48th week of 2014 patent applcation highlights part 44 |
Patent application number | Title | Published |
20140349330 | METHODS FOR AGGREGATION AND DIFFERENTIATION OF MAGNETIZED STEM CELLS - The invention relates to a process which enables optimal aggregation of cells, typically of stem cells, promoting the organisation thereof and advantageously the differentiation thereof, in particular in the context of the formation of a tissue substitute. This process comprises exposing pretreated cells to a magnetic field and makes it possible to obtain large cell aggregates, even prepared in the absence of support matrix and/or of growth factor. The invention also relates to the cell aggregates that can be obtained using such a process and also to the uses thereof as tissue initiators with a view to obtaining a tissue structure of interest in vitro, ex vivo or in vivo. Moreover, it relates to the resulting tissue structures and to the uses thereof in research or in therapy as tissue substitutes. The present application also provides a method which advantageously makes it possible to monitor the development of the tissue of interest in vivo. | 2014-11-27 |
20140349331 | USE OF BACILLUS COMPOSITION FOR INCREASING THE AMOUNT OF AVAILABLE SUGARS IN ANIMAL FEED - Described are methods for assaying whether a | 2014-11-27 |
20140349332 | METHOD AND DEVICE FOR EXAMINING MYOCARDIAL TOXICITY AND EVALUATING CARDIOMYOCYTE - A method wherein a mass of cardiomyocytes is disposed on a transparent substrate and the quality of the cardiomyocytes is evaluated from the response of the cardiomyocytes to a forced pulsation stimulus that is applied to the pulsating cardiomyocytes. The mass of cardiomyocytes, which is disposed on the transparent substrate, is exposed to the flow of a drug-containing liquid in such a manner as to allow the drug to act on cells configuring a network. The level of cardiotoxicity caused by the drug is evaluated by measuring the fluctuations obtained from a comparison of adjacent pulsating cardiomyocytes of the network. | 2014-11-27 |
20140349333 | METHOD FOR INSPECTING SUSCEPTIBILITY OF BACTERIA OR FUNGI TO ANTIMICROBIAL DRUG AND SYSTEM FOR USE IN THE SAME - The present invention provides a novel method capable of easily and rapidly inspecting the susceptibility of bacteria or fungi to an antimicrobial drug and an inspection system for use in the method. The inspection method of the present invention is a method for inspecting susceptibility of bacteria or fungi to an antimicrobial drug using a micro-device having a flow channel, including: an incubating step of incubating a mixture of the antimicrobial drug and a bacterial suspension to be inspected in the flow channel of the micro-device; and a detecting step of detecting bacteria or fungi derived from the bacterial suspension to be inspected in an observation area of the flow channel of the micro-device. The detecting step can be performed by detecting an increase or decrease in the number of or a change in shape of bacteria or fungi derived from the bacterial suspension to be inspected in the observation area by a microscope or the like. | 2014-11-27 |
20140349334 | NON-INVASIVE IMAGING TO THE BLASTOCYST STAGE FOR THE DETECTION OF HUMAN EMBRYONIC ANEUPLOIDY - Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid. | 2014-11-27 |
20140349335 | METHOD OF DETECTING A BIOLOGICAL ACTIVITY - The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative. | 2014-11-27 |
20140349336 | SAMPLE VIAL FOR DIGITAL HOLOGRAPHIC ANALYSIS OF A LIQUID CELL SAMPLE - The current invention concerns a sample vial for receiving a liquid cell sample, to be used in conjunction with a digital holographic microscope (DHM), said sample vial comprises at least two compartments in fluid connection with one another, said compartments comprising at least one pair of screening surfaces, said screening surfaces are essentially flat; and characterized in that the distance between the pair of screening surfaces of the second compartment is smaller than the distance between the pair of screening surfaces of the first compartment. In a second and third aspect, the current invention pertains to a method and system for analyzing a liquid cell sample by DHM, employing the sample vial of the current invention. | 2014-11-27 |
20140349337 | RAMAN SPECTROSCOPY FOR DETECTION OF GLYCATED ANALYTES - The present invention relates to the optical measurement of blood analytes, such as glycated hemoglobin (HbA1c) and serum albumin as a functional metric of mean blood glucose in the diagnosis of diabetic patients. Non-enhanced Raman spectroscopy is employed as the analytical method for quantitative detection of blood analytes. Using processing techniques, non-enzymatic glycosylation (glycation) of the analytes results in measurable and highly reproducible changes in the acquired spectral data, which enable the accurate measurements and classification of glycated and unglycated analytes. | 2014-11-27 |
20140349338 | BACTERIA AND THE USES THEREOF - The present invention relates to novel bacteria and the uses thereof. The invention particularly relates to bacteria having a metabolic pathway ratio between Pentose phosphate and glycolysis greater than 0.5, and their uses in the chemical, pharmaceutical or agro-chemical industries, e.g., for producing compounds of industrial interest. | 2014-11-27 |
20140349339 | PmST3 ENZYME FOR CHEMOENZYMATIC SYNTHESIS OF ALPHA-2-3-SIALOSIDES - The present invention provides novel methods for preparing glycosylated molecules such as oligosaccharides, glycolipids, and glycoproteins/peptides. Novel sialyltransferases are also disclosed. The method includes forming a reaction mixture containing an acceptor molecule, a donor substrate having a sugar moiety and a nucleotide, and a sialyltransferase selected from PmST3 (SEQ ID NO:7) and certain variants thereof. The reaction mixture is formed under conditions sufficient to transfer the sugar moiety from the donor substrate to the acceptor molecule, thereby forming the glycosylated molecule. In some embodiments, the acceptor molecule is selected from a natural product, an oligosaccharide, a glycoprotein, and a glycolipid. In some embodiments, the donor substrate is formed via conversion of a suitable hexosamine derivative to a cytidine 5′- monophosphate(CMP)-sialic acid in a one-pot reaction mixture containing asialic acid aldolase and a CMP-sialic acid synthetase. | 2014-11-27 |
20140349340 | MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS - The present invention relates to the preparation of β-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation. | 2014-11-27 |
