51st week of 2011 patent applcation highlights part 49 |
Patent application number | Title | Published |
20110312800 | TEST MODULE FOR GRAVITY-INDEPENDENT OPERATION - A test module for analyzing genetic material in a biological sample, the test module having an outer casing with a receptacle for receiving the biological sample, functional sections for processing and analyzing the biological sample, a controller for operating the functional sections, and, a flow-path from the receptacle to the functional sections, wherein, the flow-path is configured to draw the sample to be analyzed from the receptacle to the functional sections by capillary action regardless of module orientation relative to gravity. | 2011-12-22 |
20110312801 | TEST MODULE WITH LANTHANIDE METAL-LIGAND COMPLEX FLUOROPHORE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the fluorophore is a lanthanide metal-ligand complex. | 2011-12-22 |
20110312802 | TEST MODULE WITH PROBES SUSPENDED IN FLUID - A test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target nucleic acid sequence to form probe-target hybrids, the probes each having a fluorophore such that the probe-target hybrids emit a fluorescence signal in response to exposure to an excitation light, wherein, the probes are suspended in a fluid. | 2011-12-22 |
20110312803 | SYSTEM FOR VARIABLE LOADING OF REAGENTS INTO MICROFLUIDIC DEVICE FOR GENETIC ANALYSIS - A system for loading reagents into a microfluidic device for genetic analysis, the system having containers with reagents for processing a biological sample in the microfluidic device, an integrated circuit secured to each of the containers respectively, each of the integrated circuits having a container digital memory storing reagent specification data related to the reagent in that container, a microfluidic device for performing a desired genetic test assay, the microfluidic device having a device digital memory, a reagent dispensing apparatus for loading a selection of the reagents into the microfluidic device, the reagent dispensing apparatus having a control microprocessor for accessing the container digital memory and transmitting the specification data to the device digital memory, and, a device reader for accessing the reagent specification data from the device digital memory in order to analyze test assay results from the microfluidic device. | 2011-12-22 |
20110312804 | MICROFLUIDIC DEVICE WITH APERTURE WITH GEOMETRY TO PROMOTE UNPINNED FLOW-THROUGH OF FLUID - A microfluidic device having a channel having an inlet, an outlet and an aperture between the inlet and the outlet, wherein, the aperture has a geometry that does not allow a meniscus of the fluid flow to anchor to the aperture, such that fluid flow from the inlet towards the outlet is uninterrupted. | 2011-12-22 |
20110312805 | TEST MODULE WITH TIME DELAYED DETECTION OF FLUORESCENCE FROM HYBRIDIZED PROBE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, control circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the control circuitry is configured to initiate a time delay upon deactivation of the excitation light before activating the photosensor. | 2011-12-22 |
20110312806 | MICROFLUIDIC DEVICE WITH HUMIDIFIER - A microfluidic device for analyzing a fluid sample containing target molecules, the microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for processing the fluid sample, the MST layer having an array of probes configured to combine with the target molecules to form probe-target complexes, and, a humidifier configured to heat water for localized humidification of an area encompassing the MST layer. | 2011-12-22 |
20110312807 | MICROFLUIDIC TEST MODULE WITH A MEMBRANE SEAL TO PREVENT DEHUMIDIFICATION OF THE MIXTURE - A microfluidic test module for analyzing genetic material, the test module having a casing configured for hand-held portability, an array of probes housed in the casing, the probes being configured to hybridize with target nucleic acid sequences to form probe-target hybrids, wherein, the casing has a membrane seal for reducing dehumidification within the casing and providing pressure relief from small air pressure fluctuations. | 2011-12-22 |
20110312808 | TEST MODULE WITH CONTROLLED EXPOSURE OF FLUOROPHORES TO EXCITATION LIGHT SOURCE - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, control circuitry having a photosensor for generating an output signal in response to the fluorescence signal, wherein, the control circuitry is configured to initiate a time delay upon deactivation of the excitation light before activating the photosensor. | 2011-12-22 |
20110312809 | TEST MODULE WITH HUMIDIFIER - A test module for analyzing genetic material, the test module having a casing configured for hand-held portability, an array of probes housed in the casing, the probes being configured to hybridize with target nucleic acid sequences to form probe-target hybrids, and, a humidifier for increasing the humidity within the casing. | 2011-12-22 |
20110312810 | SINGLE-USE TEST MODULE FOR DETECTION OF HYBRIDIZATION OF TARGETS WITH OLIGONUCLEOTIDE PROBES - A single-use test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, a photosensor to detect the fluorescence signal. | 2011-12-22 |
20110312811 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH ELECTRODES PROFILED FOR GREATER PERIPHERAL EDGE LENGTH - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes are plates of conductive material, the plates having edge profiles configured such that the length of peripheral edge of each of the plates is greater than 128 microns. | 2011-12-22 |
