An, US
Andrew An, Evanston, IL US
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20150066000 | Surgical Tool With Integrated Sensor - An instrumented surgical tool and associated systems and methods for performing surgical procedures such as tissue dissection or ligation using the instrumented surgical tool are described. In particular, a surgical tool operatively connected to a sensor used to detect a structural artifact such as the presence and characteristics of a blood vessel and to evaluate the safe use of the surgical tool within a surgical field is described. | 03-05-2015 |
Anna An, Portland, OR US
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20120300698 | EXCHANGING PRESENCE INFORMATION IN A COMMUNICATIONS NETWORK - The disclosure relates to decentralized presence management within a communications system performed at a user device. An embodiment of the disclosure comprises selectively updating at least one frequency at which the user device transmits presence update messages to one or more other user devices that belong to a contact group associated with the user device. The embodiment further comprises transmitting one or more presence update messages in accordance with the selectively updated frequency. Another embodiment of the disclosure comprises obtaining a subset of contacts of a subscriber operating the user device that form a presence update group. The embodiment further comprises identifying a plurality of sub-groups within the presence update group based on priorities of the subset of contacts. The embodiment further comprises transmitting one or more presence update messages to less than all of the identified plurality of sub-groups. | 11-29-2012 |
Bo An, Amherst, MA US
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20090282415 | Method and Apparatus for Negotiation Management in Data Processing Systems - Techniques are disclosed for optimizing schedules used in implementing plans for performing tasks in data processing systems. For example, an automated method of negotiating for resources in a data processing system, wherein the data processing system comprises multiple sites, comprises a negotiation management component of a computer system at a given one of the sites performing the following steps. One or more tasks from at least one source of one or more plans are obtained. Each plan is annotated with one or more needed resources and one or more potential resource providers at one or more sites in the data processing system. An optimized resource negotiation schedule based on the one or more obtained tasks is computed. The schedule comprises an order in which resources are negotiated. In accordance with the optimized resource negotiation schedule, a request for each needed resource is sent to the one or more potential resource providers such that a negotiation process is performed between the negotiation management component and at least one of the potential resource providers. | 11-12-2009 |
Bob (robert) An, Bridgewater, NJ US
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20080249020 | Human Growth Hormone Treatment Methods - New methods for developing dosing formulas that allow the determination of appropriate dosage regimens for human growth hormone (hGH) compounds; methods for using such formulas to calculate individualized hGH compound dosage regimens; methods for treatment of hGH-responsive syndromes in patients using such determined regimens; systems, devices, and computer-readable media comprising instructions for receiving predictive value information and for generating dosage regimens and/or dosing formulas; and other related systems and methods are provided by the invention described herein. | 10-09-2008 |
Chae An, Northville, MI US
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20130215637 | HIGHLIGHTING INTERIOR AUTOMOTIVE COMPONENTS BY REFLECTING LIGHT FROM HIDDEN LIGHT PIPE ON TO A CONTOURED REFLECTIVE SURFACE - An illuminating apparatus and method for an interior passenger compartment of a vehicle including, in combination, a panel, a manual operation element mounted to the panel, and a hidden light mounted behind the panel providing indirect light directed along a path extending downwardly across a visible surface of the panel through an aperture in the panel. A bezel can be associated with the manual operation element. The bezel can define an edge with a reflective surface. The bezel is located on the visible surface of the panel within the path of indirect light. The edge reflects indirect light from the hidden light pipe to be visible to occupants of the passenger compartment of the vehicle. | 08-22-2013 |
Chae H. An, Northville, MI US
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20090174221 | Locating Structure For An Instrument Panel Assembly Of A Motor Vehicle - An instrument panel assembly for a motor vehicle includes a first component, a second component and a frame. The first component has a first aperture. The second component has a second aperture. The frame has a main wall. The frame includes a generally cylindrical boss extending outwardly from the main wall. The boss has an outer surface. The boss has a bore aligned with the first aperture of the first component to receive a fastener therethrough to secure the first component to the frame. The boss extends through the second aperture of the second component such that the outer surface locates the second component relative to the frame along a plane generally orthogonal to a longitudinal axis of the boss. The second component is disposed between the first component and the frame so as to be constrained along the longitudinal axis of the boss. | 07-09-2009 |
Chae Hon An, Northville, MI US
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20090156113 | Motor Vehicle Instrument Panel Assembly Having A Conduit With A Gasket Support Lip - An instrument panel assembly for a motor vehicle includes a panel member, a first conduit, a second conduit and a gasket disposed between the first and second conduit. The panel member has a vent for directing air toward a window in the vehicle. The first conduit has a first end coupled to a bottom side of the panel member and providing air to the vent. The first conduit has a second end with a peripheral wall forming an inlet. The second conduit has an outlet that provides air to the inlet of the first conduit. The second conduit has a flange that extends outwardly from the outlet and includes a support surface that supports a gasket for sealing an interface between the outlet of the second conduit and the inlet of tie first conduit. The second conduit has a lip that extends outwardly from the support surface of the flange and supports the gasket to prevent deformation of the gasket during assembly of the first conduit and second conduit. | 06-18-2009 |
Chihui An, Philadelphia, PA US
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20150344462 | IRCINIASTATIN ANALOGUES - The present invention is directed to irciniastatin analogues. Uses of these analogues also described. | 12-03-2015 |
Chong Pyung An, Painted Post, NY US
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20080200088 | Method for reducing interference fringes in a display device - A method of minimizing the formation of interference fringes in an OLED display device is disclosed comprising sealing the upper and lower glass substrates comprising the display device to one another within an enclosure wherein a pressure of the atmosphere within the enclosure is greater than the pressure of the atmosphere outside the enclosure. | 08-21-2008 |
20090324830 | TIN PHOSPHATE BARRIER FILM, METHOD, AND APPARATUS - A method is disclosed for inhibiting oxygen and moisture penetration of a device comprising the steps of depositing a tin phosphate low liquidus temperature (LLT) inorganic material on at least a portion of the device to create a deposited tin phosphate LLT material, and heat treating the deposited LLT material in a substantially oxygen and moisture free environment to form a hermetic seal; wherein the step of depositing the LLT material comprises the use of a resistive heating element comprising tungsten. An organic electronic device is also disclosed comprising a substrate plate, at least one electronic or optoelectronic layer, and a tin phosphate LLT barrier layer, wherein the electronic or optoelectronic layer is hermetically sealed between the tin phosphate LLT barrier layer and the substrate plate. An apparatus is also disclosed having at least a portion thereof sealed with a tin phosphate LLT barrier layer. | 12-31-2009 |
20100051817 | Systems and methods for determining the shape of glass sheets - Disclosed are systems and methods for determining the shape of a glass sheet during and/or after the forming process. In one example, a system for determining the shape of a glass sheet defining an interior bulk can include a light source, an image capture device and a processor that are configured to calculate the location of an energy centroid within a selected portion of the bulk of the glass sheet. | 03-04-2010 |
20100193353 | SEALING TECHNIQUE FOR DECREASING THE TIME IT TAKES TO HERMETICALLY SEAL A DEVICE AND THE RESULTING HERMETICALLY SEALED DEVICE - A sealing method for decreasing the time it takes to hermetically seal a device and the resulting hermetically sealed device (e.g., a hermetically sealed OLED device) are described herein. The sealing method includes the steps of: (1) cooling an un-encapsulated device; (2) depositing a sealing material over at least a portion of the cooled device to form an encapsulated device; and (3) heat treating the encapsulated device to form a hermetically sealed device. In one embodiment, the sealing material is a low liquidus temperature inorganic (LLT) material such as, for example, tin-fluorophosphate glass, tungsten-doped tin fluorophosphate glass, chalcogenide glass, tellurite glass, borate glass and phosphate glass. In another embodiment, the sealing material is a Sn | 08-05-2010 |
20120028011 | SELF-PASSIVATING MECHANICALLY STABLE HERMETIC THIN FILM - A hermetic thin film includes a first inorganic layer and a second inorganic layer contiguous with the first inorganic layer, wherein the second inorganic layer is formed as a reaction product of the first inorganic layer with oxygen and has a molar volume that is about −1% to 15% greater than a molar volume of the first inorganic layer. An equilibrium thickness of the second inorganic layer is at least 10% of but less than an as-deposited thickness of the first inorganic layer. | 02-02-2012 |
20140120315 | FLEXIBLE MULTILAYER HERMETIC LAMINATE - A multi-layer thin film laminate comprises a dyad layer including a barrier layer and a decoupling layer formed over a substrate. The barrier layer comprises a hermetic glass material selected from the group consisting of tin fluorophosphate glasses, tungsten-doped tin fluorophosphate glasses, chalcogenide glasses, tellurite glasses, borate glasses and phosphate glasses and the decoupling layer comprises a polymer material. | 05-01-2014 |
Dingding An, Brookline, MA US
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20150252068 | GLYCOSPHINGOLIPIDS AND METHODS OF USE THEREOF - The invention provides, inter alia, immunoinhibitory glycosphingolipids and immunoinhibitory alpha-galactosylceamides and compositions and preparations thereof, and methods of use thereof including in the treatment of conditions characterized by increased iNKT cells and/or activity. | 09-10-2015 |
Fei An, Northville, MI US
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20130240315 | DUAL-CLUTCH TRANSMISSION THERMAL MANAGEMENT - A method of cooling a multi-speed dual-clutch transmission (DCT) that is paired with an internal combustion engine in a vehicle includes detecting operation of the vehicle. The method also includes sensing an increase in temperature of a subsystem of the DCT while the vehicle is operating. The method also includes selecting a remedial action in response to the sensed temperature. The method aditionally includes activating the selected remedial action such that the temperature of the subsystem is reduced. | 09-19-2013 |
20130282243 | DUAL-CLUTCH TRANSMISSION THERMAL MANAGEMENT - A method of controlling thermal loading in a multi-speed dual-clutch transmission (DCT) that is paired with an internal combustion engine in a vehicle is provided. The method includes detecting operation of the vehicle and ascertaining a degree of thermal loading on the DCT. The method also includes selecting a remedial action corresponding to the ascertained degree of thermal loading. Additionally, the method includes activating the selected remedial action such that the thermal loading on the DCT is reduced. A vehicle having a DCT, an internal combustion engine, and a controller configured to control thermal loading in the DCT is also disclosed. | 10-24-2013 |
Fenqgi An, Solon, OH US
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20110182910 | METHOD OF TREATING T CELL MEDIATED DISORDERS - A method of treating a T-cell mediated disorders in a tissue includes administering to the tissue of the subject a therapeutically effective amount of a complement antagonist that substantially reduces T-cell differentiation or t-cell inflammatory cytokine generation. | 07-28-2011 |
Gang An, Oklahoma City, OK US
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20110286917 | Novel, Prostate-Specific Gene for Diagnosis, Prognosis and Management of Prostate Cancer - Disclosed are nucleic acid and amino acid sequences encoded by a novel, prostate specific gene (UC41) and diagnostic techniques for the detection of human prostate cancer utilizing such nucleic acid and amino acid sequences. Genetic probes and methods useful in monitoring the progression and diagnosis of prostate cancer are described. Methods of treatment for prostate cancer utilizing antisense constructs or antibodies specific for UC41 gene products are also described. | 11-24-2011 |
Gang An, Durham, NC US
