Patent application number | Description | Published |
20110052559 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY - The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B. | 03-03-2011 |
20130078230 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINOGMYELINASE DEFICIENCY - The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B. | 03-28-2013 |
20130078231 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINOGMYELINASE DEFICIENCY - The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B. | 03-28-2013 |
20140335070 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY - The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B. | 11-13-2014 |
20160120957 | DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY - The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B. | 05-05-2016 |
Patent application number | Description | Published |
20100251565 | Training Footwear - An article of footwear includes a sole having a forefoot portion, a heel portion and an outsole having a bottom surface including a primary ground contacting surface. The bottom surface of the outsole includes a forefoot bulge and a heel bulge which provide the footwear with controlled instability for providing dynamic conditioning of the wearer's muscles during the gait cycle. | 10-07-2010 |
20100251567 | Training Footwear - Articles of footwear are disclosed. In one embodiment, an article of footwear comprises a sole having a forefoot portion and a heel portion. The sole comprises a midsole, an intermediate sole, and a ground contacting surface. At least a portion of the intermediate sole extends from the midsole such that a forefoot bulge substantially covers the forefoot portion of the ground contacting surface and a heel bulge substantially covers the heel portion of the ground contacting surface. | 10-07-2010 |
20100281711 | Article of Footwear Having a Support Structure - Articles of footwear having support structures are disclosed. An article of footwear comprises: a midsole having a plurality of cavities formed therein; and a flexible cage member disposed on the midsole and extending across at least one of the plurality of cavities. The flexible cage member includes a plurality of support arms disposed on the midsole; and a linking member extending across at least one of the cavities and connecting at least two of the support arms. | 11-11-2010 |
20130199054 | Training Footwear - An article of footwear includes a sole having a forefoot portion, a heel portion and an outsole having a bottom surface including a primary ground contacting surface. The bottom surface of the outsole includes a forefoot bulge and a heel bulge which provide the footwear with controlled instability for providing dynamic conditioning of the wearer's muscles during the gait cycle. | 08-08-2013 |
20140215849 | Training Footwear - An article of footwear includes a sole having a forefoot portion, a heel portion and an outsole having a bottom surface including a primary ground contacting surface. The bottom surface of the outsole includes a forefoot bulge and a heel bulge which provide the footwear with controlled instability for providing dynamic conditioning of the wearer's muscles during the gait cycle. | 08-07-2014 |
Patent application number | Description | Published |
20080251141 | BACKFLOW PREVENTION FOR HIGH PRESSURE GRADIENT SYSTEMS - Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance. | 10-16-2008 |
20090211978 | Passive column pre-heater with sample band spreading reduction feature - Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube. | 08-27-2009 |
20120103075 | Automated Dilution For Liquid Chromatography - Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced. | 05-03-2012 |
20120285223 | METHOD FOR DETERMINING EQUIVALENT THERMAL CONDITIONS BETWEEN LIQUID CHROMATOGRAPHY SYSTEMS - Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be more readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained. | 11-15-2012 |
20130206666 | Process For Preparing Liquid Mixtures Of Known pH And Salt Concentration - A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more salts, and one or more solvents, and the method comprises the steps of: i) calculating pH and/or salt concentration at a particular time t from a user-determined gradient function; and ii) based on the values obtained in step (i), calculating percent acid, percent base, percent salt and percent solvent in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided. | 08-15-2013 |
20130228513 | GRADIENT SEPARATION METHOD TRANSFER FOR LIQUID CHROMATOGRAPHY SYSTEMS - Described is a method of transferring a gradient separation method to a liquid chromatography system. A value of a delivered gradient slope for a gradient separation method performed on a first liquid chromatography system is determined based on a value of a programmed gradient slope for the gradient separation method and a predetermined relationship between delivered gradient slope and programmed gradient slope for the first liquid chromatography system. The gradient separation method is performed on a second liquid chromatography system using a delivered gradient slope having a value equal to the value of the delivered gradient slope determined for the first liquid chromatography system | 09-05-2013 |
20150076068 | ACTIVE INLET TEMPERATURE CONTROL FOR ADJUSTMENT OF RETENTION IN A LIQUID CHROMATOGRAPHY SYSTEM - Described are methods in which the retention times of a chromatographic column are adjusted through the control of the temperature of a mobile phase at the inlet to the chromatographic column. The temperature of the mobile phase at the inlet is different from the temperature of the chromatographic column. Adjustment of the temperature of the mobile phase at the inlet can be used as part of a method to transfer a chromatographic method from one liquid chromatography system to another liquid chromatography system. The method can alternatively be adapted for trapping a sample at the head of a chromatographic column to reduce the amount of band broadening of the sample from the sample injector of a liquid chromatography system. A gradient elution can then be performed to cause the concentrated volume of the analyte in the sample to elute in a tight band, resulting in improved measurement sensitivity. | 03-19-2015 |
