Patent application number | Description | Published |
20090131416 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR - Certain substituted pyrazinyl amide compounds are histamine H | 05-21-2009 |
20100130485 | Cyclopropyl Amines as Modulators of the Histamine H3 Receptor - Certain cyclopropyl amines are histamine H | 05-27-2010 |
20100274004 | BICYCLIC PIRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS - Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection. | 10-28-2010 |
20100274005 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS - Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection. | 10-28-2010 |
20100280240 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS - Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection. | 11-04-2010 |
20110178062 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR - Certain substituted indole and benzothiophene compounds are histamine H | 07-21-2011 |
20140135311 | TETRAHYDRO-PYRIMIDOAZEPINES AS MODULATORS OF TRPV1 - Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease. | 05-15-2014 |
Patent application number | Description | Published |
20130204091 | ANTERIOR HIP REPLACEMENT RETRACTOR ASSEMBLY - A retractor assembly has a first clamp adapted to be mounted to a table, a first vertically oriented post supported by the clamp, a first main arm mounted for at least one of angular and lateral movement relative to the first post, and lockable in a selected position, and a tree assembly configured at one end of the second post. The tree assembly has at least two accessory arms, with each accessory arm having a first ball joint on a first end, and a pivot lock knob at an immediate portion, and each accessory arm having a second end configured to accept the mounting of a retractor to the accessory arm. The retractor assembly may also include a J-shaped hook mounted to a ratcheting linearly movable distractor assembly and trochanteric retractors mounted to the accessory arms for femoral elevation and exposure. | 08-08-2013 |
20130204262 | SURGICAL PROCESS FOR ANTERIOR HIP REPLACEMENT - Various exemplary embodiments relate to a method of performing an anterior approach hip replacement using a retractor assembly. The method may include: providing a retractor assembly including a first vertical post, a plurality of accessory arms mounted to the first post, a second vertical post, and a femur distractor mounted to the second post; exposing a surgical site including the femoral neck and acetabulum using a plurality of retractors secured to the accessory arms; cutting the femoral neck to remove the femoral head; preparing the acetabulum for insertion of an acetabular cup; preparing the femur for insertion of a femoral implant by lifting the femur using a femur hook and the femur distractor; and closing the surgical site. In various alternative embodiments, the retractors may include a lesser trochanteric retractor coming from a direct medial approach and a greater trochanteric retractor coming from a lateral, posterior, proximal approach. | 08-08-2013 |
20140358149 | SURGICAL PROCESS FOR ANTERIOR HIP REPLACEMENT - Various exemplary embodiments relate to a method of performing an anterior approach hip replacement. The method may include: exposing a surgical site including the femoral neck and acetabulum using a plurality of retractors secured to the plurality of accessory arms; cutting the femoral neck to remove the femoral head; preparing the acetabulum for insertion of an acetabular cup; preparing the femur for insertion of a femoral implant by lifting the femur using a femur hook and the femur distractor; and closing the surgical site. In various alternative embodiments, the method may include using a lesser trochanteric retractor corning from a direct medial approach and a greater trochanteric retractor coming from a lateral, posterior, proximal approach. | 12-04-2014 |
Patent application number | Description | Published |
20100183196 | DYNAMIC TRACKING OF SOFT TISSUE TARGETS WITH ULTRASOUND IMAGES, WITHOUT USING FIDUCIAL MARKERS - An apparatus and method of dynamically tracking a soft tissue target with ultrasound images, without the use of fiducial markers. In one embodiment, the apparatus includes an ultrasound imager to generate a reference ultrasound and a first ultrasound image having a soft tissue target, and a processing device coupled to the ultrasound imager to receive the reference ultrasound image and the first ultrasound image, to register the first ultrasound image with the reference ultrasound image, and to determine a displacement of the soft tissue target based on registration of the first ultrasound image with the reference ultrasound image. | 07-22-2010 |
