Alessandra
Alessandra Badari, Vedano Al Lambro (mb) IT
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20120178770 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS - Pyrimidinylpyrrolopyridinone derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 07-12-2012 |
20130345245 | SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS - Pyrimidinylpyrrolopyridinone derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 12-26-2013 |
20140005150 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | 01-02-2014 |
Alessandra Badari, Torino IT
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20110144068 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS - 3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. | 06-16-2011 |
Alessandra Barabino, Genova IT
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20100272588 | ENERGY RECOVERY SYSTEM IN A GAS COMPRESSION PLANT - A system for recovering energy in a gas compression plant. The system comprises at least one centrifugal compressor configured to suck the gas, at a certain inlet pressure, from a suction conduit and configured to deliver the gas, at a certain outlet pressure that is greater than an inlet pressure, through a delivery conduit The system also includes at least one gas recirculation system configured to redirect the gas from the delivery conduit to the suction conduit when the gas flow rate entering into the compressor is below a certain limit value. In the portion of the plant arranged downstream of the compressor, at least one turbo-expander and at least one valve are installed in parallel so that they cooperate with each other and are controlled by electronic devices so as to protect the compressor and to produce useful energy during recirculation mode. | 10-28-2010 |
Alessandra Bartolozzi, Somerville, MA US
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20100144707 | Pharmacokinetically improved compounds - The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease. | 06-10-2010 |
Alessandra Bartolozzi, Norwalk, CT US
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20100076029 | Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 03-25-2010 |
20100081644 | Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 04-01-2010 |
20110071196 | Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 03-24-2011 |
20110136869 | Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 06-09-2011 |
20110312932 | Therapeutic Uses of Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 12-22-2011 |
20110312944 | Heterocyclic Compounds Which Modulate The CB2 Receptor - Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 12-22-2011 |
20120010184 | Therapeutic Uses of Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 01-12-2012 |
20120202793 | RHO KINASE INHIBITORS - The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins. | 08-09-2012 |
20120214787 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I): | 08-23-2012 |
20120220561 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compound of formula (I): | 08-30-2012 |
20120245162 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I): | 09-27-2012 |
20120295896 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compounds of formula (I) and (IA): | 11-22-2012 |
20120316173 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR - Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 12-13-2012 |
20130030022 | Compounds Which Selectively Modulate The CB2 Receptor - Compounds of formula (I) | 01-31-2013 |
20130131047 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease. | 05-23-2013 |
20130196967 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION - The present invention relates to compound of formula (I): | 08-01-2013 |
Alessandra Benicchio, Lainate IT
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20090275542 | AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS - Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms. | 11-05-2009 |
Alessandra Biffi, Milan IT
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20120128643 | GENE VECTOR - A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell. | 05-24-2012 |
Alessandra Blasina, San Diego, CA US
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20090312280 | COMBINATION THERAPY OF (2R,Z)-2-AMINO-2-CYCLOHEXYL-N-(5-(1-METHYL-1H-PYRAZOL-4-YL)-1-OXO-2,6-DIH- YDRO-1H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-8-YL)ACETAMIDE - The present invention relates to novel combination therapies of (2R,Z)-2-amino-2-cyclohexyl-N-(5-(1-methyl-1H-pyrazol-4-yl)-1-oxo-2,6-dihydro -1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide (compound 1), a pharmaceutically acceptable salt thereof, or a mixture thereof, in combination with an anti-cancer agent or radiation therapy. | 12-17-2009 |
20110165170 | OSTEOPONTIN ANTIBODIES - The present disclosure provides isolated antibodies, particularly human antibodies, or antigen binding portions thereof, that bind to osteopontin with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. | 07-07-2011 |
Alessandra Bontempi Di Roccaspada, Trieste IT
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20110061563 | NOVEL ENVIRONMENTAL FRIENDLY ANTI-MICROBIAL ADHESION AGENTS FOR ANTI-FOULING PAINTS AND ANTI-FOULING PAINTS CONTAINING THEM - An ecologically compatible anti-microbial-adhesion agent is described, which is particularly suitable for use in anti-fouling paints, preferably for boats, characterized in that it comprises a compound selected from eugenol, vanillin, benzaldehyde substituted with one or two substituents selected from the groups —OH (hydroxy) and —OCH | 03-17-2011 |
Alessandra Boschi, Bologna IT
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20080267868 | Radiopharmaceutical for diagnostic imaging containing a technetium-99m nitride heterocomplex - A process for diagnostic imaging of heart or adrenal glands of a human being comprises administering to the human being a radiopharmaceutical containing as an active ingredient a technetium-99m nitride heterocomplex comprising technetium-99m nitride and two different ligands coordinated therewith, i.e., a bisphosphinoamine compound and a bidentate ligand and represented by the formula (1): [ | 10-30-2008 |
