Bissell, US
Allen M Bissell, Virginia Beach, VA US
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20150296721 | Methods and Apparatus for Affecting an Atmospheric Cyclone - Methods and apparatus for affecting atmospheric cyclones and quantifying parameters related to affected cyclones are disclosed. These methods and apparatus involve attacking a cyclone chemically, without the use of explosives, with an energy transfer inhibitor that can interfere with the transmission of energy from the sea surface to the cyclone. The energy transfer inhibitor, if properly chosen and placed in a desired path of the storm, can deny one part of the storm energy from the latent heat of vaporization of water, thereby creating an imbalance in the centrifugal force of the cyclone. The imbalance can reduce the intensity of the cyclone and can be used to steer the storm. Quantifying parameters associated with an affected cyclone enables forecasting the cyclone's energy state, path, intensity, or other related parameters and evaluating possible additional energy transfer inhibitor distribution. | 10-22-2015 |
Allen M. Bissell, Chevy Chase, MD US
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20150090805 | Methods and Apparatus for Destabilizing Tornadoes - Methods and apparatus for destabilizing and reducing the strength and even destroying tornadoes are disclosed. Rather than over-powering a tornado, tornado vulnerabilities in stability maintenance are identified and turned against the tornado. Embodiments include attacking tornado vulnerabilities chemically without the use of explosives. Selected chemicals are introduced into a tornado adjacent to the wall of the funnel, advantageously above the height of entrained debris, to reduce the transmission of local angular velocity of the funnel toward the earth and to attack the local generation of energy from the tornado's air/water mixture. | 04-02-2015 |
20150296721 | Methods and Apparatus for Affecting an Atmospheric Cyclone - Methods and apparatus for affecting atmospheric cyclones and quantifying parameters related to affected cyclones are disclosed. These methods and apparatus involve attacking a cyclone chemically, without the use of explosives, with an energy transfer inhibitor that can interfere with the transmission of energy from the sea surface to the cyclone. The energy transfer inhibitor, if properly chosen and placed in a desired path of the storm, can deny one part of the storm energy from the latent heat of vaporization of water, thereby creating an imbalance in the centrifugal force of the cyclone. The imbalance can reduce the intensity of the cyclone and can be used to steer the storm. Quantifying parameters associated with an affected cyclone enables forecasting the cyclone's energy state, path, intensity, or other related parameters and evaluating possible additional energy transfer inhibitor distribution. | 10-22-2015 |
Charles Richard Bissell, Santa Barbara, CA US
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20140249461 | Portable Spinal Decompression Device - The present invention is a portable device for administering spinal decompression therapy. The device features a compact size and an innovative tension control mechanism to facilitate, in particular, a therapy for imbibition. The use of fabric for a sling and a platform adds comfort features while reducing weight. | 09-04-2014 |
Douglas Eric Bissell, Monros, CT US
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20120076671 | METHOD OF CONVERTING LIQUID RING PUMPS HAVING SEALING LIQUID VENTS - Converting a liquid ring pump which vents sealing liquid (compressant) from the working chamber of the pump to a liquid ring pump having a gas venting system by retasking a selected passage of the liquid ring pump. The passage is selected from a group of passages consisting of ( | 03-29-2012 |
Douglas Eric Bissell, Monroe, CT US
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20110243758 | LIQUID RING PUMP WITH GAS SCAVENGE DEVICE - A liquid ring pump having a channel including a first opening which opens into a first bucket formed by rotor blades. The first opening is located along an arcuate path between a closing edge of an inlet port and a leading edge of a discharge port The inlet port and discharge port are in a port plate of the liquid ring pump. The channel has a second opening which opens into a second bucket formed by rotor blades The second opening is on an arcuate path between a closing edge of the discharge port and a leading edge of the inlet port. A fluid pathway interconnects the first and second openings. At least a portion of the liquid ring pump forming the channel is disposed in a circumferential cylindrical cavity, wherein the cavity is formed from a plurality of axially extending rotor blade ends. | 10-06-2011 |
20110286840 | LIQUID RING PUMP WITH LINER - A liquid ring pump is provided that includes an annular housing having an inner surface forming a housing cavity. The annular housing is filled with an operating fluid during operation of the pump. The operating fluid forms an eccentric liquid ring in the annular housing during operation of the pump. A rotor is disposed in the housing cavity and includes a plurality of rotor blades. A shaft extends into the annular housing into the housing cavity. The plurality of rotor blades extend radially outward from the shaft toward the inner surface of the annular housing. A liner formed from a corrosion resistant material is disposed substantially flush with at least a portion of the annular housing inner surface opposite a plurality of rotor blade ends. | 11-24-2011 |
