46th week of 2015 patent applcation highlights part 26 |
Patent application number | Title | Published |
20150322419 | Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin - Methods and systems for chromatographically purifying a | 2015-11-12 |
20150322420 | RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF - The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. | 2015-11-12 |
20150322421 | TREATMENT FOR AIRWAY CAST OBSTRUCTION - The present invention is directed to methods of treatment of airway obstruction associated with fibrin-containing cast formation by administering a fibrinolytic agent. | 2015-11-12 |
20150322422 | COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS - The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided. | 2015-11-12 |
20150322423 | PROTEIN ALIGNMENT METHOD - A method for aligning proteins is provided. The method for aligning the proteins ( | 2015-11-12 |
20150322424 | BLOOD CELL SORTING METHODS AND SYSTEMS - The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field. The new methods provide for isolation of WBC preparations with high yield, purity, and viability. The methods are designed for compatibility with automation protocols for rapid processing of multiple samples. | 2015-11-12 |
20150322425 | RNA APTAMERS AND METHODS FOR IDENTIFYING THE SAME - RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA aptamers are also disclosed. | 2015-11-12 |
20150322426 | DNA Based Bar Code for Improved Food Traceability - Food distributed to consumers through a distribution chain may be traced by tagging the food with DNA tags that identify the origin of the food, such as the grower, packer and other points of distribution, and their attributes. This makes it much quicker and easier to trace the food in case of food contamination or adulteration. Preferably these attributes indicate the field, location, crew and machine used to grow and process the food, and the dates of the various steps of food harvesting, processing and distribution. Natural or synthetic DNA pieces may be used to tag items, including food items. Multidigit binary or other types of bar codes may be represented by multiple types of DNA. Each digit of the bar code may be represented by one, two or more unique DNA pieces. | 2015-11-12 |
20150322427 | Cancer Treatment and Immune System Regulation Through FAT10 Pathway Inhibition - Described herein are methods of inhibiting mitosis, treating cancer and/or treating immune disorders through the use of agents that inhibit FAT 10 and/or the FAT 10 pathway. | 2015-11-12 |
20150322428 | COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS - The present invention provides method of increasing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides methods for improved cellular uptake. In certain embodiments, the resulting antisense activity is greater at a particular concentration of antisense compound than the antisense activity at the same concentration of the antisense compound in the absence of the ESCRT modulator. | 2015-11-12 |
20150322429 | SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION - Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided. | 2015-11-12 |
20150322430 | TREATMENT OF B-CELL LYMPHOMA WITH MICRORNA - The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL. | 2015-11-12 |
20150322431 | Methods and Compositions of Improved Modified siRNA - Chemically modified small interfering RNAs (siRNAs) that include both phosphorodithioate modifications (PS2-RNA) and 2′-O-methyl modifications (MePS2) provide improved RNA silencing. Specific chemically modified siRNA that show enhanced silencing of RNAs involved in resistance to chemotherapeutic agents are provided. | 2015-11-12 |
20150322432 | COMPOSITIONS AND METHODS FOR FUNCTIONAL NUCLEIC ACID DELIVERY - Provided are derivatized therapeutic, prophylactic, or diagnostic agents, such as nucleic acids, that can be effectively delivered to cells and tissues. Also provided are methods of affecting a biological process by administering a therapeutic, prophylactic, or diagnostic agent, such as functional nucleic acid, to a cell or a subject, where the therapeutic, prophylactic, or diagnostic agent, such as functional nucleic acid, is derivatized therapeutic, prophylactic, or diagnostic agent, such as nucleic acid. | 2015-11-12 |
20150322433 | POST-SYNTHETIC ORTHOGANAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON siRNA - This invention relates to the post-synthetic chemical modifications of RNA at the 2′-position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions. | 2015-11-12 |
20150322434 | INDUCTION OF EXON SKIPPING IN EUKARYOTIC CELLS - The present invention provides a method for at least in part decreasing the production of an aberrant protein in a cell, the cell comprising pre-mRNA comprising exons coding for the protein, by inducing so-call exon skipping in the cell. Exon-skipping results in mature mRNA that does not contain the skipped exon, which leads to an altered product of the exon codes for amino acids. Exon skipping is performed by providing a cell with an agent capable of specifically inhibiting an exon inclusion signal, for instance, an exon recognition sequence, of the exon. The exon inclusion signal can be interfered with by a nucleic acid comprising complementarity to a part of the exon. The nucleic acid, which is also herewith provided, can be used for the preparation of a medicament, for instance, for the treatment of an inherited disease. | 2015-11-12 |
