43rd week of 2009 patent applcation highlights part 37 |
Patent application number | Title | Published |
20090263722 | NEGATIVE ELECTRODE FOR LITHIUM PRIMARY BATTERY AND LITHIUM PRIMARY BATTERY - A lithium primary battery includes a positive electrode, a negative electrode, a separator, a positive electrode case, a negative electrode case, a gasket, and a non-aqueous electrolyte. The negative electrode includes: lithium or a lithium alloy; a lithium carboxylate layer formed on a surface of the lithium or lithium alloy; and a carbon layer formed on a surface of the lithium carboxylate layer. This configuration allows the lithium primary battery to have suppressed negative electrode polarization during discharge and improved large-current discharge characteristics in a low temperature environment and after high temperature storage. | 2009-10-22 |
20090263723 | APROTIC POLYMER/MOLTEN SALT TERNARY MIXTURE SOLVENT, METHOD FOR THE PRODUCTION AND USE THEREOF IN ELECTROCHEMICAL SYSTEMS - The invention relates to an aprotic polymer/molten salt ternary mixture solvent and to a corresponding quaternary mixture additionally comprising an ionic conducting salt, which are prepared by mixing the constituents of the mixture. These mixtures are advantageously used in the preparation of electrochemical membranes, electrochemical systems and of electrochromic systems. The invention also relates to electrochemical and electrochromic systems obtained hereby that exhibit, in particular, excellent electrochemical properties at low temperatures. | 2009-10-22 |
20090263724 | Nanostructure material, method for the preparation thereof - The invention relates to a nanostructured material. | 2009-10-22 |
20090263725 | High Elastic Modulus Polymer Electrolytes - A polymer that combines high ionic conductivity with the structural properties required for Li electrode stability is useful as a solid phase electrolyte for high energy density, high cycle life batteries that do not suffer from failures due to side reactions and dendrite growth on the Li electrodes, and other potential applications. The polymer electrolyte includes a linear block copolymer having a conductive linear polymer block with a molecular weight of at least 5000 Daltons, a structural linear polymer block with an elastic modulus in excess of 1×10 | 2009-10-22 |
20090263726 | ANODE AND METHOD OF MANUFACTURING SAME, SECONDARY BATTERY AND METHOD OF MANUFACTURING SAME, AND SULFONE COMPOUND - A secondary battery capable of improving the cycle characteristics is provided. The secondary battery includes a cathode and an anode oppositely arranged with a separator in between, and an electrolytic solution. At least one of the cathode, the anode, the separator, and the electrolytic solution contains a sulfone compound having a carbonate group and a sulfonyl group. | 2009-10-22 |
20090263727 | Lithium cell with cathode including iron disulfide and iron sulfide - A primary cell having an anode comprising lithium or lithium alloy and a cathode comprising iron disulfide (FeS | 2009-10-22 |
20090263728 | Centrifugal atomization for producing zinc powder - A centrifugal impact atomization process for producing zinc or zinc alloy powder from molten zinc. A stream of molten zinc is injected onto the surface of a spinning disk contained within an atomization chamber. The disk has a cup shaped cavity having an open end, opposing closed end and integral side walls. The disk may have baffles protruding into the open cavity core within the disk. The baffles may have straight or curved side surfaces. The disk is rotated at high speeds between about 10,000 and 15,000 rpm (revolutions per minute). The oxygen content in the chamber is preferably between about 1 and 6 vol %. Zinc powder is produced having more smaller size particles. Zinc alkaline cells utilizing such zinc product as anode active material show improved performance, especially as power source in high discharge services such as digital cameras. | 2009-10-22 |
20090263729 | TEMPLATES FOR IMPRINT LITHOGRAPHY AND METHODS OF FABRICATING AND USING SUCH TEMPLATES - A template for use in imprint lithography is disclosed. The template includes at least two ultraviolet transparent materials bonded together by an ultraviolet transparent epoxy. The ultraviolet transparent epoxy is a polymeric, spin-on epoxy or a two-part, amine-cured epoxy having a viscosity at room temperature of from about 35,000 cps to about 45,000 cps. The template has a substantially uniform index of refraction. Additionally, methods of forming and using the templates are disclosed. | 2009-10-22 |
20090263730 | EXTREME ULTRA VIOLET LITHOGRAPHY MASK AND METHOD FOR FABRICATING THE SAME - A method for fabricating an extreme ultra violet lithography mask includes forming a reflective layer that reflects an extreme ultra violet light on a substrate; forming a capping layer that transmits the extreme ultra violet light on the reflective layer; and forming selectively pores in some region of the capping layer to form a light absorption region that absorbs the extreme ultra violet light. | 2009-10-22 |
20090263731 | Method for Fabricating Fine Pattern in Photomask - A method for fabricating a fine pattern in a photomask includes forming a light shielding layer over a substrate; forming a first resist layer pattern over the light shielding layer to expose the light shielding layer with a first critical dimension; forming a groove by etching the portion of the light shielding layer exposed by the first resist layer pattern to a first depth; exposing an upper surface of the light shielding layer by removing the first resist layer pattern; forming a second resist layer pattern over the exposed upper surface of the light shielding layer so that a bottom of the groove is partially exposed; and forming a light shielding layer pattern by etching the portion of the light shielding layer exposed by the second resist layer pattern to a second depth so that the substrate is exposed with a second critical dimension which is smaller than the first critical dimension. | 2009-10-22 |
20090263732 | MASK PATTERNS INCLUDING GEL LAYERS FOR SEMICONDUCTOR DEVICE FABRICATION - Mask patterns include a resist pattern and a gel layer on a surface of the resist pattern having a junction including hydrogen bonds between a proton donor polymer and a proton acceptor polymer. Methods of forming the mask patterns and methods of fabricating a semiconductor device using the mask patterns as etching masks are also provided. | 2009-10-22 |
20090263733 | PHOTO MASK, FOCUS MEASURING METHOD USING THE MASK, AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - A photo mask includes an asymmetrical diffraction grating pattern in which diffraction efficiencies of plus primary diffracted light and minus primary diffracted light are different, the asymmetrical diffraction grating pattern including a shielding portion which shields light, a first transmitting portion which transmits light, and a second transmitting portion which transmits light, a ratio of widths of the shielding portion, the first transmitting portion, and the second transmitting portion being n11 where n is a positive real number except 2, the asymmetrical diffraction grating pattern approximately satisfying 163°≦360°/(n+2)+θ≦197° where θ (≠90°) indicates an absolute value of a difference between a phase of the light transmitted through the first transmitting portion and that of the light transmitted through the second transmitting portion, and a reference pattern for obtaining an image as a reference for measuring a shift of an image of the asymmetrical diffraction grating pattern. | 2009-10-22 |
