50th week of 2015 patent applcation highlights part 10 |
Patent application number | Title | Published |
20150352215 | PLANTS AS FUNCTIONAL MICRORNA AND/OR FUNCTIONAL SIRNA CARRIERS, PREPARATION METHODS AND USES THEREOF - The invention relates to plants as functional microRNA and/or functional siRNA vehicles, the preparation methods and uses thereof. In particular, disclosed in the present invention are plants or edible portions or extracts thereof as functional microRNA and/or functional siRNA vehicles and uses thereof. Also disclosed is a method for carrying the functional microRNA and/or functional siRNA, comprising the step of orally administering the plants or edible portions or extracts thereof to a subject in need thereof, wherein the plants or edible portions thereof express and carry the functional microRNA and/or functional siRNA vehicles, and the extracts contain the functional microRNA and/or functional siRNA. | 2015-12-10 |
20150352216 | CONJUGATE OF A FRAGMENT OF A CELLULAR WALL OF A BACTERIUM AND A MUCOPOLYSACCHARIDIC CARRIER, AND USES IN MEDICINE THEREOF - The present invention relates in one aspect to a conjugate of a mucopolysaccharide or mucopolysaccharidic fraction and a cellular wall fragment of a bacterium belonging to the | 2015-12-10 |
20150352217 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties - There is disclosed a compound, a pharmaceutical composition and a method of treatment using a pharmaceutical composition comprising a tethering moiety that is capable of binding to a macrophage migration inhibitory factor (MIF) polypeptide, optionally linked to a linker moiety and further covalently bound to a drug moiety or imaging agent. More specifically, there is disclosed a genus of affinity-tethering moieties covalently bound to a drug moiety or imaging agent either directly or optionally via a linker moiety to covalently link the tethering moiety to a drug moiety. Without being bound by theory, the disclosed pharmaceutical compounds are targeted to cancer cells or immune cells via an affinity-tethering moiety that hitch-hikes to or into its target cell while bound to endogenous MIF. | 2015-12-10 |
20150352218 | HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM - 1H-Imidazo[4,5-c]quinolin-4-amines substituted at the 1-position with a substituent bearing a hydrazinobenzamide or hydrazinonicotinamide, a salt thereof, or a protected hydrazinobenzamide or hydrazinonicotinamide and conjugates made from such compounds are disclosed. Pharmaceutical compositions containing the compound or the conjugate, methods of making a conjugate, and methods of use of the compounds or conjugates as immunomodulators for inducing cytokine biosynthesis in an animal and for vaccinating an animal are also disclosed. | 2015-12-10 |
20150352219 | CONJUGATE COMPOUNDS - The invention relates to sphingoglycolipid analogues and peptide derivatives thereof, which are useful in treating or preventing diseases or such as those relating to infection, atopic disorders, autoimmune diseases or cancer. | 2015-12-10 |
20150352220 | SELF-ASSEMBLING ULTRASHORT PEPTIDES MODIFIED WITH BIOACTIVE AGENTS BY CLICK CHEMISTRY - The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels. | 2015-12-10 |
20150352221 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 2015-12-10 |
20150352222 | HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF - The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker. | 2015-12-10 |
20150352223 | CROSS-LINKERS AND THEIR USES - Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same. | 2015-12-10 |
20150352224 | ANTIBODY-DRUG CONJUGATE PRODUCED BY BINDING THROUGH LINKER HAVING HYDROPHILIC STRUCTURE - As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L | 2015-12-10 |
20150352225 | Anti-Her2 Antibody-Maytansine Conjugates and Methods of Use Thereof - The present disclosure provides anti-HER2 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same. | 2015-12-10 |
20150352226 | SUSTAINED RELEASE POLOXAMER CONTAINING PHARMACEUTICAL COMPOSITIONS - A thermo-reversible thermoplastic pharmaceutical composition, comprising a botulinum toxin and a biocompatible poloxamer which provides thermoreversibility to the composition and additionally stabilizes the botulinum toxin, is described. The pharmaceutical composition can be administered to a patient as a liquid, and gels after administration into a sustained release drug delivery system from which the biologically active botulinum toxin is released over a multi-day period thereby localizing the drug as a depot and controlling release to enhance the therapeutic effect per dose. | 2015-12-10 |
20150352227 | METHOD FOR ACCUMULATING TITANIUM OXIDE COMPOSITE PARTICLES INTO A CANCER TISSUE - A method for accumulating titanium oxide composite particles into a cancer tissue, which comprises the steps of—providing titanium oxide composite particles which comprise: titanium oxide particles; and a nonionic hydrophilic polymer bound to a surface of the titanium oxide particles through at least one functional group selected from carboxyl group, amino group, diol group, salicylic acid group, and phosphoric acid group, and—administrating the composite particles to a patient thereby the composite particles are accumulated in the cancer tissue. | 2015-12-10 |
20150352228 | METHODS AND COMPOSITIONS FOR ENHANCING TRANSDUCTION EFFICIENCY OF RETROVIRAL VECTORS - The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as a stem cell. The methods involve transducing the host cell with the vector in the presence of an inhibitor of mTOR complexes (e.g., rapamycin or analog compound thereof). Also provided in the invention are kits or pharmaceutical combinations for delivering a therapeutic agent into a target cell with enhanced targeting frequency and payload delivery. The kits or pharmaceutical combinations typically contain a viral vector encoding the therapeutic agent, and an inhibitor of mTOR complexes. | 2015-12-10 |