Henry Martyn Bissell, Oak View, CA US
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20100167608 | Freediving Safety Apparatus - An apparatus for use in the activity of freediving, providing the freediver with increased safety and protection in the event of Shallow Water Blackout, incapacitating hypoxia, or other emergency occurring in or under the water, while providing greater reliability of functioning, and comfort of wearing during the activity of freediving. | 07-01-2010 |
John Bissell, Sacramento, CA US
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20120301933 | PHA-PRODUCING BACTERIA - The present disclosure relates to isolated bacterial strains producing polyhydroxyalkanoate (PHA), microbial consortia including such strains, and cultures of such strains and microbial consortia. In particular, the present disclosure relates to compositions including such strains, microbial consortia, and cultures and methods of use thereof. | 11-29-2012 |
20130245316 | METHODS OF PRODUCING PARA-XYLENE AND TEREPHTHALIC ACID - The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose, starch, sugar) and ethylene in the presence of a catalyst. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF), which may be converted into para-xylene by cycloaddition of ethylene to DMF. Para-xylene can then be oxidized to form terephthalic acid. | 09-19-2013 |
20140100378 | UTILIZING A MULTIPHASE REACTOR FOR THE CONVERSION OF BIOMASS TO PRODUCE SUBSTITUTED FURANS - The present disclosure provides methods to produce substituted furans (e.g., halomethylfurfural, hydroxymethylfurfural, and furfural), by acid-catalyzed conversion of biomass using a gaseous acid in a multiphase reactor, such as a fluidized bed reactor. | 04-10-2014 |
20140350294 | METHODS OF PRODUCING PARA-XYLENE AND TEREPHTHALIC ACID - The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose) and ethylene in the presence of an acid, such as a Lewis acid. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF) and 2-methylfuran, which may be converted into para-xylene and toluene, respectively. In particular, para-xylene can then be oxidized to form terephthalic acid. | 11-27-2014 |
20150148560 | POLYHYDROXYALKANOATE DERIVATIVES, PREPARATION AND USES THEREOF - Provided herein are methods that utilize polyhydroxyalkanoates (PHAs) as a substrate for further conversion to C4 and C5 compounds. Polyhydroxyalkanoates can undergo esterification to yield alkyl hydroxyalkanoates and alkyl alkenoates, which may serve as useful precursors in the production of alkadienes and alkenedioic acids, including for example butadiene and butenedioic acid. | 05-28-2015 |
John A. Bissell, Sacramento, CA US
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20150141695 | METHODS OF PRODUCING PARA-XYLENE AND TEREPHTHALIC ACID - The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose, starch, sugar) and ethylene in the presence of a catalyst. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF), which may be converted into para-xylene by cycloaddition of ethylene to DMF. Para-xylene can then be oxidized to form terephthalic acid. | 05-21-2015 |
Margaret E. Bissell, Winchester, VA US
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20130172415 | TRICLOSAN-FREE ANTIBACTERIAL SOAP - Disclosed herein is an antibacterial cleansing composition. The cleansing composition is free of triclosan and comprises lactic acid/lactate and ethyl alcohol. Lactic acid/lactate is present in the composition in an amount of about 5 weight percent (wt %) to about 15 wt %, based on the total weight of the composition. Ethyl alcohol is present in an amount of about 1 wt % to about 20 wt %, based on the total weight of the composition. The pH of the composition is about 4 to about 5. The triclosan-free cleansing composition according to the invention has broad spectrum antibacterial activity that equals or even surpasses comparable formulations containing triclosan. | 07-04-2013 |
Mark A. Bissell, Pittsford, NY US
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20120141912 | FUEL CELL STACK COMPRISING AN IMPERMEABLE COATING - A fuel cell comprises a substantially contaminant free and contaminant impermeable coating disposed on at least one of a cathode, an anode, a gasket, an insulator plate, a cooler plate, a bipolar plate, a gas diffusion media layer, a polymer electrolyte membrane, an end plate, a tie-bolt, and a gas flow manifold. A process of producing a fuel cell and a fuel cell stack component are also disclosed. | 06-07-2012 |
Michael G. Bissell, Reynoldsburg, OH US
