51st week of 2009 patent applcation highlights part 39 |
Patent application number | Title | Published |
20090311623 | PHOTOLITHOGRAPHY - The invention relates to a method of photolithography comprising the steps of: providing a substrate and forming a layer of a photoresist ( | 2009-12-17 |
20090311624 | RESIST UNDERLAYER FILM FORMING COMPOSITION CONTAINING LIQUID ADDITIVE - To provide a resist underlayer film forming composition for lithography that is used in a lithography process for production of a semiconductor device. There is provided a resist underlayer film forming composition used in a lithography process for production of a semiconductor device, comprising a resin (A), a liquid additive (B) and a solvent (C). The liquid additive (B) may be an aliphatic polyether compound. The liquid additive (B) may be a polyether polyol, polyglycidyl ether or a combination thereof. Further, there is provided a method of manufacturing a semiconductor device, including the steps of forming a resist underlayer film by applying the resist underlayer film forming composition on a semiconductor substrate and by calcining the composition; forming a photoresist layer on the underlayer film; exposing the semiconductor substrate coated with the resist underlayer film and the photoresist layer to light; and developing the photoresist layer after the exposure to light. | 2009-12-17 |
20090311625 | Method for forming photoresist pattern and photoresist laminate - A method for forming a photoresist pattern involves the steps of: depositing a photoresist film on a substrate, the photoresist film containing an acid-generating agent capable of generating an acid upon exposure to light; overlaying an antireflective film over the photoresist film, the antireflective film containing a fluorine-based acidic compound; selectively exposing the photoresist; and developing the photoresist. The novel method is characterized in that the acid-generating agent and the fluorine-based acidic compound are selected so that the acid that the acid-generating agent generates in the photoresist film upon exposure to light has a higher acidity than the fluorine-based acidic compound in the antireflective film. | 2009-12-17 |
20090311626 | RADIATION-SENSITIVE COMPOSITIONS AND ELEMENTS WITH SOLVENT RESISTANT POLY(VINYL ACETAL)S - A radiation-sensitive composition can be used to prepare positive-working imageable elements having improved solvent resistance and is useful for making lithographic printing plates. The composition includes an alkaline soluble polymeric binder that is a specific poly(vinyl acetal) that exhibits improved resistance to press chemicals, and a radiation absorbing compound. | 2009-12-17 |
20090311627 | Resist composition for immersion exposure and method of forming resist pattern using the same - A resist composition for immersion exposure, including a base component (A) that exhibits changed solubility in an alkali developing solution under action of acid, an acid generator component (B) that generates acid upon exposure, and a fluorine-containing compound (C) represented by general formula (c-1) (in formula (c-1), R | 2009-12-17 |
20090311628 | METHOD FOR ETCHING AN ULTRA THIN FILM - A method for etching an ultra thin film is provided which includes providing a substrate having the ultra thin film formed thereon, patterning a photosensitive layer formed over the ultra thin film, etching the ultra thin film using the patterned photosensitive layer, and removing the patterned photosensitive layer. The etching process includes utilizing an etch material with a diffusion resistant carrier such that the etch material is prevented from diffusing to a region underneath the photosensitive layer and removing portions of the ultra thin film underneath the photosensitive layer. | 2009-12-17 |
20090311629 | METHOD FOR MANUFACTURING ROLLER MOLD - A method for manufacturing a roller mold is described, including the following steps. A body is provided, wherein the body is a cylinder. A photoresist layer is formed to completely cover a cambered surface of the body. A mold including a pattern structure including a convex portion and a concave portion is provided, and the convex portion and the concave portion are covered with a transferred pattern layer. The mold is pressed on the photoresist layer. The body is rolled to transfer the transferred pattern layer on the convex portion onto the photoresist layer. The mold is removed. An UV light exposure step is performed on an exposed portion of the photoresist layer to transfer a pattern of the transferred pattern layer to the photoresist layer. The exposed portion of the photoresist layer is removed to expose a portion of the cambered surface of the body. A structure layer is formed on the portion of the cambered surface and the transferred pattern layer. The photoresist layer, and the structure layer and the transferred pattern layer on the photoresist layer are removed. | 2009-12-17 |
20090311630 | PROCESS FOR PRODUCING OPTICAL COMPONENT - The present invention relates to a process for producing an optical component, the process including: disposing a transparent stamp tool on a substrate or an imaging element through a transparent ultraviolet-curable resin composition layer; and irradiating the resin composition layer with an ultraviolet ray through the transparent stamp tool to thereby cure the resin composition layer, in which a resin composition contained in the resin composition layer contains a thermosetting resin as a main component and a photo-acid generator, and the ultraviolet ray passing through the transparent stamp tool is an ultraviolet ray having a wavelength of 320 nm or more. | 2009-12-17 |
20090311631 | NEAR-FIELD EXPOSURE APPARATUS AND NEAR-FIELD EXPOSURE METHOD - A near-field exposure apparatus includes a near-field exposure mask, a mechanism to place a substrate to be exposed, opposed to the near-field exposure mask, a mechanism to perform relative alignment of the near-field exposure mask and the substrate to be exposed, a mechanism to closely contact the near-field exposure mask and the substrate to be exposed, with each other, a mechanism to project exposure light to the near-field exposure mask, and a soft X-ray irradiating device to remove static electricity charged in at least one of the near-field exposure mask and the substrate to be exposed. The soft X-ray irradiating device is disposed at a side of the near-field exposure mask remote from the substrate to be exposed. | 2009-12-17 |
20090311632 | DEVELOPING METHOD AND DEVELOPING APPARATUS - A developing method comprising a developing step in which, while a wafer horizontally held by a spin chuck is being rotated, the wafer is developed by supplying a developer onto a surface of the wafer, wherein provided before the developing step is a pre-wetting step in which, simultaneously with the developer being supplied from a first nozzle that is located on a position near a central part of the surface of the rotating wafer, a deionized water as a second liquid is supplied from a second nozzle that is located on a position nearer to an outer peripheral part of the wafer than the first nozzle, to thereby spread out the developer in the rotating direction of the wafer by a wall that is formed by the deionized water flowing the outer peripheral side of the wafer with the rotation of the wafer. Thus, a wetting property of a surface of a resist film formed on the wafer that is made hydrophobic can be improved, whereby a developer film can be efficiently formed and thus the developing process can be stabilized. | 2009-12-17 |
