52nd week of 2011 patent applcation highlights part 42 |
Patent application number | Title | Published |
20110318682 | TONER, DEVELOPER, TONER CARTRIDGE, AND IMAGE FORMING APPARATUS - Provided is a toner wherein when a solid image formed by the toner is irradiated with incident light at an incident angle of −45° using a goniophotometer, a ratio (A/B) of a reflectance A at a light-receiving angle of +30° to a reflectance B at a light-receiving angle of −30° is about 2 or more and about 100 or less. | 2011-12-29 |
20110318683 | TONER, DEVELOPER, TONER CARTRIDGE, AND IMAGE FORMING APPARATUS - A toner contains a binder resin and a polyalkylene, wherein the following formula is satisfied: | 2011-12-29 |
20110318684 | MAGENTA TONER FOR LIGHT FIXING, DEVELOPER FOR ELECTROSTATIC IMAGE, DEVELOPER CARTRIDGE, AND IMAGE FORMING APPARATUS - A magenta toner contains a binder resin; at least one selected from a diimonium compound represented by the following general formula (1) and an aminium compound represented by the following general formula (2); and a monomethylquinacridone: | 2011-12-29 |
20110318685 | METHOD FOR CONTROLLING A TONER PREPARATION PROCESS - A method of making toner particles, including mixing at least one emulsion of at least one resin, a colorant, an optional wax, and optional additives to form a slurry; heating the slurry to form aggregated particles in the slurry; freezing aggregation of the particles by adjusting the pH; and heating the aggregated particles in the slurry to coalesce the particles into toner particles. | 2011-12-29 |
20110318686 | POSITIVE PHOTOSENSITIVE RESIN COMPOSITION - The present invention provides a positive photosensitive resin composition, including an alkali soluble phenolic resin; an alkali soluble acrylic resin; and a photosensitive compound having quinone diazide. The positive photosensitive resin composition is applicable to a semi-additive process for forming tiny and fine wirings. | 2011-12-29 |
20110318687 | ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION AND PATTERN FORMING METHOD USING THE COMPOSITION - Provided is an actinic ray-sensitive or radiation-sensitive resin composition including: (A) a resin capable of increasing the solubility in an alkali developer by the action of an acid, (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, and (C) a resin which contains (c) a repeating unit having at least one polarity conversion group and has at least either a fluorine atom or a silicon atom. | 2011-12-29 |
20110318688 | SALT, ACID GENERATOR AND RESIST COMPOSITION - The present invention is a salt represented by the formula (I) | 2011-12-29 |
20110318689 | LIGHT-SENSITIVE LITHOGRAPHIC PRINTING PLATE MATERIAL - An object of the present invention is to provide a light-sensitive lithographic printing plate material having high sensitivity, generating no background stain even when development is carried out by using a neutral developing solution having a pH of less than 9, or an alkali developing solution having a pH in the range of 9 to 12, generating no background stain even when the plate is allowed to stand after developing treatment or during printing for a long period of time, and having excellent in printing endurance and ink transfer property, | 2011-12-29 |
20110318690 | COMPOUND, RESIN AND PHOTORESIST COMPOSITION - The present invention provides a compound represented by the formula (I): | 2011-12-29 |
20110318691 | RESIST COMPOSITION FOR SEMICONDUCTOR, AND RESIST FILM AND PATTERN FORMING METHOD USING THE SAME - An embodiment of the composition contains any of compounds of general formula (I) below: | 2011-12-29 |
20110318692 | PHOTOACTIVE COMPOUND AND PHOTOSENSITIVE RESIN COMPOSITION CONTAINING THE SAME - The present invention relates to a photoactive compound of a novel structure represented by Chemical Formula 1 below | 2011-12-29 |
20110318693 | ACTINIC-RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION, AND RESIST FILM AND PATTERN FORMING METHOD USING THE SAME - An embodiment of the composition contains a resin (P) containing a repeating unit (A) that is configured to decompose when exposed to actinic rays or radiation to thereby generate an acid. The repeating unit (A) contains a cation structure with a monocyclic or polycyclic heterocycle containing a nitrogen atom. | 2011-12-29 |
20110318694 | Source-collector module with GIC mirror and tin vapor LPP target system - A source-collector module (SOCOMO) for generating a laser-produced plasma (LPP) that emits EUV radiation, and a grazing-incidence collector (GIC) mirror arranged relative to the LPP and having an input end and an output end. The LPP is formed using an LPP target system having a light source portion and a target portion, wherein a pulsed laser beam from the light source portion irradiates Sn vapor from a Sn vapor source of the target portion. The GIC mirror is arranged relative to the LPP to receive the EUV radiation at its input end and focus the received EUV radiation at an intermediate focus adjacent the output end. A radiation collection enhancement device may be used to increase the amount of EUV radiation provided to the intermediate focus. An EUV lithography system that utilizes the SOCOMO is also disclosed. | 2011-12-29 |
20110318695 | ARBITRARY PATTERN DIRECT NANOSTRUCTURE FABRICATION METHODS AND SYSTEM - Methods of producing a nanostructure in a target film are provided. The method includes selectively irradiating at least one focusing element of a near-field focusing array that is in near-field focusing relationship with a target film in a manner sufficient to produce a nanostructure from the target film. Also provided are systems for practicing methods of the invention, as well as objects produced thereby. | 2011-12-29 |
20110318696 | ILLUMINATION OPTICAL SYSTEM AND OPTICAL SYSTEMS FOR MICROLITHOGRAPHY - An imaging optical system for microlithography is used to illuminate an object field ( | 2011-12-29 |
20110318697 | GROUND FLARE - Provided is a ground flare in which a low-frequency vibration generated from a ground flare tower, such as a chimney, is properly adjusted to suppress it below a fixture-vibration generation limit, thereby preventing surrounding objects from resonating and vibrating. In a ground flare that burns a flammable exhaust gas with a burner at the lower end of a chimney, in which the lower end of the chimney and the periphery of the burner are surrounded by a windbreak, the low-frequency-noise sound pressure level of a ground flare tower composed of the chimney and the windbreak is reduced by selecting at least one of changing a natural frequency generated from the ground flare tower, using multiple ground flare towers, and installing a low-frequency-vibration absorber in the ground flare tower. | 2011-12-29 |
