Bessis
Alain Bessis, Paris FR
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20090013421 | Genomic DNA fragments containing regulatory and coding sequences for the B2-subunit of the neuronal nicotinic acetylcholine receptor and transgenic animals made using these fragments or mutated fragments - Several genes encoding subunits of the neuronal nicotinic acetylcholine receptors have been cloned and regulatory elements involved in the transcription of the ∝:2 and ∝:7-subunit genes have been described. Yet, the detailed mechanisms governing the neuron-specific transcription and the spatio-temporal expression pattern of these genes remain largely uninvestigated. The β2-subunit is the most widely expressed neuronal nicotinic receptors subunit in the nervous system. We have studied the structural and regulatory properties of the 5′ sequence of this gene. A fragment of 1163 bp of upstream sequence is sufficient to drive the cell-specific transcription of a reporter gene in both transient transfection assays and in transgenic mice. Deletion analysis and site-directed mutagenesis of this promoter reveal two negative and one positive element. The positively acting sequence includes one functional E-box. One of the repressor elements is located in the transcribed region and is the NRSE/RE1 sequence already described in promoters of neuronal genes. | 01-08-2009 |
Anne-Sophie Bessis, Ferney-Voltaire FR
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20090124625 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS - The present invention relates to novel compounds of formula (I) wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors. | 05-14-2009 |
20110112143 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS - The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R | 05-12-2011 |
20120022108 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS - The present invention relates to new compounds of formula (I) wherein A, B, P, Q, W, R | 01-26-2012 |
20120277237 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS - The present invention relates to novel compounds of formula I wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors. | 11-01-2012 |
Natacha Bessis, Paris FR
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20110033567 | Preparation Comprising Mycobacterium Bovis BCG Killed by Extended Freeze Drying (EFD) for Preventing or Treating Rheumatoid Arthritis - Preparation comprising | 02-10-2011 |
Thierry Bessis, Naperville, IL US
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20110035413 | DIAMETER BUS COMMUNICATIONS BETWEEN PROCESSING NODES OF A NETWORK ELEMENT - A Diameter bus between Diameter processing nodes of the same network element is disclosed herein. The Diameter bus includes a data structure that is used to transfer Diameter messages between the processing nodes. In doing so, the data structure avoids the overhead associated with SCTP, TCP, Ethernet, and/or IP encoding that is required by the Diameter base protocol. To ensure that the Diameter processing nodes operate as intended, the Diameter bus also includes a simplified Diameter transport structure such that Capabilities Exchange messaging between Diameter processing nodes is maintained as required by the Diameter base protocol. However, the simplified Diameter transport structure forgoes other functionality associated with the Diameter base protocol, such as the Device Watchdog messaging. By eliminating certain features of the Diameter base protocol as well as the SCTP/TCP/IP encoding and decoding associated with Diameter communications, processing performance of the network element can be substantially improved. | 02-10-2011 |
Thierry C. Bessis, Naperville, IL US
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20100302944 | System & method for load spreading - Various method and apparatus are provided directed to load allocation. In one embodiment, a distributor distributes a load to one of a plurality of peer nodes, each peer node having associated thereto a corresponding scalar based on a load factor value, the scalar of the one peer node satisfying a load management condition. The corresponding scalar of the plurality of peer nodes may be tested in a sequentially order until the load management condition is satisfied by the scalar of the one peer nodes. Testing may include threshold testing and begin with the scalar of a last remote peer node to which a most recent prior load was distributed. When the load management condition is satisfied by a scalar, it is decremented based on the load factor value, which may approximate a first number divided by the number of peer nodes in the plurality. | 12-02-2010 |
20120180119 | Session Initiation Protocol (SIP) Firewall For IP Multimedia Subsystem (IMS) Core - A SIP firewall defends an IMS network against SIP registration-based DoS/DDoS attacks by issuing fake authentication challenges when suspiciously high registration traffic is present. The fake authentication challenges include a predictive nonce that is to be used in the challenge response, thus forcing users to be state-aware and to issue the SIP registration requests from valid IP address in order to successfully respond to the fake authentication challenges. Upon confirming an association between the challenge response and the fake authentication challenges, the firewall opens a registration window to a protected node of the core network. In such manner, the firewall opens a registration window to (unauthenticated) legitimate users while stopping DDoS mode of registrations (or at least making them extremely difficult and costly) without impacting or involving the protected node. | 07-12-2012 |