47th week of 2008 patent applcation highlights part 53 |
Patent application number | Title | Published |
20080287646 | Polyarylene and Method for Producing the Same - A dihalobenzene compound represented by the formula (1): | 2008-11-20 |
20080287647 | Polyareneazole Polymer Fibers Having Pendant Hydroxyl Groups and Cations - The present invention relates to fibers comprising polyareneazole polymer having pendant hydroxyl groups and cations. | 2008-11-20 |
20080287648 | Method for Solid Phase Peptide Synthesis - A novel method for synthesizing a Hirulog peptide is devised. | 2008-11-20 |
20080287649 | Methods for the synthesis of cyclic peptides - Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides. | 2008-11-20 |
20080287650 | High purity peptides - The invention relates to methods for the preparation of highly purified peptides. The peptides are prepared in high optical purity of at least about 98.5%, and preferably at least about 99%. Specifically, Nesiritide (SEQ. ID NO. 1) having a purity of at least 99% as measured by HPLC and containing about 0.05% to about 0.5% [D-His]-Nesiritide (SEQ. ID NO. 1) as measured by chiral GC/MS. | 2008-11-20 |
20080287651 | Silk Thread Containing Spider Thread Protein and Silk Worm Producing the Silk Thread - A transgenic silkworm having transferred therein a gene which encodes spider thread protein having desired properties of high strength and high elasticity while leaving the silkworm fibroin H chain gene intact, by means of utilizing a transposon function, is used to produce in the transgenic silkworm a spider thread protein having the desired properties without lowering the strength or elasticity of silk thread produced by the transgenic silkworm, thereby providing hybrid silk of spider and silk threads having the desired properties. | 2008-11-20 |
20080287652 | Antagonists Against Interaction of Pf4 and Rantes - The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment. | 2008-11-20 |
20080287653 | METHOD FOR PRODUCING INHIBITORS AND INHIBITORS FORMED THEREFROM - The present invention relates to methods for producing inhibitors for protein deacetylases, and to the compounds and/or products produced by such methods. More specifically, the present invention relates to methods for producing inhibitors for human class III protein deacetylases or sirtuins, and to the compounds and/or products produced by such methods. The present invention provides the transformation of peptide substrates to potent peptide inhibitors by replacement of N | 2008-11-20 |
20080287654 | PEPTIDE MEDIATED SYNTHESIS OF METALLIC AND MAGNETIC MATERIALS - The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material. | 2008-11-20 |
20080287655 | Method of producing s-nitrosoprotein preparation - A protein is efficiently nitrosylated with nitrogen monoxide by merely mixing S-nitrosoglutathione as a nitrogen monoxide donor with a protein solution containing a stabilizing agent comprising at least one compound or a combination of plural compounds selected from an N-acetylamino acid, a fatty acid, and a fatty acid salt. The method that enables efficient NO addition to a cysteine residue in un-nitrosylated protein without changing the structure of protein and hence provides NO to a living organism. | 2008-11-20 |
20080287656 | Device and Method For Cell Free Analytical and Preparative Protein Synthesis - A device is disclosed which contains one or more pores | 2008-11-20 |
20080287657 | Alteration of Fc-fusion protein serum half-lives by mutagenesis - The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified Fc-fusion protein, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified Fc-fusion protein. | 2008-11-20 |
20080287658 | Docetaxel Immunoassay - Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in biological fluids. | 2008-11-20 |
20080287659 | G-CSF Conjugates - Physiologically active PEG-GCSF conjugates having a formula as follows: | 2008-11-20 |
20080287660 | Novel OrfF and OrfF' polypeptides, nucleic acid molecules encoding the polypeptides and applications thereof - The invention relates to novel pathogenic OrfF and OrfF′ polypeptides derived from | 2008-11-20 |
20080287661 | Devices and methods for reducing matrix effects - Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means is a size exclusion filter or a polymeric or inorganic monolith having a maximum pore size less than or equal to the diameter of the particles to be removed from the sample, and can be integral with the sorbent or associated with the sorbent. The sorbent is characterized by sufficient selectivity between the matrix interfering agents and analytes of interest to provide retention of the matrix interfering agents while providing elution of the analytes of interest (e.g., a reversed phase or a polar modified reversed phase). Typical devices incorporating these features include luer syringe filters, individual filter cartridges, multiwell plates, pipette tips, or inline columns for multiple or single use. | 2008-11-20 |
20080287662 | Balanites Aegyptiaca Saponins and Uses Thereof - The invention relates to stable preparations of saponin nanovesicles, which can encapsulate active biological or chemical materials such as drugs, pesticides, vitamins, minerals and nutrients, and protect them. The preparations can be used, for example, in agricultural, pesticidal, dermatological and cosmetic compositions. The saponins per se can further be used as adjuvants for irrigation water. The invention further relates to novel saponins extracted from | 2008-11-20 |
20080287663 | Process For Production Of 4-Biphenylyazetidin-2-Ones - The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula | 2008-11-20 |
20080287664 | HSP60 FROM ARTHROBACTER - The hsp60 gene from a strain of | 2008-11-20 |