20110318698 | ZERO WATER DISCHARGE OVEN COOLING - A tunnel oven and method for heating transported carbonaceous material includes an enclosure with a passage having a first and second length and an interconnection between the first and second length. A transport device in the passage moves solid carbonaceous material through and along the first length of the passage. A water cooling mechanism along the second length of the passage and a cooling controller operatively coupled to the cooling mechanism to provide a quantity of water for cooling the carbonaceous material to a temperature below the oxidation temperature of the carbonaceous material in air and above the boiling point of the water so that the quantity of water is completely vaporized to form steam and the carbonaceous material is discharged at the cooled temperature without any liquid water discharge. | 2011-12-29 |
20110318699 | SELF-LIGATING BRACKETS FOR ORTHODONTICS - Self-ligating bracket for orthodontics has a base, an occlusal wall extending from the base and occlusal ligature wing, a gingival wall extending from the base and gingival ligature wing, a slot, which separates the occlusal wall and the gingival wall from one another and extends continuously in the direction from mesial to distal, and a slide, which is held in a guide provided in the occlusal wall and/or in the gingival wall, and in the guide can be shifted in the gingival-occlusal direction, between a closed position, in which the slide bridges the slot, and a open position, in which the slot is open in labial direction, that can hold the slide in its closed position as well as in its open position. Elongated recess, longitudinal direction of which runs parallel to the longitudinal direction of the slot and a strand is arranged horizontally. | 2011-12-29 |
20110318700 | Method and Apparatus for Dental Thermal Sensitivity Tester - A method and apparatus for a dental thermal sensitivity tester have been disclosed. A dental wand has an end that is positionable against a dental feature and has a thermal generation unit in thermal communication with the dental wand end. | 2011-12-29 |
20110318701 | DENTAL PROBE - A dental probe according to the invention is provided with a tip portion including a water flow path, an air flow path, a multi-lumen tube including a duct formed therein in which an optical fiber is inserted, and the optical fiber inserted in the duct. The optical fiber includes a resin-coated layer provided on an outer circumference of a cladding and a metal-coated layer provided on the outer circumference of the resin-coated layer, and the resin-coated layer is formed of a polymer compound having a refractive index lower than that of the cladding. | 2011-12-29 |
20110318702 | Dental Shield Apparatus - A dental shield apparatus includes a first portion of flexible tubing having proximal and distal ends. A handle is operably coupled to the distal end of the first portion of flexible tubing. The dental shield apparatus includes a transparent shield. Second and third portions of flexible tubing operatively couple the transparent shield to the handle, the second portion of flexible tubing having a mass per unit length that is less than a mass per unit length of the first portion of flexible tubing. The third portion of flexible tubing includes a mass per unit length that is less than the mass per unit length of the first portion of flexible tubing. The proximal end of the first portion of flexible tubing is attached to an anchor. | 2011-12-29 |
20110318703 | DENTURE GRINDING MACHINE - A denture grinding machine includes: a denture-holding table for holding dentures; a grinding tool for grinding the dentures held on the denture-holding table; a main body for holding the grinding tool; a moving mechanism for causing relative movement between the denture-holding table and the main body; and a driving mechanism for relatively driving the main body and the denture-holding table. The moving mechanism moves relatively the denture-holding table and the main body in three-dimensional coordinate directions based on grinding portion data, and the grinding tool performs grinding of the denture occlusal surface from a direction perpendicular to the occlusal surface. | 2011-12-29 |
20110318704 | Endosseus implant for use in a jaw cavity and template for making the cavity - An endosseous jaw implant for insertion into a cavity formed in a jaw bone has a central implant body onto which at least one anchor wing is integrally molded. The anchor wing has a wedge-shaped cross section, and at least a front edge and/or a back face or an axis of the center of gravity of the anchor wing extends secantally away from the implant body. | 2011-12-29 |
20110318705 | Hydro clean auto floss - The Hydro Clean Auto Floss provides a molded mouth-guard type mouthpiece configured in a U shape to conform to the contours of a set of human teeth, having a trough to receive the teeth, further comprising an irrigation water flow component at the front thereof consisting of an attachable tubing apparatus, allowing users to floss all of the teeth by means of pressurized water, at once, whether at home or on the go. A series of small circular openings are positioned along the perimeter of the mouthpiece, serving as the egress for water. At the front of the mouthpiece is positioned the attachment point for the irrigation water flow component. The irrigation water flow component comprises one central inlet nozzle, and two outlet nozzles, positioned on each side of the inlet nozzle. All of these nozzles are designed to receive tubing by means of a force fit. At the opposite end of the inlet hose is a spout adapter that is configured to accommodate most sink faucets. | 2011-12-29 |
20110318706 | DENTAL IMPLANT, A DENTAL IMPLANT KIT AND A METHOD OF SECURING A DENTAL BRIDGE TO THE JAW OF THE PATIENT - The application relates to an implant for insertion into a structure, a method for connecting a superstructure to the implant, and a kit comprising the implant and a superstructure. The implant can include a body having an external surface for apposition to bone, an apical end and a coronal end, an insertion interface at the coronal end for engagement with an insertion tool and for inserting the implant in an insertion direction, a connection interface adapted to connect the implant to a connection interface of a superstructure, and a retraction interface for engagement with a retraction member when the superstructure is positioned for connection to the connection interface and being configured for retracting the implant from an applied position in a retraction direction. | 2011-12-29 |