20150322435 | FORMULATIONS FOR TREATING AMYLOIDOSIS - This invention provides pharmaceutical compositions containing a UNA oligomer targeted to TTR and a pharmaceutically acceptable carrier. The compositions can be used in methods for treating or preventing TTR-related amyloidosis in a primate. The compositions, upon administering a single dose to the primate, can reduce TTR protein in the primate for a period of days to weeks. | 2015-11-12 |
20150322436 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR THE USE IN MODULATION OF MICRORNAS - Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activating in a cell. | 2015-11-12 |
20150322437 | Modified Oligonucleotides for Telomerase Inhibition - Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. | 2015-11-12 |
20150322438 | Modified Oligonucleotides for Telomerase Inhibition - Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. | 2015-11-12 |
20150322439 | REPLICATIVE MINICIRCLE VECTORS WITH IMPROVED EXPRESSION - The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of said DNA molecules. | 2015-11-12 |
20150322440 | PROGRAMMABLE SYNTHETIC LYSIS SYSTEM FOR CONTROLLED RELEASE OF MACROMOLECULES - The present invention relates to an expression system or a recombinant cell comprising one or more nucleic acid constructs, wherein the one or more nucleic acid constructs comprise: (i) a first gene encoding for one or more protein(s) that activate a quorum sensing system; and (ii) a second gene encoding for one or more lytic protein(s) capable of forming a lesion in a host cell's membrane; wherein the first gene is under control of a first promoter and the second gene is under control of a second promoter, wherein the first promoter controlling the first gene is a carbon starvation-induced promoter and the second promoter is a quorum sensing system promoter induced by the quorum sensing system activated by one or more protein(s) encoded by the first gene as well as recombinant cells hosting such an expression system. Further encompassed is the use of the expression systems and cells of the invention for the expression of gene products of interest and the respective methods of use. | 2015-11-12 |
20150322441 | BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS - Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid. | 2015-11-12 |
20150322442 | Novel Shuttle Vector Capable of Transforming Multiple Genera of Cyanobacteria - A plasmid vector for the production of compounds in cyanobacteria is described which is capable of being efficiently transformed to and replicating in a broad range of cyanobacterial species. | 2015-11-12 |
20150322443 | SYSTEM FOR CUTTING AND PREPARING SEEDS AND METHOD OF USE - A system and method for the automated or semi-automated cutting of seeds to prepare the seeds for transformation and transgenic engineering. | 2015-11-12 |
20150322444 | ENHANCED ACCUMULATION OF CAROTENOIDS IN PLANTS - The present invention relates to polynucleotides and their use in methods of increasing the carotenoid content of seeds. In particular the invention provides a polynucleotide comprising: (a) a region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence derived from a bacterium which sequence encodes a carotene desaturase; and (iii) a transcription termination region; and (b) a further region which comprises as operably linked components (i) a promoter which provides for seed preferred expression; and (ii) a nucleotide sequence encoding a phytoene synthase which sequence is derived from maize ( | 2015-11-12 |
20150322445 | SELF-INCOMPATIBILITY SYSTEM FOR MAKING BRASSICACEAE HYBRID - The present disclosure provides a genetic system based on the co-expression of the Lal2 polypeptide and the SCRL polypeptide for conferring self-incompatibility to otherwise self-compatible Brassicaceae plants. The genetic system is especially useful for generating Brassicaceae hybrids. | 2015-11-12 |
20150322446 | METHOD FOR REGULATING EXPRESSION OF SPECIFIC PROTEIN USING PHOTORESPONSIVE TRANSCRIPTIONAL FACTOR, ISOPRENOID-PRODUCING PLANT HAVING GENE ENCODING PHOTORESPONSIVE TRANSCRIPTIONAL FACTOR INTRODUCED THEREINTO, AND METHOD FOR PRODUCING POLYISOPRENOID USING SAID ISOPRENOID-PRODUCING PLANT - The present invention provides a method for enhancing the overall pathway of polyisoprenoid biosynthesis. The present invention further provides an isoprenoid-producing plant having an overall enhanced pathway of polyisoprenoid biosynthesis, and a method for producing polyisoprenoids using such an isoprenoid-producing plant. The present invention relates to a method for regulating by a light-responsive transcription factor the expression of at least one protein selected from the group consisting of hydroxymethylglutaryl-CoA reductase, isopentenyl diphosphate isomerase, cis-prenyltransferase, and small rubber particle protein. | 2015-11-12 |
20150322447 | SOYBEAN ROD1 GENE SEQUENCES AND USES THEREOF - The present invention relates to soybean ROD1 nucleic acid sequences and proteins and the use thereof to create plants with increased levels of C18:1 and reduced levels of saturated fatty acids in the seeds. | 2015-11-12 |
20150322448 | METHODS AND COMPOSITIONS FOR ALTERING LIGNIN COMPOSITION IN PLANTS - The invention provides methods for decreasing lignin content in plants by reducing expression of a folylpolyglutamate synthetase 1 (FPGS1) coding sequence in the plant. Also provided are methods for reducing lignin content in a plant by down-regulation of FPGS1 expression in the plant. Nucleic acid molecules for modulation of FPGS1 expression and transgenic plants the same are also provided. Plants described herein may be used, for example, as improved biofuel feedstock and as highly digestible forage crops. Methods for processing plant tissue and for producing biofuels by utilizing such plants are also provided. | 2015-11-12 |