20080287665 | CANINE IgG NUCLEIC ACID MOLECULES - The invention relates to canine immunoglobulin G (IgG) and canine interleukin-13 receptors (IL-13R) as well as fusion proteins containing canine IgG and/or canine IL-13R. In particular, the present invention discloses nucleic acid molecules encoding canine IgG, including species-specific regions of the heavy chain of canine IgG, and canine IL-13R alpha chain (IL-13Rα) proteins, particularly canine interleuken receptor alpha 1 (IL-13Rα1) and canine interleuken receptor alpha 2 (IL-13Rα2) proteins. Also included are canine IgG and IL-13Rα proteins, antibodies having selectivity for such proteins, inhibitors of such proteins and/or nucleic acid molecules, cells transformed with said nucleic acid molecules, assays employing such cells, nucleic acids molecules, proteins, antibodies and/or inhibitors, and therapeutic compositions comprising said nucleic acids molecules, proteins, antibodies and/or inhibitors. Also included are kits containing said molecules or chimera thereof, including their use to evaluate and regulate an immune response in an animal. | 2008-11-20 |
20080287666 | DETECTING NUCLEIC ACID STRANDS AND INTER-SUBSTANCE BINDING OR INTERACTION DETECTING METHOD - Disclosed herein is a detecting nucleic acid strand including: a first nucleic acid strand having a first base sequence region capable of functioning as an aptamer, and a second nucleic acid strand having a second base sequence region, which is complementary to the first base sequence region and forms a complementary strand with the first base sequence region, wherein the detecting nucleic acid strand is designed such that, when a predetermined substance interacts with the first base sequence region, the complementary strand of the first and second base sequence regions dissociates into single strands. | 2008-11-20 |
20080287667 | Nucleic Acid Labeling Compounds - Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofaranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection. | 2008-11-20 |
20080287668 | Nanostructures and methods of making - A nanostructure can include a first single-stranded nucleic acid, a plurality of complementary single-stranded helper nucleic acids hybridized with the first single-stranded nucleic acid, and at least one nanocube linked to a helper nucleic acid by a tether. The nanostructure can include at least two nanocubes each linked to a helper nucleic acid by a tether, and bonded to each other. | 2008-11-20 |
20080287669 | METHODS AND COMPOSITIONS FOR IDENTIFYING COMPOUNDS USEFUL IN NUCLEIC ACID PURIFICATION - The present invention provides methods, compositions, and kits for identifying compounds useful in nucleic acid purification. The methods of the invention include identifying certain characteristics of organic solvents such as miscibility in water, dielectric constant, and the class of the solvent. | 2008-11-20 |
20080287670 | Systems and methods for the purification of synthetic trityl-on oligonucleotides - Chromatographic loading solutions for use in the purification of trityl-on oligonucleotides. The solutions comprise an antichaotropic ion, a chaotropic ion, an alkaline salt, and a polar protic solvent, all at particular concentrations. The solution is useful in purifying oligodeoxyribonucleotides and oligoribonucleotides having either ACE or TBDMS protective caps. Also, methods and systems for purifying trityl-on oligonucleotides comprising the chromatographic loading solution, a reversed-phase sorbent, and the oligonucleotides to be purified. | 2008-11-20 |
20080287671 | DRUG-ELUTING STENTS COATED WITH P2Y12 RECEPTOR ANTAGONIST COMPOUND - The present invention provides a P2Y | 2008-11-20 |
20080287672 | Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods - The invention provides a composition containing hyaluronic acid (HA) or a pharmaceutically-acceptable salt thereof preserved with a cationic preservative and related methods. In one embodiment, the pharmaceutically-acceptable salt is sodium hyaluronate. In another embodiment, the cationic preservative includes benzalkonium chloride (BAK). | 2008-11-20 |
20080287673 | CEFDINIR PROCESS - The present invention provides an improved process for the preparation of high assayed cefdinir. Thus, crude cefdinir is added to water at 25-30° C. and then 18% hydrochloric acid is slowly added to form a clear solution. The solution is cooled to −5° C. and stirred for 5 minutes at −5° C. to +5° C. Then temperature of the mass is raised to 35-38° C., stirred for 15 minutes at the same temperature. To the reaction mass eno carbon is added at 35-38° C. and stirred for 30 minutes at 35-38° C. Then the contents are filtered on hiflo bed and washed with water. The filtrate is then cooled to 25° C., the pH is slowly adjusted to 2.6 with saturated sodium bicarbonate solution and stirred for 60 minutes at 25-30° C. Filtered the solid, washed with water and dried at 40° C. under vacuum to give high assayed cefdinir. | 2008-11-20 |
20080287674 | Inhibitors of Factor XA and Other Serine Proteases Involved in the Coagulation Cascade - Compounds useful as intermediates for synthesis of compounds of Formula (I): | 2008-11-20 |
20080287675 | CASCADE SYSTEM - A method of purifying an active pharmaceutical ingredient sufficient for administration into a human subject can include: obtaining a reaction product composition having the active pharmaceutical ingredient and impurities, wherein said active pharmaceutical ingredient is rapamycin or a rapamycin analog; introducing the reaction product composition into a first column of a chromatography system; directing a first portion of a first elutant from the first column to waste, said first portion having more impurity than active pharmaceutical ingredient; directing a second portion of the first elutant from the first column into a second column, said second portion having more active pharmaceutical ingredient than impurity; collecting factions of a second elutant from the second column that include the active pharmaceutical ingredient; and concentrating the said collected fractions to obtain a purity of the active pharmaceutical ingredient greater than 98% and with less than or about 0.95% being first and second major impurities. | 2008-11-20 |
20080287676 | FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR - The present invention discloses novel compounds of general formula (I) | 2008-11-20 |