20110160589 | DYNAMIC TRACKING OF SOFT TISSUE TARGETS WITH ULTRASOUND IMAGES - Apparatus and methods of dynamically tracking a soft tissue target with ultrasound images are described. An apparatus includes an ultrasound imager coupled to a robotic arm. A method includes acquiring a first ultrasound (US) image of a patient with an ultrasound imager, determining a quality metric of the first US image, and adjusting one or more imaging parameters of the ultrasound imager if the quality metric of the acquired first US image is less than a quality threshold. | 06-30-2011 |
20140276539 | Methods and Devices for Pain Management - A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition. | 09-18-2014 |
20140276708 | Methods and Systems for Treatment of Spasticity - A system for alleviating spasticity of a skeletal muscle having an associated motor nerve. The system may include a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween. The needle is configured for insertion proximate to the nerve. A cooling fluid supply lumen can extend distally within the needle lumen to a distal portion of the needle lumen. A cooling fluid source is couplable to the cooling fluid supply lumen to direct cooling fluid flow into the needle lumen. A controller having at least one processor configured to implement a spasticity treatment algorithm for controlling the cooling fluid source so that liquid from the cooling flow vaporizes within the needle lumen to provide a treatment phase to the motor nerve such spasticity of the skeletal muscle is mitigated. | 09-18-2014 |
20140343542 | Methods, Systems, and Devices for Treating Neuromas, Fibromas, Nerve Entrapment, and/or Pain Associated Therewith - A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition. | 11-20-2014 |
20140343543 | Cryogenic Enhancement of Joint Function, Alleviation of Joint Stiffness and/or Alleviation of Pain Associated With Osteoarthritis - A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition. | 11-20-2014 |
20140343544 | Methods and Systems for Treatment of Occipital Neuralgia - A system for alleviating occipital neuralgia. The system has a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween, the needle configured for insertion proximate to a location of the occipital nerve. A cooling fluid supply lumen extends distally within the needle lumen to a distal portion of the needle lumen. A cooling fluid source is coupled to the cooling fluid supply lumen to direct cooling fluid flow into the needle lumen. A controller that has at least one processor configured implements an occipital neuralgia treatment algorithm for controlling the cooling fluid source so that liquid from the cooling flow vaporizes within the needle lumen to provide a treatment phase to location of the occipital nerve such that the occipital neuralgia is mitigated. | 11-20-2014 |
20140350536 | Cryogenic Blunt Dissection Methods and Devices - A point of incision is created within tissue, the tissue having a temporoparietal fascia-deep temporoparietal fascia layer (TPF-sDTF) beneath skin and a temporal branch of a target nerve extending along a portion of the TPF-sDTF, the point of incision being laterally displaced from the target nerve. A cryogenic probe having a distal tip extending from an elongated body is inserted into the point of incision. The TPF-sDTF is bluntly dissected using the cryogenic probe such that a treating portion of the cryogenic probe is directly adjacent to a first treatment portion of the target nerve. The cryogenic probe is activated to create a first treatment zone at the first treatment portion of the target nerve to cause a therapeutic effect. | 11-27-2014 |
Patent application number | Description | Published |
20090041189 | ADAPTIVE X-RAY CONTROL - A method, apparatus and system for measuring the signal-to-noise ratio of x-ray images and to adaptively control x-ray exposure in response to image quality and patient movement. | 02-12-2009 |
20090118722 | METHOD AND APPARATUS FOR COOLING SUBCUTANEOUS LIPID-RICH CELLS OR TISSUE - A system for reducing subcutaneous lipid-rich cells or tissue of a subject is disclosed. The system may include a fluid supply, a probe in fluid communication with the fluid supply, and a coolant circulated between the fluid supply and the probe. The probe may be configured to be inserted into the subject to be at least proximate to the subcutaneous lipid rich cells. The coolant may be at a temperature such that the subcutaneous lipid-rich cells or tissue proximate to the inserted probe are cooled. | 05-07-2009 |
20090252301 | METHOD AND APPARATUS FOR PATIENT LOADING AND UNLOADING - A method and apparatus of a positioning system are described to position an upper-half of a body relative to a head-end of a couch. The positioning system may be a patient positioning system and may include a treatment couch, a leg rest coupled to the treatment couch, and a drive mechanism coupled to the leg rest. The patient positioning system may also include a treatment couch, having a base portion of a treatment couch and plurality of detachable portions of the treatment couch. The plurality of detachable portions to adjust a height of the treatment couch to accommodate differing heights of patients. | 10-08-2009 |