20110318707 | DENTAL IMPLANT HAVING A RECESSED SURFACE FOR SEALING - Apparatus is provided that includes a dental implant having a central longitudinal axis, a lateral external surface, and a distal implant portion that extends from a distal implant end along up to 50% of a longitudinal length of the implant. The implant being shaped so as to define a lumen therethrough having (a) at least one distal opening through a distal external surface of the distal implant portion, and (b) a lateral opening open to the lateral external surface. The implant is also shaped so as to define a recessed surface that (a) is recessed from the lateral external surface, (b) is outside of the lumen, and (c) completely surrounds the lateral opening. Other embodiments are also described. | 2011-12-29 |
20110318708 | CERAMIC DENTAL IMPLANT - A dental implant is disclosed comprising an anchoring part for anchoring within a bone and comprising a mounting part for receiving a prosthetic build-up construction, wherein the anchoring part and the mounting part are configured integrally of a material comprising zirconia, wherein at least the anchoring part is treated at its outer surface at least partially by a subtractive, removing process, such as by sand blasting or is provided with a coating which facilitates an ossification. | 2011-12-29 |
20110318709 | ARTIFICIAL TOOTH - An artificial tooth where an occlusal surface is formed by grinding has a reference point that represents a position and an angle of the artificial tooth when an occlusal surface of the artificial tooth is obtained by an occlusal-surface form measuring apparatus. The reference point is a convexed spherical surface or a concaved spherical surface arranged on the occlusal-surface. The spherical surface is 3 or more. The convexed spherical surface is fit to the concaved spherical surface when the maxillary artificial tooth and mandibular artificial tooth are occluded. The occluding portion of the artificial tooth has a grinding portion. | 2011-12-29 |
20110318710 | TWO-PIECE DENTAL ABUTMENT SYSTEM - The present inventions is an abutment for use with a dental implant. The abutment comprises a prosthetic portion adapted to support a prosthesis thereon and an insert. The prosthetic portion has a subgingival end and a supragingival region for protruding beyond gingiva adjacent to the dental implant. The prosthetic portion has a passageway extending therethrough. The passageway includes an enlarged retention groove and non-round section. The insert extends into the passageway and engages the subgingival end of the prosthetic portion. The insert includes flexible retention fingers that, upon insertion into the passageway, initially contract before reaching the enlarged retention groove and then expand outwardly into the enlarged retention groove to hold the insert onto the prosthetic portion. The insert also has a non-round section for mating with the non-round section of the passageway. | 2011-12-29 |
20110318711 | IMPLANT PROSTHETIC PART SET AND METHOD OF MANUFACTURING REPLICATION PLASTER MODEL INCLUDING ABUTMENT USING THE SAME - Provided are an implant prosthetic part set and a method of manufacturing replication plaster model including an abutment using the same, which can take an impression of the location and the shape of a fixture in an oral cavity without using a typical impression copping, in order to manufacture an upper prosthesis coupled to the fixture implanted into an alveolar bone. | 2011-12-29 |
20110318712 | METHOD FOR CLEANING THE ORAL CAVITY - A method for cleaning an oral cavity by positioning a device suitable for detecting and removing plaque from a surface within the oral cavity having applied thereto a fluorescent agent capable of binding to plaque on the surface, substantially simultaneously cleaning and irradiating the surface with a light of a wavelength effective to provide a fluorescent emission when contacted with the fluorescent agent, collecting at least a portion of the fluorescent emission over a predetermined first time period (PTP1), determining an average plaque value (APV) based on the fluorescent emission collected over the PTP1, comparing the APV to a predetermined plaque value (PPV), and continuing to substantially simultaneously clean and irradiate the surface within the oral cavity for a predetermined second time period (PTP2). | 2011-12-29 |
20110318713 | METHOD FOR CLEANING THE ORAL CAVITY - A method of cleaning an oral cavity, the method including positioning a device suitable for detecting and removing plaque from a surface of the oral cavity within the oral cavity, cleaning and irradiating the surface of a tooth in the oral cavity, the tooth having applied thereto a fluorescent agent, with incident radiation of a wavelength effective to provide a fluorescent emission when contacted with the fluorescent agent on the tooth, collecting at least a portion of the fluorescent emission over a first time period, determining a first average fluorescent emission value (APV1), collecting at least a portion of the fluorescent emission over a second time period, determining a second average plaque value (APV2); and comparing the APV1 to the APV2. | 2011-12-29 |
20110318714 | IMPLANT MATERIAL AND METHOD FOR MANUFACTURING THE SAME - An implant material includes a base material, and a silicon-containing carbon thin film formed on a surface of the base material. The carbon thin film contains a C—C component in which carbon atoms are bonded, and a SiC component in which carbon and silicon atoms are bonded, and a ratio of the SiC component is 0.06 or higher. | 2011-12-29 |
20110318715 | RECOIL IMPULSE GENERATOR FOR A WEAPON SIMULATOR - The invention relates to a recoil impulse generator for a weapon simulator comprising a force storage element and an impulse mass that can be moved and that is moved from a stressed to an unstressed position with a triggering element is actuated in order to simulate a recoil impulse. The recoil impulse generator comprises a drive that drives a spindle uniterruptedly during a shot sequence simulating several shots; a coupling that is connected to the impulse mass and to the force storage element and that engages in the spindle in an engaged state and that is moved along the spindle by means of rotation of the spindle in order to bring the impulse mass into the stressed position again the force applied by the force storage element; a disengaging means that switches the coupling to a disengaged state when the impulse mass has reached the stressed position; and an engaging means that switches the coupling to the engaged state when the impulse mass has reached the unstressed position. | 2011-12-29 |