20150125963 | TECHNIQUES FOR ENSURING IDENTIFICATION AND CHAIN OF CUSTODY INFORMATION OF DRIED SAMPLES - Techniques for use with dried sample portions include a device having sample areas, identification areas and detachable portions. Each sample area includes one of the dried sample portions of the sample. Each identification area includes information stored therein which identifies the sample from which the dried sample portions stored on the sample areas of the device are obtained. Each detachable portion includes one of the sample areas and includes one of the identification areas. Also described is a method for processing dried sample portions of a sample. A card is received that includes a plurality of detachable portions. Each detachable portion includes a sample area with a dried sample portion and an identification area including information that identifies the sample. A first detachable portion is detached to process a dried sample portion included in the first detachable portion. | 05-07-2015 |
20150129494 | METHOD AND AN APPARATUS FOR CONTROLLING FLUID FLOWING THROUGH A CHROMATOGRAPHIC SYSTEM - A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid. | 05-14-2015 |
20150276687 | METHOD FOR DETERMINING EQUIVALENT THERMAL CONDITIONS BETWEEN LIQUID CHROMATOGRAPHY SYSTEMS - Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems and a sample for performing the method. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained. | 10-01-2015 |
20160054275 | METHOD FOR EXTENDING THE DYNAMIC RANGE OF ABSORBANCE DETECTORS - The invention generally provides methods for improving the dynamic range of an absorbance detector and absorbance detectors having improved dynamic range. In an exemplary embodiment, the method includes receiving calibration data for a plurality of samples, the calibration data comprising an absorbance for a concentration of each of the samples, calculating a contribution of stray light to the calibration data, and correcting subsequent data by removing the contribution of stray light. | 02-25-2016 |
Patent application number | Description | Published |
20090264914 | METHOD AND APPARATUS FOR SEALING AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - An expandable spherical structure for deployment in a blood vessel or other body lumen, comprising:
| 10-22-2009 |
20100076365 | METHOD AND APPARATUS FOR ACCESSING THE WALL OF A VASCULAR STRUCTURE OR OTHER BODY LUMEN WHILE SIMULTANEOUSLY PROVIDING ZONE ISOLATION AND FLUID BYPASS CAPABILITY - Apparatus and method for accessing the wall of a body lumen while simultaneously providing zone isolation and fluid bypass capability, the apparatus comprising:
| 03-25-2010 |
20100094327 | METHOD AND APPARATUS FOR STRAIGHTENING AND FLATTENING THE SIDE WALL OF A BODY LUMEN OR BODY CAVITY SO AS TO PROVIDE THREE DIMENSIONAL EXPOSURE OF A LESION OR ABNORMALITY WITHIN THE BODY LUMEN OR BODY CAVITY, AND/OR FOR STABILIZING AN INSTRUMENT RELATIVE TO THE SAME - Apparatus for straightening and flattening a side wall of a body lumen or body cavity so as to provide three dimensional exposure of an abnormality within the body lumen, and simultaneously providing for the stabilization of the working end of an endoscope or surgical tool, the apparatus comprising a deployable hoop expander comprising a structure defining a volume and being configured so as to be transitionable between a reduced cross-sectional configuration for easy insertion into a body lumen and an expanded cross-sectional configuration for engaging, straightening and flattening the side wall of the body lumen, whereby to provide three dimensional exposure of the abnormality within the body lumen, the deployable hoop expander being configured for simultaneously providing for the docking of the end of the endoscope or other instrument so as to stabilize the same for endoscopic viewing and/or therapy. | 04-15-2010 |
20100268260 | Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen - An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising:
| 10-21-2010 |
20120289988 | METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE STILL MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising:
| 11-15-2012 |
20150032145 | METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE STILL MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising:
| 01-29-2015 |
20150216534 | METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE STILL MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising:
| 08-06-2015 |
Patent application number | Description | Published |
20100152891 | LIQUID HANDLING SYSTEM WITH ELECTRONIC INFORMATION STORAGE - An electronic storage device is coupled with a container capable of holding liquid for electronically storing information relating to the liquid stored in the container. The system can be configured with an antenna, for storing information to and reading information from the electronic storage device. A microprocessor-based controller, coupled with the antenna, may be employed for controlling processing of the liquid based on information read from the electronic storage device by the antenna. A connector of a secure reader system having a reader is provided to physically couple to a container having an information storing mechanism, for periodically reading information from an information storing mechanism. The connector may draw material from the container simultaneous with the reading. | 06-17-2010 |
20120186671 | LIQUID HANDLING SYSTEM WITH ELECTRONIC INFORMATION STORAGE - An electronic storage device is coupled with a container capable of holding liquid for electronically storing information relating to the liquid stored in the container. The system can be configured with an antenna, for storing information to and reading information from the electronic storage device. A microprocessor-based controller, coupled with the antenna, may be employed for controlling processing of the liquid based on information read from the electronic storage device by the antenna. A connector of a secure reader system having a reader is provided to physically couple to a container having an information storing mechanism, for periodically reading information from an information storing mechanism. The connector may draw material from the container simultaneous with the reading. | 07-26-2012 |
20150032253 | LIQUID HANDLING SYSTEM WITH ELECTRONIC INFORMATION STORAGE - An electronic storage device is coupled with a container capable of holding liquid for electronically storing information relating to the liquid stored in the container. The system can be configured with an antenna, for storing information to and reading information from the electronic storage device. A microprocessor-based controller, coupled with the antenna, may be employed for controlling processing of the liquid based on information read from the electronic storage device by the antenna. A connector of a secure reader system having a reader is provided to physically couple to a container having an information storing mechanism, for periodically reading information from an information storing mechanism. The connector may draw material from the container simultaneous with the reading. | 01-29-2015 |