42nd week of 2011 patent applcation highlights part 49 |
Patent application number | Title | Published |
20110257341 | Postcrosslinking of Water-Absorbing Polymers - The invention concerns a process for producing water-absorbing polymer, which comprises a base polymer A being mixed with a first aqueous solution B of at least one surface postcrosslinker and a second aqueous solution C of at least one polyvalent cation and thermally treated, wherein said base polymer A is based on at least 50% neutralized acid-functional monomer and said solutions B and C are metered wholly or partly concurrently through separate nozzles whereby a water-absorbing polymer having a high saline flow conductivity value is obtained. | 2011-10-20 |
20110257342 | COMMON SOLVENT PROCESS FOR PRODUCING HIGH MOLECULAR WEIGHT HALOBUTYL RUBBER - An integrated process for the solution polymerization and subsequent halogenation of butyl rubber in a common medium is disclosed. The process comprises providing a solution polymerization reactor containing a C6 medium mixed with a monomer mixture comprising at least an isoolefin monomer and a multiolefin monomer in a mass ratio of monomer mixture to medium of from 61:39 to 80:20. Once polymerized, residual unreacted monomer mixture is separated from the rubber solution using a distillation process. The residual monomers may then be purified and recycled back into the reactor. The separated rubber solution is then halogenated. The process obviates the need for separating the rubber from the medium following polymerization, then re-dissolving it in another solvent for halogenation, thereby saving energy cost. The process optionally employs heat exchangers for the reactor feed streams to further reduce energy consumption. | 2011-10-20 |
20110257343 | Multifunctional Degradable Nanoparticles with Control over Size and Functionalities - In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymer and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2011-10-20 |
20110257344 | THERMALLY REVERSIBLE CROSS-LINKED POLY(ARYL ETHER KETONE) MEDIA AND METHOD FOR HIGH DENSITY DATA STORAGE - A composition of matter for a recording medium in atomic force data storage devices. The composition includes one or more poly(aryl ether ketone) copolymers, each of the one or more poly(aryl ether ketone) copolymers including (a) a first monomer including an aryl ether ketone and (b) a second monomer including an aryl ether ketone and a hydrogen bonding cross-linking moiety, the moiety capable of forming two or more hydrogen bonds at room temperature, each of the one or more poly(aryl ether ketone) copolymers having two terminal ends, each terminal end having a phenylethynyl moiety. The covalent and hydrogen bonding cross-linking of the poly(aryl ether ketone) oligomers may be tuned to match thermal and force parameters required in read-write-erase cycles. | 2011-10-20 |
20110257345 | METHOD OF SEPARATING AND CLEANING OF POST CONSUMER CARPET FACE YARN FROM CARPET BACKING AND YARN PRODUCT PRODUCED THEREFROM - A process for producing a synthetic fiber composition with reclaimed post consumer carpet yarn, wherein face yarn is shaved from post consumer carpet using a shaving device to provide shaved face yarn, the shaved face yarn is reduced in size, contaminants are removed using mechanical screeners, the shaved face yarn is melt filtered, and spun into fiber. | 2011-10-20 |
20110257346 | Polyester Ethers Derived From Asymmetrical Monomers Based Upon Bisanydrohexitols - Asymmetrically substituted compounds of bisanhydrohexitols are described, including the bisanhydrohexitol isosorbide. The compounds are useful as monomers. The synthesis of polymers from the monomers is also described. | 2011-10-20 |
20110257347 | Phosphorus-containing benzoxazine-based bisphenols, derivatives thereof, and preparing method for the same - Phosphorus-containing benzoxazine-based bisphenols and derivatives thereof are disclosed. The phosphorus-containing benzoxazine-based bisphenols are prepared by reacting DOPO with benzoxazine to form the phosphorus-containing benzoxazine-based bisphenols. The phosphorus-containing benzoxazine-based bisphenols can further to form advanced epoxy resins. The advanced epoxy resins can further be cured to form flame retardant epoxy thermosets. | 2011-10-20 |