20110318716 | SYSTEM AND METHOD TO MEASURE EFFECTIVENESS OF BUSINESS LEARNING - The invention generally describes learning solutions and related methods for managing the learning and training needs of an organization in a manner that is responsive to dynamic business timelines, goals and strategic objectives. Business goals are determined through examination of existing business data sources, so as to tailor learning solutions to business impacts. Accurate computations of return on training investment are provided to allow accurate assessment of the effectiveness of training programs. Also disclosed are networks of learning platforms that together implement the learning solution by providing electronic tools and information sharing capabilities needed by a learning solution services provider to efficiently implement and manage learning efforts according to the business desires of a complex learner organization, while receiving organization performance data in order to compute and report performance measurements. | 2011-12-29 |
20110318717 | Personalized Food Identification and Nutrition Guidance System - A user presents a food item to a device. In response, the device provides the user with advice about whether or not to eat the food item. The advice is also based on personalized food preferences or restrictions and medical conditions of the user. The advice may also be based on food-related data obtained from other users, such as personalized food preferences, restrictions, medical conditions, and food intake histories of such users. The user may accept or reject the advice provided to the user by the system. If the user rejects the advice, the device may identify one or more alternative food items within the vicinity of the device or any other location requested by the user and provide the user with advice about whether or not to eat the alternative food items. The user may accept or reject this alternative advice. | 2011-12-29 |
20110318718 | BARTENDING KIT AND METHOD - The present invention is a kit and method allowing a user to make a multitude of mixed drinks from a limited amount of drinkable alcohol. The kit includes various standard bartending tools and an instruction set for teaching the user how to make mixed drinks. The present invention reduces the costs associated with stocking a personal bar, while also simplifying the learning of mixology. | 2011-12-29 |
20110318719 | MULTI-USER HEADSET TEACHING APPARATUS - Acoustical voice-feedback systems include headsets connected through a connector or central hub for vocalizing and sound formation assistance. A user's voice is conveyed directly into his or her own ear as well as the ears of each connected user. A central hub allows selective connection of one or more headsets to each other, or allows an instructor to selectively connect an instructor headset to one or more instructee headsets. | 2011-12-29 |
20110318720 | Potty training device for boys - A potty training device for use on toilets has a target releasably attached to a bent rod which is pivotally attached to a clamping means. The clamping means clamps onto a rim of a bowl. When an annular seat is lowered, it depresses a button which pivots the rod from the center of the bowl towards its side. When the annular seat is raised, the button is released and the rod rotates so as to bring the target towards the center of the bowl. | 2011-12-29 |
20110318721 | Musical System for Young Children - A musical early-learning system in particular for young children, the system comprising a shelter or wall ( | 2011-12-29 |
20110318722 | METHOD AND SYSTEM FOR CAREER INTEGRATED ONLINE LEARNING - An online system enrolls students and manpower resources and connects to a suitable careers based on their back-ground, skills and choices and provides appropriate learning with appropriate assessments to connect/map suitable careers to the student while learning. Allows clients to provide requirements along with related position specifications to compare, check, and engage resources for a position. Provides automated learning content with metrics including interactive automated assessments to train resources to make them ready for the particular job and engaged, should there be a requirement to undergo training as part of the requirement. Education centers having multimedia based PCs are connected to a centralized system having a database and application that connects a student, requirements, and client to impart learning before the resource is allocated to the position. Secured network is deployed with a centralized software to seamlessly deliver training, job engagement and allocation, fee based registration and enrollment, and assessments. | 2011-12-29 |
20110318723 | Studying system and method with virtual cards - The studying system and studying method using virtual card are described. The present invention comprises: (1) a course scheduling feature that divides study courses into a plurality of study sessions considering the learning situations of the user, selects and assigns virtual flash cards to such study sessions, and determines the sequence of such virtual flash cards contained in such study sessions; (2) a session management feature that carries out such study sessions by displaying the front side of the virtual flash cards contained in such study sessions and by allowing the users to enter answers to such virtual flash cards; and (3) an entry management feature that provides an interface for users to enter such answers. The present invention provides a distinct studying method by dividing a study course into a plurality of study sessions, assigning virtual flash card decks to appropriate such study sessions and determining the order of such virtual flash cards, displaying the front side of such virtual flash cards to the user, and allowing the user to enter the answer for each virtual flash card. The invention maximizes learning the benefits of users by providing and displaying virtual flash cards in the order that best suits the users' situations. | 2011-12-29 |
