49th week of 2015 patent applcation highlights part 28 |
Patent application number | Title | Published |
20150344813 | LUBRICATING OIL COMPOSITIONS - A lubricating oil composition having a sulphated ash content of less than or equal to 1.2 mass % as determined by ASTM D874 and a phosphorous content of less than or equal to 0.12 mass % as determined by ASTM D5185, which lubricating oil composition comprises or is made by admixing: an oil of lubricating viscosity, in a major amount; an oil-soluble or oil-dispersible polymeric friction modifier as an additive in an effective minor amount; and, an oil-soluble or oil-dispersible dihydrocarbyl dithiophosphate metal salt as an additive in an effective minor amount. | 2015-12-03 |
20150344814 | Low-Ash Lubricating Oils For Diesel Engines - The lubricant for a sump-lubricated, compression-ignited engine may contain an amount of a C12-C24 carboxylic acid-based fuel additive or component obtained by migration from the fuel. Good lubricant performance is obtained by including in the lubricant a boron-containing additive in an amount to provide about 2 to about 500 ppm B to the lubricant, provided that the total sulfated ash level is less than 0.8 weight percent. | 2015-12-03 |
20150344815 | Multi-Step Separation Process - The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using an eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.0, wherein the PUFA product is other than alpha-linolenic acid (ALA), gamma-linolenic acid (GLA), linoleic acid, an ALA mono- di- or triglyceride, a GLA mono- di- or triglyceride, a linoleic acid mono- di- or triglyceride, an ALA C | 2015-12-03 |
20150344816 | DERIVATIVES OF FATTY ESTERS, FATTY ACIDS AND ROSINS - Provided is a compound of Formula (I); where R | 2015-12-03 |
20150344817 | WATER CLUSTER-DOMINANT BORONIC ACID ALKALI SURFACTANT COMPOSITIONS AND THEIR USE - An aqueous alkali-surfactant solution having a hydroxide molarity of from 2 to 9 M that comprises alkali and a surfactant having a boron-centered head group positioned terminally in a linear or branched aliphatic or aryl hydrocarbon chain comprising from 4 to 10 carbon atoms. The boron-centered head group can be selected from boronic acids and their derivatives. Boronic acid alkali-surfactant treatment processes, such as cleaning, chemical pulping, mercerization, metal processing, leather processing, food processing, and personal beauty care. The process comprises the step of contacting a substrate with an effective amount of an aqueous boronic acid alkali-surfactant composition. | 2015-12-03 |
20150344818 | WATER CLUSTER-DOMINANT ALKALI SURFACTANT COMPOSITIONS AND THEIR USE - Alkali surfactant treatment processes, such as cleaning, chemical pulping, mercerization, metal processing, leather processing, food processing, and personal beauty care. The process comprises the step of contacting a substrate with an effective amount of an aqueous alkali surfactant composition having a hydroxide Molarity of from 2 to 9. The composition comprises (a) alkali; and (b) a surfactant having a Lewis acid head group positioned terminally in a linear or branched aliphatic or aryl hydrocarbon chain comprising from 4 to 10 aliphatic carbon atoms. | 2015-12-03 |
20150344819 | WATER CLUSTER-DOMINANT ALKALI SURFACTANT COMPOSITIONS AND THEIR USE - Alkali surfactant compositions and treatment processes. The alkali surfactant composition has a surface tension (at 100 ms) of from [0.8 asymptote] to [1.2 * asymptote]. The composition can be used in treatment processes, such as cleaning, chemical pulping, mercerization, metal processing, leather processing, food processing, and personal beauty care. The process comprises the step of contacting a substrate with an effective amount of an aqueous alkali surfactant composition having a hydroxide Molarity of from 2 to 9. The composition comprises (a) alkali; and (b) a surfactant having a Lewis acid head group positioned terminally in a linear or branched aliphatic hydrocarbon chain comprising from 4 to 10 aliphatic carbon atoms. | 2015-12-03 |
20150344820 | COMPOSITIONS AND METHODS FOR BIOFILM TREATMENT - Cleaning compositions and methods for the treatment of biofilms. The cleaning composition is an aqueous alkali surfactant composition comprising an alkali salt and a surfactant agent having a Lewis acid head group attached to a short hydrophobic tail group. The methods for treating biofilm comprise contacting the affected surfaces with the cleaning composition. | 2015-12-03 |
20150344821 | OPTIMIZED SURFACTANT RATIO FOR IMPROVED RINSE FEEL - The invention relates to a detergent composition having a ratio of surfactants optimized for clean rinse feel. | 2015-12-03 |
20150344822 | Decontaminant and Process for Decontamination of Chemicals from Infrastructural Materials - A decontaminant and method for decontaminating an infrastructural system is disclosed, the decontaminant including from about 3% to about 5%, by weight, of a permanganate compound; from about 8% to about 12%, by weight, of a strong mineral acid; and from about 80% to about 90%, by weight, of a solvent. | 2015-12-03 |
20150344823 | AUTOMATIC DISHWASHING DETERGENT COMPOSITION - An automatic dishwashing detergent composition comprising:
| 2015-12-03 |