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20120213789 | New Molecular Target for Treatment of Cancer - The present invention concerns preventative, therapeutic, and diagnostic methods and compositions involving UC markers, such as UC 28, for cancer. It includes methods and compositions for targeting cancer cells using a differentiation agent in combination with a therapeutic agent targeted to cells that differentially express a UC marker after exposure to the differentiation agent. The invention also includes methods of inducing immune responses against UC markers, as well as antibodies that recognize UC markers, which may be employed for therapeutic and diagnostic methods. | 08-23-2012 |
Gary An, Chicago, IL US
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20080228456 | MODELING WOUND HEALING - Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis. | 09-18-2008 |
20120271611 | Modeling Wound Healing - Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis. | 10-25-2012 |
Hailing An, Houston, TX US
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20100161250 | SUBSEA CONTROL SYSTEM DIAGNOSIS - Accurate, dependable methods for analyzing operational parameters of subsea control systems and diagnosis/prediction of failures are provided, in particular, methods for detection of leaking and/or clogging in hydraulic control system using recorded pressure signals and evaluating response communication strength (signal amplitude) of field equipment from, for example, subsea control systems. Prediction of failure(s) allows an opportunity to prepare for intervention to minimize the impact of failure before failure occurs, for example, by ordering equipment, tools and/or scheduling an intervention vessel. Similarly, diagnosing a failure drastically shortens the intervention time. | 06-24-2010 |
20110114329 | APPARATUS AND METHOD FOR PROVIDING A CONTROLLABLE SUPPLY OF FLUID TO SUBSEA WELL EQUIPMENT - An apparatus and method for providing a controllable supply of fluid, and optionally power and/or communication signals, to a subsea equipment are provided. The fluid may be a water-based fluid, oil-based fluid, or chemicals. The apparatus includes a reservoir disposed on a seabed for storing a supply of fluid for delivery to the subsea well equipment. A subsea pumping device is configured to receive the fluid from the reservoir, pressurize the fluid, and deliver the pressurized fluid to an accumulator of a hydraulic power unit disposed on the seabed. The hydraulic power unit can store the pressurized fluid and control an output of the pressurized fluid to the subsea well equipment, thereby providing a subsea fluid source for the subsea equipment. | 05-19-2011 |
Hongmei An, Houston, TX US
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20090031712 | CATALYSTS WITH SLOW, PASSIVE RELEASE OF ALKALI IONS - Described is a method of slowly releasing a catalyst for, inter alia, the purpose of soot oxidation in a particulate filter. An example method includes incorporating an alkali metal oxide in a glass. Slow leaching of the alkali from the glass provides a means to gradually deliver the catalyst over extended periods. Additionally, the example method includes increasing the amount of alkaline metal ions that may be leached from the glass. | 02-05-2009 |
Howard An, Glenview, IL US
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20140314726 | FIBROBLASTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE - The present invention concerns methods and compositions for differentiating cells, including human fibroblasts, into chondrocyte-like cells via in vivo mechanical strain. In particular aspects, fibroblasts are delivered to a joint, such as an intervertebral disc, following which the fibroblasts differentiate into chondrocyte-like cells to treat dysfunction of cartilage therein, including to repair degenerated discs, for example. The fibroblasts that do not differentiate to chondrocytic cells because of the location of the cells, as in the fissures of annulus, or other biomechanical and biochemical micro-environment factors, may produce fibrous matrix molecule(s) in aiding tissue repair and regeneration in both nucleus pulposus and annulus fibrosus. In certain aspects, the fibroblasts prior to delivery to the individual are managed in the absence of growth factors, in vitro mechanical strain, and/or matrix molecules, for example. | 10-23-2014 |
Howard S. An, Glenview, IL US
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20110106168 | Laminoplasty Rod System - A laminoplasty rod and rod system that allows for variable angulation, translation (distraction and/or compression) and rotation of a spinal lamina bone portion associated with a laminoplasty, prior to fixation thereof. The laminoplasty rod is configured for use with a polyaxial spinal rod bone screw assembly that is adapted to be anchored to the vertebra associated with the laminoplasty, and is attachable to the spinal lamina bone portion. The laminoplasty rod system provides positional attachment of the laminoplasty rod to the spinal components associated with the laminoplasty and fixation thereof in various orientations. The laminoplasty rod system is characterized by a configured laminoplasty rod that fits into or onto the head of a polyaxial spinal rod bone screw assembly. A bone screw boss, defining a bone screw attachment configuration, is formed at one end of the laminoplasty rod. Preferably, but not necessarily, the bone screw boss is situated at an angled end of the rod having a pre-defined bend that provides for greater variation in rod orientation. | 05-05-2011 |
20130297023 | Methods and Devices For Treating Intervertebral Disc Disease - Provided are methods for treating intervertebral disc degeneration, promoting tissue regeneration in the intervertebral disc, promoting homeostasis of the intervertebral disc, preventing intervertebral disc degeneration, and reducing inflammation of the intervertebral disc in a subject in need thereof comprising administering a myeloid differentiation primary response (88) (MyD88) antagonist to the subject. Also provided is a device, biomaterial or putty for implantation in or near the spine, wherein the device, biomaterial or putty is coated or infused with a myeloid differentiation primary response gene (88) (MyD88) antagonist. | 11-07-2013 |
Howard S. An, Riverwood, IL US
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20090142311 | ENGINEERED INTERVERTEBRAL DISC TISSUE - Surgically implantable tissue engineered intervertebral disc tissues that effectively replicate the physicochemical properties of the corresponding in vivo tissues are provided. Methods for producing such tissues can involve culturing the intervertebral disc cells to produce cells surrounded by an extracellular matrix and culturing the cells and matrix on a semipermeable membrane to form a cohesive tissue. | 06-04-2009 |
Hui Chul An US
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20120120657 | FRONT LIGHT UNIT - Disclosed herein is a front light unit including a transparent insulating substrate; a transparent anode electrode disposed on the insulating substrate; a plurality of organic light-emitting elements disposed on the anode electrode; a transparent cathode electrode disposed on the organic light-emitting elements; and a plurality of reflective plates disposed opposite the organic light-emitting elements in an emission direction of the organic light-emitting elements, and disposed between the insulating substrate and the cathode electrode. | 05-17-2012 |
Jiandi An, Round Rock, TX US
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20130003976 | TECHNIQUES FOR ACCESSING FEATURES OF A HARDWARE ADAPTER - A technique for accessing features of a hardware adapter includes reading a first key from a hardware adapter and attempting to decrypt the first key with a second key. In response to the second key successfully decrypting the first key: encrypted code from the hardware adapter is read; the encrypted code is decrypted with the decrypted first key to generate unencrypted code; and a default code in an executable flash sector of the hardware adapter is over-written with the unencrypted code. In this case, the unencrypted code facilitates access to at least one feature of the hardware adapter that is customer specific. In response to the second key not successfully decrypting the first key, the default code in the executable flash sector of the hardware adapter is not over-written. In this case, the default code facilitates access to one or more features that are not customer specific. | 01-03-2013 |
Jiandi An, Austin, TX US
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20110271008 | Selective TCP Large Receive Aggregation Based On IP Destination Address - An information handling device receives a packet and determines a packet destination for the packet. In turn, the information handling device either aggregates the packet in response to determining that the packet destination is a local destination, or forwards the packet in response to determining that the packet destination is a non-local destination. | 11-03-2011 |
Jiandi A. An, Round Rock, TX US
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20150085879 | Memory Transfer Optimization of Network Adapter Data Placement when Performing Header-Data Split Operations - Mechanisms are provided, in a data processing system comprising a host system and a network adapter, for processing received frames of data over a network connection. The mechanisms receive, in the host system from the network adapter, a plurality of frames of data. The mechanisms record, by the host system, for each frame in the plurality of frames, a header size associated with the frame over a current predetermined interval. The mechanisms determine, by the host system, a receive buffer address offset for receive buffers in the host system for a next predetermined interval based on the recorded header sizes of the plurality of frames over the current predetermined interval. In addition, the mechanisms configure, by the host system, the network adapter to utilize the receive buffer address offset to perform data transfers with the host system. | 03-26-2015 |
20150085880 | Memory Transfer Optimization of Network Adapter Data Placement when Performing Header-Data Split Operations - Mechanisms are provided, in a data processing system comprising a host system and a network adapter, for processing received frames of data over a network connection. The mechanisms receive, in the host system from the network adapter, a plurality of frames of data. The mechanisms record, by the host system, for each frame in the plurality of frames, a header size associated with the frame over a current predetermined interval. The mechanisms determine, by the host system, a receive buffer address offset for receive buffers in the host system for a next predetermined interval based on the recorded header sizes of the plurality of frames over the current predetermined interval. In addition, the mechanisms configure, by the host system, the network adapter to utilize the receive buffer address offset to perform data transfers with the host system. | 03-26-2015 |
Jicheng An US
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20150341663 | METHOD AND APPARATUS FOR RESIDUAL PREDICTION IN THREE-DIMENSIONAL VIDEO CODING - A method and apparatus using pseudo residues to predict current residues for three-dimensional or multi-view video coding are disclosed. The method first receives input data associated with a current block of a current picture in a current dependent view and determines an inter-view reference block in a first inter-view reference picture in a reference view according to a DV (disparity vector), where the current picture and the first inter-view reference picture correspond to same time instance. Pseudo residues are then determined and used for encoding or decoding of the current block, where the pseudo residues correspond to differences between a corresponding region in an inter-time reference picture in the current dependent view and a pseudo reference region in a pseudo reference picture in the reference view, and where the inter-time reference picture and the pseudo reference picture correspond to same time instance. | 11-26-2015 |
20150341664 | METHOD AND APPARATUS OF DISPARITY VECTOR DERIVATION IN THREE-DIMENSIONAL VIDEO CODING - A derived disparity vector is determined based on spatial neighboring blocks and temporal neighboring blocks of the current block. The temporal neighboring blocks are searched according to a temporal search order and the temporal search order is the same for all dependent views. Any temporal neighboring block from a CTU below the current CTU row may be omitted in the temporal search order. The derived DV can also be used for predicting a DV of a DCP (disparity-compensated prediction) block for the current block in the AMVP mode, the Skip mode or the Merge mode. The temporal neighboring blocks may correspond to a temporal CT block and a temporal BR block. In one embodiment, the temporal search order checks the temporal BR block first and the temporal CT block next. | 11-26-2015 |
20150350623 | Method and Apparatus for Efficient Coding of Depth Lookup Table - A method and apparatus for encoding and decoding depth lookup table (DLT) using a constrained table value range are disclosed. For a decoder, a constrained table value range from a minimum table value to a maximum table value of the DLT is decoded from the coded DLT information. Bit map values for depth values in a depth range from (the minimum table value+1) to (the maximum table value−1) are then decoded. The bit map values indicate whether the depth values are in the DLT respectively. The DLT for the current depth map can be reconstructed based on the constrained table value range and the bit map values for the depth values in the depth range. For an encoder, a constrained table value range from a minimum table value to a maximum table value of the DLT is determined and encoded the DLT into coded DLT information. | 12-03-2015 |