20110318724 | EQUATION-BASED ASSESSMENT GRADING METHOD AND PARTICIPANT RESPONSE SYSTEM EMPLOYING SAME - A computerized assessment grading method comprises creating a syntax tree for a received equation-based response to at least one assessment question and a syntax tree for at least one solution to the at least one question, comparing the syntax trees, and grading the response based on the results of the comparison. | 2011-12-29 |
20110318725 | CELL CULTURE METHOD, CELL CULTURE DEVICE, METHOD FOR COUNTING SUBSJECT MATTERS TO BE COUNTED IN CONTAINER AND DEVICE FOR COUNTING - Cell aggregate formation control and cell aggregate disintegration control are carried out with respect to cells in a culture container to increase cell proliferation efficiency. The number of the cells in the culture container is counted without disassembly of a culture system and irrespective of the density of the cells. | 2011-12-29 |
20110318726 | PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS - Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease. | 2011-12-29 |
20110318727 | GENETIC MARKER FOR DETECTION OF HUMAN PAPILLOMAVIRUS - The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV identify individuals at risk of developing or in the early stages of cervical carcinoma. | 2011-12-29 |
20110318728 | SYSTEMS, DEVICES, METHODS AND KITS FOR FLUID HANDLING - Fluid handling devices, systems, methods and kits are disclosed. Fluid handling devices according to the disclosure comprise: an inlet for receiving a sample; a reagent layer comprising, a substrate having a first surface and an opposing second surface, at least one reagent storage compartment configured to hold a reagent, and a seal in communication with the at least one reagent storage compartment; and a reaction layer having a first surface and an opposing second surface comprising, a reaction area, and an outlet in communication with the reaction area, wherein the reagent layer and reaction layer are adapted and configured to permit movement of at least one of the reagent layer and the reaction layer in a plane relative to the other layer. | 2011-12-29 |
20110318729 | Rapid Bioluminescence Detection Assay - An assay is provided for detecting the activity of a reporter kinase comprising (i) adding said reporter kinase to an assay mixture wherein said reporter kinase is contacted with bioluminescent reagent no more than minutes after being contacted with ADP, and wherein, prior to contacting the reporter kinase with ADP, the assay mixture is substantially free from kinase other than reporter kinase; and (ii) detecting light output from the assay mixture. Methods for detecting the presence of an analyte in a sample and methods for validating a treatment process using the above assay are also provided. Further provided are devices for conducting these assays and methods. | 2011-12-29 |
20110318730 | MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS - Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and include a reporter of virus or parasite infection. Methods of making and using the cell cultures are also provided. | 2011-12-29 |
20110318731 | QUANTITATIVE HELICASE ASSAY - Disclosed herein are methods and kits relating to detection and quantitation of helicase activity. | 2011-12-29 |
20110318732 | PREDICTION OF CHEMOTHERAPEUTIC RESPONSE VIA SINGLE-CELL PROFILING OF TRANSCRIPTION SITE ACTIVATION - The present invention generally relates to methods for determining tumor resistance or sensitivity to chemotherapeutic agents and the likelihood of tumor reoccurrence based on the expression levels of genes known to correlate to the chemotherapeutic agent. In particular, the expression levels of TYMS, MRGX, ATP7B and/or BAK in tumor cells, as measured by the number of active transcription sites detected by fluorescence in situ hybridization (FISH), are predictive of resistance and sensitivity to chemotherapy and the likelihood of reoccurrence following chemotherapy treatment. | 2011-12-29 |
20110318733 | TEST SYSTEM AND METHOD FOR THE DETECTION OF ANALYTES - The invention relates to analytical test systems and analytical methods, in which molecular switches are used for the qualitative and quantitative determination of analytes in a sample, which have a broad application by means of a selection of the molecular switch suitable for the analyte. The molecular switch comprises a probe, preferably a nucleic acid or a nucleic acid derivative, coupled to a catalytic component, preferably an enzyme. The analyse induces a conformation change in the probe, which alters the accessibility for a substrate in the probe to catalytic components and the change in substrate turnover, corresponding to the change in catalytic activity, is measured. | 2011-12-29 |
20110318734 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 2011-12-29 |
20110318735 | REGULATION OF THE SEROTONIN REUPTAKE TRANSPORTER AND DISEASE - Described herein is a CpG island in the 5′ region of the 5HTT gene that contains an alternative exon 1 and promoter for 5HTT. Methylation at this CpG island is associated with decreased levels of 5HTT mRNA, and this effect is evident when 5HTTLPR genotype is taken into account. Thus, this methylation status indicates 5HTT mRNA production, which serves as an indicator for the expression of the transporter and of a subject's vulnerability to diseases related to serotonergic activity. Accordingly, certain embodiments of the present invention provide diagnostic methods for determining whether a subject has, or is at risk for developing, a disease associated with serotonergic activity. | 2011-12-29 |
20110318736 | Allele Amplification Bias - Methods are provided for nucleic acid analysis. In an illustrative method, allele amplification bias is used to amplify preferentially a target nucleic acid that is present in a low allele fraction. | 2011-12-29 |
20110318737 | REAL-TIME POLYMERASE CHAIN REACTION DETECTION OF LEGIONELLA PNEUMOPHILA AND DIFFERENTIATION FROM OTHER LEGIONELLA SPECIES - Materials and processes are provided for the detection of | 2011-12-29 |
20110318738 | IDENTIFICATION AND REGULATION OF A NOVEL DNA DEMETHYLASE SYSTEM - Disclosed herein are methods and systems directed at detecting, evaluating, ameliorating, preventing and treating an oncogenic event. The disclosed methods and systems can comprise one or more Demethylase System Components or other compositions that can be used alone or in combination to detect, evaluate, treat, ameliorate, or prevent an oncogenic event. | 2011-12-29 |