20140349341 | PRODUCTION OF RECOMBINANT PROTEINS WITH SIMPLE GLYCOFORMS - The present invention provides cell lines deficient in mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I (Mgat1). Also provided are methods for producing the Mga1 deficient cell lines and methods for using the Mgat1 deficient cell lines for the production of recombinant proteins having simple glycoforms. | 2014-11-27 |
20140349342 | INTERLEUKIN-6 RECEPTOR BINDING POLYPEPTIDES - The invention relates to amino acid sequences that are directed against and/or that can specifically bind to IL-6 receptor, compounds or constructs that comprise said amino acid sequence, nucleic acids that encode said amino acid sequences, compounds or constructs, pharmaceutical compositions comprising said amino acid sequences, compounds or constructs as well as methods for the prevention and/or treatment of diseases and disorders associated with IL-6 receptor. | 2014-11-27 |
20140349343 | Use of lysozyme as a tag - The present disclosure provides a method to express and purify polypeptides and proteins. In the present disclosure the use of lysozyme as a fusion partner is disclosed. Furthermore, purification methods to isolate lysozyme-tagged polypeptides and proteins via lysozyme-specific antibodies are described. More specifically, the present disclosure provides a method to express and purify monomeric polypeptides and proteins by using lysozyme as a tag. | 2014-11-27 |
20140349344 | COMPOSITIONS AND METHODS FOR PURIFYING BAX - Disclosed are compositions and methods for purifying a Bax protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2014-11-27 |
20140349345 | CYCLOPEPTIDE FERMENTATION AT INCREASED METAL ION CONCENTRATION - The present invention relates to a method for the fermentation of cyclopeptides such as pneumocandins in the presence of increased concentrations of any or all of calcium, copper, iron, magnesium, manganese, molybdenum and zinc ions. | 2014-11-27 |
20140349346 | NEW ACTINOMYCETE INTEGRATIVE AND CONJUGATIVE ELEMENT FROM ACTINOPLANES SP. SE50/110 AS PLASMID FOR GENETIC TRANSFORMATION OF RELATED ACTINOBACTERIA - The present invention is directed to an innate DNA sequence within the complete genome sequence of | 2014-11-27 |
20140349347 | SYNTHESIS OF N-ACETYL-D-NEURAMINIC ACID - Method of making NANA from NAM, which may itself be made from fructose. The NAM is treated with pyruvic acid or a pyruvate in the presence of a NANA aldolase having at least 70% sequence similarity or homology to the amino acid sequence of SEQ. ID. NO. 1. | 2014-11-27 |
20140349348 | Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides - The present invention relates to mutated and/or transformed microorganisms for the synthesis of various compounds. More specifically, the present invention discloses microorganisms mutated in the genes encoding for the regulators ArcA and IclR. The latter mutations result in a significant upregulation of the genes that are part of the colanic acid operon. Hence, said microorganisms are useful for the synthesis of any compound being part of the colanic acid pathway such as GDP-fucose, GDP-mannose and colanic acid, and/or, can be further used—starting form GDP-fucose as a precursor—to synthesize fucosylated oligosaccharides or—starting from GDP-mannose as a precursor—to synthesize mannosylated oligosaccharides. In addition, mutations in the genes coding for the transcriptional regulators ArcA and IclR lead to an acid resistance phenotype in the exponential growth phase allowing the synthesis of pH sensitive molecules or organic acids. | 2014-11-27 |
20140349349 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES - The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate, or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | 2014-11-27 |
20140349350 | Novel Process for the Preparation of Intermediates of HMG-CoA Reductase Inhibitors - The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of HMG-CoA reductase inhibitors. | 2014-11-27 |
20140349351 | Production of 5-Hydroxymethylfurfural From Fructose - The present invention relates to a process for producing 5-hydroxymethylfurfural (HMF) from fructose in a single-phase aqueous solution comprising an organic solvent. | 2014-11-27 |
20140349352 | Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof - Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide. | 2014-11-27 |
20140349353 | ENGINEERED STRAIN OF ESCHERICHIA COLI FOR PRODUCTION OF POLY-R-3-HYDROXYALKANOATE POLYMERS WITH DEFINED MONOMER UNIT COMPOSITION AND METHODS BASED THEREON - Methods and systems for producing prescribed unit size poly(3-hydroxyalkanoate) (PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one fatty acid substrate that is equal in carbon length to the prescribed or desired unit size of the PHA polymer to be produced. The prescribed unit size PHA that is produced is then isolated and/or purified. | 2014-11-27 |
20140349354 | METHOD OF PRODUCING CHEMICAL SUBSTANCE - A method produces a chemical product by continuous fermentation including filtering a culture liquid of a microorganism(s) through a separation membrane, retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid, adding a fermentation feedstock to the culture liquid, and recovering a product in the filtrate, wherein the microorganism(s) is/are a microorganism(s) that undergo(es) catabolite repression, and the fermentation feedstock comprises hexose and pentose. | 2014-11-27 |
20140349355 | POLYCARBOXYLIC ACID EXTRACTION - The invention pertains to method for recovering polycarboxylic acid from an aqueous mixture including the steps of: providing an aqueous mixture including polycarboxylic acid and at least 5 wt. % dissolved halide salt, based on the total weight of water and dissolved material in the aqueous mixture; extracting the polycarboxylic acid from the aqueous mixture into a first organic liquid including an organic solvent selected from the group consisting of ketones and ethers, thereby obtaining an organic polycarboxylic acid solution and an aqueous waste liquid including the halide salt; and extracting the polycarboxylic acid from the organic carboxylic acid solution into an aqueous liquid, thereby obtaining an aqueous polycarboxylic acid solution and a second organic liquid. The method according to the invention allows a combined purification and concentration step for feed solutions of polycarboxylic acids. | 2014-11-27 |