20100081971 | TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATIONS - Methods and system for treatment planning for non- and minimally-invasive alteration of body adipose tissue for reduction and contouring of body fat are described herein. Treatment plans can be generated by capturing current body part data (e.g., positioning, contour/shape, thickness of adipose tissue, etc.), determining desired outcome of treatment (e.g., percent reduction of adipose tissue thickness, degree of contour change, etc.), and determining treatment parameters to achieve desired results. Algorithms can be used to determine best-fit treatment parameters to use in treatment sessions. In some embodiments, the system can provide a predictive end-result image for communication to patient and/or for determining alteration of desired outcome. In various embodiments, real-time monitoring of feedback data can be used to determine treatment plan efficacy. Additional algorithms can provide real-time comparison of feedback data to anticipated feedback data, and can be used to change treatment parameters in real-time to achieve desired effects. | 04-01-2010 |
20100152824 | SYSTEMS AND METHODS WITH INTERRUPT/RESUME CAPABILITIES FOR TREATING SUBCUTANEOUS LIPID-RICH CELLS - Systems for removing heat from a subject's subcutaneous lipid-rich regions, such as tissue, organs, cells, and so forth, are described herein. In various embodiments, the system includes a treatment device and a controller for controlling a treatment process. The controller is configured to detect and compensate for an interruption in the treatment process. | 06-17-2010 |
20100280582 | DEVICE, SYSTEM AND METHOD OF REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS - Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate. | 11-04-2010 |
20110238050 | HOME-USE APPLICATORS FOR NON-INVASIVELY REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS VIA PHASE CHANGE COOLANTS, AND ASSOCIATES DEVICES, SYSTEMS AND METHODS - Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger. | 09-29-2011 |
20110238051 | HOME-USE APPLICATORS FOR NON-INVASIVELY REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS VIA PHASE CHANGE COOLANTS, AND ASSOCIATED DEVICES, SYSTEMS AND METHODS - Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger. | 09-29-2011 |
20120213333 | ADAPTIVE X-RAY CONTROL - Controlling the timing of acquiring x-ray images based on target movement. | 08-23-2012 |
20130158440 | TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATION - Methods and system for treatment planning for non- and minimally-invasive alteration of body adipose tissue for reduction and contouring of body fat are described herein. Treatment plans can be generated by capturing current body part data (e.g., positioning, contour/shape, thickness of adipose tissue, etc.), determining desired outcome of treatment (e.g., percent reduction of adipose tissue thickness, degree of contour change, etc.), and determining treatment parameters to achieve desired results. Algorithms can be used to determine best-fit treatment parameters to use in treatment sessions. In some embodiments, the system can provide a predictive end-result image for communication to patient and/or for determining alteration of desired outcome. In various embodiments, real-time monitoring of feedback data can be used to determine treatment plan efficacy. Additional algorithms can provide real-time comparison of feedback data to anticipated feedback data, and can be used to change treatment parameters in real-time to achieve desired effects. | 06-20-2013 |
20130245731 | SYSTEMS AND METHODS WITH INTERRUPT/RESUME CAPABILITIES FOR TREATING SUBCUTANEOUS LIPID-RICH CELLS - Systems for removing heat from a subject's subcutaneous lipid-rich regions, such as tissue, organs, cells, and so forth, are described herein. In various embodiments, the system includes a treatment device and a controller for controlling a treatment process. The controller is configured to detect and compensate for an interruption in the treatment process. | 09-19-2013 |
20140257443 | DEVICE, SYSTEM AND METHOD OF REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS - Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate. | 09-11-2014 |
Patent application number | Description | Published |