20110318739 | DETERMINATION OF THE DEGREE OF DNA METHYLATION - The present invention provides oligonucleotides and processes for determining the normalized methylation level of DNA, and for determining the relative methylation level of DNA between at least two samples. The invention makes use of the random distribution of transposons in the genome. The disclosed oligonucleotides and processes are of importance, in particular, for clinical diagnostics. | 2011-12-29 |
20110318740 | Reduced Interference from Single Strand Binding Proteins - Disclosed, for example, are methods for detecting at least one target polynucleotide comprising cleaving a flap from a polynucleotide probe that is hybridized to a complementary target polynucleotide, and hybridizing the cleaved flap to a complementary capture probe immobilized on a surface, wherein said cleaving and/or hybridizing occurs in the presence of a single strand binding protein that is capable of binding single-stranded DNA, but that can bind neither the flap nor the capture probe. The cleaved flap and the complementary capture probe may each comprise PNA, RNA, LNA, L-DNA or other modified nucleotides or chimeras thereof that do not significantly bind to the single strand binding protein. | 2011-12-29 |
20110318741 | BIOMARKERS FOR THE TREATMENT OF PSORIASIS - Provided herein are the biomarkers for predicting or monitoring the efficacy of a treatment for psoriasis. The use of certain cell markers and mRNA levels as biomarkers to predict whether a psoriasis treatment is likely to be successful is also provided. Further, the expression of these genes or cell markers can be used to monitor progress of treatment effectiveness and patient compliance in psoriasis patients who are receiving treatment. | 2011-12-29 |
20110318742 | MICRO RNA MARKERS FOR COLORECTAL CANCER - There are disclosed methods for diagnosing or providing a prognosis for colorectal cancer cells in a biological sample, the method comprising the steps of detecting the presence in the biological sample of an RNA sequence at least about 98% similar over the full sequence length to a sequence selected from the group consisting of SEQ ID NOS:1-7, wherein the presence of the RNA sequence is indicative of the presence of colorectal cancer cells in the sample. Probes for detecting and providing a prognosis for colorectal cancer are also disclosed. | 2011-12-29 |
20110318743 | METHODS, WORKFLOWS, KITS, APPARATUSES, AND COMPUTER PROGRAM MEDIA FOR NUCLEIC ACID SAMPLE PREPARATION FOR NUCLEIC ACID SEQUENCING - A method for preparing a nucleic acid sample for nucleic acid sequencing includes amplifying a nucleic acid target sequence using a primer bound to a first capture substrate; capturing an amplified nucleic acid product by the first capture substrate; generating at least one sequencing ladder from the amplified nucleic acid product using at least one sequencing primer; capturing the at least one sequencing ladder by hybridizing the at least one sequencing ladder to a complementary capture compound on a second capture substrate; and removing the at least one sequencing ladder from the second capture substrate. The first and/or second capture substrate may include a magnetic particle. Other methods, workflows, kits, and computer program media for nucleic acid sample preparation are also disclosed. | 2011-12-29 |
20110318744 | Method For The Detection And Characterization Of Microorganisms On A Filter - The present invention relates to a method for the specific detection on a filter of one or more microorganisms present in a fluid, characterized in that it comprises the following steps:
| 2011-12-29 |
20110318745 | COMPOSITIONS AND METHODS FOR PERFORMING HYBRIDIZATIONS WITH SEPARATE DENATURATION OF THE SAMPLE AND PROBE - The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences. | 2011-12-29 |
20110318746 | RAPID OLIGO PROBES - Disclosed are methods, rapid probes, and kits for general purpose nucleic acid detection. | 2011-12-29 |
20110318747 | Nonseparation Assay Methods - Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent compound and is conjugated to a specific binding pair member is added in excess along with the sample to the solid support. Addition of a trigger solution causes a chemiluminescent reaction at the sites where the activator conjugate has been specifically bound. The assay methods are termed non-separation assays because they do not require removal or separation of excess detection label (activator conjugate) prior to the detection step. The methods are applicable to various types of assays including immunoassays, receptor-ligand assays and nucleic acid hybridization assays. | 2011-12-29 |
20110318748 | Modified Proteins and Methods of Making and Using Same - Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions. | 2011-12-29 |
20110318749 | METHOD FOR IDENTIFYING REGULATORY T CELLS - The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells. | 2011-12-29 |
20110318750 | METHODS FOR DETECTING AND QUANTIFYING VIABLE BACTERIAL ENDO-SPORES - Methods and systems for detecting viable bacterial endospores in a sample and related methods to quantify viable bacterial endospores in a sample. | 2011-12-29 |
20110318751 | PUMA, A PRO-APOPTOTIC GENE, AS A NOVEL MOLECULAR BIOMARKER FOR TNFalpha-INDUCED HUMAN ISLET DAMAGE - p53-upregulated modulator of apoptosis (PUMA) is a biomarker associated with islet cell health. If PUMA is low, islet cells are typically healthy. If PUMA is high, islet cells are typically unhealthy or dying. PUMA may be measured by either measuring its nucleic or amino acid. PUMA mRNA may be induced by TNF-α stimulation in a time- and dose-dependent manner and β cell apoptosis is induced through a mitochondrial pathway. TNF-α significantly inhibited glucose-induced preproinsulin precursor mRNA synthesis. Such β cell stress signaling in human islets indicates overall state of islet health and, ultimately, the risk of onset and/or degree of severity of both type 1 and type 2 diabetes mellitus. | 2011-12-29 |
20110318752 | METHOD FOR IMPROVING THE YEILD OF A POLYPEPTIDE - The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host. | 2011-12-29 |
20110318753 | NEW COMPOUND, PHOSPHORYLATION INHIBITOR, INSULIN RESISTANCE IMPROVING AGENT, PREVENTIVE OR THERAPEUTIC AGENT FOR DIABETES, AND SCREENING METHOD - A new compound inhibiting phosphorylation of Ser727 of STAT3, a phosphorylation inhibitor containing the new compound, an insulin resistance improving agent and a preventive or therapeutic agent for diabetes; and a screening method for at least one of the insulin resistance improving agent and the preventive or therapeutic agent for diabetes. | 2011-12-29 |