20110257348 | CATALYST COMPOSITIONS FOR PRODUCING HIGH Mz/Mw POLYOLEFINS - The present invention provides a polymerization process utilizing a dual ansa-metallocene catalyst system. Polymers produced from the polymerization process are also provided, and these polymers have a reverse comonomer distribution, a non-bimodal molecular weight distribution, a ratio of Mw/Mn from about 3 to about 8, and a ratio of Mz/Mw from about 3 to about 6. | 2011-10-20 |
20110257349 | APPARATUS FOR HEAT TREATMENT OF POLYESTER PARTICLE AND METHOD OF MULTISTAGE SOLID-PHASE POLYCONDENSATION OF POLYESTER PARTICLE - A multistage method for solid-phase polycondensation of polyester particles, comprising continuous polycondensation in: (1) a first fluidized bed; (2) a first moving bed; (3) a second fluidized bed; and (4) a second moving bed in the stated order along a flow of the particles, wherein the second moving bed has a capacity twice or more as large as a capacity of the first moving bed, is provided. | 2011-10-20 |
20110257350 | Polymer mitigation - Ethylene is selectively oligomerized in a continuously stirred tank reactor (CSTR) that is preferably operated in an isothermal manner using a chromium catalyst. The undesired formation of by-product polyethylene is mitigated by contacting the ethylene with hydrogen prior to adding the ethylene to the reactor and feeding the ethylene and hydrogen via a common feed port. | 2011-10-20 |
20110257351 | NOVEL TRIARYLPHOSPHINE OR TRIARYLARSINE COMPOUND, ALPHA-OLEFIN POLYMERIZATION CATALYST USING THE COMPOUND, TERNARY COPOLYMER, AND PRODUCTION PROCESS OF ALPHA-OLEFIN -((METH)ACRYLIC ACID)-BASED COPOLYMER - To provide an industrially useful α-olefin.((meth)acrylic acid)-based olefin copolymer having both a high molecular weight and a high comonomer content, a catalyst component capable of realizing a production of two different kinds of α-olefin.((meth)acrylic acid)-based olefin copolymers, and a production process using the catalyst. An α-olefin.((meth)acrylic acid)-based olefin copolymer is produced by using a metal complex complexed with a ligand represented by the following formula (Y is phosphorus or arsenic) for a catalyst composition. | 2011-10-20 |
20110257352 | Amino phosphine - A new P-N-P ligand in which each phosphorus atom is bonded to two ortho-fluorine substituted phenyl groups is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions. | 2011-10-20 |
20110257353 | POLYMER PRECURSORS OF RADIOLABELED COMPOUNDS, AND METHODS OF MAKING AND USING THE SAME - One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds. | 2011-10-20 |
20110257354 | FINE PARTICLES AND METHOD OF PRODUCING THEREOF, FINE PARTICLE DISPERSION LIQUID, AND IMAGE DISPLAY MEDIUM AND IMAGE DISPLAY APPARATUS - An object of the present invention is to provide white colored fine particles with high white reflectance and not easily precipitating in a dispersion medium compared to inorganic white pigments, a method of producing the fine particles, an image display medium and an image display apparatus having a high whiteness like a paper and an excellent display memorability using the fine particles. Therefore, the fine particles contain a polymer of a compound expressed by the following formula (1). | 2011-10-20 |
20110257355 | Process for producing acrylic acid - A process for producing acrylic acid of the present invention comprises the step of conducting gas-phase oxidative dehydrogenation of a composition containing propionaldehyde using a solid catalyst containing molybdenum and vanadium as essential components, thereby obtaining acrylic acid. The obtained acrylic acid is preferably purified by crystallization, and a monomeric component containing the purified acrylic acid is polymerized to thereby give a hydrophilic resin such as an absorbent resin and a water-soluble resin. | 2011-10-20 |
20110257356 | Synthesis of Poly-(P-Aryleneethynylene)s in Neat Water Under Aerobic Conditions - Provided are ethyne synthons comprising boron and related methods. Also provided are related water-soluble arylethynylene polymers capable of being synthesized in neat water under aerobic conditions. | 2011-10-20 |
20110257357 | APPARATUS FOR HEAT TREATMENT OF POLYESTER PARTICLE AND METHOD OF MULTISTAGE SOLID-PHASE POLYCONDENSATION OF POLYESTER PARTICLE - A multistage method for solid-phase polycondensation to prepare polyethylene terephthalate having an intrinsic viscosity of 0.70 dL/g, comprising continuous polycondensation is provided. | 2011-10-20 |