20150322449 | Plants Having Enhanced Yield-Related Traits And Methods For Making The Same - Provided are methods for enhancing yield-related traits in plants by modulating expression of a nucleic acid encoding an ELM2-related polypeptide, or a WRKY-related polypeptide, or an EMG1-like polypeptide, or a GPx-related polypeptide in a plant. Also provided are plants having modulated expression of a nucleic acid encoding an ELM2-related polypeptide, or a WRKY-related polypeptide, or an EMG1-like polypeptide, or a GPx-related polypeptide, which plants have enhanced yield-related traits relative to control plants. Further provided are constructs comprising a nucleic acid encoding an ELM2-related polypeptide, or a WRKY-related polypeptide, or an EMG1-like polypeptide, or a GPx-related polypeptide, useful in carrying out the methods of the invention. | 2015-11-12 |
20150322450 | USE OF FRUCTOKINASES AND SUCROSE SYNTHASES FOR INCREASING CELL WALL POLYMERS - The invention relates to transgenic plants exhibiting increased cell wall content. In one embodiment, transgenic plants engineered to over-express fructokinase (FRK) or both FRK and sucrose synthase (SuSy) are provided. The FRK+SuSy double-transgenic plants of the invention consistently exhibit enhanced cell wall polymer deposition. | 2015-11-12 |
20150322451 | TOBACCO HAVING ALTERED LEAF PROPERTIES AND METHODS OF MAKING AND USING - This disclosure provides tobacco plants containing a PMT RNAi and tobacco plants having a mutation in PMT, and methods of making and using such plants. | 2015-11-12 |
20150322452 | COMPOSITIONS AND METHODS FOR INCREASING PLANT GROWTH AND YIELD - Compositions and methods for increasing plant yield are disclosed. Compositions comprise transcription factors that find use in modulating the expression of a gene or nucleotide sequence of interest in a plant. Additionally, promoters and cis-regulatory elements are disclosed that may be used to drive the expression of a nucleotide sequence of interest in a plant. Methods for the use of such compositions as well as transformed plants are disclosed. | 2015-11-12 |
20150322453 | HERBICIDE-METABOLIZING CYTOCHROME P450 MONOOXYGENASES - The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding non-transformed wild type plant, comprising transforming a plant cell or a plant cell nucleus or a plant tissue with a nucleic acid molecule encoding an | 2015-11-12 |
20150322454 | Genes to Enhance Disease Resistance in Crops - The present invention pertains to methods, means and uses of nucleic acids and polypeptides for conferring, modifying or improving plant resistance against fungal infections. Particularly, the invention provides nucleic acids and polypeptides for conferring, modifying or improving plant resistance against fungal infections. The invention also provides vectors, cells and plants. Also, the invention provides methods for creating corresponding plant cells and plants, and for identification of agents for conferring, modifying or improving plant resistance against fungal infections. | 2015-11-12 |
20150322455 | SEC23 NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN AND HEMIPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran and/or hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran and/or hemipteran pests, and the plant cells and plants obtained thereby. | 2015-11-12 |
20150322456 | DRE4 NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 2015-11-12 |
20150322457 | COMPOSITION FOR CLEAVING A TARGET DNA COMPRISING A GUIDE RNA SPECIFIC FOR THE TARGET DNA AND CAS PROTEIN-ENCODING NUCLEIC ACID OR CAS PROTEIN, AND USE THEREOF - The present invention relates to targeted genome editing in eukaryotic cells or organisms. More particularly, the present invention relates to a composition for cleaving a target DNA in eukaryotic cells or organisms comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof. | 2015-11-12 |
20150322458 | SYNTHETIC GENES AND GENETIC CONSTRUCTS - The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto. | 2015-11-12 |
20150322459 | GENOMIC RNA PACKAGING ENHANCER ELEMENT - A synthetic lentiviral vector construct comprises a genomic RNA packaging enhancer (GRPE) element and lentiviral nucleic acid sequences sufficient for reverse transcription and packaging in a host cell. | 2015-11-12 |
20150322460 | COMPOSITIONS AND METHODS FOR REGULATING THERMOGENESIS AND MUSCLE INFLAMMATION USING METRNL AND METRN - The invention provides compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and/or expression. Also provided are methods for preventing or treating metabolic disorders and muscle inflammation disorders in a subject through modulation of Metrnl and/or Metrn activity and/or expression. Further provided are methods for identifying compounds that are capable of treating metabolic disorders and muscle inflammation disorders by modulating Metrnl and/or Metrn activity and/or expression. | 2015-11-12 |
20150322461 | IMPROVEMENT OF ETHANOL YIELD WITH REDUCTION OF BIOMASS ACCUMULATION IN THE RECOMBINANT STRAIN OF SACCHAROMYCES CEREVISIAE OVEREXPRESSING ALKALINE PHOSPHATE - Described herein is a method to increase ethanol yield during alcoholic fermentation by expression a truncated versions of the | 2015-11-12 |
20150322462 | SORBENT AND PROCESS FOR REMOVING FERMENTATION INHIBITORS - The invention pertains to, for example, an improved sorbent and process for removing fermentation inhibitors such as furfural and/or HMF in microbial processes utilizing fermentable sugars obtained from biomass including, for example, in the production of bioalcohols. The sorbent is capable of separating one or more inhibitors from monosaccharides and is characterized by: (1) a K | 2015-11-12 |