Jie An, Temple, TX US
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20140170241 | COILED COIL HELIX CRISTAE MORPHOLOGY 1 (CHCM1) TUMOR MARKER AND CANCER THERAPEUTIC TARGET - Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1. | 06-19-2014 |
Jihyun An, Evanston, IL US
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20110104213 | Porous Biomolecule-Containing Metal-Organic Frameworks - The present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic frameworks can include a metal component and a biomolecule component. The pores located within the frameworks have a pore space and said pore space is capable to adsorb materials therein. These compositions of the present invention are useful in a wide variety of applications, such as, but not limited to, hydrogen and carbon dioxide sequestration, separation and storage; carbon dioxide uptake; and drug storage and release. | 05-05-2011 |
20140163111 | POROUS BIOMOLECULE-CONTAINING METAL-ORGANIC FRAMEWORKS - The invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic frameworks can include a metal component and a biomolecule component. The pores located within the frameworks have a pore space and said pore space is capable to adsorb materials therein. These compositions of the invention are useful in a wide variety of applications, such as, but not limited to, hydrogen and carbon dioxide sequestration, separation and storage; carbon dioxide uptake; and drug storage and release. | 06-12-2014 |
Ju Jin An, Cambridge, MA US
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20090047447 | Method for removing surface deposits and passivating interior surfaces of the interior of a chemical vapor deposition reactor - The present invention relates to plasma cleaning methods for removing surface deposits from a surface, such as the interior of a depositions chamber that is used in fabricating electronic devices. The present invention also provides gas mixtures and activated gas mixtures which provide superior performance in removing deposits from a surface. The methods involve activating a gas mixture comprising a carbon or sulfur source, NF | 02-19-2009 |
Kai-Nam An, Rocheser, MN US
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20110237949 | SYSTEM AND METHOD FOR ANALYZING CARPAL TUNNEL USING ULTRASOUND IMAGING - A system and method is provided for using dynamic ultrasonic imaging to analyze a subject's carpal tunnel and generate risk factors indicative of the health of the subject's subsynovial connective tissue and the subject's risk of developing carpal tunnel syndrome. The system and method uses speckle imaging techniques to track dynamic structures within the carpal tunnel and statistical analysis techniques to compare the properties of these dynamic structures of the subject to those of normal subjects and subjects having carpal tunnel syndrome. | 09-29-2011 |
Kai-Nan An, Rochester, MN US
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20100057209 | TEMPOROMANDIBULAR JOINT FOSSA-EMINENCE PROSTHESIS - A fossa-eminence prosthesis having a nonanatomic surface that is relatively flatter than the native fossa. The articular eminence of the patient can be surgically reduced before implanting the prosthesis. | 03-04-2010 |
20100221347 | ENHANCING SOLUTE TRANSPORT WITHIN A TISSUE SCAFFOLD - This document provides materials and methods related to tissue scaffolds for use in replacing or augmenting various tissues in the body. For example, flexible tissue scaffolds with controlled pore geometry and methods of enhancing solute transport using rhythmic compression (e.g., 1.0 Hz) of tissue scaffolds are provided | 09-02-2010 |
20110319993 | TENDON OR LIGAMENT TISSUE ENGINEERING - This document relates to methods and materials involved in tendon or ligament tissue engineering. For example, methods and materials for generating a composite of acellular tendon or ligament allograft slices seeded with cells and bundled into a graft for tissue repair are provided. | 12-29-2011 |
20120114755 | METHODS AND MATERIALS FOR TISSUE REPAIR - This document relates to methods and materials for treating tendon injury. Specifically, methods and materials for preventing adhesion formation and promoting tissue healing following tendon injury and surgical repair are provided. | 05-10-2012 |
20130030543 | HIP IMPLANT - Provided herein are hip implant devices and related surgical methods. The hip implants and methods can optionally be used in patients of Asian descent. | 01-31-2013 |
20130131823 | ACETABULAR CUP PROSTHESIS - Provided are acetabular cup implant assemblies that can be used in hip replacement surgery. Example assemblies comprise a shell and a liner. The liner can be positioned within a shell. Optionally, the liner can be rotated relative to the shell until the liner is seated in the shell in a position where the liner and shell can be secured to one another. Waveform-shaped features of the shell and liner can guide the relative rotation of the liner and shell. Also provided are methods of seating a liner in shell of an acetabular cup implant assembly | 05-23-2013 |
20140081136 | SYSTEM AND METHOD FOR NON-INVASIVE MEASUREMENT OF CARPAL TUNNEL PRESSURE - Method and system for non-invasive determination of a pressure characteristic associated with carpal tunnel (CT) region of a subject. Speed of a shear wave induced in the tissue of the subject and propagating through the CT region is measured at least once. The pressure characteristic is substantially proportional to determined speed. | 03-20-2014 |
20150245913 | ACETABULAR CUP PROSTHESIS - Provided are acetabular cup implant assemblies that can be used in hip replacement surgery. Example assemblies comprise a shell and a liner. The liner can be positioned within a shell. Optionally, the liner can be rotated relative to the shell until the liner is seated in the shell in a position where the liner and shell can be secured to one another. Waveform-shaped features of the shell and liner can guide the relative rotation of the liner and shell. Also provided are methods of seating a liner in shell of an acetabular cup implant assembly. | 09-03-2015 |
Ke An, Knoxville, TN US
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20090269666 | Lightweight, Durable Lead-Acid Batteries - A lightweight, durable lead-acid battery is disclosed. Alternative electrode materials and configurations are used to reduce weight, to increase material utilization and to extend service life. The electrode can include a current collector having a buffer layer in contact with the current collector and an electrochemically active material in contact with the buffer layer. In one form, the buffer layer includes a carbide, and the current collector includes carbon fibers having the buffer layer. The buffer layer can include a carbide and/or a noble metal selected from of gold, silver, tantalum, platinum, palladium and rhodium. When the electrode is to be used in a lead-acid battery, the electrochemically active material is selected from metallic lead (for a negative electrode) or lead peroxide (for a positive electrode). | 10-29-2009 |
20110294008 | Lightweight, Durable Lead-Acid Batteries - A lightweight, durable lead-acid battery is disclosed. Alternative electrode materials and configurations are used to reduce weight, to increase material utilization and to extend service life. The electrode can include a current collector having a buffer layer in contact with the current collector and an electrochemically active material in contact with the buffer layer. In one form, the buffer layer includes a carbide, and the current collector includes carbon fibers having the buffer layer. The buffer layer can include a carbide and/or a noble metal selected from of gold, silver, tantalum, platinum, palladium and rhodium. When the electrode is to be used in a lead-acid battery, the electrochemically active material is selected from metallic lead (for a negative electrode) or lead peroxide (for a positive electrode). | 12-01-2011 |
Kwang Hyup An, Ann Arbor, MI US
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20090134025 | Scanning device with a probe having an organic material - A probe for a scanning device having an anode, a cathode, and an organic material. The organic material is positioned between the anode and the cathode. The organic material is operable for at least one of emitting and detecting light by an electrical bias applied between the anode and the cathode. | 05-28-2009 |
20110291079 | SURFACE PLASMON-MEDIATED ENERGY TRANSFER OF ELECTRICALLY-PUMPED EXCITONS - An electrically pumped light emitting device emits a light when powered by a power source. The light emitting device includes a first electrode, a second electrode including an outer surface, and at least one active organic semiconductor disposed between the first and second electrodes. The device also includes a dye adjacent the outer surface of the second electrode such that the second electrode is disposed between the dye and the active organic semiconductor. A voltage applied by the power source across the first and second electrodes causes energy to couple from decaying dipoles into surface plasmon polariton modes, which then evanescently couple to the dye to cause the light to be emitted. | 12-01-2011 |
Kwang Hyup An, Rexford, NY US
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20150034910 | ORGANIC X-RAY DETECTOR - An x-ray imaging system includes an organic x-ray detector having a layered structure composed of a scintillator layer disposed on a first electrode layer and an absorber layer sandwiched between the first electrode layer and a second electrode layer. The second electrode layer is disposed on a TFT array and the TFT array is disposed on a substrate. The absorber layer includes a donor material and an acceptor material, and the donor material contains a low bandgap polymer. | 02-05-2015 |
20150144889 | ORGANIC X-RAY DETECTOR WITH BARRIER LAYER - An organic x-ray detector and a method of making the organic x-ray detector are disclosed. The x-ray detector includes a TFT array disposed on a substrate, an organic photodiode layer disposed on the TFT array, a barrier layer disposed on the photodiode layer, and a scintillator layer disposed on the barrier layer, such that the barrier layer includes at least one inorganic material. | 05-28-2015 |
20150187837 | METHOD OF MANUFACTURING PHOTODIODE DETECTORS - A radiation detector assembly including an organic photodetector that generate charge in response to an incident radiation, a thin film transistor array including a plurality of pixels. The plurality of pixels may produce electric signals corresponding to the charge generated by the organic photodetector. The radiation detector assembly also includes a spacer disposed on the thin film transistor array. The spacer surrounds one or more pixels and may confine the organic photodetector within the surrounded one or more pixels such that the surrounded one or more pixels are electrically isolated from a neighboring pixel. | 07-02-2015 |
Le An, Carrboro, NC US
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20150154229 | SCALABLE ATTRIBUTE-DRIVEN IMAGE RETRIEVAL AND RE-RANKING - Retrieval of images of objects from a large-scale database of object images, based on a query image. The database may, for example, contain images of objects such as faces, vehicles, people and luggage. Semantic attributes such as doors or windows in the case of vehicles are used as high level semantic cues to determine identities of objects in the images. Salient visual characteristics of the images are labeled with attribute information, and a transformation is learned so as to transform the labeled visual characteristics into a discrimination vector that discriminates between the labels. A similarity metric is learned using the discrimination vectors, such that different images depicting the same object are determined to be close while those having different objects are determined to be far apart. Candidates are retrieved based on a query image, and a re-ranking step may be applied to improve results. Validation experiments are described. | 06-04-2015 |
Li An, Sun Prairie, WI US
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20130142913 | SANDWICH HAVING AN EDIBLE CASING LINK - A food product having a pre-cooked loose meat filling along with a seasoning mix is provided in an edible casing. The edible casing is filled with the pre-cooked loose meat filling and the seasoning mix to produce a filled casing that is subsequently cooked to produce a meat link. The food product also may have a raw meat batter that is combined with the pre-cooked loose meat filling and filled into the edible casing along with the pre-cooked loose meat filling prior to subsequent cooking of the meat link. The pre-cooked loose meat filling may include discrete, not fully ground meat material including meat finely chopped, diced, chunks, shred, and splinters of meat. Alternatively, the pre-cooked loose meat filling may include cooked ground meat, though the pre-cooked loose meat filling will still have individual pieces larger than an emulsified product. | 06-06-2013 |
Lin An, Portland, OR US
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20120063665 | METHOD AND APPARATUS FOR QUANTITATIVE IMAGING OF BLOOD PERFUSION IN LIVING TISSUE - Embodiments provide methods and systems for imaging, and, more specifically, to a method and apparatus for quantitative imaging of blood perfusion in living tissue. Some embodiments are directed to methods of obtaining quantitative imaging of blood perfusion in living tissues using Doppler optical micro-angiography (DOMAG). | 03-15-2012 |
20140288419 | METHOD AND APPARATUS FOR QUANTITATIVE IMAGING OF BLOOD PERFUSION IN LIVING TISSUE - Embodiments provide methods and systems for imaging, and, more specifically, to a method and apparatus for quantitative imaging of blood perfusion in living tissue. Some embodiments are directed to methods of obtaining quantitative imaging of blood perfusion in living tissues using Doppler optical micro-angiography (DOMAG). | 09-25-2014 |
