51st week of 2013 patent applcation highlights part 44 |
Patent application number | Title | Published |
20130337394 | HEAT TREATMENT APPARATUS - According to one aspect of the present disclosure, provided is a heat treatment apparatus configured to heat treat a plurality of objects to be treated which are held and supported by a holding and supporting unit while an inert gas is allowed to flow in a vertical type processing chamber from a bottom to a top thereof, wherein the processing chamber has a heating unit installed therearound. The heat treatment apparatus includes a gas supply system configured to supply the inert gas, wherein the gas supply system includes a gas supply header portion located in a lower end of the processing chamber to allow the inert gas to flow along a circumferential direction of the lower end; and a gas introduction portion in communication with the gas supply header portion to introduce the inert gas into the processing chamber. | 2013-12-19 |
20130337395 | PRESSING ARRANGEMENT - The present invention relates to an arrangement for treatment of articles by hot pressing. The pressing arrangement for treatment of articles by hot pressing comprises a pressure vessel including: a furnace chamber comprising a heat insulated casing and a furnace adapted to hold the articles. A heat exchanger unit is arranged below said furnace chamber and adapted to exchange thermal energy with pressure medium when the pressure medium is passing through said heat exchanger unit. According to the present invention, at least one first and second inlet or aperture, respectively, for passage of alternating warm and cold pressure medium are arranged in the heat insulated casing in proximity to the heat exchanger unit (i.e. at approximately same the height as, above or below the heat exchanger unit). The at least one second inlet (or lower inlet) is below the at least one first inlet (or upper inlet) but at same height as or below the heat exchanger unit. | 2013-12-19 |
20130337396 | CRUCIBLE - A graphite crucible has a cylindrical body with an upper opening for receiving a sample for analysis and a disk-shaped pedestal base. The pedestal base includes a bottom surface with a centrally formed circular indentation. An inwardly projecting concave arcuate annular indentation extends between the body and pedestal base with a smoothly curved radius of curvature. The upper and lower walls of the arcuate indentation diverge outwardly at an angle of from about 56 to about 60°. The pedestal base includes a bottom surface with a centrally formed circular indentation. | 2013-12-19 |
20130337397 | Clip-Base-Bracket Assembly Having a Base for an Orthodontic Apparatus and Orthodontic Apparatus Comprising Same - A self-ligating attachment intended to form part of an orthodontic appliance, the external surface of said attachment being provided with a groove for receiving an orthodontic arch. A elastic clip that can be reversibly moved between an open position forming an open passage allowing the insertion of the arch into the groove and a closed position sealing the groove. A base including an external surface that supports the attachment and an occlusal surface which is intended to rest on one of the patient's teeth, so as to hug the surface of the tooth. In addition, the base comprises a support for the attachment and said base assists in the guiding of the clip, cooperating with the attachment, as the clip moves between the open and closed positions. | 2013-12-19 |
20130337398 | Assembly Formed by a Bracket, a Clip and a Base for an Orthodontic Apparatus, and Orthodontic Apparatus Comprising Same - An orthodontic assembly includes a self-ligating attachment having a groove for receiving an orthodontic arch. An elastic clip can be reversibly moved between an open position and a closed position sealing the groove. A base including an external surface and an occlusal surface, said external surface of the base supporting the attachment and said occlusal surface of the base being intended to rest on one of the patient's teeth. The aforementioned clip can be moved in an at least partially rotational manner between the open position and the closed position. Moreover, the area of the above-mentioned base that supports the attachment comprises a depression at least partially in the form of a cup and the clip is inserted into the depression when in the closed position. | 2013-12-19 |
20130337399 | Assembly Formed by a Self-Ligating Bracket and an Elastic Clip, for an Orthodontic Apparatus - An assembly of a self-ligating bracket intended to be part of an orthodontic apparatus. The bracket having in the longitudinal direction thereof an outer face and an occlusal face and being provided on the outer face thereof with a groove for holding an orthodontic arch wire. An elastic clip that can be moved in a reversible manner between an open position, leaving a free passage for the insertion of the arch wire into the groove or the extraction of the arch wire from the groove, and a closed position closing off the groove. The clip being moveable between said positions by a rotational movement, without the clip sliding in translation. | 2013-12-19 |
20130337400 | MARKER FOR IMAGE INFORMATION REGISTRATION - Disclosed is a marker for image information matching. A marker for image information matching in accordance with an embodiment of the present invention is installed in an oral cavity of a patient to provide a reference point for obtaining image information on an oral tissue of the patient. | 2013-12-19 |
20130337401 | METHOD AND DEVICE FOR DETERMINING THE APICAL POSITION IN A DENTAL ROOT CANAL - An apex-locating method and device for determining the depth position of the apex in a dental root canal. It uses a device making it possible to form a circuit including a first probe electrode inserted into the root canal of a tooth, a second electrode in conductive contact with an oral mucous membrane, frequency-generating elements able to produce alternating electrical signals at a number of frequencies, and elements for measuring electrical magnitude of alternating signals in the circuit. Provision is made for exciting the circuit and measuring the levels of magnitude of the alternating signals, respectively at low frequency and at high frequency and for detecting a point of intersection where the two levels measured at low and high frequencies meet and become substantially equal, these frequencies being sufficiently far apart for this point of intersection to exist. This point gives the position of the apex. | 2013-12-19 |
20130337402 | Dental Handpiece with Switching Valve for Fluid Lines - A dental handpiece where the chip air line is selectively switched to the ON-state for using both water and chip air, and to the OFF-state for using only water. The dental handpiece has a switching valve between the circumferential chip air channel and the chip air line in the handpiece body for selectively allowing and preventing communication. Opening the valve switches the communication to the ON-state in which chip air is allowed to pass from the circumferential chip air channel into the chip air line. Closing the valve switches the communication to an OFF-state in which chip air is prevented from passing from the circumferential chip air channel into the chip air line. | 2013-12-19 |
20130337403 | DEVICE AND METHOD FOR TEETH BRIGHTENING - A device for applying a tooth brightening composition to a tooth includes a reservoir fluidly connected to an applicator, where applicator having a factional stress value sufficient to cause mechanical displacement of a biofilm present on a surface of the tooth; a tooth brightening composition disposed within the reservoir; and an activator configured to dispense the tooth brightening composition from the reservoir onto an exterior surface of the applicator. Alternatively or in combination with the above device, the applicator contains pores having a diameter of 0.1-1000 μm. | 2013-12-19 |