20150322463 | METHOD FOR OBTAINING BIOFUEL FROM LIGNOCELLULOSIC AND/OR AMYLACEOUS BIOMASS - A method for obtaining biofuel from lignocellulosic and/or amylaceous biomass through fermentation in at least one step by using a consortium of microorganisms in order to obtain sugars that later will be converted into alcohols by using environmentally friendly and economically viable methods, as opposed to conventional acid and enzymatic hydrolysis. | 2015-11-12 |
20150322464 | ESCHERICHIA COLI ENGINEERED FOR ISOBUTYRALDEHYDE PRODUCTION - The present disclosure provides recombinant | 2015-11-12 |
20150322465 | RECOMBINANT HOST CELL FOR BIOSYNTHETIC PRODUCTION - A cell may include heterologous polynucleotides encoding a multienzyme complex involved in the metabolic pathway of phenylpropanoids and biosynthesis of a vanilloid or a hydroxybenzaldehyde precursor thereof, which multienzyme complex comprises enzymes for the biosynthesis of coumaric acid and a crotonase. | 2015-11-12 |
20150322466 | MATERIALS AND METHODS FOR USING AN ACYL-ACYL CARRIER PROTEIN THIOESTERASE AND MUTANTS AND CHIMERAS THEREOF IN FATTY ACID SYNTHESIS - A method of increasing production of fatty acids comprising introducing into a host cell or organism and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE) from | 2015-11-12 |
20150322467 | METHOD FOR OPTIMIZING PRODUCTION OF EICOSAPENTAENOIC ACID (EPA) IN A RECOMBINANT HOST - The present invention relates to a method for optimizing production of eicosapentaenoic acid (EPA) production by cloning genes into a bacterial host, most preferably a modified | 2015-11-12 |
20150322468 | METHOD OF PRODUCING BIOFUEL USING MICROALGAE CULTURES - The present invention relates to methods of improving TAG production of microalgae, for example, the microalgae in microalgal mass culture systems, and compositions of the improved microalgae. The method of improving TAG production may be increasing the yield of TAG produced by each microalgae or increasing the total yield of a mass culture system by increasing the number of microalgae in the mass culture system. | 2015-11-12 |
20150322469 | Process For The Fermentative Preparation Of Sulphur-Containing Amino Acids - The invention relates to a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps:
| 2015-11-12 |
20150322470 | MALTITOL POWDER - The present invention relates to a process for preparing solidified or crystalline maltitol. The process is comprising the successive steps of liquefaction of a starch milk and saccharification of the liquefied starch milk in the presence of alpha-amylase, beta-amylase and a debranching enzyme selected from the group of pullulanase, iso-amylase and mixtures thereof, preferably pullulanase and further adding maltogenic alpha-amylase and/or iso-amylase, for obtaining a maltose containing syrup comprising at least 85% maltose based on dry matter and less than 1.5% glucose based on dry matter, preferably less than 1% glucose based on dry matter, followed by molecular sieving of the maltose containing syrup to obtain a fraction (A) comprising at least 95% maltose based on dry substance of fraction (A), and further hydrogenating catalytically fraction (A) for obtaining a liquid maltitol enriched product (B). Finally the liquid enriched product is solidified or crystallised for preparing a solidified or crystalline maltitol. | 2015-11-12 |
20150322471 | PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL - The invention relates to a process for the hydrolysis of cellulose containing biomass which comprises
| 2015-11-12 |
20150322472 | Reducing Template Independent Primer Extension and Threshold Time for Loop Mediated Isothermal Amplification - Compositions and methods are provided for loop mediated isothermal amplification in which single stranded binding proteins are shown to protect primers from non-specific extension and to stimulate the rate of threshold amplification. | 2015-11-12 |
20150322473 | Methods and materials for Biosynthesis of Mogroside Compounds - The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention. | 2015-11-12 |
20150322474 | IN VITRO PRODUCTION OF CYCLIC PEPTIDES - This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from | 2015-11-12 |
20150322475 | ELECTRODE FOR URIC ACID AND METHOD OF PRODUCING THE SAME - Embodiments of this invention disclose new second generation uric acid-sensing electrodes at least characterized by chemically bonding both uricase and the redox mediator to an electrode. The produced electrodes can be long-term stably used without losing activity. The developed electrode has been successfully applied for the analysis of uric acid (UA) in healthy human urine specimens which exhibits very good analysis accuracy and precision without too much interference. Therefore, the developed electrodes have the potential for clinical applications. | 2015-11-12 |
20150322476 | METHODS, DEVICES, AND SYSTEMS OF DETECTING MICROORGANISMS - A rapid, sensitive method of separating and detecting microorganisms from a sample potentially containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample potentially containing microorganisms. The sample may be a chemical (e.g., household cleaners), cosmetic, personal care, pharmaceutical, or consumable (e.g., food or beverage) good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer. | 2015-11-12 |
20150322477 | INFECTION MEDIATED FOAM DISSOLUTION RATE MEASUREMENT - The subject invention concerns methods and materials for determining the presence or absence of bacterial or fungal infection in a blood sample. In one embodiment, a method of the invention comprises exposing an anticoagulant treated blood sample to freezing the sample to a solid, followed by thawing of the sample and then agitation of the sample to develop foam and then observing the rate that foam dissolves. | 2015-11-12 |