20110312812 | GENETIC TEST MODULE WITH FEEDBACK-CONTROLLED HUMIDIFIER - A test module for processing genetic material in a biological sample, the test module having a casing, a microfluidic device housed in the casing, the microfluidic device having reagents for processing the genetic material, a humidifier for increasing the humidity within the casing, a humidity sensor for sensing the humidity within the casing, wherein, the humidity sensor generates an output used for control of the humidifier. | 2011-12-22 |
20110312813 | SINGLE-USE GENETIC TEST MODULE - A single-use test module for detecting hybridization of probes with nucleic acid sequences, the test module having a sample input for receiving a biological sample with target nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences in the biological sample, an array of probes for hybridization with target nucleic acid sequences in the biological sample, and, circuitry having a photosensor for sensing hybridization between the probes and target nucleic acid sequences in the biological sample, wherein, the circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized. | 2011-12-22 |
20110312814 | SINGLE-USE TEST MODULE WITH EXCITATION SOURCE - A single-use test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, an excitation light source. | 2011-12-22 |
20110312815 | MICROFLUIDIC DEVICE WITH HUMIDITY SENSOR - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for processing a fluid sample, and, a humidity sensor for sensing the humidity of an area encompassing the MST layer, wherein, the humidity sensor generates an output for humidity control of the area encompassing the MST layer. | 2011-12-22 |
20110312816 | TEST MODULE WITH LED FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, and, an excitation LED for generating the excitation light, the LED positioned in the outer casing for simultaneously illuminating all the probes. | 2011-12-22 |
20110312817 | MICROFLUIDIC TEST MODULE WITH HUMIDITY SENSOR - A test module for analyzing a sample containing nucleic acid sequences, the test module having a casing configured for hand-held portability, an array of probes housed in the casing, the probes being configured to hybridize with target nucleic acid sequences in the sample to form probe-target hybrids, a humidity sensor for sensing the humidity within the casing, wherein, the humidity sensor generates an output for humidity control within the casing. | 2011-12-22 |
20110312818 | TEST MODULE WITH EXCITATION LIGHT AND LENS FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, a lens positioned in the outer casing for directing light from the excitation light to simultaneously illuminate the probes. | 2011-12-22 |
20110312819 | LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENCE OF A LUMINOPHORE IN THE PRESENCE OF AN ELECTROCHEMICAL COREACTANT - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, an electrochemical coreactant that is present with the luminophore during electrochemiluminescence. | 2011-12-22 |
20110312820 | TEST MODULE WITH EXCITATION LIGHT AND PRISMS FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, prisms positioned in the outer casing for redirecting light from the excitation light to simultaneously illuminate the probes. | 2011-12-22 |
20110312821 | MICROFLUIDIC DEVICE WITH WASTE STORAGE - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for analyzing a fluid, and, a waste reservoir for storage of waste material separated from the fluid. | 2011-12-22 |
20110312822 | GENETIC ANALYSIS LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes. | 2011-12-22 |
20110312823 | TEST MODULE WITH EXCITATION LIGHT AND MIRRORS FOR SIMULTANEOUS EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid, the probe-target hybrid being configured to generate a fluorescence signal in response to an excitation light, an excitation light for generating the excitation light, and, mirrors positioned in the outer casing for redirecting light from the excitation light to simultaneously illuminate the probes. | 2011-12-22 |
20110312824 | TEST MODULE WITH WASTE STORAGE INCORPORATING POROUS ELEMENT - A test module for analyzing fluid containing target nucleic acid sequences, the test module having a casing for hand-held portability, the casing having a receptacle for receiving the fluid, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, and, a waste accumulator for storage of waste material separated from the fluid, wherein, the waste accumulator has a waste reservoir and a porous element to draw the waste material into the waste reservoir by capillary action. | 2011-12-22 |
20110312825 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION WITH ELECTRODE PAIRS HAVING COMPLEMENTARY AND MUTUALLY INTERDIGITATED FINGER FORMATIONS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes have an anode and a cathode, each having fingers configured for mutual interdigitation. | 2011-12-22 |
20110312826 | TEST MODULE WITH LASER FOR EXCITATION OF OLIGONUCLEOUTIDE PROBES - A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in the outer casing for hybridization with a target nucleic acid sequence to form probe-target hybrids, the probe-target hybrids being configured to generate a fluorescence signal in response to an excitation light, a laser positioned in the outer casing for generating the excitation light. | 2011-12-22 |
20110312827 | GENETIC ANALYSIS LOC DEVICE FOR DETECTION OF TARGET SEQUENCES WITH ELECTROCHEMILUMINESCENT LUMINOPHORE AND FUNCTIONAL MOIETY FOR QUENCHING PHOTON EMISSIONS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, an electrochemiluminescent (ECL) luminophore, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes. | 2011-12-22 |