20090311633 | PATTERN FORMING METHOD - A pattern forming method includes a step of forming a photosensitive organic material layer by providing, on a substrate, a photosensitive organic material which is protected by a hydrophobic photodegradable group and is capable of generating a hydrophilic group selected from the group consisting of amino group, hydroxyl group, carboxyl group, and sulfo group by light irradiation; a step of selectively exposing the photosensitive organic material layer to light in a pattern to generate the hydrophilic group at an exposed portion; a step of providing a block polymer having a hydrophilic segment and a hydrophobic segment, on the photosensitive organic material layer after the exposure, to separate segments of the block polymer into the hydrophilic segment at a portion where the hydrophilic group generated by the exposure is present and the hydrophobic segment at a portion where the hydrophilic group is not present; and a step of removing one of the separated segments to form a pattern of the other segment. | 2009-12-17 |
20090311634 | METHOD OF DOUBLE PATTERNING USING SACRIFICIAL STRUCTURE - A method of patterning a thin film on a substrate is described. The method includes forming a sacrificial structure over the thin film, and forming a photo-resist layer over the sacrificial structure. The sacrificial structure has anti-reflective properties, comprises silicon and is capable of withstanding the photo-resist layer removal process and the stress induced during the spacer layer deposition. Thereafter, an image pattern is formed in one or both of the sacrificial structure or the photo-resist layer. A spacer layer is then conformally deposited over the pattern. The spacer layer is etched back to remove horizontal portions while substantially leaving vertical portions. The remaining photo-resist and/or sacrificial structure that is not overlaid with the etched-back spacer layer is removed leaving spacers that are utilized to transfer another pattern to the thin film. | 2009-12-17 |
20090311635 | DOUBLE EXPOSURE PATTERNING WITH CARBONACEOUS HARDMASK - Methods to pattern features in a substrate layer by exposing a photoresist layer more than once. In one embodiment, a single reticle may be exposed more than once with an overlay offset implemented between successive exposures to reduce the half pitch of the reticle. In particular embodiments, these methods may be employed to reduce the half pitch of the features printed with 65 nm generation lithography equipment to achieve 45 nm lithography generation CD and pitch performance. | 2009-12-17 |
20090311636 | EXPOSURE APPARATUS, DEVICE MANUFACTURING METHOD, AND APERTURE STOP MANUFACTURING METHOD - A projection exposure apparatus includes an aperture stop that includes a light attenuation part that is located between a light shielding part and an opening part, and has a transmittance larger than that of the light shielding part and smaller than that of the opening part. A width of the light attenuation part is set within a range from a wavefront splitting period of the wavefront splitting device or a value of Z×tan(arcsin(α))/2 to a length that is five times as long as the wavefront splitting period of the wavefront splitting device, where a is a numerical aperture on an exit side of the wavefront splitting device, and Z is a distance between the focal plane of the wavefront splitting device on the exit side and the aperture stop. | 2009-12-17 |
20090311637 | BLOCK COPOLYMER AND SUBSTRATE PROCESSING METHOD - A block copolymer that can form selectively a microphase-separated structure under exposure with an ultraviolet exposure device, and a substrate processing method by which a micropattern can be formed at a low cost on the substrate by using the block copolymer. The block copolymer has as a basic skeleton a hydrophobic block that has a repeating structure of a hydrophobic monomer and a hydrophilic block that has a repeating structure of a hydrophilic monomer having a hydrophilic functional group. At least some of the hydrophilic functional groups are covered with a hydrophobic protective group and the hydrophobic protective group, which covers the hydrophilic functional group, is dissociated from the hydrophilic functional group by light irradiation. The substrate processing method uses the block copolymer to form a micropattern on the substrate. | 2009-12-17 |
20090311638 | Burner and Method for Alternately Implementing Oxycombustion and Air Combustion - Fuel is combusted with an oxidizer and at least one mainly inert gas, where the mainly inert gas is injected in the form of a divergently swirled jet around the flame and a convergently swirled jet surrounding the divergently swirled jet. | 2009-12-17 |
20090311639 | Method for Heating a Charge - The invention relates to a method for heating a charge using a flame generated by a lance and/or a burner, characterized in that, in a first phase, the flame is directed towards the charge and in that, in a second phase, the flame is directed more or less parallel to the charge. | 2009-12-17 |
20090311640 | Heating Method - Hot products of combustion are provided beside an outer surface of a load to be heated, and are given a non-uniform temperature profile in a control direction extending across the outer surface of the load. The non-uniform temperature profile of the hot products of combustion is varied within a range that is predetermined relative to the distance that the outer surface of the load extends in the control direction, whereby the load can be given a predetermined temperature profile in the control direction. | 2009-12-17 |
20090311641 | Gas flame stabilization method and apparatus - A burner includes: a body defining an interior cavity; a burning surface located in the body and defining, at least in part, the interior cavity; a defusing surface located on an exterior portion of the body; ports on the body extending through the defusing and burning surfaces and configured to provide fluid communication between the interior cavity and ambient air outside the body; and an opening larger than at least one of the ports, the opening providing fluid communication between the interior cavity and a space outside of the body. A method of burning a gas and reducing acoustic feedback in a combustion device are also described. | 2009-12-17 |
20090311642 | Oxygen Control System For Oxygen Enhanced Combustion - A method of configuration of combustion process control. The method includes providing a combustion system having a plurality of burner elements, a plurality of gas injection points and a controller. The gas injection points are configured to provide a support gas. One or more tasks for operation of the combustion system are determined. A plurality of groupings of the gas injection points are determined for each of the one or more tasks. An individual ranking for each of the plurality of groupings is determined in response to the one or more tasks. A composite ranking of injection points in response to the individual rankings and the controller is configured to operate the plurality of gas injection points in response to the composite ranking. A combustion system and a method for operating a combustion system are also disclosed. | 2009-12-17 |
20090311643 | Catalytic combustion converter systems and catalysts - The pipe's inner surface is treated by electodeposited elements of a heterogeneous catalyst consisting of Platinum, Palladium and rhodium. There are air tubes that are fed by a low pressure high volume air blower, that is connected to an air regulator and to an air collector that diverts the air flow into two separate tubes that enter the burner pipe 180 degrees apart from each other, entering the burner pipe at a 45 degree angle ⅔ the distance from the mounting flange to the burner pipes end. The treated burner pipe is mounted to a burner by a flange or other means. When the burner is ignited and pipe reaches 1000° to 1200° F. the catalyst is activated and air is added until the optimum stoichiometric air-fuel ratio is reached, which is dependant on the fuel used and the content of unburned fuel in the burner. | 2009-12-17 |