20150344824 | NOVEL CLEANING METHOD - The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the polymeric particles comprise at least one antimicrobial agent. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one additional cleaning agent, and in this embodiment, it is preferred that the polymeric particles are mixed with the at least one additional cleaning agent. Preferably, the additional cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fibre. Typically, the polymeric particles comprise particles of polyester or nylon, most preferably in the form of beads. The results obtained are very line with those observed when carrying out conventional aqueous cleaning processes and the method provides the significant advantage that the use of antimicrobial agents in or on the polymer bead greatly improves the overall hygiene in the washing machine by preventing mould and bacterial growth on the polymer particle surfaces, particularly at low temperatures. | 2015-12-03 |
20150344825 | COMPOSITIONS FOR CLEANING III-V SEMICONDUCTOR MATERIALS AND METHODS OF USING SAME - Liquid compositions useful for the cleaning of residue and contaminants from a III-V microelectronic device material, such as InGaAs, without substantially removing the III-V material. The liquid compositions are improvements of the SC1 and SC2 formulations. | 2015-12-03 |
20150344826 | AQUEOUS CLEANING COMPOSITION CONTAINING COPPER-SPECIFIC CORROSION INHIBITOR FOR CLEANING INORGANIC RESIDUES ON SEMICONDUCTOR SUBSTRATE - A semiconductor wafer cleaning formulation, including 1-35% wt. fluoride source, 20-60% wt. organic amine(s), 0.1-40% wt. nitrogenous component, e.g., a nitrogen-containing carboxylic acid or an imine, 20-50% wt. water, and 0-21% wt. metal chelating agent(s). The formulations are useful to remove residue from wafers following a resist plasma ashing step, such as inorganic residue from semiconductor wafers containing delicate copper interconnecting structures. | 2015-12-03 |
20150344827 | Active Containing Fibrous Structures with Multiple Regions - A fibrous structure including filaments wherein the filaments comprise one or more filament-forming materials and one or more active agents that are releasable from the filament when exposed to conditions of intended use, the fibrous structure further having at least three regions. Methods of treating fabrics with a fibrous structure are also provided herein. | 2015-12-03 |
20150344828 | SELF-ASSEMBLING CELL AGGREGATES AND METHODS OF MAKING ENGINEERED TISSUE USING THE SAME - A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure. | 2015-12-03 |
20150344829 | CELL CULTURE BAG AND METHOD FOR MANUFACTURING CELL CULTURE BAG - A cell culture bag is provided. The cell culture bag includes: an external film of the cell culture bag; at least one sensor chip arranged on a culture fluid side of the external film, the at least one sensor chip including a layer reacting to an object to be detected; and a permeable film that covers a culture fluid side of the sensor chip, the permeable film permeating the object to be detected. | 2015-12-03 |
20150344830 | LARGE SCALE MIXOTROPHIC PRODUCTION SYSTEMS - Bioreactor systems for culturing mixotrophic microorganisms in open cultures on a large scale are disclosed herein. Embodiments of the system comprise organic carbon delivery systems and submersible thrusters suspended on adjustable support structures. | 2015-12-03 |
20150344831 | STIMULATION-RESPONSIVE MATERIAL AND CELL CULTURE CONTAINER MADE THEREOF - A stimulation-responsive material comprises regions of pH-responsive polymer and regions of temperature-responsive polymer, the regions existing at different locations. | 2015-12-03 |
20150344832 | MIXING DEVICE FOR HOMOGENIZATION OF CELL SUSPENSIONS - The invention is directed to a homogenization device for cell suspensions, comprising a first rotating magnet; a shaft on which a propeller mixer is attached which rotates around the longitudinal axis of the shaft and is movable in lateral direction of the axis of the shaft; the propeller mixer being provided with at least two propeller blades of which at least one is provided with a second magnet; wherein the propeller mixer is rotated by magnetic interaction of the second magnet with the first rotating magnet. | 2015-12-03 |
20150344833 | MEDIUM EXCHANGE SYSTEM - Supply and discharge of a solution, such as a medium, in a cell culture bag are easily controlled. Provided is a system including a sac-like cell culture bag having a supply port for supplying a solution, such as a medium, to the inside and having a discharge port for discharging the solution, such as a medium, from the inside, wherein gate opening and closing means for opening and closing inner holes of the supply port and the discharge port are attached to the supply port and the discharge port, and the gate opening and closing means are controlled to easily exchange the medium or the like in the cell culture bag. | 2015-12-03 |