20110312828 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING ELECTRODE PAIRS OPTICALLY COUPLED TO PHOTODIODE - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrode pairs in which one electrode in each of the electrode pairs is a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, and, photodiodes corresponding to each of the electrode pairs respectively, wherein, the photodiodes have a planar active surface area for receiving the light from the luminophore, and the working electrode has a surface area optically coupled to the active surface area of the photodiode, the working electrode being configured such that the optically coupled surface area is greater than 50% of the active surface area of the photodiode. | 2011-12-22 |
20110312829 | LOC DEVICE FOR GENETIC ANALYSIS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light. | 2011-12-22 |
20110312830 | GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES HAVING A FUNCTIONAL MOIETY FOR QUENCHING PHOTON EMISSIONS CONFIGURED TO CHANGE PROXIMITY TO A LUMINOPHORE UPON FORMING A PROBE-TARGET HYBRID - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, an electrochemiluminescent (ECL) luminophore, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein during use, the functional moiety changes proximity to the luminophore upon formation of a probe-target hybrid. | 2011-12-22 |
20110312831 | LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCE WITH ELECTROCHEMILUMINESCENT METALORGANIC COMPLEX - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) metalorganic complex, and, electrodes for generating an excited state in the metalorganic complex in which the metalorganic complex emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes. | 2011-12-22 |
20110312832 | LOC DEVICE FOR DETECTION OF TARGET SEQUENCES WITH ELECTROCHEMILUMINESCENT PROBES IN HYBRIDIZATION CHAMBERS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, an array of hybridization chambers, each of the hybridization chambers having a pair of the electrodes respectively and containing a plurality of the probes, the nucleic acid sequence in the probes in each of the hybridization chambers being different to the nucleic acid sequence in at least one other hybridization chamber in the array such that a plurality of target nucleic acid sequences are detectable. | 2011-12-22 |
20110312833 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES USING TRANSPARENT ELECTRODES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes are arranged in pairs, one of the electrodes in each electrode pair being a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, the working electrode being transparent to light at the wavelength of the photons emitted by the ECL luminophores. | 2011-12-22 |
20110312834 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING A RUTHENIUM ORGANIC COMPLEX - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and a ruthenium organic complex, electrodes for generating an excited state in the ruthenium organic complex in which the ruthenium organic complex emits photons of light, and, CMOS circuitry for applying a voltage across the electrodes. | 2011-12-22 |
20110312835 | GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore. | 2011-12-22 |
20110312836 | MICROFLUIDIC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having reagent reservoirs for adding reagents to the sample prior to detection of the target nucleic acid sequences, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light. | 2011-12-22 |
20110312837 | LOC DEVICE FOR GENETIC ANALYSIS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes are plates of conductive material, the plates having peripheral edges optically coupled to the photosensor. | 2011-12-22 |
20110312838 | MICROFLUIDIC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET MOLECULES - A microfluidic device for detecting target molecules in a fluid, the microfluidic device having reagent reservoirs for adding reagents to the fluid prior to detection of the target molecules, probes for reaction with the target molecules to form probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore. | 2011-12-22 |
20110312839 | GENETIC ANALYSIS LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH WORKING ELECTRODE IN CONTACT WITH PHOTOSENSOR - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes have at least one working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits the photons, the working electrode being positioned immediately adjacent the photosensor. | 2011-12-22 |
20110312840 | MICROFLUIDIC DEVICE WITH SAMPLE INLET, ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET SEQUENCES - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of electrochemiluminescent (ECL) probes for hybridization with target nucleic acid sequences in a fluid, and electrode pairs for receiving an electrical pulse, the ECL probes being configured to emit a photon of light when hybridized with one of the nucleic acid targets and activated by one of the electrodes, and, a photosensor for detecting photons of light from the ECL probes that have hybridized. | 2011-12-22 |
20110312841 | FABRICATION SYSTEM FOR LAB-ON-A-CHIP (LOC) DEVICES WITH DIFFERING APPLICATION SPECIFIC FUNCTIONALITY - A fabrication system for lab-on-a-chip (LOC) devices with differing application specific functionality, the fabrication system having a database of different functional categories, each of the functional categories having a plurality of functional section designs, means for selecting a compilation of the functional section designs to generate a LOC design in accordance with a specific functionality intended for LOC devices fabricated in accordance with the LOC design, and, a MST (microsystems technology) fabrication facility for fabricating LOC devices in accordance with the LOC design, wherein, the functional section designs in any one of the functional categories are functionally compatible with at least one of the functional section designs in the other functional categories. | 2011-12-22 |