20150352229 | APPARATUS FOR FACILITATING CELL GROWTH IN AN IMPLANTABLE SENSOR - Apparatus is provided that contains cells for implantation into a human subject. The apparatus includes a substantially non-degradable three-dimensional scaffold having surfaces to which the cells are attached, and a hydrogel, which is attached to the cells. The scaffold, the cells, and the hydrogel are arranged such that the cells are sandwiched in spaces between the hydrogel and the surfaces of the scaffold, thereby allowing mobility and proliferation of the cells in the spaces between the hydrogel and the surfaces of the scaffold, and preventing the mobility and the proliferation of the cells to locations outside of the spaces between the hydrogel and the surfaces of the scaffold. | 2015-12-10 |
20150352230 | SYNTHESIS AND ISOLATION OF DENDRIMER BASED IMAGING SYSTEMS - The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents). | 2015-12-10 |
20150352231 | MAGNETIC NANOPARTICLE COMPOSITION AND MANUFACTURING METHOD AND USE THEREOF - The present invention provides a magnetic nanoparticle composition, comprising an iron oxide particle core conjugated with a capping agent and having wüstite structure and antiferromagnetic properties, wherein the empirical formula of iron oxide is defined as Fe | 2015-12-10 |
20150352232 | MR IMAGING DIAGNOSTIC AGENT FOR INTRACTABLE NEUROLOGICAL DISEASE - Disclosed is a compound represented by formula (1) or a salt thereof, | 2015-12-10 |
20150352233 | Polypeptide and Imaging Method - A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); | 2015-12-10 |
20150352234 | COMPOSITIONS AND METHODS FOR TREATMENT AND IMAGING USING NANOPARTICLES - The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect enzyme activity and/or image diseases associated with said enzyme activity. | 2015-12-10 |
20150352235 | TISSUE ALLOGRAFT STERILIZATION METHOD - The invention is a novel method of sterilizing bone and soft tissues intended for human transplantation. In one embodiment the process includes steps of subjecting transplants to high hydrostatic pressures of aqueous fluid to which chlorhexidine gluconate or similar sterilizing chemicals have been added. | 2015-12-10 |
20150352236 | Medical Instrument Sterilization System and Method - A medical instrument sterilization system and method is provided. The system includes a sterilization container having a first container portion engagable with a second container portion to enclose an interior compartment from an exterior atmosphere. At least one insert is locatable within the interior compartment of the sterilization container, the at least one insert having a medical instrument holding area surrounded by a plurality of sidewalls, wherein the medical instrument holding area is sized to hold at least one medical instrument. A filter is secured within a wall of the first container portion, wherein the filter is in communication with the interior compartment and the exterior atmosphere. | 2015-12-10 |
20150352237 | Apparatus and Method for Sanitizing Stethoscope Heads - An apparatus for sanitizing a stethoscope head. The apparatus includes a housing, a reservoir disposed within the housing for containing the sanitizing fluid, one or more applicator pads mounted on the housing, and a dispensing valve for dispensing the sanitizing fluid from the reservoir onto the applicator pad. | 2015-12-10 |
20150352238 | STERILIZATION METHOD AND APPARATUS - A method for controlling condensation of hydrogen peroxide at a preselected temperature within a sealed sterilization chamber including an article to be sterilized includes the steps of applying to the sealed chamber a vacuum of a first pressure sufficient to evaporate, at the preselected temperature, an aqueous solution of hydrogen peroxide of a first concentration. The hydrogen peroxide solution is then evaporated into a water vapor component and a hydrogen peroxide vapor component. The evaporated solution is injected into the sealed chamber in repeated pulses. The injecting is terminated once a preselected second pressure, higher than the first pressure, is reached in the chamber. The pulse volume is selected to allow selective control of the condensation of the hydrogen peroxide vapor component to achieve a layer of micro-condensation of hydrogen peroxide on the article, which layer has a second hydrogen peroxide concentration higher than the first hydrogen peroxide concentration. | 2015-12-10 |
20150352239 | STERILIZABLE ASSEMBLED BRACKET FOR ASEPTIC TECHNIQUE EXPERIMENTS - An assembled sterilization rack for sterile experiment relates to supporting devices used in experiment involving culture of microorganisms and/or cells. The rack includes a lateral frame, retaining wires, connectors, a base frame, heat resistant rods, connecting rings, a temperature-displaying control unit, and N temperature sensors. The lateral frame and the base frame are connected through the connectors. The lateral frame and the base frame have their surfaces facing each other provided with a plurality of retaining wires. The rods have two ends mounted on the symmetrically arranged retaining wires, respectively. The base frame has its upper surface provided with a plurality of connecting rings. The rods have the two ends received in the symmetrically arranged connecting rings, respectively. The temperature sensors are connected with the temperature-displaying control unit. In cell culture experiment, this invention can be applied to support elements used for vertical culture of cells in rectangular culture dishes. | 2015-12-10 |
20150352240 | Active Scrub with Baking Soda for Fridge Freshening and Food Preservation - Sodium Bi-carbonate, more commonly known as Baking Soda, is a chemical often used in killing odor or foul smell emanating from food kept in refrigerators and cooling cabinets and also as a preservative to extend the shelf life of food items. Invention titled “Active Scrub with Baking Soda for Fridge Freshening and Food Preservation” exploits these applications. This invention comprises—a process to scrub the environmental air contained inside the cooling chamber of refrigerators, freezers and cooling cabinets etc; with Baking Soda, using air ballast of the cold air circulation system of respective equipment; and—an attachment to accomplish this process. Such scrubbing facilitates chemical reaction of baking soda with the acidic contents of environmental air and the resultant change in pH in turn helps in killing the odor and extending the shelf-life of contents/food items stored there-in. | 2015-12-10 |