20140349356 | METHOD FOR REUSING WATER IN FERMENTED BUTANEDIOIC ACID SEPARATION PROCESS - This invention belongs to the field of biochemical engineering and relates to a method of cyclic utilization of water during separation of succinic acid made by fermentation. This invention uses water from separation process for aerobic growth of | 2014-11-27 |
20140349357 | METHODS OF PRODUCING BUTANOL FROM NON-CELLULOSIC BIOMASS - Methods of recovering butanol, and preferably increasing the rate and/or yield of its production, from the fermentation of material derived from the digestion of non-cellulosic biomass. | 2014-11-27 |
20140349358 | METHOD FOR INJECTING A FEED GAS STREAM INTO A VERTICALLY EXTENDED COLUMN OF LIQUID - A process for conversion of syngas to liquid products that serve as surface acting agents uses the gas stream at a relatively low pressure to eliminate the use of a compressor. The process uses a liquid stream as the primary energy input to a gas injector that intensely mixes gas and the liquid with reduced compression costs while the presence of the liquid product maintains the gas-liquid dispersion as it flows downward to build a static pressure head. The process lowers the required gas pressure by adjusting the elevation of the gas injector such that a conduit receives the gas-liquid dispersion from the outlet of the injector and confines it as it travels downward to enter the bottom of a column of liquid. The liquid product provides a surface acting agent that prolongs the creation and duration of microbubbles in the gas-liquid dispersion. | 2014-11-27 |
20140349359 | METHODS USING PERACIDS FOR CONTROLLING CORN ETHANOL FERMENTATION PROCESS INFECTION AND YIELD LOSS - A process for the use of peracid compositions to eliminate and/or control the growth of undesirable bacteria, including contaminating bacteria, in the fermentation production of alcohol is disclosed. Beneficially, the peracid compositions and methods of use of the same do not interfere or inhibit the growth or replication of yeast and have low or no adverse environmental impact. | 2014-11-27 |
20140349360 | METHODS AND SYSTEM FOR LIQUEFACTION, HYDROLYSIS AND FERMENTATION OF AGRICULTURAL FEEDSTOCKS - Treatment of agricultural biomass without separation of the biomass to extract fermentable feedstock, instead using a hydrolytic process upstream of the fermentation process, provides an efficient and cost-effective process for forming ethanol from agricultural biomass. | 2014-11-27 |
20140349361 | Process for Converting Biomass to Aromatic Hydrocarbons - The present invention provides methods, reactor systems, and catalysts for increasing the yield of aromatic hydrocarbons produced while converting biomass to hydrocarbons. The invention includes methods of using catalysts to increase the yield of benzene, toluene, and mixed xylenes in the hydrocarbon product. | 2014-11-27 |
20140349362 | MICROORGANISMS AND PROCESSES FOR THE PRODUCTION OF ISOPRENE - The present invention provides a novel biosynthetic pathway for the production of isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol. Further embodiments provide non-naturally occurring microorganism that have been modified to produce isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol and methods of producing isoprene using said microorganism. | 2014-11-27 |
20140349363 | Biogas Plant And Method For Operating A Biogas Plant - A biogas plant has at least one fermenter ( | 2014-11-27 |
20140349364 | BIOGAS PRODUCING SYSTEM - A method for producing biogas by anaerobic digestion of organic matter may involve feeding organic matter suitable for biogas production to a first tank reactor, and in the first tank reactor, contacting the organic matter with biogas producing microorganisms for digestion under anaerobic conditions. The organic matter may be digested in the first tank reactor while producing biogas. The method may further involve providing digested sludge from an anaerobic digestion process in a second tank reactor, which differs from the first tank reactor, the digested sludge containing a desired composition of nutriments. The nutriments may be fed into the first tank reactor. | 2014-11-27 |
20140349365 | PROCESS AND SYSTEM FOR RECOVERING PHOSPHORUS FROM WASTEWATER - Methods and systems for recovery of phosphorus from wastewater and producing inorganic phosphorus complexes. | 2014-11-27 |
20140349366 | PROCESS FOR DESORBING CO2 FROM ION-RICH MIXTURE WITH MICRO-PARTICLES COMPRISING BIOCATALYSTS - A process for desorbing CO | 2014-11-27 |
20140349367 | Hydrolytically Degradable Micellar Hydrogels - Degradable and biologically inert hydrogel networks are described. The hydrogel networks are crosslinked and based on a biocompatible polymer that is chain extended with hydrophobic segments that include no more than 5 hydrophobic monomers to form a macromonomer that is then crosslinked to form a network that includes individual micelles throughout the crosslinked network. The hydrophobic segments of the macromonomer as well as other potentially toxic materials such as crosslink initiators can be sequestered in the micelles to better control degradation characteristics of the network as well as prevent toxicity to developing cellular structures of the network. | 2014-11-27 |
20140349368 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE - The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension. | 2014-11-27 |
20140349369 | HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES - The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides. | 2014-11-27 |
20140349370 | NOVEL VECTOR CONTAINING MULTIPLE NUCLEOTIDE SEQUENCES FOR THE EXPRESSION OF ENZYMES - An expression vector is provided. The vector includes a promoter configured to drive the expression of the transgene in the cell. The vector also includes a tag sequence encoding a tag peptide directing the protein of the expressed transgene to a pre-determined location. The vector further includes a cleavage sequence encoding a peptide that is recognizable by a protease and a marker gene configured to encoding a protein to indicate the expression of the transgene. | 2014-11-27 |
20140349371 | Protein Refolding Method - The present invention provides a method for producing a protein which has a restored native higher-order structure by bringing a protein which has lost its native higher-order structure into contact at pH 6.5 to 9.0 with a 1 to 3% aqueous solution of a specific surfactant, such as lauroylglutamic acid to obtain a solubilized solution of the protein; and then adding the solubilized solution to a buffer with pH 6.5 to 9.0 containing arginine or an arginine derivative at a concentration of 0.1 to 1.2 M to lower the concentration of the specific surfactant, such as lauroylglutamic acid, in the obtained mixture solution down to 0.02 to 0.275%. According to the present invention, it is possible to easily restore the native higher-order structure of a protein while smoothly removing the surfactant from the protein. | 2014-11-27 |