20110312842 | OLIGONUCLEOTIDE SPOTTING DEVICE - An oligonucleotide spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, and, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 2011-12-22 |
20110312843 | SPOTTING DEVICE FOR COMPLETE ASSAY SPOTTING OF LOCS - A spotting device for contactless spotting of a lab-on-a-chip (LOC) device with oligonucleotide probes, the LOC device having an array of hybridization chambers for receiving the oligonucleotide probes, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample and the array of hybridization chambers being configured to hold a complete assay of oligonucleotide probes necessary for a predetermined analysis of the biological sample, the spotting device having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, and, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively such that the ejectors eject droplets containing the oligonucleotide probes from the corresponding reservoir into one of the hybridization chambers, wherein, the array of reservoirs is configured to contain the complete assay of oligonucleotide probes necessary for the predetermined analysis to be performed by the LOC device. | 2011-12-22 |
20110312844 | BIOCHEMICAL DEPOSITION DEVICE - A biochemical deposition device for contactless deposition of biochemicals on a surface, the biochemical deposition device having an array of reservoirs for containing a plurality of biochemicals, and, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the biochemical from the corresponding reservoir onto the surface. | 2011-12-22 |
20110312845 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH LAMINAR STRUCTURE - An oligonucleotide spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors overlaying the array of reservoirs, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 2011-12-22 |
20110312846 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH FLUIDICS ON BOTH SIDES OF SUPPORTING SUBSTRATE - An oligonucleotide spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of reservoirs on one side of the supporting substrate, the reservoirs configured for containing the oligonucleotide probes suspended in a liquid, an array of ejectors on the other side of the supporting substrate, and, a plurality of inlet channels for fluid communication between the reservoirs and the ejectors, wherein, the ejectors are configured to eject droplets containing the oligonucleotide probes from the corresponding reservoir onto the surface. | 2011-12-22 |
20110312847 | SPOTTING DEVICE WITH STORED OLIGONUCLEOTIDE SPECIFICATION DATA - A spotting device for contactless spotting of oligonucleotide probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the spotting device having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors in fluid communication with the reservoirs, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, and, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, wherein, the CMOS circuitry has a digital memory. | 2011-12-22 |
20110312848 | OLIGONUCLEOTIDE SPOTTING DEVICE FOR WAFER-SCALE SPOTTING OF LOCS - An oligonucleotide spotting device for contactless spotting of a silicon wafer on which an array of lab-on-a-chip (LOC) devices are fabricated, the LOC devices being configured to use the oligonucleotide probes to detect target nucleic acid sequences in a biological sample and each having an array of hybridization chambers for receiving the oligonucleotide probes, the oligonucleotide spotting device having an array of reservoirs on one side of the supporting substrate, the reservoirs containing sufficient amount of the oligonucleotide probes suspended in a liquid to spot all the LOC devices on the wafer, and, an array of ejectors overlaying the array of reservoirs for fixed movement therewith, such that the ejectors eject droplets containing the oligonucleotide probes from the corresponding reservoir into one of the hybridization chambers. | 2011-12-22 |
20110312849 | OLIGONUCLEOTIDE SPOTTING DEVICE FOR EJECTING LOW VOLUME DROPLETS - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a monolithic supporting substrate, an array of ejectors formed on one side of the supporting substrate such that the ejectors eject droplets containing the oligonucleotide probes onto the surface, wherein during use, each of the ejectors in the array is configured to eject droplets having a volume less than 100 picoliters. | 2011-12-22 |
20110312850 | BIOCHEMICAL DEPOSITION DEVICE WITH HIGH DEPOSITION RATE - A biochemical deposition device for contactless deposition of biochemicals on a surface, the biochemical deposition device having a supporting substrate, an array of reservoirs on one side of the substrate, the reservoirs being configured for containing a plurality of biochemicals, and, an array of ejectors on the other side of the supporting substrate, each of the ejectors being configured for fluid communication with the reservoirs, wherein during use, the array of ejectors eject droplets containing the biochemicals onto the surface at a rate greater than 100 droplets per second. | 2011-12-22 |