20080287677 | Salts of Aripiprazole - The present invention relates to acid addition salts of aripiprazole, a process for preparing said acid addition salts and their use to prepare or purify aripiprazole in the form of a free base or in the form of a pharmaceutically acceptable salt. | 2008-11-20 |
20080287678 | Multiple Chromophores Based on Rylene - A rylene-based polychromophore of the general formula I | 2008-11-20 |
20080287679 | Process for preparing clopidogrel - The present invention encompasses processes for the preparation of optically pure clopidogrel camphorsulfonic acid salt without the need to isolate or recover (±) clopidogrel. | 2008-11-20 |
20080287680 | Solifenacin Succinate-Containing Composition - A solifenacin succinate-containing composition with less impurities which can be used as a bulk for pharmaceutical is provided. | 2008-11-20 |
20080287681 | Substituted Benzimidazoles and their Use for Inducing Apoptosis - The invention relates to compounds of formula (I) | 2008-11-20 |
20080287682 | Substituted benzimidazoles and methods of preparation - Methods for preparing new substituted benzimidazole compounds having formula (I) useful for treating kinase mediated disorders are provided wherein R | 2008-11-20 |
20080287683 | PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES - The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to novel compounds of 3,4-disubstituted-thiazolidin-2-ones. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds (such as latrunculins and/or their analogs) for treating diseases or conditions associated with inhibiting actin polymerization. | 2008-11-20 |
20080287684 | Method for Producing Ionic Liquids - The present invention describes a process for preparing ionic liquids (I) by reacting ionic liquids (II) whose anion is a halide with an acid (III), with the resulting hydrogen halide being scavenged by means of an amine and the resulting ammonium halide being able to be separated off. | 2008-11-20 |
20080287685 | Detomidine Hydrochloride Crystallization Method - A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with | 2008-11-20 |
20080287686 | Process for Preparing Onium Salts - An 'onium salt, e.g. a quaternary ammonium salt, of an anionic dye maybe prepared by mixing an aqueous solution of a salt of the dye with a solution of a water-insoluble 'onium salt in an organic solvent, and separating a solution of the 'onium salt of the anionic dye in the organic solvent from the residual aqueous solution. | 2008-11-20 |
20080287687 | Production method of diphenylalanine-Ni (II) complex - The present invention relates to a production method of a compound represented by the formula (3), which includes reacting a compound represented by the formula (2) with a diphenylmethyl halide compound represented by the formula (1) in the presence of alkali metal alkoxide. According to the method of the present invention, compound (3) can be produced at a high purity and in a high yield. | 2008-11-20 |
20080287688 | Efficient Process For Production Of Carvedilol Phosphate - A novel cost effective process for the synthesis of phosphate salts of 1-(9H-carbazol-4yloxy)-3-[[2-(2-methoxyphenoxy)ethyl] amino]-propan-2-ol, (carvedilol phosphate) of formula (II) with high yields and purity is disclosed. More particularly, the invention discloses a process for preparation of crystalline phosphate salts of carvedilol using various phosphate forming reagents such as phosphorous pentoxide, polyphosphoric acid, dipotassium hydrogen phosphate, ammonium dihydrogen ortho phosphate, and sodium dihydrogen ortho phosphate in solvents selected from Acetonitrile, acetone and tetrahydrofuran. The solvents used to prepare solvates of carvedilol dihydrogen phosphate are methanol, ethanol and isopropyl alcohol. | 2008-11-20 |
20080287689 | Heat-stable diketopyrrolopyrrole pigment mixtures - The present invention relates to a process for the preparation of a mixture comprising at least two structurally different diketopyrrolopyrrole pigments of formula | 2008-11-20 |
20080287690 | Process For (3R, 5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4- [(4-Hydroxy Methyl Phenyl Amino) Carbonyl]-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid Hemi Calcium Salt - The present invention relates to processes for the manufacture of (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt. | 2008-11-20 |
20080287691 | Polymorphic form of atorvastatin calcium - The present invention relates to atorvastatin calcium, a useful agent for lowering serum cholesterol levels. New atorvastatin calcium Form V, processes for preparing the new form, and pharmaceutical compositions and dosage forms containing the new form are disclosed. | 2008-11-20 |
20080287692 | Synthesis of cyclopentadiene derivatives - A compound of formula (X): | 2008-11-20 |
20080287693 | Process for the Preparation of 1-Naphthol Mixed Ethers and Intermediates of Crystalline Forms of (+) and (-)-Duloxetine - The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed. | 2008-11-20 |
20080287694 | PROCESSES FOR PRODUCING A FLUOROSULFONYL GROUP-CONTAINING COMPOUND AND A COMPOUND LED FROM THE FLUOROSULFONYL GROUP-CONTAINING COMPOUND - A fluorosulfonyl group-containing compound having a high polymerization reactivity, a process for its production, a sulfonyl group-containing polymerizable monomer led from the sulfonyl group-containing compound, and a polymer obtainable by polymerizing the sulfonyl group-containing polymerizable monomer, are provided. | 2008-11-20 |
20080287695 | Agent For Optical Resolution, Process For Producing Optically Active Substance and 1,5-Substituted Bicyclo [3.3.0] -2-Oxaoctane Compound - An agent for optical resolution comprising a bicyclo[3.3.0]-2-oxaoctane compound represented by the formula [1], [2] or [3] a process for producing an optically active substance comprising obtaining a mixture of diastereomers by reaction of the agent with a mixture of optically active substances having active hydrogen atom, resolving the mixture of diastereomers into each diastereomer and obtaining an (R) optically active substance or an (S) optically active substance by decomposition of the diastereomer; and compounds represented by the above formulae in which R | 2008-11-20 |