20140349372 | Lipase Variants and Polynucleotides Encoding Same - The present invention relates to lipase variants and methods of obtaining them. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2014-11-27 |
20140349373 | PROCESS FOR THE PRODUCTION OF AN ENZYMATIC COCKTAIL USING SOLID RESIDUES FROM A PROCESS FOR THE BIOCHEMICAL COVERSION OF LIGNOCELLULOSIC MATERIALS - The present invention concerns a process for the production of an enzymatic cocktail by submerged culture with a cellulolytic microorganism, comprising two phases:
| 2014-11-27 |
20140349374 | BACULOVIRUS SYSTEM FOR THE EXPRESSION OF A GENE THERAPY VECTOR - The invention concerns a recombinant baculovirus genome useful for the expression of gene therapy vectors by means of a single infection. | 2014-11-27 |
20140349375 | METHYLSULFONYLMETHANE (MSM) TO MODULATE MICROBIAL ACTIVITY - Disclosed herein are methods of use of methylsulfonylmethane (MSM) to modulate microbial activity, such as to enhance or inhibit the activity of microorganisms. In one example, MSM (such as about 0.5% to 5% MSM) is used to enhance fermentation efficiency, such as to enhance fermentation efficiency associated with the production of beer, cider, wine, a biofuel, dairy product or any combination thereof. Also disclosed are in vitro methods for enhancing the growth of one or more probiotic microorganisms and methods of enhancing growth of a microorganism in a diagnostic test sample. Methods of inhibiting microbial activity are also disclosed. In one particular example, a method of inhibiting microbial activity includes selecting a medium that is susceptible to H1N1 influenza contamination; and contacting the medium with MSM at a concentration of about 10% to about 16% of weight by volume, thereby inhibiting H1N1 influenza microbial activity. | 2014-11-27 |
20140349376 | BETA-ALANINE/ALPHA-KETOGLUTARATE AMINOTRANSFERASE FOR 3-HYDROXYPROPIONIC ACID PRODUCTION - The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof. | 2014-11-27 |
20140349377 | MATRIX AND COMPOSITION FOR MICROBIAL CULTURE OF GRAM-POSITIVE BACTERIA - A composition for fermentation or microbial culture of gram-positive bacteria, includes fibril cellulose and at least one nutrient source including at least one carbon source, at least one nitrogen source, at least one phosphorus source, at least one mineral source and at least one trace element source. | 2014-11-27 |
20140349378 | Biomass Fertilization Vessels - A system for collecting and/or harvesting biomass comprises a first module adapted to accept a fluid stream. The first module includes a gate that is adapted to regulate the flow of the fluid stream. The system includes a second module downstream of the first module. The second module accepts a fluid from the first module and directs at least a portion of the fluid to the first module. A third module downstream of the second module includes one or more surfaces for retaining one or more microorganisms upon the flow of at least a portion of the fluid stream through the third module. | 2014-11-27 |
20140349379 | Impeller Apparatus and Dispersion Method - A method and apparatus for dispersing and entraining and controlling the residence time, absorption and release of gas bubbles or particles in a fluid without losing gas utilization efficiency from escaping surface gas events. A mechanical, rotating plurality of hollowed blades that induce both an axial and radial controlled circulatory flow and provide a means of gas introduction into the discharge flow that has a conical helical, axial and radial outward flow from the axis of rotation and allows entrained gas bubbles to be trapped as particles and recirculated by means of a circulatory flow back into the intake vortex of said mechanical, rotating plurality of blades. The flow is characterized by a forced intake vortex caused by a low pressure zone with a radial component, and subsequent axial component drawing fluid in a circular fashion toward the eye of the rotating device and impelling fluid. The gas entrained flow, while passing through the discharge outlet, can be considered a single phase fluid due to a low pressure differential between the intake side of the rotating blade and the external side of the rotating blade, preventing gas particles from expansion and or compression which could result in a stalled or flooded condition. The flow is further characterized as leaving the rotating body at an angle falling between perpendicular to the axis of rotation and the vessel wall, resulting in low surface turbulence in the vessel and the formation of a circulatory flow that allows the fluid to move down the vessel wall to be pulled in again by the intake vortex. The gas introduction provides sufficiently small enough bubbles to be entrained by a strong circulatory flow with a strength determined by rotational speed and blade angle. | 2014-11-27 |
20140349380 | BIOPOLYMER OPTOFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid. | 2014-11-27 |
20140349381 | PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM - An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general. | 2014-11-27 |
20140349382 | ASSAY OF FUNCTIONAL CELL VIABILITY - The present invention relates to an apparatus for, and methods of assessing cell viability in a biological sample comprising cells or tissue. In particular the present invention provides quality assurance assays for complex biomaterials, especially but not exclusively cells derived from the pancreas, liver, kidney, lung, bone marrow and stem cells, for use in biomedical procedures. The present invention provides inter alia methods of improving assessment of donor cell/tissue viability, methods of improving the success of donor cell/tissue transplant procedures, methods of assessing the functional properties of complex biological materials prior to their use in regenerative therapies and kits therefor. | 2014-11-27 |