20090263734 | Lithographic Apparatus and Device Manufacturing Method - In optical maskless lithography, scanning of a single substrate is typically much slower than in conventional lithography. Solutions are described for the adoption of immersion lithography techniques into optical maskless lithography and in particular provides one or more solutions to reduce the amount of time which the immersion liquid is in contact with any given part of the top surface of the substrate during imaging. | 2009-10-22 |
20090263735 | EXPOSURE APPARATUS - An exposure apparatus includes a plurality of module each of which is configured to expose a pattern of an original onto the substrate using light from a light source, each module including a projection optical system configured to project the pattern of the original onto the substrate and designed to have an identical structure, and a controller configured to control exposures of the plurality of modules using a correction value that is set for each module and configured to correct a scatter of an imaging characteristic of the pattern of the original to be exposure onto the substrate, the controller obtaining the correction value from an inspection result obtained by sequentially mounting an inspection original onto each module. | 2009-10-22 |
20090263736 | EXPOSURE APPARATUS, EXPOSURE METHOD, AND DEVICE MANUFACTURING METHOD - A pattern image generation device generates a pattern image, and at least a part of the pattern image which has been generated or the pattern image which is generated and is formed on an object is photoelectrically detected by a detection system. Then, a correction device corrects design data that should be input to the pattern image generation device based on the detection results. Accordingly, a pattern image is generated on an object by the pattern image generation device corresponding to the input of the design data after the correction, and because the object is exposed using the pattern image, a desired pattern is formed on the object with good precision. | 2009-10-22 |
20090263737 | IMAGING MEMBER AND METHODS OF FORMING THE SAME - The presently disclosed embodiments are directed to an imaging member having an outermost layer formulation that includes wax particles which creates a rough surface morphology for the layer and imparts increased scratch resistance, reduced torque, and improved cleaning performance to the layer. In embodiments, the outermost layer is an overcoat layer used for an improved imaging member having a substrate, a charge transport layer, and an overcoat positioned on the charge transport layer. | 2009-10-22 |
20090263738 | TONER - An object of the present invention is to provide a spherical toner that has a sharp particle size distribution and a small particle diameter. This is a capsule-type toner that exhibits an excellent low-temperature fixability, while at the same time having a high offset resistance and excellent charging properties and having the ability to provide a high-quality image in which the characters, lines, and dots are precisely defined. The object is achieved by a toner comprising a toner particle that comprises at least (a) resin having polyester as the main component, colorant, wax, and (b) urethane resin, wherein the hydroxyl value per specific surface area of the toner particle is fall into the specific range, and wherein a Tg(0.5) and a Tg(4.0)-Tg(0.5) of the toner fall into specific range. | 2009-10-22 |
20090263739 | RESIN-FILLED CARRIER FOR ELECTROPHOTOGRAPHIC DEVELOPER, AND ELECTROPHOTOGRAPHIC DEVELOPER USING THE RESIN-FILLED CARRIER - A resin-filled carrier for an electrophotographic developer obtained by filling resin into voids of a porous ferrite core material, wherein the porous ferrite core material has a pore volume of 0.04 to 0.16 mL/g and a peak pore size of 0.9 to 2.0 μm, and an electrophotographic developer using this resin-filled carrier. | 2009-10-22 |
20090263740 | TONER COMPOSITIONS - The present disclosure provides processes for reducing the particle size of latex resins and toners produced with such resins. In embodiments, a gel latex may be formed as a seed particle and then utilized to form latex resins and toner particles. In accordance with the present disclosure, one may be able to utilize materials for the production of latex resins and toners which may otherwise produce particles that are too large in the absence of the gel latex. | 2009-10-22 |
20090263741 | POSITIVE RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN - A positive resist composition that includes a resin component (A) and an acid generator component (B), wherein the component (A) includes a polymer compound (A1) having a structural unit (a0) represented by a general formula (a0) shown below, and a structural unit (a1), which is derived from an (α-lower alkyl) acrylate ester containing an acid-dissociable, dissolution-inhibiting group and is not classified as the structural unit (a0): | 2009-10-22 |
20090263742 | CHEMICALLY AMPLIFIED POSITIVE RESIST COMPOSITION - The present invention provides a chemically amplified resist composition comprising:
| 2009-10-22 |
20090263743 | RESIST POLYMER AND RESIST COMPOSITION - The resist polymer of the present invention comprises a specific constitutional unit having a cyano group, a constitutional unit having an acid-dissociable group, and a specific constitutional unit having a lactone skeleton. When the above polymer is used as a resist resin in DUV excimer laser lithography or electron beam lithography, it exhibits high sensitivity and high resolution, and provides a good resist pattern shape, having a small degree of occurrence of line edge roughness or generation of microgels. | 2009-10-22 |
20090263744 | ETHYLENICALLY UNSATURATED COMPOUND, LIGHT SENSITIVE COMPOSITION, LIGHT SENSITIVE PLANOGRAPHIC PRINTING PLATE MATERIAL AND PRINTING PROCESS EMPLOYING THE SAME - The present invention provides a novel ethylenically unsaturated compound which is highly sensitive to scanning exposure due to an ultraviolet to near-infrared laser and is cured to give good physical properties; a light sensitive composition providing good developability and high sensitivity and forming a high strength layer; a planographic printing plate material having advantages that good developability, high sensitivity and high strength layer are obtained, particularly a planographic printing plate material requiring no developing machine which are mounted on a printing press without any development, followed by printing and which provides excellent developability on a printing press and printing durability; and a printing process. The ethylenically unsaturated compound has in the molecule a photo-oxidation group and a polymerizable ethylenically unsaturated bond, and has a predetermined solubility in water or an aqueous alkali solution. The planographic printing plate material is characterized in that it comprises a support and provided thereon, a light sensitive layer containing the ethylenically unsaturated compound, a polyhalogen compound as a photopolymerization initiator, a water-soluble polymer binder as a polymer binder and an infrared absorbing agent. | 2009-10-22 |