20150352241 | WEARABLE CHEMICAL DISPENSER - Wearable devices for dispensing insect repellents, fragrances, and/or other chemicals along the outside of the clothing of a human are disclosed. They are of the type that are clipped onto a belt or the like, and use a powered fan to dispense active. They are configured with a first timer to account for a passive release rate of the active and a second timer to account for an active release rate of the active. The first time and second timer are in communication with a useful life indicator to provide a signal to a user of the device to indicate when the substrate in the device for containing the active should be replaced. | 2015-12-10 |
20150352242 | AIR PURIFICATION DEVICE - Provided is an air purification device which can suppress production of side products when purifying air. An air purification device comprises a vent body through which air passes, a photocatalyst filter which is provided inside the vent body, an ultraviolet lamp which applies ultraviolet rays to the photocatalyst filter and an ozone lamp which is provided inside the vent body and generates ozone. | 2015-12-10 |
20150352243 | SUBSTRATE COMPRISING A COMPOSITION REDUCING THE ADHERENCE OF FECES OR MENSES TO THE SKIN - A composition applied on a substrate comprised by, or forming, or used for manufacturing of, a disposable absorbent article may be used for reducing the adherence of feces or menses to the human skin. The composition deposited on the substrate does not affect negatively the manufacturing process of the disposable absorbent article and imparts desirable fluid handling properties to the substrate. The composition may also be desirably deposited on a substrate used as, or in a wipe. | 2015-12-10 |
20150352244 | ANTIOXIDANT AND ANTIMICROBIAL WOUND DRESSING MATERIALS - A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag | 2015-12-10 |
20150352245 | METHODS AND DRESSINGS FOR SEALING INTERNAL INJURIES - Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings. | 2015-12-10 |
20150352246 | SEALANTS HAVING CONTROLLED DEGRATION - The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid. | 2015-12-10 |
20150352247 | COMPOSITIONS AND METHODS FOR REGENERATION OF HARD TISSUES - Bone graft compositions including bioactive glass scaffold and characterized in that the bioactive glass scaffold has a high compressive strength, is osteoconductive and osteostimulative and resorbs at a rate consistent with the formation of new bone are described. Also, methods of using the bone grafts for regeneration of hard tissues and, especially, for treating or correcting developmental dysplasia of the hip are provided. | 2015-12-10 |
20150352248 | RESORBABLE CERAMICS WITH CONTROLLED STRENGTH LOSS RATES - Particular aspects of the present disclosure provide bio-resorbable and biocompatible compositions for bioengineering, restoring, or regenerating tissue or bone. In one embodiment, a biocompatible composition includes a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion dopants or metal oxide dopants. The composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss under body, body fluid or simulated body fluid conditions. | 2015-12-10 |
20150352249 | Soft Calcium Hydroxyapatite & a Method for Preparation Thereof Used for Filling Gaps in Human Bone - Provided herein is a method for preparation of soft calcium Hydroxyapatite including: mixing a salt of calcium ion with a polymer to obtain a solution, addition of a salt of phosphate ion with the solution thus obtained to obtain aqueous calcium Hydroxyapatite, freeze drying to obtain soft calcium Hydroxyapatite (HA). The soft calcium Hydroxyapatite is a stable compound, which is sponge like with cellular matrix. When it is filled into a cavity of bone, it makes a wide area contact with bony cage around. | 2015-12-10 |
20150352250 | ARTIFICIAL BONE FORMS AND COMPOSITIONS FOR APPROXIMATING BONE - An artificial bone construct which approximates one or more components of a skeletal system, wherein the artificial construct is used in the testing and development of new surgical procedures, ballistics testing, implantable devices, etc., and wherein the artificial construct closely approximates the physical and mechanical properties of one or more components of a skeletal system. The artificial bone construct can be implanted in a human body. | 2015-12-10 |
20150352251 | DERMAL FILLER COMPOSITIONS INCLUDING ANTIOXIDANTS - Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins. | 2015-12-10 |
20150352252 | CELL CONSTRUCT FOR CELL TRANSPLANTATION, BIOCOMPATIBLE POLYMER BLOCK, AND METHOD FOR PRODUCING THE SAME - It is an object of the present invention to provide a cell construct for cell transplantation that does not contain a substance having cytotoxicity, such as glutaraldehyde, and suppresses the necrosis of the transplanted cells in the construct (namely, having a high cell survival rate). The present invention provides a cell construct for cell transplantation comprising biocompatible polymer blocks that do not contain glutaraldehyde and at least one type of cells, wherein a plurality of biocompatible polymer blocks are disposed in gaps among a plurality of cells, and wherein the biocompatible polymer blocks have a tap density of 10 mg/cm | 2015-12-10 |
20150352253 | INJECTABLE FIBRIN COMPOSITION FOR BONE AUGMENTATION - The present invention relates to a biodegradable injectable composition for bone augmentation comprising fibrin, a contrast agent and calcium salt-containing particles, as well as a method for bone augmentation in a patient suffering from a bone disorder comprising injecting said composition into a non-mineralized or hollow portion of said bone. | 2015-12-10 |
20150352254 | Extracellular Matrix Prostheses for Treating Damaged Biological Tissue - Particulate structures comprising a particulate extracellular matrix (ECM) component encased in a biomaterial composition, which, when administered to damaged cardiovascular tissue, induce modulated healing. | 2015-12-10 |
20150352255 | PREPARATION OF EXTRACELLULAR MATRIX-MODIFIED TISSUE ENGINEERED NERVE GRAFTS FOR PERIPHERAL NERVE INJURY REPAIR - A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft. | 2015-12-10 |