20140349383 | FLUORESCENT SENSOR AND SENSOR SYSTEM - A fluorescent sensor includes a detecting substrate, an indicator, a filter layer, a light blocking layer, and an LED chip. In the detecting substrate, a PD element for converting fluorescence into electric signals is positioned on wall surfaces of a through-hole which penetrates a first main surface and a second main surface. The indicator is arranged inside the through-hole and generates fluorescence of intensity corresponding to analyte density when the indicator receives excitation light. The filter layer covers the PD element, transmits fluorescence and blocks excitation light. The light blocking layer, through which an analyte can pass, covers an opening of the first main surface of the through-hole. The LED chip covers a region just below an opening of the second main surface of the through-hole, and generates excitation light. | 2014-11-27 |
20140349384 | COMPOSTER - In a composter having a horizontally elongated rotating drum, material is fed into the drum through an opening in a stationary end plate having an annular marginal area which overlaps, in sealing relationship, an annular intake end wall of the drum. Material passes through a central opening in an annular exit end wall of the drum, and falls by gravity onto a cylindrical screen which is fixed to, and rotates with, the exit end wall. The annular end walls are in axial register with, and surrounded by, external trunnions on the drum which ride on pairs of supporting rollers. Frusto-conical rings are welded to the end walls, and to the inside of the drum at locations opposite the edges of the trunnion rings to reduce metal fatigue. The exit end rollers allow for axial expansion of the drum. The interior wall the drum is lined with a rubber. | 2014-11-27 |
20140349385 | SINGLE-USE MIXING AND BIOREACTOR SYSTEMS - Disclosed are magnetic agitation mixing systems for use with flexible container reaction vessels. In one aspect of the invention, the orientation of magnetic coupling between the impeller magnets and the external driver magnets is modified such that the coupling is neither strictly axial nor strictly radial. Also disclosed are “receiver-less” retainer configurations whereby the single-use container need not have a rigid base that defines a cup or post to engage of rotatable agitator. | 2014-11-27 |
20140349386 | ULTRA-HIGH-SPEED NUCLEIC ACID EXTRACTING APPARATUS AND NUCLEIC ACID EXTRACTING METHOD USING SAME - A nucleic acid extraction device, which can realize automation, ultra-miniaturization and super-high speed in the nucleic acid extraction reaction, has no limitation to the type of biological specimens that can be used, such as sputum, blood, cells, urine, saliva, tissues, etc., minimize the used amount of the sample solution, and also maintain and/or improve the nucleic acid extraction efficiency with reliability. | 2014-11-27 |
20140349387 | Sampling Device - The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including an outer sheath; a plurality of tubes within the sheath, in which at least one of the tubes acquires a sample, and at least one of the tubes expels a fluid that is immiscible with the sample, in which the at least one tube that acquires the sample is extendable beyond a distal end of the sheath and retractable to within the sheath; and a valve connected to a distal portion of the sheath, in which the valve opens when the tube extends beyond the distal end and closes when the tube retracts to within the sheath. | 2014-11-27 |
20140349388 | System And Process For Separating A Material - Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations. | 2014-11-27 |
20140349389 | PROCESSES FOR THE DIGESTION OF COLANIC ACID - The present disclosure generally relates to processes employing polypeptides having colanic acid-degrading activity. The processes generally involve contacting a biological material with a polypeptide capable of digesting colanic acid. Additional process steps, such as chromatographic separation steps, are also described. | 2014-11-27 |
20140349390 | IN VIVO DELIVERY OF NUCLEIC ACIDS TO THE LIVER OR LIVER TISSUE - The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell. | 2014-11-27 |
20140349391 | METHOD OF COLLECTING PLACENTAL STEM CELLS - A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom. | 2014-11-27 |
20140349392 | DEVICE FOR CULTURING CELLS - The invention relates to a device for culturing cells, which device comprises a bottom wall, at least one side wall as well an upper wall for forming an interior volume that can be shut off from the outside world, a liquid culture comprising cells being present on the bottom wall in use, between the at least one side wall, to which volume fluid can be supplied via at least one supply channel disposed in the upper wall and from which fluid can be discharged via at least one discharge channel disposed in the upper wall. | 2014-11-27 |
20140349393 | Fusion Partner for Production of Monoclonal Rabbit Antibodies - The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications. | 2014-11-27 |
20140349394 | TARGETED INTEGRATION INTO THE PPP1R12C LOCUS - Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest. | 2014-11-27 |
20140349395 | ANTI-CD40 ANTIBODIES AND METHODS OF USE - The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases. | 2014-11-27 |
20140349396 | Compositions and Methods Relating to Clonal Progenitor Cells - Aspects of the present invention include methods and compositions related to the production and use of clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells. In particular, said methods and compositions relate to methods of differentiating cells in the presence of agents that inhibit the signaling of the TGF beta family members of growth factors and the applications of said cell lines in the treatment of diseases such as degenerative muscle disorders, cancer, and vascular disease. | 2014-11-27 |
20140349397 | REPROGRAMMING IMMORTALIZED B CELLS - Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement. | 2014-11-27 |
20140349398 | ENDOTHELIAL CELL PRODUCTION BY PROGRAMMING - The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects. | 2014-11-27 |
20140349399 | Compositions and Methods for Diagnosing and Treating Cancer - The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth. | 2014-11-27 |
20140349400 | Programmable Modification of DNA - A self-reconfiguring genome uses a cassette having operons or DNA sequences that code for guide RNA, reverse transcriptase, donor RNA, and a CRISPR cleavage enzyme. A self-reconfiguring genome may be based on lambda recombineering of in situ generated oligonucleotides. A method for programmable self-modification of a cellular genome includes transcribing guide RNA from a self-reconfiguring cassette, associating the transcribed guideRNA with the CRISPR enzyme, intercalcating a region of complimentary sequence within an integration site of the genome, cutting upstream of a PAM site within the integration site; transcribing the donorRNA, translating donorRNA to double-stranded DNA, and recombining the double-stranded DNA via homologous recombination at the cut site of the integration site. A set of cascadable and multiplexable genetic logic gates with a universal RNA input/output based on single-strand annealing or non-homologous end joining, comprises transcription promoters or terminators, homologous regions, DNA sequences, RNA, and enzymes from the CRISPR system. | 2014-11-27 |