20110312851 | DEVICE FOR HIGH DENSITY SPOTTING OF OLIGONUCLEOTIDES - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having an array of ejectors, each having an actuator for ejecting droplets of liquid containing the probes, CMOS circuitry for providing each of the actuators with a drive pulse for droplet ejection, wherein, the array of ejectors is configured to spot the probes onto the surface at a density more than 1 probe spot per square millimeter. | 2011-12-22 |
20110312852 | ROBOTIC SYSTEM FOR LOADING OLIGONUCLEOTIDES INTO SPOTTING DEVICES - A robotic system for spotting oligonucleotides having an oligonucleotide spotting device for contactless spotting of oligonucleotides onto a surface, the oligonucleotide spotting device having an array of ejectors, each having a drop ejection actuator for ejecting droplets of liquid containing the oligonucleotides onto a surface, at least one reservoir in fluid communication with one or more of the ejectors and CMOS drive circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, and, an apparatus for loading oligonucleotides into the oligonucleotide spotting device, the apparatus having a stage for detachably mounting a plurality of the oligonucleotide spotting devices, and a plurality of oligonucleotide containers mounted for movement relative to the stage, each of the oligonucleotide containers having a droplet dispenser for ejecting droplets of fluid containing oligonucleotides into the reservoirs of the oligonucleotide spotting devices. | 2011-12-22 |
20110312853 | OLIGONUCLEOTIDE SPOTTING ROBOT - An oligonucleotide spotting robot for spotting oligonucleotide probes into a microfluidic device having a digital memory for data related to the oligonucleotide probes loaded into the microfluidic device, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the microfluidic device for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the control processor is configured to activate the ejectors, move the ejectors selected for activation into registration with the microfluidic device and download the data to the digital memory. | 2011-12-22 |
20110312854 | OLIGONUCLEOTIDE SPOTTING ROBOT FOR SPOTTING ARRAYS OF LOCS - An oligonucleotide spotting robot for spotting oligonucleotide probes into an array of lab-on-a-chip (LOC) devices, each having a digital memory for data related to the oligonucleotide probes loaded into that LOC device, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the array of LOC devices for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the control processor is configured to activate the ejectors, move the ejectors selected for activation into registration with one or more of the LOC devices and download the data specifically relevant to each of the LOC devices into the digital memory of that LOC device. | 2011-12-22 |
20110312855 | OLIGONUCLEOTIDE SPOTTING ROBOT FOR HIGH DENSITY SPOTTING OF OLIGONUCLEOTIDES - An oligonucleotide spotting robot for spotting oligonucleotide probes onto a substrate, the oligonucleotide dispensing robot having an array of reservoirs for containing the oligonucleotide probes suspended in a liquid, an array of ejectors, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively, a mounting surface for detachably mounting the substrate for movement relative to the ejectors, and, a control processor for operative control of the ejectors and the mounting surface, wherein, the array of ejectors is configured to spot the probes onto the surface at a density more than 1 probe spot per square millimeter. | 2011-12-22 |
20110312856 | APPARATUS FOR DISPENSING REAGENTS, LOADING OLIGONUCLEOTIDE SPOTTING DEVICES AND SPOTTING OLIGONUCLEOTIDE PROBES - An apparatus for dispensing reagents, loading oligonucleotide spotting devices and spotting oligonucleotide probes, the apparatus having a plurality of reagent vials, each with a droplet dispenser, a plurality of oligonucleotide vials, each with a droplet dispenser, a mounting surface for detachably mounting a microfluidic device for movement relative to the reagent vials, and detachably mounting an oligonucleotide spotting device, a chuck for detachably mounting the oligonucleotide spotting device adjacent the mounting surface, and, a control processor for operative control of the reagent and oligonucleotide vials, the oligonucleotide spotting device when mounted in the chuck and movement of the mounting surface relative to the reagent and oligonucleotide vials, and the oligonucleotide spotting device, wherein, the control processor is configured to activate any of the droplet dispensers, move the microfluidic device into registration with the reagent vials and move the oligonucleotide spotting device into registration with the oligonucleotide vials. | 2011-12-22 |
20110312857 | Drilling, Drill-In and Completion Fluids Containing Nanoparticles for Use in Oil and Gas Field Applications and Methods Related Thereto - Drilling, drill-in and completion fluids containing nanoparticles for use in hydrocarbon drilling and recovery processes and methods related thereto are provided. The fluids also include a dual acting shield agent that shields the nanoparticles and also acts as a viscosifier. The fluids can be used in various types of hydrocarbon drilling and recovery processes, such as drilling, drill in, completion, and the like. | 2011-12-22 |
20110312858 | COMPOSITION AND METHODS FOR OILFIELD APPLICATION - The invention provides a method made of steps of providing a composition comprising a first chemical component and a degradable protective layer, wherein the degradable protective layer is at least partially degradable when subject to temperature, pH or time; and introducing into a wellbore the composition and allowing the degradable protective layer to degrade and release the first chemical component. | 2011-12-22 |
