Patent application number | Description | Published |
20090144617 | METHOD AND SYSTEM FOR FAST, GENERIC, ONLINE AND OFFLINE, MULTI-SOURCE TEXT ANALYSIS AND VISUALIZATION - Methods and systems for text data analysis and visualization enable a user to specify a set of text data sources and visualize the content of the text data sources in an overview of salient features in the form of a network of words. A user may focus on one or more words to provide a visualization of connections specific to the focused word(s). The visualization may include clustering of relevant concepts within the network of words. Upon selection of a word, the context thereof, e.g., links to articles where the word appears, may be provided to the user. Analyzing may include textual statistical correlation models for assigning weights to words and links between words. Displaying the network of words may include a force-based network layout algorithm. Extracting clusters for display may include identifying “communities of words” as if the network of words was a social network. | 06-04-2009 |
20110047455 | Method and System for Fast, Generic, Online and Offline, Multi-Source Text Analysis and Visualization - Methods and systems for text data analysis and visualization enable a user to specify a set of text data sources and visualize the content of the text data sources in an overview of salient features in the form of a network of words. A user may focus on one or more words to provide a visualization of connections specific to the focused word(s). The visualization may include clustering of relevant concepts within the network of words. Upon selection of a word, the context thereof, e.g., links to articles where the word appears, may be provided to the user. Analyzing may include textual statistical correlation models for assigning weights to words and links between words. Displaying the network of words may include a force-based network layout algorithm. Extracting clusters for display may include identifying “communities of words” as if the network of words was a social network. | 02-24-2011 |
Patent application number | Description | Published |
20090022707 | Combinations of Antibodies Selective for a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor and Other Therapeutic Agents - An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth. | 01-22-2009 |
20090208483 | ANTIBODY SELECTIVE FOR DR4 AND USES THEREOF - An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of DR5 and DR4 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth. | 08-20-2009 |
20110002887 | COMBINATIONS OF ANTIBODIES SELECTIVE FOR DR5 AND OTHER THERAPEUTIC AGENTS - An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth. | 01-06-2011 |
20110104143 | Treating Basal-Like Genotype Cancers - Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus TAP repeat (BIR). | 05-05-2011 |
20110293515 | HETEROFUNCTIONAL SEGMENT-POLY (ETHYLENE GLYCOL) POLYMERS AS DELIVERY VEHICLES - Heterofunctional segment-poly(ethylene glycol) polymers, conjugates of these molecules with therapeutic and/or imaging agents, and methods for their use are disclosed. The heterofunctional segment-poly(ethylene glycol) polymers are useful as drug delivery conjugates, i.e., the heterofunctional segment-poly(ethylene glycol) polymers can be covalently attached to therapeutic agents (e.g., pharmaceutically active agents) and serve as delivery vehicles for the therapeutic agents. The heterofunctional segment-poly(ethylene glycol) polymers are also useful as imaging agent conjugates, i.e. the heterofunctional segment-poly(ethylene glycol) polymers can be covalently attached to imaging agents (e.g., tracers, imaging atoms, and imaging molecules) and serve as delivery vehicles for the imaging agents. Also disclosed are methods for treating a subject by administering to the subject an effective amount of the polymers conjugated to a therapeutic agent, an imaging agent, or a mixture thereof. | 12-01-2011 |
20130004521 | TARGETING CANCER STEM CELLS - Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject. | 01-03-2013 |
20140314774 | HER3 ANTIBODIES AND USES THEREOF - Provided herein are antibodies specific for HER3. Also provided are methods of treating cancer in a subject comprising administering an effective amount of the antibodies described herein to the subject. | 10-23-2014 |