Alessandra Braccini, Basel CH
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20080318315 | Reverse-Flow Perfusion of Three-Dimensional Scaffolds - The invention is a reverse-flow method and system for the loading, proliferation and differentiation of cells into and throughout an implantable biocompatible three-dimensional scaffold. | 12-25-2008 |
Alessandra Casano, Redwood City, CA US
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20100209929 | MULTIPLE MECHANISMS FOR MODULATION OF JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 08-19-2010 |
Alessandra Chianale, Alpignano IT
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20110146272 | DIESEL ENGINE FOR A MOTOR VEHICLE - A diesel engine is provided for a motor vehicle. The engine includes, but is not limited to a long route exhaust gas recirculating (LR-EGR) system, in which a Lean NO | 06-23-2011 |
20110153260 | METHOD FOR DIAGNOSING A CATALYTIC DEVICE OF AN ENGINE EXHAUST GAS AFTER-TREATMENT SYSTEM - A method is provided for estimating an aging index of the catalytic device. There estimation of the aging index includes, but is not limited to determining the catalytic device operating temperature, determining an aging factor as a function of at least the determined operating temperature, determining the time period spent by the catalytic device at the determined operating temperature, calculating a contributing aging coefficient as a function of the aging factor and the time period, and increasing a cumulative aging parameter by adding the contributing aging coefficient. | 06-23-2011 |
20110203262 | DEVICE FOR REDUCING NOX EMISSION IN A DIESEL ENGINE SYSTEM - A device is provided for reducing NOx emission in the engine exhaust stream for a Diesel engine system. The engine system including, but not limited to an exhaust line having at least a Diesel Oxidation Catalyst (DOC), a Diesel Particulate Filter (DPF) and a Selective Catalyst Reduction (SCR) system. Inside the Diesel Particulate Filter (DPF) a NOx absorber is provided and the NOx absorber being suitable to store the NOx at low temperature and subsequently release the NOx when a target temperature is reached. | 08-25-2011 |
20120185153 | METHOD FOR MANAGING THE TRANSITION BETWEEN TWO COMBUSTION MODES IN AN INTERNAL COMBUSTION ENGINE - A method is disclosed for managing the transition between a lean combustion mode and a rich combustion mode, or vice versa. After a regeneration demand, or at the end of the regeneration phase, the air mass flow is modified from a first set point to a new set point within a predetermined time depending on the engine conditions. An air mass percentage value is cyclically calculated and compared with a target value. When the target value is reached, the fuel path is then suddenly switched to compensate the torque change due to different combustion modes and to achieve the desired rich or lean condition. | 07-19-2012 |
Alessandra Cirani Almgren, Brooklyn, NY US
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20120019564 | Methods, Systems, and Media for Presenting Works of Art to a Viewer - Methods, systems, and media for presenting works of art to a viewer are provided. In accordance with some embodiments, methods for presenting works of art to a viewer are provided, the methods comprising: receiving, at a hardware processor programmed to do so, a plurality of images that each represent a different one of a plurality of physical works of art; receiving, at a hardware processor programmed to do so, size information for each of the plurality of physical works of art; presenting an image representing a physical object on a display; and presenting at least a portion of each of at least some of the plurality of images on the display with sizes scaled according to the relative sizes of the corresponding physical works of art compared to the size of the physical object. | 01-26-2012 |
Alessandra Cirla, Varese IT
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20090099221 | PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE-AND FURANE-DERIVATIVES AS KINASE INHIBITORS - The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R | 04-16-2009 |
20120295906 | PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE-AND FURANE-DERIVATIVES AS KINASE INHIBITORS - The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R | 11-22-2012 |
20140336192 | 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS - There are provided substituted 3-phenyl-isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. | 11-13-2014 |
20150051237 | PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE- AND FURANE-DERIVATIVES AS KINASE INHIBITORS - The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R | 02-19-2015 |
Alessandra Di Cianni, Pistoia IT
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20110136741 | DICARBA-ANALOGUES OF OCTREOTIDE - Analogues of octreotide, their preparation and use are described. | 06-09-2011 |
Alessandra Eustaquio, Solana Beach, CA US
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20090325208 | Biosynthesis of Salinosporamide A and Analogs and Methods Thereof - The present invention relates to a sahnosporamide A composition and methods of making salinosporamide A and analogs thereof. The present invention also relates to methods of identifying 2OS proteasome inhibiting agents. | 12-31-2009 |
Alessandra Ferlini, Ferrara IT
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20120225791 | ARRAY-BASED METHOD FOR DETECTION OF COPY NUMBER VARIATIONS IN THE HLA LOCUS FOR THE GENETIC DETERMINATION OF SUSCEPTIBILITY OF DEVELOPMENT OF VENOUS MALFORMATIONS IN THE EXTRACRANIAL SEGMENTS OF THE CEREBROSPINAL VEINS AND KIT THEREOF - Method for in vitro diagnosis of susceptiblility of developing venous malformations i the extracranial segment of the cerebrospinal veins in a patient comprising the detection of copy number variations (CNVs) in chromosome 6p21 in a sample of genomic DNA of the patient, wherein the venous malformations are associated with the development of multiple sclerosis. | 09-06-2012 |