20080287696 | Process for the Preparation of Synthetic Taxanes - The present invention relates to a process for the preparation of synthetic taxanes, which protects C(7)-OH with lanthanon compounds. Its advantages are simple process and firm & reliable binding. Moreover, no C(7)-acylated taxanes are produced in the subsequent steps, and hydrolysis of C(2′)-ester groups in acylated products becomes readily controllable. In the process for the preparation of synthetic taxanes, tetrahydrofuran is used in the present invention as a medium for acylation, which not only achieves the same effects as pyridine, but also avoids odor, so as to solve the problem regarding the extremely high requirements for the place of production. The present invention can be used for the preparation of not only semi-synthetic taxane using natural taxanes as raw material, but also full-synthetic taxane. | 2008-11-20 |
20080287697 | Process for preparing fatty acid esters from pre-treated glyceride oils - This invention provides a process for forming fatty acid esters of C | 2008-11-20 |
20080287698 | Ferrocenyl Ligands For Homogeneous, Enantioselective Hydrogenation Catalysts - Compounds of the formula (I) or (I′), where R | 2008-11-20 |
20080287699 | Process for Hydrosilylation - Compounds containing unsaturated carbon-carbon bonds are hydrosilylated with H-silanes or H-siloxanes in the presence of a noble metal catalyst, wherein the water content of the reaction mixture is less than 500 ppm and the noble metal catalyst is supplied as a liquid, and is present in an amount of not more than 50 ppm. | 2008-11-20 |
20080287700 | Method for Preparing an Omega-Haloalkyl Dialkylhalosilane - The present invention relates to a method for preparing an omega-haloalkyl dialkylhalosilane by means of a hydrosilylation reaction in the presence of a catalytically effective amount of a hydrosilylation catalyst containing a platinum group metal. The catalytic metal is recovered by (i) subjecting the distillation residue to controlled hydrolysis to release the gaseous H-Hal haloacid, and providing an aqueous medium containing the catalytic metal with a low hydrolysable halide content Si-Hal=2%, expressed by weight of Hal, then (2i) recovering the platinum group catalytic metal from said aqueous medium by means of one of the conventional techniques specific to catalyst manufacturers that do not use a solid adsorbent and operate in ordinary facilities that do not have to be acid-resistant. | 2008-11-20 |
20080287701 | BISBIPHENYLACYLPHOSPHINE OXIDE AND PREPARATION METHOD THEREFORE - A bisbiphenylacylphosphine oxide of formula (I) and its preparation method are provided. The formula of —Ar— is | 2008-11-20 |
20080287702 | Novel intermediates, process for their preparation and synthesis of 1, 4-benzoquiones - The present invention discloses a new process for the preparation of 1,4-benzoquiones of formula (II) | 2008-11-20 |
20080287703 | LAYERED COMPOSITION AND PROCESSES FOR PREPARING AND USING THE COMPOSITION - A layered composition which can be used in various processes has been developed. The composition comprises an inner core such as a cordierite core and an outer layer comprising a refractory inorganic oxide, a fibrous component and an inorganic binder. The refractory inorganic oxide layer can be alumina, zirconia, titania, etc. while the fibrous component can be titania fibers, silica fibers, carbon fibers, etc. The inorganic oxide binder can be alumina, silica, zirconia, etc. The layer can also contain catalytic metals such as gold and platinum plus other modifiers. The layered composition is prepared by coating the inner core with a slurry comprising the refractory inorganic oxide, fibrous component, an inorganic binder precursor and an organic binding agent such as polyvinyl alcohol. The composition can be used in various hydrocarbon conversion processes including production of vinyl acetate. | 2008-11-20 |
20080287704 | PREPARATIVE-SCALE SEPARATION OF ENANTIOMERS OF CHIRAL CARBOXYLIC ACIDS - High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity. | 2008-11-20 |
20080287705 | METHOD OF PRODUCING ETHYNYL COMPOUND, METHOD OF HANDLING ETHYNYL COMPOUND, AND METHOD OF USING ASCORBIC ACID OR SALT THEREOF - A method of producing a first ethynyl compound represented by the following formula (1), the method including reacting a second ethynyl compound represented by the following formula (2) in a liquid phase in the presence of a reducing agent to obtain the first ethynyl compound, wherein Q | 2008-11-20 |
20080287706 | Method and apparatus for making acetic acid with improved light ends column productivity - An improved apparatus and method of producing acetic acid includes condensing overhead vapor to provide reflux to the light ends column as well as condensing vapor from a central portion of the light ends column to increase capacity. Throughput or load on the light ends column is substantially reduced without compromising product quality. | 2008-11-20 |
20080287707 | Adsorption Of Volatile Organic Compounds Derived From Organic Matter - A method for adsorbing volatile organic compounds (VOCs) derived from organic matter comprises adsorbing the VOCs onto palladium doped ZSM-5, optionally at ambient temperature. The organic matter can be perishable organic goods such as food, including fruit and/or vegetables, horticultural produce, including plants and/or cut flowers, or refuse. The palladium doped ZSM-5 has a Si:Al ratio of less than or equal to 100:1 and preferably has a palladium content of from 0.1 wt % to 10.0 wt % based on the total weight of the doped ZSM-5. | 2008-11-20 |
20080287708 | STABLE BORANE REAGENTS AND METHODS FOR THEIR USE - The invention provides methods for storing boranes (e.g. B-allyldiisopinocampheylborane). The invention also provides stable compositions comprising boranes, as well as methods for carrying out allylboration at high temperature and/or in the presence of water. | 2008-11-20 |