20090311644 | SOLUTION FOR TREATING LIME MUD - A method for treating lime mud, in which method the lime mud is conveyed to a lime kiln, where fuel gas is used as fuel, which fuel gas is formed by a circulating fluidized bed gasifier. A calcium compound is used as bed material in the gasifier. In addition, the invention relates to the use of a calcium compound in a lime mud treatment plant, as well as to a lime mud treatment plant. | 2009-12-17 |
20090311645 | Dental appliance - Embodiments include dental appliances, dental appliance systems, and methods of making and using such appliances. In one embodiment, a dental appliance includes a shell having a number of cavities to receive one or more teeth, each cavity having an inner surface. Fewer than all cavities are scaled-up in size by a first selected percentage over one or more dimensions of a corresponding tooth surface to provide a uniform space between the cavity inner surface and the corresponding tooth surface. | 2009-12-17 |
20090311646 | Orthodontic corrective appliance, especially for correcting malpositioned molars - An orthodontic corrective appliance for correcting malpositioned molars, wherein one end of the appliance is mounted on a supporting device, and the other end is applied to the given molar with spring loading includes a pusher element which is guided axially in a sleeve and is acted upon by a compression spring, and the free end of the pusher element extends from the sleeve and is provided with a connecting piece which is applied to the supporting device. Several small tubes on the outer surface of the sleeve have inner bores that guide and support a spacer bar that extends parallel to the sleeve. The end of the spacer bar that points towards the connecting piece is supported on one of the tubes, and the end of the spacer bar that faces away from the connecting piece is supported on a transpalatal arch, a Gashgarion lock or similar element. | 2009-12-17 |
20090311647 | 3D PLANNING AND PREDICTION METHOD FOR OPTIMIZING FACIAL SKELETON SYMMETRY IN ORTHOGNATHIC SURGERY - The method comprises steps of making a plaster dental cast of a patient, reconstructing jaw image assembly models, performing registration between physical stone and image model, adjusting the plaster dental cast based on a x-ray cephalometric plan, tracking movements of the plaster dental cast, obtaining optimal symmetry planes of the upper and lower jaw image assemblies, determining whether a degree of overall symmetry is elevated, and making surgical occlusal splints for surgical guiding. With foregoing method, possible results of executing an orthognathic surgical plan can be predicted and the surgical plan can be considered more carefully to achieve both occlusion function and facial symmetry. | 2009-12-17 |
20090311648 | Medical suction apparatus - The invention relates to a medical suction device ( | 2009-12-17 |
20090311649 | Method and material kit for the production of tooth replacement parts - The process for producing tooth replacement parts is characterized in that curable tooth replacement material is introduced into a first mold of part of the human dentition, a positive model produced from a second mold is pressed into this material and the tooth replacement material remaining after the pressing-in is allowed to cure to form the tooth replacement part(s). | 2009-12-17 |
20090311650 | Method for the production of a ceramic molded part - A process for the preparation of a ceramic molded part from a suspension/dispersion with a solids content and a fluid content by depositing solids content at the periphery of a porous self-supporting support that is at least partially immersed in the suspension/dispersion and has the same shape as the molded part to be prepared, but with a reduced size, wherein:
| 2009-12-17 |
20090311651 | POLYETHER-BASED PREPARATIONS AND USE THEREOF - The invention relates to preparations based on polymerizable polyether materials and a fluidity improver and to the use thereof in producing dental materials, especially impression materials. | 2009-12-17 |
20090311652 | TAKING COVER IN A SIMULATED ENVIRONMENT - An approach is described for instructing a player character to automatically take cover in a region of a simulated environment without receiving express commands from a user. The approach determines whether the player character should take cover based on one or more factors. Such factors may include: the presence of an enemy-type character in the region; the presence of a nearby object in the region that can be used to seek cover; and a determination whether the player character's behavior is consistent with a decision to seek cover. | 2009-12-17 |
20090311653 | Test Preparation Method - A method for preparing for a test includes providing a test preparation device compatible with game boards having thereon several different game piece spaces among which student/test taker can move game tokens. Play is accomplished by one student/test taker rolling a die or dice and then moving his token the number of spaces indicated by the die or dice. The student/test taker is then asked a question from a problem card of the test area subject subset correlated with the landed on game token space (e.g., as indicated by the discernible identifier associated with the particular game space). If the student/test taker answers the question correctly, he is awarded a point or like reward, and then repeats his turn until he fails to answer a question correctly. Thereafter, the next student/test taker has his turn. The game continues until one student/test taker wins. Winning can be accomplished in a number of ways, e.g., by being the first student/test taker to answer a question from each test area subject subset correctly, by accumulating a target number of points, or by having the largest number of points after a designated time period (e.g., 30, 45, 60, 90, 120, or 180 minutes). | 2009-12-17 |
20090311654 | Multistage Automatic Coaching Methodology - A method and system of providing computer based life coaching comprising the steps of: providing an interface that allows a user to valuate their present level of happiness in a series of broadly defined areas of life; including money, leisure, love, physical environment, professional development, friends and family, health, and personal growth. Once levels of happiness are obtained in each of these areas, a chart is created to determine which areas are of lowest satisfaction and address them. The system then prompts a user to establish factors related to each area of happiness and evaluate those factors in terms of importance level. Subsequently, the user is prompted to select various changes related to the factors and areas. Once the changes are selected, a description of the user after the changes occur is generated and supplied to the user. | 2009-12-17 |
20090311655 | SURGICAL PROCEDURE CAPTURE, MODELLING, AND EDITING INTERACTIVE PLAYBACK - A system for generating surgical procedure training media draws upon the realistic data of an actual surgical procedure for realistic training without the risks. A 3D capturing component records three-dimensional model plus imaging data over time of a portion of a patient's body undergoing a surgical procedure. A spatial detection system detects an orientation of a surgical instrument relative to the patient's body during the surgical procedure. A modeling component creates a four-dimensional model (3D model+time) of the portion of the patient's body. Animation such as contingent events, trainee prompts, a virtual surgical instrument, etc., can be added to the model to expand upon the training potential. A user interface processes and edits training media for playback of the four-dimensional model including defining triggers responsive to a trainee simulated surgical inputs to pace sequencing of playback. An interactive player responds to pacing the playback of the editing training media or to a spatially detected simulated surgical instrument held by the student for direct tissue interaction. | 2009-12-17 |