Alessandra Fernicola, Roma IT
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20120033348 | MULTILAYER COMPOSITE GETTER - A multilayer composite getter, a method for its manufacturing and electrochemical devices for energy storage employing said multilayer composite getters are described. | 02-09-2012 |
Alessandra Fernicola, Lainate Mi IT
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20130202921 | MULTI-LAYER COMPOSITE GETTER - A multi-layer composite getter is described. Also described is a method for the manufacturing of the multi-layer composite getter and electrochemical devices for energy storage that employ the multi-layer composite getter. | 08-08-2013 |
Alessandra Fischetti, Milano IT
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20120071365 | Detection Device Having Increased Detection Rate, and Method for Quick Detection of Biological Molecules - A biological molecule detection device that includes a detection array, arranged on a body and having one or more probes for detecting corresponding electrically charged molecules, wherein a time varying electric field generating circuit is provided for generating at least one time varying electric field around the detection array within the detection region. The time varying electric field moves the electrical charged molecules repeatedly back and forth over the probes, thus providing increased opportunities for interaction and speeding the detection process. | 03-22-2012 |
Alessandra Frizzi, Westerly, RI US
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20080229456 | Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 09-18-2008 |
20090013434 | Recombinant DNA constructs and methods for controlling gene expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 01-08-2009 |
Alessandra Frizzi, Davis, CA US
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20090246350 | Corn Seed Comprising Novel Opaque Modifiers and Related Methods - Novel corn opaque modifier loci, associated molecular markers and methods for obtaining the loci, markers, and resultant seed are provided. Vitreous seed with reduced alpha-zein storage protein content that contain the opaque modifier loci are also described. Processes for obtaining milled corn seed products from the vitreous seed with reduced alpha-zein storage protein content that contain the opaque modifier loci are also provided. | 10-01-2009 |
20100223694 | Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 09-02-2010 |
20100269224 | Multiple Virus Resistance in Plants - The present invention provides gene targets, constructs and methods for the genetic control of plant disease caused by multiple plant viruses. The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences of plant-parasitic viruses. Protein-expression based approaches may also be utilized to augment phenotype resistance. Thus, transcription of a single transgenic event comprising one or more plant expression cassettes can allow for broad spectrum resistance of a plant to multiple plant viral strains and species among the | 10-21-2010 |
20110035838 | Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 02-10-2011 |
20110035839 | Recombinant DNA Constructs and Methods for Controlling Gene Expression - The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy. | 02-10-2011 |
20120227131 | Transgenic plants with enhanced agronomic traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 09-06-2012 |
20130198902 | MULTIPLE VIRUS RESISTANCE IN PLANTS - The present invention provides gene targets, constructs and methods for the genetic control of plant disease caused by multiple plant viruses. The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences of plant-parasitic viruses. Protein-expression based approaches may also be utilized to augment phenotype resistance. Thus, transcription of a single transgenic event comprising one or more plant expression cassettes can allow for broad spectrum resistance of a plant to multiple plant viral strains and species among the geminiviruses, tospoviruses, and potexviruses. | 08-01-2013 |
Alessandra Gaiba, Essex GB
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20100022650 | Benzamide Derivatives As EP4 Receptor Agonists - A compound of formula (I) or a pharmaceutically acceptable derivative thereof, | 01-28-2010 |
20100179168 | ARYL AND HETEROARYL SULPHONAMIDES AS GROWTH HORMONE SECRETAGOGUE RECEPTOR AGONISTS - The present invention therefore provides compounds of formula (I) or pharmaceutically acceptable salts thereof: (I) processes for their preparation, pharmaceutical compositions containing the same and to their use in the treatment of gastrointestinal and other disorders. | 07-15-2010 |
20100305166 | NOVEL COMPOUNDS - A compound of formula (I) or salts thereof, | 12-02-2010 |
Alessandra Gambacurta, Roma IT
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20100068189 | Method for Expanding Adult Stem Cells from Blood and Compositions and Methods for Using the Same - A method for the expansion of adult stem cells from blood, particularly but not only peripheral blood, involves removing adult stem cells from blood of a mammal, immediately expanding the stem cells via in-vitro treatment with MCSF (Macrophage Colony Stimulating Factor) at a concentration of about 8-15 nM, and purifying the expanded stem cells. Compositions and methods of using the expanded adult stem cells are also described. | 03-18-2010 |
20110017733 | KIT FOR COLLECTING BLOOD, PREFERABLY PERIPHERAL BLOOD, FOR THE PRODUCTION OF STEM CELLS - A kit for collecting blood, preferably peripheral blood, for the production of pluripotent stem cells comprises at least a first container, able to contain the blood taken, which contains an anticoagulant and the substance MCSF (Macrophage Colony Stimulating Factor). | 01-27-2011 |
