Patent application number | Description | Published |
20080213809 | STABLE NAD/NADH DERIVATIVES - The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits. | 09-04-2008 |
20080262386 | ANALYTICAL SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID AND DISPOSABLE INTEGRATED PUNCTURING AND ANALYZING ELEMENT - An analytical system for detecting an analyte in a body fluid comprises a disposable integrated puncturing and analyzing element and a reusable analytical system. The integrated puncturing and analyzing element includes a puncturing element having a tip for generating a puncture wound in a body part and an elongated flat test strip having a top side and a bottom side. The analyzing instrument having a housing has a holder for holding an integrated puncturing and analyzing element, and a coupling unit which is provided such as to couple the puncturing element to a drive by means of which a puncturing movement of the puncturing element is driven, during which it is moved on a path of movement in the puncturing direction during an advancement phase and, after reaching a reversal point of the puncturing movement, is moved opposite to the puncturing direction in a return phase. The puncturing element is arranged to be parallel to the test strip and such as to be mobile with respect to the test strip along the movement path. The integrated puncturing and analyzing element is held in the holder such that, in a sample application position of the test strip, the top side of the test strip is facing upward and, in a puncturing position of the test strip, the tip of the puncturing element is moved beyond an end of the test strip which is its front end in the puncturing direction, in order to generate a puncture wound in a body part. A sample application area for manual application of a drop exiting from the puncture wound of the body part is provided on the top side of the test strip such that, in the sample application position, the drop is applied to the sample application area from directly above. The housing is shaped to allow access to the sample application area of a test strip positioned in the sample application position, and to allow access to the front end of a test strip which is positioned in the puncturing position. | 10-23-2008 |
20090208989 | Fluorescence Spectropscopy In Absorbing Media - The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement. | 08-20-2009 |
20090236238 | Electrochemical Determination of Factor XA Inhibitors - Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal. | 09-24-2009 |
20090246818 | COMPOUNDS, METHODS, COMPLEXES, APPARATUSES AND USES RELATING TO STABILE FORMS OF NAD/NADH - The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices. | 10-01-2009 |
20100144042 | AUTOMATIC DIFFERENTIATION OF A SAMPLE SOLUTION AND A CONTROL SOLUTION - The invention concerns a method for automatically differentiating between a sample liquid and a control liquid especially within the context of analytical measuring systems, wherein the presence of a special property of the control liquid and/or at least two criteria are used for the differentiation. In addition the invention concerns appropriate control liquids that are suitable for the new method. | 06-10-2010 |
20100227348 | METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE USING FLUORESCENCE MEASUREMENT - A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte. | 09-09-2010 |
20110064618 | FLUORESCENCE SPECTROSCOPY IN ABSORBING MEDIA - The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement of a fluorophore, wherein the detection medium which contains a fluorophore or a precursor of the fluorophore is admixed with an absorber whose absorbance spectrum superimposes the fluorescence excitation range of the fluorophore. The system consisting of the fluorophore and the absorber, which is produced in the detection medium, has an altered effective fluorescence excitation range with an altered fluorescence excitation maximum. Illumination with fluorescence excitation light can take place within the range of this altered excitation maximum. The measured signal obtained from determining fluorescence emission exhibits only low dependence on the wavelength of the excitation light. | 03-17-2011 |
20110143416 | STABILIZATION OF DEHYDROGENASES WITH STABLE COENZYMES - The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes. | 06-16-2011 |
20110177605 | On-Board Control for Analytical Elements - The invention concerns a reagent system for the so-called on-board control of analytical elements, in particular test strips, containing an organic N-oxide or a nitroso compound. The invention also concerns analytical elements containing a reagent system for a detection reaction and a reagent system for an on-board control. Furthermore, the invention concerns a method for checking analytical elements in which a reagent system for an on-board control is examined optically or electrochemically with the aid of a measuring instrument for changes which could indicate a stress of the analytical element. | 07-21-2011 |
20120045843 | TEST ELEMENT FOR DETERMINING A BODY FLUID AND MEASUREMENT METHOD - A test element for determining a body fluid, in particular for determining the blood glucose level, comprises a detection region which is charged with a reagent sensitive to the body fluid. A function element is arranged in and/or adjacent to the detection region for detecting at least one status parameter for the detection region, wherein said functional element can be evaluated by means of a status measurement. A method for measuring the test element is also disclosed. | 02-23-2012 |