20080287709 | Method of Separating Acids from Chemical Reaction Mixtures by Means of Apolar Amines - A process for the removal of acids from reaction mixtures, comprising at least one product of value which is sparingly soluble in water, by at least one unpolar amine as an auxiliary base, which includes: a) reacting the auxiliary base with the acid with formation of a salt; b) reacting the salt formed in step a) with a further base which accepts the acid with liberation of the auxiliary base and combines with the acid to be accepted from the auxiliary base to form a salt which is very readily soluble in water; c) extraction of the mixture obtained in step b) with water or an aqueous medium, wherein the salt of the further base dissolves in the aqueous phase and the product of value, or the solution of the product of value, in a suitable solvent and the auxiliary base form at least one separate nonaqueous phase; and d) removal by distillation of at least part of any solvent present from the at least one nonaqueous phase obtained in step c), to form two nonmiscible liquid phases. | 2008-11-20 |
20080287710 | Methods for the preparation of chemically misaminoacylated tRNA via protective groups - The present invention relates to methods for the preparation of chemically aminoacylated tRNAs for the purpose of introduction of markers into nascent proteins. The present invention also relates to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system utilizing chemically aminoacylated tRNAs. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. | 2008-11-20 |
20080287711 | Purification of Iodixanol - A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising ethanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”). | 2008-11-20 |
20080287712 | Production Method of Trihydrocarbylborane - The present invention provides a method for industrial production of trihydrocarbylborane which method is excellent both in quality and in cost. The present invention is concerned with production of trihydrocarbylborane, comprising a reaction synthesizing the trihydrocarbylborane and aluminum oxide from trihydrocarbylboroxine and trihydrocarbylaluminum, characterized in that the reaction is allowed to proceed so that the trihydrocarbylaluminum is present at the end of the reaction in an amount of 0.5 moles or more per mole of the aluminum oxide produced in the reaction. | 2008-11-20 |
20080287713 | Halophospholanes And Their Preparation - The present invention is directed to a process for preparing compounds of the general formula (I). Compounds of the general formula (I) are advantageous precursors for preparing phospholane catalysts, especially bisphospholane catalysts. The invention therefore likewise provides for the use of the substances in question for preparing these catalysts. | 2008-11-20 |
20080287714 | Industrial Process for Acetals Production in a Simulated Moving Bed Reactor - The present invention is an industrial process for the preparation of acetals using a simulated moving bed (SMB) reactor system to accomplish the conversion of reactants (aldehyde and alcohol) and simultaneously, the separation of the reaction products (acetal and water) by selective adsorption. The SMB reactor consists of a set of interconnected columns packed with an acid solid (or mixture of acid solids: catalysts and adsorbents) effective for catalyzing the reaction between aldehydes and alcohols and for separating the reaction products by selective adsorption of at least one product. In a general embodiment, this process involves (1) feeding a mixture of aldehydes and alcohols and a desorbent which is the alcohol, to a simulated moving bed reactor; (2) reacting aldehydes and alcohols to form acetals; and (3) removing from the simulated moving bed reactor two liquid streams, a first liquid stream comprising a solution of acetal in the desorbent (raffinate), a second liquid stream comprising the water formed and the desorbent (extract). | 2008-11-20 |
20080287715 | POLYMERIZATION INHIBITOR FOR TETRAFLUOROETHYLENE - The present invention provides a polymerization inhibitor preventing the self-polymerization of TFE and the generation of a modified polymer of a polymerization inhibitor in a distillation step, particularly in a rectification step, of TFE. The present invention provides a method of distilling tetrafluoroethylene in the presence of a polymerization inhibitor comprising a cyclohexadiene compound of the formula: | 2008-11-20 |
20080287716 | Process For The Preparation Of Chloromethane Using Recycled Hydrogen Chloride - The invention relates to a process for the preparation of chloromethane from methanol and hydrogen chloride contaminated with Si compounds, the Si compounds being methylchlorosilanes, methoxymethylsilanes and hydrolysis and condensation products thereof, in which some of the Si compounds are removed by condensation from the chloromethane formed and remaining Si compounds are washed out with methanol, the methanol thus obtained and containing Si compounds being used for the further preparation of chloromethane with hydrogen chloride. | 2008-11-20 |
20080287717 | Feedstock preparation of olefins for oligomerization to produce fuels - A feedstock containing at least 1 wt % butenes, at least 1 wt % pentenes, at least 1 wt % hexenes, at least 10 wppm C | 2008-11-20 |
20080287718 | Catalytically Active Porous Membrane Reactor for Reacting Organic Compounds - The invention relates to a catalytically active membrane pore flow reactor, to the membrane used and to processes using this reactor. | 2008-11-20 |
20080287719 | Process for para-xylene production from light aliphatics - The subject process obtains a high yield of high-purity para-xylene from a butene dimer feed. The process may include dimerization of isobutene to obtain a butene dimer comprising C | 2008-11-20 |
