Patent application number | Description | Published |
20090001121 | Surgical staple having an expandable portion - A surgical staple including features which can reduce bleeding from soft tissue. In various embodiments, the surgical staple can include at least one deformable member which can puncture a hole in soft tissue as it is inserted therethrough. The deformable member can include a material thereon, or can be comprised of a material, which can expand and substantially fill the puncture hole in the soft tissue. In various embodiments, at least a portion of the deformable member can be coated with a hydrophilic material which can expand when exposed to water, or other bodily fluids, and apply a compression force to the perimeter of the puncture hole. Such a compression force can reduce bleeding from the puncture hole and thereby reduce any potential complications resulting therefrom. | 01-01-2009 |
20090131938 | DERIVATIZED TERTIARY AMINES AND USES THEREOF - The invention relates to a tertiary amine intermediate represented by the following formula, and electrophilic monomers derived therefrom. The invention also relates to adhesives or sealants derived from such electrophilic moieties. | 05-21-2009 |
20090292027 | COMPOSITIONS FOR THE TREATMENT OF SIGNS OF AGING - The present invention features a method of treating at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, and reducing the appearance of wrinkles or cellulite on the skin, by administering to skin in need of such treatment a composition comprising at least one compound of the formula I or formula II: | 11-26-2009 |
20090297469 | Cyanoacrylate Monomer Formulation Containing Diiodomethyl-p-tolylsulfone and 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether - A polymerizable antimicrobial formulation for forming a wound closure adhesive comprising cyanoacrylate monomer, diiodomethyl-p-tolylsulfone and a halogenated hydroxyl diphenyl ether; and a method for closing the approximated edges of a wound with a polymeric film that substantially inhibits the growth of microorganisms, where the polymeric film is formed by use of the polymerizable antimicrobial formulation. | 12-03-2009 |
20100196522 | COMPOSITIONS CONTAINING AMINES AND USE THEREOF - The present invention features compositions comprising at least one compound of the formula I or formula II: | 08-05-2010 |
20100249698 | CONTROLLED EXOTHERM OF CYANOACRYLATE FORMULATIONS - The present invention is directed to curable cyanoacrylate-based formulation containing a multi-functional amine initiator. A dual function amine, particularly Quadrol, provides a highly desirable balance of maximum cure temperature and setting time of cure with the same higher viscosity, non-running cyanoacrylate formulation. The present invention is also directed to systems that utilize the inventive formulations and methods for use of such formulations. | 09-30-2010 |
20110091586 | COMPOSITIONS CONTAINING AMINES AND USE THEREOF - The present invention features compositions comprising at least one compound of the formula I or formula II: | 04-21-2011 |
20110192882 | SURGICAL STAPLE HAVING AN EXPANDABLE PORTION - A surgical staple including features which can reduce bleeding from soft tissue. In various embodiments, the surgical staple can include at least one deformable member which can puncture a hole in soft tissue as it is inserted therethrough. The deformable member can include a material thereon, or can be comprised of a material, which can expand and substantially fill the puncture hole in the soft tissue. In various embodiments, at least a portion of the deformable member can be coated with a hydrophilic material which can expand when exposed to water, or other bodily fluids, and apply a compression force to the perimeter of the puncture hole. Such a compression force can reduce bleeding from the puncture hole and thereby reduce any potential complications resulting therefrom. | 08-11-2011 |
20120288530 | TISSUE SEALANTS FROM PLASMA DERIVED PROTEINS - The present invention is directed in one embodiment to a tissue adhesive or sealant composition comprising an electrophilic group containing cross-linking compound having a linker moiety of a diglycolic acid, a water soluble core moiety and an electrophilic group that is covalently bonded to the diglycolic acid linker moiety and a nucleophilic group containing protein. In other embodiments, the present invention is directed to a delivery device or a medical device on which the composition has been applied or incorporated therein. The present invention is also directed to a method for sealing tissue using the tissue adhesive or sealant composition. | 11-15-2012 |
20140220136 | SYSTEM AND METHOD FOR DELIVERING PROTEASE INHIBITORS - The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“TA”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation. Next, the formulation along with fibrinogen and thrombin is applied to a wound site where an outer surface of the polymer microsphere degrades in a proteolytic environment to expose and release the incorporated protease inhibitor to the surrounding hydrogel or sealant or clot matrix at the wound site. | 08-07-2014 |