20150344834 | System, Method and Devices for Tissue-Based Diagnosis - Described are devices, methods and systems for applying energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied tissue sample. The liquefied tissue sample may be removed from the tissue of interest. Also described are compositions of the liquefaction promoting medium that may facilitate liquefaction, preserve liquefied tissue constituents, and/or enable delivery of molecules into tissues. The sample may include tissue constituents to provide for rapid tissue sampling, tissue decontamination as well as detection of analytes. One or more drugs may be delivered through or into the tissue of interest. Determination of tissue composition in the liquefied tissue sample can be used, e.g., for diagnosis or prognosis of diseases, evaluating bioavailability of therapeutic agents in different tissues following administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and the like. | 2015-12-03 |
20150344835 | INCUBATOR WITH CONTROLLED ILLUMINATION - The incubator has a climate-controlled chamber with a plurality of containers located therein. Each container can receive a sample plate and is adapted with light sources for exposing the samples to light. The incubator further comprises a handling device for transferring sample plates between the containers and a transfer location positioned outside an automatic door. A cooling unit is provided for carrying off excess heat from the light sources. | 2015-12-03 |
20150344836 | Agrobacterium Strains for Plant Transformation and Related Materials and Methods - Described herein are materials, methods, and kits useful for | 2015-12-03 |
20150344837 | MINIMAL BACTERIAL GENOME - The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 100 genes listed in Table 2; and/or wherein (2) the gene set comprises the 382 protein-coding genes listed in Table 3 and, optionally, one of more of: a set of three genes encoding ABC transporters for phosphate import (genes MG410, MG411 and MG412; or genes MG289, MG290 and MG291); the lipoprotein-encoding gene MG185 or MG260; and/or the glycerophosphoryl diester phosphodiesterase gene MG293 or MG385. | 2015-12-03 |
20150344838 | REDUCED GENOME E. COLI - Reduced genome strains of | 2015-12-03 |
20150344839 | Components for Animal Feed and Use Thereof - A fermented liquid feed composition for a target animal is provided, the feed composition being prepared by the fermentation of a feed substrate with a lactic acid producing bacteria, the lactic acid bacteria being characterised by being viable under the conditions prevailing in the gastrointestinal tract of the target animal, being an aggregating bacteria and/or co-aggregating with one or more pathogens, and being able to produce upon fermentation in the feed substrate lactic acid in an amount of at least a minimum inhibitory concentration of lactic acid. A method of producing a fermented liquid feed composition is also provided. Preferred lactic acid producing bacteria for use in the composition and method are | 2015-12-03 |
20150344840 | BACTERIAL HOST STRAIN - A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest. | 2015-12-03 |
20150344841 | LACTOBACILLUS HAVING ABILITY TO INDUCE IL-12 PRODUCTION, AND METHOD FOR CULTURING SAME - A method of producing a large volume of | 2015-12-03 |
20150344842 | METHOD FOR PRODUCTION OF DECELLULARIZED BIOLOGICAL MATERIAL AND THE DECELLULARIZED BIOLOGICAL MATERIAL PREPARED THEREFROM - The invention provides a method for decellularization of a biological material to obtain a decellularized biological material. Compared to untreated biological material, the content of DNA of the decellularized biological material of the invention decreases to a low level and there is no significant reduction of glycosaminoglycan and collagen. The invention also provides a decellularized biological material prepared from the method of the invention and a support comprising the decellularized biological material. | 2015-12-03 |
20150344843 | DETERGENT TREATED BIOLOGICAL TISSUE WITH LOW RESIDUAL DETERGENT AND METHOD OF PRODUCING THE SAME - This invention relates to a detergent treated biological tissue with low residual detergent and methods of making the same. The low residual detergent is a clinically beneficial aspect of the biological tissue. | 2015-12-03 |
20150344844 | METHODS FOR PRODUCING AUTOLOGOUS T CELLS USEFUL TO TREAT B CELL MALIGNANCIES AND OTHER CANCERS AND COMPOSITIONS THEREOF - Provided herein are methods for manufacturing T cells. In certain embodiments, methods for manufacturing T cells which express a cell surface receptor that recognizes a specific antigenic moiety on the surface of a target cell are provided. Such methods may include, but are not limited to, steps of (1) enriching a population of lymphocytes obtained from a donor subject; (2) stimulating the population of lymphocytes with one or more T-cell stimulating agents to produce a population of activated T cells, wherein the stimulation is performed in a closed system using serum-free culture medium; (3) transducing the population of activated T cells with a viral vector comprising a nucleic acid molecule which encodes the cell surface receptor, using a single cycle transduction to produce a population of transduced T cells, wherein the transduction is performed in a closed system using serum-free culture medium; and (4) expanding the population of transduced T cells for a predetermined time to produce a population of engineered T cells, wherein the expansion is performed in a closed system using serum-free culture medium. Also provided herein are populations of engineered T cells produced by the methods described herein and pharmaceutical compositions thereof. | 2015-12-03 |
