Bryan, PA
Alberto Bryan, Philadelphia, PA US
Patent application number | Description | Published |
---|---|---|
20130059794 | ALPHA-FETOPROTEIN "RING AND TAIL" PEPTIDES - The invention relates to compounds that are analogs of a cyclic peptide, cyclo[EKTOVNOGN], AFPep, that has anti-estrotrophic activity. The analogs of the invention include peptides and peptidomimetics that inhibit estrogen receptor-dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer. | 03-07-2013 |
Deborah L. Bryan, Collegeville, PA US
Patent application number | Description | Published |
---|---|---|
20100016318 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE - The present invention relates to a compound represented by the following formula: | 01-21-2010 |
Deborah Lynne Bryan, King Of Prussia, PA US
Patent application number | Description | Published |
---|---|---|
20080287466 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF - Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. | 11-20-2008 |
Janine Bryan, Furlong, PA US
Patent application number | Description | Published |
---|---|---|
20100041097 | Synthetic gene control region - The present invention provides a synthetic gene control region which comprises a gene regulatory sequence comprising a binding site for a gene regulatory protein of a yeast strain, and a promoter from filamentous fungal strain located downstream of the gene regulatory sequence; wherein the promoter can be recognized by the general transcription factors and RNA polymerase of the yeast strain; wherein the gene regulatory sequence is capable of regulating transcription initiated by the filamentous fungal promoter in the yeast strain. | 02-18-2010 |
Janine T. Bryan, Furlong, PA US
Patent application number | Description | Published |
---|---|---|
20080226660 | Optimized Expression of Hpv 58 L1 in Yeast - Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections. | 09-18-2008 |
20080248062 | Papillomavirus vaccine compositions - The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection. | 10-09-2008 |
20100035818 | OPTIMIZED EXPRESSION OF HPV 52 L1 IN YEAST - Synthetic DNA molecules encoding the HPV 52 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV 52 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. In alternative embodiments of the invention, the nucleotide sequence of the synthetic molecule is altered to eliminate transcription termination signals that are recognized by yeast. The synthetic molecules may be used to produce HPV 52 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV 52 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and may also be useful for treatment of existing HPV infections. | 02-11-2010 |
20100189744 | PAPILLOMAVIRUS VACCINE COMPOSITIONS - The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection. | 07-29-2010 |
20100272749 | Optimized expression of HPV 58 L1 in yeast - Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections. | 10-28-2010 |
20120121630 | RECOMBINANT ECTODOMAIN EXPRESSION OF HERPES SIMPLEX VIRUS GLYCOPROTEINS IN YEAST - The present invention provides Herpes Simplex Virus (HSV) gD, gC, gB and/or gE recombinant glycoproteins having a particular pre-selected N-linked glycosylation pattern as the predominant N-glycoform. The present invention also provides methods of producing these recombinant glycoproteins in yeast, preferably | 05-17-2012 |
20120177684 | PAPILLOMAVIRUS VACCINE COMPOSITIONS - The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection. | 07-12-2012 |
Joseph E. Bryan, Glenshaw, PA US
Patent application number | Description | Published |
---|---|---|
20140341649 | Nut and a method of use of the nut in a fastener system for crane mats - The present invention pertains to a nut to be used as part of a fastener to be used in multiple ways in various industries or methods. The nut has a drive mechanism and stud extending from the drive mechanism with a threaded bore. In addition the nut can be specifically used as a method and as part of special fastener that can be used to join cut, hard-wood members, other naturally occurring manufactured mat members or synthetically man made members, referred to as “timber(s)” or “laminated”, in forming a mat used for heavy construction equipment to run on over ground which is not stable. These mats are commonly referred to as “Crane Mats” or “Laminated Mats” in the construction, mining, pipeline, and oil and gas industries among others. | 11-20-2014 |
20150308269 | Mine roof bolt system - This new system can utilize a threaded bolt head on one end of a roof bolt and an anchoring device on the other end of the bolt. The roof bolt is designed in such a manner to allow the bolt head to drive the bolt for anchoring purposes and to allow the bolt head to also serve as the attachment mechanism for ancillary appendages. This system can be utilized as the primary roof bolting system, or, as an ancillary system in conjunction with existing primary roof bolts. | 10-29-2015 |
Patrick H. Bryan, Eighty Four, PA US
Patent application number | Description | Published |
---|---|---|
20100239991 | Furnace Roller Assembly - A furnace roller assembly is provided with a helically shaped shaft-offset and metal product contact surface assembly wound around a furnace roller shaft. A corebuster may be provided within the furnace roller shaft to direct the flow of a coolant within the axial length of the furnace roller shaft and through a cooling element forming a part of the shaft-offset and metal contact surface assembly. | 09-23-2010 |
20140099588 | METHOD FOR FORMING AND USING A FURNACE ROLLER ASSEMBLY - A furnace roller assembly is formed with a helically shaped shaft-offset and metal product contact surface assembly wound around a furnace roller shaft. A corebuster may be provided within the furnace roller shaft to direct the flow of a coolant within the axial length of the furnace roller shaft and through a cooling element forming a part of the shaft-offset and metal contact surface assembly. | 04-10-2014 |
Robert Nicholas Bryan, Philadelphia, PA US
Patent application number | Description | Published |
---|---|---|
20160048956 | SYSTEM AND METHOD FOR MEDICAL IMAGE ANALYSIS AND PROBABILISTIC DIAGNOSIS - Methods and systems for obtaining a probabilistic diagnosis based on medical images of a patient are disclosed. In exemplary embodiments, such methods include the steps of scanning some or all of a patient to obtain a medical image; evaluating the medical image for one or more designated key features; assigning discrete values to the one or more designated key features to form a patient scan key feature pattern; and transmitting the values of the one or more designated key features to a processor programmed to match the patient scan key feature pattern to one or more known disease-specific key feature patterns to create a probabilistic diagnosis and transmit the probabilistic diagnosis to a user. Associated systems include a medical imaging device that is capable of producing a medical image of some or all of a patient and a processor programmed to create a probabilistic diagnosis. | 02-18-2016 |
Wang Bryan, Wyomissing, PA US
Patent application number | Description | Published |
---|---|---|
20100151003 | EGFR BINDING PEPTIDES AND USES THEREOF - Short oligopeptides are provided which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided. | 06-17-2010 |