20130337404 | Ablation Method and Device - A method comprises inserting an ultrasonic oscillatory dental tip into a gingival sulcus of a patient proximate to a subgingival tooth surface, and ultrasonically oscillating the dental tip while supplying a fluid to a porous of the dental tip to space the dental tip surface from the subgingival tooth surface to inhibit contact there-between while debriding biofilm from the tooth surface. A dental tool comprises a tip body having first and second ends, the first end coupleable to a dental delivery device; an internal fluid flow passage through the tip body disposed between the first end and the second end; the second end having a dental tip surface in fluid communication with the internal fluid flow passage. | 2013-12-19 |
20130337405 | MULTI-LUMEN ASPIRATOR DEVICE - A multi-lumen aspirator device having an elongated body with a plurality of lumens disposed therein for reducing the sound level generated during the operation of the device is disclosed. The elongated body defines a proximal opening that communicates with a distal opening through an inner conduit. The plurality of lumens is disposed within the inner conduit such that a central lumen of the plurality of lumens is surrounded by the remaining plurality of lumens such that laminar flow is established through the multi-lumen aspirator that promotes the reduction in sound generated by the multi-lumen aspirator device during operation. | 2013-12-19 |
20130337406 | SALIVA EJECTOR TIP WITH ON/OFF VACUUM VALVE - A system for removing saliva or debris from the mouth of a dental patient. One end of tubing is connected to a vacuum pump. The other end of the tubing is connected to removably connected tip. A vacuum control valve is connected to the removably connected tip. The vacuum control valve is positioned so that the vacuum control valve remains outside of the patient's mouth when the tip is inserted into to patient's mouth. In a preferred embodiment, the vacuum control valve is a push valve and is located approximately half way along the length of the removably connected tip. In one preferred embodiment the tip is a removably connected saliva ejector tip. In another preferred embodiment the tip is a removably connected high-volume evacuator tip. In another preferred embodiment the tip is a removably connected surgical high volume evacuator tip. | 2013-12-19 |
20130337407 | REAMER ROOT CANAL INSTRUMENT - A dental reamer root canal instrument has a working area that is substantially cylindrical or conical along a longitudinal axis, the instrument including X helical flutes forming X lips of helical cuts, a cut lip being formed by the intersection of two consecutive flutes, wherein X is equal to or greater than three. Over a cross-section of the instrument, the angles (αI, βI, γI) between two consecutive cut lips, measured relative to the longitudinal axis of the instrument, are all different. A method for producing the root canal instrument in a cylindrical or conical rod is also disclosed. The rod is made of a metal or metal alloy material selected for the mechanical bending strength and shape memory properties thereof. The method includes steps for using a grinding wheel to machine a flute to a predefined depth and steps for rotating the rod in front of the machining wheel. | 2013-12-19 |
20130337408 | DENTAL IMPLANT - The invention provides dental implants for fixed and removable prosthetic devices, and for other devices such as orthodontic devices, and has application to single tooth replacement, e.g., caps and crowns, and multiple tooth replacement using one or more implants, e.g., bridges, and multiple implants for full and partial prosthetic devices. Dental implants according to embodiments of the invention comprise a post or posts inserted into the jawbone and a base that is loaded, in the general area of the gum line, against the jawbone using the post or posts. According to some embodiments, the base is secured to each post, loaded against the jawbone, by a fastener system. | 2013-12-19 |
20130337409 | IMPLANT - The present disclopsure relates to an implant, such as a dental implant, having a base member and a thread arranged at an outer end of the base member. The dental implant can be easily inserted and good footing of the implant in the bone can be achieved. Annular ridges and/or recesses can be formed in a section of the base member having no thread. | 2013-12-19 |
20130337410 | INTRA-OSSEOUS IMPLANT - The invention relates to an intra-osseous implant for placement in bone of a human or animal body comprising at least one intra-osseous part intended for placement in said bone tissue having an apical side and a cervical side and composed of a body friendly material, which part is provided on its circumferential surface with a thread running in the direction of the apical end; and a support part present at said cervical side of said at least one intra-osseous part intended for supporting a prosthetic element. The invention aims to provide a medical intra-osseous implant and especially a dental intra-osseous implant, which allows an accurate implant position at a desired depth into bone tissue, providing without losing a high degree of primary implant stability. To this end according to the invention the intra-osseous part is provided with one or more grooves extending in longitudinal direction and interrupting the screw thread into multiple interrupted screw thread parts, said multiple interrupted screw thread parts serving as retention elements allowing the placement of the implant in longitudinal direction into said bone tissue but preventing the removal of the implant in opposite longitudinal direction out of said bone. The invention can also be describes as an intra-osseous implant with along its circumferential surface several rows of retention elements situated in a longitudinal formation. At the same time these retention elements are situated in a screw thread configuration. | 2013-12-19 |
20130337411 | Prefabricated Thermoplastic Partial Denture Clasp with Improved Performance Characteristics and Kit Thereof - A pre-form for making a removable partial dental prosthesis. The pre-form has a tree-shape form having a central body portion and at least one arm extending laterally therefrom and a tail and a head positioned on opposite ends of the arm such that the arm is detachably affixed to the central body portion at the tail. The arm is incorporated into a molding for a removable partial dental prosthesis having a base, an artificial tooth supported by the base and a substantially transparent clasp. The clasp and base are formed to mate with oral mucosa for support of the prosthesis thereon. Also disclosed is a kit for making and inserting a partial dental prosthesis in a gap between natural teeth in a human mouth. | 2013-12-19 |
20130337412 | TOOTH PREPARATION GUIDE DEVICE AND METHOD OF PREPARING TOOTH FOR DENTAL PROSTHESIS - Dental preparation uses a tooth preparation guide custom-made for fitting with teeth of a patient. The preparation guide includes one or more guide channels for guiding a cutting tool. The preparation guide enables modification of the teeth as planned with high level of precision. A dental prosthesis for installing onto prepared teeth of the patient is provided before preparation of the teeth. The prosthesis includes features that are complementary to the prepared teeth. The prosthesis can be installed immediately after preparing the teeth using the preparation guide. With the high level of accuracy and precision in the preparation of teeth, no modification of the prosthesis would be needed for installation. | 2013-12-19 |
20130337413 | Method Of Powder Blasting For Cleaning Of Tooth Surfaces - A method for cleaning tooth surfaces with a powder and a powder mixture, preferably by powder blasting with a powder-jet device, said device mixing the powder or the powder mixture with air to form a powder/air mixture, wherein said powder and/or powder mixture is an alditol or contains such alditol. Preferably, mannitol and/or erythritol are used, because of their anti-cariogenic effect. Xylitol is also suitable for cleaning tooth surfaces, especially of less strongly mineralized tooth surfaces like dentine. | 2013-12-19 |