20090263745 | POLYIMIDE PRECURSOR, RESIN COMPOSITION COMPRISING THE POLYIMIDE PRECURSOR, PATTERN FORMING METHOD USING THE RESIN COMPOSITION, AND ARTICLES PRODUCED BY USING THE RESIN COMPOSITION - It is a main object of the present invention to provide a polyimide precursor and a polyimide precursor resin composition, which precursor being easy to synthesize, available at low cost, excellent in storage and capable of giving polyimide that is low in impurities after imidization, irrespective of the chemical structure of the finally-obtained polyimide. | 2009-10-22 |
20090263746 | METHOD OF MAKING LITHOGRAPHIC PRINTING PLATES WITH SIMPLE PROCESSING - A negative-working lithographic printing plate precursor can be imaged with infrared radiation and processed in a single step using a single processing solution that has a pH of from about 2 to about 11 and contains an anionic surfactant. This single processing solution both develops the imaged precursor and provides a protective coating that need not be rinsed off before lithographic printing. The lithographic printing plate precursor contains a particulate polymeric binder. | 2009-10-22 |
20090263747 | THREE AXIS LINEAR ACTUATOR | 2009-10-22 |
20090263748 | Method of manufacturing wiring circuit board - A method of manufacturing a wiring circuit board includes: preparing an insulating layer; forming conductive thin films on the upper surface and the side end surface of the insulating layer; covering the conductive thin films formed on the upper surface and the side end surface of the insulating layer with photoresists; arranging a photomask so that an end portion and a portion to be provided with a conductive layer in the conductive thin film formed on the upper surface of the insulating layer are shaded and exposing the photoresist covering the conductive thin film formed on the upper surface of the insulating layer from above through the photomask; exposing the photoresist covering the conductive thin film formed on the side end surface of the insulating layer from below; forming plating resists by removing unexposed portions of the photoresists so as to form exposed portions into patterns; forming an end portion conductive layer on the end portion of the conductive thin film formed on the upper surface of the insulating layer, and forming the conductive layer on the conductive thin film formed on the upper surface of the insulating thin film at the same time, on the conductive thin films exposed from the plating resists,; removing the plating resists; and removing the conductive thin films having been covered with the plating resists. | 2009-10-22 |
20090263749 | METHOD OF FORMING FINE PATTERNS OF SEMICONDUCTOR DEVICE - A method of forming fine patterns of a semiconductor device, in which a plurality of conductive lines formed in a cell array region are integrally formed with contact pads for connecting the conductive lines to a peripheral circuit. In this method, a plurality of mold mask patterns, each including a first portion extending in a first direction and a second portion which is integrally formed with the first portion and extends in a second direction, are formed within a cell block on a substrate comprising a film which is to be etched. A first mask layer covering sidewalls and an upper surface of each of the plurality of mold mask patterns is formed on the substrate. First mask patterns are formed by partially removing the first mask layer so that a first area of the first mask layer remains and a second area of the first mask layer is removed. The first area of the first mask layer covers sidewalls of adjacent mold mask patterns from among the plurality of mold mask patterns by being located between the adjacent mold mask patterns, and the second area of the first mask layer covers portions of the sidewalls of the plurality of mold mask patterns, the portions corresponding to an outermost sidewall of a mold mask pattern block. | 2009-10-22 |
20090263750 | FOREIGN PARTICLE INSPECTION APPARATUS, EXPOSURE APPARATUS, AND METHOD OF MANUFACTURING DEVICE - A foreign particle inspection apparatus includes a light projecting unit, a photo-receiving unit which receives the scattered light, and a. The photo-receiving unit is arranged such that its optical axis is tilted by a first angle with respect to a plane including the optical axis and the normal axis to the surface. When the angle of the polarization axis of the projected light with respect to the plane is defined as a second angle, the controller controls at least one of the polarization axis and the arrangement of the photo-receiving unit so that the differences between the first angle and the second angle become a first state and a second state, thereby determining a foreign particle based on the outputs from the photo-receiving unit in the first state and the second state. | 2009-10-22 |
20090263751 | Methods for double patterning photoresist - Embodiments of methods for double patterning photoresist are generally described herein. Other embodiments may be described and claimed. | 2009-10-22 |
20090263752 | METHOD AND DEVICE FOR COMBUSTION OF SOLID PHASE FUEL - Method for combusting a solid phase fuel, where the fuel is caused, by the help of a non-pneumatic feeding element ( | 2009-10-22 |
20090263753 | RADIANT TUBE WITH RECIRCULATION - A burner fires into a radiant tube to provide a downstream flow of combustion products within the radiant tube. Staged fuel is injected upstream into the radiant tube. A recirculation conduit inside the radiant tube receives the staged fuel along with combustion products that are inspirated into the recirculation conduit by the staged fuel. The recirculation conduit has an outlet for discharging a mixture of the inspirated combustion products and staged fuel into the downstream flow of combustion products. | 2009-10-22 |
20090263754 | Utility light with illumination arrangement - A utility lighter includes a lighter casing having a casing body and an extension arm, a gas releasing valve provided in the lighter casing, an ignition nozzle provided at an upper end of the extension arm to communicate with the gas releasing valve; a piezoelectric unit, an actuation unit and an illumination arrangement. The illumination arrangement includes an illumination holder mounted on the lighter casing; and an illumination unit mounted on the illumination holder, in such a manner that the illumination unit is arranged to provide illumination primarily toward the ignition zone so that a user is able to accurately apply the ignition of the utility lighter to a target spot as clearly visualized by illumination of the ignition zone. | 2009-10-22 |
20090263755 | Off-gas flare - An off-gas flare system for disposing of a waste gas stream containing BTEX and VOC contaminants, and for safely handling slugs of excess liquids entrained in the waste gas stream. The flare system includes a flare stack, an enclosed steam tank disposed within the flare stack for receiving the waste gas stream and vaporizing any liquids in the waste gas stream into vapors, and an enclosed liquid tank disposed below the steam tank and in fluid communication with the steam tank for receiving the heated waste gas and liquid vapors and for temporarily containing any excess non-vaporized liquids. The flare also includes a waste gas burner disposed in the flare stack adjacent the steam tank and in fluid communication with the liquid tank, and a continuous means for igniting the waste gas burner. | 2009-10-22 |