20110257358 | METHOD FOR PREPARING E-CAPROLACTAM FROM N-ACYL-6-AMINOCAPROIC ACID - The invention relates to a method for preparing ε-caprolactam comprising deacylating N-acyl-6-aminocaproic acid and forming ε-caprolactam. The deacylation may be carried out chemically or biocatalytically. The invention further relates to a host cell, comprising a recombinant vector comprising a nucleic acid sequence encoding an enzyme capable of catalysing the formation of 6-aminocaproic acid from N-acyl-6-aminocaproic acid. | 2011-10-20 |
20110257359 | LOW SHRINKAGE, DYEABLE MPD-I YARN - The invention relates a heat-treated poly(metaphenylene isophthalamide) polymer fiber having a crystalline structure as represented by a carbonyl stretch peak at a wavelength of 1,650 cm−1 in a Raman spectra response which before coloration with a dye, shrinks linearly 0.4 percent or less when exposed to 285 degrees Centigrade for 30 minutes; and which after contact with an aqueous red dye solution for 1 hour at 120 degrees Centigrade, has an “L” value coloration of at least 40 units lower than the “L” value of the fiber before coloration. | 2011-10-20 |
20110257360 | TETRACARBOXYLIC ACID OR POLYESTERIMIDE THEREOF AND PROCESS FOR PRODUCING THE SAME - The present invention provides a useful and novel alicyclic polyesterimide. | 2011-10-20 |
20110257361 | ALKYL BENZENE TETRACARBOXYLIC DIANHYDRIDE, MANUFACTURING METHOD THEREOF, POLYIMIDE, AND APPLICATION THEREOF - Disclosed is a 5-alkyl-1,2,3,4-benzene tetracarboxylic-1:2,3:4-dianhydride which is represented by the general formula (1) and has excellent solubility with respect to various organic solvents. Depending on the diamine that is used, a polyimide with excellent heat resistance or a polyimide with good workability at a low melting point can be provided, and in addition, a polyimide that exhibits excellent characteristics for electronic materials or the like can be provided. | 2011-10-20 |
20110257362 | POLYCARBONATE COPOLYMER AND METHOD OF PRODUCING THE SAME - The problem to be solved by the present invention is to provide a polycarbonate copolymer containing a plant-derived raw material, which is excellent in the mechanical strength and heat-resistant and assured of small refractive index, large Abbe number, small birefringence and excellent transparency. The present invention provides a polycarbonate copolymer containing a constitutional unit derived from a dihydroxy compound represented by the following formula (1) and a constitutional unit derived from an alicyclic dihydroxy compound, wherein the Abbe number is 50 or more and the 5% thermal reduction temperature is 340° C. or more; and a method of producing this polycarbonate copolymer by reacting a dihydroxy compound represented by the following formula (1) and an alicyclic hydroxy compound with a carbonic acid diester in the presence of a polymerization catalyst. | 2011-10-20 |
20110257363 | METHOD FOR PREPARING POLYARYLENE SULFIDE - The present invention relates to a method for preparing polyarylene sulfide, in which the polyarylene sulfide is prepared by a polymerization reaction of reactants including a diiodo aromatic compound and a sulfur compound, the method including: further adding 0.01 to 10.0 wt. % of diphenyl disulfide with respect to the weight of the polyarylene sulfide to the reactants to form the polyarylene sulfide having a melting point of 265 to 320° C. | 2011-10-20 |
20110257364 | PROCESS FOR PURIFYING GLYCOPEPTIDE PHOSPHONATE DERIVATIVES - Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a polystyrene-containing resin, eluting the resin with an aqueous solution, and isolating the purified glycopeptide derivative. | 2011-10-20 |
20110257365 | Cyclin Based Inhibitors of CDK2 and CDK4 - Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation. | 2011-10-20 |
20110257366 | Method for screening candidate compounds for antitumor drug - Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index. | 2011-10-20 |
20110257367 | ALLOGENEIC VACCINE AND METHODS TO SYNTHESIZE SAME - This invention provides a genetically manipulated cell useful for treating or preventing a malignant tumor in a patient which: (a) expresses at least one immunomolecule selected from the group consisting of cytokines, adhesion molecules, costimulatory factors, tumor associated antigens and tumor specific antigens; and (b) is allogeneic to the patient. This invention also provides a method of treating a malignant tumor in a subject which comprises administering to the subject a plurality of the genetically manipulated cell so as to inhibit proliferation of the malignant tumor. This invention further provides a method of preventing tumor formation in a subject comprising administering to the subject a plurality of the genetically manipulated cell so as to prevent tumor formation. Finally, this invention provides a method for making the genetically manipulated cell. | 2011-10-20 |