20150352256 | TISSUE PROCESSING APPARATUS WITH MIXING DEVICE AND METHOD FOR PROCESSING ADIPOSE TISSUE - A portable apparatus for collection and processing of human biological material, such as containing adipose extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. The apparatus includes a mixing device disposed at least in part within the tissue retention volume, and wherein the mixing device has a rotatable shaft extending from outside of to inside of the internal containment volume and has at least one mixing member that is disposed in the tissue retention volume with at least a portion disposed in the tapered portion of the internal containment volume and that is connected with the shaft to move through the tissue retention volume when the shaft is rotated. | 2015-12-10 |
20150352257 | DECELLULARIZED BIOMATERIAL FROM NON-MAMMALIAN TISSUE - The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and non-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes. The resultant urodele-derived biomaterial can be used to enhance restoration of skin homeostasis, to reduce the severity, duration and associated damage caused by post-surgical inflammation, and to promote progression of natural healing and regeneration processes. In addition, the biomaterial promotes the formation of remodeled tissue that is comparable in quality, function, and compliance to undamaged human tissue. | 2015-12-10 |
20150352258 | Production of Moldable Bone Substitute - Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability. | 2015-12-10 |
20150352259 | HYDROPHILIC COATING - A coating formulation for preparing a hydrophilic coating, wherein the hydrophilic coating formulation comprises (a) at least one multifunctional polymerizable compound 5 (b) at least one Norrish Type I photoinitiator; and (c) at least one Norrish Type II photoinitiator. | 2015-12-10 |
20150352260 | Medical Item For Prevention and Treatment of Ear Infection - Methods of preventing and treating an ear infection comprising insertion of a tympanostomy tube comprised of a least one anti-biotic agent. | 2015-12-10 |
20150352261 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE - The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ. | 2015-12-10 |
20150352262 | BIODEGRADABLE SUPPORTING DEVICE - A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold. | 2015-12-10 |
20150352263 | MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE - The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ. | 2015-12-10 |
20150352264 | POLYMERIC VASCULAR STENT AND IN VIVO VISUALIZATION THEREOF - This invention is directed to vascular stents that can be visualized in vivo through the use of fluorescent imaging. | 2015-12-10 |
20150352265 | BIOCOMPATIBLE COATING COMPOSITION - Provided herein are hemo-compatible, anti- and non-thrombogenic, heparin-based bioactive coatings for a surface to be contacted with blood, such as a surface of an oxygenator device (e.g., a Hollow Fiber Membrane (HFM) surface) or an artificial lung, which coatings include a quaternary ammonium salt and heparin complex (QUAT). According to example embodiments, the surface is treated with polyvinylpyrrolidone (PVP), followed by a coating layer of said quaternary ammonium salts and heparin complex (QUAT) to form a PVP-QUAT coating. According to other example embodiments, anionic functional groups are created on the one or more surfaces of the HFM by modifying the surface of the HFM using ionic complexes dissolved in a solvent mixture that includes major quantity of alcohol along with a minor quantity of organic dissolving agents. Also provided are methods of making the provided coatings, methods of coating a surface, oxygenator devices and artificial lungs that have been coated, and kits that include such coatings. | 2015-12-10 |
20150352266 | FAT PROCESSING DEVICE - A device for the concentration of a mixture of fatty material and aqueous fluid comprises a chamber for receiving a mixture of fatty material and aqueous fluid, and a body of absorbent material, the chamber being separated from the absorbent material by a barrier member having at least one opening, and a shutter element movable from a closed position, in which said opening is occluded, to an open position, in which said opening permits fluid flow from the chamber to the absorbent material. It has been found that the use of an absorbent material enables fatty material to be concentrated to the required degree in a passive, single vessel process without damage to the fatty tissue. There are also described methods for the use of the device. | 2015-12-10 |
20150352267 | METHOD FOR PROVIDING NEGATIVE PRESSURE TO A NEGATIVE PRESSURE WOUND THERAPY BANDAGE - A method for providing a negative pressure wherein a pump is cycled on and off to achieve a target negative pressure, which is set slightly lower than the therapeutic negative pressure. A device determines the actual pressure by averaging samples which may occur at a different rate than the pump cycle. | 2015-12-10 |
20150352268 | MEDICAL SUCTION SYSTEM AND DISPOSABLE CONTAINER - A portable, adjustable disposable medical suction system and method of use is disclosed. The system includes a delivery device to provide a conduit from a surgical site on a patient to the portable, adjustable medical suction system. The suction system may be a battery powered vacuum pump with one or more different adjustments directed to a strength of the vacuum, duration of the vacuum and interval between suction. The delivery device may be an intranasal tampon device or a tube inserted into the surgical site. During surgery and recovery at a surgical center or hospital, the vacuum source attached to the delivery system may be an industrial type vacuum source. Upon discharge, the suction system can be connected to the delivery system so that bleeding can be resolved by the patient in the comfort of his/her own home. The system and method of use is safer and mitigates body fluid borne contamination. | 2015-12-10 |
20150352269 | ELECTROLYTE AND pH MONITORING FOR FLUID REMOVAL PROCESSES - Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session. | 2015-12-10 |
20150352270 | SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION - A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance. | 2015-12-10 |