20130337414 | DENTAL ROOT CANAL FILLING MATERIAL HAVING IMPROVED THERMAL CONDUCTIVE CHARACTERISTICS - A root canal filling material incorporates heat conductive particles of sub-micron size dispersed in a heat flowable matrix of endodontic filling material. The particle size is 1 micron or less (e.g., 0.5 to 1 micron, or nanoparticles of 100 nm or less). The addition of high heat conductive particles in the heat flowable matrix material improves the overall heat conductivity of the root canal filling material. During root canal treatment procedure, the filling material softens more thoroughly to fill the root canal apex and to form a seal of higher integrity at the root canal apex area, at a significantly lower operating temperature. The inventive filling material may be provided in bulk (e.g., pellet form) for use with an injection tool that heats and injects softened filling material into root canal cavities, or pre-shaped in the form of dental root canal filling cones (or points). | 2013-12-19 |
20130337415 | FIREARM TRAINING SYSTEM - A firearm training system, comprising a firearm and a training module mechanically coupled with the firearm that operates to train a user to accurately fire a firearm to a target. The training module includes communication circuitry and at least one of an inertial measurement unit (IMU) and an attitude and heading reference system (AHRS). The system includes a feedback unit that communicates with the training module by way of the training module communication circuitry. The feedback module is configured to receive position information from the training module and to generate feedback data and user feedback in the form of a tone or light or speech. In one embodiment, the training module generates feedback for the user. Typically, the feedback is generated to indicate movement in relation to a desired aim point. | 2013-12-19 |
20130337416 | VIDEO CAPTURE, RECORDING AND SCORING IN FIREARMS AND SURVEILLANCE - A video camera and recording device integrated with a real or toy weapon to provide video recording of the assault and aiming process of the weapon holder in operational training, actual combat, hunting, sports and gaming scenarios. A video camera is boresighted with the weapon, and a video memory stores the recorded dynamic scenario, and a trigger sensor which continually senses and records the triggering actions imposed by the weapon holder. The trigger sensor is attached to the actual trigger of the weapon thus enabling normal operation of the weapon. The video camera, may be mounted internally within the bore of the weapon, such that the external form of the weapon is not altered, thus achieving closer operation to real life situations. The recorded trigger data is utilized upon playback of the recorded video, enabling quick review and scoring of the recorded aiming process for training and gaming. | 2013-12-19 |
20130337417 | Online Method for Training Vehicle Drivers and Determining Hazard Detection Proficiency - A method for training vehicle drivers to detect hazards, the method having step that include: visually presenting to a driver a continuous drive through a driving environment comprised of at least two hazard modules, wherein each hazard module presents at least one driving scenario that comprises at least one hazard; recording where within the visual presentation the driver looks to detect hazards during the visual presentation of the continuous drive; and determining the driver's hazard detection proficiency by evaluating whether the driver looked at hazards during the visual presentation of the continuous drive. | 2013-12-19 |
20130337418 | PROCESS OF FLORAL BOTANICAL COLLAGE DECOUPAGE - An improved process for dry flower craft which comprises cutting craft media (dry botanicals with stencils) and mounting the same on any surface of product with combination of other botanical elements like bamboo, grass, weeds, seed, stem, tendrils, fiber, solawood in any desired manner including artistic manner, which comprises reducing color loss while drying and storage of vegetation and also during crafting of the vegetation, making stencils of cheapest materials such as cardboard and paper, cutting out motifs; shaping the petals in any desired shape, pasting the same with known adhesives, characterized in that botanicals are dried prior to floral collage decoupage by drying while using mixture desiccant of silica gel+silver sand+non iodised salts (1:1:1 ratio), finally obtaining floral decoupage or only floral collage or a combination of both in design processing as application of the craft, making the floral resin laminates by reducing the peroxide harder by 1%. | 2013-12-19 |
20130337419 | Method for Assisting in Weight Loss - A method that assists in weight loss includes distributing at least one plate to a user. The plate has a maximum dimension of no more than 10 inches, and a top surface that includes visual indicia representing a pattern defining four parts of equal area on the top surface in a discreet manner that avoids any indication of distribution of food groups over the parts of the plate. The method further includes distributing use instructions that recommend the distribution of food groups of a meal to be eaten on the plate over the four parts of the top surface as defined by the pattern. The pattern is preferably symmetrical about two orthogonal axes that cross one another at or near the center of the top surface of the plate, and has a luxurious style that cooperates with its discreet nature to allow for multiple purpose uses (including everyday use, entertaining, and/or portion control/dieting). | 2013-12-19 |
20130337420 | Recognition and Feedback of Facial and Vocal Emotions - An approach is provided for an information handling system that identifies emotions and notifies a user that may otherwise have difficulty identifying the emotions displayed by others. A set of real-time inputs, such as audio and video inputs, are received at one or more receivers. The inputs are received from a human subject who is interacting with a user of the information handling system with the information handling system being a portable system carried by the user. The received set of real-time inputs are compared to predefined sets of emotional characteristics in order to identify an emotion that is being displayed by the human subject. Feedback is provided to the user of the system regarding the identified emotion exhibited by the human subject. | 2013-12-19 |
20130337421 | Recognition and Feedback of Facial and Vocal Emotions - An approach is provided for an information handling system that identifies emotions and notifies a user that may otherwise have difficulty identifying the emotions displayed by others. A set of real-time inputs, such as audio and video inputs, are received at one or more receivers. The inputs are received from a human subject who is interacting with a user of the information handling system with the information handling system being a portable system carried by the user. The received set of real-time inputs are compared to predefined sets of emotional characteristics in order to identify an emotion that is being displayed by the human subject. Feedback is provided to the user of the system regarding the identified emotion exhibited by the human subject. | 2013-12-19 |
20130337422 | SURFING DEVICE AND METHOD - The present Invention provides a surfing device comprising at least one energy projecting means and at least one energy projecting structure for supporting and positioning the energy projecting means. The energy projecting structure positions the energy projecting means at one or more energy projecting positions. Energy is projected from the energy projecting means from positions to enable a person to surf at least partially solely via the projected energy. The present invention also provides a surface for a surfing device, either the device of the present Invention or another surfing device. The surface, is designed for a person to surf on either via the projected energy of the surfing device of the present Invention or by at least partially direct contact with the surface via fluid projected out of, over or upon it. The surface has an Impact absorption material. The material Is at (east partially porous and at least partially deformable and also designed to at least partially deform upon impact to at least partially absorb or diffuse the impact. | 2013-12-19 |