Linan An, Oviedo, FL US
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20090209405 | Method for Synthesizing Bulk Ceramics and Structures from Polymeric Ceramic Precursors - A method and product made by using a polymeric ceramic precursor to synthesize dense, crack-free bulk ceramics in a technique using a sacrificial mold provides a ceramic structure for many technical, medical and industrial applications. The novel process uses an open cell material as a sacrificial mold to shape a ceramic precursor during curing. The cured ceramic green body can be machined and shaped to form the desired ceramic structure prior to final pyrolysis. The open cell material forms gas release paths to release large amount of gases generated during the pyrolysis of the cured ceramic precursor. After pyrolysis, an intact, dense, crack-free ceramic structure with high purity, strength and durability is obtained. Uses of the present invention include, but are not limited to, bulk ceramic parts, ceramic crucibles, a replacement material in some applications involving glass, silicon carbides, silicon nitrides, hafnium carbide and the like. | 08-20-2009 |
20100321191 | CERAMIC SENSORS FOR WIRELESS HIGH-TEMPERATURE SENSING - A RF resonator for sensing a physical or an environmental parameter includes a substrate having a substrate surface. A polymer-derived ceramic (PDC) element is positioned on or within the substrate surface. The RF resonator has a resonant frequency that changes as a function of the physical or environmental parameter. A system for wirelessly sensing at least one physical or environmental parameter includes at least one RF resonator and a wireless RF reader located remotely from the RF resonator for transmitting a wide-band RF interrogation signal that excites the RF resonator. The wireless RF reader detects a sensing signal retransmitted by the RF resonator and includes a processor for determining the physical or environmental parameter at the location of the RF resonator from the sensing signal. | 12-23-2010 |
20150028889 | LOW-PROFILE WIRELESS PASSIVE RESONATORS FOR SENSING - A resonator for sensing a physical or an environmental parameter includes a support having a top surface that provides a ground plane, and a polymer-derived ceramic (PDC) element positioned on the top surface including a PDC layer, and a metal patch on the PDC layer. The metal patch is electrically isolated from all surrounding structure, and the resonator has a resonant frequency that changes as a function of the physical or environmental parameter. A system for wirelessly sensing a physical or environmental parameter includes at least one resonator and a wireless RF reader located remotely from the resonator for transmitting a wide-band RF interrogation signal that excites the resonator. The wireless RF reader detects a sensing signal retransmitted by the resonator and includes a processor for determining the physical or environmental parameter at the location of the resonator from the sensing signal. | 01-29-2015 |
Ling-Ling An, Boyds, MD US
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20080311122 | Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, lupus, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 12-18-2008 |
20090169546 | HIGH AFFINITY ANTIBODIES AGAINST HMGB1 AND METHODS OF USE THEREOF - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 07-02-2009 |
20100061987 | High Affinity Antibodies Against HMGB1 and Methods Of Use Thereof - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 03-11-2010 |
20110123528 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 05-26-2011 |
20110165622 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 07-07-2011 |
20110287023 | High Affinity Antibodies Against HMGB1 and Methods of Use Thereof - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 11-24-2011 |
20120230985 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 09-13-2012 |
20130171070 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 07-04-2013 |
20140303355 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 10-09-2014 |
20150376295 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 12-31-2015 |
20160002352 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 01-07-2016 |
20160002353 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 01-07-2016 |
Moens An, Baltimore, MD US
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20100004248 | Use of a Nitric Oxide Synthase Modulator for the Treatment of Cardiac Indications - The invention features compositions and methods for modulating NOS that are useful for the prevention and treatment of cardiac diseases and disorders, including cardiac hypertrophy and cardiac dilation. In particular, the invention provides compositions comprising tetrahydrobiopterin (BH4), alone or in combination with one or more additional compounds. | 01-07-2010 |
Myeong Gu An US
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20150274339 | INDIVIDUALIZED NUTRIENT PREPARATION APPARATUS AND SYSTEM - Disclosed is an individualized nutrient preparation apparatus to prepare an individualized nutrient according to user characteristics. The individualized nutrient preparation apparatus includes a data processing unit configured to generate individual nutrient prescription data, a plurality of supply units configured to independently supply different nutrient granules according to the individual nutrient prescription data, each of which supplying a predetermined number set of the nutrient granules, and a packing unit configured to pack a mix of the nutrient granules. | 10-01-2015 |
Na An, Salt Lake City, UT US
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20120091005 | DETECTION OF NUCLEIC ACID LESIONS AND ADDUCTS USING NANOPORES - Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion ( | 04-19-2012 |
20150185200 | DETECTION OF NUCLEIC ACID LESIONS AND ADDUCTS USING NANOPORES - Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion ( | 07-02-2015 |
Pao Yu An, Morris Plains, NJ US
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20080295431 | Reversible planking system and method for making thereof - A reversible composite simulated beadboard planking and a method for making the same are provided. The planking may include a first finished side, a second finished side opposite the first finished side, a first pattern including integrally-formed uneven profile simulating a beadboard of a first plank width on the first finished side, a second pattern including integrally-formed uneven profile simulating a beadboard of a second plank width different than the first plank width on the second finished side, a base pigment distributed substantially uniformly throughout the planking, and a tongue structure on a first edge substantially adjacent to the first finished side and the second finished side, and a groove structure on a second edge opposite the first edge, the groove structure configured to receive the tongue structure from another similarly configured composite planking. | 12-04-2008 |
Ping An, Katy, TX US
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20080232193 | Methods for Noise Removal and/or Attenuation from Seismic Data by Wavelet Selection - Seismic data traces contain noises that may exist in the form of wavelets and be represented by wavelets. A method is established for removing or attenuating the noises in the seismic data traces by removing the wavelets or representing wavelets of noises in the seismic data traces. The method involves three steps. (1) Decomposition of each seismic data trace into a set of time dependent wavelets of different shapes. The obtained wavelets can be named with their dominant frequency or other characteristics of the wavelets. (2) Proper selection of the wavelets to form a new set of wavelets that contains mostly signal wavelets and rejects the wavelets of noises and representing wavelets of noises as mush as possible. This step can also be described as to remove the wavelets of noises and representing wavelets of noises from the obtained set of wavelets from step one and form a new set of wavelets. (3) Composition or reconstruction of a new seismic data trace with the new selected set of wavelets. The new reconstructed seismic data trace is the resulting seismic data trace. It normally have much higher signal to noise ratio than the original seismic data trace. | 09-25-2008 |
20080285383 | System and method for processing seismic data for interpretation - A method is provided for processing seismic data for interpretation. The method includes recording an original seismic data trace, decomposing the original seismic data trace into a set of predefined wavelets, and reconstructing a seismic data trace from, at least a subset of, the set of wavelets. | 11-20-2008 |
Qi An, New Brighton, MN US
Qi An, Blaine, MN US
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20120157856 | HEART FAILURE DETECTION WITH A SEQUENTIAL CLASSIFIER - A system and method for automatically analyzing heart failure in a patient, including collecting physiological data from a patient using at least a first sensor and a second sensor to collect two or more sensor measurements, and calculating a first composite value based on at least a first sensor measurement wherein the first composite value is an indication of a likelihood that the patient's heart failure status has changed. If the first composite value is outside of a first specified range, then a second composite value is calculated based on at least a second sensor measurement, wherein the second composite value is an indication of a likelihood that the patient's heart failure status has changed. If the second composite value is outside of a second specified range, then an alert of change in heart failure status is generated. | 06-21-2012 |
20130116578 | RISK STRATIFICATION BASED HEART FAILURE DETECTION ALGORITHM - A system comprises a risk analysis module and a worsening heart failure (WHF) detection module. The risk analysis module measures at least one first physiological parameter of a subject using a physiological sensor of an ambulatory medical device, and determines a heart failure (HF) risk score for the subject according to the at least one measured first physiological parameter. The HF risk score indicates susceptibility of the subject to experiencing a HF event. The WHF detection module measures at least one second physiological parameter of the subject using the same or different physiological sensor, and generates an indication of prediction that the subject will experience a WHF event when the at least one second physiological parameter satisfies a WHF detection algorithm. The risk analysis module adjusts generation of the indication by the WHF detection algorithm according to the determined HF risk score. | 05-09-2013 |
20130178786 | REMOTE CLOSED-LOOP TITRATION OF DECONGESTIVE THERAPY FOR THE TREATMENT OF ADVANCED HEART FAILURE - An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets. | 07-11-2013 |
20130237773 | HEART SOUND DETECTION SYSTEMS AND METHODS USING UPDATED HEART SOUND EXPECTATION WINDOW FUNCTIONS - Heart sound detection systems and methods can use updated heart sound expectation window functions to detect heart sounds. In an example, an initial heart sound expectation window function that describes a heart sound timing can be a function of a physiologic variable such as heart rate, intrinsic vs. non-intrinsic beat, respiration rate, index of circadian timing, or posture. The function can include at least one characteristic parameter that describes a value of the heart sound timing at a specified value of the physiologic variable. In an example, information about a patient heart sound can be detected and used to update a characteristic parameter of an initial heart sound expectation window function, and an updated heart sound expectation window function can be provided using the updated characteristic parameter. | 09-12-2013 |
20140031643 | HEART FAILURE PATIENTS STRATIFICATION - A system, apparatus and method are provided to quantify a risk of worsening heart failure for subject using at least one physiological sensor circuit such as, for example, a heart sound sensor, a respiration sensor, a cardiac activity sensor, or other sensor circuit. A central tendency measurement of the at least one physiological sensor can be used to quantify the risk of worsening heart failure of the subject. | 01-30-2014 |
20140031888 | ELECTRODE DISPLACEMENT DETECTION - Electrode displacement can be detected using a thoracic impedance or conductivity signal. The thoracic impedance or conductivity signal can be filtered to attenuate cardiac contraction (stroke) and respiration components. A fluid status component of the thoracic impedance or conductivity signal can be used to detect a posture-shift related electrode displacement, such as can result from left ventricular/coronary sinus (LV/CS) lead pullback upon a recumbent to upright posture shift. | 01-30-2014 |
20140155762 | METHOD AND APPARATUS FOR DETECTING SUBAUDIBLE CARDIAC VIBRATIONS - A monitoring system senses a physiological signal indicative of mechanical vibrations including audible and/or subaudible frequency ranges and presents information related to the physiological signal to a user. The presented information includes subaudible components of the physiological signal. In various embodiments, the information can be presented as a visual signal representing the mechanical vibrations including the subaudible components, an audial signal representing the mechanical vibrations having a spectrum shifted to an audible frequency range, and/or an audial signal representing the mechanical vibrations having a spectrum compressed into an audible frequency range. An example of the physiological signal can include a heart sound signal indicative of heart sounds including cardiac mechanical vibrations in audible and subaudible frequency ranges. | 06-05-2014 |