20120308535 | Pharmaceutical Composition Containing Expanded Adult Stem Cells and Methods of Using Same for Treatment - A method for the expansion of adult stem cells from blood, particularly but not only peripheral blood, involves removing adult stem cells from blood of a mammal, immediately expanding the stem cells via in-vitro treatment with MCSF (Macrophage Colony Stimulating Factor) at a concentration of about 8-15 nM, and purifying the expanded stem cells. Compositions and methods of using the expanded adult stem cells are also described. | 12-06-2012 |
Alessandra Gerli, Leiden NL
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20090260767 | USE OF HYDROPHOBIC DYES TO MONITOR HYDROPHOBIC CONTAMINANTS IN A PAPERMAKING PROCESS - A method of monitoring and controlling one or more types of hydrophobic contaminants in a papermaking process is disclosed. The methodology utilizes the measurement of hydrophobic dyes, which are capable of fluorescing and interacting with the hydrophobic contaminants. In addition, a method of determining the relative size of the hydrophobic contaminants is disclosed as well. | 10-22-2009 |
20100236732 | USE OF FLUORESCENCE TO MONITOR HYDROPHOBIC CONTAMINANTS IN A PAPERMAKING PROCESS - A method of monitoring and controlling one or more types of hydrophobic contaminants in a papermaking process is disclosed. The methodology utilizes the measurement of dyes, which are capable of fluorescing and interacting with the hydrophobic contaminants. | 09-23-2010 |
Alessandra Giorgetti, Barcelona ES
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20110044961 | Generation of Induced Pluripotent Stem Cells from Cord Blood - Methods and compositions for the generation and use of genetically corrected induced pluripotent stem cells are provided. | 02-24-2011 |
Alessandra Giuliano Albo, Torino IT
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20130196924 | BIOMARKERS FOR DIAGNOSING AND DETECTING THE PROGRESSION OF NEURODEGENERATIVE DISORDERS, IN PARTICULAR OF AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to biomarkers, to their use and to a method for diagnosing in vitro or detecting the progression of a neurodegenerative disease in an individual, in particular for Amyotrophic Lateral Sclerosis (ALS). The method comprises the steps of isolating a biological sample from the individual; quantifying the level of one or more polypeptides in the biological sample according to the invention; comparing the obtained level with a reference level. | 08-01-2013 |
20140030734 | Biomarkers for Diseases of the Central Nervous System - The present invention describes a method of diagnosis and/or progression of a disease based on the detection and quantification of the expression levels of biomarkers preferably selected from the group comprising gelsolin isoforms (SEQ. ID 1 and 2) and Vitamin D binding protein isoforms (SEQ. ID 3 and 4). Said method is applied to central nervous system diseases, preferably to Multiple Sclerosis. | 01-30-2014 |
Alessandra Guarinoni, Piacenza IT
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20080244974 | Fluid Mixing Device Inserted in or Combined With a Reactor - A device is described for mixing two fluids, inserted in or combined with a reactor, which can also be used for catalytic partial oxidation, substantially consisting of the following zones:—a first feeding zone equipped with means for allowing a first fluid, possibly gaseous under the operating conditions, to enter in an axial direction;—an underlying distribution zone containing a bundle of pipes preferably parallel to the axis inside which said fluid is uniformly distributed;—a second feeding zone equipped with means for allowing a second fluid to enter the distribution zone containing the bundle of preferably parallel pipes and to be uniformly distributed outside said parallel pipes;—a mixing zone separated from the distribution zone by a pipe-plate supporting said parallel pipes, said pipe-plate having slits or openings in order to uniformly discharge the second fluid in an axial direction into the mixing area, and said parallel pipes extending beyond said pipe-plate into the mixing zone. | 10-09-2008 |
20090127512 | ENHANCED PROCESS FOR THE PRODUCTION OF SYNTHESIS GAS STARTING FROM OXYGENATED COMPOUNDS DERIVING FROM BIOMASSES - The present invention relates to a catalytic partial oxidation process for the production of synthesis gas starting from oxygenated compounds deriving from biomasses, comprising at least the following operative phase: reacting, in a suitable reactor, a reaction mixture comprising: a) one or more oxygenated compounds selected from glycerine, ethanol, triglycerides of fatty acids, carbohydrates having the general formula C | 05-21-2009 |
20100294994 | PROCESS FOR THE PRODUCTION OF SYNTHESIS GAS AND HYDROGEN STARTING FROM LIQUID OR GASEOUS HYDROCARBONS - A process is described for producing synthesis gas and hydrogen starting from liquid hydrocarbon feedstocks, possibly also mixed with gaseous hydrocarbon streams, comprising at least the following operations: 1) nebulizing/vaporizing a stream of a liquid hydrocarbon feedstock consisting of one or more of the following hydrocarbons: naphthas, various kinds of gas oils, such as LCO, HCO and VGO, other products of refining cycles and oil up-grading, such as DAO, other heavy residues, at a N temperature ranging from 50 to 500° C. and a pressure of 2 to 50 atm, the nebulization also being effected with the help of a gaseous propellant, possibly with the addition of CO | 11-25-2010 |