20150344845 | METHODS, KITS, AND COMPOSITIONS FOR STEM CELL SELF-RENEWAL - The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population. | 2015-12-03 |
20150344846 | Compositions of Active WNT Protein - Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein. | 2015-12-03 |
20150344847 | Method For Production Of Large Numbers Of Cartilage Cells With Phenotype Retention - A method for production of large numbers of cartilage cells with phenotype retention intended for treatment of articular cartilage lesions or preparing viable cartilage tissue by propagation of chondrocytes from cartilage explants, human or animal, with the retention of phenotypes of the cartilage cells, in which cells are chondrocytes retaining morphologic attributes of the same or chondrocyte progenitor cells. The method includes culturing the cells in which cultured cells are organized into mature hyaline cartilage on the surface of biologic structures such as cancellous or cortical bone lamina. The method for culturing chondrocytes to produce three dimensional cellular structures consisting of cartilage cells and cell produced extracellular cartilage matrix. | 2015-12-03 |
20150344848 | SULFATED DEPOLYMERIZED DERIVATIVES OF EXOPOLYSACCHARIDES (EPS) FROM MESOPHILIC MARINE BACTERIA, METHOD FOR PREPARING SAME, AND USES THEROF IN TISSUE REGENERATION - The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml. | 2015-12-03 |
20150344849 | EX VIVO CULTURE, PROLIFERATION AND EXPANSION OF INTESTINAL EPITHELIUM - Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time. Mammalian intestinal cells cultured by the methods of the invention recapitulate features of intestinal growth in vivo. | 2015-12-03 |
20150344850 | BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES - The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides. | 2015-12-03 |
20150344851 | RECOMBINANT MICROORGANISM AND METHOD FOR PRODUCING A SUBSTANCE USING THE SAME - This invention provides a recombinant microorganism into which an acyl-CoA reductase exhibiting excellent activity in a reduction reaction using acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding an acyl-CoA reductase comprising any of characteristic Common sequences 1 to 3 introduced into a host microorganism. | 2015-12-03 |
20150344852 | DIAPHORASE - [Object] To provide: a novel diaphorase; a method for producing the diaphorase; and use of the diaphorase. | 2015-12-03 |
20150344853 | CONSTRUCTION OF NEW VARIANTS OF DEXTRANSUCRASE DSR-S BY GENETIC ENGINEERING - The present invention relates to a recombinant process for the production of truncated or mutated dextransucrases while conserving the enzymatic activity or their specificity in the synthesis of the α-1,6 bonds. The present invention relates to nucleic acid sequences of truncated or mutated dextransucrases, vectors containing the nucleic acid sequences and host cells transformed by sequences encoding truncated or mutated dextransucrases. In another aspect, the invention concerns a method for producing, in a recombinant manner, truncated or mutated dextransucrases which conserve their enzymatic activity or which conserve their specificity in the synthesis of α-1,6 bonds and can produce, from saccharose, dextrans with high molar mass and modified rheological properties compared with the properties of dextran obtained with the native enzyme and isomalto-oligosaccharides with a controlled molar mass and dextrans. The dextrans and isomalto-oligosaccharides of the invention can be used namely as texturing agents or as prebiotics. | 2015-12-03 |
20150344854 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. | 2015-12-03 |
20150344855 | A Soluble Fibroblast Growth Factor Receptor 3 (FGR3) Polypeptide For Use In The Prevention Or Treatment Of Skeletal Growth Retardation Disorders - The present invention relates to the prevention or treatment of skeletal growth retardation disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3. More particularly, the present invention relates to a soluble FGFR3 for use in the prevention or treatment of achondroplasia. | 2015-12-03 |
20150344856 | PROCESS FOR THE PRODUCTION OF OLIGOSACCHARIDES FROM LIGNOCELLULOSIC BIOMASS - A process for producing oligosaccharides from lignocellulosic biomass, having the following steps:
| 2015-12-03 |
20150344857 | Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2015-12-03 |
20150344858 | NOVEL MANNANASE, COMPOSITIONS AND METHODS OF USE THEREOF - The present compositions and methods relate to an endo-beta-mannanase cloned from | 2015-12-03 |
20150344859 | COMPOSITION FOR USE IN MYCOBACTERIA THERAPY - The present invention relates to a composition having the activity of degrading the cell wall of a | 2015-12-03 |
20150344860 | Polypeptides Having Protease Activity - The present invention relates to isolated polypeptides having protease activity, and the use of isolated polypeptides having protease activity in animal feed. It also relates to the use of isolated nucleic acid sequences encoding the proteases in the recombinant production of isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also relates to nucleic acid constructs, vectors, and host cells, including plant and animal cells, comprising the nucleic acid sequences, as well as methods for producing and using the proteases, particularly using the proteases in animal feed. | 2015-12-03 |