20150322478 | DETECTION OF BACTERIA AND FUNGI - A method of detecting a ligase expressing micro-organism in a sample comprises steps of treating the sample under conditions that inhibit the activity of ATP-dependent ligase from mammalian cells but which do not inhibit the activity of the microbial ligases, contacting the sample or a portion of the sample with a nucleic acid molecule which acts as a substrate for ligase activity in the sample, incubating the thus contacted sample under conditions suitable for ligase activity; and specifically determining the presence and/or the amount of a ligated nucleic acid molecule resulting from the action of the ligase on the substrate nucleic acid molecule to indicate the presence of the ligase expressing micro-organism. The micro-organism may be a fungus or a bacterium or both. High pH conditions may be employed to inactivate mammalian ligases. Related kits are described. | 2015-11-12 |
20150322479 | APPARATUS AND METHOD FOR QUANTIFICATION OF REPLICATIVE LIFESPAN AND OBSERVATION OF SENESCENE - The present invention teaches an apparatus and method for the automated study of senescence of cells. The apparatus includes a plurality of plates, customized with a flow-through hole, arranged on a platform. A microscope with integrated camera is positioned above the platform and both microscope and platform are coupled to a rotation mechanism to allow relative rotation between the platform and the microscope. Cells are anchored magnetically, chemically, or electrostatically to the plates and are treated to a controlled environment. Daughter cells born from the mother cell are observed by the microscope and then washed, using a wash fluid, through the flow-through hole in the plate. A processor automates the process and allows for a user to input customizable test parameters and value thresholds to indicate a test is completed. The processor also organises test data in the form of a spreadsheet for simple modelling and data manipulation. | 2015-11-12 |
20150322480 | METHOD FOR MEASURING THROMBIN GENERATION - It is an object of the present invention to provide a measurement method capable of easily evaluating combined effects in a single assay system, when antithrombotic agents having different mechanisms of action are used in combination. A method for measuring thrombin generation comprising: (1) a step of adding an anticoagulant, a P2Y | 2015-11-12 |
20150322481 | APPARATUS FOR DETECTING ATP IN A LIQUID SAMPLE - An apparatus ( | 2015-11-12 |
20150322482 | COMPOSITIONS AND METHODS FOR MONITORING TRANSMEMBRANE TRAFFICKING - Provided herein are compositions and methods for monitoring the movement of analytes and/or cellular components across biological membranes (e.g., cell surface internalization). In particular, reporter constructs are provided, the transmembrane movement of which (e.g., by endocytosis) is monitored by methods described herein. | 2015-11-12 |
20150322483 | METHOD FOR DETECTING NUCLEIC ACID AND NUCLEIC ACID DETECTION KIT - Disclosed is a method for detecting a nucleic acid using a substance that suppresses, in the labeling step of the post-staining method, detachment of a target nucleic acid that has once hybridized with a capture probe immobilized on a support, which method enables detection of the target nucleic acid with a sensitivity equivalent to or higher than that achieved by a method using sodium ion even in cases where the substance is used at a lower concentration. The method for detecting a nucleic acid comprises the steps of: (1) hybridizing a capture probe with a target nucleic acid to form a double-stranded nucleic acid; bringing the formed double-stranded nucleic acid into contact with a solution containing a labeling substance and a divalent metal cation at a concentration of not less than 10 mM to introduce the labeling substance into the double-stranded nucleic acid; and detecting the labeling substance introduced into the double-stranded nucleic acid. | 2015-11-12 |
20150322484 | NUCLEIC ACID DENATURATION APPARATUS, METHOD FOR DENATURING NUCLEIC ACID AND METHOD FOR AMPLIFYING NUCLEIC ACID - [Problem] To provide an apparatus for denaturing double strand nucleic acids to single strand nucleic acids, and a method for denaturing double strand nucleic acids to single strand nucleic acids, which may become an alternative means to the thermal denaturation. | 2015-11-12 |
20150322485 | METHOD OF ISOLATING BIOCHEMICAL MOLECULES ON MICROARRAY SUBSTRATE - Provided is a method of isolating biochemical molecules on a microarray substrate, the method including providing a microarray substrate to which clusters of different kinds of biochemical molecules being classified by individual spot units are attached, the individual spots being regularly arranged thereon; obtaining location information of the individual spot in which a desired cluster among clusters of the biochemical molecules locates; locating an extraction tool for applying energy to isolate the desired cluster according to the location information; and isolating the desired cluster from the microarray substrate by applying energy in a contact or non-contact manner using the extraction tool. | 2015-11-12 |
20150322486 | LABEL-FREE METHODS FOR ISOLATION AND ANALYSIS OF NUCLEIC ACIDS ON SOLID PHASE DEVICE - Methods and system for the isolation and/or analysis of nucleic acids on a solid phase device comprising (i) incubating a nucleic acid sample with Dimethyl adipimidate (DMA) on said solid phase under conditions that allow formation of a complex of the nucleic acid with the DMA; contacting the complex of (i) with said surface; and isolating and/or analyzing the nucleic acid of the complex. | 2015-11-12 |