20090311656 | STATE SPACE MODEL OF A HEART - A state space model (SSM), being a computer-calculated model, adapted to represent the pumping and controlling functions of a heart that have been determined by a heart cluster state machine simulating the heart, and optionally the circulatory system, of an individual. The state space model includes two groups of separate interacting state machines, the heart muscle cell state machines and the displacement pump state machines. | 2009-12-17 |
20090311657 | System and method for providing differentiated content based on skill level - A system and method is disclosed for providing differentiated content to a user comprising determining a skill level of the user, obtaining unmodified content, aligning the unmodified content to a set of content standards, modifying the aligned content in accordance with the user's skill level, providing the modified aligned content to the user, re-assessing the user's skill level based on a response from the user to the modified aligned content, and modifying new aligned content in accordance with the re-assessed user's skill level. | 2009-12-17 |
20090311658 | SYSTEM AND METHOD FOR COLLABORATIVE DEVELOPMENT OF ONLINE COURSES AND PROGRAMS OF STUDY - A system and method for developing a course requires a plurality of participants that collaborate over a network, for example, a social network. A database stores an initial framework that defines a sequence of learning units for creating a desired learning environment for students, those learning units made of specifically ordered content objects. The learning units are identified by corresponding learning unit identifiers. A plurality of workstations coupled to the network are used for entry of reviewer information by the participants using the learning environment created for the students. The reviewer information comprise one or more comments entered by one participant about a learning unit or content object and a rank entered by anther participant about the comment, with the rank being correlated with a defined ranking standard. A processor processes the rank according to a predefined criteria to produce a ranking result that is associated with a learning unit identifier. The ranking result is used for associating learning content to the learning unit identified by the learning unit identifier. | 2009-12-17 |
20090311659 | System and Method For Scoring Constructed Responses - A computerized system for scoring constructed responses to one or more prompts. The system receives a plurality of constructed responses in an electronic font-based format and separates the plurality of constructed responses into a first group of constructed responses that are scorable by the system and a second group of constructed responses that are not scorable by the system. The constructed responses in the first group are assigned scores based on predetermined rules, and the scores are sent to a score database. In a preferred embodiment, the first group includes constructed responses that do not answer the prompt and constructed responses that match pre-scored responses. The second group of constructed responses are sent by the system to a hand-scorer for manual scoring. | 2009-12-17 |
20090311660 | DEMONSTRATIVE METHODS FOR PAPER TOWEL PRODUCTS - Demonstrative methods for sanitary tissue products, for example paper towel products, and more particularly, methods for demonstrating wet pilling differences between two or more paper towel products and paper towel product packages and marketing articles that evidence wet pilling differences between paper towel products are provided. | 2009-12-17 |
20090311661 | DEMONSTRATIVE METHODS FOR TOILET TISSUE PRODUCTS - Demonstrative methods for sanitary tissue products, for example toilet tissue products, and more particularly, methods for demonstrating wet pilling differences between two or more toilet tissue products and toilet tissue product packages and marketing articles that evidence wet pilling differences between toilet tissue products are provided. | 2009-12-17 |
20090311662 | Method for Harvesting and Preparing Porcine Hearts for Use in a Cardiac Surgical Simulator - A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for training surgical personnel for performing beating heart surgery. | 2009-12-17 |
20090311663 | Organ Transplant Solutions and Method for Transplanting Organs - A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a balanced isotonic aqueous solution comprising sodium, potassium, calcium, magnesium and bicarbonate ions in a physiologically acceptable amount, together with an effective amount of a mutein of the C5 | 2009-12-17 |
20090311664 | Method for Detection of Cancer Cells Using Virus - The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that are replication-competent conditional to a cancer cell, in particular an oncolytic herpes virus, such as NV 1066 and a vaccinia virus, such as GLV-1h68. Provided are methods and kits for using these viruses that preferentially replicate in cancer cells and may also preferentially infect cancer cells for specific identification of such cancer cells, even when a cancer cell is present, for example, at a ratio of one infected cancer cell in a background often thousand non-cancer cells, thus further providing a reproducible and sensitive screening method for cancer detection, monitoring and prognosis. | 2009-12-17 |
20090311665 | Methods, compositions, and kits for collecting and detecting oligonucleotides - Methods, pharmaceutical compositions, and kits are provided which includes accurately sampling a RNA from a tissue of an animal and analyzing RNA in the tissue of the animal as an indicator of physiological state, infectious disease, neoplastic disease, autoimmune disease, inflammatory disease, cardiovascular disease, atherosclerotic disease, or neurological disease in the animal. A method is provided which includes administering at least one compound to an animal wherein the at least one compound is configured to prevent the cleavage of at least one tissue RNA by a ribonuclease. The method further includes collecting a sample of at least a portion of tissue from the animal. | 2009-12-17 |
20090311666 | MICROFLUIDIC DEVICE FOR CRYSTALLIZATION AND CRYSTALLOGRAPHIC ANALYSIS OF MOLECULES - The present invention relates to a microfluidic device comprising at least one crystallization chamber adapted for comprising a solution in which at least one compound is present according to a concentration gradient, and wherein the geometry of said crystallization chamber allows for convection phenomena to be limited. The invention also relates to the use of said device, in particular for crystallization by counter diffusion and to a crystallization method. | 2009-12-17 |
20090311667 | RAPID DIAGNOSIS METHOD SPECIFIC TO AVIAN INFLUENZA VIRUS - The present invention relates to a method for detecting an avian influenza virus by an immunological assay using an anti-influenza virus antibody being unreactive to human influenza type-A virus subtypes H1, H2 and H3 and a human influenza type-B virus and being reactive to plural subtypes of avian influenza viruses, and an immunochromatographic test tool for use in the method. According to the present invention, an avian influenza virus can be detected specifically, rapidly and in a simple manner, as distinguishing an avian influenza virus from a human influenza virus. | 2009-12-17 |