20110257368 | PURIFICATION OF RECOMBINANTLY PRODUCED INTERFERON - The present invention provides a method for separating desired interferon isoforms from undesired interferon isoforms that involves subjecting the isoforms to anion exchange column chromatography and a biphasic elution procedure. A strong elution solution is used in the first elution phase to facilitate elution of the desired isoform from the column and a weak elution solution is used in the second phase to suppress elution of the desired isoforms. | 2011-10-20 |
20110257369 | METHODS FOR REMOVING NICOTINE AND OTHER ALKALOIDS FROM SOLUBLE LEAF PROTEINS IN SOLANACEOUS AND OTHER PLANT SPECIES - Described herein is a process for removing nicotine and other alkaloids from plant leaf proteins. The plant leaf proteins may be derived from tobacco } | 2011-10-20 |
20110257370 | IMMUNOGLOBULIN PURIFICATION - The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5. In one embodiment the anion exchange chromatography material is a membrane anion exchange chromatography material. | 2011-10-20 |
20110257371 | Methods of Treating Chronic Pain - Methods of Treating Chronic Pain The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of chronic pain and/or symptoms of chronic pain, and to a method of treating and/or preventing chronic pain and/or symptoms of chronic pain using an anti-CGRP antibody. | 2011-10-20 |
20110257372 | IMMUNOGLOBULINS DEVOID OF LIGHT CHAINS - There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains. | 2011-10-20 |
20110257373 | LIGANDS THAT HAVE BINDING SPECIFICITY FOR DC-SIGN - The present invention disclosure provides an anti-dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN; CD209) immunoglobulin single variable domain. Polypeptides, ligands and compositions comprising such anti-DC-SIGN immunoglobulin single variable domains are also described along with nucleic acids encoding such immunoglobulins and vectors and host cells for expression. The invention disclosure further relates to uses, formulations, compositions and devices comprising such DC-SIGN-binding agents. | 2011-10-20 |
20110257374 | Novel Reagents for Directed Biomarker Signal Amplification - Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods. | 2011-10-20 |
20110257375 | INCREASING EFFICIENCY OF NUCLEIC ACID DELIVERY IN VIVO USING TARGETING CONJUGATES - Described herein is the use of antibody-based delivery agents to target and deliver nucleic acid agents into specific cell types. Herein, we describe methods used that improve the ability of conjugates that load over 3 siRNA per conjugate and target siRNA to cells expressing the appropriate cell surface antigens. We also contemplate the use of antibody, targeting peptides, small molecules, aptamers and all other factors known in the art that can specifically target tissues. In each case, these targeting moieties can be conjugated using chemical crosslinking agents to carriers enabling directed delivery of nucleic acids. | 2011-10-20 |
20110257376 | GLYCOPROTEOMIC PROBES FOR FLUORESCENT IMAGING OF FUCOSYLATED GLYCANS IN VIVO - Methods are provided for labeling cellular glycans bearing azide groups via fluorescent labeling comprising Cu(I)-catalyzed [3+2] cycloaddition of a probe comprising alkynyl group. Generation of fluorescent probes from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2] cycloaddition of the alkyne group of the probe to an azido-modified sugar are provided. Incorporation of azido-containing fucose analog into glycoconjugates via the fucose salvage pathway are disclosed. Fluorescent visualization of fucosylated cells by flow cytometry of cells treated with 6-azidofucose labeled with click-activated fluorogenic probe or biotinylated alkyne is disclosed. Visualization of intracellular location of fucosylated glycoconjugates by fluorescence microscopy are disclosed. | 2011-10-20 |
20110257377 | Covalently linked complexes of HIV TAT and ENV PROTEINS - Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies. | 2011-10-20 |
