Patent application number | Description | Published |
20120040451 | MOLECULES ABLE TO MODULATE THE EXPRESSION OF AT LEAST A GENE INVOLVED IN DEGRADATIVE PATHWAYS AND USES THEREOF - A molecule being able to modulate the expression of at least a gene involved in degradative pathways so to enhance the cellular degradative pathways and prevent or antagonize the accumulation of toxic compounds in a cell and acting on a CLEAR element. Preferred molecules are: the TFEB protein, synthetic or biotechnological functional derivative thereof; chimeric molecule comprising the TFEB protein, synthetic or biotechnological functional derivative thereof; modulator of the TFEB protein activity and/or expression level. The molecule may be used in the treatment of neurodegenerative and/or lysosomal storage disorders. | 02-16-2012 |
20130302308 | THERAPEUTIC STRATEGIES TO TREAT CNS PATHOLOGY IN MUCOPOLYSACCHARIDOSES - The invention refers to nucleotide sequence encoding for a chimeric sulfatase, viral vectors expressing such sequences for gene therapy and pharmaceutical uses of the chimeric expressed protein. The invention is particularly applied in the therapy of mucopolysaccharidosis, preferably type IIIA. | 11-14-2013 |
20140038897 | TFEB VARIANTS AND USES THEREOF - The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases. | 02-06-2014 |
20140038920 | TFEB PHOSPHORYLATION INHIBITORS AND USES THEREOF - The invention refers to TFEB phosphorylation inhibitors. Such molecules have a therapeutic applicability in all disorders that need induction of the cell authophagic/lysosomal system, such as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases. | 02-06-2014 |
Patent application number | Description | Published |
20110108187 | PROCESS AND APPARATUS FOR ASSEMBLING TYRES - In an assembly station, a carcass sleeve and an outer sleeve manufactured along respective building lines are mutually coupled. Integrated into the assembly station are engagement devices that can be alternatively-coupled to an auxiliary drum carrying an outer sleeve and to a building drum carrying a carcass sleeve. The building drum is engaged on the assembly station before removal of the auxiliary drum. A grip unit picks up the outer sleeve from the auxiliary drum associated with the engagement devices in order to position it around the carcass sleeve carried by the building drum. | 05-12-2011 |
20120255667 | PROCESS AND APPARATUS FOR BUILDING TYRES FOR VEHICLE WHEELS - A process and an apparatus for building tyres for vehicle wheels includes assembling at least one tyre component through laying of strip-like elements disposed circumferentially close to each other on a deposition surface radially external to the forming drum, wherein laying of each strip-like element includes: radially moving the strip-like element close to the deposition surface; locking a central portion of the strip-like element against the deposition surface; and pulling the strip-like element in opposite directions starting from the central portion toward the opposite ends thereof, while the central portion is maintained in a locked condition against the deposition surface, so as to progressively lay down the strip-like element against the deposition surface. | 10-11-2012 |
20130078058 | METHOD OF CONTROLLING THE MANAGEMENT OF FORMING DRUMS IN BUILDING TYRES FOR VEHICLE WHEELS AND PLANT FOR PRODUCTION OF TYRES FOR VEHICLE WHEELS - A method of controlling the management of forming drums in building tyres for vehicle wheels and a plant for production of tyres for vehicle wheels, wherein the plant includes at least one building line including at least one assembly of “m” work stations, each adapted to form at least one portion of a component of the tyre; devices for feeding and picking up “n” forming drums, one at a time, to and from the building line at each time interval equal to a cycle time; transfer devices for respectively bringing and moving apart “m” distinct forming drums to and from “m” distinct work stations of the assembly, wherein each of the “m” work stations respectively receives and releases a forming drum at each time interval equal to a multiple of “m” of said cycle time, wherein “m” is greater than or equal to 2 and “n” is greater than or equal to “m”. | 03-28-2013 |
20130103181 | METHOD FOR CONTROLLING THE DEPOSITION OF SEMIFINISHED ELEMENTS FOR TYRE PRODUCTION - A method of controlling the deposition of semifinished elements for tyre production, includes: sending a first radiation onto one tyre being processed, consisting of one forming support with at least one portion of the tyre component laid on the support, the tyre component being at least partly formed of a plurality of semifinished elements defining a radially external layer of the tyre being processed; receiving a first reflected radiation from a radially external surface of the tyre being processed; determining, as a function of the reflected radiation, parameters representative of the thickness of the layer; comparing the parameters with reference values; and generating an alarm signal as a function of the comparison. | 04-25-2013 |
20140288689 | METHOD FOR CONTROLLING THE MOVEMENT OF BUILDING MEMBERS OF A TYRE IN A PROCESS FOR MANUFACTURING TYRES FOR VEHICLE WHEELS - Method and apparatus for controlling the movement of building members of a tyre in a process for manufacturing tyres for vehicle wheels includes: providing a first device of a first electromagnetic radiation on a first tyre building member; detecting, during a movement of the first building member, a first image in which the first electromagnetic radiation defines a trajectory followed, in the movement, by the first emitter device; carrying out a first comparison between the first image and one or more first reference data; and generating a first notification signal as a function of the first comparison. | 09-25-2014 |
20140341460 | METHOD FOR CONTROLLING THE DEPOSITION OF ELEMENTARY SEMIFINISHED PRODUCTS IN A PROCESS FOR BUILDING TYRES FOR VEHICLE WHEELS - A method and apparatus for controlling the deposition of elementary semifinished products in a process for building tyres for vehicle wheels includes: driving in rotation, around a rotation axis, at a rotation speed between about π/8 raft and about 6 π rad/s, a tyre being processed which tyre has a radially external surface including one or more elementary semifinished products; sending a first electromagnetic radiation to the radially external surface, the latter generating a corresponding first reflected radiation; detecting, through a first detecting device, at least one first image representative of the first reflected radiation; controlling the first detecting device in such a manner that a first exposure time for detecting the at least one first image is included between about 0.1 s and about 10 s; carrying out a first comparison between the at least one first image and one or more reference data; and generating a first notification signal as a function of the first comparison. | 11-20-2014 |
20140374008 | Process and Apparatus for Manufacturing Tyres for Vehicle Wheels - Building the carcass structure of tyres for vehicle wheels includes associating, at each end edge of a carcass ply, at least one respective annular reinforcement structure formed by depositing along a circumferential direction a plurality of reinforcement elements having a first length. Such elements are cut to size from a reinforced continuous band-like element fed to a cutting group arranged at a first operative position adapted to allow a barycentric grip of the reinforcement elements. The cutting group can translate along a feeding direction of the band-like element to a second operative position for cutting to size a plurality of second reinforcement elements having a second length different from the first length. The second operative position is defined on the basis of the second length, so as to have a barycentric grip of the second reinforcement elements too. | 12-25-2014 |