20090263756 | CANDLE WITH WATER IN WAX - A method for producing a candle shaped from a wax, wherein a dispersion of water droplets is purposely added within the wax. | 2009-10-22 |
20090263757 | WALL STRUCTURE AND BURNER AS WELL AS SYSTEM - A wall structure ( | 2009-10-22 |
20090263758 | METHOD AND CONTINUOUS FURNACE FOR HEATING WORKPIECES - There is provided a system and method for heating at least one workpiece in a furnace by which the workpiece is heated by heating facilities. An exemplary method comprises heating a complete workpiece with the heating facilities. The exemplary method also comprises moving the workpiece out of the furnace such that a first portion of the workpiece is still inside the furnace while a second portion of the workpiece is outside the furnace and holding the workpiece at this position for a predetermined time period. Finally, the exemplary method comprises moving the complete workpiece out of the furnace. | 2009-10-22 |
20090263759 | METHOD AND APPARATUS FOR DETECTING ABNORMALITY IN TOOTH STRUCTURE - An illuminating radiation beam is directed toward a potentially or actually carious structure (particularly a tooth). A detector detects acoustic oscillations set up in the structure resultant from the illuminating radiation and produces an output signal dependent upon the magnitude of the oscillations detected. Signals from the detector are processed to predict the presence or magnitude of carious infection of the structure. | 2009-10-22 |
20090263760 | ABUTMENT FOR IMPLANT - In an abutment for a dental implant which includes a crown connection part, a smooth tissue contact part and a fixture engaging part, there is provided an improved abutment for a dental implant characterized in that only the smooth tissue contact part is coated. The abutment is made of titanium. The coating process is performed with TiN. | 2009-10-22 |
20090263761 | DENTURE ABUTMENT AND RETENTION SYSTEM - A denture retention system includes a denture and an abutment. The denture has an inner channel with an elastic liner having shaped cavities. The cavities have a shaft, a radially outwardly extending ledge surface at the inner end of the shaft and an opening at the outer end of the shaft. The abutment has a shaft portion, a head portion at one end of the shaft portion and a threaded portion at the other end of the shaft portion. The head portion has an undercut surface that extends radially outwardly from the shaft portion. The ledge surface and undercut surfaces overlap and engage one another to retain the denture in the cavity. The threaded part of the abutment threads into an implant or implants into a jaw. The cavity expands when the abutment is inserted or removed from the cavity, and contracts after insertion. | 2009-10-22 |
20090263762 | DENTURE ABUTMENT & RETENTION SYSTEM - A denture retention system includes a denture and an abutment. The denture has an inner channel with an elastic liner having shaped cavities. The cavities have a shaft, a head at the closed end of the shaft and a concave ring between two convex sections on the shaft. The abutment has a shaft, a head at one end of the shaft, a protruding ring between two concave sections on the shaft and a threaded portion at the other end of the shaft portion. The surface of the cavity overlaps and engages the surface of the abutment to retain the denture in the cavity. The threaded part of the abutment threads into an implant or implants into a jaw. The cavity expands when the abutment is inserted or removed from the cavity, and contracts after insertion. | 2009-10-22 |
20090263763 | Denture Abutment & Retention System - A denture retention system includes a denture and an abutment. The denture has an inner channel with an elastic liner having inserts. Each insert has an O-ring and a channel for capturing the O-ring. The abutment has a shaft, a head at one end of the shaft and a base at the other end of the shaft. The head has an undercut surface that extends radially outwardly from the shaft. The O-ring and undercut surface overlap and engage one another to retain the denture in the cavity. The abutment has a threaded portion at the other end of the shaft portion that threads into an implant or implants into a jaw, or a threaded aperture that receives a threaded portion on an implant. | 2009-10-22 |
20090263764 | METHOD FOR PRE-OPERATIVE VISUALIZATION OF INSTRUMENTATION USED WITH A SURGICAL GUIDE FOR DENTAL IMPLANT PLACEMENT - The invention relates to manufacturing a surgical guide to be placed in a patient's mouth. The patient's mouth is scanned to obtain surgical-region scan data at a region where an implant is to be located. The patient's mouth is also scanned in the opened position to acquire dental conditions opposite from the surgical region so as to obtain opposing-condition scan data. A virtual model is developed using the surgical-region scan data and the opposing-condition scan data. Using the virtual model, a surgical plan is developed that includes the location of the implant to be installed in the patient. A virtual surgical guide is also developed based on the surgical plan. The dimensions of instrumentation to be used with the surgical guide are checked to ensure they will fit within the mouth by use of the opposing-condition scan data. After checking, final surgical-guide manufacturing information is obtained for manufacturing the surgical guide. | 2009-10-22 |
20090263765 | METHODS AND APPARATUS TO PROVIDE TRAINING AGAINST IMPROVISED EXPLOSIVE DEVICES - Method and apparatus for a training system for improvised explosive devices (IEDs). An IED training system can include an inert explosive component that can resemble a large round, rocket propelled grenade (RPG), or the like. Various triggers can activate visual and/or audio devices in response to triggering the system, such as by a motion sensor or trainer action. | 2009-10-22 |
20090263766 | STYLING HANDS - The present disclosure provides toy sets which incorporate at least one manikin hand configured to removably secure one or more artificial fingernails so that they can be decorated. | 2009-10-22 |
20090263767 | Method for Charting Astrological Events - A method of charting astrological events comprises the steps of obtaining a user's date of interest which is often a birthdate and using the date to chart the position of celestial objects at the date of interest on an astrological chart divided into 12 equal segments. The user selects a celestial object of interest such as Mercury etc. and rotates the alignment until the object is on the zero point. The user then looks at specific angles called crucial points or secondary crucial points which coincide with 45 degree increments from the zero point. Crucial events are determined by the presence of celestial objects such as the Sun or Moon appearing in those crucial points. The method is repeated for another celestial object of interest by rotating until the other celestial object is at the zero point. In one embodiment, a computer is used to calculate and rotate the chart. | 2009-10-22 |