20130337423 | METHOD FOR RELIEVING A PARTIAL AIRWAY OBSTRUCTION CAUSED BY A FOREIGN OBJECT - A method of breathing for a choking victim is disclosed, which allows the person to produce a forceful cough for relieving a partial upper airway obstruction caused by a foreign object. When a choking victim is able to move air and cough, the method of sitting or standing erect and inhaling air through the nose can be used to fill the lungs to the point where a powerful cough can be generated to relieve the obstruction. This posture allows inhalation of air through the nasopharynx in order to entrain a large volume of air into the lungs, and further allows the lungs to fully expand and the accessory expiratory muscle to better assist the diaphragm in forced expiration. In this manner, the victim can generate a cough having an expiratory force sufficient to dislodge a foreign object from the upper airway. | 2013-12-19 |
20130337424 | SPLIT IMAGE SHOE INDICATOR SYSTEM AND METHOD OF USE - A system and method for indicating which shoe goes upon which foot. The system includes a pair of shoes and a single image that is easily discernible by children and those with diminished capacities. The image is split into a left portion and a right portion. The image is one that children who may lack certain cognitive abilities are able to easily form the two pieces of the image into a single image, like a puzzle. The left portion of the image is placed on the left shoe and the right portion of the image is placed on the right shoe. This can be accomplished by printing the split image directly on the soles of the shoes or shoe sole inserts themselves. This provides the advantage of indicating which shoe is the left shoe and which shoe is the right shoe. | 2013-12-19 |
20130337425 | Fetal Sonography Model Apparatuses and Methods - This disclosure includes embodiments of apparatuses and methods for simulating the uterus of a human (e.g., for training medical providers to perform sonograms, amniocentesis, ultrasound-guided amniocentesis, and/or other procedures). For example, in at least some embodiments, the apparatus comprises a container with a compartment and an anterior wall that is configured to permit sonogram imaging of the compartment. In some embodiments, the apparatus comprises a container that is configured to be removably coupled to the abdomen of a live human or human model such that the compartment simulates the uterus of the human or model. | 2013-12-19 |
20130337426 | AUTOMATIC VOTING AMONG SMALL SUBSETS OF CONTESTANTS - A method of surveying a population of voters concerning a pool of contestants to obtain a consensus comprises generating a digital list of all possible pairs, triplets or quadruplets of contestants in the pool and/or sublist of such small subsets of contestants in a subpool such as a social network, presenting to voters in the population at a web site each small subset of contestants in the digital list and/or digital sublist, and for each small subset of contestants presented prompting the voter to select a preferred contestant among the contestants that appear in the small subset of contestants. The voters may also be contestants. A tally of preferred contestants among all voters is assembled as is a tally among contestants from the subpool, and contestants may be ranked. The voting may be applied to costume contests, pet contests, political elections, market surveys and other data collection methods. | 2013-12-19 |
20130337427 | ELECTRONIC BOOK, METHOD AND DEVICE FOR IDENTIFYING ELECTRONIC BOOK PAGE NUMBER - Disclosed are an electronic book, as well as a method and device for identifying electronic book page numbers. The method includes positioning trigger pins and a contact end on a book spine. The contact end is electrically connected to a controller. When a page of the electronic book is flipped, two contact ends of a soft circuit, which is closely affixed on the book spine, are made conducting by squeezing a positioning trigger pin. The conduction signal of the contact ends are received and the page number of the flipped page is identified according to the received signal. The preset content of the book page is played through the controller which is electrically connected to the soft circuit. Positioning trigger pins and the contact end are arranged on the low parts of the book spine surface, which is formed naturally by mounting and bending pages. | 2013-12-19 |
20130337428 | LEARNING CONCEPT ORGANIZER - The present invention is a learning organizer for assisting a learner. The learning organizer comprises a sheet having a front portion and a rear portion, the sheet folded substantially along a central line to form a first half and a second half, a plurality of flaps located on the first half, a plurality of holes provided along and proximate to the central line and punched through the first half and the second half, a plurality of lines on the rear portion and a plurality of fill-in-blanks pre-printed on the second half to write details of the learner. Each of the plurality of flaps includes a plurality of perforations and a plurality of scorings. The plurality of lines is provided for neat writing. The learning organizer allows the learner to write down learning information into each of the plurality of flaps so as to present, organize, learn and memorize learning concepts. | 2013-12-19 |
20130337429 | INTERNET BASED LEARNING SYSTEMS - A learning system is adapted to provide a learning management system adapted to present an exercise environment to the user in which the user is able to practice skills through a combination of presented media and practice areas. The learning system is adapted to provide feedback to the user during the practice session to allow the user to improve performance while in the exercise environment. Additionally, the learning system is adapted to track the user's performance in terms of practice time and in terms of accuracy percentage to allow the student and the educator to monitor performance related to effort. Still additionally, the learning systems of the present disclosure may be adapted to track the types of errors committed by the users to enable the users and educators to provide more directed educational experiences and practice sessions to overcome recurring problems. | 2013-12-19 |
20130337430 | SELF-ORGANIZING TECHNOLOGY FOR DISASTER RESPONSE AND RECOVERY - People facing emergencies, such as disasters, may not receive external assistance in a timely manner, instead having to rely on themselves for critical or extended periods. A system including emergency response containers providing both for organizational structure, including a method of assigning roles to available individuals, and task domain knowledge for organizational elements, namely the people facing and experiencing the emergency, allows for organic emergency response and eases transition to and effectiveness of external professional emergency response providers. In some embodiments the system is modular and adjustable for different situations. | 2013-12-19 |
20130337432 | DIAGNOSTIC SYSTEMS AND CARTRIDGES - In particular, a disposable cartridge is disclosed that is suitable for use with a clinical or diagnostic point-of-care device and capable of performing diagnostic and analytical functions including filtering samples such as plasma from whole blood and running assays and collecting measurements of analytes or biomarkers. | 2013-12-19 |
20130337433 | PROCESS FOR PRODUCING THREE-DIMENSIONAL TISSUE - The invention provides a process for producing a three-dimensional tissue by cultivating eucaryotic cells by introducing the cells into a matrix and cultivating the cells within the matrix in a cell culture medium within a cell culture vessel under controlled dissolved oxygen conditions of the cell culture medium. The matrix contains a support containing an optical oxygen sensor, which is an oxygen-sensitive dye, which upon irradiation with an excitation wavelength changes its emission characteristics in dependence on the dissolved oxygen concentration in the surrounding medium, including a dye phosphorescing upon irradiation of an excitation wavelength, which phosphorescence is quenched by dissolved oxygen. | 2013-12-19 |