20120130062 | ENZYMATIC SYNTHESIS OF CARBA-NAD - The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose. | 05-24-2012 |
20120241335 | SIMPLIFIED STORAGE OF INTEGRATED SYSTEMS - Storage containers for storing at least one diagnostic test element including an enzyme and a stabilized coenzyme are disclosed. In addition, diagnostic products which include diagnostic test elements including an enzyme and a stabilized coenzyme, as well as analytical measuring devices which include such storage containers or diagnostic products, are also disclosed. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving test elements which include an enzyme and a stabilized coenzyme. | 09-27-2012 |
20120276565 | STABILIZATION OF ENZYMES WITH STABLE COENZYMES - Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization. | 11-01-2012 |
20130011871 | STERILIZABLE CHEMISTRY FOR TEST ELEMENTS - In one non-limiting aspect, sterilizable reagent materials for diagnostic elements are provided. In other aspects, sterilized diagnostic elements and techniques for the production of the same are disclosed. In one embodiment, a sterilized diagnostic element includes a chemical detection reagent including at least one component that is sensitive to ionizing radiation. The sterilized diagnostic element is also mediator-free and the at least one component sensitive to ionizing radiation is present in a functional form in a proportion of ≧ 80% based on the total amount of the respective component in the diagnostic element before sterilization. In certain aspects, the at least one component sensitive to ionizing radiation includes one or both of an enzyme and a coenzyme. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving sterilizable reagent materials or sterilized diagnostic elements. | 01-10-2013 |
20130217138 | TEST ELEMENT FOR DETERMINING A BODY FLUID AND MEASUREMENT METHOD - A test element for determining a body fluid is provided. The test element, in particular for determining the blood glucose level, includes a detection region which is charged with a reagent sensitive to the body fluid. A function element is arranged in or adjacent to the detection region for detecting at least one status parameter for the detection region, such that the functional element can be evaluated by means of a status measurement. A method for measuring the test element is also disclosed. | 08-22-2013 |
20130303768 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS - A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine. | 11-14-2013 |
20140041443 | ANALYSIS SYSTEM HAVING A MEASUREMENT DEVICE AND TEST ELEMENT - Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device. | 02-13-2014 |
20140106383 | Electrochemical Determination of Factor XA Inhibitors - Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal. | 04-17-2014 |
20140142291 | ENZYMATIC SYNTHESIS OF CARBA-NAD - The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose. | 05-22-2014 |
20140206024 | STABLE NAD/NADH DERIVATIVES - The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits. | 07-24-2014 |
20140212903 | AZO MEDIATORS AND METHODS OF USE THEREOF - Azo compounds are disclosed that do not form azoxy dimers and that do not have any reactive nitroso groups. Also disclosed are use of the azo compounds as mediators in optical and electrochemical diagnostic methods, as well as detection reagents, kits and test elements that include such azo compounds and that can be used in the diagnostic methods. | 07-31-2014 |
20140238118 | ANALYSIS SYSTEM HAVING A MEASUREMENT DEVICE AND TEST ELEMENT - Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device. | 08-28-2014 |
20140242622 | METHODS OF DETECTING TEST ELEMENTS HAVING DEGRADED TEST CHEMICALS AS WELL AS APPARATUSES INCORPORATING THE SAME - An analytical apparatus is disclosed for detecting at least one analyte in a sample, where in an analyte measurement at least an electrical or optical property changeable by presence of the analyte at least one test chemical of a test element is recorded, and where the analytical apparatus also can perform at least one quality measurement on the at least one test chemical such as an intrinsic luminescence, which is recorded and from the intrinsic luminescence a conclusion is drawn on a quality of the test chemical and thus the test element. Methods also are disclosed for detecting at least one analyte in a sample that include a quality measurement of the at least one test chemical of the test strip. | 08-28-2014 |
20140302541 | METHODS OF DETERMINING AN ANALYTE CONCENTRATION, AS WELL AS DEVICES AND TEST ELEMENTS INCORPORATING THE SAME - Methods, devices and test elements are disclosed for detecting at least one analyte in a sample. The methods, devices and test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The methods, devices and test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of a diffusable label. | 10-09-2014 |
20140322737 | FAST REACTION KINETICS OF ENZYMES HAVING LOW ACTIVITY IN DRY CHEMISTRY LAYERS - The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte. | 10-30-2014 |