20080287720 | Alkylaromatics Production - A process for alkylation of an alkylatable aromatic compound to produce a monoalkylated aromatic compound, comprising the steps of: (a) providing at least one reaction zone having a water content with at least one alkylation catalyst having an activity and a selectivity for said monoalkylated benzene, said alkylation catalyst comprising a porous crystalline molecular sieve of a MCM-22 family material, said MCM-22 family material is characterized by having an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25, 3.57±0.07 and 3.42±0.07 Angstroms; (b) supplying the reaction zone with at least one alkylatable aromatic compound and at least one alkylating agent; (c) operating the reaction zone under suitable alkylation or transalkylation conditions, to produce at least one effluent which comprises a monoalkylated aromatic compound and a polyalkylated aromatic compound(s); (d) monitoring the amount of the monoalkylated aromatic compound or the amount of the polyalkylated aromatic compound(s) in the effluent; (e) adjusting the water content in the reaction zone to secure a desired amount of the monalkylated aromatic compound or the polyalkylated aromatic compound(s) in the effluent, the water content in the reaction zone being in a range from about 1 wppm to about 900 wppm; and wherein the polyalkylated aromatic compound(s) produced is reduced as compared to the reaction zone having a water content of about 0 wppm when the reaction zone is operated under equivalent conditions. | 2008-11-20 |
20080287721 | CATALYSTS FOR OLEFIN POLYMERIZATION - This invention relates to the field of olefin polymerization catalyst compositions, and methods for the polymerization and copolymerization of olefins, typically using a supported catalyst composition. In one aspect, this invention encompasses precontacting a metallocene with a borinic acid or boronic acid prior to contacting this mixture with the acidic activator-support and an organoaluminum compound. | 2008-11-20 |
20080287722 | Method for Dehydrating Fatty Alcohols - A process for the production of hydrocarbons by dehydrating primary alcohols with a dehydration catalyst of trifluoromethansulfonic acid is disclosed. The hydrocarbons so produced have fewer undesired secondary reactions. Accordingly, cosmetic and cleaning compositions incorporating the hydrocarbons produced by way of the process are also disclosed. | 2008-11-20 |
20080287723 | Isomerization of Benzene-Containing Feedstocks - The benzene content in a gasoline pool is reduced by a process that hydrogenates a benzene-containing isomerization zone feedstream. The additional cyclic hydrocarbons produced by the saturation of benzene can be processed in the isomerization zone for ring opening to increase the available paraffinic feedstock or the isomerization zone can be operated to pass the cyclic hydrocarbons through to a product recovery section. The isomerization zone feedstream is treated to remove contaminants and dried before entering the hydrogenation zone. | 2008-11-20 |
20080287724 | Isomerization of Benzene-Containing Feedstocks - The benzene content in a gasoline pool is reduced by a process that hydrogenates a benzene-containing isomerization zone feedstream. The additional cyclic hydrocarbons produced by the saturation of benzene can be processed in the isomerization zone for ring opening to increase the available paraffinic feedstock or the isomerization zone can be operated to pass the cyclic hydrocarbons through to a product recovery section. The isomerization zone feedstream is treated to remove contaminants and dried before entering the hydrogenation zone. | 2008-11-20 |
20080287725 | Fulvene purification - The present invention provides a method of removing undesired isomers, including substituted cyclopentadiene regioisomers, from the desired fulvene in a crude fulvene composition by selectively reacting the undesired isomers with pyrrolidine and 4-(N,N-dimethylamino)benzaldehyde. This reaction converts the undesired substituted cyclopentadienes into fulvene-type compounds that is readily separated from the desired fulvene. | 2008-11-20 |
20080287726 | Optimised Method For The Bulk Storage and Transport of Natural Gas - This invention relates to the pressurized and chilled containment of natural gas contained within a liquid state of light hydrocarbon matrix mixture. It specifically yields the optimal storage net-density of natural gas within a propane-based solvent that is possible to attain, relative to that of Compressed Natural Gas under identical storage conditions. It further outlines how such mixtures can be advantageously handled for the bulk transport of natural gas. | 2008-11-20 |
20080287727 | CATALYST FOR REFORMING HYDROCARBON AND METHOD FOR PREPARATION THEREOF, AND PROCESS FOR REFORMING HYDROCARBON USING SAID CATALYST - The present invention relates to a catalyst for reforming a hydrocarbon comprising a carrier containing manganese oxide and carried thereon (a) at least one component selected from a ruthenium component, a platinum component, a rhodium component, a palladium component, an iridium component and a nickel component and a process for producing the same and to a process for reforming a hydrocarbon (steam reforming, self thermal reforming, partial oxidation reforming and carbon dioxide reforming) using the above catalyst. Provided are a catalyst for reforming a hydrocarbon which comprises ruthenium, platinum, rhodium, palladium, iridium or nickel as an active component and in which a reforming activity is elevated, a process for producing the same, and a steam reforming process, a self thermal reforming process, a partial oxidation reforming process and a carbon dioxide reforming process for a hydrocarbon using the above catalyst. | 2008-11-20 |
20080287728 | MARKER SYSTEMS AND METHODS OF USING THE SAME - A marker system includes a structure having a first surface and a second surface, a first marker located on the first surface, and a second marker located on the second surface, wherein the first marker and the second marker are arranged so that they face approximately a same direction, and so that they can be simultaneously viewed by an optical device, and wherein a first distance between the first marker and the optical device is different from a second distance between the second marker and the optical device when the first and the second markers are simultaneously viewed by the optical device. | 2008-11-20 |