20090263768 | Generating An Optimized Analytical Business Transformation - A method, system, and computer program product for optimizing a Business Process Model (BPM) having at least one work process are presented. At a simulation client, a determination is made whether a simulated business outcome associated with a test BPM satisfies a business value deficiency associated with a current BPM. In response to a determination that the simulated business outcome does not satisfy the business value deficiency, the test BPM is optimized. Once the simulation client determines that the simulated business outcome satisfies the business value deficiency, the test BPM is implemented as an actual BPM. Moreover, an actual business outcome associated with the actual BPM is generated. A determination is made whether the actual business outcome satisfies the simulated business outcome. In response to a determination that the actual business outcome does not satisfy the simulated business outcome, the actual BPM is optimized. | 2009-10-22 |
20090263769 | METHOD AND SYSTEM FOR ARRANGING AND DISPLAYING PROJECT MANAGEMENT INTELLIGENCE - A method and system for arranging, displaying, conveying, learning, and communicating project management intelligence utilizes a device formed of a plurality of 3-dimensional geometric polytopes movably connected together and movable relative to one another. The polytopes represent the domain of project knowledge, the domain of project process groups, and the domain of project management competency, respectively and each polytope has surfaces or sections bearing indicia representing clusters of functional information and aspects of project management relative to the respective project management intelligence domain. The polytopes are manipulated individually to align selected surfaces or sections of each polytope relative to one another so as to collectively visually display selected combinations of interrelated and conjoined functional information and aspects of project management intelligence within the domains. | 2009-10-22 |
20090263770 | SYSTEM AND METHOD FOR SIMULATING HAZARDOUS ENVIRONMENTS FOR PORTABLE DETECTION METERS USED BY FIRST RESPONDERS - The system and method for simulating hazardous environments provides simulated meter readings of hazardous environment for training first responder entry teams by controlling a simulated display provided to portable detection meters, such as via a wireless interface. The simulator provides meter reading displays for selected environments and allows for two-way interactive response. A master control unit allows direct control of individual meter displays and scenarios representing various hazardous environments. A hazardous environment is reflected by parameters indicating the presence of hazardous substances, and the apparatus can be implemented by external placement on current meters, as part of a general training meter, or using technology to internally control existing meters. | 2009-10-22 |
20090263771 | CONTAMINATION DETECTION SIMULATION SYSTEMS AND METHODS - Provided are contamination detection simulation systems and methods comprising a control unit that generates a first signal comprising data corresponding to a simulated source of contamination; a simulated detector that receives the signal from the control unit, the simulated detector positioned at a distance from a surface; a proximity detector that determines the distance between the simulated detector and the surface and outputs a distance result; and a processing unit that generates a second signal in response to the first signal and the distance result. | 2009-10-22 |
20090263772 | Physical education system - A method for group teaching of physical activity. The method includes: selecting a video, wherein the video displays instructions for at least one physical activity; assembling selected exercise equipment, wherein the exercise equipment is selected based on the instructions displayed in the video and a number of participants in the group; positioning the exercise equipment in selected positions, wherein the exercise equipment is positioned based on the instructions displayed in the video; assigning participants to stations, wherein the participants are assigned to the stations based on the instructions displayed in the video; playing the video, wherein the participants are instructed to participate in the at least one physical activity by following the instructions displayed in the video; and monitoring compliance, technique, and condition of the participants as the participants perform aspects of the at least one physical activity. The physical fitness of the participants is improved by performance of the at least one physical activity. | 2009-10-22 |
20090263773 | BREATHING EXERCISE APPARATUS AND METHOD - A breathing exercise apparatus includes (a) a graphical display, (b) input elements for receiving from a user durations for inhalation, exhalation and pause phases of a breathing exercise pattern; and (c) a controller for causing the graphical display to display a sequence of graphical images according to the received durations for the inhalation, the exhalation and the pause phases of the breathing exercise pattern. The breathing exercise apparatus may be implemented on a personal computer by providing on a computer-readable medium instructions executable by the computer that carry out the method which includes (a) receiving from a user durations for inhalation, exhalation and pause phases of a breathing exercise pattern; and (b) displaying on a graphical display a sequence of graphical images according to the received durations for the inhalation, the exhalation and the pause phases of the breathing exercise pattern. In one embodiment, the inhalation phase, the exhalation phase and the pause phase may each be specified more than once and may be arranged in any order the user desired, thereby providing the building blocks for constructing any and practically all possible breathing exercises. | 2009-10-22 |
20090263774 | Radiopaque Artificial Tooth - An artificial tooth is provided that mimic the essential features of natural a tooth for use in training dental professionals. The artificial tooth is a radiopaque artificial tooth that is capable of providing for anatomically correct contrast on a radiograph. The artificial tooth also mimics the hardness, debris characteristics, and anatomical features of a natural tooth. A dental training device is also provided that includes a support structure generally configured as a mouth or jaw that supports radiopaque artificial teeth. | 2009-10-22 |
20090263775 | Systems and Methods for Surgical Simulation and Training - A surgical simulation and training platform can mimic human physiology to the extent possible, while enabling dynamic pathology and complication introduction to facilitate training and evaluation needs. The platform can include a subject body having an outer surface and defining at least one cavity, with a capture mechanism configured to receive an instrument and mounted to a robotic positioning assembly within the cavity. The system can further include one or more sensors configured to determine the position of at least one instrument or provide data for determining the position, and a processor. The processor can receive data indicating a position of at least one instrument relative to the cavity in a subject body and provide a command to the robotic positioning assembly to adjust the position of the capture mechanism to encounter and engage the instrument during surgical simulation. | 2009-10-22 |