20110312859 | PROPPANTS CONTAINING DISPERSED PIEZOELECTRIC OR MAGNETOSTRICTIVE FILLERS OR MIXTURES THEREOF, TO ENABLE PROPPANT TRACKING AND MONITORING IN A DOWNHOLE ENVIRONMENT - In one aspect, the invention relates to a method for “tagging” proppants so that they can be tracked and monitored in a downhole environment, based on the use of composite proppant compositions containing dispersed fillers whose electromagnetic properties change at a detectable level under a mechanical stress such as the closure stress of a fracture. In another aspect, the invention relates to composite proppant compositions containing dispersed fillers whose electromagnetic properties change under a mechanical stress such as the closure stress of a fracture. The currently preferred embodiments use substantially spherical thermoset nanocomposite particles where the matrix comprises a terpolymer of styrene, ethylvinylbenzene and divinylbenzene, a PZT alloy manifesting a strong piezoelectric effect or Terfenol-D manifesting giant magnetostrictive behavior is incorporated to provide the ability to track in a downhole environment, and carbon black particles possessing a length that is less than 0.5 microns in at least one principal axis direction may optionally be incorporated as a nanofiller. | 2011-12-22 |
20110312860 | WEAR-RESISTANT AND LOW-FRICTION COATINGS AND ARTICLES COATED THEREWITH - A composition for a wear-resistant and low-friction coating is presented. The coating composition includes a hard ceramic phase, a metallic binder phase and a lubricant phase. The lubricant phase includes a multi-component oxide. An article having a wear-resistant and low-friction coating and a method of making such a coating are also described. | 2011-12-22 |
20110312861 | Lubricating oil additive and lubricating oil composition containing same - A molybdated succinimide complex is disclosed which is prepared by a process comprising (a) reacting a succinimide of a polyamine of formula I: | 2011-12-22 |
20110312862 | Lubricating oil additive and lubricating oil composition containing same - A molybdated succinimide complex is disclosed which is prepared by a process comprising (a) reacting an alkyl or alkenyl succinimide of a polyamine of formula I | 2011-12-22 |
20110312863 | ORGANIC MOLYBDENUM COMPOUNDS AND LUBRICATING COMPOSITIONS WHICH CONTAIN SAID COMPOUNDS - The present invention provides dicyclopentadienyl molybdenum crosslinked complexes which can be represented by general formula (1) below, the use thereof as friction-modifiers and lubricating compositions which contain these compounds. | 2011-12-22 |
20110312864 | Processes Relating To Alcohols For The Production Of Esters - The present invention relates to alcohols and in particular to C | 2011-12-22 |
20110312865 | SULFOSUCCINATE FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD AND OILY SOIL REMOVAL - A cleaning composition including a sulfosuccinate functionalized alkyl polyglucoside, a water conditioning agent and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food and oily soils. | 2011-12-22 |
20110312866 | ALKYL POLYPENTOSIDES AND ALKYL POLYGLUCOSIDES (C8-C11) USED FOR ENHANCED FOOD SOIL REMOVAL - The invention comprises a hard surface cleaning composition including an environmentally friendly, surfactant derived from renewable bio-based resources. The cleaning composition includes a mixture of alkyl polypentosides and alkyl polyglucosides having primarily between 8 and 11 carbon atoms as a surfactant, an acid source, an optional solvent, a water conditioning agent and water. The hard surface cleaner is preferably substantially free of alkyl phenol ethoxylates and is effective at removing food soils including 20% protein. | 2011-12-22 |
20110312867 | BETAINE FUNCTIONALIZED ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL - A cleaning composition including a betaine functionalized alkyl polyglucoside, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils. | 2011-12-22 |
20110312868 | HAND DISHWASHING DETERGENT - An aqueous cleaning agent for hard surfaces which contains a surfactant combination of fatty alcohol ether sulfate and at least one further surfactant together with 10 to 40 wt. % of a water-soluble salt, may be used for manual dishwashing and is above all suitable for removing stubborn, burnt-on or dried-on soiling while being gentle on the skin. | 2011-12-22 |
20110312869 | CLEANING COMPOSITIONS COMPRISING A MULTI-POLYMER SYSTEM COMPRISING AT LEAST ONE ALKOXYLATED GREASE CLEANING POLYMER - Laundry detergents and cleaning compositions which provide improved cleaning benefits that comprise a novel polymer system. The polymer system comprises one or more amphiphilic alkoxylated grease cleaning polymers, and either a clay soil cleaning polymer; or a soil suspending polymer. | 2011-12-22 |
20110312870 | EMULSION COMPOSITIONS AND A METHOD FOR SELECTING SURFACTANTS - A method for preparing a microemulsion is disclosed which employs a method based upon identification of the phase behavior of a plurality of components comprising the microemulsion. Further disclosed is a microemulsion composition comprising a first component, coupling agent, and surfactant. | 2011-12-22 |
20110312871 | DEVELOPMENT OF AN ALUMINUM HYDROXYDICARBOXYLATE BUILDER - A cleaning composition for removing soils includes an aluminum salt, a hydroxydicarboxylate, an alkalinity source and optionally, a surfactant system. The cleaning composition has a pH of between about 9 and about 14. | 2011-12-22 |