20130337434 | Method of Preparing Magnetic Bead Type Nasopharyngeal Enzyme Immunoassay Reagents by Polymerase Chain Reaction - A method of preparing magnetic bead type nasopharyngeal enzyme immunoassay reagents by polymerase chain reaction according to this invention offers in-vitro diagnostic reagents by means of utilizing nanotechnology. This method uses magnetic beads to coat EBV nuclear antigen (Epstein-Barr virus nuclear antigen, EBNA1) or early antigen (Early Antigen, EA). The use of polymerase chain reaction (polymerase Chain Reaction PCR) is for amplified detection. It is found that positive controls of different concentrations, after amplified by PCR, change in their brightness and concentration. That reveals the EBV antigens on the magnetic beads can specifically detect IgA antigens in the serum. | 2013-12-19 |
20130337435 | M13 Bacteriophage as a Chemoaddressable Nanoparticle for Biological and Medical Applications - Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding. | 2013-12-19 |
20130337436 | SUBSTRATE COATED WITH NANOPARTICLES, AND USE THEREOF FOR THE DETECTION OF ISOLATED MOLECULES - The present disclosure relates to a substrate having a surface comprising nanoparticles or groups of nanoparticles which the linear optical response does not depend on the polarisation of the incident field of a Gaussian beam having an axis of propagation that is directed perpendicularly to the surface of the substrate. The shape or arrangement of the groups of nanoparticles has a Cn-type axis of symmetry perpendicular to the surface, where n is a number equal to three or greater than four, and the shape of the nanoparticles has a Cn-type axis of symmetry perpendicular to the surface, where n is a number no less than three, to allow strong enhancement of the beam close to the surface. The disclosure relates to use of substrates for detection and/or measurement of chemical, biochemical or biological molecules, wherein the molecules can be present in trace amounts in a liquid or other medium. | 2013-12-19 |
20130337437 | PROCESS FOR DETECTING CELLS FROM A SAMPLE - A process for detecting cells from a sample, comprising the following steps:
| 2013-12-19 |
20130337438 | MONOCLONAL ANTIBODY RECOGNIZING HUMAN PAPILLOMAVIRUS (HPV) L2 PROTEIN AND METHOD FOR MEASURING HPV-NEUTRALIZING ANTIBODY TITER USING THE SAME - The present invention relates to the development of a monoclonal antibody which has binding activity to many high-risk types of HPV, etc. The present invention also provides a simple and high-throughput method for measuring cross-neutralizing antibody titers, which is used for assay of cross-neutralizing antibody against HPV in serum samples from subjects, etc. The method of the present invention for measuring cross-neutralizing antibody titers comprises the steps of: preparing a monoclonal antibody against a peptide having a specific amino acid sequence common to high-risk types of HPV; and assaying cross-neutralizing antibody using this monoclonal antibody. | 2013-12-19 |
20130337439 | PORTABLE DEVICE FOR THE STORAGE, TRANSPORT AND RECUPERATION OF BIOLOGICAL MATERIAL - The present invention refers to a portable device for the collection of biological samples. The device comprises a receptacle ( | 2013-12-19 |
20130337440 | METHODS FOR MICROVESICLE ISOLATION AND SELECTIVE REMOVAL - The invention relates to compositions and methods for isolation of microvesicles produced by mammalian cells. These microvesicles, known as extracellular microvesicles or circulating microvesicles, are isolated from sample materials such as body fluids, or from cell culture media that has been used to culture and maintain mammalian cells in vitro. The isolation of microvesicles as described herein results in purification and concentration of the microvesicles. | 2013-12-19 |
20130337441 | COMBINED HISTOLOGICAL STAIN - The present invention relates to methods of visualizing targets in histological samples, e.g. biopsy samples, wherein the methods comprise staining of the sample with (i) one or more target specific immunochemical stains, and (ii) a histological stain for specific tissue components e.g. iron, mucins glycogen, amyloid, nucleic acids, etc., e.g. hematoxilyn and/or eosin stains or the like, that is used to enhance contrast in the microscopic image of a tissue sample, highlight morphologic structures in the sample for viewing, define and examine tissues, cell populations, or organelles within individual cells. Methods may further comprise evaluation of expression of one or more targets in the sample. The disclosed methods are useful for medical diagnostics. | 2013-12-19 |
20130337442 | GENETIC LOCI ASSOCIATED WITH SOYBEAN CYST NEMATODE RESISTANCE AND METHODS OF USE - Various methods and compositions are provided for identifying and/or selecting soybean plants or soybean germplasm with improved resistance to soybean cyst nematode. In certain embodiments, the method comprises detecting at least one marker locus that is associated with resistance to soybean cyst nematode. In other embodiments, the method further comprises detecting at least one marker profile or haplotype associated with resistance to soybean cyst nematode. In further embodiments, the method comprises crossing a selected soybean plant with a second soybean plant. Further provided are markers, primers, probes and kits useful for identifying and/or selecting soybean plants or soybean germplasm with improved resistance to soybean cyst nematode. | 2013-12-19 |
20130337443 | METHODS FOR DETECTING DNA PRIOGINATING FROM DIFFERENT INDIVIDUALS - In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample. | 2013-12-19 |
20130337444 | NANO46 Genes and Methods to Predict Breast Cancer Outcome - The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention. | 2013-12-19 |
20130337445 | METHOD FOR THE CLINICAL DEVELOPMENT AND MEDICAL APPLICATION OF MULTIPLEX ASSAYS DERIVED FROM PATTERNS OF INDIVIDUAL BIOMARKERS OF OXIDATIVE OR NITROSATIVE STRESS - A method and apparatus for the discovery, development and clinical application of multiplex synthetic assays based on patterns of free radicals, indicators of oxidative or nitrosative stress, or indicators of the redox state of biologic fluids and tissue specimens. These individual measurements are combined into an optimized clinical biomarker using known well-known mathematical, machine learning techniques. | 2013-12-19 |
20130337446 | METHOD OF PREPARING A STANDARD DIAGNOSTIC GENE TRANSCRIPT PATTERN - A method for preparing a gene transcript pattern probe kit characteristic of a disease or condition or a stage thereof in a prokaryotic or eukaryotic organism using mRNA which is differentially expressed in the disease or condition or stage as probes, methods of diagnosis using the method and kits for performing the same are disclosed. | 2013-12-19 |
20130337447 | METHODS AND COMPOSITIONS FOR EVALUATING GENETIC MARKERS - Aspects of the invention relates to methods and compositions that are useful to reduce bias and increase the reproducibility of multiplex analysis of genetic loci. In some configurations, predetermined preparative steps and/or nucleic acid sequence analysis techniques are used in multiplex analyses for a plurality of genetic loci in a plurality of samples. | 2013-12-19 |
20130337448 | Method and Kit for Determining Severity and Progression of Periodontal Disease - An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease. | 2013-12-19 |
20130337449 | MARKER FOR PREDICTING GASTRIC CANCER PROGNOSIS AND METHOD FOR PREDICTING GASTRIC CANCER PROGNOSIS USING THE SAME - The present invention relates to a marker for predicting a gastric cancer prognosis, a composition and a kit for predicting gastric cancer prognosis comprising an agent for measuring the expression level thereof, and a method for predicting gastric cancer prognosis using the marker. According to the present invention, gastric cancer prognosis may be predicted promptly and accurately, and an appropriate treatment plan can be determined based on the predicted prognosis, which has an advantage of contributing to significant reduction of death caused by gastric cancer. Particularly, according to the present invention, the survival rate can be remarkably increased by using the treatment method for a stage III gastric cancer patient to a patient who has been predicted to have a negative prognosis among stage Ib/II gastric cancer patients. | 2013-12-19 |