20150344861 | MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS - The present invention relates to novel mutants of Streptokinase, its functional fragments and covalently modified forms. Methods are provided for the preparation of the bacterial plasminogen activator protein, Streptokinase its muteins, species variants and their covalently modified variants that are characterized by improved therapeutic properties, such as increased proteolytic stability, extended plasma half-lives, reduced immuno-reactivity and enhanced fibrin clot specificity. The method involves either incorporating additional cysteine residues, or substituting cysteine residues for naturally occurring amino acids into non-essential regions of the protein such that the catalytic activity of the resultant protein remains largely unaltered. These cysteine variants were further modified by covalently attaching a cysteine reactive polymer such as polyethylene glycol (PEG) or sulfhydryl-reactive moieties from a group that includes fluorophore, spin labels or other small conjugates. Disclosed herein are site-specific biologically active conjugates of Streptokinases and its covalently modified variants. | 2015-12-03 |
20150344862 | COAGULATION FACTOR IX COMPOSITIONS AND METHODS OF MAKING AND USING SAME - The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions. | 2015-12-03 |
20150344863 | SHORT-ACTING FACTOR VII POLYPEPTIDES - Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding. | 2015-12-03 |
20150344864 | CHEMICALLY MODIFIED CYSTATHIONINE BETA-SYNTHASE ENZYME FOR TREATMENT OF HOMOCYSTINURIA - The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders. | 2015-12-03 |
20150344865 | Method of Production of Rare Disaccharides - The present invention is directed towards genetic modification of native gene encoding for sucrose isomerase and isomaltulose synthase to substantially increase the expression level of these enzymes and use of said enzymes in a process to produce rare disaccharides such as isomaltulose and trehalulose. Also disclosed in the present invention is expression constructs comprising the modified genes and a host cells to express the same. | 2015-12-03 |
20150344866 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF HISTIDYL-TRNA SYNTHETASES - Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | 2015-12-03 |
20150344867 | HIGHLY POTENT CELLULOLYTIC ENZYME PREPARATIONS AND PROCESSES FOR PRODUCING SAME - Compositions comprising unprocessed cell pellets of a cellulosome-producing microorganism grown on cellulosic biomass are provided. Further provided are methods for producing the compositions and uses thereof in hydrolysis of cellulosic substrates. In particular, the compositions advantageously contain extracellular beta-glucosidase, either expressed on the cells themselves or extrinsically added to the cell pellets. | 2015-12-03 |
20150344868 | METHODS AND SYSTEMS FOR ULTRASONIC LYSIS - Methods and systems for cell lysis are disclosed. Particular embodiments relate to applying acoustic energy to a biological sample located in a sample chamber. | 2015-12-03 |
20150344869 | TRANSFECTION WITH MAGNETIC NANOPARTICLES - The invention includes a magnetic nanoparticle molecular delivery vehicle to be used for transfection and delivery of therapeutic molecules across cell membranes and to specific sites in the body, using magnetic forces and ultrasound. | 2015-12-03 |
20150344870 | NUCLEIC ACID EXTRACTION - A method and device for extracting nucleic acids from a biological sample is described. The device includes a substrate, such as a cellulose filter, functionalised with a biocidal agent having multiple functional groups including a binding moiety, which is involved in binding the agent to the substrate; a hydrophobic moiety; and a charged moiety. The various functional groups serve to bind the agent to the substrate, weaken or lyse the cell wall or membrane of the sample, and retain nucleic acids on the substrate. A preferred biocidal agent is a silylated quaternary ammonium compound (SiQAC), for example 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. | 2015-12-03 |
20150344871 | System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells - Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences. | 2015-12-03 |
20150344872 | METHODS OF SYNTHESIS OF OLIGONUCLEOTIDE TAGGED COMBINATORIAL LIBRARIES AND USES THEREOF - Provided herein are methods of synthesis of a compound which includes a functional moiety operatively linked to a tagging oligonucleotide, libraries thereof and methods of using the compound and libraries thereof to identify compounds which bind to a target. | 2015-12-03 |
20150344873 | Whole Genome Mapping by DNA Sequencing With Linked-Paired-End Library - The present invention relates to innovative means of generating sequence-linked DNA fragments and subsequent uses of such linked DNA fragments for de novo haplotype-resolved whole genome mapping and massively parallel sequencing. In various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme, or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments, and methods of de novo whole genome mapping. Thus, the methods of this invention allow establishing sequence contiguity across the whole genome, and achieving high-quality, low-cost de novo assembly of complex genomes. | 2015-12-03 |