20090312754 | METHOD AND APPARATUS FOR MEASURING CATHETER CONTACT FORCE DURING A MEDICAL PROCEDURE - A method for measuring the contact force exerted on tissue by a probe for heating the tissue and containing an antenna which is connected to a radiometer whose output reading indicates the temperature at depth of the tissue contacted by the probe comprises displaying the output reading of the radiometer, applying sufficient power to the probe to heat the tissue to a selected first temperature that is not lethal to the tissue, moving the probe into contact with the tissue, observing the increase in the displayed temperature reading that occurs when the probe contacts the tissue, and advancing the probe toward the tissue until the displayed temperature reading reaches a value corresponding to a selected tissue contact force. After the probe position in the tissue has stabilized, the applied power to the probe may be increased to heat the tissue to a selected second temperature that is lethal to tissue for a sufficient time to ablate the tissue followed by lowering the tissue heating to a sub-lethal temperature. Apparatus for practicing the method is also disclosed. | 12-17-2009 |
20100185191 | METHOD AND APPARATUS FOR ALIGNING AN ABLATION CATHETER AND A TEMPERATURE PROBE DURING AN ABLATION PROCEDURE - Apparatus for aligning an ablation catheter and a temperature probe relatively for an ablation procedure includes an ablation catheter with a first antenna for ablating tissue at an ablation site in a patient's body and a temperature probe for placement in a body passage having a wall portion adjacent to the ablation site so that a second antenna in the probe is positioned opposite the first antenna. A microwave source provides a pulse modulated microwave signal to one of the antennas and a radiometer is in circuit with the other antenna. A synchronizing device in circuit with the microwave source and the radiometer enables the radiometer to synchronously detect the microwave signal so that the radiometer provides an alignment signal whose strength reflects the degree of alignment of the first and second antennas which signal may be used to control an alignment display. An alignment method using the apparatus is also disclosed. | 07-22-2010 |
20110176578 | Devices and Methods for Exercise Monitoring - The disclosure relates to methods and devices for monitoring e.g., fatigue levels by measuring a subject's body core temperature. In one embodiment, microwave radiometry is used to measure such core temperature. | 07-21-2011 |
20120283534 | DUAL MODE TEMPERATURE TRANSDUCER WITH OXYGEN SATURATION SENSOR - Apparatus for detecting intracranial temperature and blood oxygenation includes a transducer having a working surface for placement against a patient's cranium. The transducer forms a microwave antenna having walls defining an aperture having a pair of opposite broader boundaries and a pair of opposite narrower boundaries at the working surface. The antenna is tuned to a frequency which produces a first output signal indicative of heat emanating from the cranium. An oxygen saturation sensor sharing that aperture includes a radiation emitter located at one of narrower boundaries which directs electromagnetic radiation across the aperture to a radiation detector at the other of the narrower boundaries and which produces a corresponding second output signal. A control unit includes a display and a processor for processing the signals to calculate an intracranial temperature and an oxygen saturation value for display by the control unit. | 11-08-2012 |
20140012132 | HEATING/SENSING CATHETER APPRATUS FOR MINIMALLY INVASIVE APPLICATIONS - Catheter apparatus comprises a coaxial cable having proximal and distal ends. The cable includes a hollow center conductor, an outer conductor and an electrically insulating layer between the conductors. An antenna is at the distal end of the cable, and a diplexer is connected to the cable, the diplexer including a transmit path for connecting the antenna to a transmitter which transmits first frequency signals and a receive path for connecting the antenna to a receiver which detects second frequency signals the diplexer isolating the signals on the two paths from one another. A transmission line connects the cable to the diplexer, the transmission line having a segment with a tubular inner conductor one end of which is connected to the center conductor and a second end of which is adapted for connection to a coolant source, the center and inner conductors forming a continuous coolant pathway. | 01-09-2014 |
20140018697 | HEATING/SENSING CATHETER APPARATUS FOR MINIMALLY INVASIVE APPLICATION - Catheter apparatus comprises a coaxial cable having proximal and distal ends. The cable includes a hollow center conductor, an outer conductor and an electrically insulating layer between the conductors. An antenna is at the distal end of the cable, and a diplexer is connected to the cable, the diplexer including a transmit path for connecting the antenna to a transmitter which transmits first frequency signals and a receive path for connecting the antenna to a receiver which detects second frequency signals the diplexer isolating the signals on the two paths from one another. A transmission line connects the cable to the diplexer, the transmission line having a segment with a tubular inner conductor one end of which is connected to the center conductor and a second end of which is adapted for connection to a coolant source, the center and inner conductors forming a continuous coolant pathway. | 01-16-2014 |