20150352271 | MEDICAL DEVICE - A medical device, preferably for peritoneal dialysis, is described which comprises a film tube. | 2015-12-10 |
20150352272 | DEVICE FOR PROMOTING FISTULA PATENCY AND METHOD - A device for promoting patency of a fistula includes an annular body and a plurality of vanes formed integrally with the annular body, and projecting inwardly from an inner radial surface thereof. The vanes are oriented so as to impart circumferential velocity components to blood passed through a lumen of the device, and such that an unobstructed line of sight parallel to a central axis of the annular body extends between adjacent ones of the vanes. | 2015-12-10 |
20150352273 | DEVICE FOR FORMING FISTULA BETWEEN BLOOD VESSELS, AND METHOD - A device for forming a fistula between blood vessels includes a tubular body having a central lumen, a flange attached to the tubular body and projecting outwardly from an outer body surface, and one or more vanes projecting inwardly into the lumen so as to induce helical flow in blood passed through the lumen between first and second vessels joined via the fistula. | 2015-12-10 |
20150352274 | DIAGNOSIS, MONITORING, AND TREATMENT - Some aspects of the invention include methods of treating a patient who has or is at risk of developing kidney disease, methods of selecting a suitable regimen for the prevention or treatment of kidney disease, and to methods of monitoring the effectiveness of a treatment regimen for the prevention or treatment of kidney disease. Other aspects of the invention include medical uses of a binding partner for an anti-IQCJ antibody, and methods of preventing or treating kidney disease in a subject using such binding partners. Still other aspects of the invention include devices for the extracorporeal treatment of a patient's blood. | 2015-12-10 |
20150352275 | PORTABLE CONTACT-WASHING DEVICE FOR RELIEVING AND PREVENTING SYMPTOMS ASSOCIATED WITH HEMORRHOIDS - A portable contact-washing device allows a user to wear a single-use finger cover for contact washing of rectal area using water that is delivered to the finger pad area through micro tubing by a mini water pump. This contact wash uses a limited amount of water for a sufficient hygienic wash to the rectal area after a bowel movement without causing irritation which is often associated of using toilet paper. The contact washing process is efficient and requires a small volume of water, and the contact-washing device is highly portable and easy to use outside of home. The finger cover may be made of biodegradable material and will be discarded after the use. | 2015-12-10 |
20150352276 | POSITIVE DISPLACEMENT PUMP - Systems, methods and apparatuses for delivering therapeutic fluid to the body of a patient are disclosed. The apparatus includes a dispensing unit having a driving mechanism, a pumping mechanism, a reservoir containing therapeutic fluid, and an outlet port. The driving mechanism causes the pumping mechanism to positively displace therapeutic fluid within the reservoir for delivery of therapeutic fluid to the body of the patient via the outlet port. | 2015-12-10 |
20150352277 | EXTRA-CORPOREALLY PORTABLE INFUSION DEVICE - A portable medical apparatus for administering a fluid drug in doses, including a first housing including a reservoir unit with an outlet into a fluid path for conducting the drug, a second housing including a conveying unit for dispensing the drug from the reservoir unit in doses and a suitable controller for controlling the conveying unit, an adaptor including a coupling structure for receiving the first housing and the second housing and an attaching structure for extra-corporeally carrying the adaptor on a patient, wherein the conveying unit and the reservoir unit can be joined together to form an integrated mechanical and fluidic unit, and coupled to and decoupled from at least two differently configured adaptors, wherein at least one of the adaptors is configured to be directly attached to the surface of the skin and at least one of the adaptors is configured to be worn on or carried by an article of clothing or a wearing system (e.g., a belt). | 2015-12-10 |
20150352278 | Infusion Speed Measurement Instrument - An infusion speed measurement instrument | 2015-12-10 |
20150352279 | OCCLUSION SENSING FOR AN INFUSION PUMP - Some embodiments of an infusion pump system may include an occlusion sensor that can be used to detect when an occlusion exists in the fluid path between the medicine reservoir and the infusion site on the user's skin. Such an occlusion may occur, for example, when the fluid flow line (e.g., a cannula, infusion set tubing, or the like) is kinked. If the medicine dispensation path to the user is occluded, the user may receive no dosage or a lower dosage of the medicine. As such, the occlusion sensor can be used to indicate when the fluid is flowing or not flowing, thereby permitting the infusion pump system to communicate an alarm to the user if an occlusion exists. | 2015-12-10 |
20150352280 | INSULIN PUMP APPARATUS, DEVICE, METHODOLOGY AND KIT - A smart insulin pump that is programmable to customize for the physical and mental conditions of a user. A user may input information that may be analyzed by the insulin pump to deliver insulin with appropriate bolus type and basal rate, such as particular or customizable to that user or a group. The insulin pump, apparatus, system, technique, methodology and kit of the present invention includes a computerized controller to analyze, and input and control operations of the pump, delivering the bolus of insulin at an adaptable and varying basal rate better suited to the characteristics of the patient in question. | 2015-12-10 |
20150352281 | Device for Administration of a Pharmaceutical - The invention relates to a device for administration of a pharmaceutical with
| 2015-12-10 |
20150352282 | INSULIN DELIVERY SYSTEMS AND METHODS - A system is provided with an insulin delivery device configured to deliver insulin to a user of the system and a computer-based control unit associated with the insulin delivery device. The computer-based control unit includes a user interface and a computer-based processor. The computer-based processor is configured to calculate a relative insulin on board value for a specific time by calculating a first value that represents a reference insulin on board value at the specific time, calculating a second value that represents an automated insulin on board value at the specific time, and subtracting one of the first and second values from the other. The automated insulin on board value represents at least one insulin delivery automatically specified by the computer-based control unit. Methods of use are also disclosed. | 2015-12-10 |