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20080206787 | Process to determine enzyme activity - The present invention provides for various processes for determining enzyme activity. In one embodiment, a process for detecting an enzyme activity includes contacting a blood component with a substrate comprising a cleavage site of the enzyme and a tag moiety to produce a sample comprising a cleavage product having a known mass, and placing the sample in contact with a SELDI sample chip which has surface moieties which bind to the cleavage product. In another embodiment, the process further includes subjecting the SELDI sample chip to SELDI mass spectrometry to identify the cleavage product. The present invention also provides for a kit which includes a SELDI sample chip having surface moieties capable of binding to an enzyme cleavage product. | 08-28-2008 |
Michael W. Bissell, Emeryville, CA US
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20140038294 | SYSTEMS AND METHODS FOR ENGINEERING NUCLEIC ACID CONSTRUCTS USING SCORING TECHNIQUES - Systems and methods are provided for defining a nucleic acid construct for integration at locus L of an organism. Nucleic acid requests are received, each such request specifying a genetic change to L. The request are expanded into component polynucleotides which are then arranged into {AR | 02-06-2014 |
Mina Bissell, Berkeley, CA US
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20140073523 | USE OF GLYCOLYTIC PATHWAYS FOR INHIBITING OR MEASURING ONCOGENIC SIGNALING - Disclosed are methods in which glucose metabolism is correlated to oncogenesis through certain specific pathways; inhibition of certain enzymes is shown to interfere with oncogenic signaling, and measurement of certain enzyme levels is correlated with patient survival. The present methods comprise measuring level of expression of at least one of the enzymes involved in glucose uptake or metabolism, wherein increased expression of the at least one of the enzymes relative to expression in a normal cell correlates with poor prognosis of disease in a patient. Preferably the genes whose expression level is measured include GLUT3, PFKP, GAPDH, ALDOC, LDHA and GFPT2. Also disclosed are embodiments directed towards down-regulating the expression of some genes in glucose uptake and metabolism. | 03-13-2014 |
Mina J. Bissell, Berkeley, CA US
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20090191543 | IDENTIFICATION OF RAC1B AS A MARKER AND MEDIATOR OF METALLOPROTEINASE-INDUCED MALIGNANCY - The present invention provides compositions and methods for detecting MMP-induced malignancies by detecting Rac1b expression. The invention further provides compositions and in vitro and in vivo methods for inhibiting MMP-induced malignant transformation by modulating Rac1b expression and/or function. | 07-30-2009 |
20090274626 | TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY - The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the TACE inhibitor enhances the sensitivity of the cell to the EGFR tyrosine kinase inhibitor. Additionally, methods for treating cancer and methods for identifying TACE inhibitors is also provided. | 11-05-2009 |
20100034828 | Method of Increasing Radiation Sensitivity by Inhibition of Beta One Integrin - A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto. | 02-11-2010 |
20100062000 | Rhamm, a Co-Receptor and Its Interactions with Other Receptors in Cancer Cell Motility and the Identification of Cancer Prognitor Cell Populations - CD44 is an integral hyaluronan receptor that can either promote or inhibit motogenic signaling in tumor cells. Rhamm is a non-integral cell surface (CD168) and intracellular hyaluronan binding protein that promotes cell motility in vitro and whose expression is strongly upregulated in aggressive tumors. The present invention describes compositions and methods for the prognosis and diagnosis of cancer by the detection of CD44/Rhamm complexes. The use of labeled Rhamm-binding agents in culture and in vivo to identify tumorigenic progenitor cells that exhibit an aggressive phenotype characterized by high Rhamm and CD44 expression is further described. Specific methods include using hyaluronan to target imaging or therapeutic agents to these progenitor tumor subsets in breast and likely other cancers. | 03-11-2010 |
20100143382 | MODULATION OF RHAMM (CD168) FOR SELECTIVE ADIPOSE TISSUE DEVELOPMENT - Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described. | 06-10-2010 |
20120094843 | DETECTING AND TREATING BREAST CANCER RESISTANCE TO EGFR INHIBITORS - The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described. | 04-19-2012 |
20120329663 | 14-3-3 sigma as a Biomarker of Basal Cancer - Methods and compositions for using 14-3-3sigma gene and protein as a highly sensitive and specific basal breast cancer biomarker, which when present, correlates with metastasis and poor outcome in independent patient cohorts. Methods and compositions for targeting 14-3-3sigma-regulated actin cytoskeletal interactions, activity and function may benefit patients having the basal-like breast cancer subtype. | 12-27-2012 |
20130157285 | IDENTIFICATION OF INVASIVE AND SLOW-GROWING TUMORIGENIC CELL SUBSETS IN TUMORS - HA-based functional probes and a multiplexed targeting strategy for detection and isolation of invasive subpopulations in breast cancer cell lines. Methods for using HA metabolism for profiling and sorting breast cancer heterogeneity. As such, HA-based functional probes have appropriate targeting capacity and safety profiles for development as imaging and therapeutic agents for following repair and neoplastic disease processes such as breast cancer. | 06-20-2013 |