20130028815 | PROCESS FOR THE PRODUCTION OF SYNTHESIS GAS AND HYDROGEN STARTING FROM LIQUID OR GASEOUS HYDROCARBONS - An apparatus, containing: (I) an inlet section into which a liquid and optionally a gaseous reagent stream is fed, the inlet section containing a device, which nebulizes and/or vaporizes the liquid stream, the device optionally utilizing vapor and/or a gaseous hydrocarbon stream as propellant; (II) a mixing section containing a chamber having a cylindrical or truncated-conical geometry, which mixes the reagent stream exiting the inlet section (I), to form a reaction mixture; (III) a reaction section including i) a first structured catalytic bed a ii) a structured catalytic bed heating device, in which the reaction mixture exiting the mixing section (II) flows through each layer of the first structured catalytic bed with a contact time varying from 0.01 to 10 ms, to produce a mixture of reaction products; and IV) a cooling section of the mixture of reaction products leaving the reaction section (III). | 01-31-2013 |
20130129609 | CATALYTIC SYSTEM FOR CATALYTIC PARTIAL OXIDATION PROCESSES WITH A SHORT CONTACT TIME - The present invention relates to a catalytic system comprising at least two catalytic zones of which at least one zone exclusively contains one or more noble metals selected from the group consisting of Rhodium, Ruthenium, Iridium, Palladium and Platinum and at least another zone contains Nickel, said catalytic system characterized in that at least one zone exclusively containing noble metals selected from the group consisting of Rhodium, Ruthenium, Iridium, Palladium and Platinum is always distinct but in contact with at least one zone containing Nickel. One or more metals selected from the group consisting of Rhodium, Ruthenium, Iridium, Palladium and Platinum are possibly added to the catalytic zone or zones comprising Nickel. | 05-23-2013 |
Alessandra Lazzarotti, Massa IT
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20120316323 | NEW PROCESS FOR THE INDUSTRIAL-SCALE PURIFICATION OF GAMMA GLOBULINS FROM HUMAN PLASMA FOR INDUSTRIAL APPLICATIONS - The invention relates to a novel, industrial-scale process for the purification of gamma-immunoglobulins (IgG) starting from plasma or fractions thereof. The method involves two chromatographic steps, i.e. a cation exchange capture chromatography, and then a polishing anion exchange chromatography, ensuring a highly purified end product, which contains no aggregates, and high yields. The process also involves a virus inactivation step by means of a solvent/detergent treatment to inactivate the viruses with a lipid envelope, and a virus removal step by nanofiltering to ensure the removal of the non-enveloped viruses. | 12-13-2012 |
Alessandra Luzzago, Rome IT
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20080286275 | Antigen Binding Proteins Directed Against Scavenger Receptor B1 that Inhibit Hcv Replication - The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4. | 11-20-2008 |
20090233992 | HEPATITIS C VIRUS VACCINE - The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV. | 09-17-2009 |
Alessandra Macchietti, Rome IT
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20100208875 | SERVICE DELIVERY PLATFORM DOCKING STATION - A service delivery platform (SDP) docking station (DS) is part of a multiple layer service delivery platform implementation. The SDP DS adds a second SDP layer between the end user and the Core SDP. The Core SDP implements the process flows that enable, provision, and execute telecommunications products and services. The SDP DS provides a customizable front end to the Core SDP to provide local service provider customization, flexible local selection and activation of products and services, and other features. | 08-19-2010 |
20100211563 | Cross Community Invitation and Multiple Provider Product Information Processing System - A telecommunications system implements a cross platform invitation mechanism. The system receives a search query from a subscriber, retrieves location information of the subscriber, and retrieves a search result from multiple information sources based on the search query. The system returns the search result to the subscriber, receives a search result selection from the search result from the subscriber, and builds a contact information list from community data associated to the subscriber and obtained from multiple contact sources. The contact information list may include, for example, friends or other contacts for the subscriber. The system returns the contact information list to the subscriber, receives a contact selection from the contact information list from the subscriber; and transmits an invitation message based on the contact selection to recipients corresponding to the contact selection. The recipients may return an ‘accept’ or ‘deny’ response to the system, which notifies the subscriber accordingly. | 08-19-2010 |
Alessandra Mallano, Roma IT
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20120282257 | SINGLE-CHAIN VARIABLE FRAGMENT (SCFV) ABLE TO RECOGNIZE AND BIND CD99 HUMAN PROTEIN - The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. | 11-08-2012 |
Alessandra Maroni, Luvinate IT
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20110250238 | SYSTEM FOR THE COLON DELIVERY OF DRUGS SUBJECT TO ENZYME DEGRADATION AND/OR POORLY ABSORBED IN THE GASTROINTESTINAL TRACT - Said invention refers to a pharmaceutical form for selective colon delivery of drugs or bioactive molecules degraded and/or poorly absorbed in the gastrointestinal tract. The system comprises a core consisting of the active ingredient, and a protease inhibitor layer and/or an absorption enhancer layer, said core being separated from these layers by means of a polymer that swells and/or dissolves and/or is degraded when in contact with the biological fluids present in the gastro-intestinal tract; depending on the thickness of the polymeric layer, the release of the drug can be modulated with respect to the inhibitor and/or promoter. | 10-13-2011 |
Alessandra Masci, Rome IT