20130337450 | DETECTION OF QUANTITATIVE GENETIC DIFFERENCES - The present invention relates to uses and methods for the detection of a quantitative difference between first and second target sequence regions present in a nucleic acid sample, in particular but not exclusively a DNA sample, and a kit for carrying out the uses and methods of the invention. | 2013-12-19 |
20130337451 | METHOD FOR DETECTING METHYLATED CYTOSINE - The invention provides a method for obtaining DNA after bisulfite reaction which can be stored with libraries in genome reserved and has excellent storage stability, and a method for detecting methylated cytosine. Specifically, the invention provides a method for obtaining DNA complementary to single-stranded DNA in which non-methylated cytosine has been uracilated by subjecting single-stranded DNA to a bisulfite reaction and then a reverse transcriptase reaction. The resulting complementary DNA can be amplified by a PCR reaction. Methylated cytosine can be detected in single-stranded DNA by subjecting the single-stranded DNA, in order, to a bisulfite reaction, a reverse transcriptase reaction, and a PCR reaction, and then subjecting the obtained PCR amplification product to nucleotide sequence analysis. | 2013-12-19 |
20130337452 | Methods For Rapid Forensic Analysis Of Mitochondrial DNA - The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database. | 2013-12-19 |
20130337453 | EXTRACELLULAR MITOCHONDRIA-BASED SCREENING AND TREATMENT - Based on novel findings that mitochondrial dynamics regulate mast cell secretion of pre-stored TNF stimulated by SP, novel methods and compositions related to extracellular mitochondrial DNA (mtDNA) are provided for the diagnosis and treatment of diseases brought on by malfunctioning immune activities, e.g., inflammatory, autoimmune diseases, and neurodegenerative diseases such as ASD. | 2013-12-19 |
20130337454 | METHOD FOR INCREASING THE EFFICIENCY OF DOUBLE-STRAND BREAK-INDUCED MUTAGENESIS - The present invention relates to a method for increasing double-strand break-induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns a method for increasing double-strand break-induced mutagenesis at a genomic locus of interest, leading to a loss of genetic information and preventing any scarless re-ligation of said genomic locus of interest by NHEJ. The present invention also relates to engineered endonucleases, chimeric or not, vectors, compositions and kits used to implement this method. | 2013-12-19 |
20130337455 | Multi-Mode Separation for Target Detection and Cell Growth Monitoring - Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual physical properties, namely magnetism and buoyancy. Sandwich separation is highly specific, allows for removal of the beads that do not have any attached target, and reduces the number of background beads. Sandwich separation can also be used to allow for target detection in raw specimen. Also, improvement of detection capability is accomplished by performing AMBR measurements on a solid interface, where the rotational period speeds up and allows for dramatically reduced time-to-result. | 2013-12-19 |
20130337456 | COMPARATIVE SEQUENCE ANALYSIS PROCESSES AND SYSTEMS - Provided herein are processes for rapidly identifying or determining sequence information in a sample nucleic acid by comparing sample nucleic acid sequence information to reference nucleic acid sequence information or information obtained from reference samples. Also provided are automated systems for conducting comparative sequence analyses. | 2013-12-19 |
20130337457 | Multilevel Microfluidic Systems and Methods - Multilevel microfluidic devices include a control line that can simultaneously actuate valves for both sample and reagent lines. Microfluidic devices are configured to contain a first reagent in a first chamber and a second reagent in a second chamber, where either or both of the first and second reagents are contained at a desired or selected pressure. Operation of a microfluidic device includes transmitting second reagent from the second chamber to the first chamber, for mixing or contact with the first reagent. Microfluidic device features such as channels, valves, chambers, can be at least partially contained, embedded, or formed by or within one or more layers or levels of an elastomeric block. | 2013-12-19 |
20130337458 | Human trophoblast stem cells and and methods of therapeutic screening - Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. These facts suggest that differentiation of the hTS cells play an important role in implantation and placentation. hTS cells could be apply to human cell differentiation and for gene and cell-based therapies. | 2013-12-19 |
20130337459 | A METHOD OF ENHANCING MIR-185 EXPRESSION TO REDUCE LOW DENSITY LIPOPROTEIN/CHOLESTEROL ACCUMULATION IN A CELL - The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans. | 2013-12-19 |
20130337460 | Methods and Compositions for Segregating Target Nucleic Acid from Mixed Nucleic Acid Samples - The invention provides methods, compositions and kits for segregating a target nucleic acid from a mixed nucleic acid sample. The methods, compositions and kits comprise a non-processive endonuclease (e.g., a restriction enzyme) or an antibody that binds the target nucleic acid (e.g., has methylation specificity). The mixed nucleic acid sample can comprise prokaryotic and eukaryotic nucleic acid and/or nucleic acid from more than one prokaryotic or eukaryotic organisms. | 2013-12-19 |
20130337461 | METHOD FOR DIAGNOSIS, MONITORING THE EFFICACY OF A THERAPY AND FOR DEVELOPMENT OF TREATMENT FOR MULTIPLE SCLEROSIS - The present invention relates to a method for diagnosis and/or prognosis of multiple sclerosis or to monitor the efficacy of a therapy and/or to screen for a treatment for multiple sclerosis comprising measuring the amount or assessing the cellular localization of one or more specific molecular species in stimulated oligodendrocyte cells. | 2013-12-19 |
20130337462 | EXTRACTION OF NUCLEIC ACIDS - The invention relates to a nucleic acid extraction material which comprises at least one ion exchange material and PVPP. | 2013-12-19 |
20130337463 | Cell-Based Models of Neurodegenerative Disease - The present invention relates to a cell-based model useful for identifying molecules that modify intracellular pathways of α-synuclein and tau aggregation and degradation. | 2013-12-19 |
20130337464 | ARSENIC ASSAY USING ELISA - The invention relates to a process involving analyzing the presence of arsenic in a sample, comprising the following steps:
| 2013-12-19 |
20130337465 | METHOD FOR ENUMERATION OF MAMMALIAN CELL MICRONUCLEI, WHILE DISTINGUISHING CHROMATIN OF DEAD AND DYING CELLS - The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed. | 2013-12-19 |
20130337466 | METHOD FOR DIAGNOSING ALZHEIMER'S DISEASE USING BIOMATERIAL - Provided is a method for diagnosing Alzheimer/s disease using a decomposed biomaterial. The method includes: preparing magnetic particles on which primary capture antibodies specifically bound to beta-amyloid are adsorbed; decomposing a biomaterial including beta-amyloid; binding the beta-amyloid to the primary capture antibodies; binding secondary capture antibodies labeled with a fluorescent material to the magnetic particles bound to the beta-amyloid to form a complex; disposing the complex in a channel region of a photo field effect transistor in which a photocurrent is changed according to the amount of incident light; and measuring the photocurrent changed by light excited from the complex to quantify the concentration of the beta-amyloid existing in the biomaterial. | 2013-12-19 |
20130337467 | P28GANK MONOCLONAL ANTIBODY AND PEPTIDES FOR PREPARATION THEREOF AND USE THEREOF - The invention provides the sequences of two polypeptides comprising the amino acid sequences as shown in SEQ ID NO:1 and SEQ ID NO:2, which can be used for the preparation of monoclonal antibodies against human p28 | 2013-12-19 |
20130337468 | COMPETITIVE BIOSENSOR HAVING ELEVATED SENSITIVITY - The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject. | 2013-12-19 |
