesis inducing agents in the presence or absence of cell-based therapies. | 10-31-2013 |
20140316369 | SUSPENDED PARTICLE DELIVERY SYSTEMS AND METHODS - Embodiments include particle delivery devices and systems and methods of delivering particles to a site. The device and system embodiments include a suspension reservoir which might be a syringe for temporarily storing and delivering a particle suspension. The particle delivery device also includes a mechanical linkage or other structure which allows the suspension reservoir to rotate or otherwise be moved with respect to, or about, a reservoir axis. Rotation or other movement of the suspension reservoir provides a means for maintaining the particles in suspension during particle storage, loading and delivery processes. | 10-23-2014 |
20160003712 | Blood and Marrow Draw Processing Devices and Methods - Apparatus, systems and methods for processing a blood sample. One embodiment comprises an isolation container having at least one sidewall defining an interior volume. The interior volume includes a medial reservoir in fluid communication with proximal and distal reservoirs. The diameter of the medial reservoir is less than the diameter of the proximal and distal reservoirs. Therefore, the isolation container has an interior volume which is roughly hour-glass shaped with the medial reservoir being a substantially narrowed portion or channel between two wider portions. The isolation container is configured such that the buffy coat layer of fractionated blood will be located within and may be accessed from the reduced cross sectional medial reservoir after a centrifuge or other processing step. | 01-07-2016 |
Patent application number | Description | Published |
20100249946 | TRANSCUTANEOUSLY ADJUSTABLE FLUID-FILLED IMPLANTS - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having a self-sealing membrane operably attached to a wall of the implant. The self-sealing membrane provides access for filling the device, and includes a first layer comprising a fabric. The fabric has a first plurality of yarn strands positioned in a first direction, and a second plurality of yarn strands positioned in a second direction. The first and second plurality of yarn strands intersect to form a matrix pattern with cells defined by free spaces between yarn strands. The membrane also includes a first elastomeric material configured to fill the cells as well as form a coating over the first and second plurality of yarn strand, and a second layer comprising a second elastomeric material. The second elastomeric material has a lower durometer than the first elastomeric material. Kits and systems are also disclosed. | 09-30-2010 |
20100249947 | POROUS IMPLANT WITH EFFECTIVE EXTENSIBILITY AND METHODS OF FORMING AN IMPLANT - The implant includes an outer layer of ePTFE which exhibits extensibility normally not associated with ePTFE. The ePTFE is reduced in length by deforming the fibrils between the nodes while maintaining the nodes in a substantially flat configuration. Various implant configurations that can include the outer layer described are also disclosed. | 09-30-2010 |
20140163696 | POROUS IMPLANT WITH EFFECTIVE EXTENSIBILITY AND METHODS OF FORMING AN IMPLANT - The implant includes an outer layer of ePTFE which exhibits extensibility normally not associated with ePTFE. The ePTFE is reduced in length by deforming the fibrils between the nodes while maintaining the nodes in a substantially flat configuration. Various implant configurations that can include the outer layer described are also disclosed. | 06-12-2014 |
20160001038 | TOOL AND METHOD FOR USING SURGICAL ENDOSCOPE WITH SPIRAL LUMENS - An embodiment of the present invention provides for an elongated medical device with a hypotube backbone running through the device, and a spiral lumen spiraled around the backbone along the length of the backbone. The backbone may be formed from a nitinol alloy for increased bendability without compromising axial stiffness. The device may also incorporate a jacket around the hypotube and spiral lumen formed using either melting, molding, bonding, or casting. The spiral lumen may be configured to accommodate a variety of uses, including actuation members (e.g., pull wires), tools, and means for aspiration, irrigation, image capture, and illumination. Additionally, the present invention provides a method for constructing an elongated medical device with a hypotube backbone running through the device, and a spiral lumen spiraled around the backbone along the length of the backbone. | 01-07-2016 |