20090263776 | Course Development Program - The present invention is directed to a method of operating a knowledge capture program. The knowledge capture program has the steps of starting the knowledge capture program wherein a user can access content that is either existing content or creating new content. Once the content has been selected then a source subject matter can be selected and displayed, and then captured and incorporated into the content. The source subject matter can be edited and saved into the content. The content can then be retrieved and played in a desired mode of learning. | 2009-10-22 |
20090263777 | Immersive interactive environment for asynchronous learning and entertainment - The present immersive interactive environment for asynchronous learning and entertainment enables customization a lesson embodied in at least one lesson data file residing on a computing device. This is accomplished by providing a lesson data file-editing program embodied in at least one sequence of computer executable instructions to an instructor by allowing the instructor to execute the editing program via a computing device in order to customize a lesson data file. The instructor is also provided with at least one general lesson data file via said computing device. The instructor is thus able to customize the general lesson data file via said editing program to create a customized lesson, the customized lesson being embodied in at least one customized lesson data file residing on said computing device. A student will thus be capable of accessing said at least one customized lesson data file via a lesson presentation program embodied in at least one sequence of computer executable instructions and thereby able to perceive the customized lesson. | 2009-10-22 |
20090263778 | System and Method For Real-Time Observation Assessment - Techniques for real-time observation assessment are provided. The techniques, which are designed for educators, take advantage of handheld computers, desktop/laptop computers and Internet access in order to reduce the paperwork associated with conventional educational assessments. An array of instructional assessment applications are designed to run on handheld computers. The instructional assessment applications may be based on existing and widely used paper methodologies. A common Web-based platform for assessment application distribution, selection, download, data management and reporting is also provided. Users can then periodically synchronize instructional data (assessments, diagnostic results, notes and/or schedules) to the Web site. At the Web site, browser-based reports and analysis can be viewed, administered and shared via electronic mail. | 2009-10-22 |
20090263779 | METHOD AND SYSTEM OF PROVIDING A COLLEGE LEVEL COURSE FROM A THIRD PARTY PROVIDER TO A COLLEGE - The present invention relates to a system and method of providing a college level course from a third party provider to a college. The present invention allows the college to offer the course to its students as if the course was produced and offered by the college itself rather than the third party provider. The course is preapproved and then the college can provide the student grades from the third party provider as if the course was a regular course from the college. | 2009-10-22 |
20090263780 | Organ preservation fluid - Novel organ preservation fluids, as well as related articles and methods, are disclosed. | 2009-10-22 |
20090263781 | Composition for Preserving Platelets and Method of Using the Same - The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state. | 2009-10-22 |
20090263782 | Reaction apparatus - An apparatus | 2009-10-22 |
20090263783 | NUCLEIC SEQUENCE AND DEDUCED PROTEIN SEQUENCE FAMILY WITH HUMAN ENDOGENOUS RETROVIRAL MOTIFS, AND THEIR USES - The present invention provides a translational product encoded by the nucleotide sequence of SEQ ID NO: 2, which corresponds to the gag gene of an endogenous human retrovirus named HERV-7q. The present invention also provides methods for diagnosing a neurological or autoimmune disease in a patient. | 2009-10-22 |
20090263784 | THREE-DIMENSIONAL STRUCTURE OF PROSTAGLANDIN D SYNTHASE AND UTILIZATION THEREOF - A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D | 2009-10-22 |
20090263785 | Modified HIV-1 Peptides and Use Thereof in the Detection of Anit-HIV Antibodies - The invention relates to synthetic peptides having sequence (III), which are derived from HIV-1 virus gp41 and which can be used in immunoassays for the detection of infections caused by HIV-1 viruses. The invention also relates to the method of preparing said peptides, to compositions and kits containing same and to the use thereof for diagnostic purposes. The invention further relates to immunoassays which use said peptides for the detection of anti-HIV virus antibodies. | 2009-10-22 |
20090263786 | Mass spectrometric analysis method - Methods of using mass spectrometry and in particular matrix assisted laser Ligand-Complex from Target and desorption-ionization (MALDI) mass spectrometry to analyze, or otherwise detect the presence of or determine the identity of intact ions of undigested, unfragmented covalently stabilized supramolecular target-ligand-complexes, as well as the use of these methods in various biological application such as characterization of antibodies, drug discovery, and complexomics including automated or higher throughput applications. | 2009-10-22 |
20090263787 | METHOD FOR SCREENING OF INFECTIOUS AGENTS IN BLOOD - This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the screening of infectious agents in blood. | 2009-10-22 |
20090263788 | EFFICIENT ALGORITHM FOR PCR TESTING OF BLOOD SAMPLES - Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. Samples are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, X | 2009-10-22 |
20090263789 | Method for Detecting Nucleic Acid Sequences - The invention is directed to a method for detecting a target nucleic acid sequence by non-linear amplification. | 2009-10-22 |
20090263790 | Methods for Identifying Functionally Related Genes and Drug Targets - The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described. Effective targets are useful for treating a disease, condition or disorder associated with the physiological pathway. | 2009-10-22 |
20090263791 | Chemically Cleavable 3'-O-Allyl-DNTP-Allyl-Fluorophore Fluorescent Nucleotide Analogues and Related Methods - This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue. | 2009-10-22 |
20090263792 | ATOPIC DERMATITIS MARKER AND TECHNIQUE OF USING THE SAME - It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein the specific proteins change their expression with inflammation caused by atopic dermatitis or change their expression according to the degree of predisposition to atopic dermatitis. The present invention also provides a kit for determining the degree of inflammation of atopic dermatitis or risk of developing atopic dermatitis, as well as a method for determining substances effective in the treatment and/or prevention of atopic dermatitis. | 2009-10-22 |