20140349401 | FEEDER-FREE DERIVATION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS WITH SYNTHETIC MESSENGER RNA - The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed. | 2014-11-27 |
20140349402 | CAR+ T CELLS GENETICALLY MODIFIED TO ELIMINATE EXPRESSION OF T-CELL RECEPTOR AND/OR HLA - The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for “off-the-shelf treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negative T cells are generated using zinc finger nucleases, for example. | 2014-11-27 |
20140349403 | LARGE COMMERCIAL SCALE LENTIVIRAL VECTOR PRODUCTION SYSTEM AND VECTORS PRODUCED THEREBY - In accordance with the present invention, a method for increasing the yield of rLV vector particles comprising a trans gene encoding a therapeutic protein or fragment thereof is disclosed. In one approach, cells are transfected with plasmids encoding the necessary components for rLV production using a calcium chloride transfection mix at pH 7.1 wherein the calcium chloride and plasmids form a complex which is added to the cells at a constant speed. The cells are then incubated for a suitable time period wherein virus particle media is collected at least twice during the incubation period and stored in a cold storage unit, thereby reducing virus inactivation. | 2014-11-27 |
20140349404 | METHOD FOR GENE TRANSFER - Disclosed is a simple and highly efficient method for introducing a gene into a target cell using a retrovirus vector. The method comprises the steps of (a) placing a liquor containing a retrovirus vector having a foreign gene carried thereon into a bag for cell culture on which a retrovirus-binding substance has been immobilized, and incubating the liquor at a temperature lower than 25° C. for 8-48 hours, thereby producing a culture bag having the retrovirus vector bound thereto, (b) adding a target cell to the culture bag that has been produced in step (a) and incubating the culture bag for 8 hours or less, and (c) flipping the culture bag upside down and incubating the culture bag. The gene introduction method is useful particularly in medicine, cell technology, gene technology, and embryologic technology. | 2014-11-27 |
20140349405 | RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS - Disclosed are components and methods for RNA-directed DNA cleavage and gene editing. The components include and the methods utilize a Cas9 protein from | 2014-11-27 |
20140349406 | Solvent Extraction Using Environmentally-Friendly Siloxane Solvents - Solvent extraction to quantify contamination of a sample by a hydrocarbon contaminant is performed by providing a defined quantity of the sample, providing a defined quantity of a siloxane solvent, mixing the defined quantity of the siloxane solvent and the defined quantity of the sample to extract the hydrocarbon contaminant from the sample to form a contaminant solution with the siloxane solvent, and separating the contaminant solution from the sample. A concentration of the hydrocarbon contaminant in the contaminant solution can be measured by vibrational spectroscopy. Siloxane solvents are CFC free, VOC exempt, odorless, colorless, low to moderately flammable, non-toxic, and safe for incidental skin contact. Some are even used in cosmetic products. | 2014-11-27 |
20140349407 | DETERIORATION ANALYZING METHOD - The present invention provides a method of deterioration analysis that enables detailed analysis of the deterioration, especially of the surface, of a polymer material containing at least two diene polymers. The present invention relates to a method of deterioration analysis including: irradiating a polymer material containing at least two diene polymers with high intensity x-rays; and measuring x-ray absorption while varying the energy of the x-rays, to analyze the deterioration of each diene polymer. | 2014-11-27 |
20140349408 | AUTOMATED STATIONARY GAS SENSOR CALIBRATION SYSTEM AND METHOD - A stationary gas monitoring and testing system includes one or more gas monitoring stations | 2014-11-27 |
20140349409 | REAGENT CARD ALIGNMENT SYSTEM AND METHOD - A reagent card analyzer comprises an optical signal source configured to transmit an optical signal and an optical signal detector spaced a distance from the optical signal source to define an optical signal path into which the optical signal is transmitted, the optical signal detector configured to detect the optical signal and to output an electrical signal indicative of the optical signal. A reader is configured to read a reagent pad of a reagent card. A reagent card moving mechanism is configured to move the reagent card having the reagent pad including a leading and trailing end through the optical signal path. An optical detector interface is electrically coupled with the optical signal detector and configured to receive electrical signals and to output a pad detect signal indicative of at least one of the leading and the trailing end as the reagent card is moved through the optical signal path. | 2014-11-27 |
20140349410 | METHOD FOR PROCESSING A FLUID AND FLUID PROCESSING DEVICE - The present invention relates to improved methods for processing fluids and to a fluid processing device ( | 2014-11-27 |
20140349411 | METHOD AND SYSTEM FOR DETECTION OF AFLATOXIN - The present invention relates to an aflatoxin-detection device. The aflatoxin-detection device includes a flow path for a test solution and a plurality of nanocompo site strips disposed within the flow path. Each nanocomposite strip of the plurality of nanocomposite strips is arranged in a spaced parallel relationship with a successive nanocomposite strip of the plurality of nanocomposite strips. The plurality of nanocomposite strips exhibit high affinity for aflatoxin. Absorption of aflatoxin induces fluorescence of the plurality of nanocomposite strips. Responsive to a fluorescence intensity of each nanocomposite strip of the plurality of nanocomposite strips, a concentration of aflatoxin in the test solution is determined. | 2014-11-27 |
20140349412 | BIOSENSOR SYSTEM FOR SINGLE PARTICLE DETECTION - A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly. | 2014-11-27 |