20140236029 | ALGORITHM ADAPTATION TO AN EXTERNAL IMPACT ON THE DATA - Devices and methods for detecting a physiological target event such as events indicative of HF decompensation status are described. An ambulatory medical device is configured to determine the presence and timing of a confounding event, segment a sensed physiological signal into at least two data segments, adjust the physiological signal by removing or lessening the impact of the confounding event on the physiological signal. The adjusted data can be presented to the user, and the ambulatory medical device can detect the target events using the adjusted physiologic signal. In some embodiments, the ambulatory medical device can be configured to detect an event indicative of HF decompensation using a physiological signal and the information of the detected confounding event. | 08-21-2014 |
20140275925 | DETERMINING SYSTOLIC TIME INTERVALS USING HEART SOUNDS - Systems and methods are provided for using information from a subject heart sound signal and information from a subject physiological pulsatile signal to identify subject systolic time intervals. An example system for identifying systolic time intervals includes a heart sound detector circuit, configured to detect a subject heart sound signal using an acoustic signal. The system can include a physiological signal sensing circuit configured to detect a physiological pulsatile signal, including at least one of a pulsatile cervical impedance signal or a pulsatile pulmonary artery pressure signal. A timing circuit can be configured to calculate a systolic time interval between a feature on the heart sound signal and a feature on the pulsatile signal. A subject physiologic diagnostic indication can be provided using information from the timing circuit about the systolic time interval. | 09-18-2014 |
20140276163 | DIAGNOSTIC AND OPTIMIZATION USING EXERCISE RECOVERY DATA - An apparatus, such as a cardiac function management system can detect heart sounds following a sensed transition in physical activity level, such as from an elevated physical activity level to rest. A technique can include systems, methods, machine-readable media, or other techniques that can include identifying a physical activity level transition, receiving a heart sound signal, determining characteristics of the heart sound and subject physiologic activity to provide an indication, such as a heart failure status indication. | 09-18-2014 |
20140276164 | HEART FAILURE MANAGEMENT TO AVOID REHOSPITALIZATION - Systems and methods are described for subject rehospitalization management. In an example, multiple physiologic signals can be obtained from a subject using multiple sensors. In response to a hospitalization event, pre-hospitalization characteristics of the multiple physiologic signals can be identified. Post-hospitalization characteristics of the multiple physiologic signals can be identified, including characteristics that differ from their corresponding pre-hospitalization characteristics. Later subsequent physiologic signals can be further monitored after the hospitalization event, such as using the same multiple sensors, and subsequent physiologic signal characteristics can be identified. In an example, a heart failure diagnostic indication can be determined using information about the pre-hospitalization characteristics, the post-hospitalization characteristics, and the subsequent characteristics. Information about relative changes in signal characteristics from multiple sensors can be used to identify particular subject physiologic signals to monitor during subsequent periods. | 09-18-2014 |
20140277235 | SYSTEM AND METHODS FOR IMPROVING DEVICE THERAPY USING MULTIPLE SENSOR METRICS - Devices and methods for improving device therapy such as cardiac resynchronization therapy (CRT) by determining a desired value for a device parameter are described. An ambulatory medical device can receive one or more physiologic signals and generate multiple signal metrics from the physiologic signals. The ambulatory medical device can determine a desired value for a device parameter, such as a timing parameter used for controlling the delivery of CRT pacing to various heart chambers, using information fusion of signal metrics that are selected based on one or more of a signal metric sensitivity to perturbations to the device parameter in response to a stimulation, a signal metric variability in response to a stimulation, or a covariability between two or more signal metrics in response to a stimulation. The ambulatory medical device can program a stimulation using the desired device parameter value, and deliver the programmed stimulation to one or more target sites to achieve desired therapeutic effects. | 09-18-2014 |
20140277237 | DEVICE BASED OPTIMIZATION OF DEVICE THERAPIES - A system may include an external medical device (e.g., a patch) including one or more physiological sensors configured to sense one or more physiological parameters of a subject when the subject is ambulatory. The external medical device may be configured to communicate information related to the sensed one or more physiological parameters for determining and/or modifying at least one cardiac therapy parameter of an implantable medical device (e.g., pacemaker, implantable cardioverter defibrillators, or cardiac resynchronization therapy device). In some situations, an indication or notification may be generated corresponding to the determined and/modified cardiac therapy parameter. | 09-18-2014 |
20140277238 | SYSTEM AND METHODS FOR IMPROVING DEVICE THERAPY USING HEART SOUNDS - Devices and methods for improving device therapy such as cardiac resynchronization therapy (CRT) by determining a desired value for a device parameter are described. An ambulatory medical device can be configured to detect a heart sound signal and generate one or more heart sound metrics, detect a characteristic indicative of cannon waves, and determine a desired value for a device parameter, such as a timing parameter which can be used to control the delivery of CRT pacing to various heart chambers. The desired device parameter value can be determined using the heart sound metrics and the characteristic indicative of the cannon waves. The ambulatory medical device can program stimulation using the desired device parameter value, and deliver the programmed stimulations to one or more target sites to achieve desired therapeutic effects. | 09-18-2014 |
20140277239 | ESTIMATING ELECTROMECHANICAL DELAY TO OPTIMIZE PACING PARAMETERS IN RBBB PATIENTS - Stimulation energy can be provided to stimulate synchronous ventricular contractions. Interval information obtained from a cardiac electrical heart signal and a cardiac mechanical heart signal can be used to determine a right ventricular activation time. The interval information can provide a cardiac stimulation indication. | 09-18-2014 |
20140277240 | SYSTEM AND METHOD FOR CHANGING DEVICE PARAMETERS TO CONTROL CARDIAC HEMODYNAMICS IN A PATIENT - Pacing parameters may be adjusted to increase the cardiac output of a patient's heart while a patient is awake and/or active and the demand placed on the heart may be greatest, and to decrease or hemodynamic efficiency while a patient is at rest so that the heart itself has time to rest before the next period of higher demand for efficiency begins. This may aid in lessening the strain placed on the heart by making the heart work hard when needed such as when the patient is active, and by permitting the heart to “rest” when the patient is relatively inactive. | 09-18-2014 |
20140277243 | HEART SOUNDS TEMPLATE COMPARISON TO IDENTIFY TRUE PACING MODE - An apparatus may include an implantable therapy circuit that provides bi-ventricular pacing to a subject, a heart sound signal sensing circuit that produces a sensed heart sound signal that is representative of at least one heart sound associated with mechanical cardiac activity, a memory circuit to store one or more heart sound templates of cardiac capture, and a comparison circuit that compares a segment of the sensed heart sound signal to the one or more heart sound templates of cardiac capture to identify ventricles in which cardiac capture was induced by the bi-ventricular pacing. In some situations, an indication of the ventricles in which cardiac capture was induced may be generated according to the comparison. | 09-18-2014 |
20140343438 | METHODS AND APPARATUS FOR DETECTING HEART FAILURE EVENT USING PATIENT CHRONIC CONDITIONS - Devices and methods for detecting physiological target event such as events indicative of HF decompensation status are described. A medical device is configured to receive at least a first and a second chronic condition indictors of a patient, receive one or more physiologic signals from the patient, and generate a plurality of signal metrics when the first and the second chronic condition indicators meet their respective criterion. The medical device can detect the target event or condition using one or more patient-specific signal metrics selected from a group including both the first and the second set of the signal metrics. The medical device and the methods can be configured to detect an event indicative of HF decompensation. | 11-20-2014 |
20140343439 | METHODS AND APPARATUS FOR STRATIFYING RISK OF HEART FAILURE DECOMPENSATION - Devices and methods for identifying patient at elevated risk of developing future heart failure (HF) events, such as events indicative of HF decompensation status, are described. The devices and methods can stratify the risk using sensor signals or signal metrics selected in accordance with patient chronic conditions. A medical device can receive a patient status input including at least a first and a second chronic condition indicators, sense one or more physiologic signals from the patient, and generate a plurality of signal metrics from the physiologic signals when the first chronic condition indicator and the second chronic condition indicator meets respective criterion. One or more patient-specific signal metrics can be selected from a group including the signal metrics selected for both the first and the second chronic conditions. A risk stratification algorithm can use the selected one or more patient-specific signal metrics to compute a composite risk index indicative of the probability of the patient later developing an event indicative of worsening of HF. | 11-20-2014 |
20150073203 | HEART FAILURE SYSTEMS AND METHODS - Embodiments of the disclosure include medical device systems and related methods. In an embodiment, the disclosure includes a medical device system. The medical device system can include a cardiac device. The cardiac device can include a processor, a memory, a communications circuit, and one or more sensors. The cardiac device can be configured to engage a sensor mode specific for patients receiving or having implanted ventricular assist devices. The cardiac device can be configured to process data as specified by the sensor mode specific for patients receiving or having implanted ventricular assist devices. In an embodiment, the disclosure includes a method for monitoring heart failure patients. In an embodiment, the disclosure includes a method of controlling devices for heart failure patients. Other embodiments are also included herein. | 03-12-2015 |
20150105835 | METHODS AND APPARATUS FOR DETECTING HEART FAILURE EVENT USING IMPEDANCE VECTOR SWITCHING - Devices and methods for detecting physiological target event such as events indicative of heart failure (HF) decompensation status are described. An ambulatory medical device (AMD) can detect device site maturation such as in a device encapsulation pocket, and classify the maturation status into one of two or more device site maturation states. The AMD can include an electrical impedance analyzer circuit that can measure a first maturation-insensitive impedance vector and a second maturation-sensitive impedance vector. At least one impedance vector can be selected or a composite impedance vector can be generated in accordance with the classified device site maturation state. The AMD can generate an impedance indicator using the selected or composite impedance vector, and detect a target physiologic event indicative of worsening of HF using the impedance indicator. | 04-16-2015 |
20150126878 | HEART FAILURE EVENT DETECTION AND RISK STRATIFICATION USING HEART SOUND - Devices and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events are described. A medical device can detect contextual condition associated with a patient, such as an environmental context or a physiologic context, sense a heart sound signal, and perform multiple measurements of heart sound features in response to the detected patient contextual condition meeting specified criterion. The contextual condition includes information correlating to or indicative of a change in metabolic demand of a patient. The medical device can use the physiologic signals to calculate one or more signal metrics indicative of diastolic function of the heart such as a trend of the heart sound features. The medical device can use the signal metrics to detect an HF event or to predict the likelihood of the patient later developing an HF event. | 05-07-2015 |
20150126883 | METHODS AND APPARATUS FOR DETECTING HEART FAILURE DECOMPENSATION EVENT AND STRATIFYING THE RISK OF THE SAME - Devices and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events, such as events indicative of HF decompensation status, are described. The devices and methods can detect an HF event or predict HF risk using one or more physiologic sensor signals including an electrogram and a heart sound signal. A medical device can use the physiologic signals to calculate one more signal metrics indicative of systolic function of the heart, including relative timing between first and second signal features selected from signal features generated from the electrogram or the heart sound signals. The medical device can detect an HF event using the signal metrics, or use the signal metrics to calculate a composite risk indicator indicative of the likelihood of the patient later developing an event indicative of worsening of HF. | 05-07-2015 |