20090311668 | In situ detection of early stages and late stages HPV einfection - Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. The anti-HPV antibodies are used in performing immunological assays on clinical samples. Various immunological assays and kits for detecting HPV infection, cervical cancer, other HPV related cancers, early stage precancerous lesions as well as late stage cancer progression are also provided. | 2009-12-17 |
20090311669 | SIGNAL FOR PACKAGING OF INFLUENZA VIRUS VECTORS - The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and cells. | 2009-12-17 |
20090311670 | APPARATUS AND METHOD FOR MEASURING CONCENTRATION OF MOLECULES THROUGH A BARRIER - An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction (hereinafter “affinity”), i.e., the affinity between charged atoms and molecules that cause their chemical interactions and reactions, to infer, based on the behavior of molecules on one side of the barrier, the presence and concentration of corresponding molecules on the other side of the barrier. The invention is useful, by way of example and not limitation, in non-invasively measuring glucose levels of diabetic patients. | 2009-12-17 |
20090311671 | Diagnosis of risk of breast cancer - A diagnostic method is disclosed which can he used to predict the risk of cancer, in particular breast cancer. The method comprises: (i) isolating a sample of the patient's genome: and (ii) detecting the presence or expression of the gene comprised within the sequence identified herein as SEQ ID No. 1, wherein the presence or expression of the gene indicates the presence of or the risk of cancer. | 2009-12-17 |
20090311672 | Detection of amplicon contamination during pcr exhibiting two different annealing temperatures - A method to perform PCR reactions with one set of primers comprising sequence elements that are complementary to the target sequence and comprising sequence elements that server as tagging sequences. By conducting amplification reactions at different temperatures, the presence of contaminations arising from amplification products of previous reactions can be determined, improving reliability of the reaction and reducing the need for control reactions and reproduction of reactions. | 2009-12-17 |
20090311673 | NUCLEIC ACID AMPLIFICATION METHODS - The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for repeatedly operating the heat exchange component to subject the sample to thermal cycling, an excitation source for optically exciting the sample to cause the sample to fluoresce, a photodetector for detecting temperature-dependent fluorescence levels from the sample, and a processor configured to record and process emissions from the fluorescent dye. | 2009-12-17 |
20090311674 | Phosphate Biosensors and Methods of Using the Same - Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells. | 2009-12-17 |
20090311675 | Apparatus for Monitoring Thrombus Formation and Method of Mointoring Thrombus Formation - An apparatus for monitoring thrombus formation wherein anticoagulated blood is flown through a channel simulating a blood vessel while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation. This apparatus for monitoring thrombus formation comprises: a thrombus formation chamber in at least a part of which a thrombus formation inducer inducing thrombus formation is provided; an inlet tube which is connected to the thrombus formation chamber and through which blood is flown into the thrombus formation chamber; and a drug tube which is connected to the inlet tube and through which a drug releasing the anticoagulant treatment or a drug promoting blood coagulation is supplied. A method of monitoring thrombus formation which comprises flowing anticoagulated blood into a thrombus formation chamber, in at least a part of which a thrombus formation inducer inducing thrombus formation is provided, while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation. | 2009-12-17 |
20090311676 | Method for preparing primer used for determining the mutation in PDS gene related to large vestibular aqueduct syndrome in vitro and the use of the primer - The present invention relates to a method of preparing a primer used for determining the IVS7-2A→G site mutation involved in the large vestibular aqueduct syndrome. The method comprises the steps of: designing a primer pair which may introduce any base substitutive mutation in the region of 1-13 bases between upstream and downstream including the IVS7-2 mutation site (A→G) based upon the IVS7-2 A→G mutation site in the PDS gene, so as to obtain a new restriction site which may be used for distinguishing IVS7-2 wild type A site and mutant G site in the amplification products. The present invention further relates to the primers prepared according to this method, the kit or reagent or identical product comprising the primers, and a method for determining the IVS7-2A→G site mutation of large vestibular aqueduct syndrome with said primers in vitro. | 2009-12-17 |
20090311677 | Identification of contaminating bacteria in industrial ethanol fermentations - A method for determining the presence of a contaminating organism in a fermentation process includes initiating the fermentation process using a syngas and obtaining a first aliquot from the fermentation process. The method further includes subjecting said first aliquot to a polymerase chain reaction using at least one oligonucleotide primer capable of hybridizing to a target sequence of a genomic nucleic acid from a suspected contaminating organism, producing a first amplified product based on the polymerase chain reaction, separating the first amplified product based on size, and determining the presence of the suspected contaminating organism based on the first separated amplified product. | 2009-12-17 |
20090311678 | METHOD OF DISCRIMINATING AT LEAST TWO CELL POPULATIONS, AND APPLICATION - A subject of the invention is a method for discriminating between and counting at least two populations of biological elements carrying specific characteristics, optionally present in a sample. The invention allows the clear and unambiguous detection of at least three populations of biological elements by the use of only two detection means, which means that at least two populations of biological elements are detected by one and the same detection means. The invention can be carried out if three different probes are used, each recognizing and becoming fixed to one of the populations of biological elements to be detected, each of the probes being itself rendered detectable by a different marker, two of said markers having two emission spectra having at least one common part (overlapping emission spectra) and the third having an emission spectrum having essentially no part in common with the other two (non-overlapping spectrum). | 2009-12-17 |
20090311679 | TaqMan MGB probe useful for detecting the mitochondrial gene C1494T mutation associated with maternally inherited deafness and the use thereof - The present invention relates to a real time quantitative TaqMan MGB probe useful for detecting the mitochondrial gene C1494T mutation associated with maternally inherited deafness and the use thereof. The present invention design a Taqman mutant probe and a wild type MGB probe, and a pair of primers. A maternally inherited deafness associated with mitochondrial gene C1494T mutation can be diagnosed by the method of real time quantitative Taqman MGB probe. This method is characteristic of easily operating, fast, high specificity, high sensitivity, and the interpretation of the result is intuitionistic, accurate and reliable. It's suitable for large scale screen and preventive examination of mitochondrial gene C1494T mutation associated with maternally inherited deafness. | 2009-12-17 |