20130337469 | METHOD FOR DETECTING A TARGET MOLECULE IN A BIOLOGICAL SAMPLE - A method is provided for detecting a target molecule in a biological sample. One step of the method includes immobilizing the biological sample on a membrane. Next, the membrane-bound biological sample is contacted with at least one detection moiety. The membrane-bound biological sample is then separately mated with a substrate and the target molecule detected. At least one step of the method is performed under positive pressure or a vacuum. | 2013-12-19 |
20130337470 | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMadCAM LEVELS - Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAd-CAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation. | 2013-12-19 |
20130337471 | CELL IDENTIFICATION WITH NANOPARTICLES, COMPOSITIONS AND METHODS RELATED THERETO - The present disclosure provides a method for identifying rare or low-abundant biological entities such as Hodgkin's and Reed-Sternberg cells, circulating tumor cells in peripheral blood, circulating fetal cells, stem cells, somatic cells, HIV-infected T cells, bacteria or viruses in water, adenoviruses, enteroviruses, hepatitis A and E, dengue, Swine Flu, bovine diarrhea, and protozpa/helminthes. The method uses a suite of nanoparticle-conjugated agents to mark biological targets of interest for subsequent fluorescence imaging. In certain embodiments, the nanoparticle-conjugated agents are fluorescent semiconductor nanocrystals conjugated with antibodies with affinity for CD15, CD30, CD45, and Pax5. In certain embodiments, a method is developed to differentiate Hodgkin's and Reed-Sternberg (HRS) cells from amongst surrounding immune cells such as T and B lymphocytes with greater specificity and precision than traditional immunohistochemistry (IHC) for the diagnosis of Hodgkin's lymphoma. | 2013-12-19 |
20130337472 | CELL DIVISION MARKER - This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and persists through multiple subsequent cell cycles. The midbody scar can be useful as a marker of dividing cells or of a cell's replicative age. | 2013-12-19 |
20130337473 | CELL IDENTIFICATION SYSTEMS AND METHODS USING FUNCTIONALIZED MICROPALLET ARRAYS - Cell identification systems and methods using micropallet arrays are disclosed. According to one embodiment, a cell identification strategy involves detecting the expression patterns of markers that are expressed on cells to uniquely identify different cell populations within heterogeneous mixtures of cells. The cell markers may be on the cell surface or intracellular in location. The cell markers are interrogated using monoclonal antibodies (mAbs) that are directly conjugated to flourophores. The mAb-flourophore conjugates are used to detect the presence or absence and relative level of expression of each of the cell markers using laser scanning confocal microscopy. | 2013-12-19 |
20130337474 | DETECTION OF ACUTE MYELOID LEUKAEMIA - The present invention relates to diagnostic screens, antibodies, methods and kits for detection/prognosis of acute myeloid leukaemia. The diagnostic screen detects the presence (+) or absence (−) of the cell surface polypeptide markers i) CD34+; ii) CD45RA+; and iii) CD90− and/or CD123+. Antibodies specific for one or more of said cell surface polypeptide markers may be used in the diagnostic screen of the invention. Diagnostic and prognostic methods for detecting and monitoring minimal residual disease based on said screen also form part of the invention. | 2013-12-19 |
20130337475 | DETECTION TARGET SUBSTANCE DETECTING METHOD, DETECTION TARGET SUBSTANCE DETECTING CHIP USED IN THE METHOD, AND DETECTION TARGET SUBSTANCE DETECTING APPARATUS - Expedient and sensitive detection of a detection target substance is enabled in target substance detection that detects the detection target substance at a sensor portion provided within a flow channel. A detection target substance detecting method for a detecting detection target substance which may be contained in a liquid sample emits ultrasonic waves that propagate in a direction transverse to a flow channel when the liquid sample flows within a ultrasonic wave emission region at which ultrasonic waves can be emitted, to concentrate the detection target substance at a wall surface of the flow channel toward the side of the sensor portion and to detect the detection target substance. | 2013-12-19 |
20130337477 | Distributable Chemical Sampling and Sensing System Process - The present invention relates to the use of a distributable sampling and sensing system for the determination of volatile components of consumable foods and other agricultural products. This process is used to separate and concentrate the chemicals of interest from samples at remote locations onto a target substrate that can be analyzed on-site or at a central lab. The chemicals deposited onto the substrate can be analyzed on-site with specific sensors (e.g., electrochemical sensors) or the target substrate can be sent to a central lab where the components adsorbed within are analyzed with conventional chemical instrumental methods (e.g., GC-MS). This process provides sufficient flexibility to enable the chemical analysis of a wide range of chemical species of interest in target materials in remote locations. | 2013-12-19 |
20130337478 | Antigen-Binding Protein Directed Against Epitope in the CH1 Domain of Human IgG Antibodies - The present disclosure relates to a method for the purification of a human IgG-CH1 domain comprising molecule using an antigen-binding protein that is capable of binding to an epitope that is comprised in the CH1 domain of each of human IgG1, human IgG2, human IgG3 and human IgG4. The disclosure further relates to the antigen-binding proteins that can be used in the method of the disclosure. The frame-work regions of the antigen-binding proteins of the invention preferably correspond to those of antibodies that naturally are devoid of light chains as may e.g. be found in camelids. The disclosure further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, and to the uses of such immunoadsorbent materials for the purification of IgG-CH1 domain containing molecules from a variety of species. | 2013-12-19 |
20130337479 | BIOMARKER FOR COGNITIVE DYSFUNCTION DISEASES, AND METHOD FOR DETECTION OF COGNITIVE DYSFUNCTION DISEASES USING THE BIOMARKER - The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker. | 2013-12-19 |
20130337480 | CHEMILUMINESCENCE-BASED HAEMOSTASIS ASSAY - The present invention relates to a method for in vitro determining generation of a haemostatis factor such as thrombin and/or plasmin in a test sample using a chemiluminescent substrate specific for said blood clotting factor. Upon cleavage of the substrate, a luminescent signal is generated via aminoluceferin with the aid of a luciferase. The invention also relates to a kit for in vitro determining generation of a haemostasis factor in a test sample, and to novel chemiluminescent substrates for the determination of thrombin and plasmin. | 2013-12-19 |
20130337481 | ASSAY METHOD - The invention provides an assay method for determining a level of haptoglobin in a sample comprising the steps of: (i) mixing haemoglobin with the sample to be assayed so as to form a haptoglobin-haemoglobin complex with haptoglobin present in the sample; (ii) contacting the product of step (i) with reagents for generating hydrogen peroxide and one or more chromogens which undergo a spectroscopically detectable change when peroxidase activity is present, in the presence of a buffer, under conditions in which hydrogen peroxide is generated from said reagents and forms a substrate for the peroxidise activity of the haptoglobin-haemoglobin complex present, and wherein the pH of the buffer is within a range which is sufficiently low that the peroxidise activity of any uncomplexed haemoglobin is substantially suppressed but sufficiently high that hydrogen peroxide generation occurs; (iii) determining the peroxidase activity of the haptoglobin-haemoglobin complex by measuring the change in an optical property of the reaction mixture; and (iv) correlating the level of peroxidise activity of the haptoglobin-haemoglobin complex with the amount of haptoglobin in the sample. A kit for use in such a method is also provided. | 2013-12-19 |