20150141953 | REMOTE CLOSED-LOOP TITRATION OF DECONGESTIVE THERAPY FOR THE TREATMENT OF ADVANCED HEART FAILURE - An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets. | 05-21-2015 |
20150157221 | METHODS AND APPARATUS FOR PREDICTING HEART FAILURE EVENT - Devices and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events, such as events indicative of HF decompensation status, are described. The devices and methods can detect an HF event or predict HF risk using signal transfigurations on different portions of a physiologic signal. A system can comprise a physiologic signal analyzer circuit that can generate a signal trend of a signal feature calculated using one or more physiologic signals obtained from a patient. A signal transformation circuit can dynamically generates first and second transformations, apply the transformations to respective first and second portions of the signal trend, and generate respectively a first and second transformed signal trends. A target physiologic event detector circuit can detect a target physiologic event such as an event of worsening HF using a comparison of the first and second transformed signal trends. | 06-11-2015 |
20150157229 | MEASURING ATRIAL FIBRILLATION BURDEN USING IMPLANTABLE DEVICE BASED SENSORS - An apparatus may include a sensing circuit and an arrhythmia detection circuit. The sensing circuit is configured to generate a sensed physiological signal representative of cardiac activity of a subject. The arrhythmia detection circuit is configured to monitor ventricular depolarization (V-V) intervals using the sensed physiological signal, detect when at least a portion of the V-V intervals satisfies an arrhythmia detection threshold interval, calculate a value of variability of the V-V intervals and calculate a value of variability of a systolic portion of the V-V intervals in response to the detection, and generate an indication of atrial fibrillation (AF) according to a comparison including the value of variability of the V-V intervals and the value of variability of the systolic portion of the V-V intervals and provide the indication to at least one of a user or process. | 06-11-2015 |
20150157234 | PHYSIOLOGIC RESPONSE TO A THERAPY CHANGE USING A VENTRICULAR FILLING CHARACTERISTIC - A system includes a therapy control circuit, a therapy output circuit; and a physiologic interval sensing circuit configured to receive information about subject physiologic intervals. The therapy circuit is configured to determine a change in therapy that is provided by the therapy output circuit, determine that the change in therapy includes a change to a maximum interval of cardiac electrostimulation provided according to the therapy, detecting a change in a ventricular filling characteristic of the subject in response to the change in maximum interval of cardiac electrostimulation, determine an indication of a physiologic response of the subject to the therapy change using information about the change in the ventricular filling characteristic, and update the subject therapy provided by the therapy output circuit when the determined indication of the physiologic response to the therapy change indicates an increased likelihood of worsening health status of the subject. | 06-11-2015 |
20150157273 | HEART FAILURE EVENT PREDICTION USING CLASSIFIER FUSION - Systems and methods for detecting a heart failure (HF) event indicative of worsening of HF, or for identifying patient at elevated risk of developing future HF event, are described. The system and methods can detect an HF event or predict HF risk using a multitude of fusion algorithms or classifiers, each employing one or more physiologic sensor signals. A system can comprise two or more partial predictor circuits each can adaptively generate a dynamic computational model (DCM). Each partial predictor circuit can determine a partial risk index indicating a likelihood of the patient developing a precursor physiologic event indicative or correlative of a future HF event. The system can include a prediction fusion circuit that can combine the partial risk indices and generate a composite risk indicator for detecting or predicting a likelihood of the patient developing a future HF event. | 06-11-2015 |
20150250428 | HEART FAILURE EVENT DETECTION USING MULTI-LEVEL CATEGORICAL FUSION - Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition. The categorical fusion circuit uses the categorical risk indices to generate a composite risk indicator indicating likelihood of the patient developing the target physiologic event. | 09-10-2015 |
20150327776 | SYSTEM AND METHODS FOR AUTOMATIC DIFFERENTIAL DIAGNOSIS OF WORSENING HEART FAILURE - Devices and methods for differentially diagnosing between worsening heart failure (HF) and other diseases or medical conditions are described. A medical system can receive patient information including one or more physiologic signals, and detect a respective physiologic feature from each of the one or more received physiologic signals. The medical system can include a differential diagnosis circuit that generates one or more signal metrics, receive two or more candidate conditions associated with the change in patient physical or physiological status, and determine a respective diagnostic score for each of the candidate conditions. The diagnostic score can indicate likelihood the change in the patient physical or physiologic status being caused by the corresponding candidate condition. A user interface can be provided to generate a presentation of the detected physiologic features and the diagnostic scores associated with the candidate conditions. | 11-19-2015 |
20150342466 | SYSTEM AND METHODS FOR DETECTING ATRIAL TACHYARRHYTHMIA USING HEMODYNAMIC SENSORS - Systems and methods for detecting atrial tachyarrhythmias such as atrial fibrillation (AF) are disclosed. A medical system can sense a heart rate (HR) output and a hemodynamic status output. An AF detector circuit automatically determines a first detection criterion and a different second detection criterion. The first detection criterion can be more sensitive to the presence of the AF episode than the second detection criterion, and the second detection criterion can be more specific to the AF episode than the first detection criterion. The AF detector circuit detects an AF onset event using the first detection criterion and at least one of the heart rate output or the hemodynamic status output, and detects an AF termination event using the second detection criterion and at least one of the heart rate output or the hemodynamic status output. | 12-03-2015 |
20150342487 | SYSTEMS AND METHODS FOR EVALUATING HEMODYNAMIC RESPONSE TO ATRIAL FIBRILLATION - Systems and methods for assessing hemodynamic status of a patient experiencing atrial tachyarrhythmia such as an atrial fibrillation (AF) episode are disclosed. A system can comprise an atrial tachyarrhythmia detection circuit configured to detect an AF episode, a hemodynamic sensor circuit configured to sense at least one hemodynamic signal, and a hemodynamic status analyzer circuit that can calculate one or more signal metrics using the sensed hemodynamic signal during the AF episode. The hemodynamic status analyzer circuit can categorize the hemodynamic status of the patient into one of two or more categorical hemodynamic status levels which indicate elevated hemodynamic impact of the detected AF episode. A user interface can provide to an end-user a presentation of the categorized hemodynamic status level during AF. | 12-03-2015 |
20150342492 | METHOD AND APPARATUS FOR DETECTING ATRIAL TACHYARRHYTHMIA USING HEART SOUNDS - A cardiac rhythm management system senses a cardiac signal indicative of heartbeats and an acoustic signal indicative of heart sounds and detects atrial tachyarrhythmia based on the sensed cardiac and acoustic signals. In various embodiments, the system senses the cardiac and acoustic signals without using an atrial lead, thus allowing for, for example, monitoring atrial fibrillation burden in a heart failure patient who does not wear an implantable device with an atrial lead. In various embodiments, the system detects heartbeats and heart sounds, measures parameters associated with the detected heartbeats and heart sounds, and detects one or more specified types of atrial tachyarrhythmia using the measured parameters. In various embodiments, the measured parameters are selected from heart rate, heart sound amplitude, cycle length variability, and systolic and diastolic intervals. | 12-03-2015 |
20150342540 | HEART FAILURE EVENT DETECTION AND RISK STRATIFICATION USING HEART RATE TREND - Systems and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events such as HF decompensation are described. A medical system can detect a contextual condition associated with a patient, including an environmental context or a physiologic context. The contextual condition includes information indicative or correlative of a change in metabolic demand. The system can include a heart rate (HR) analyzer circuit that extracts a HR feature from a cardiac activity signal, and perform multiple HR feature measurements in response to the detected patient contextual condition meeting a specified criterion. The system can calculate one or more signal metrics including a HR metric using the HR feature measurements. The system can detect an HF event using the signal metrics, or use the signal metrics to calculate a composite risk indicator indicative of the patient's likelihood of developing a future HF event. | 12-03-2015 |
20150343223 | SYSTEM AND METHODS FOR TREATING ATRIAL FIBRILLATION USING HEMODYNAMIC RESPONSES - Systems and methods for treating atrial tachyarrhythmias such as atrial fibrillation (AF) are disclosed. By monitoring a patient's hemodynamic sensor response to a candidate AF therapy, the present systems and methods can be used to determine an individualized AF therapy leading to a desirable hemodynamic outcome. A medical system can include one or more programmable therapy circuits and a hemodynamic sensor circuit. The system includes a therapy selection circuit that automatically programs and sequentially delivers at least a first candidate therapy and a different second candidate therapy. By comparing the values of a hemodynamic parameter in response to or during the first candidate therapy to that in response to or during the second candidate therapy, a desired AF therapy can be determined as the candidate therapy that leads to faster or more significant hemodynamic recovery. | 12-03-2015 |
20150351660 | ABSOLUTE THORACIC IMPEDANCE FOR HEART FAILURE RISK STRATIFICATION - An apparatus may include a sensing circuit configured to generate a sensed physiological signal representative of thoracic impedance of a subject and a controller circuit. The a controller circuit is electrically coupled to the sensing circuit and includes a measurement circuit that determines a measure of absolute thoracic impedance using the sensed physiological signal, and a risk circuit that quantifies a risk of worsening heart failure (WHF) for the subject using a comparison of the determined measure of absolute thoracic impedance to a specified threshold value of absolute thoracic impedance, and generate an indication of risk of WHF of the subject according to the quantifying of the risk. | 12-10-2015 |
20160001088 | SYSTEM AND METHOD FOR ANALYZING MEDICAL DEVICE PROGRAMMING PARAMETERS - The technology disclosed herein relates to a system and method for analyzing medical device programming parameters. One aspect of the current technology is a method where an overall performance metric is detected for a cardiac medical device that is outside of a threshold at a first cardiac location in a patient. Processing circuitry identifies a first operating condition and sensing circuitry measures a first sensor response during the first operating condition. An adjustment is proposed to one or more programming parameters of the medical device based on the performance metric, the first operating condition, and the sensor response to the operating condition. | 01-07-2016 |
Qi An, Nashua, NH US
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20140341917 | ANTI-PD-L1 ANTIBODIES AND USES THEREOF - The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer. | 11-20-2014 |
Ran An, West Lafayette, IN US
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20150079621 | Motility-Contrast Imaging for Oocyte and Embryo Viability Assessment - A method and system is provided for evaluating viability of oocytes and embryos comprising imaging an oocyte or embryo using motility contrast imaging; generating temporal contrast and spatial contrast data for the cells; generating a cell viability value as a function of the temporal and spatial contrast data; and comparing the cell viability value to a predetermined value indicative of a cell suitable for use in an in vitro fertilization program. | 03-19-2015 |
20150124259 | Method For Biodynamic Spectroscope Imaging - Systems and methods for imaging small (˜1 mm thick) living biological specimen is provided to enable the generation of functional 3D images of living tissue for evaluating the effect of an external perturbation on the health of the specimen. A fluctuation power spectrum is constructed for each pixel of a holographic 3D image of the specimen over time and subject to the external perturbation. A normalized spectrum of dynamic intensity as a function of frequency is generated for each pixel. The normalized spectra for each pixel is filtered according to a selected frequency range from among characteristic frequencies corresponding to dynamic activity of naturally occurring biological events within the specimen to provide data corresponding only to the dynamic activity associated with the selected frequency range. | 05-07-2015 |