20130203069 | Dynamic Assay for Maintenance and Disruption of Tissue Level Organization and Architecture - A micropatterning approach, systems and methods that confine cells to a specified geometry combined with an algorithm to quantify changes of cellular distribution over time to measure the ability of different cell types to self-organize relative to each other and detect loss of cellular self-organization. | 08-08-2013 |
20130259807 | CELL CULTURE SCREEN FOR AGENTS THAT CONTROL ADIPOGENESIS AND MYOFIBROBLAST DIFFERENTIATION - Methods are provided for the rapid and robust screening test agents for adipogenic activity. Agents testing positive in the assays are good candidate agents for wrinkle reduction, normalizing skin appearance after reconstructive or cosmetic surgery, e.g., grafted tissue on burn victims, normalizing skin appearance during and after wound healing, and the like. In certain embodiments the methods involve providing mammalian test cells with adipogenic potential wherein said cells are primed for, but withheld from differentiation into adipocytes; contacting the cells with the test agent(s); and screening said test cells for an adipocyte phenotype wherein the presence of a feature characteristic of an adipocyte is an indicator that said test agent is adipogenic. | 10-03-2013 |
20140179616 | PEPTIDES THAT STIMULATE SUBCUTANEOUS ADIPOGENESIS - Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis and uses thereof are provided. | 06-26-2014 |
20150079071 | NON-CATALYTIC DOMAIN TARGETS IN MATRIX METALLOPROTEASE PROTEINS FOR CANCER THERAPIES - The present invention provides compositions and methods for inhibiting MMPs, especially MMP-3, MMP-9 and MMP-14. The invention relates to the field of diagnostic and prognostic methods of human cancers, especially breast cancer and the field of matrix metalloproteases, as targets for diagnostics and therapeutics. | 03-19-2015 |
20150284433 | PEPTIDES THAT STIMULATE SUBCUTANEOUS ADIPOGENESIS - Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis in mammals and uses thereof are provided. | 10-08-2015 |
Pamela Bissell, Ewing, NJ US
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20120059278 | Compound Curette with Layered Anti-Pathogen Protection and Liquid Delivery System - A compound curette for removing tissue samples and delivering liquid and anti-pathogen to the treated area includes a hollow handle that fits a reservoir with a medicated or cosmeceutical solution. A solution is delivered from the reservoir through a channel to a scraping end of the curette by a button activated mechanism. The scraping end of the curette is made of a metal or hard plastic and is covered in anti-pathogen material. The liquid delivery allows placing a medicine or sterilizing solution directly at the locust of the infection. Pathogen inhibition coating provides for a good safeguard to stop or slow bacteria or fungus proliferation. The method of scraping debris and medication delivery is particularly useful for the treatment of onychomycosis, commonly referred to as a fungus infection of the toenail. Main portions of the curette could be detachable, allowing for the easy reservoir replacement and for the use of multiple scraping utensils. Similarly, the device could be manufactured for a single use when all parts are molded together. | 03-08-2012 |
Richard L. Bissell, Rio Rancho, NM US
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20100269681 | Pointing Device Inertial Isolation and Alignment Mounting System - An inertial isolation and alignment system for a sensitive component or apparatus affixed to a mortar barrel comprising a barrel clamp assembly which supports two parallel bearing rail followers and pointing device cage assembly which supports two parallel linear bearing rails. The bearing rail followers and linear bearing rails form a simple sliding contact linear motion bearing system. The bearing rail followers on the barrel clamp assembly allow the cage assembly to slide freely along the length of the linear bearing rails. During firing, the travel vector is decoupled from the cage assembly by the bearing rail followers as they move with the barrel along the linear bearing rails leaving the cage assembly suspended in inertial space. The cage assembly then accelerates under the force of gravity over the distance of the displaced travel of the bearing rail followers back to its rest position landing on dampers, each on a linear bearing rail. | 10-28-2010 |
Steven R. Bissell, Andover, CT US
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20090094832 | Heat treating apparatus and method of using same - An apparatus and method for heat treating the welded area of a repaired gas turbine engine component uses first and second heating elements. The heating elements each include an insulating tube supported by a support rod and wrapped with a conducing wire. One of the heating elements is sized to fit inside a recess in the gas turbine engine component, adjacent to the welded area, while the second heating element is placed outside the recess, but also adjacent to the welded area, thereby heating the welded area from two sides. | 04-16-2009 |