20090311680 | Method for Identifying Useful Proteins of Brewery Yeast - The invention relates to a method for identifying a useful protein of brewery yeast. More specifically, the invention relates to (a) cultivating yeast under a predetermined cultivation condition; (b) extracting a protein sample from the cultivation product of the yeast; (c) separating the protein sample by a protein separation means, selecting a target peak or spot, and recovering the target protein or a fragment thereof contained in the peak or spot; (d) determining the amino acid sequence of the target protein; (e) comparing the amino acid sequence determined in step (d) with the amino acid sequence determined in advance based on all or a part of genome sequence information of bottom fermenting yeast; (f) identifying the target protein and the gene encoding the target protein based on the results of comparison; and (g) analyzing functions of the identified gene to identify characters given to the yeast by the gene. | 2009-12-17 |
20090311681 | PHARMACODIAGNOSTIC TEST TARGETING ONCOLOGY AND NEURODEGENERATION - A first objective of the present invention is to demonstrate a method for the detection and prognosis of cancer and of its metastatic potential. Preferably, the cancer is selected from breast cancer, bladder cancer, ovarian cancer, lung cancer, skin cancer, prostate cancer, colon cancer, liver cancer, a sarcoma and a leukaemia, without being limited thereto. One aspect of the present invention consists of the use of the LIV21 complex as a prognostic indicator for cancer and in the therapeutic monitoring thereof. The LIV21 complex is defined in terms of the extract of proteins and peptides studied by Maldi and ESI MS/MS or Maldi Tof/Tof mass spectrometry. Said extract was obtained by attachment of the LIV21 complex to one of these LIV21 polyclonal antibodies. The LIV21 complex is also defined in terms of its overall mass spectrometry profile (FIG. | 2009-12-17 |
20090311682 | COMBINATION OF AVIAN CELL MARKERS - The present invention relates to a novel combination of avian cell markers which make it possible to characterize the said cells according to their phenotype, whether they are StX cells, stem cells or germ cells. The present invention also relates to a method for characterizing avian cells with the said markers, and to a method for culturing avian cells, in which the cells are characterized by the method according to the invention. | 2009-12-17 |
20090311683 | COMPOSITIONS FOR THE USE IN IDENTIFICATION OF FUNGI - The present invention provides compositions, kits and methods for rapid identification and quantification of fungi by molecular mass and base composition analysis. | 2009-12-17 |
20090311684 | ENHANCED FC RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH RHEUMATOID ARTHRITIS - A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of TNFSF-3, TNFSF-4, TNFSF-7, TNFSF-11, or TNFSF-14 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed. | 2009-12-17 |
20090311685 | NMU-GHSR1b/NTSR1 oncogenic signaling pathway as a therapeutic target for lung cancer - The present invention relates to a method of and a kit for assessing the prognosis of lung cancer by detecting the expression level of the neuromedin U (NMU) gene in a patient-derived biological sample. The method and kit are particularly preferred for assessing the prognosis of non-small cell lung cancer (NSCLC). Furthermore, the present invention relates to a method of screening for a therapeutic agent for cancer, in particular, lung cancer, by detecting compounds that inhibit the binding of the NMU protein with the heterodimer of growth hormone secretagogue receptor 1 | 2009-12-17 |
20090311686 | METHOD RELATING TO SWEETNESS ENHANCEMENT - We have discovered a method to enhance sweetness comprising the use of a sweetener at a sub- to near-threshold concentration which is used in combination with a suprathreshold concentration of another sweetener. The sweetener used at the near-threshold concentration is selected based on its likely binding site in the human sweet taste receptor. The invention relates to the identification of agents that can modulate the taste response in humans (such as sweet taste enhancers) through assays based on a novel sweet receptor protein, heterologous expression systems containing nucleic acid constructs forming said novel sweet receptor protein, and the use of the novel sweet receptor protein in screening. | 2009-12-17 |
20090311687 | MICROORGANISMS DETECTION AND ENUMERATION METHOD - A method for detecting and enumerating viable microorganisms, preferably selected from the group consisting of | 2009-12-17 |
20090311688 | Novel Labeled oligonucleotide - The present invention relates to a labeled oligonucleotide comprising a first nucleotide segment and a second nucleotide segment, complementary to a target sequence, characterized in that it comprises a fluorophore, a quencher and at least one alpha-anomeric nucleoside. The invention also relates to the use of such an oligonucleotide and also to a process using such an oligonucleotide. | 2009-12-17 |
20090311689 | Genomic marker for tenderness meat - The invention concerns the use of a genomic marker comprising a nucleotide sequence corresponding to all or part of the nucleotide sequence SEQ ID No. 1, or to all or a part of an allele of the nucleotide sequence SEQ ID No. 1 and associated with the phenotype relating to the tenderness of the meat from bovines, for the implementation of any identification method for the quantification of DNAJA1 expression level with the aim of selecting and/or sorting ruminant animals of the bovine type which produce tender meat and/or for the implementation of an identification method of tender meats at the moment of slaughter by direct sampling from the carcass. | 2009-12-17 |
20090311690 | VECTOR FOR SCREENING ANTIBODY - It is an object of the present invention to provide a simple and efficient means capable of evaluating the VH/VL interaction without expressing/purifying VH and VL. The present invention provides a recombinant vector comprising: (i) a nucleotide sequence which can express a hetero-assembly composed of two types of fusion proteins wherein heavy chain variable region (VH) and light chain variable region (VL) of antibody are respectively fused with mutually associable first polypeptide and second polypeptide, by means of secretion, or in a form of a fusion protein tethered to a phage coat protein; and (ii) a restriction enzyme recognition sequence at two sites within, or in a vicinity of, a nucleotide sequence encoding said first polypeptide or second polypeptide. | 2009-12-17 |
20090311691 | Nucleic acid analysis by random mixtures of non-overlapping fragments - The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such final tier is from a particular aliquot, which, in turn, is from a particular aliquot of a prior tier, and so on. For every fragment of an aliquot in the final tier, the aliquots from which it was derived at every prior tier is known, or can be discerned. Thus, identical sequences from overlapping fragments from different aliquots can be distinguished and grouped as being derived from the same or different fragments from prior tiers. When the fragments in the final tier are sequenced, overlapping sequence regions of fragments in different aliquots are used to register the fragments so that non-overlapping regions are ordered. In one aspect, this process is carried out in a hierarchical fashion until the one or more target polynucleotides are characterized, e.g. by their nucleic acid sequences, or by an ordering of sequence segments, or by an ordering of single nucleotide polymorphisms (SNPs), or the like. | 2009-12-17 |
20090311692 | ISOLATION OF NUCLEIC ACID FROM MOUTH EPITHELIAL CELLS - The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants. | 2009-12-17 |