20090263793 | NOVEL METHOD FOR DIAGNOSING OF MYCOBACTERIUM Tuberculosis - The present invention relates to a method and a kit for detecting | 2009-10-22 |
20090263794 | High Throughput Flow Through Sample Preparation Using Magnetic Beads - A polymerase chain reaction system for analyzing a sample containing nucleic acid includes providing magnetic beads; providing a flow channel having a polymerase chain reaction chamber, a pre polymerase chain reaction magnet position adjacent the polymerase chain reaction chamber, and a post pre polymerase magnet position adjacent the polymerase chain reaction chamber. The nucleic acid is bound to the magnetic beads. The magnetic beads with the nucleic acid flow to the pre polymerase chain reaction magnet position in the flow channel. The magnetic beads and the nucleic acid are washed with ethanol. The nucleic acid in the polymerase chain reaction chamber is amplified. The magnetic beads and the nucleic acid are separated into a waste stream containing the magnetic beads and a post polymerase chain reaction mix containing the nucleic acid. The reaction mix containing the nucleic acid flows to an analysis unit in the channel for analysis. | 2009-10-22 |
20090263795 | DIAGNOSTIC METHODS INVOLVING DETERMINING GENE COPY NUMBERS AND SNPs IN THE FcyRII/FcyRIII GENE CLUSTER, AND PROBES FOR USE IN SUCH METHODS TO DETECT SUSCEPTIBILITY TO AND TREATMENT EFFICACY IN AUTOIMMUNE DISEASES - The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from said subject the amount of intact genes, or gene products thereof, of the FcγRII/FcγRIII gene cluster, said gene cluster comprising the FCGR2C, FCGR3A, FCGR2A and FCGR3B genes encoding an activating FcγR, and FCGR2B encoding an inhibitory Fcγ R; and correlating said amount to the amount observed in a healthy population. Also provided is a method to predict the responsiveness of a subject to therapy with intravenous immunoglobulin (IVIg) therapy or a monospecific biological, such as a humanized or human monoclonal antibody or a chimeric molecule, comprising the C-terminal Fc-tail of IgG. | 2009-10-22 |
20090263796 | METHODS AND COMPOSITIONS FOR DIAGNOSING OR MONITORING AUTOIMMUNE AND CHRONIC INFLAMMATORY DISEASES - Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described. | 2009-10-22 |
20090263797 | REVERSIBLE DI-NUCLEOTIDE TERMINATOR SEQUENCING - The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some embodiments, the di-nucleotides do not contain conventional nucleotide triphosphates, but rather employ amino acid phosphoramidate nucleotides (AAPNs). | 2009-10-22 |
20090263798 | Method For Identification Of Novel Physical Linkage Of Genomic Sequences - The invention is directed to methods to identify the location in a genome of a nonfixed or multicopy genomic element using microarrays or sequencing. | 2009-10-22 |
20090263799 | ASSAY FOR PROSTATE CANCER - In certain embodiments, a method for detecting a prostate proliferative cell disorder, a prostate cancer or a prostate tumor and/or categorizing Gleason's Sum of the tumors includes performing a digital rectal examination on a subject; obtaining one or more expressed prostatic secretion (EPS) samples from the subject; measuring PSA levels in the EPS; and measuring a biomarker, wherein the biomarker is TMPRSS2:ERG fusion RNA. Optionally, the biomarker may be methylated copies of GSTPI, APC, RARB and/or RASSFI DNA or PCA3 RNA. A kit for performing any of the above embodiments is also contemplated. | 2009-10-22 |
20090263800 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION - Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described. | 2009-10-22 |
20090263801 | Phenotype-Genotype Relationship in Age-Related Macular Degeneration - Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate. | 2009-10-22 |
20090263802 | Methods and compositions for efficient base calling in sequencing reactions - The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences. In particular, the present invention provides methods and compositions for improving the efficiency of sequencing reactions by using fewer labels to distinguish between nucleotides and by detecting nucleotides at multiple detection positions in a target sequence. | 2009-10-22 |
20090263803 | MIRNAS DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS - The present invention provides diagnostics and/or prognostic methods by identifying miRNAs that are differentially expressed or mis-regulated in various states of diseased, normal, cancerous, and/or abnormal tissues, including but not limited to cervix, skin, colon, breast, bladder, esophagus, liver, ovary, prostate, lung, pancreas, thyroid, kidney, stomach, testicle, uterus, spleen, tongue, brain, thymus, trachea and/or small intestine. In certain apsects, differential miRNA expression is initially determined by comparing miRNA expression between a normal tissue and cancer negative lymph node (LNneg), a normal tissue and a cancer positive lymph node (LNpos), a cancerous tissue and LNneg and/or LNpos, LNneg and LNpos. The methods of the invention are used to identify the presence or absence of non-lymphoid cells from other organs or tissues, and/or metastatic cancer cells present in lymph nodes. | 2009-10-22 |
20090263804 | Biomarkers for aging - A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and/or cognitive decline. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease. | 2009-10-22 |
20090263805 | Methods of identifying point mutations in a genome that affect the risk for or the age of appearance of disease - The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutations are identified directly by a method of recognition using the set of point mutations observed in a large population of juveniles. Harmful mutations are identified by comparison of the set of point mutation observed in a large set of juveniles and a large set of aged individuals of the same population. Beneficial mutations are similarly identified. | 2009-10-22 |
20090263806 | Method for detecting chikungunya virus - Compositions, methods and kits for detecting Chikungunya viral nucleic acids. Particularly described are methods for detecting very low levels of the viral nucleic acids using nucleic acid amplification. | 2009-10-22 |
20090263807 | OPTICAL DETECTION FIELD HAVING DIAMOND-LIKE CARBON THIN FILM FORMED THEREIN - An optical detection field, wherein a diamond-like carbon thin film containing therein fluorine is formed on a surface facing an existence region of a substance. | 2009-10-22 |
20090263808 | Genetic Analysis For Stratification of Cancer Risk - The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal history measures such as age and race are used to further refine the analysis. Using such methods, it is possible to reallocate healthcare costs in cancer screening to patient subpopulations at increased cancer risk. It also permits identification of candidates for cancer prophylactic treatment. | 2009-10-22 |
20090263809 | Methods for Identification of Bioagents - Methods for detecting and identifying known and unknown bioagents, particularly bacteria, by nucleic acid amplification and amplicon size determination are provided. Nucleic acid amplification utilises multiple primers which hybridize to conserved bioagent ribosomal sequence regions and which bracket variable bioagent ribosomal sequence regions to produce multiple amplicons that uniquely identify the bioagent. | 2009-10-22 |