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20120079495 | MANAGING ACCESS TO A SHARED RESOURCE IN A DATA PROCESSING SYSTEM - Processes requiring access to shared resources are adapted to issue a reservation request, such that a place in a resource access queue, such as one administered by means of a semaphore system, can be reserved for the process. The reservation is issued by a Reservation Management module at a time calculated to ensure that the reservation reaches the head of the queue as closely as possible to the moment at which the process actually needs access to the resource. The calculation may be made on the basis of priority information concerning the process itself, and statistical information gathered concerning historical performance of the queue. | 03-29-2012 |
20120185865 | MANAGING ACCESS TO A SHARED RESOURCE IN A DATA PROCESSING SYSTEM - Processes requiring access to shared resources are adapted to issue a reservation request, such that a place in a resource access queue, such as one administered by means of a semaphore system, can be reserved for the process. The reservation is issued by a Reservation Management module at a time calculated to ensure that the reservation reaches the head of the queue as closely as possible to the moment at which the process actually needs access to the resource. The calculation may be made on the basis of priority information concerning the process itself, and statistical information gathered concerning historical performance of the queue. | 07-19-2012 |
Alessandra Pasquarello, Verona IT
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20100063078 | SPIROCOMPOUNDS USEFUL AS MODULATORS FOR DOPAMINE D3 RECEPTORS - The present invention relates to novel compounds of formula (I) or salts thereof: | 03-11-2010 |
20100063097 | Azabicyclo [3.1.0] Hexane Derivatives as Modulators of Dopamine D3 Receptors - The present invention relates to certain azabicyclic compounds of formula (I)′: | 03-11-2010 |
20100069416 | Azabicyclo [3.1.0] Hexyl Derivatives as Modulators of Dopamine D3 Receptors - The present invention relates to certain azabicyclo compounds of formula (I)′: | 03-18-2010 |
20100240661 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS - The present invention relates to novel compounds of formula (I) or a salt thereof: | 09-23-2010 |
20120022056 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS - Compounds of formula (I) wherein R | 01-26-2012 |
Alessandra Pastacaldi, Rosignano Solvay-Livorno IT
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20080289972 | Method of Purifying an Aqueous Solution - Method of purifying an aqueous solution comprising iodide, calcium and magnesium ions, according to which in a first step the solution is alkalized in order to precipitate calcium and magnesium, which are separated out, and in a second step the aqueous solution from the separation is oxidized in order to oxidize the iodide ions to iodine that is removed over a basic halogenated anion exchange resin, the exchange resin being regenerated by using a portion of the aqueous solution from the separation. | 11-27-2008 |
20090288957 | Process for the Production of Sodium Bicarbonate - Process for the joint production of sodium carbonate and sodium bicarbonate out of sesquicarbonate, in which the sesquicarbonate is dissolved in water, in order to form a feed water solution comprising both sodium carbonate and sodium bicarbonate, in which at least part of the feed water solution is introduced into all the compartments of an electrodialyser and in which a sodium bicarbonate enriched solution and a sodium carbonate enriched solution are extracted from the compartments. | 11-26-2009 |
20110031130 | Method for purifying aqueous compositions - Method for purifying an aqueous composition by removing silicon therefrom, according to which a compound comprising aluminum is added to the aqueous composition in order to obtain a molar aluminum content greater than the molar silicon content in said composition, the pH of the composition is controlled and maintained at a value higher than or equal to 8 and lower than or equal to 10, and the precipitate formed is separated from the aqueous suspension obtained. | 02-10-2011 |
Alessandra Pedarzini, Finale Emilia IT
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20100192956 | METHOD FOR MANUFACTURING A CUFF ON PLASTIC TUBE PROVIDED WITH AN EXTERNAL SHEATH - Method for manufacturing a cuff on a plastic tube comprising an inner tube and an outer sheath covering said inner tube. The outer sheath comprises at least a portion to be molded for producing a cuff. The method comprises a covering step including an injection operation in which air is intermittently or continuously injected between the inner tube and sheath. | 08-05-2010 |
20100194001 | DIE FOR MOLDING OF A CUFF ON A PLASTIC TUBE - A die for molding a cuff on a plastic tube, including an upper shell and a lower shell defining a molding cavity between them; each of the shells has an external structure and an internal wall for defining a half of the molding cavity and for defining a hollow space with the external structure. The molding cavity and hollow spaces are separated from each other by internal walls. The die includes openings which are connected with the molding cavity and the hollow spaces respectively. | 08-05-2010 |
20120204883 | Transtracheal Catheter Apparatus - A catheter apparatus ( | 08-16-2012 |
20120266891 | SYSTEM FOR TRANSTRACHEAL ADMINISTRATION OF OXYGEN - A system for transtracheal administration of supplemental oxygen to a patient in need of continuous long tem oxygen therapy comprising a cannula ( | 10-25-2012 |
Alessandra Pedarzini, Finale Emilia(mo) IT
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20090301479 | FILTER AND/OR HME DEVICE FOR RESPIRATORY CIRCUITS COMPRISING A CONDENSATION TRAP - A filter and/or HME device including an upper shell suitable to be connected to ventilation means, a lower shell suitable to be connected to a tracheal or tracheostomy tube of a patient, a filter and/or HME element disposed between the upper shell and the lower shell and a condensation screen disposed in front of the filter and/or HME element and facing the lower shell wherein the condensation screen has a conical wall extending from the opposite part of the filter and/or HME element to produce, together with a portion of the lower shell a collection chamber for the condensation that forms. | 12-10-2009 |