20150322487 | REAL-TIME, LABEL-FREE DETECTION OF MACROMOLECULES IN DROPLETS BASED ON ELECTRICAL MEASUREMENTS - A method for detecting presence of a macromolecule of interest in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical characteristics (e.g., impedance) of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing the macromolecule of interest or free of the macromolecule at the first frequency. The presence of the macromolecule in the test droplet is thus determined based on the comparison. | 2015-11-12 |
20150322488 | Instrument for Monitoring Polymerase Chain Reaction of DNA - An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes. | 2015-11-12 |
20150322489 | SILICA-BASED BIOLOGICAL MATERIAL ISOLATION - An apparatus for isolating nucleic acids includes an elongated body. The elongated body includes a silica surface positioned and configured to bind the nucleic acids when the elongated body is dipped into a biological material sample. | 2015-11-12 |
20150322490 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 2015-11-12 |
20150322491 | High density self-contained biological analysis - Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and detection and immune-PCR. | 2015-11-12 |
20150322492 | METHODS AND KITS FOR IDENTIFYING MICROORGANISMS IN A SAMPLE - Disclosed herein are compositions with uniquely designed oligonucleotide primers for identifying a plurality of microorganisms in a sample, and improved methods for detection of microbial populations from diverse biological and environmental samples. | 2015-11-12 |
20150322493 | METHOD AND ITS COMPOSITIONS FOR DETECTION OF NUCLEIC ACID TARGET FROM BIOLOGICAL SAMPLES AND BODY FLUIDS - Current invention is directed for rapid sample pretreatment method that allows highly sensitive and specific detection of target nucleic acid (eg human genomic DNA, human pathogen genomic DNA, human non-pathogen genomic DNA) by amplification directly from crude unpurified biological samples lysates (eg human urine, saliva, blood, urethra and cervical swabs and other samples containing biological material). Invention is focused on the description of the biological sample pretreatment method that enables fast release of the genomic material from human and pathogen cells, components of what are compatible with the following nucleic acid amplification method. As an example of the application, invention also discloses protocols and primer sequences for isothermal nucleic acid amplification (recombinase polymerase amplification—RPA, loop-mediated isothermal amplification—LAMP), that enable highly specific and sensitive diagnostics of the genomic material from | 2015-11-12 |
20150322494 | HIGH-THROUGHPUT SCREENING METHOD FOR THE IDENTIFICATION OF BIOMARKERS, THERAPEUTIC TARGETS OR THERAPEUTIC AGENTS - The present invention relates to a method for screening a molecule of interest by means of nanoparticles comprising a candidate molecule, a tracer, and a single DNA tag specific to said molecule. The present invention also relates to a method for screening biomarkers of a disease and/or of a phenotype feature, more particularly of a cancer or an infection, by means of said nanoparticles. The invention finally relates to the nanoparticles as such as well as to a library of said nanoparticles. | 2015-11-12 |
20150322495 | COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGEN NUCLEIC ACID - Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and combinations thereof, for detection of one or more gastrointestinal pathogens selected from | 2015-11-12 |
20150322496 | METHOD FOR SCREENING LACTIC ACID BACTERIA HAVING IMMUNOREGULATORY FUNCTION - This invention provides a means for screening for lactic acid bacteria having immunoregulatory functions in a simple and rapid manner. This invention provides a method for screening for or producing lactic acid bacteria having immunoregulatory functions comprising determining the number of the test lactic acid bacteria bound to the uromodulin (Umod) protein, lactic acid bacteria obtained by such method, and an immunoregulatory composition comprising such lactic acid bacteria. | 2015-11-12 |
20150322497 | RAPID SALMONELLA SEROTYPING ASSAY - Processes for the serotype specific detection and identification of one or more | 2015-11-12 |
20150322498 | METHOD FOR LABELLING OF CLEAVAGE OF NUCLEIC ACID SEQUENCE - Method for properly identifying and determining a target nucleic acid when the target nucleic acid is cleaved. The method includes a step of bringing a hybridization solution into contact with a target nucleic acid, wherein the hybridization solution contains a probe set that is composed of at least two labelled probes respectively labelled with different identifying factors and may hybridize with almost the full length of the sequence for the target nucleic acid. The method further includes a step of causing the identifying factors to develop the functions thereof to produce signals. | 2015-11-12 |
20150322499 | METHOD FOR ANALYZING MOLECULE USING THERMOPHORESIS - A method for analyzing a target molecule using thermophoresis is provided. The method of the invention comprises (1) providing a solution containing samples, labeled molecules, and probe particles; (2) providing a temperature control system to create a temperature gradient within the solution; (3) detecting the expression level of the labeled molecule in a predetermined area and a contrast area; and (4) analyzing the difference in the expression level of the labeled molecules between the predetermined area and the contrast area to determine the result. In another embodiment of the invention, the solution contains samples and “labeled molecule-reactant-probe particle” complexes. In the present invention, the probe particles are used to increase the difference in thermophoresis between the molecular complexes and the free labeled molecules, which can improve the accuracy of the quantification of the target molecules using thermophoresis. | 2015-11-12 |