20110257378 | AQUEOUS TWO PHASE EXTRACTION AUGMENTED PRECIPITATION PROCESS FOR PURIFICATION OF THERAPEUTIC PROTEINS - The invention relates to an aqueous two phase extraction (ATPE) augmented precipitation process, which may be used to recover and also partially purify therapeutic proteins, including monoclonal antibodies from a crude multi-component mixture. The process involves the formation of a forward extraction PEG-Phosphate ATPE system in which the target product is preferentially partitioned to the polymer rich phase. A second ATPE back extraction system is then formed by introducing the polymer rich phase from the forward extraction to a new phosphate salt rich phase, causing the product to precipitate at the interface between the two phases. This precipitate is then recovered and resolubilised in a suitable buffer and may be passed on for further purification. | 2011-10-20 |
20110257379 | LEAD COMPOUND OF ANTI-HYPERTENSIVE DRUG AND METHOD FOR SCREENING THE SAME - A system for screening a small molecule library with 250,000 molecules to find out a compound of an anti-hypertensive drug aiming at human Angiotensin II type IA receptor is provided. The system includes a first database having a three-dimensional structure datum of a human Angiotensin II type IA receptor, a second database having molecular data of a plurality of small molecules, and a computer acquiring the three-dimensional structure datum and the molecular data from the first database and the second database respectively, wherein the computer has a molecular docking software for calculating a free energy of the human Angiotensin II type IA receptor bound to each of the plurality of small molecules, ranks the plurality of small molecules according to the respective free energy so as to select a top small molecule in the ranking as the compound of the drug. | 2011-10-20 |
20110257380 | GLYCOMIMETIC REPLACEMENTS FOR HEXOSES AND N-ACETYL HEXOSAMINES - Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative. | 2011-10-20 |
20110257381 | PHARMACEUTICAL COMPOSITION COMPRISING CHITO-OLIGOMERS - Compositions are provided comprising chito-oligomers obtainable from chitin, comprising oligomers of N-acetyl glucosamine (NAG) and glucosamine, wherein at least 50% of the oligomers have a chain length of about 2-50, and the degree of deacetylation of the oligomers is in the range of about 0-70%, preferably about 30-50%. The compositions are highly useful as pharmaceutical compositions for treatment of joint disorders such as rheumatoid arthritis and osteoarthritis. Also provided are methods for treatment of joint disorders and treatment against inflammatory activity. | 2011-10-20 |
20110257382 | Nucleic acid separation using immobilized metal affinity chromatography - An immobilized metal affinity chromatography (IMAC) method for separating and/or purifying compounds containing a non-shielded purine or pyrimidine moiety or group such as nucleic acid, presumably through interaction with the abundant aromatic nitrogen atoms in the purine or pyrimidine moiety. The method can also be used to purify compounds containing purine or pyrimidine moieties where the purine and pyrimidine moieties are shielded from interaction with the column matrix from compounds containing a non-shielded purine or pyrimidine moiety or group. Thus, double-stranded plasmid and genomic DNA, which has no low binding affinity can be easily separated from RNA and/or oligonucleotides which bind strongly to metal-charged chelating matrices. IMAC columns clarify plasmid DNA from bacterial alkaline lysates, purify a ribozyme, and remove primers and other contaminants from PCR reactions. The metal ion affinity of yeast RNA decreases in the order: copper (II), nickel (II), zinc (II), and cobalt (II). | 2011-10-20 |
20110257383 | RNA COMPLEXES, METHODS OF THEIR PRODUCTION - The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same. | 2011-10-20 |
20110257384 | METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA - The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded RNA (“dsRNA”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. The dsRNA has a first oligonucleotide sequence that is between 25 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of at least 19 nucleotides is sufficiently complementary to a nucleotide sequence of the RNA produced from the target gene to trigger the destruction of the target RNA by the RNAi machinery. | 2011-10-20 |