Alessandra Polara, Basel CH
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20110112080 | OXAZOLINE DERIVATIVES - The invention relates to compounds of formula I | 05-12-2011 |
20120108609 | DIHYDROOXAZOL-2-AMINE DERIVATIVES - The invention relates to compounds of formula | 05-03-2012 |
20120295900 | 1,3-OXAZINES AS BACE 1 AND/OR BACE2 INHIBITORS - The present invention provides compounds of formula I | 11-22-2012 |
20130345241 | DIHYDROOXAZOL-2-AMINE DERIVATIVES - The invention relates to compounds of formula | 12-26-2013 |
Alessandra Restivo, Milano (mi) IT
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20120220592 | 2-PHENYLETHYLAMINO DERIVATIVES AS CALCIUM AND/OR SODIUM CHANNEL MODULATORS - 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented. | 08-30-2012 |
Alessandra Restivo, Milano IT
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20080319057 | 2-Phenylethylamino Derivatives as Calcium and/or Sodium Channel Modulators - 2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R | 12-25-2008 |
20100210631 | SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS - Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly used for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital, and gastrointestinal diseases. | 08-19-2010 |
20110046129 | 2-Phenylethylamino Derivatives as Calcium and/or Sodium Channel Modulators - 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented. | 02-24-2011 |
20130274249 | SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS - Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases. | 10-17-2013 |
20130289122 | SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS - Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases. | 10-31-2013 |
Alessandra Rotunno, Rome IT
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20090187547 | Comprehension of Digitally Encoded Texts - Methods, computer program products and systems for facilitating computer-assisted user comprehension of digitally encoded texts. In one embodiment of the present invention, the user is provided with the ability to perform multiple searches with different dictionaries or search engines, according to the user's needs. The user has the option of marking the words (or sentences) with several different symbols or colors or text highlighting and associating each of these marking to a specific dictionary or search engine. Searches of each of the selected text portions is performed within the associated dictionary databases, and the user is provided with the results of the searches for facilitating comprehension of the text. | 07-23-2009 |
20140135036 | Proximity Based Reminders - Mechanisms, in a data processing system, for generating a reminder notification are provided. The physical presence of another device within a physical local range of a wireless communication device is detected. An identity associated with the other device is determined and a determination is made as to whether a reminder record is stored in association with the identity associated with the other device. In response to a reminder record being stored in association with the identity associated with the other device, a reminder notification is generated and output on the wireless communication device based on content of the reminder record. | 05-15-2014 |
Alessandra Sambugaro, Vicenza IT
Alessandra Sette, La Jolla, CA US
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20100099613 | PEPTIDES FOR INDUCING A CTL AND/OR HTL RESPONSE TO HEPATITIS C VIRUS - The present invention is directed to peptides, and nucleic acids encoding them, derived from the Hepatitis C Virus (HCV). The peptides are those which elicit a CTL and/or HTL response in a host. The invention is also directed to compositions and vaccines for prevention and treatment of HCV infection and diagnostic methods for detection of HCV exposure in patients. | 04-22-2010 |
Alessandra Simonelli, Mantova IT
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20090068354 | Process for Improving the Insulating Capacity of Expanded Vinyl Aromatic Polymers and the Products thus Obtained - Process for improving the insulating capacity of expanded vinyl aromatic which comprises: | 03-12-2009 |
20100148110 | COMPOSITE MATERIAL BASED ON VINYLAROMATIC POLYMERS HAVING ENHANCED THERMAL INSULATION PROPERTIES AND PROCESS FOR THE PREPARATION THEREOF - Expandable particle composite material suitable for the preparation of expanded materials having a density lower than 40 g/l and a content of closed cells of at least 60%, including heterophase cavities and/or heterophase domains, whose matrix is a synthetic thermoplastic resin having at least 60% by weight of a vinyl aromatic polymer and in which an expanding system is contained, together with a heterogeneously distributed graphite material, having a graphitization degree, calculated by means of the Maire and Mering formula, of at least 0.2. | 06-17-2010 |
20110020542 | PROCESS FOR IMPROVING THE INSULATING CAPACITY OF EXPANDED VINYL AROMATIC POLYMERS AND THE PRODUCTS THUS OBTAINED - Process for improving the insulating capacity of expanded vinyl aromatic which includes: | 01-27-2011 |
20120184636 | PROCESS FOR THE PREPARATION OF EXPANDABLE VINYL AROMATIC POLYMERS WITH A REDUCED THERMAL CONDUCTIVITY BY POLYMERIZATION IN SUSPENSION - Process for the preparation of beads of expandable vinyl aromatic polymers by means of polymerization in aqueous suspension, which comprises polymerizing at least one vinyl aromatic monomer in aqueous suspension in the presence of a peroxide initiator system, active at a temperature higher than 800 C, an expanding agent, and in the presence of:—an amide having the general formula R | 07-19-2012 |