20090263810 | BISULFITE CONVERSION OF DNA - The present invention provides an improved method for the bisulfite conversion of DNA, and facilitates the analysis of cytosine methylation of genomic DNA. Novel combinations of denaturing solvents, new reaction conditions and new purification methods provide surprisingly efficacious methods for bisulfite conversion of DNA relative to prior art methods. The converted DNA may subsequently be analyzed by many different methods. | 2009-10-22 |
20090263811 | TARGET BASE DISCRIMINATION METHOD - A target base-specific primer for use in discrimination of the base type of a target base in a nucleic acid in a nucleic acid sample, which is capable of discriminating the target base clearly with less possibility of false positive, and a target base discrimination method using the target base-specific primer, are provided. The target base discrimination method of the present invention uses a target base-specific primer for use in discrimination of the base type of a target base in a nucleic acid having a target nucleotide sequence including the target base in a nucleic acid sample, in the case where a plurality of base types can be enumerated for the target base, wherein the primer has a target base-corresponding base which is a base complementary to a base predicted as the target base, and the base type of a mismatch base is a specific base type when the mismatch base refers to a base adjacent to the 5′ side of the target base-corresponding base, and a mismatch-corresponding base refers to a base adjacent to the 3′ side of the target base in the target nucleotide sequence. | 2009-10-22 |
20090263812 | USE OF ID4 FOR DIAGNOSIS AND TREATMENT OF CANCER - The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed are a method of analyzing the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a pancreatic cancer cell, and a method of inhibiting the methylation of an ID4 gene promoter or enhancing the expression of an ID4 gene by contacting a pancreatic cancer cell with a compound that decreases the methylation level of an ID4 gene promoter or increases the expression level of an ID4 gene in the cell. | 2009-10-22 |
20090263813 | RIBONUCLEOTIDE TAG NUCLEIC ACID DETECTION - The present application provides polynucleotides comprising 5′-tails with sequence segments useful for the detection of target nucleic acid sequences, and methods for their use in detecting target nucleic acids. The polynucleotides are used to amplify a subsequence of a target nucleic acid in the presence of one or more ribonucleotides. The ribonucleotides are incorporated into amplification products at regular intervals complementary to the 5′-tail sequence segments. Cleavage of amplification products at the bond immediately 3′ to incorporated ribonucleotides produces detectably distinct fragments indicative of the presence or absence of a target nucleic acid. | 2009-10-22 |
20090263814 | Physiogenomic Method for Predicting Metabolic and Cardiovascular Side Effects of Thiazolidinediones - Disclosed herein are genetic markers related to the efficacy and/or safety of thiazolidinedione therapy identified by a physiogenomic methodology that correlates the genetic markers with a physiological response. The genetic markers described herein were not previously associated with the efficacy and/or safety of thiazolidinedione therapy. The markers related to safety are those associated with the important side effects of BMI increase and development of edema. In one embodiment, markers related to efficacy of thiazolidinedione therapy are associated with glycosylated hemoglobin. Method of assessing an individual for markers associated with the safety and/or efficacy of thiazolidinedione therapy are described. | 2009-10-22 |
20090263815 | CELL CULTURE SYSTEM, PROCESS FOR THE PRODUCTION THEREOF, AND THE USE THEREOF IN PRECLINICAL INVESTIGATION - The invention relates to a cell culture system, in particular for the preclinical testing of active substances, comprising a first and a second compartment which are in communication with one another via a separating layer between the first and the second compartment, the separation layer being permeable for cellularly secreted substances, wherein the first compartment includes a syntopic culture with tissue cells and immune cells and the second compartment includes a culture with blood cells. The invention further relates to a method in this regard and to a kit and uses for the preclinical testing of active substances. | 2009-10-22 |
20090263816 | LABELLED BEADS - A labelled polymeric bead wherein individual beads comprise a primary particle formed of a synthetic polymeric material, and at least one secondary particle entrapped within the primary particle of the bead and being comprised of a synthetic polymer material incorporating reporter moieties. | 2009-10-22 |
20090263817 | METHODS FOR DIAGNOSING AND TREATING SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE AND COMPOSITIONS THEREOF - The present invention is directed to novel methods for diagnosis and prognosis of Systemic lupus erythematosus by identifying differentially expressed genes. Moreover, the present invention is also directed to methods that can be used to screen test compounds and therapies for the ability to inhibit systemic lupus erythematosus. Additionally, methods and molecule targets (genes and their products) for therapeutic intervention in systemic lupus erythematosus are described. | 2009-10-22 |
20090263818 | Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by UGT1A1 enzyme or whose metabolic intermediate is metabolized by the enzyme - A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan, and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive sequences in the promoter region of UGT1 gene and two types of polymorphisms (bases at the 211- and 686-positions) on the basis of single nucleotide polymorphisms in the exon 1 are analyzed. Based on the analytical data, the risk of the expression of an adverse drug reaction caused by the administration of irinotecan is estimated. Further, the administration doses of irinotecan is designed for individual patients depending on the risk of the expression of the adverse drub reaction, thereby reducing the adverse drug reaction caused by the administration of irinotecan. | 2009-10-22 |
20090263819 | GENE AND PROTEIN EXPRESSION PROFILES ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF EGFR-TK INHIBITORS - The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders. The present invention further provide methods of using the gene and protein expression profiles, and assays for identifying the presence of a gene or protein expression profile in a patient sample. | 2009-10-22 |
20090263820 | Optimization of Gene Expression Analysis using Immobilized Capture Probes - Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label. | 2009-10-22 |
20090263821 | Ubiquitin Ligase Assays And Related Reagents - The disclosure provides, inter alia, methods and reagents for use in measuring the attachment of ubiquitin and ubiquitin-like proteins to a target protein, particularly an E3 protein. | 2009-10-22 |