20110312872 | NORRIN IN THE TREATMENT OF DISEASES ASSOCIATED WITH AN INCREASED TGF-BETA ACTIVITY - The present invention relates to Norrin or a functional fragment thereof in the treatment or prevention of diseases associated with an increased TGF-beta activity. In particular, the use of said Norrin or functional fragment thereof to treat fibrotic diseases/disorders or proliferative disorders, like cancers, is part of this invention. | 2011-12-22 |
20110312873 | N-TERMINALLY MODIFIED TETRAPEPTIDE DERIVATIVES HAVING A C-TERMINAL ARGININE MIMETIC - The invention refers to multibasic, N-terminally modified tetrapeptide mimetics with a C-terminal P1-arginine mimetic, methods for their production and use for therapy and prophylaxis of diseases, caused by bacterial pathogens or viruses, as well as for therapy and prophylaxis of diabetes, arteriosclerosis, cancer, Alzheimer's or the onset of obesity, as well as the use of these compounds as inhibitors of the proprotein convertases which cleave behind basic P1 residues, especially for inhibition of the protease furin. | 2011-12-22 |
20110312874 | USE OF A TRPC CHANNEL FOR THE TREATMENT OF A CARDIOVASCULAR DISEASE - The invention refers to the use of a TRPC channel, an inactivating mutant thereof, or a nucleotide sequence coding for the TRPC channel or for the inactivating mutant for the production of a medicament for the treatment of a cardiovascular disease and a method of screening a modulator of the TRPC channel or an inactivating mutant thereof. | 2011-12-22 |
20110312875 | PEPTIDIC COMPOUNDS - The present invention provides a compound of formula I, II, III and IV as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and in the treatment of HIV infection. Also provided are pharmaceutical compositions comprising the compounds of the present invention. | 2011-12-22 |
20110312876 | Method of determining types I, II, III, IV or V or methicillin-resistant staphylococcus aureus (MRSA) in a biological sample - Disclosed are diagnostic methods for determining a subtype of methicillin-resistant | 2011-12-22 |
20110312877 | ENGINEERED TUNABLE NANOPARTICLES FOR DELIVERY OF THERAPEUTICS, DIAGNOSTICS, AND EXPERIMENTAL COMPOUNDS AND RELATED COMPOSITIONS FOR THERAPEUTIC USE - Biomedical nanoparticles are disclosed based on new engineered modular carrier macromolecules, on engineered macromolecules or associated entities providing an internal nanoparticle structure, and compositions for minimizing non-specific binding of the nanoparticles while enabling efficient and convenient targeting to cells and tissues. These nanoparticles may be used to deliver atomic or molecular or associated entities which are useful for diagnostics, primarily in vivo imaging, for therapeutics, for vaccines, or for experimental research. Nanoparticles comprising combinations of active entities such as gene inhibitors with gene expression cassettes or imaging agents with therapeutic agents, and polyamide compounds useful for treatment of microbial infections are also disclosed. | 2011-12-22 |
20110312878 | PHARMACOLOGICALLY ACTIVE PEPTIDE CONJUGATES HAVING A REDUCED TENDENCY TOWARDS ENZYMATIC HYDROLYSIS - The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bound to X. | 2011-12-22 |
20110312879 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY - Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Pro, Gly, a glycolic acid residue or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in non-infected individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These depsipeptides can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 2011-12-22 |
20110312880 | POTENT CHIMERIC NRTI-NNRTI BIFUNCTIONAL INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE - The present invention relates to compounds, in particular, dual antagonists comprising a nucleoside reverse transcriptase inhibitor (NRTI) or a nucleoside competititive reverse transcriptase inhibitor and a non-nucleoside reverse transcriptase inhibitor (NNRTI), linked together using a chemical linker, which may be used to inhibit HIV (HIV-1) reverse transcriptase and in the treatment of HIV infections, more severe cases of HIV infections, including ARC and AIDS, including reducing the likelihood of these infections and disease states. | 2011-12-22 |
20110312881 | BIFUNCTIONAL POLYPEPTIDE COMPOSITIONS AND METHODS FOR TREATMENT OF METABOLIC AND CARDIOVASCULAR DISEASES - The present invention relates to compositions comprising combinations of biologically active proteins linked to extended recombinant polymer, methods of production of the compositions and their use in treatment of metabolic and cardiovascular diseases, disorders and conditions. | 2011-12-22 |
20110312882 | METHODS AND COMPOSITIONS FOR INCREASING THE ANAEROBIC WORKING CAPACITY IN TISSUES - Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine. | 2011-12-22 |
20110312883 | NEURTURIN MOLECULES - Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host cells which express the enhanced neurturin polypeptides. Use of the enhanced neurturin polypeptides, nucleic acids and host cells in the treatment or prevention of disease. | 2011-12-22 |
20110312884 | Noggin-Derived Peptide and Use Thereof - Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics. | 2011-12-22 |
20110312885 | CONTROLLED RELEASE SYSTEM AND MANUFACTURING METHOD THEREOF - A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere. | 2011-12-22 |
20110312886 | TGF- AND METHODS OF TREATING OCULAR AND OTHER DISEASES - Disclosed herein is a method of treating ocular and systemic conditions by administering a TGF-β. | 2011-12-22 |
20110312887 | PROMOTER FOR REGENERATION OF TENDON-BONE JUNCTION TISSUE OR LIGAMENT-BONE JUNCTION TISSUE - An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient:
| 2011-12-22 |