20110318754 | Reduction in False Results in Assay Measurements - Methods and reagents are disclosed for detecting a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises measuring assay signal resulting from background only and measuring assay signal resulting from the presence of analyte in the sample plus background and subtracting the first measurement from the second measurement to determine the concentration of analyte in the sample. For example, a measurement result 1 is determined by means of an assay conducted on a portion of the sample where analyte in the sample is substantially sequestered and a measurement result 2 is determined by means of the assay conducted on an equal portion of the same sample where analyte in the sample is substantially non-sequestered. Measurement result 1 is subtracted from measurement result 2 to determine the concentration of analyte in the sample. | 2011-12-29 |
20110318755 | Universal Testing Platform for Medical Diagnostics - The invention relates to analysis of samples (for example, blood, urine, saliva, or swab). Some embodiments include a diagnostic testing platform. The platform may permit the analysis of a plurality of different samples with no or only minor modifications made to the platform. This platform may also reduce the number of steps performed by a user, and offer increased sensitivity and precision. The platform may be integrated with a low-cost instrument and provide an accurate digital analysis of the reaction. | 2011-12-29 |
20110318756 | SMALL SPECIMEN STAINING AND DIAGNOSING OF CELLS - An immunohistochemical staining of small specimen comprises using a plurality of antibodies and/or antigens to mark certain cells with particular colors of stains in order to distinguish target cells, such as carcinoma cells, in a stained small specimen. For example, antibodies CD44, cytokeratin 20 and p53 may be used for selectively staining a specimen of a urothelial mucosal biopsy on a single slide. Mouse monoclonal antibody CD44 is associated only with reactive urothelial cells, while rabbit monoclonal antibody p53 is associated only with carcinoma cells. Mouse monoclonal antibody cytokeratin 20 is associated with both “umbrella cells” and carcinoma cells, but antibody p53 is not associated with umbrella cells, which are the most superficial urothelial cells and are characterized morphologically from the other cells in a prepared specimen. Thus, diagnosis is facilitated by the staining of carcinoma cells in a contrasting color to normal urothelial cells and superficial urothelial cells. | 2011-12-29 |
20110318757 | RECOMBINANT ANTI-MUC1 ANTIBODIES - Antibodies having a high specificity and high affinity towards the human gene product MUC1, which in specific variants is associated with neoplastic cells, i.e. tumor tissue, to the use of the antibodies for medical purposes, i.e. for tumor treatment, and for analytical purposes, e.g. for tumor diagnosis. Compositions comprising the antibodies, e.g. for use in the analytical processes and analyses, to pharmaceutical compositions comprising the antibodies, and to use of the antibodies in the manufacture of pharmaceutical compositions for tumor treatment or for diagnostic purposes. | 2011-12-29 |
20110318758 | HUMAN MONOCLONAL ANTIBODIES AND METHODS FOR PRODUCING THE SAME - The present invention provides for methods of producing human monoclonal antibodies against a wide variety of antigens including bacterial and viral antigens, as well as tumor antigens, and various autoantigens. Also provided are the antibodies themselves, nucleic acids encoding such antibodies, cells producing such antibodies, and methods of using such antibodies for diagnostic assays and passive immunity against disease states such as infection and cancer. | 2011-12-29 |
20110318759 | METHOD FOR ASSAYING KERATAN SULFATE, ASSAY KIT THEREFOR AND METHOD FOR DETECTING JOINT DISEASE BY USING THE SAME - The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50 | 2011-12-29 |
20110318760 | METHOD FOR THE IN VITRO DIAGNOSIS OF AN AUTOIMMUNE RESPONSE ASSOCIATED WITH THE EXISTENCE OF AN ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES-ASSOCIATED VASCULITIS BY DETECTION OF ANTIBODIES DIRECTED AGAINST THE PENTRAXIN 3 ANTIGEN - A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and kits for implementing the method. | 2011-12-29 |
20110318761 | METHODS AND KITS FOR PREDICTING A RESPONSE TO AN ERYTHROPOIETIC AGENT - Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17. | 2011-12-29 |
20110318762 | Graft-Versus-Host Disease Predicting Marker and Use Thereof - A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody. | 2011-12-29 |
20110318763 | DETECTION OF CANCER BY ELEVATED LEVELS OF BCL-2 - The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that detects or binds to Bcl-2 protein or an agent that detects or binds to encoding nucleic acids, such as antibodies specifically reactive with Bcl-2 protein or a portion thereof. The invention further relates to kits for carrying out the methods of the invention. The invention further relates to a device for the rapid detection of Bcl-2 in a bodily fluid and methods for rapidly measuring Bcl-2 in a bodily fluid. | 2011-12-29 |
20110318764 | METHOD FOR DETECTING MUSCLE DEGENERATIVE DISEASES, AND METHOD FOR DETERMINING THERAPEUTIC EFFICACY ON THE DISEASES - Muscle degenerative diseases can be detected in the early stage and the therapeutic efficacy of a therapeutic agent and/or a therapy method for the diseases can be determined by measuring 11,15-dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (referred to as “Tetranor-PGDM”, hereinbelow) in a sample isolated from a subject. | 2011-12-29 |
20110318765 | METHOD FOR PRE-TREATING SAMPLE CONTAINING GLYCATED HEMOGLOBIN - There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time; and an method for an immunological assay of glycated hemoglobin using this technique. | 2011-12-29 |
20110318766 | Arginine vasopressin pro-hormone as predictive biomarker for diabetes - Subject of the present invention are assays and in vitro methods for the prediction of the risk of a subject for contracting metabolic syndrome and/or diabetes mellitus and for diagnosing metabolic syndrome, comprising determining the level of arginine vasopressin pro-hormone or fragments thereof in a sample of a subject. | 2011-12-29 |
20110318767 | Method for Measuring Plasma Glucose - A measurement of plasma glucose is carried out through the following steps, a sample preparation step (S | 2011-12-29 |
20110318768 | METHOD FOR DETERMINING SENSITIVITY OF TUMOR CELLS TO TYROSINE KINASE INHIBITOR AND COMPUTER PROGRAM PRODUCT - The present invention provides a method for determining sensitivity of the tumor cells to an EGFR and/or HER | 2011-12-29 |