20140343374 | LOW PROFILE TEMPERATURE TRANSDUCER - A low profile temperature transducer has a working surface for placement against a body surface and a first output. The transducer is a flat laminate composed of alternating conductive and dielectric layers. The laminate defines at least one slotline antenna for exposure to the body surface to pick up thermal emissions from the underlying tissue at depth. A feed network having a characteristic impedance is connected to the first output and a slotline-to-stripline transition is connected between the at least one antenna and the feed network, the transition providing a match between the impedance at the at least one antenna and the characteristic impedance. Also, a temperature sensor may be present at the working surface to detect the body surface temperature under the transducer, that surface temperature being used to calculate actual temperature at depth. | 11-20-2014 |
20150092817 | APPARATUSES FOR NON-INVASIVELY SENSING INTERNAL TEMPERATURE - A transducer for noninvasively determining an internal temperature of a location of interest in a body of a subject may be configured to receive native temperature signals originating from the location of interest without substantially receiving interfering signals. Such a transducer may include one or more shielding features for preventing interference. In addition, such a transducer may include a dielectric cavity configured or positioned to increase the native temperature signals sensed, or received, by the antenna. A transducer may be configured to multiplex signals that are indicative of a temperature of a location of interest within the body of a subject and reference temperature signals. Such a transducer may include a connector that facilitates the communication of a multiplexed signal, such as a connector for a coaxial cable. The connector of a transducer may be configured to swivel relative to an end of a cable that has been coupled thereto. Systems including such a transducer are also disclosed. | 04-02-2015 |
20150094608 | SYSTEMS AND METHODS OF NON-INVASIVELY DETERMINING INTERNAL TEMPERATURE - A system for and noninvasively monitoring temperature within a body of a subject includes a transducer and an interface unit. The transducer receives native temperature signals, which are electromagnetic signals. One or both of the transducer and the interface unit convert the native temperature signals to a standard temperature signal. The interface unit may be configured to be coupled to a standard temperature signal-receiving apparatus, such as a standard vital signs monitor or a standard body temperature management system, which may recognize the standard temperature signal. Methods for noninvasively monitoring temperature, including receiving native temperature signals and converting the native temperature signals to a standard temperature signal, are also disclosed. | 04-02-2015 |
20150342676 | SYSTEMS AND METHODS OF MEASURING TEMPERATURE OF TISSUE DURING AN ABLATION PROCEDURE - The present invention provides systems and methods for radiometrically measuring temperature during ablation. An interface module includes a processor; a first input/output (I/O) port configured to receive digital radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port configured to receive ablative energy from an electrosurgical generator; a temperature display; a patient relay in communication with the first and second I/O ports and the processor; and a computer-readable medium storing radiometer and thermocouple operation parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the operation parameters, causing the temperature display to display the calculated temperature, and closing the patient relay so as to pass ablative energy received on the second I/O port to the first I/O port. | 12-03-2015 |
20160038229 | TISSUE CONTACT DETECTION PRIOR TO AND DURING AN ABLATION PROCEDURE - The present invention provides systems and methods for radiometrically measuring temperature and detecting tissue contact during ablation. An interface module includes a first input/output (I/O) port for receiving radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port for receiving ablative energy from an electrosurgical generator; a temperature display; a patient relay; a computer-readable medium storing radiometer and thermocouple parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the parameters; causing the temperature display to display the calculated temperature; closing the patient relay to pass ablative energy from the second to the first I/O port; determining whether the ICT is in contact with tissue based on the radiometer signal. An output device indicates whether the ICT is determined to be in contact with the tissue. | 02-11-2016 |