20130225703 | COMPOSITIONS OF SELF-EXTINGUISHING EXPANDABLE VINYL AROMATIC (CO)POLYMERS AND PROCESS FOR THEIR PREPARATION - Compositions based on self-extinguishing expandable vinyl aromatic polymers in granules comprising: a. a polymeric matrix and, homogeneously englobed in the polymeric matrix, b. 3-10% by weight, calculated with respect to the polymer (a), of an expanding system; c. 0.005-5% by weight, calculated with respect to the polymer (a), of a brominated flame-retardant agent; d. 0.001-2% by weight, calculated with respect to the polymer (a), of a synergic additive; e. 0.005-5% by weight, calculated with respect to the polymer (a), of at least one stabilizing additive selected from: i. pyrophosphates of alkaline or alkaline earth metals, an ammonium group or a unit deriving from melamine; ii. melamine polyphosphate; iii. partially or completely salified polycarboxylic acids; iv. citrates of alkaline or alkaline earth metals; v. polyfunctional alcohols with 2 or more alcohol functions; vi. esters of poly-functional alcohols. | 08-29-2013 |
Alessandra Sllvestri, Capriva Del Friuu IT
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20110200597 | SIGNAL PATHWAY ALTERATIONS AND DRUG TARGET ELEVATIONS IN PRIMARY METACHRONOUS METASTATIC COLORECTAL CANCER COMPARED TO NON-METASTATIC DISEASE - The present invention relates to the identification and diagnostic use of biomarkers in primary colorectal cancer tumors whose activation level are predictive of the likelihood of the onset of metastatic disease. These biomarkers may be used to determine the suitability of a patient for aggressive and/or targeted treatments. Kits and compositions of the invention are also provided. | 08-18-2011 |
Alessandra Suardi, Falconara Marittima IT
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20080221740 | Method for Estimating The Food Temperature Inside a Refrigerator Cavity And Refrigerator Using Such Method - A method of controlling the temperature inside a cavity of a cooling appliance provided with a temperature sensor inside the cavity and with an actuator for adjusting the cooling capacity of the appliance, the food temperature is estimated on the basis of a value from the temperature sensor and on a predetermined function of a status of the actuator. | 09-11-2008 |
Alessandra Tacca, Cressa (no) IT
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20120186982 | MODIFIED TUNGSTEN OXIDE AND PROCESS FOR ITS PREPARATION - The present invention relates to a modified tungsten oxide having an atomic concentration of 0.5 to 7.0%, preferably from 2.0 to 5.0%, of nitrogen atoms in lattice position, with respect to the total number of atoms of the oxide, having a surface morphology, detectable by means of a scanning electron microscope, characterized by nanostructures in the form of vermiform or branched open swellings, preferably having a length ranging from 200 to 2,000 nm, and a width ranging from 50 to 300 nm, having an appearance similar to Rice Krispies. The present invention also relates to a process for the preparation of the above oxide by the anodization of metallic tungsten, and also a photoanode comprising the above oxide. | 07-26-2012 |
Alessandra Topai, Rome IT
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20100158796 | AMIDES OF HYALURONIC ACID AND THE DERIVATIVES THEREOF AND A PROCESS FOR THEIR PREPARATION - An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (1).: wherein R═NR | 06-24-2010 |
Alessandra Vailati, Seregno (mi) IT
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20080214846 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 09-04-2008 |
20080216562 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 09-11-2008 |
20080269504 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 10-30-2008 |
Alessandra Verdina, Roma IT
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20090181418 | PEPTIDE ABLE TO BREAK THE M-P53/P63, M-P53/P73 AND M-P53/RESPECTIVE ISOFORM PROTEINS COMPLEX FORMED IN THE TUMOR CELLS AND USES THEREOF IN THE PHARMACOLOGICAL FIELD - The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that has formed in the nucleus of tumor cells. Furthermore, the present invention relates to a method for causing the breakage of said proteinic complexes existing in the tumor cell lines in vitro. The present invention further relates to the use of said peptides for the preparation of a pharmaceutical composition for treating human tumors. | 07-16-2009 |
Alessandra Vitaliti, Bedigliora CH
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20090181023 | Nogo-a binding with enhanced affinity and pharmaceutical use thereof - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG or human NiG-D20 or human NogoA_342-357 with a dissociation constant <1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of nerve repair; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with nerve repair | 07-16-2009 |
20110008334 | NOGO-A BINDING WITH ENHANCED AFFINITY AND PHARMACEUTICAL USE THEREOF - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG or human NiG-D20 or human NogoA_342-357 with a dissociation constant, 1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a nerve repair, a pharmaceutical composition comprising said binding molecule; and a method of treatment of nerve repair; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with nerve repair. | 01-13-2011 |
20110059110 | ANTIBODY (11C7) ANTI NOGO-A AND ITS PHARMACEUTICAL USE - This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant, 1000 nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair, a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair. | 03-10-2011 |
Alessandra Vitaliti, Oberwill CH
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20110027284 | NOGO-A BINDING MOLECULES AND PHARMACEUTICAL USE THEREOF - The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system. | 02-03-2011 |
Alessandra Zamporlini, Pantalla Di Todi (pg) IT
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20120305570 | FAST FREEZER FOR BAGS WITH DETECTION OF THE BAG TEMPERATURE - A freezer for fluids inside bags comprises a freezing chamber ( | 12-06-2012 |