20080287729 | INTERSTITIAL MARKER AND METHOD FOR CREATION THEREOF - An interstitial marker for localization of organs, biopsy sites, tumors or tumor beds, is comprised of a fluid marker material which is visible under at least one imaging modality. The fluid marker material is injected at the desired location to create a marker having a desired size and configuration. The configuration includes combinations of straight and curved lines, spheres and blank spaces. The fluid marker material includes a high density metal such as bismuth, gold, or iridium suspended in a liquid, in colloidal form or made into a solution. | 2008-11-20 |
20080287730 | Apparatus for Creating Therapeutic Charge Transfer in Tissue - An apparatus for creating therapeutic charge transfer in tissue includes a coil. The coil generates a changing magnetic field to induct an electric field in the tissue exceeding 10 mV/cm when the coil is 5 cm from the tissue. Preferably, the magnetic field has a growth phase and a decay phase and a duration of the growth phase is at least ten times a duration of the decay phase. The apparatus can include a control circuit to control a current fed to the coil. The control circuit includes two subcircuits and a switch for switching between a first of the subcircuits and a second of the subcircuits; preferably, a λ of the second subcircuit is at least ten times a λ of the first subcircuit. To generate the therapeutic effect, the coil should have a duty cycle of at least ten percent. | 2008-11-20 |
20080287731 | NEEDLE INSTRUMENTS AND IMPLANTABLE SLING ASSEMBLY; KITS COMPRISING THESE COMPONENTS; AND METHODS FOR USE - A sling assembly for implantation in a patient to support an internal physiological structure is provided. The sling assembly includes a length of porous material having a generally longitudinal flat surface and tubular sleeves associated with each end of the porous material, each of the sleeves having an inner passage sized and configured to provide frictional sliding over outer surfaces of an insertion instrument. The sleeves may have multiple slots for passage of insertion instruments, and the sling assembly may be mounted on insertion instruments having various configurations. In general, the sleeve is mounted on a curved needle portion of an insertion instrument by passage of the needle portion through a slot in the sleeve. | 2008-11-20 |
20080287732 | NEEDLE INSTRUMENTS AND IMPLANTABLE SLING ASSEMBLY; KITS COMPRISING THESE COMPONENTS; AND METHODS FOR USE - Kits and methods for implanting slings and other implantable materials for repair, reconstruction and repositioning of internal anatomical structures are provided. The kit comprises multiple different curved needle insertion instruments and a sling assembly that is mountable on multiple configurations of insertion instruments, permitting the medical professional to choose appropriate instruments and combinations for carrying out different interventional procedures for placement of the sling assembly. Methods for implanting the sling assembly involve advancing a needle portion of an insertion instrument through at least one of the tubular sleeves attached to the sling assembly until a distal end of the needle protrudes from a distal end of the sleeve; inserting one or both ends of the sling into a patient at a desired location using the insertion instrument; manipulating the insertion instrument to place the sling in a position that supports the internal physiological structure; removing the insertion instrument and the sleeves attached to the sling assembly from the patient; and separating the sling from the sleeves and the insertion instrument, leaving the sling supporting the internal anatomical structure. | 2008-11-20 |
20080287734 | System and methods for clearance of obstructions - The present invention is a system and methods to clear obstructions including foreign objects and food boluses during an EGD procedure. The medical device according to the present invention includes a flexible tubular housing, power transfer device, clamp, tool element, power source, and optional hood. The present invention drills through the obstruction to rupture it into pieces. Displaced obstructions, and/or pieces thereof, can be collected within the housing. The remainder of the obstruction can then be passed into the stomach where it can be digested, safely excreted, or actively removed by an endoscopist. | 2008-11-20 |
20080287735 | MEDICAL TREATMENT ENDOSCOPE - A medical treatment endoscope according to the present invention is provided with: a flexible sheath capable of a bending operation; an arm section protruding from the tip of the sheath and capable of a bending operation; an operation stick formed to allow a procedure instrument to pass therethrough so that the operation stick is operated by an operator in an attempt to bend the arm section; and a channel unit having a first channel which allows the procedure instrument to pass therethrough so that the channel unit is inserted through the operation stick detachably. | 2008-11-20 |
20080287736 | BENDING DEVICE FOR ENDOSCOPE - An operating wire is inserted in a close-contact coil in a bendable tube portion through a flexible tube portion. The close-contact coil is such that a fixed portion is provided at the position of a bending piece which is placed at the most base end of the bendable tube portion, and that a close-contact coil extension portion having been put in a non-fixed state extends from the fixed portion in the bendable tube portion. A part between a fixed portion and the fixed portion of the close-contact coil is a remote control cable for transmitting an amount of pushing and pulling an operating wire when operating an operating wire. A close-contact coil extension portion extended from the fixed portion at the side of a tip end of the close-contact coil functions as a positioning guide section for holding the operating wire so as to prevent the operating wire from being displaced in a circumferential direction. | 2008-11-20 |
20080287737 | MEDICAL TREATMENT ENDOSCOPE - A medical treatment endoscope includes: a flexible sheath capable of a bending operation; a viewing unit for observing the vicinity of the tip relative to the sheath; an arm section protruding from the tip of the sheath and capable of bending operation; an operation section for operating the arm section; and at least a transmission member, connected to the arm section and the operation section, for transmitting the operation of the operation section to the arm section. The transmission member is detachably connected to the operation section. | 2008-11-20 |