20110312888 | METHOD OF DETECTING AND/OR MEASURING HEPCIDIN IN A SAMPLE - Methods of isolating and/or analyzing hepcidin by mass spectrometry and methods of quantifying hepcidin are disclosed. | 2011-12-22 |
20110312889 | SUSTAINED RELEASE OF MICROCRYSTALLINE PEPTIDE SUSPENSIONS - The invention relates to a fluid, milky microcrystalline aqueous suspension of a peptide or peptidomimetic and a counter-ion of a strong proton donor in water, wherein the peptide or peptidomimetic and counter-ion are present in amounts and at a molar ratio sufficient to form the suspension upon mixing and without formation of a gel. The invention also relates to lyophilized compositions that include a dried suspension, methods of making the lyophilized composition, methods of preparing the suspension, and sustained release formulations prepared by the methods. | 2011-12-22 |
20110312890 | ACETYLATED AMINO ACIDS AS ANTI-PLATELET AGENTS, NUTRITIONAL AND VITAMIN SUPPLEMENTS - This invention relates to pharmaceutical compounds and nutritional supplements that are acetylated derivatives of naturally occurring amino acids and acetylated derivatives of peptides derived from naturally occurring amino acids containing hydroxyl groups. They are as useful as anti-platelet drugs, and as nutritional supplements. | 2011-12-22 |
20110312891 | ENAMEL MATRIX DERIVATIVE FRACTION C - Isolated active compound of a naturally occurring fraction of Enamel Matrix Derivatives (EMD), having at least one of each two N-terminal polypeptide fragments of amelogenin, which are at least 95% identical to an amino acid sequence as shown in SEQ. ID. No:1 and/or 2. The invention relates to the use of said isolated active compound of a fraction and/or of the fraction itself, and/or the at least one of each two polypeptide fragments for use as a medicament and/or for the manufacture of a pharmaceutical composition for a variety of different medical indications such as inducing and/or promoting cementogenesis, bone growth and/or binding between parts of living mineralised tissue, for bonding of a piece of living mineralised tissue to a bonding site on a piece of other living tissue, for endorsing binding between hard tissues, for inducing regeneration of dentin, and/or for filling a mineralized wound cavity and/or tissue defect following from a procedure and/or trauma. | 2011-12-22 |
20110312892 | ANXIOLYTIC COMPOSITIONS CONTAINING ALPHA S1-CASEIN-DERIVED PEPTIDES - The invention relates to pharmaceutical compositions and food products containing peptides derived from the α | 2011-12-22 |
20110312893 | METHOD FOR ISOLATING NEURAL CELLS WITH TENASCIN-R COMPOUNDS - The invention relates to a method for isolating neural cells using tenascin-R compounds, tenascin-R fragments particularly suited for said method and tenascin-R fusion proteins, to recombinant preparation of said tenascin-R compounds, and to a kit for carrying out said method and to the use of said method for preparing high-purity neural cell populations. The invention further relates to antibodies suitable for detecting and isolating tenascin-R compounds. | 2011-12-22 |
20110312894 | METHODS OF DIAGNOSING AND TREATING NEURODEGENERATIVE DISEASES - The present invention relates to methods of diagnosing, treating and prognosing mental disorders, such as Alzheimer's Disease. In one embodiment, the present invention provides a method of treating Alzheimer's Disease by inhibiting dysfunctional signaling of α7 nAChRs in the medial septum region of an individual. | 2011-12-22 |
20110312895 | DIPEPTIDE MIMETICS OF NGF AND BDNF NEUROTROPHINS - The invention relates to compounds having either agonist or antagonist activities for the neurotrophins NGF and BDNF and represented by monomeric or dimeric substituted dipeptides that are analogs of the exposed portions of loop 1 or loop 4 regions of these neurotrophins near or at a beta-turn of the respective loop. N-acylated substituents of these dipeptides are biostereoisomers of the amino acid residues preceding these dipeptide sequences in the neurotrophin primary structure. The dimeric structure is produced advantageously by using hexamethylenediamine to which dipeptides are attached via their carboxyl groups. The claimed compounds displayed neuroprotective and differentiation-inducing activities in cellular models and enhanced the amount of phosphorylated tyrosine kinase A and the heat shock proteins Hsp32 and Hsp70 in the concentration range of 10 | 2011-12-22 |
20110312896 | INHIBITORS OF BCL-2 - A purified polypeptide includes about 5 to about 80 amino acids and includes an amino acid sequence corresponding to a portion of SEQ ID NO:1. The polypeptide inhibiting binding of Bcl-2 to IP | 2011-12-22 |
20110312897 | CATHEPSIN L PROTEOLYTICALLY PROCESSES HISTONE H3 DURING MOUSE EMBRYONIC STEM CELL DIFFERENTIATION - Methods and agents useful for modulating histone proteolysis, stem cell differentiation, and gene transcription and for treating cancer are disclosed. Antibodies or antigen binding fragments that selectively bind to histone-3 cleavage products and are useful for diagnosing cancer and monitoring a subject's response to cancer treatment are also disclosed. | 2011-12-22 |
20110312898 | PROPHYLACTIC / THERAPEUTIC AGENT FOR CANCER - A prophylactic/therapeutic agent for androgen-independent cancer is provided. A prophylactic/therapeutic agent for androgen-independent cancer includes a metastin derivative, and is particularly useful as a prophylactic/therapeutic agent for androgen-independent cancer, in particular, androgen-independent prostate cancer. | 2011-12-22 |
20110312899 | HDL Particles for Delivery of Nucleic Acids - Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits. | 2011-12-22 |