20150344874 | Screening method for drug target gene using heterozygous deletion fission yeast strain - The present invention relates to a screening method for a drug target gene by using chemical-genetic profile compendium of the heterozygous deletion fission yeast strain and the comparative genetic analysis using the same. More precisely, the present inventors constructed the chemical-genetic profile compendium for drug candidates from the heterozygous deletion fission yeast strain of | 2015-12-03 |
20150344875 | Isolating Biological Modulators from Biodiverse Gene Fragment Libraries - The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of:
| 2015-12-03 |
20150344876 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS - The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes). | 2015-12-03 |
20150344877 | METHODS FOR TREATING VIRAL INFECTIONS - The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation such compounds. In particular, the present invention relates to the use of nucleic acid constructs to identify or validate compounds capable of modulating the efficiency of programmed ribosomal frameshifting and the use of said compounds to inhibit the replication or infectivity of viruses that employ programmed ribosomal frameshifting. | 2015-12-03 |
20150344878 | Compositions and Methods for Treatment of Mitochondrial Diseases and for Differentiation of Cells to Neurons - Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a Pumilio-like protein and/or an inhibitor of a serine/arginine-rich family of pre-mRNA splicing factor (SR) protein to a subject. Also provided are methods, compositions, systems and kits for transdifferentiating target cells to neurons, which find use in producing neurons for the development of new therapies, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example, for use in treating human disorders of the CNS. | 2015-12-03 |
20150344879 | COMPOUNDS AND METHODS FOR MODULATING GENE EXPRESSION - The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing. | 2015-12-03 |
20150344880 | COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS - The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed. | 2015-12-03 |
20150344881 | METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES - The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays. | 2015-12-03 |
20150344882 | COMPOSITIONS AND METHODS TO PROMOTE BONE FORMATION - This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis. | 2015-12-03 |
20150344883 | METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES - The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays. | 2015-12-03 |
20150344884 | INHIBITORY OLIGONUCLEOTIDES AND THEIR USE IN THERAPY - Inhibitory oligonucleotide having the general formula: | 2015-12-03 |
20150344885 | HBV TREATMENT - RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes. | 2015-12-03 |
20150344886 | RNAi-Related Inhibition of TNF-alpha Signaling Pathway for Treatment of Ocular Angiogenesis - RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition, such as ocular angiogenesis, retinal ischemia, and diabetic retinopathy. | 2015-12-03 |
20150344887 | siRNA FOR INHIBITION OF USP15 EXPRESSION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME - Disclosed herein is an siRNA that inhibits the expression of USP 15 protein and a pharmaceutical composition containing the same for preventing or treating cancers. According to the present invention, the siRNA of the present invention inhibits the expression of USP 15 protein thereby substantially inhibiting the growth and metastasis of cancer cells. | 2015-12-03 |
20150344888 | USP30 INHIBITORS AND METHODS OF USE - Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided. | 2015-12-03 |
20150344889 | Methods and Compositions for Inducing Deregulation of EPHA7 and ERK Phosphorylation in Human Acute Leukemias - Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed. | 2015-12-03 |
20150344890 | Modulation of Insulin Like Growth Factor I Receptor Expression in Cancer - Provided herein are methods, compounds, and compositions for reducing expression of an IGF-IR mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions that inhibit expression of IGF-IR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate the tumor or cancer, or a symptom thereof. | 2015-12-03 |
20150344891 | REDUCTION OF TGF BETA SIGNALING IN MYELOID CELLS IN THE TREATMENT OF CANCER - Methods of inhibiting metastasis in cancer patients are provided, wherein the methods comprise reducing TGFβ signaling, for example, by reducing TGFβ receptor II expression in myeloid cells. Vectors comprising a TGFβ receptor II RNAi nucleic acid sequence operably linked to a myeloid specific promoter also are provided. A method of diagnosing cancer in an individual by determining TGFβ receptor II expression in myeloid cells in the individual is provided. Additionally, a method of modulating TGFβ activity in myeloid cells in a cancer patient comprising administering a regulator of at least one of the GSK3 and PI3K pathways to the patient is provided. | 2015-12-03 |