20080287738 | MOTOR-DRIVEN BENDING ENDOSCOPE - A motor-driven bending endoscope includes a removal restriction mechanism which restricts removal of a trackball from a trackball mounting portion, and an operation section engaging portion which detachably engages an attachment/detachment portion with an operation section attachment portion at a time of coupling between the operation section attachment portion and the attachment/detachment portion when an operation section unit is attached to the operation section attachment portion. The operation section engaging portion and the removal restriction mechanism are interlockingly driven by an interlock drive mechanism. Thereby, there is provided a motor-driven bending endoscope which can reduce fatigue of the right hand at a time of performing a twisting operation of an insertion section, improve the recognizability of the up-and-down direction at a time of inserting the insertion section, and enhance the operational work efficiency. | 2008-11-20 |
20080287739 | Torque-Transmitting, Locking Instrument Holder and Method for Operating the Instrument Holder - A torque-transmitting, locking instrument holder, includes a hollow body having a proximal end for receiving an instrument, a distal end for protrusion of the instrument, and a handle to be gripped by an operator. A device is provided for locking the handle to and unlocking the handle from the instrument at least partly disposed within the hollow body. A method for operating the instrument holder includes providing a hollow body having a proximal end for receiving an instrument, a distal end for protrusion of the instrument, and a handle to be gripped by an operator. The instrument is placed at least partly within the hollow body and the handle is locked to and unlocked from the instrument. | 2008-11-20 |
20080287740 | METHODS AND DEVICES FOR TRAVERSING AN ANATOMIC WALL - Disclosed herein are various systems and methods for traversing an anatomic wall. A system can include a port that mates with an anatomic wall and provides a lumen for the passage of a guide tube of a transluminal device. The port can inhibit the passage of biological materials through the anatomic wall. Further described herein are methods for implanting the port and/or for inserting the transluminal device into a body cavity. | 2008-11-20 |
20080287741 | ARTICULATING TORQUEABLE HOLLOW DEVICE - An articulating mechanism for use in a medical device, such as an endoscope or a catheter, includes a series of stacked links disposed adjacent to one another and movable with respect to each other. Each link includes a front face tapered to a pair of pivot points and a rear face defining a wedge shaped recess for receiving the pivot points of the adjacent link. Pull-wires provide tension and hold the staked links together while also allowing for controlled bending of the distal portion by movement of one or more of the pull-wires. | 2008-11-20 |
20080287742 | LIGHT SOURCE POWER BASED ON PREDETERMINED SENSED CONDITION - A medical instrument having a lighting system for illuminating a target area, the system comprising a light source and associated power controller, the system being configured to move from a first illumination mode to a second illumination mode based on a sensed or determined changed condition, such as predetermined temperature and/or change in a scene or brightness signal, or lack of change, from an image sensor that may be associated with the instrument. | 2008-11-20 |
20080287743 | Medical retractor and stabilizing assembly and related methods of use - Embodiments of the invention include endoscopic guide tubes having a retractor and a stabilizing assembly for use with the guide tube and related methods of use. | 2008-11-20 |
20080287744 | Universal vaginal speculum with permanent handle and disposable disconnectable blades that prevent contact of the distal part of the handle with vaginal cavity - A vaginal speculum having a handle portion and a set of blade pairs some of which can be removably attached to the distal end of the handle and others can be slidingly inserted through the proximal end of the handle. Both pairs of the blades have snapping engagement with one and the same locking mechanism of the handle. The handle may constitute a permanent part, and the blades may be disposable. The blades that are connectable to the distal end of the handle are provided with hoods that cover the surfaces on the front ends of the handle parts for protecting these with contact with the patient genitalia. This reduces the chance for transfer of infection from a patient to patient. | 2008-11-20 |
20080287745 | Alarm Device for Preventing Cot Death - The invention relates to a device comprising means for the remote transmission of an active control signal for triggering alarm means ( | 2008-11-20 |
20080287746 | SYSTEM AND METHOD FOR COMMUNICATING HEALTH CARE ALERTS VIA AN INTERACTIVE PERSONAL HEALTH RECORD - An automated system is described for presenting a patient with an interactive personal health record (PHR) capable of delivering individualized alerts based on comparison of evidence-based, best standards of care to information related to the patient's actual medical care. This will assure the patient that the PHR is providing him or her with optimal health care. A health care organization collects and processes a wide spectrum of medical care information, including clinical data relating to a patient and condition-specific medical reference data, in order to generate and deliver customized alerts, including Care Considerations and personalized wellness alerts, directly to the patient via an online interactive personal health record (PHR). In addition to aggregating patient-specific medical record and alert information, the PHR also solicits the patient's input for tracking of alert follow-up actions and allows the health care organization to track alert outcomes. | 2008-11-20 |