20150322500 | Multiplexed diagnostic platform for point-of care pathogen detection - The invention provides a system for high-throughput multiplex analysis of target samples. A sample and reagent delivery unit is operatively connected to a thermal cycler for amplification of target nucleic acids. Microspheres are hybridized to the resulting amplicons in the thermal cycler. A flow cytometer is operatively connected to the thermal cycler or optionally a bead trap for washing the microspheres. | 2015-11-12 |
20150322501 | MEASUREMENT METHOD OF TELOMERASE ACTIVITY - The present disclosure provides a measurement method of telomerase activity with no occurrence of false-negative and high quantitative capability. In the measurement method of telomerase activity of the present disclosure, a solution containing telomerase as a sample solution is mixed with a solution containing primer DNA as a substrate for telomerase even as or after a solution containing non-primer DNA not as a substrate for telomerase is mixed therewith. Non-primer DNA can remove an effect of DNase in the sample solution and prevent occurrence of false-negative. Subsequently, the primer DNA is extended with the telomerase and the extended primer DNA is detected, through which telomerase activity is measured. | 2015-11-12 |
20150322502 | METHODS AND REAGENTS FOR REDUCING NON-SPECIFIC AMPLIFICATION - The present invention provides reagents for use in the amplification of nucleic acids. Amplification carried out using oligonucleotides containing modified nucleotides can result in less non-specific amplification compared to amplification carried out using unmodified oligonucleotides. | 2015-11-12 |
20150322503 | Reagents and Methods of PCR - Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least 32° C., and that include 2-4 modifying groups, each covalently attached to a different terminal region, preferably to a terminal nucleotide, said modifying groups being polycyclic substituents that do not have bulky portions that are non-planar, said modified oligonucleotide being capable of binding to the 5′ exonuclease domains of DNA polymerases and, when included in a PCR or other primer-dependent DNA amplification reaction at a concentration, generally not more than 2000 nM, that is effective for at least one of the functions of suppressing mispriming, increasing polymerase selectivity against 3′ terminal mismatches. increasing polymerase selectivity against AT-rich 3′ ends, reducing scatter among replicates, suppressing polymerase 5′ exonuclease activity, and inhibiting polymerase activity; as well as amplification reaction mixtures containing such modified double-stranded oligonucleotides, and amplification reactions, amplification assays and kits that include such modified double-stranded oligonucleotides. | 2015-11-12 |
20150322504 | SEQUENCE AMPLIFICATION WITH LOOPABLE PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing the amplification of the target nucleic acid sequences. | 2015-11-12 |
20150322505 | BARRIER COATED NANO STRUCTURES - The present invention relates to a device comprising a nano-structure and a corresponding method of manufacturing, wherein said nano-structure is made of electrically conductive material and wherein said nano-structure is covered by a barrier coating comprising Ti, Zr, Hf, Nb, Ta, Mo, Sc, Y, Ge, La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm, Yb, Lu, Sr, Al, B, Ba, Bi, and/or Mg oxide in a thickness of at least about 1 nm, wherein said barrier coating is deposited by atomic layer deposition (ALD). The present invention also relates to a method of detecting a target compound in such a device, the use of such a device for surface specifically creating an evanescent field, measuring the dielectric properties of a medium, detecting the presence or the concentration of a target compound, determining the primary structure of a target compound, determining a deviation of the target compound from a control value, amplifying a target compound, or monitoring the amplification of a target compound. | 2015-11-12 |
20150322506 | Methods and Compositions for Discrimination Between Cytosine and Modifications Thereof, and for Methylome Analysis - Compositions and methods are provided for discrimination between cytosine and modifications thereof using cytidine deaminases and/or oxygenases. Variants of wild type cytidine deaminases are described which show reduced bias with respect to adjacent nucleotides upstream of the cytosine. The methods provide a rapid and convenient use of enzymes to obtain methylomes. | 2015-11-12 |
20150322507 | METHODS FOR SIMULTANEOUS AMPLIFICATION OF TARGET LOCI - The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons. | 2015-11-12 |
20150322508 | METHOD FOR COMPLETE TRACKING OF A SET OF BIOLOGICAL SAMPLES CONTAINING DNA OR RNA THROUGH MOLECULAR BARCODE IDENTIFICATION DURING LABORATORIAL WORKFLOW AND KIT FOR COLLECTING BIOLOGICAL SAMPLES CONTAINING DNA OR RNA - The present invention discloses a method for complete tracking of a set of biological samples containing DNA or RNA through the use of molecular barcode identification during the course of laboratorial workflow, wherein the sample is contacted with primers comprising a molecular barcode and a universal primer sequence immediately after its collection and the amplification of the target regions occurs concomitantly to the barcode insertion, in one or both ends of said target region, in the same annealing temperature through a one step PCR. Finally, the invention also discloses kits for collecting biological samples containing DNA or RNA. | 2015-11-12 |