20110318769 | METHOD AND COMPOSITION FOR TARGETING VICIOUS CYCLES OF STRESSES AND INFLAMMATORY RESPONSES - The present invention provides methods and compositions for targeting the pathologically relevant bipolar actions of these master integrators without affecting the basal physiologically relevant functions. NFA can be used as marker of vicious cycles. Partial inhibition of NFA will be less toxic (in most cases) and more efficient for simultaneous partial inhibitions of all key mediators to terminate this vicious cycles for prevention and treatment of the long-term stresses and chronic inflammation-related diseases without causing any side effects and complications. Aberrant expression of NFA, master stress, and inflammation integrators play a role in orchestrating of vicious cycles. Aspects of the invention provide core technology for simultaneously targeting 12 hallmarks of cancer. | 2011-12-29 |
20110318770 | COMPOSITIONS, KITS AND METHODS FOR DETERMINING PLASMIN ACTIVITY - Compositions, kits, and methods for determining plasmin activity using a fluorogenic peptide substrate are provided. | 2011-12-29 |
20110318771 | DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS - Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more | 2011-12-29 |
20110318772 | REACTIVE COUMARIN DERIVATIVES AND THEIR USE IN CELLULAR ANALYSES - Chemically reactive 7-hydroxycoumarin derivatives and their application for analyzing cell function, for example in combination with additional fluorescent labels. The coumarin derivatives exhibit a strong absorption at 405 nm and high fluorescence quantum yields. | 2011-12-29 |
20110318773 | METHOD TO USE EKTACYTOMETRY TO IMPROVE STORED RED BLOOD CELL OR WHOLE BLOOD PRODUCT UTILIZATION - A method for assessing the quality degradation of an RBC or whole blood unit, the method comprising: 1) using an ektacytometer to generate erythrocyte deformability data for the RBC or whole blood unit; 2) analyzing the erythrocyte deformability data to assess the quality degradation of the RBC or whole blood unit; 3) providing the erythrocyte deformability data to medical personnel; 4) correlating the erythrocyte deformability data with a clinical outcome of a patient that has used the RBC or whole blood unit; and 5) incorporating the erythrocyte deformability data into subsequent assessments of quality degradation of RBC and whole blood units. This method would provide clinicians with actual data on RBC quality when making decisions about which and how many units to use for transfusion of a given patient. Moreover, deploying the approach throughout the supply chain will improve distribution, planning, and inventory control decisions. | 2011-12-29 |
20110318774 | DUAL SAMPLE CARTRIDGE AND METHOD FOR CHARACTERIZING PARTICLES IN LIQUID - The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device for sampling a small and accurate volume of liquid. The apparatus comprises a housing having a mixing chamber and a collection chamber separated by a wall containing an opening, a first bore in the outer surface of the housing for entrance of a liquid sample, a first cavity for receiving and holding a first liquid sample, and a second cavity for receiving and holding a second liquid sample. | 2011-12-29 |
20110318775 | METHOD, SYSTEM AND COMPOSITION FOR OPTICALLY INDUCING CARDIOMYOCYTE CONTRACTION - The present invention provides a method, system and composition for screening drug candidates for cardiotoxicity and for novel drugs that effect cardiomyocyte contractility and function. The invention provides an efficient and reliable screening assay to detect the effect of new and potential drug candidates on cardiomyocyte calcium flux, membrane depolarization, and/or the propagation of action potentials. | 2011-12-29 |
20110318776 | Method for identifying germs in a liquid medium - This invention relates to a method for identifying germs in a liquid medium, comprising adding a membrane detergent to the liquid medium containing components of a host infected with germs, i.e. cellular components and proteins from the extracellular environment, so as to release the germs from these components without degrading them, and in that the germs that have grown in the liquid medium are analysed by MALDI-TOF MS. | 2011-12-29 |
20110318777 | DEVICE FOR METERING CELLS, METHOD FOR METERING CELLS AND ALSO USE OF THE DEVICE - The invention relates to a device for metering cells and also to a method for metering cells. Furthermore, the invention relates to the use of the device for metering cells. | 2011-12-29 |
20110318778 | Organic Substrate Treatment System - The present invention is directed to an organic substrate treatment system that converts organic substrate and other organic materials to nutrient rich effluent and biogas. Using sequential degradation of the organic materials, biogas and effluent is efficiently produced with relatively short digestion times. Additives are added to the organic materials prior to anaerobic digestion to enhance biogas production. A desulfurizer may be used to clean the raw biogas so that it is suitable for use with gas engines and boilers. | 2011-12-29 |
20110318779 | PROCESS FOR PRODUCING RECOMBINANT PROTEIN USING NOVEL FUSION PARTNER - The present invention provides a method of producing polypeptide utilizing a fusion protein of A-B type in the following formula (I), by culturing transformed microorganism comprising DNA sequence encoding the desirable polypeptide; A-B (I). In the above formula (I), A is a fusion partner of 25 or more amino acid residues where aspartic and glutamic acid residues are incorporated to have a net negative charge of 30% or more, and B is the target protein to be produced. The target protein can be isolated from the fusion protein by employing enzymatic cleavage site etc. at the carboxyl-terminus of the fusion partner. | 2011-12-29 |
20110318780 | ENZYMATIC MODIFICATION OF GLYCOPEPTIDES - The present invention provides glycoconjugates that are formed through the enzymatically-mediated coupling of a glycosyl moiety, e.g., on a peptide or lipid, and a modifying group that includes an acyl group. The conjugates include the modifying group tethered to the glycosyl moiety through a linking moiety that includes an acyl residue. Also provided are methods for preparing the conjugates of the invention | 2011-12-29 |
20110318781 | CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(Tyr-Xaa) CYCLODIPEPTIDES - Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof. | 2011-12-29 |