Patent application number | Description | Published |
20090163463 | Organic Compounds - The present invention concerns a compound of formula (I) | 06-25-2009 |
20090239847 | Organic compounds - The present invention concerns a compound of formula (I) | 09-24-2009 |
20100130506 | Organic Compounds - A compound of Formula I | 05-27-2010 |
20110059989 | 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF AIRWAY DISEASES - A compound of Formula I | 03-10-2011 |
20110230483 | Pyridine and Pyrazine derivative for the Treatment of CF - The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed. | 09-22-2011 |
20110237572 | Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives - A compound of Formula I | 09-29-2011 |
20120071479 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS - Compounds of Formula I: | 03-22-2012 |
20120214800 | Organic Compounds - The present invention concerns a compound of formula (I) | 08-23-2012 |
20120277232 | Pyridine and Pyrazine Derivative for the Treatment of CF - The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed. | 11-01-2012 |
20130012500 | ORGANIC COMPOUNDS - A compound of Formula I | 01-10-2013 |
20130345239 | NOVEL CRYSTALLINE FORM - This invention relates to a new crystalline form of the succinate salt of the epithelial sodium channel (ENaC) blocker 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester, pharmaceutical compositions comprising said crystalline form, uses of said crystalline form and pharmaceutical compositions, and methods for preparing said crystalline form. | 12-26-2013 |
20140113914 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS - Compounds of Formula I: | 04-24-2014 |
20140135329 | Pyridine and Pyrazine derivative for the Treatment of CF - The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed. | 05-15-2014 |
20140171421 | TREATING DISEASES MEDIATED BY BLOCKADE OF THE EPITHELIAL SODIUM CHANNEL WITH PYRAZINE-2-CARBOXAMIDE DERIVATIVES - A compound of Formula I | 06-19-2014 |
20140235632 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS - The present invention concerns a compound of formula (I) | 08-21-2014 |
20150045364 | Pyridine and Pyrazine derivative for the Treatment of CF - The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed. | 02-12-2015 |