20150322509 | GENOTYPING METHOD - The present invention relates to a genotyping method, and more particularly to an ID sequence, which is assigned to each genotype, and a multiplex genotyping method which uses the ID sequence. When pyrosequencing is performed using the ID sequence, a unique and simple pyrogram can be obtained for each genotype. Thus, the use of the ID sequence makes it possible to genotype viral genes, disease genes, bacterial genes and identification genes in a simple and efficient manner. In addition, a genotyping primer of the invention can be used in various genotyping methods which are performed using dispensation orders and sequencing methods. | 2015-11-12 |
20150322510 | TWO-PRIMER PCR FOR MICRORNA MULTIPLEX ASSAY - The present invention provides method for amplifying a specific RNA molecule in a sample, the method comprising: (a) adding a poly(ribonucleotide) sequence to RNA molecules in the sample; (b) reverse transcribing the poly-adenylated RNA molecules using a reverse primer comprising a sequence that anneals to said poly(ribonucleotide) sequence; and (c) amplifying and detecting the cDNA molecule(s) using the same reverse primer and using a forward primer specific for the RNA molecule to be detected; wherein at least one of the forward and reverse primers comprises a hairpin primer. The invention also provides kits useful for practicing this method. | 2015-11-12 |
20150322511 | DETECTION OF DNA THAT ORIGINATES FROM A SPECIFIC CELL-TYPE - The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting an increased risk of an individual suffering from or developing a medical condition such as preeclampsia or cancer, and/or to aid subsequent diagnostic, prognostic and/or predictive methods such as the detection of chromosomal trisomy in a foetus, including for twin-pregnancies. The present invention also relates to compositions, kits, computer program products and other aspects that are used in, useful for or related to the practice of such methods. | 2015-11-12 |
20150322512 | MULTIPLEX DETECTION OF DNA THAT ORIGINATES FROM A SPECIFIC CELL-TYPE - The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on different methylation, at certain regions of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting an increased risk of an individual suffering from or developing a medical condition such as preeclampsia or cancer, and/or to aid subsequent diagnostic, prognostic and/or predictive methods such as the detection of chromosomal trisomy in a foetus, including for twin-pregnancies. The present invention also relates to compositions, kits, computer program products and other aspects that are used in, useful for or related to the practice of such methods. | 2015-11-12 |
20150322513 | MULTIPLEX DETECTION OF DNA THAT ORIGINATES FROM A SPECIFIC CELL-TYPE - The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA thst originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting an increased risk of an individual suffering from or developing a medical condition such as preeclampsia or cancer, and/or to aid subsequent diagnostic, prognostic and/or predictive methods such as the detection of chromosomal trisomy in a foetus, including for twin-pregnancies. The present invention also relates to compositions, kits, computer program products and other aspects that are used in, useful for or related to the practice of such methods. | 2015-11-12 |
20150322514 | DIAGNOSTIC MARKERS FOR PLATELET FUNCTION AND METHODS OF USE - Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient. | 2015-11-12 |
20150322515 | METHODS AND COMPOSITIONS FOR DETECTING TARGET SNP - The present invention provides methods and compositions, and uses thereof, for simultaneously detecting one target SNP locus or multiple target SNP loci in a sample. In exemplary embodiments, the present invention also provides a multiplex SNP assay technique, which can simultaneously detect up to 20 SNP loci (40 alleles) with high level of specificity (e.g., >99.9%), sensitivity (e.g. 100%) and accuracy, high throughput, cost-effective and time-saving, reduced or no false-negative results. The present invention further provides certain isolated polynucleotides that can be used as primers or primer pairs in the present methods and composition for simultaneously detecting one target SNP locus or multiple target SNP loci in a sample. | 2015-11-12 |
20150322516 | UV Associated mtDNA Fusion Transcripts and Methods and Uses Thereof - The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products. | 2015-11-12 |
20150322517 | AGENTS AND METHODS FOR DIAGNOSING STRESS - The present invention discloses molecules and assays for qualitatively or quantitatively determining the effect of stress on the immune system, the susceptibility to developing disease or illness through immune system dysfunction as a result of stress, and for monitoring the ability of an animal to cope with stress. The invention is useful inter alia in measuring response to immunomodulatory therapies, and monitoring the immune response to natural disease under stressful conditions. | 2015-11-12 |
20150322518 | BIOMARKERS FOR AUTISM SPECTRUM DISORDERS - Methods of determining the risk of ASD in an individual are provided which comprise identifying the presence of one or more genomic mutations in one or more of the genes, PTCHD1, SHANK3, NFIA, DPP6, DPP10, DYPD, GPR98, PQBP1, ZNF41 and FTSJ1. | 2015-11-12 |