Seong Soo Alexander An, Ithaca, NY US
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20100009388 | DIFFERENTIAL DETECTION OF MULTIMERIC AND MONOMERIC FORMS OF MULTIMER-FORMING POLYPEPTIDES - A method for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide in a biosample includes (a) contacting the biosample to a capturing antibody recognizing an epitope on the multimer-forming polypeptide to capture the monomeric form, multimeric form or monomeric and multimeric forms; (b) contacting the monomeric form, multimeric form or monomeric and multimeric forms captured to a detecting antibody recognizing an epitope identical to or overlapped with the epitope of step (a); and (c) detecting the formation of a multimeric form-detection antibody complex. | 01-14-2010 |
20100021943 | Methods for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide through three-dimensional interactions - The present invention relates to a method for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide in a biosample, which comprises the steps of: (a) preparing a carrier-capturing antibody conjugate by binding a capturing antibody to the surface of a solid phase carrier in a three dimensional manner, wherein the capturing antibody is capable of recognizing an epitope on the multimer-forming polypeptide; (b) preparing a detection antibody, wherein an epitope recognized by the detection antibody is present at a position in the multimer-forming polypeptide to cause a steric hindrance by the capturing antibody bound to its epitope to prevent the binding of the detection antibody to the multimer-forming polypeptide; (c) contacting simultaneously the carrier-capturing antibody conjugate and the detection antibody to the biosample; and (d) detecting the formation of a carrier-capturing antibody-multimeric form-detection antibody complex. | 01-28-2010 |
Songon An, State College, PA US
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20120190620 | METHODS TO IDENTIFY TARGETS AND MOLECULES REGULATING PURINOSOMES AND THEIR USES - The present invention discloses methods to identify targets, pathways and molecules regulating purinosomes and their uses for treating pathophysiological disorders associated with purinosomes. Disclosed are methods related to both label-free cellular assays and fluorescence imaging to confirm the regulatory roles of various targets and molecules in purinosome dynamics. Disclosed are methods to classify molecules and the uses of these molecules for different indications. Specifically, the purinosome-disrupting molecules can be used for improved prevention and treatment of cancer development. | 07-26-2012 |
Stephen H. An, Boston, MA US
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20110047471 | Apparatus and Methods for Associating a User's Activity in Relation to a Physical Location with a Virtual Community - A system permits a user's activity in relation to a physical location to be associated with a virtual community web site and, therefore, with a virtual community created by the web site. Users indicate their presence at, or association with, a physical location by sending messages from their personal communication devices, such as mobile telephones or Internet-connected computers. Users may participate in activities at the locations by sending such messages, accessing location proxy web sites or via virtual communities. An exemplary activity includes a network-connected jukebox. Users may obtain information about music being played on the jukebox. In addition, the jukebox may display information about music being played on other jukeboxes, possibly in other locations. | 02-24-2011 |
20150154635 | System and Method for Interactive Marketing - A system and method of interactive, location-based presentation and advertising that enables users with wireless network addressable communications devices to control multi-media content on network addressable screens and enables marketers to track, monitor and respond to users interactions in real time. A Proxy Gateway directs a network addressable client PC, connected to a digital display, to serve local content or pull content from one or more web servers. A wireless, network addressable device, typically a mobile phone, is used to communicate commands to the physically remote Proxy Gateway. The Proxy Gateway bridges between the communications device and the display by interpreting the commands from the communications device, forwarding them to the client PC which may pull content from the appropriate web server, or display native message content. | 06-04-2015 |
Tae Jin An US
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20150290491 | HANDGRIP - The present invention provides a hand grip comprising: right and left arms in which upper portions thereof are coupled to each other by a rotating shaft so as to rotate around the rotating shaft, thereby approaching each other and being distanced from each other, and lower portions thereof can be held by the hand of a user; and a resilient means for providing an elastic force in the direction obstructing the approaching of the right and left arms. The resilient means comprises spring members symmetrically installed on the front and back sides of the upper portions of the right and left arms, respectively; each of the front and back side spring members comprises a compression spring, and right and left spring support portions interposed therebetween to support the same in a compressible manner; and each of the left spring support portions and the right spring support portions of the front and back side spring members are connected to each other by left and right spring member coupling shafts and interposing the upper portion of the left arm or the upper portion of the right arm therebetween, and are operated in an integrated manner. | 10-15-2015 |
Tonya An, Grand Rapids, MI US
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20110164128 | IMAGE CAPTURE AND EARPIECE SIZING SYSTEM AND METHOD - A method and system for sizing an earpiece include situating a calibration device proximate a user's ear. The user holds an image capture device so as to aim the image capture device at the user's ear. The user then touches and holds a random area of the touch screen display and releases the touch screen display to activate the image capture device and capture an image of the user's ear and the calibration device. The captured image is then analyzed and an earpiece size is determined based on the analysis of the image. | 07-07-2011 |
20120242815 | EAR SIZING SYSTEM AND METHOD - An ear measurement system and method include obtaining an image of an ear and an associated a calibration device, and analyzing the image to determine the size of desired portions of the ear. Such sizing is then used, for example, for fitting an earbud or earbud adapter. | 09-27-2012 |
20150271588 | IMAGE CAPTURE AND EARPIECE SIZING SYSTEM AND METHOD - A method and system for sizing an earpiece include situating a calibration device proximate a user's ear. The user holds an image capture device so as to aim the image capture device at the user's ear. The user then touches and holds a random area of the touch screen display and releases the touch screen display to activate the image capture device and capture an image of the user's ear and the calibration device. The captured image is then analyzed and an earpiece size is determined based on the analysis of the image. | 09-24-2015 |
Vivian An, Portland, OR US
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20150161306 | FAULT INSERTION FOR SYSTEM VERIFICATION - A computer implemented method of modifying a compiled design of an electronic circuit is disclosed. The method includes accessing a stored compilation representing the design, and causing the computer to generate a modified version of the stored compilation in response to an indication of a change to a portion of the design. | 06-11-2015 |
Wei An, Auburndale, MA US
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20110103450 | OFDM CHANNEL ESTIMATION SYSTEM AND METHOD COMPONENTS - Channel estimation for high mobility OFDM channels is achieved by identifying a set of channel path delays from an OFDM symbol stream including carrier data, inter-channel interference noise and channel noise; determining the average channel impulse response for the identified set of channel path delays in each symbol; generating a path delay curvature for each channel path delay in each symbol based on stored average channel impulse responses for the identified channel path delays; estimating the carrier data in the symbols in the OFDM symbol stream in the presence of inter-channel interference noise and channel noise from the OFDM symbol steam and the average impulse responses for the identified channel path delays; reconstructing the inter-channel interference noise in response to the path delay curvature, the identified set of channel path delays and estimated carrier data to produce a symbol stream of carrier data and channel noise with suppressed inter-channel interference noise. | 05-05-2011 |
20110103453 | OFDMCHANNEL ESTIMATION SYSTEM AND METHOD COMPONENTS - Channel estimation for high mobility OFDM channels is achieved by identifying a set of channel path delays from an OFDM symbol stream including carrier data, inter-channel interference noise and channel noise; determining the average channel impulse response for the identified set of channel path delays in each symbol; generating a path delay curvature for each channel path delay in each symbol based on stored average channel impulse responses for the identified channel path delays; estimating the carrier data in the symbols in the OFDM symbol stream in the presence of inter-channel interference noise and channel noise from the OFDM symbol steam and the average impulse responses for the identified channel path delays; reconstructing the inter-channel interference noise in response to the path delay curvature, the identified set of channel path delays and estimated carrier data to produce a symbol stream of carrier data and channel noise with suppressed inter-channel interference noise. | 05-05-2011 |
20110182340 | OFDM CHANNEL ESTIMATION SYSTEM AND METHOD COMPONENTS - Channel estimation for high mobility OFDM channels is achieved by identifying a set of channel path delays from an OFDM symbol stream including carrier data, inter-channel interference noise and channel noise; determining the average channel impulse response for the identified set of channel path delays in each symbol; generating a path delay curvature for each channel path delay in each symbol based on stored average channel impulse responses for the identified channel path delays; estimating the carrier data in the symbols in the OFDM symbol stream in the presence of inter-channel interference noise and channel noise from the OFDM symbol steam and the average impulse responses for the identified channel path delays; reconstructing the inter-channel interference noise in response to the path delay curvature, the identified set of channel path delays and estimated carrier data to produce a symbol stream of carrier data and channel noise with suppressed inter-channel interference noise. | 07-28-2011 |
20110182374 | OFDM CHANNEL ESTIMATION SYSTEM AND METHOD COMPONENTS - Channel estimation for high mobility OFDM channels is achieved by identifying a set of channel path delays from an OFDM symbol stream including carrier data, inter-channel interference noise and channel noise; determining the average channel impulse response for the identified set of channel path delays in each symbol; generating a path delay curvature for each channel path delay in each symbol based on stored average channel impulse responses for the identified channel path delays; estimating the carrier data in the symbols in the OFDM symbol stream in the presence of inter-channel interference noise and channel noise from the OFDM symbol steam and the average impulse responses for the identified channel path delays; reconstructing the inter-channel interference noise in response to the path delay curvature, the identified set of channel path delays and estimated carrier data to produce a symbol stream of carrier data and channel noise with suppressed inter-channel interference noise. | 07-28-2011 |
Wei An, Waltham, MA US
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20100194635 | METHOD AND APPARATUS FOR SOFTWARE GPS RECEIVER - A receiver architecture for processing spread spectrum signals. The receiver has an RF front end to receive and down convert a broadcast signal to an intermediate frequency carrier. The IF signal is digitized and provided to a processor (which may be a software-driven DSP, an ASIC or other embodiment) for processing. A given IF carrier is removed and the signal is low pass filtered. The signal is provided to a number of channels, each, for example, correspond to a unique transmitter. On each channel the sample rate is reduced to a predetermined fixed rate with timing mismatch compensated. The Doppler frequency shift, as estimated for the channel, is removed succeedingly. A locally generated copy of the spreading code used by the transmitter is applied to the carrier and Doppler removed signal at the predetermined fixed sample rate. The de-spread signal is used to provide estimates of the Doppler shift and for subsequent sample selection. Pseudo-range and delta pseudo-range estimates from each channel are used to estimate, for example, the receiver's position. | 08-05-2010 |
Wei An, Newton, MA US
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20110026577 | Equalization for OFDM Communication - The problem of inefficient channel impulse-response processing is addressed by processing different parts of a channel impulse response to accurately locate channel taps, and to generate more than one set of equalization coefficients. This allows the most-suited equalization coefficient to be selected based on a selection criterion. | 02-03-2011 |