20150344892 | OLIGONUCLEOTIDES FOR MODULATION OF TARGET RNA ACTIVITY - The present invention relates to oligonucleotides for modulation of target RNA activity. Thus, the invention provides oligonucleotides that bind to microRNA binding sites of target RNA. The oligonucleotides may activate RNase H or RNAi. In a preferred embodiment, the oligonucleotides prevents a micro RNA from binding to its binding site of the target RNA and thereby prevent the microRNA from regulating the target RNA. Such oligonucleotides have uses in research and development of new therapeutics. | 2015-12-03 |
20150344893 | METHODS AND COMPOSITIONS FOR REGULATION OF TRANSGENE EXPRESSION - Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom. | 2015-12-03 |
20150344895 | METHODS OF MODIFYING ALGAL CELL GENOMES - A method of introducing a target gene sequence into a primed algal cell, comprising a step of providing a primed algal cell comprising providing an algal cell; introducing into the algal cell an integration cassette comprising at least two site-specific recombination sites and at least one selectable marker gene wherein the at least two site-specific recombination sites are positioned to flank the at least one selectable marker gene; and selecting cells which have incorporated the integration cassette by cultivating the cells in a selective media and selecting growing cells, wherein an ability of the cells to be cultured on the selective media is dependent on a presence of the at least one selectable marker in a genome of the algal cell. The site-specific recombination sites may be compatible. The method includes a further step of effecting targeted site-specific recombinase mediated deletion of the target cassette can be carried out. The site-specific recombination sites maybe heterospecific to permit introduction of target gene(s). The method further comprises a step of providing a target cassette comprising at least one target gene sequence flanked by a type I site-specific recombination site and a type II site-specific recombination site, these sites being capable of recombining with those in the primed algal cell. Moreover, the method includes a further step of effecting targeted site-specific recombinase mediated insertion of the target cassette into the algal genome by effecting recombination between corresponding type I and type II site-specific recombination sites flanking the target gene sequence and located in the algal genome, such that the target gene sequence is introduced into the algal genome replacing the at least one selectable marker. The invention also concerns integration cassettes for use in the method above, as well as an algal cell for use with and modified algal cell produced by the above method. | 2015-12-03 |
20150344896 | System For Expression Of Genes In Plants From A Virus-Based Expression Vector - Modified expression vectors, including Tobacco Mosaic Virus (TMV) expression vectors, methods for modifying such vectors, and uses of the same are disclosed. | 2015-12-03 |
20150344897 | MONOCOTYLEDON TRANSGENIC METHOD FOR INVADING GROWING POINTS OF SEED BUDS MINIMALLY AND FULLY - The present invention is a method of shoot apical meristem transformation for monocot plant via sufficient and micro wounding (SMW). The technical process includes: expose the apical meristem by removing the coleoptile away when the shoot grows to 0.2-2 cm after 1-2 days of seed germination; make sufficient and micro wounding transformation to the apical meristem by stabbing and brushing for 2-3 times using the SMW brush having 100-5000 bristles which is 4-20 μm in diameter for each one and 0.5-3 mm in exposed length, and dipped with the | 2015-12-03 |
20150344898 | TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 2015-12-03 |
20150344899 | Transgenic Plants With Enhanced Traits - This disclosure provides plants having enhanced traits such as increased yield, increased nitrogen use efficiency and increased water use efficiency; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with the composition or with enhanced traits. | 2015-12-03 |
20150344900 | METHODS FOR ENHANCING ROOT GROWTH OF PLANTS - The present invention relates to a method for enhancing root growth of a plant by introducing a polynucleotide encoding late embryogenesis abundant protein, group 3 (LEA3) into the plant. Plant root architecture is essential for its functions in water and nutrient uptake, anchorage and interactions with microbes in the soil. | 2015-12-03 |
20150344901 | PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME - The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a WI12-like (WIL) polypeptide or a SAWADEE-like polypeptide or a POZ-like (Pox virus and Zn Finger) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a WIL polypeptide or a SAWADEE-like polypeptide or a POZ-like polypeptide, which plants have enhanced yield-related traits relative to control plants. The invention also provides hitherto unknown WIL-encoding nucleic acids, and constructs comprising the same, and hitherto unknown POZ-like encoding nucleic acids, and constructs comprising the same, useful in performing the methods of the invention. | 2015-12-03 |