20140349413 | SEMICONDUCTOR DEVICES AND METHODS OF MANUFACTURING THE SAME - A method of manufacturing a semiconductor device may include forming a material layer on a substrate, performing a selective oxidation process to form a capping oxide layer on a first surface of the material layer, wherein a second surface of the material layer is not oxidized, and etching the material layer through the second surface to form a material pattern. An etch rate of the capping oxide layer is less than an etch rate of the material layer. A semiconductor device may include a lower electrode on a substrate, a data storage part on a top surface of the lower electrode, an upper electrode on the data storage part, and a capping oxide layer arranged on at least a portion of a top surface of the upper electrode. The capping oxide layer may include an oxide formed by oxidation of an upper surface of the upper electrode. | 2014-11-27 |
20140349414 | METHOD TO REDUCE MAGNETIC FILM STRESS FOR BETTER YIELD - A thin-film deposition, such as an MTJ (magnetic tunneling junction) layer, on a wafer-scale CMOS substrate, is segmented by walls or trenches and not affected by thin-film stresses due to wafer warpage or other subsequent annealing processes. An interface layer on the CMOS substrate is patterned by either undercut trenches extending into its upper surface or by T-shaped walls that extend along its upper surface. The thin-film is deposited continuously over the patterned surface, whereupon either the trenches or walls segment the deposition and serve as stress-relief mechanisms to eliminate adverse effects of processing as stresses such as those caused by wafer warpage. | 2014-11-27 |
20140349415 | PERPENDICULAR MTJ STACKS WITH MAGNETIC ANISOTROPY ENHANCING LAYER AND CRYSTALLIZATION BARRIER LAYER - Magnetic tunnel junctions (MTJ) suitable for spin transfer torque memory (STTM) devices, include perpendicular magnetic layers and one or more anisotropy enhancing layer(s) separated from a free magnetic layer by a crystallization barrier layer. In embodiments, an anisotropy enhancing layer improves perpendicular orientation of the free magnetic layer while the crystallization barrier improves tunnel magnetoresistance (TMR) ratio with better alignment of crystalline texture of the free magnetic layer with that of a tunneling layer. | 2014-11-27 |
20140349416 | METHOD FOR MANUFACTURING A MAGNETIC TUNNEL JUNCTION - The present invention relates to a magnetic tunnel junction device and a manufacturing method thereof. The magnetic tunnel junction device includes: i) a first magnetic layer including a compound having a chemical formula of (A | 2014-11-27 |
20140349417 | System, Method and Apparatus for RF Power Compensation in Plasma Etch Chamber - A system and method of applying power to a target plasma chamber include, characterizing a no plasma performance slope of the target plasma chamber, applying a selected plasma recipe to a first wafer in the target chamber, the selected plasma recipe includes a selected power set point value and monitoring a recipe factor value on the RF electrode. A ratio of process efficiency is generated comparing the reference chamber and the target chamber, the generating using as inputs the no plasma performance slopes of the target chamber and the reference chamber and the monitored recipe factor value. An adjusted power set point value is calculated, the adjusted power set point configured to cause power delivered to a plasma formed in the target chamber to match power that would be delivered to a reference plasma formed in the reference chamber. | 2014-11-27 |
20140349418 | PLASMA PROCESSING METHOD - A plasma processing method in which a stable process region can be ensured in a wide range, from low microwave power to high microwave power. The plasma processing method includes making production of plasma easy in a region in which production of plasma by continuous discharge is difficult, and plasma-processing an object to be processed, with the generated plasma, wherein the plasma is produced by pulsed discharge in which ON and OFF are repeated, radio-frequency power for producing the pulsed discharge, during an ON period, is a power to facilitate production of plasma by continuous discharge, and a duty ratio of the pulsed discharge is controlled so that an average power of the radio-frequency power per cycle is power in the region in which production of plasma by continuous discharge is difficult. | 2014-11-27 |
20140349419 | METHOD OF MANUFACTURING LIGHT-EMITTING DEVICE - A method of manufacturing a light-emitting device includes forming a wave length conversion portion on a light-emitting element. The light emitting device includes a light-emitting element which emits light of a predetermined wavelength and a wavelength conversion portion which includes a fluorescent substance which is excited by the light emitted from the light-emitting element so as to emit fluorescence of a wavelength different from the predetermined wavelength, which wavelength conversion portion is formed by including the fluorescent substance, a layered silicate mineral, and an organometallic compound. The forming the wavelength conversion portion includes forming a fluorescent substance layer on the light-emitting element using a fluorescent substance dispersion liquid including a fluorescent substance and a layered silicate mineral, applying a precursor solution including an organometallic compound on the light-emitting element, and heating the precursor solution applied on the fluorescent substance layer. | 2014-11-27 |
20140349420 | PRINTING APPARATUS AND METHOD OF FORMING AN ORGANIC LIGHT EMITTING LAYER - A printing apparatus includes a printing mask, which is disposed between a substrate having a display area and a non-display area surrounding the display area. The apparatus further includes a nozzle discharging an organic light emitting liquid onto the substrate. The printing mask includes a mask open part and a mask cover part. The mask open part exposes the display area, and the mask cover part surrounds the mask open part and covers the non-display area. The apparatus can be used to form an organic emitting layer on the substrate. | 2014-11-27 |