20130243131 | REAL-TIME I/Q IMBALANCE CORRECTION FOR WIDE-BAND RF RECEIVER - A receiver apparatus models and corrects the frequency-dependent and the frequency-independent mismatches between I and Q paths jointly by polynomial estimations. The receiver apparatus may sample digitized I and Q path signals. The sampled data point may be modeled in equations with real and imaginary components. The sampled discrete time-domain data may be converted to frequency-domain data. Multiple statistics values based on the frequency-domain data may be computed. Coefficients for the polynomial equations may be estimated based on the computed statistic values. The channel mismatches may be estimated from the polynomial equations and used to compensate the mismatch either on the I path or the Q path. | 09-19-2013 |
20140050251 | METHOD AND APPARATUS FOR SOFTWARE GPS RECEIVER - A receiver architecture for processing spread spectrum signals. The receiver has an RF front end to receive and down convert a broadcast signal to an intermediate frequency carrier. The IF signal is digitized and provided to a processor (which may be a software-driven DSP, an ASIC or other embodiment) for processing. A given IF carrier is removed and the signal is low pass filtered. The signal is provided to a number of channels, each, for example, correspond to a unique transmitter. On each channel the sample rate is reduced to a predetermined fixed rate with timing mismatch compensated. The Doppler frequency shift, as estimated for the channel, is removed succeedingly. A locally generated copy of the spreading code used by the transmitter is applied to the carrier and Doppler removed signal at the predetermined fixed sample rate. The de-spread signal is used to provide estimates of the Doppler shift and for subsequent sample selection. Pseudo-range and delta pseudo-range estimates from each channel are used to estimate, for example, the receiver's position. | 02-20-2014 |
20140213197 | SIGNAL DETECTION USING A WIDE/NARROW-BAND RF TRANSCEIVER - A wide/narrow-band RF transceiver receives a signal in wide-band RF spectrum; a processor analyzes the signal and narrows the bandwidth of the RF transceiver in accordance with a carrier frequency, bandwidth, and RF modulation type of the signal. | 07-31-2014 |
20140270001 | QUADRATURE ERROR DETECTION AND CORRECTION - In an example, there is disclosed a system and method for detecting and correcting error in a quadrature receiver (QR). The QR may include a receiver channel operable to divide a received RF signal into I and Q channels. The receiver channel may include error sources, such as (in sequence) pre-demodulation (PD) error, LO mixer error, and baseband (BB) error. Test tones may be driven on the receiver channel at a plurality of test frequencies, and a quadrature error corrector may be provided to detect error from each source. Upon receiving an RF signal, the quadrature error corrector may apply correction coefficients to correct each source of error in reverse sequence (BB, LO, PD). | 09-18-2014 |
20140270002 | SYSTEM AND METHOD QUADRATURE ERROR DETECTION AND CORRECTION - In an example, there is disclosed a system and method for detecting and correcting error in a quadrature receiver (QR). The QR may include a receiver channel operable to divide a received RF signal into I and Q channels. The receiver channel may include error sources, such as (in sequence) pre-demodulation (PD) error, LO mixer error, and baseband (BB) error. Test tones may be driven on the receiver channel at a plurality of test frequencies, and a quadrature error corrector may be provided to detect error from each source. Upon receiving an RF signal, the quadrature error corrector may apply correction coefficients to correct each source of error in reverse sequence (BB, LO, PD). | 09-18-2014 |
20140273902 | QUADRATURE ERROR CORRECTION USING POLYNOMINAL MODELS IN TONE CALIBRATION - One example embodiment provides a system, apparatus, and method for using polynomial models in tone calibration for quadrature error correction in I/Q receivers. In one example embodiment, method for calibrating an I/Q receiver is provided and includes receiving a first mismatch parameter indicating a mismatch between I and Q channels of the I/Q receiver; and estimating a second mismatch parameter from the first mismatch parameter using a polynomial model. | 09-18-2014 |
20150288549 | SYSTEMS AND METHODS FOR NARROWBAND SIGNAL QUADRATURE ERROR CORRECTION - Apparatus and method for quadrature error correction for narrowband or tone signal are disclosed. An analog circuit receives a modulated signal and processes in-phase signal and quadrature-phase signal in in-phase and quadrature-phase signal paths respectively. A digital signal processor performs discrete Fourier transform on each of the in-phase and quadrature-phase signals and determines statistical parameters responsive to mismatch characteristics to estimate quadrature error correction. | 10-08-2015 |
Weidong An, Williamsville, NY US
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20130243650 | Sterilization Method - A method of sterilizing a material, said method comprising the steps of: a) providing a sterilizing composition comprising (i) peracetic acid and (ii) a stabilizer selected from the group consisting of citric acid, isocitric acid, aconitic acid and propane-1,2,3-tricarboxylic acid; b) introducing such sterilizing composition into a hot gaseous stream to produce a peracetic acid vapor; and c) contacting such peracetic acid vapor with the material to be sterilized. The use of such an organic acid stabilizer results in an unexpected reduction in the amount of residue deposited on the heating surface employed to vaporize the sterilizing composition. | 09-19-2013 |
20150037209 | STERILIZATION METHOD - A method of sterilizing a material, said method comprising the steps of: a) providing a sterilizing composition comprising (i) peracetic acid and (ii) a stabilizer selected from the group consisting of citric acid, isocitric acid, aconitic acid and propane-1,2,3-tricarboxylic acid; b) introducing such sterilizing composition into a hot gaseous stream to produce a peracetic acid vapor; and c) contacting such peracetic acid vapor with the material to be sterilized. The use of such an organic acid stabilizer results in an unexpected reduction in the amount of residue deposited on the heating surface employed to vaporize the sterilizing composition. | 02-05-2015 |
Wenge (david) An, Germantown, MD US
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20120154549 | Adapter and corresponding methods for adding 3D function to a 2D digital camera - A combination of a 3D optical adapter and corresponding digital process methods attached and updated to a conventional 2D digital camera so the digital camera can capture, save and transfer 3D stereoscopic digital images as well. | 06-21-2012 |
20140160242 | Adapter and corresponding methods for adding 3D function to a 2D digital camera - A combination of a 3D optical adapter and corresponding digital process methods attached and updated to a conventional 2D digital camera so the digital camera can capture, save and transfer 3D stereoscopic digital images as well. | 06-12-2014 |
William An, Flushing, NY US
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20110137219 | Method and apparatus to grow hair - A method for growing hair includes the steps of detecting a trigger point in proximity to the area for hair growth, reducing the trigger point in proximity to the area for hair growth, and massaging the area for hair growth. The step of massaging may include manual massaging and may include electronically massaging. | 06-09-2011 |
Xiuli An, Bayside, NY US
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20100323393 | Ordered Assembly of Membrane Proteins During Differentiation of Erythroblasts - Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors. | 12-23-2010 |
20120295285 | Ordered Assembly of Membrane Proteins During Differentiation of Erythroblasts - Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors. | 11-22-2012 |
20130209431 | ISOLATION AND CULTURE OF ERYTHROID PROGENITOR CELLS - Disclosed herein are methods of isolating erythroid progenitor cells from a source of human hematopoietic cells and methods of culturing the isolated erythroid progenitor cells in vitro to produce clinically relevant quantities of erythrocytes. | 08-15-2013 |
Yong-Su An US
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20110227850 | TOUCH SENSING TYPE LIQUID CRYSTAL DISPLAY DEVICE AND METHOD OF FABRICATING THE SAME - A touch sensing type liquid crystal display device includes an array substrate includes an array substrate including a first substrate, a common electrode, a pixel electrode, and a touch sensing unit; a color filter substrate including a second substrate and facing the array substrate; an anti-static layer on an outer side of the second substrate and including an inorganic material and conductive particles; and a liquid crystal layer between the first substrate and an inner side of the second substrate. | 09-22-2011 |
Yu An, Sammamish, WA US
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20100185787 | DYNAMIC CALL HANDLING FROM MULTIPLE ATTACHED DEVICES - Multiple peripheral devices are used for various modes of communication in a unified communication application. Employing standard or custom protocols, connected peripheral devices can be configured automatically and different modes of communication such as audio, video, data, and text, are routed to available or selected peripheral devices. Incoming communication requests can be extended to multiple peripheral devices synchronously and users enabled to switch between peripheral devices seamlessly during a communication session. | 07-22-2010 |
20130195118 | TRANSLATION BETWEEN TELEPHONE DEVICE AND NETWORK CLIENT - Call control messages and audio signals between a telephone device and a computer network telephone client on a computing device can be intercepted. For control messages from the computer network telephone client, the control messages can be translated from a first control protocol to a second control protocol and forwarded to the telephone device. For control messages from the telephone device, the control messages can be translated from the second control protocol to the first control protocol and forwarded to the computer network telephone client. For audio signals from the computer network telephone client, the audio signals can be translated from a first audio protocol to a second audio protocol and forwarded to the telephone device. For audio signals from the telephone device, the audio signals can be translated from the second audio protocol to the first audio protocol and forwarded to the computer network telephone client. | 08-01-2013 |
Zesheng An, Smyrna, GA US
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20080223444 | Perylene Charge-Transport Materials, Methods of Fabrication Thereof, and Methods of Use Thereof - Briefly described, embodiments of this disclosure include perylenetetracarboxylic diimide charge-transport materials, methods of forming perylenetetracarboxylic diimide charge-transport materials, and methods of using the perylenetetracarboxylic diimide charge-transport materials. | 09-18-2008 |
20090044863 | CORONENE CHARGE-TRANSPORT MATERIALS, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF - Briefly described, embodiments of this disclosure include coronene charge-transport materials, methods of forming coronene charge-transport materials, and methods of using the coronene charge-transport materials. | 02-19-2009 |
Zhiqiang An, Houston, TX US
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20160032011 | HER3 SPECIFIC MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE - Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. | 02-04-2016 |
Zhiqiang An, Ambler, PA US
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20090285799 | Antibody Antagonists of Interleukin-13 Receptor Alpha1 - Antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are useful in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed. | 11-19-2009 |
20100166772 | ANTIGEN-BINDING PROTEINS TARGETING S. AUREUS ORF0657n - The present invention features antigen binding proteins that bind to a region found to have an epitope that can be targeted to provide protection against | 07-01-2010 |
20100239597 | Anti-ADDL monoclonal antibody and use thereof - The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42. | 09-23-2010 |
20100272714 | Anti-ADDL Antibodies and Uses Thereof - The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42. | 10-28-2010 |
20100285035 | High Affinity Antibody Antagonists of Interleukin-13 Receptor Alpha 1 - High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed. | 11-11-2010 |
20110052597 | Anti-IL-13R Alpha1 Antibodies and Their Uses Thereof - Antibody antagonists of human interleukin-13 receptor alpha 1 which bind to hIL-13Rα1 through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13 are disclosed herein. These antibodies have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing hIL-13Rα1-mediated activities are also disclosed. | 03-03-2011 |
20110159013 | Anti-ADDL Antibodies and Uses Thereof - The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42. | 06-30-2011 |
20120164158 | Anti-ADDL Monoclonal Antibody and Use Thereof - The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42. | 06-28-2012 |
20120171224 | Anti-ADDL Antibodies and Uses Thereof - The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42. | 07-05-2012 |
20120201835 | ANTIBODIES SPECIFIC FOR DKK-1 - Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis. | 08-09-2012 |
20140056915 | HIGH AFFINITY ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR ALPHA 1 - High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed. | 02-27-2014 |