20130337482 | ASSAYS AND KITS TO DETERMINE GALACTOCEREBROSIDASE ACTIVITY ON SOLID SUPPORT - The present invention discloses compositions, methods, assays and kits which provide for rapid, high-throughput and sensitive assays useful for detecting the activity of galactocerebrosidase (GALC) in a test sample. The methods, assays and kits of the present invention provide useful diagnostic tools which may be used to identify subjects suspected of having an enzyme deficiency and to evaluate the efficacy of enzyme replacement therapy. | 2013-12-19 |
20130337483 | SYSTEMS AND METHODS FOR FEEDSTOCK QUALITY ASSESSMENT - Assessing quality of feedstock is provided and may be useful for determining quality of feed (such as corn kernels). The assessment determines endogenous enzyme activity within the feedstock, which correlates with total ethanol yields in raw starch hydrolysis (non-cooked) systems. In some embodiments, a sample containing flour (ground feedstock) is provided. In some cases, flour is diluted in water and buffered with a phosphate buffered solution. The buffered flour solution is contacted with a molecule, or fluorescent dye, such as fluorescein diacetate and/or difluorofluorescein that is altered by enzymatic (esterase) activity in a detectable fashion. Enzyme activity may be facilitated using an incubator. The detectible alteration may be measured using a fluorometer. In some embodiments, two incubations and fluorescence measurements can be performed. By subtracting the difference between the measured fluorescence, a fluorescence index may be found, which correlates with the endogenous enzyme activity in the feedstock sample. | 2013-12-19 |
20130337484 | METHOD FOR DETECTING A WOUND INFECTION - The present invention relates to a method for detecting a wound infection comprising the steps of: contacting a sample obtained from a wound with at least two substrates for at least two enzymes selected from the group consisting of lysozyme, elastase, cathepsin G and myeloperoxidase, and detecting a wound infection when a conversion of the at least two substrates with said at least two enzymes are determined. | 2013-12-19 |
20130337485 | ENZYMATIC SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENT AND INTERMEDIATES THEREOF - The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermediate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or intermediate thereof. | 2013-12-19 |
20130337486 | MICROFLUIDIC DEVICE FOR HIGH-THROUGHPUT CELLULAR GRADIENT AND DOSE RESPONSE STUDIES - The ability to form and maintain gradients is essential for the study of response of cells to various stimuli. The invention includes devices and methods for the high-throughput, reproducible formation of gradients for the study of living cells. The invention includes microfluidics device with a lest chamber having a depth flanked by flow-through channels having a deeper depth. Flow of two different fluids through the flow-through channels results in the creation of a gradient by diffusion across the test chamber having essentially no flow. | 2013-12-19 |
20130337487 | IN VITRO EMBRYO BLASTOCYST PREDICTION METHODS - Methods, compositions and kits for determining the likelihood of reaching the blastocyst stage for one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans. | 2013-12-19 |
20130337488 | Method and System for Measuring the Pharmacokinetics of Liposomal Curcumin and its Metabolite Tetrahydrocurcumin - The present invention includes a stabilized curcumin composition. The composition includes a curcumin composition and a phosphate composition, wherein the phosphate composition is non-buffering and is provided in an amount sufficient to stabilize and/or prevent the degradation of curcumin and/or a curcuminoid in a biological sample. | 2013-12-19 |
20130337489 | Method for Improved Detection of Microorganisms and the Like - A method is provided of applying a test sample to a fibrous pad containing growth media which uses unaccelerated dispersion and deposition of the microorganism. | 2013-12-19 |
20130337490 | SPOILAGE DETECTION USING ELECTROMAGNETIC SIGNAL AND MATHEMATICAL MODELING - The present disclosure provides a system for inspecting a package ( | 2013-12-19 |
20130337491 | System and Method of Assessing a Wellbore Servicing Fluid or a Component Thereof - A wellbore servicing fluid assessment method comprising introducing test organisms into a first section of a first tub, allowing organisms less than a first size to pass into a second section of the first tub, allowing organisms less than the first size to flow into a first section of a second tub, allowing organisms less than a second size to pass into a second section of the second tub, allowing organisms less than the second size to flow into a first section of a third tub, allowing organisms less than a third size to pass into a second section of the third tub, selecting test organisms of a desired testing size, dividing the selected test organisms into a control group and test group, subjecting the test group to the wellbore servicing fluid or a component, and assessing the acceptability of the wellbore servicing fluid or component. | 2013-12-19 |
20130337492 | METHOD AND SYSTEM FOR REAL-TIME, NON-INVASIVE MONITORING OF A BIOLOGICAL MATERIAL IN A SEALED CONTAINER - A biological material such as platelets is sealed inside a container with a dead space to accommodate a metabolic gas. The concentration of the gas in the dead space is monitored while the container remains sealed. In some embodiments, the container is permeable to the gas. In other embodiments, the biological material is the only growth medium in the container. The disposal of the biological material is in accordance with the monitored gas concentration. Preferably, the gas concentration is measured spectroscopically. A container for a biological material includes a main body that retains the biological material but that is permeable to a gas and a reservoir in fluid communication with the main body that is transparent to an optical wavelength that is absorbed by the gas. | 2013-12-19 |
20130337493 | QUALITY CONTRL DEVICES AND METHODS FOR RADIOPHARMACEUTICALS - A quality control (“QC”) system for PET or SPECT radiopharmaceuticals is disclosed that contains a disposable, no-leakage, self-contained QC cassette, which interfaces with the QC system. The QC system may include a shield that substantially surrounds the cassette such that the area and the cassette are both shielded. The QC cassette may contain shielding also. The QC cassette contains components for conducting one or more QC tests. These components include sensor and devices for performing various QC tests on radiopharmaceuticals. The QC system may contain a number of sub-systems and devices for supporting the QC tests. The QC system may produce a QC report containing the test results. | 2013-12-19 |
20130337494 | FLUORESCENT CYTOTOXIC COMPOUNDS SPECIFIC FOR THE CELLULAR POLYAMINE TRANSPORT SYSTEM - Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these compounds (3 and 4) had improved fluorescence properties over previously known anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy and fluorescence methods. These cytotoxic fluorescent agents may find use as molecular probes which traffic into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: λ405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are considered non-toxic to human cells (versus ultraviolet mediated excitations, λ<400 nm) and visible light lasers are less costly to purchase and operate than UV laser sources. | 2013-12-19 |
20130337495 | HIGH SPEED SPOILAGE DETECTION USING AN ELECTROMAGNETIC SIGNAL - The present disclosure provides a system for inspecting cases of packages having a substance subject to spoilage. An electromagnetic signal (e.g., a terahertz frequency signal) is directed to each package in a case, and an attenuated signal is received and sampled to generate a set of data points corresponding to each package. A peak within each set of data points is detected, and the data points are shifted with respect to time to align the detected peaks with a predetermined time. The sets of shifted data points are compared to a mathematical model to determine whether the substance in the package is spoiled, and a labeling system marks cases containing spoiled substance. | 2013-12-19 |