20140349421 | SEMICONDUCTOR LIGHT EMITTING DEVICE AND METHOD FOR MANUFACTURING THE SAME - According to one embodiment, a semiconductor light emitting device includes a structure including a first semiconductor layer of a first conductivity type, a second semiconductor layer of a second conductivity type and a light emitting layer provided between the first semiconductor layer and the second semiconductor layer. The device also includes an electrode layer provided on the second semiconductor layer side of the structure. The electrode layer includes a metal portion with a thickness of not less than 10 nanometers and not more than 100 nanometers. A plurality of openings pierces the metal portion, each of the openings having an equivalent circle diameter of not less than 10 nanometers and not more than 5 micrometers. The device includes an inorganic film providing on the metal portion and inner surfaces of the openings, the inorganic film having transmittivity with respect to light emitted from the light emitting layer. | 2014-11-27 |
20140349422 | METHOD FOR HYBRID ENCAPSULATION OF AN ORGANIC LIGHT EMITTING DIODE - Methods and apparatus for encapsulating organic light emitting diode (OLED) structures disposed on a substrate using a hybrid layer of material are provided. The processing parameters used during deposition of the hybrid layer of material allow control of the characteristics of the deposited hybrid layer. The hybrid layer may be deposited such that the layer has characteristics of an inorganic material in some sublayers of the hybrid layer and characteristics of an organic material in other sublayers of the hybrid layer. Use of the hybrid material allows OLED encapsulation using a single hard mask for the complete encapsulating process with low cost and without alignment issues present in conventional processes. | 2014-11-27 |
20140349423 | Method for Manufacturing a Liquid Crystal Display Equipment - The present invention discloses a method for manufacturing a liquid crystal display. The method includes: manufacturing a matrix substrate, having a glass layer and a metal layer; manufacturing a color filter substrate, having an active area and a black matrix region; utilizing a glue to fix the matrix substrate and the color filter substrate; and utilizing a laser point light source to make a laser generated by the laser point light source only lights up a region of the matrix substrate corresponding to the glue such that heats are transferred to the glue via the metal layer of the matrix substrate to pre-solidify the glue. The present invention only lights up the region corresponding to the glue. Therefore, the present invention does not have to use a blocking plate and reduces costs. | 2014-11-27 |
20140349424 | LEAD FRAME FOR MOUNTING LED ELEMENTS, LEAD FRAME WITH RESIN, METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICES, AND LEAD FRAME FOR MOUNTING SEMICONDUCTOR ELEMENTS - A lead frame for mounting LED elements includes a frame body region and a large number of package regions arranged in multiple rows and columns in the frame body region. The package regions each include a die pad on which an LED element is to be mounted and a lead section adjacent to the die pad, the package regions being further constructed to be interconnected via a dicing region. The die pad in one package region and the lead section in another package region upward or downward adjacent to the package region of interest are connected to each other by an inclined reinforcement piece positioned in the dicing region. | 2014-11-27 |
20140349425 | PHOTORESIST COMPOSITION, METHOD OF MANUFACTURING A POLARIZER AND METHOD OF MANUFACTURING A DISPLAY SUBSTRATE USING THE SAME - A photoresist composition includes about 65% by weight to about 80% by weight of a mono-functional monomer, about 5% by weight to about 20% by weight of a di-functional monomer, about 1% by weight to about 10% by weight of a multi-functional monomer including three or more functional groups, about 1% by weight to about 5% by weight of a photoinitiator, and less than about 1% by weight of a surfactant, each based on a total weight of the photoresist composition. | 2014-11-27 |
20140349426 | ARRAY SUBSTRATE AND METHOD OF MANUFACTURING THE SAME - An array substrate includes; a substrate, a gate line and a data line disposed on the substrate, a thin film transistor (“TFT”) electrically connected to the gate line and the data line, a light blocking member disposed on the substrate and a first color filter and a second color filter disposed on the substrate. The light blocking member covers a portion of the first color filter and the second color filter covers a portion of the light blocking member. | 2014-11-27 |
20140349427 | Enhanced Performance Active Pixel Array and Epitaxial Growth Method for Achieving the Same - Methods are described to utilize relatively low cost substrates and processing methods to achieve enhanced emissive imager pixel performance via selective epitaxial growth. An emissive imaging array is coupled with one or more patterned compound semiconductor light emitting structures grown on a second patterned and selectively grown compound semiconductor template article. The proper design and execution of the patterning and epitaxial growth steps, coupled with alignment of the epitaxial structures with the imaging array, results in enhanced performance of the emissive imager. The increased luminous flux achieved enables use of such images for high brightness display and illumination applications. | 2014-11-27 |
20140349428 | SUBSTRATE MOVING UNIT FOR DEPOSITION, DEPOSITION APPARATUS INCLUDING THE SAME, METHOD OF MANUFACTURING ORGANIC LIGHT-EMITTING DISPLAY APPARATUS BY USING THE DEPOSITION APPARATUS, AND ORGANIC LIGHT-EMITTING DISPLAY APPARATUS MANUFACTURED BY USING THE METHOD - Provided are a substrate moving unit for use with a deposition apparatus that allows a deposition material to be precisely deposited on a target site of a substrate. The substrate moving unit includes an electrostatic chuck having a first surface on which a substrate is fixable and a magnetic force applying unit disposed on a second surface of the electrostatic chuck. A deposition apparatus including the substrate moving unit, a method of manufacturing an organic light-emitting display apparatus, and an organic light-emitting display apparatus manufactured by using the method are also presented. | 2014-11-27 |
20140349429 | METHOD FOR MANUFACTURING A DISPLAY UNIT - A method for manufacturing a display unit is provided, and the method includes forming a first insulating film, forming a plurality of first electrodes on the first insulating film, forming a second insulating film on the first electrodes, forming a plurality of openings corresponding to the first electrodes, forming a plurality of organic layers formed in a shape of a stripe having notch parts, forming a second electrode on the organic layer having the notch parts is formed, and forming a protective film on the second electrode. | 2014-11-27 |