20110257385 | METHODS FOR FLIP-STRAND IMMOBILIZING AND SEQUENCING NUCLEIC ACIDS - Provided herein are compositions, materials, methods and kits for immobilizing a template polynucleotide in a first orientation, and immobilizing a complementary sequence of the template polynucleotide in an orientation that is flipped compared to the orientation of the template polynucleotide. Provided herein are adaptive oligonucleotides that can be used in various nucleic acid manipulations to generate immobilized complement polynucleotides that are flipped in orientation compared to the orientation of the immobilized template polynucleotides. | 2011-10-20 |
20110257386 | ISOLATION OF NUCLEIC ACID - A method for isolating a nucleic acid comprises: binding the nucleic acid to a solid phase at a first pH in the presence of a binding buffer, washing the bound nucleic acid with a wash solution, and eluting the nucleic acid from the solid phase at a second pH which is higher than the first pH. The wash solution comprises a buffer with a buffering range that encompasses a pH that is higher than the first pH, and the wash solution is at a pH that is within a buffering range of the binding buffer but lower than the buffering range of the buffer of the wash solution. Solutions, compositions, and kits for use in the methods are described. | 2011-10-20 |
20110257387 | PROCESS FOR PREPARING AN A2A-ADENOSINE RECEPTOR AGONIST AND ITS POLYMORPHS - Disclosed is a synthesis suitable for large scale manufacture of an A | 2011-10-20 |
20110257388 | CEFDINIR ACID DOUBLE SALT AND METHOD FOR PRODUCING THE SAME - A compound represented by Formula I, wherein M represents Na | 2011-10-20 |
20110257389 | CROSS-LINKED CYCLIC AMINE COMPOUNDS AND AGENTS FOR PEST CONTROL - Cyclic amine compounds represented by formula (1) | 2011-10-20 |
20110257390 | AMMOXIMATION PROCESS - A redox ammoximation process in which a ketone or aldehyde is reacted with ammonia and oxygen in the presence of a catalyst, wherein: the catalyst is an aluminophosphate based redox catalyst having the qualitative general formula (I) M | 2011-10-20 |
20110257391 | PROCESS FOR PRODUCTION OF QUINAZOLINE DERIVATIVE - A process for preparing a compound (III) is provided, in which the compound (III) is prepared from a methoxycarbonyl derivative through a methoxyamide derivative. These two reaction steps are continuously carried out and substantially the same as one step. The compound (III) is useful as a synthetic intermediate for preparing a dual tyrosine kinase inhibitor and can be conveniently prepared in high yield according to the present invention. | 2011-10-20 |
20110257392 | INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF - The present invention relates to a production method of an optically active morpholine compound represented by the formula 10, which includes the following steps: | 2011-10-20 |
20110257393 | Electronically Tuned Ligands For Asymmetric Hydrogenation - Disclosed is a new class of chiral bidentate ligands capable of performing asymmetric hydrogenation. Also disclosed are processes of performing asymmetric hydrogenation the chiral bidentate ligands. | 2011-10-20 |
20110257394 | CRYSTALS OF HYDROCHLORIDE OF PYRIDAZIN-3(2H)-ONE COMPOUND AND PROCESS FOR PRODUCTION OF SAME - Provided are novel crystals of 4-bromo-6-(3-(4-chloro-phenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one monohydrochloride, and a process for production of same. A-form crystals of 4-bromo-6-(3-(4-chlorophenyl)propoxy)-5-(pyridin-3-ylmethylamino)pyridazin-3(2H)-one monohydro-chloride represented by formula (1), which exhibit a powder X-ray diffraction pattern with characteristic peaks at diffraction angles (2θ) of 8.24, 11.24, 11.76, 16.48, 17.16, 17.80, 18.24, 19.80, 21.64, 22.56, 22.96, 23.68, 24.52, 25.92, 26.32, 27.12, 27.40, 28.00, 28.64, 29.28, 31.84 and 34.80°. | 2011-10-20 |
20110257395 | Chemical Process - The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline. | 2011-10-20 |
20110257396 | PROCESS FOR THE MANUFACTURE OF CIS(-)-LAMIVUDINE - An improved process for the manufacture of Lamivudine. The process involves: | 2011-10-20 |
20110257397 | Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof - There is provided a method for resolving a compound of formula III, in the cis configuration: | 2011-10-20 |