20090311693 | METHOD FOR THE IN VITRO SCREENING OF ANTI-CANCER COMPOUNDS THAT INHIBITS SK3 ACTIVITY, AND SAID ANTI-CANCER COMPOUNDS - The present invention relates to methods for the in vitro screening of an anti-metastatic compound that inhibits activity, methods for determining in vitro the presence or absence of a metastatic cancer in a subject by quantifying SK3 activity, methods for the in vitro assessment of the progression of the metastatic property of a cancer by quantifying SK3. | 2009-12-17 |
20090311694 | Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases - There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R. | 2009-12-17 |
20090311695 | Method - In one aspect, there is described a method for determining the effect of a genetic variation or mutation on the integrity of an RNA transcript comprising the steps of: (a) providing a nucleic acid construct comprising two different reporters separated by an in frame splicing unit, wherein said splicing unit comprises at least two exons separated by at least one intron and wherein at least one exon (eg. the exon downstream of said intron) comprises the genetic variation; (b) transfecting said construct into a cell and/or generating a stable cell line; (c) culturing said cell; and (d) determining the effect of said genetic variation on the integrity of the RNA transcript, wherein a difference in reporter activity in comparison to a cell comprising the nucleic acid construct without the genetic variation is indicative that said genetic variation affects the integrity of the RNA transcript. Assays—such as high throughput assays—are also described for identifying agents (nucleic acids, peptides and small molecules) that modulate the integrity of the RNA transcript and/or are involved in modulating RNA metabolism. | 2009-12-17 |
20090311696 | POLYMORPHISMS IN THE HUMAN CYP2B6 GENE AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the CYP2B6 genes. In particular, polynucleotides of molecular variant CYP2B6 genes which, for example, are associated with insufficient metabolization and/or sensitively of drugs, and vectors comprising such polynucleotides are provided. Furthermore, host cells comprising such polynucleotides or vectors and their use for the production of variant CYP2B6 proteins are described. In addition, variant CYP2B6 proteins and antibodies specifically recognizing such proteins as well as transgenic non-human animals comprising the above-described polynucleotide or vectors are provided. Described are also methods for identifying and obtaining inhibitors for therapy of disorders related to the malfunction of the CYP2B6 gene as well as methods of diagnosing the status of such disorders. Pharmaceutical and diagnostic compositions useful for diagnosing and treating various diseases with drugs that are substrates, inhibitors or modulators of the CYP2B6 gene product are described as well. | 2009-12-17 |
20090311697 | METHODS FOR SCREENING FOR GENETIC PREDISPOSITION TO TYPE I DIABETES - A method of genetically screening large numbers of individuals to identify those individuals requiring follow-up testing for active Type I diabetes (T1D) is provided. The method includes obtaining a nucleic-acid containing biological sample from each individual and testing for the presence of specific combinations of HLA II alleles in the sample. | 2009-12-17 |
20090311698 | DIAGNOSTIC ASSAY - Certain embodiments of the present invention relate to methods for detecting DNA or RNA (including, but not limited to, mRNA). | 2009-12-17 |
20090311699 | METHOD OF SURFACE PLASMON RESONANCE (SPR) TO DETECT GENOMIC ABERRATIONS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA - This invention discloses using SPR technology to detect CLL related genomic aberrations in peripheral blood samples. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of CLL related DNA markers used for the detection of genomic aberrations for patients with chronic lymphocytic leukemia (CLL) is also disclosed. | 2009-12-17 |
20090311700 | Methods for Breast Cancer Prognosis - The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer in untreated breast cancer patients. More specific, the present invention relates to the prognosis of breast cancer based on measurements of the expression levels of marker genes in tumor samples of breast cancer patients. Marker genes are disclosed which allow for an accurate prognosis of breast cancer in patients having node negative, fast proliferating breast cancer. | 2009-12-17 |
20090311701 | Organ-specific gene, method for identifying the same and use thereof - The present invention provides a method of extracting an organ- or tissue-specific highly expressed gene, including: | 2009-12-17 |
20090311702 | TESTS TO PREDICT RESPONSIVENESS OF CANCER PATIENTS TO CHEMOTHERAPY TREATMENT OPTIONS - The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide. | 2009-12-17 |
20090311703 | METHODS FOR IDENTIFYING FACTORS FOR DIFFERENTIATING DEFINITIVE ENDODERM - Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube. | 2009-12-17 |
20090311704 | COMPOSITIONS AND METHODS FOR DIAGNOSIS OF AUTOPHAGIC VACUOLAR MYOPATHY - Transmembrane V-ATPase proton pump complexes regulate pH of extracellular space or intracellular compartments of cells. V-ATPase complexes are ubiquitous in cells across species. A human orthologue of yeast vma21, LOC203547 (VMA21), is likely involved in the assembly of the V-ATPase. Hypomorphic mutations of VMA21 are identified from XMEA patients. Methods to diagnose and/or distinguish between different forms of vacuolar or vacuolated myopathy in an individual or patient are provided based either on the sequence of the VMA21 gene and/or the level and/or activity of the V-ATPase complex. Compositions of the present invention may comprise DNA, RNA, or protein molecules corresponding to all or a portion of VMA21 and including one or more of the mutations in VMA21 identified. Cultured cells or cell lines having one or more mutations in the VMA21 gene derived from patients having a form of vacuolar or vacuolated myopathy are provided. | 2009-12-17 |
20090311705 | METHOD OF DETERMINING EFFICIENCY OF OVUM COLLECTION IN BOVINE - The novel means by which an efficiency of ovum collection can be easily determined in bovine at gene level is disclosed. The present inventors performed the genomic linkage analysis using bovine populations with high and low efficiency of ovum collection and to identify GRIA1 gene, which encodes an ion channel protein, as a factor deeply related to an efficiency of ovum collection. Bovines having a mutation (e.g. the amino acid substitution of aa306) in GRIA1 produce significantly fewer ova on superovulatory treatment than those not having the mutation. Therefore, the efficiency of ovum collection can be determined based on the existence of a mutation in GRIA1 gene. | 2009-12-17 |
20090311706 | QUANTITATIVE ANALYSIS OF IN VIVO MUTATION AT THE PIG-A LOCUS - The invention relates to methods and kits for the quantitative analysis of in vivo mutation frequencies of the Pig-A gene in individuals exposed to a genotoxicant, particularly using peripheral blood samples of vertebrates. | 2009-12-17 |
20090311707 | O-GLYCANS AS DIAGNOSTIC MARKERS FOR INFLAMMATORY BOWEL DISEASE - The present invention provides diagnostic methods for inflammatory bowel disorders (e.g., Crohn's disease or ulcerative colitis) comprising assessing expression, structure and/or function of O-glycans in a sample from a subject, as well as antibodies to such molecules. | 2009-12-17 |
20090311708 | METHOD OF DETERMINING A CHEMOTHERAPEUTIC REGIMEN BASED ON ERCC1 AND TS EXPRESSION - The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and prognosticate the probable resistance of a patient's tumor to treatment with 5-FU and oxaliplatin-based therapies by examination of the amount of TS and/or ERCC1 mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level for those genes. More specifically, the invention provides to oligonucleotide primer pairs ERCC1 and TS and methods comprising their use for detecting levels of ERCC1 and TS mRNA, respectively. | 2009-12-17 |
