Patent application number | Description | Published |
20100137163 | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | 06-03-2010 |
20130217583 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | 08-22-2013 |
20140256595 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | 09-11-2014 |
20140323317 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | 10-30-2014 |
Patent application number | Description | Published |
20120301903 | Microfluidic Devices and Methods of Manufacture and Use - Series of bio-detection elements, shown as short hollow transparent reaction vessels ( | 11-29-2012 |
20140377146 | Microfluidic Assay Operating System and Methods of Use - A pneumatically driven portable assay cartridge having analyte capture regions associated with microfluidic channels within its interior, the portable cartridge having pneumatic ports clampable against pneumatic ports of an operating instrument for controlled application of positive pressure and vacuum to pneumatic operating channels within the cartridge, the cartridge having a well for receiving sample from a user and microfluidic channels that include pneumatically operated pistons and valves controllable by the pneumatic operating channels to cause all flows of the assay from the reservoirs through reaction regions within the cartridge to on-board waste reservoir during conduct of the assay. | 12-25-2014 |
20140377852 | Methods and Systems for Epi-Fluorescent Monitoring and Scanning for Microfluidic Assays - An operating and reading instrument for performing an assay employing a portable microfluidic assay cartridge, the instrument comprising a translatable table under automated control, the translatable table carrying a receiving region for the portable cartridge and carrying a port system connectible to the cartridge that includes at least one remotely automated valve carried by the translatable table, the valve arranged to apply pressurized flowable substance at selected times to the cartridge while the cartridge is on the translatable table. | 12-25-2014 |
20150086424 | Micro-Tube Particles for Microfluidic Assays and Methods of Manufacture - A microfluidic assay device that defines a micro-fluidic flow channel ( | 03-26-2015 |
20150087544 | Methods and Systems for Manufacture of Microarray Assay Systems, Conducting Microfluidic Assays, and Monitoring and Scanning to Obtain Microfluidic Assay Results - A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel. | 03-26-2015 |
20150087558 | Microfluidic Assay Systems Employing Micro-Particles and Methods of Manufacture - A method of making an assay device comprising providing micro-elements in the form of micro-particles or micro-length tube detection elements and thereafter with an automated tool, picking and placing the micro-elements into open-sided microfluidic channels in a body. | 03-26-2015 |
20150087559 | PDMS Membrane-Confined Nucleic Acid and Antibody/Antigen-Functionalized Microlength Tube Capture Elements, and Systems Employing Them - A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device. | 03-26-2015 |
Patent application number | Description | Published |
20100021069 | PDF DE-CHUNKING AND OBJECT CLASSIFICATION - Systems and methods are described that facilitate identifying objects in a document (e.g., a PDF document) for automatic image enhancement (AIE). A PDF document is “chunked” or segmented into chunks, and boundaries between chunks are identified as real or imaginary. Chunks sharing imaginary boundaries are combined, while real boundaries are retained, to generate “de-chunked” objects. These objects are then classified, and an AIE application is executed on objects meeting pre-specified classification criteria. In this manner, objects of r which AIE is not desired are not subjected to the AIE application, thereby saving time and processing resources associated with enhancing the document. | 01-28-2010 |
20100054581 | SYSTEM AND METHOD FOR COLOR SPACE CONVERSION WITH REDUCED ARTIFACTS - A method and system convert an original digital image being represented by a first color space to a digital image being represented by a second color space by transforming the original image data represented by a first color space to second image data being represented by a second color space, the transformation causing the colors of the transformed image data to be substantially encodable in the second color space. The second image data represented by the second color space is transformed to third image data represented by the first color space, the transformation causing the colors of the transformed image data to be substantially encodable in the first color space. Distortions in the third image data represented by the first color space are corrected to form corrected image data represented by the first color space, and the corrected image data represented by the first color space is transformed to fourth image data represented by the second color space. | 03-04-2010 |
20100272355 | ADAPTIVE SPATIAL GAMUT MAPPING VIA DYNAMIC THRESHOLDING - What is disclosed is a novel system and method for performing spatial gamut mapping on a received input color image having a plurality of pixels. A standard gamut-mapping algorithm is applied to the input color image to produce a gamut-mapped color image. A difference is computed between a selected channel of the input color image and the gamut-mapped image to produce a difference image. A local measure of complexity is derived for a given pixel in the difference image. One or more parameter values of a spatial bilateral filter are obtained from a lookup table based on the computed local measure of complexity. The spatial bilateral filter is applied, using the obtained parameter values, to the current pixel of the difference image to produce a modified pixel in a modified difference image. Thereafter, a modified gamut-mapped color image is obtained from the modified difference image and the gamut-mapped color image. | 10-28-2010 |
20150043039 | SYSTEM FOR CREATING CERTIFIED DOCUMENT COPIES - To print a certified document, a user may select or a system may receive a selection of a document to be certified. The system identifies a security template to be used based on the document and/or capabilities of the print device on which the document will be printed. The system may display the document with a non-secure overlay of the selected security template, add a unique security element to the document according to the template, and cause the document to be printed at the selected print device with the added security element without permitting the added security element to be fully displayed or printed on any other device. | 02-12-2015 |