Patent application number | Description | Published |
20080220102 | Solubilsation Products of an Active Ingredient Extract - The invention relates to a solubilizate of a phytoextract, which contains a physiological or pharmaceutical active ingredient, which solubilizate contains about 10% by weight to about 30% by weight of the phytoextract, about 4% by weight to about 35% by weight of water, which can be deionised, demineralised or distilled once or many times, and from about 55% by weight to about 75% by weight of an emulsifier having an HLB-value that ranges between 9-16, based on the solubilizate, which is equal to 100% by weight. | 09-11-2008 |
20090048334 | Sodium ascorbate solubilisate - The invention relates to a solubilisate consisting of an aqueous solution of the alkali salts and/or alkaline-earth salts of ascorbic acid for foodstuffs, cosmetics and or similar and consisting of an emulsifier with an HLB value of between 9 and 18, for example a polysorbate, which also comprises one or more mid-chain triglycerides and/or one or more tocopherols. | 02-19-2009 |
20090306210 | Solubilizates of Preservatives and Method for Producing the Same - Described is a solubilisate of a preservative containing an aliphatic and/or aromatic acid such as sorbic acid and/or benzoic acid that is free of stabilizing agents, as well as one or more emulsifiers with an HLB value between 9 and 18 with a concentration of about 50% and about 95% emulsifier with regard to the total quantity of the solubilisate, and a procedure for the production of such a solubilisate. | 12-10-2009 |
20110184054 | Alpha-lipoic acid concentrate - A water-free concentrate, consisting of ubiquinone Q | 07-28-2011 |
20110293678 | Micellarly integrated oxidation protection for natural dyes - In order to formulate natural dyes, which are insoluble or sparingly soluble in water, in such a way that the dye is protected against oxidation, also and in particular after being incorporated into the end product with dilution, and which as a replacement for azo dyes in a beverage result in a solution which is clear to the human eye, the invention provides a solubilizate and a method for preparing a solubilizate. The solubilizate contains at least one natural dye that is insoluble or sparingly soluble in water, at least one emulsifier having an HLB value of 8 to 19, and at least two antioxidants. The dye and the antioxidants are present enclosed together in micelles. | 12-01-2011 |
Patent application number | Description | Published |
20090047360 | Bone morphogenic protein binding peptide - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 02-19-2009 |
20100183719 | Surgical Applications for BMP Binding Protein - The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired. | 07-22-2010 |
20100239634 | COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION - A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided. | 09-23-2010 |
20110054408 | DELIVERY SYSTEMS, DEVICES, TOOLS, AND METHODS OF USE - A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering. | 03-03-2011 |
20110070312 | BONE MATRIX COMPOSITIONS AND METHODS - Methods for demineralizing bone are provided. In some embodiments, the methods include demineralizing the bone in a demineralization medium and separating the bone into particles during demineralization. In other embodiments, the methods include placing the bone in a demineralization medium and treating the demineralization medium while the bone is in the demineralization medium to optimize the demineralization process. | 03-24-2011 |
20110130836 | Compositions and Methods for Use of Scar Tissue in Repair of Weight Bearing Surfaces - Compositions and methods are provided for weight bearing surface, i.e., intervertebral disc (“disc”), between spinous processes and articular cartilage, repair. Compositions include fibrosis inducing agents for facilitating fibrosis in or on the site in need of repair in order to form fibrotic connective tissue. In addition, methods are provided for distracting the appropriate disc space during treatment of a disc in need of repair, and in particular treatment of the disc in need of repair with a fibrosis inducing agent. Further, methods and compositions are provided for inducing or forming fibrotic tissue at a bone surface having damaged cartilage or in a joint in need of repair. | 06-02-2011 |
20120184490 | ENHANCEMENT OF BMP RETENTION - The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical co | 07-19-2012 |
20130095075 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
20130095139 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
20130303449 | SURGICAL APPLICATIONS FOR BMP BINDING PROTEIN - The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired. | 11-14-2013 |
20140277570 | BONE GROWTH PROMOTION SYSTEMS AND METHODS - This disclosure describes systems and methods for providing a novel delivery system for implantation in a patient. Further, this disclosure describes a delivery system including a carrier that is made of at least one monolithic bone tissue for retaining one or more substances. | 09-18-2014 |
20150056700 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 02-26-2015 |