20090311709 | Compositions, Methods, and Kits for (MIS)Ligating Oligonucleotides - Methods, reagents, and kits for (mis)ligating oligonucleotide probes or for identifying at least one target nucleotide are disclosed. One can enhance the generation of misligation product using a ligase under reaction conditions and with reagents where that particular ligase is prone to misligation. Alternatively, one can decrease or avoid generating misligation products using a particular ligase under reaction conditions and using reagents where that ligase is at least less prone to misligation. In certain embodiments, the recombinant ligase from | 2009-12-17 |
20090311710 | MUTAGENESIS METHODS USING RIBAVIRIN AND/OR RNA REPLICASES - The use of RNA-replicases for introducing mutations into and selecting for improved RNA molecules is described. The use of ribavirin, or a derivative/analogue thereof, in methods for introducing one or more mutations during replication or transcription of a target nucleic acid molecule is also described. These methods can be used to screen for nucleic acids, or proteins encoded thereby, with altered or new activity. Also provided are kits comprising ribavirin, or a derivative/analogue thereof, for use in mutagenesis procedures. | 2009-12-17 |
20090311711 | CRH and POMC Effects on Animal Growth - The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the knowledge of their CRH, POMC and MC4R genotypes. The predictive value comes from the discovery that certain single nucleotide polymorphisms (SNPs) in these genes are linked to higher growth rate phenotypes. Specifically, the phenotypes that correlated with specific SNP's are end-of-test rib-eye area, adjusted weaning weight, average daily gain, shipping weight and hot carcass weight. The invention also provides novel kits that can be used in making the determination of these genotypes. The invention further provides for methods of screening bovines to predict which animals will have higher growth rate, allowing producers to selectively breed and manage animus based on desired characteristics, thereby maximizing productivity and profitability in commercial meat production operations. | 2009-12-17 |
20090311712 | METHOD OF SCREENING MULTIPLE SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH SUSCEPTIBILITY TO SPECIFIC DISEASE OR DRUG RESPONSE - Provided is a method of screening multiple single nucleotide polymorphisms (SNPs) having significance with a case group, the method comprising: selecting one or more SNPs from nucleic acid sequences of the case group and a control group; generating all combinable genotype patterns of multiple SNPs comprised of two or more of the selected SNPs; determining frequencies of the genotype patterns from the case group and the control group; and determining and choosing genotype patterns having statistical significance with the case group using the frequencies. According to the method of screening multiple SNPs, multiple SNPs associated with a specific disease or drug can be effectively selected from the entire genome of an individual. Methods of identifying susceptibility of an individual to development of Type II diabetes are also disclosed. | 2009-12-17 |
20090311713 | Method of Detecting an Analyte - The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, a method of detecting an analyte is provided and includes providing in a detection window a droplet including a signal-producing substance indicative of the presence and/or quantity of an analyte and one or more magnetically responsive beads which may interfere with signal produced by the signal producing substance. The method further includes using a magnetic field for magnetically removing the magnetically responsive beads from the detection window and/or magnetically restricting the magnetically responsive beads from entering the detection window while transporting and/or retaining the droplet in the detection window. The method additionally includes detecting a signal produced by the signal-producing substance. | 2009-12-17 |
20090311714 | Methods for the Screening of Antibacterial Substances - The present invention concerns a method for the screening of antibacterial substances comprising a step of determining the ability of a candidate substance to inhibit the activity of a purified enzyme selected from the group consisting of: (i) a D-aspartate ligase comprising a polypeptide having an amino acid sequence possessing at least 50% amino acid identity with an amino acid sequence selected from the group consisting of SEQ ID No 1 to SEQ ID No 10, or a biologically active fragment thereof; and (ii) a L,D-transpeptidase comprising a polypeptide having an amino acid sequence possessing at least 50% amino acid identity with the amino acid sequence of SEQ ID No 11, or a biologically active fragment thereof. | 2009-12-17 |
20090311715 | IDENTIFYING CORONARY OR SOFT TISSUE CALCIFICATION - This document relates to methods and materials involved in identifying calcification (e.g., coronary calcification or soft tissue calcification) in mammals and assessing thrombotic risk in mammals. For example, methods and materials involved in using microvesicles as a marker to determine whether or not a mammal (e.g., a human) has calcification or an elevated risk of thrombosis are provided. In addition, methods and materials for determining the amount and source of microvesicles are provided. | 2009-12-17 |
20090311716 | METHODS TO TREAT OR PREVENT HORMONE-RESISTANT PROSTATE CANCER USING siRNA SPECIFIC FOR PROTOCADHERIN-PC, OR OTHER INHIBITORS OF PROTOCADHERIN-PC EXPRESSION OR ACTIVITY - The invention is directed to compounds and methods for treating or preventing hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity, including antisense oligonucleotides and antibodies. The invention also provides for the use of protocadherin-PC as an in vivo prostate cancer biomarker, and includes a kit for detecting prostate cancer in biological samples. Also covered by the invention is a transgenic non-human mammal engineered to overexpress protocadherin-PC specifically in the prostate. | 2009-12-17 |
20090311717 | MICROFLUIDIC CHIP DESIGN COMPRISING CAPILLARIES - The invention provides a microfluidic device wherein capillaries are connected to the microfluidic device by a deformable penetrable substance. | 2009-12-17 |
20090311718 | DEGRADED AGONIST ANTIBODY - The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases. | 2009-12-17 |
20090311719 | IN VITRO METHOD FOR DIAGNOSING NEURODEGENERATIVE DISEASES - Disclosed is an in vitro method for the detection, for the determination of the severity and for the assessment of the progress and prediction of neurodegenerative diseases, in which the presence and/or concentration of carbamoyl phosphate synthetase 1 (CPS 1) is determined in a biological fluid of a patient who suffers from a neurodegenerative disease or is suspected of suffering from such a disease, and conclusions about the presence, progression, severity or success of a treatment of the neurodegenerative disease are drawn on the basis of the determined presence and/or concentration of CPS 1 or the non-detectability of a CPS 1 immune reactivity. | 2009-12-17 |
20090311720 | METHODS OF MODULATING AND IDENTIFYING AGENTS THAT MODULATE INTRACELLULAR CALCIUM - Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium. | 2009-12-17 |
20090311721 | ASBESTOS EXPOSURE, PLEURAL MESOTHELIOMA, AND SERUM OSTEOPONTIN LEVELS - The present invention provides diagnostic methods based on the serum levels of osteopontin. | 2009-12-17 |
20090311722 | Truncated recombinant major outer membrane protein antigen (R56) of orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines - A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, | 2009-12-17 |