20150344902 | Resistance to Acetohydroxyacid Synthase-Inhibiting Herbicides - Nucleotide sequences are disclosed that may be used to impart herbicide resistance to green plants. The sources of novel herbicide resistance were originally isolated in mutant rice plants. The sequences impart pre-emergence resistance, post-emergence resistance, or both pre-emergence resistance and post-emergence resistance to multiple herbicides. To date, resistance has been demonstrated against at least the following herbicides: imazethapyr, imazapic, imazapyr, imazamox, sulfometuron methyl, imazaquin, chlorimuron ethyl, metsulfuron methyl, rimsulfuron, thifensulfuron methyl, pyrithiobac sodium, tribenuron methyl, and nicosulfuron. Green plants transformed with these sequences are resistant to these herbicides and to derivatives of these herbicides, and to at least some of the other herbicides that normally inhibit acetohydroxyacid synthase (AHAS), particularly imidazolinone and sulfonylurea herbicides. | 2015-12-03 |
20150344903 | Novel Herbicide Resistance Genes - The subject invention provides novel plants that are not only resistant to 2,4-D and other phenoxy auxin herbicides, but also to aryloxyphenoxypropionate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention alone or “stacked” together with another herbicide resistance gene, preferably a glyphosate resistance gene, so as to provide broader and more robust weed control, increased treatment flexibility, and improved herbicide resistance management options. More specifically, preferred enzymes and genes for use according to the subject invention are referred to herein as AAD (aryloxyalkanoate dioxygenase) genes and proteins. No α-ketoglutarate-dependent dioxygenase enzyme has previously been reported to have the ability to degrade herbicides of different chemical classes and modes of action. This highly novel discovery is the basis of significant herbicide tolerant crop trait opportunities as well as development of selectable marker technology. The subject invention also includes related methods of controlling weeds. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the formation of, and controlling, weeds that are resistant (or naturally more tolerant) to one or more herbicides such as glyphosate. | 2015-12-03 |
20150344904 | SQUASH HYBRID SV0474YG AND PARENTS THEREOF - The invention provides seed and plants of squash hybrid SV0474YG and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of squash hybrid SV0474YG and the parent lines thereof, and to methods for producing a squash plant produced by crossing such plants with themselves or with another squash plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants. | 2015-12-03 |
20150344905 | COMPOSITIONS AND METHODS FOR CONTROLLING FUNGAL AND BACTERIAL DISEASES IN PLANTS - The present invention provides a fungicidal composition comprising a strain of | 2015-12-03 |
20150344906 | LETTUCE VARIETY 41-115 RZ - The present invention relates to a | 2015-12-03 |
20150344907 | Retinal OFF circuit-specific promoter - The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 200 bp having at least 70% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in cones and/or OFF bipolar cells of a gene when operatively linked to a nucleic acid sequence coding for said gene. | 2015-12-03 |
20150344908 | METHOD OF GENETICALLY ALTERING AND PRODUCING ALLERGY FREE CATS - A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its offspring. | 2015-12-03 |
20150344909 | Vectors And Methods For Genetic Immunization - Improved DNA vaccine plasmids are disclosed that contain novel immunostimulatory RNA compositions. The improved plasmids eliminate all extraneous sequences, incorporate a novel antibiotic free short RNA based selectable marker, increase eukaryotic expression using a novel chimeric promoter, improve yield and stability during bacterial production, and improve immunostimulation. These vectors are utilized in immunization to elicit improved immune responses or therapy to induce type 1 interferon production. | 2015-12-03 |
20150344910 | METHODS FOR CONTROLLING STEM CELL DIFFERENTIATION - Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having Xic, Tsix, or Xite sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small RNA molecules and methods for using the small RNA molecules to control stem cell differentiation. Also disclosed are stem cells genetically modified by the introduction of Xic, Tsix, or Xite sequences. | 2015-12-03 |
20150344911 | RECOMBINANT ADENO-ASSOCIATED VECTORS FOR TARGETED TREATMENT - Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery. | 2015-12-03 |
20150344912 | COMPOSITION FOR CLEAVING A TARGET DNA COMPRISING A GUIDE RNA SPECIFIC FOR THE TARGET DNA AND CAS PROTEIN-ENCODING NUCLEIC ACID OR CAS PROTEIN, AND USE THEREOF - The present invention relates to targeted genome editing in eukaryotic cells or organisms. More particularly, the present invention relates to a composition for cleaving a target DNA in eukaryotic cells or organisms comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof. | 2015-12-03 |
20150344913 | RECOMBINANT MICROORGANISM AND METHOD FOR PRODUCING A SUBSTANCE USING THE SAME - This invention provides a recombinant microorganism into which an acyl-CoA reductase exerting excellent activity in a reduction reaction involving the use of acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding a protein (a) or (b) below introduced into a host microorganism: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence having 70% or higher identity to the amino acid sequence of SEQ ID NO: 2 and having activity for synthesizing an aldehyde compound from acyl-CoA. | 2015-12-03 |