20150352283 | Device and Method for Automatic Data Acquisition and/or Detection - Methods and system for providing diabetes management including automatic time acquisition protocol and expiration date detection are provided. | 2015-12-10 |
20150352284 | INFUSION PUMP INCLUDING PAIN CONTROLLED ANALGESIC ("PCA") APPARATUS - An infusion pump includes: a housing, a pump actuator supported by the housing, electronics configured to control the pump actuator, a pain controlled analgesic (“PCA”) input device, a cord having a remote end connected to the PCA input device and a local end connected to the housing, a remote integrated circuit; and a local integrated circuit in communication with the electronics and the remote integrated circuit so as to provide operational information concerning the PCA input device to the electronics. | 2015-12-10 |
20150352285 | Injection dart - An improved injection dart is disclosed. A flow restrictor positioned at a forward end of a dart body is provided. The flow restrictor has a generally cylindrical restrictor body portion and a radially outward extending flange portion at a forward end thereof. The flange is securely held in position. The restrictor body also having a recess in a rearward end. The flange portion holds said restrictor in a position where an inner bore of a cannula is precisely aligned with the restrictor bore. The restrictor acts to diminish a variable flow rate so that all flow rates above a maximum flow rate are restricted to be less than the maximum flow rate. The flange also keeps a forward end of the flow channel bore open but allows for radially inward deformation of the restrictor at a rear end of said flow channel bore. | 2015-12-10 |
20150352286 | SYRINGE WITH HANGING TAG - Provided is a syringe having a tag which enables to indicate administration status of a liquid medicament simply and demonstrably and is easy to visually make it check, in administering a liquid medicament to a patient from the syringe by using a syringe pump. | 2015-12-10 |
20150352287 | Pen Type Drug Injection Device with Friction Reducing Dose Encoder Mechanism - A drug delivery device, comprises a housing having a longitudinal axis; an axially moveable component that is moveable along the longitudinal axis between a dose dialing position and a dose delivery position when a user operates the device to deliver a dose of drug; an encoder sleeve; an encoder pattern provided on the encoder sleeve, the encoder pattern comprising relatively conductive portions and relatively non-conductive portions that together comprise coded information; a contact-supporting component; and plural electrical contacts provided on the contact-supporting component. The plural electrical contacts contact the encoder pattern when the dose delivery button is in the dose dialing position and wherein the device is configured to move the contact-supporting component relative to the encoder sleeve as the axially moveable component moves from the dose dialing position to the dose delivery position such as to move the electrical contacts into positions where they do not contact the encoder pattern. | 2015-12-10 |
20150352288 | Medical Injection System with Dose Capturing - The present invention relates to a medical injection system comprising an injection device ( | 2015-12-10 |
20150352289 | Pen Type Drug Injection Device with Low Friction Dose Encoder Mechanism on Thread - A drug delivery device comprises a body component located concentrically within a sleeve, wherein the body component comprises body component thread features and the sleeve comprises sleeve thread features that engage with the body component thread features such that the body component is caused to rotate within the sleeve as the body component and the sleeve component move axially with respect to one another by force of an engaging face of the sleeve thread features against an engaging face of the body component thread features causing sliding of the engaging face of the sleeve thread features over the engaging face of the body component thread features. One of the body component and the sleeve constitutes a first part and the other of the body component and the sleeve constitutes a second part. A conductive track pattern is formed on the thread features of the first part and plural contacts are formed on the second part such as to contact the conductive track pattern as the body component rotates within the sleeve. | 2015-12-10 |
20150352290 | Pen Type Drug Injection Device with Dose Encoder mechanism and Dose Setting/Dose Delivery mode Switch - A drug delivery device comprising: a housing; a plurality of sensors; and a cylindrical member supported within the housing, the outer surface of said cylindrical member being provided with a helical track, the helical track comprising track segments of a first type and track segments of a second type, the first and second types of track segment being respectively capable of inducing first and second responses in the sensors; wherein: the helical track has a width dimension W; the helical track includes across its width at least one track segment of the first type and at least one track segment of the second type at plural positions along the length of the helical track; the device is configured such that during a first phase of a drug delivery operation the helical track is moved axially, without rotation, relative to the plurality of sensors between a first position and a second position, and during a second phase of the drug delivery operation the track is moved helically relative to the plurality of sensors from the second position; and responses induced in the plurality of sensors by the track segments of the helical track are different in the first position compared to responses induced in the plurality of sensors by the helical track in the second position. | 2015-12-10 |