20110257398 | Compositions and Methods Including Cell Death Inducers and Procaspase Activation - Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3. | 2011-10-20 |
20110257399 | Fluorescent calcium indicators that are ratiometric and emit in the red spectrum - A new generation of fluorescent ion indicators for measuring cytosolic concentrations of calcium. These new indicators emit in the red portion of the visible spectrum and are ratiometric. The ratiometry consists of shifting in the emission upon binding calcium when exciting with an argon laser at 488 nm. These indicators also show marked increases in red fluorescence when excited with visible light at longer wavelengths. Like all calcium indicators, they comprise the usual chelating portion based on BAPTA (Bis Amino Phenyl Tetraacetic Acid) and a fluorophore portion, either a seminaphthofluorescein/seminaphthorhodamine or dinaphthofluorescein, which enable ratiometry. Unlike other naphthofluoresceins, the pKa has been adjusted on the naphtho moiety to make it suitable for biological calcium measurements. The invention relates to the structures of the indicators and to the method of synthesizing these indicators. | 2011-10-20 |
20110257400 | MATERIALS AND METHODS FOR THE PREPARATION OF ANISOTROPICALLY-ORDERED SOLIDS - The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties. | 2011-10-20 |
20110257401 | PROCESS FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID - It has been demanded to provide a process for industrially producing an intermediate for a compound that exhibits an inhibitory effect on activated blood coagulation factor X and is useful as a preventive and/or therapeutic agent for thrombotic diseases. The present invention provides a process for producing the (R)-α-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid, comprising reacting 3-cyclohexene-1-carboxylic acid and (R)-α-phenylethylamine using a mixed solvent of water and acetone or a mixed solvent of water and ethyl acetate as a solvent. | 2011-10-20 |
20110257402 | PYRRAZOLOPYRIDINE COMPOUNDS AS DUAL NK1/NK3 RECEPTOR ANTAGONISTS - The present invention relates to a compound of formula I | 2011-10-20 |
20110257403 | Processes and Intermediates for Preparing a Macrocyclic Protease Inhibitor of HCV - The present invention relates to the cinchonidine salt | 2011-10-20 |
20110257404 | METHOD OF PRODUCING AROMATIC AMINO COMPOUNDS - [Problem] To provide a method of producing an aromatic amino compound by using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively. | 2011-10-20 |
20110257405 | PROCESS FOR PRODUCING CRYSTAL - The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H | 2011-10-20 |
20110257406 | FUNCTIONALIZED SUBSTRATE AND USES THEREOF - The present invention is directed towards proposing ligands of formula: | 2011-10-20 |
20110257407 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 2011-10-20 |
20110257408 | ENANTIOSELECTIVE PROCESS FOR CYCLOALKENYL ?-SUBSTITUTED ALANINES - A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: | 2011-10-20 |
20110257409 | Ionic Liquid Epoxy Resin Monomers - Ionic liquid epoxide monomers capable of reacting with cross-linking agents to form polymers with high tensile and adhesive strengths. Ionic liquid epoxide monomers comprising at least one bis(glycidyl) N-substituted nitrogen heterocyclic cation are made from nitrogen heterocycles corresponding to the bis(glycidyl) N-substituted nitrogen heterocyclic cations by a method involving a non-nucleophilic anion, an alkali metal cation, epichlorohydrin, and a strong base. | 2011-10-20 |
20110257410 | METHODS FOR THE PREPARATION OF FUNGICIDES - The present invention relates to methods of preparing compounds of formula (I) comprising the step of reacting the corresponding amide with the corresponding substituted aryl in the presence of a catalyst, which catalyst comprises copper and a ligand, Y is CHCHR | 2011-10-20 |
20110257411 | Process for Preparing Dithiine-tetracarboxy-diimides - The present invention relates to a new process for preparing dithiine-tetracarboxy-diimides. | 2011-10-20 |
20110257412 | ALUMINIUM COMPLEXES AND USE THEREOF AS A CATALYST IN INTRAMOLECULAR RING CLOSURE REACTIONS - To provide a process for increasing the proportion of an optical isomer of not only a compound having a closed ring but also a compound not having a closed ring when an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule is subjected to a ring closing reaction. A process for increasing the proportion of an optical isomer characterized by subjecting an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule to a ring closing reaction in the presence of a predetermined aluminum complex represented by the general formula: [Al | 2011-10-20 |