20150352291 | NEEDLE PROTECTION DEVICE - A fluid injection device having a syringe body, a needle, and a needle protection device removable from the injection device and having a substantially flexible or deformable inner body and a substantially rigid outer body. In the stored position the inner body closes the dispenser orifice of the needle and the outer body co-operates with the injection device to fasten the protection device on the injection device. The protection device includes a protection system against accidental pricking, having protective flaps that are integral part of the outer body and movable between a covering position in which they cover the needle, and an open position in which the needle is uncovered. The protection system has a control ring that slides over the outer body so as to move the flaps from their covering position to their open position, before injection, and from their open position to their covering position, after injection. | 2015-12-10 |
20150352292 | SYRINGE WITH TEMPERATURE MODULATION CAPABILITIES - Disclosed herein are syringes having temperature modulation capabilities particularly with regard to changing the temperature of the material being ejected from or injected into the syringe and methods of use. In a specific embodiment of this invention, the syringe comprises a phase transition composition which is to be maintained in one phase within the syringe chamber and ejected in a different phase from the syringe. | 2015-12-10 |
20150352293 | INJECTION DEVICE FOR MINIMALLY INVASIVE PROCEDURES AND USES THEREOF - Provided herein is an injection device that can be used in minimally invasive procedures, such as laparoscopic surgeries, for direct administration of a fluid, such as a therapeutic, to a target tissue or organ. | 2015-12-10 |
20150352294 | SYRINGE PUMP ENGAGEMENT DETECTION APPARATUS AND METHODS - Syringe pump apparatus and methods for detecting proper or improper engagement of a syringe pump drive system with a syringe in the syringe pump are disclosed. The apparatus and methods can determine proper or improper engagement between a drive system and the plunger of a syringe in a syringe pump by detecting the force required to move a plunger clip in reverse while restricting flow into the syringe. The apparatus and methods may also be used to determine that a syringe in the syringe pump apparatus is properly connected to a delivery line. | 2015-12-10 |
20150352295 | Application For Applying A Microneedle Device To Skin - An applicator and method for applying a microneedle device to skin. The applicator can include a housing and a reciprocating support structure slidably engaged with the housing. The reciprocating support structure can have a plurality of alignment feet. The applicator can have a lockout mechanism that prevents actuation if the alignment feet are not evenly aligned. The applicator can include a device life indicator that is capable of counting the number of use cycles that the applicator has undergone and providing feedback to the user. The applicator can include a dose timer capable of determining the time that has elapsed after actuation of the device and providing feedback to the user. | 2015-12-10 |
20150352296 | DEVICE, A SYSTEM AND A METHOD FOR IDENTIFICATION/AUTHENTICATION OF PARTS OF A MEDICAL DEVICE - Disclosed is a dispensing system. The dispensing system includes a dispensing unit to dispense therapeutic fluid, and a validation mechanism to enable operation of the dispensing unit based, at least in part, on a determination of whether operation of the dispensing device is authorized. | 2015-12-10 |
20150352297 | LIQUID DRUG CARTRIDGES AND ASSOCIATED DISPENSER - Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user. | 2015-12-10 |
20150352298 | Medicament Delivery Device - A medicament delivery device for delivering metered doses of medicament, wherein an indicator mechanism ( | 2015-12-10 |
20150352299 | HEATED NEBULIZER ADAPTER FOR RESPIRATORY THERAPY - Systems, methods, and devices are described for heating nebulizer adapters. In certain embodiments, a nebulizer adapter includes a cup having an interior wall defining a gas mixing chamber, an exterior wall, and a fluid cavity disposed between the interior wall and the exterior wall. The nebulizer adapter also includes an inlet port having a fluid lumen in fluid communication with the fluid cavity and a breathing gas inlet lumen in fluid communication with the mixing chamber. The nebulizer adapter further includes an outlet having a breathing gas outlet lumen, and a drain port in fluid communication with the mixing chamber and having a drain lumen that passes from the interior wall to the exterior wall of the cup. | 2015-12-10 |
20150352300 | device for gas heating and humidification by means of magnetic induction for laparoscopy - The present invention relates to a device for heating and humidifying gas for laparoscopy by means of magnetic induction. | 2015-12-10 |
20150352301 | SELF-PUNCTURING LIQUID DRUG CARTRIDGES AND ASSOCIATED DISPENSER - Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient. | 2015-12-10 |
20150352302 | Electrically Operable Resuscitators - The present invention relates to an electrically operable resuscitation device comprising a pump including a rigid cylinder including at least one gas inlet and at least one gas outlet, a piston to travel in said cylinder, and at least one valve, the or each valve configured to allow gas to be displaced into said cylinder through said at least one gas inlet during at least one of a first stroke direction and second stroke direction of said piston in said cylinder, and for allowing gas to displaced through said at least one gas outlet during an opposite of said at least one of the first stroke direction and second stroke direction of said piston in said cylinder; a motor, selected from one of a stepper motor and feedback motor and stepper motor with feedback and linear motor, operatively connected to said piston to move said piston in said cylinder; a patient interface in ducted fluid connection with said pump to receive gas via said at least one gas outlet and to deliver said gas to said patient. | 2015-12-10 |
20150352303 | DEVICE HAVING MANUAL RESUSCITATION AND SUCTION CAPABILITIES - Disclosed is a resuscitator including a valve assembly having a check valve arranged within a valve body, the valve body defining a gas passageway therethrough, the valve body including a first inlet, a second inlet and a first outlet, wherein the second inlet and the first outlet are axially aligned, and the first inlet is axially perpendicular to both the second inlet and the first outlet, and wherein the valve is arranged within the valve body between the second inlet and the first outlet in axial alignment with the second inlet and the first outlet; a compressible bag in fluid communication with the first inlet; a suction device removably attached to the second inlet; and an endotracheal tube removably attached to the first outlet. The suction device includes a tube arranged to be advanced through the valve and into the endotracheal tube such that the endotracheal tube can be suctioned without having to detach the endotracheal tube from the valve body. | 2015-12-10 |
20150352304 | Bite Proof Endotracheal Tube - An endotracheal tube assembly that is constructed to prevent kinking and crushing of the tube due to interaction with the dontia of a patient or a patient position, orientation, or movement. The endotracheal tube assembly includes a tube defined by a hollow core that extends between a first end and a second end of the endotracheal tube assembly. A reinforcement is formed integrally with the endotracheal tube assembly and constructed to prevent constriction of the hollow core. | 2015-12-10 |
20150352305 | RESPIRATORY MASK SEALING INTERFACE - A sealing interface includes an inner cushion and an outer sheath. The outer sheath substantially seals against the facial contours of the user. The inner cushion and the outer sheath each have a nasal bridge region, left and right cheek regions and either one of an upper lip region or a chin region. In use these regions are aligned with the corresponding nasal bridge region, left and right cheek regions and either the upper lip region or the chin region of a user. The inner cushion includes a hinged region. The hinged region is adapted to flex substantially independently of the inner cushion cheek regions. | 2015-12-10 |
20150352306 | PATIENT INTERFACE AND METHOD FOR MAKING SAME - A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member. | 2015-12-10 |
20150352307 | Liner for Use with Respiratory Mask - A liner for use with a respiratory mask having a face-engaging portion having nasal pillows is provided, where the liner includes a body constructed from an absorbent material, the body having a first pair of apertures and a second pair of apertures spaced from the first pair of apertures. The first pair of apertures receives the nasal pillows, and the second pair of apertures is aligned with the nasal pillows when the liner is in a folded configuration. | 2015-12-10 |
20150352308 | PATIENT INTERFACE AND METHOD FOR MAKING SAME - A nasal patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure releasably attachable to the frame member. | 2015-12-10 |
20150352309 | SINGLE USE BREATHING MASK WITH ADHESIVE GASKET - A single use mask having an adhesive gasket is provided. The mask is of a two piece construction including a relatively hard attachment shell and a flexible gasket. The shell serves at the air chamber covering the mouth and nose of the patient as well as the point of attachment for the therapy tubing set. The flexible gasket and adhesive layer serves as the attachment means for affixing the mask to the patient's face. In contrast to the masks of the prior art, the gasket is formed from a sheet of foam material. | 2015-12-10 |
20150352310 | DUAL-CONNECTOR WYE PIECE - A wye connector has a patient coupling end. The patient coupling end has a first connector surface and a second connector surface. The first connector surface has a first diameter at an axial location along the patient coupling end. The second connector surface has a second diameter at the same axial location along the patient coupling end. The first diameter is larger than the second diameter. The second connector surface projects axially outward beyond the first connector surface. | 2015-12-10 |
20150352311 | Breathing Apparatus Detection and Purging - Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. The methods may also include purging the nasal cannula if it is reconnected after a disconnection or if it is replaced by a new cannula. Other methods pertain to automatic purging of the delivery conduit if the elapsed time between successive deliveries of therapeutic gas exceeds a predetermined period of time. | 2015-12-10 |
20150352312 | VENTILATION INTERFACE FOR SLEEP APNEA THERAPY - The ventilation interface for sleep apnea therapy interfaces a ventilation device to the patient's airways. The ventilation interface includes a pair of nasal inserts made from flexible, resilient silicone which are oval shaped in cross-section and slightly tapered from a base proximal the ventilation supply to the distal tip end. A bead flange is disposed about the exterior of each insert at the distal end of the insert. A bleed port for release of exhaled air is defined through a conical vent projecting normally to the path of the incoming air flow, and continues through a nipple extending to the exterior of the air conduit. In one embodiment, a pair of nasal inserts are integral with a nasal cannula body, with bleed ports axially aligned with each insert. In another embodiment, each insert is independently connected to a separate, thin-walled, flexible supply line. | 2015-12-10 |
20150352313 | METHODS AND SYSTEMS FOR GATHERING HUMAN BIOLOGICAL SIGNALS AND CONTROLLING A BED DEVICE - Introduced are methods and systems for an adjustable bed device configured to: gather biological signals associated with multiple users, such as heart rate, breathing rate, or temperature; analyze the gathered human biological signals; and heat or cool a bed based on the analysis. | 2015-12-10 |
20150352314 | SYSTEMS FOR ENHANCING SLEEP - Methods, devices and systems for improving sleep (including reducing sleep onset and maintenance of sleep duration), enhancing, or increasing sleep, including (but not limited to) treating sleeping disorders such as insomnia. | 2015-12-10 |