20110257413 | CATALYST AND METHOD FOR PRODUCING MALEIC ANHYDRIDE - The invention relates to a catalyst molded body for preparing maleic anhydride by gas-phase oxidation of a hydrocarbon having at least four carbon atoms using a catalytically active composition contains vanadium, phosphorus and oxygen, where the shaped catalyst body has an essentially cylindrical body having a longitudinal axis, wherein the cylindrical body has at least two parallel internal holes which are essentially parallel to the cylinder axis of the body and go right through the body. The catalyst molded body has a large outer surface area, a lower pressure loss and sufficient mechanical stability. | 2011-10-20 |
20110257414 | CATALYST MOLDED BODIES AND METHOD FOR PRODUCING MALEIC ACID ANHYDRIDE - The catalytically active mass of a catalyst molded body comprises a multi-element oxide containing vanadium and phosphorus. The specific pore volume PV (in ml/g) of the catalyst molded body, the bulk density p of the catalyst molded body (in kg/l), the geometric surface area A | 2011-10-20 |
20110257415 | EPOXIDATION CATALYSTS - The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods. | 2011-10-20 |
20110257416 | SYNTHESIS OF LIQUID FUELS AND CHEMICALS FROM OXYGENATED HYDROCARBONS - Processes and reactor systems are provided for the conversion of oxygenated hydrocarbons to hydrocarbons, ketones, cyclic ethers and alcohols useful as liquid fuels, such as gasoline, jet fuel or diesel fuel, and industrial chemicals. The process involves the conversion of oxygenated hydrocarbons, such as alcohols, ketones, aldehydes, furans, carboxylic acids, diols, triols, and/or other polyols, to C | 2011-10-20 |
20110257417 | HIV-1 INHIBITING PHARMACEUTICAL COMPOSITION CONTAINING AN ECKLONIA CAVA-DERIVED PHLOROGLUCINOL POLYMER COMPOUND - The present invention relates to a HIV-1 inhibiting pharmaceutical composition containing, as an active ingredient, 6,6′-bieckol which is a phloroglucinol polymer compound separated from Ecklonia cava. The Ecklonia cava-derived 6,6′-bieckol according to the present invention inhibits HIV-1 induced cell fusion, the cell lysis effect, and the cytopathogenic effect including virus p24 antibody production, exhibits RT enzyme inhibition activity and HIV-1 infection inhibition activity, and shows no cytotoxicity at the concentration that almost perfectly inhibits HIC-1 replication. | 2011-10-20 |
20110257418 | Process for Preparing Zanamivir and Intermediates for Use in the Process - The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminium hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir. | 2011-10-20 |
20110257419 | Hydroxymethylfurfural Reduction Methods and Methods of Producing Furandimethanol - A method of reducing hydroxymethylfurfural (HMF) where a starting material containing HMF in a solvent comprising water is provided. H | 2011-10-20 |
20110257420 | CATALYST WITH BIMODAL PORE SIZE DISTRIBUTION AND THE USE THEREOF - The invention pertains to a catalyst useful for the epoxidation of an olefin. More particularly, the invention pertains to an improved catalyst useful for the epoxidation of ethylene to ethylene oxide. The catalyst has improved selectivity in the epoxidation process. The catalyst comprises a solid support having a surface, which has a first mode of pores which have a diameter ranging from about 0.01 μm to about 5 μm and having a differential pore volume peak in the range of from about 0.01 μm to about 5 μm. The surface then has a second mode of pores, different from the first mode of pores, which second mode of pores have a diameter ranging from about 1 μm to about 20 μm and have a differential pore volume peak in the range of from about 1 μm to about 20 μm. On the bimodal pore surface is a catalytically effective amount of silver or a silver-containing compound, a promoting amount of rhenium or a rhenium-containing compound, and a promoting amount of one or more alkali metals or alkali-metal-containing compounds. | 2011-10-20 |
20110257421 | 7-N-Substituted Phenyl Tetracycline Compounds - 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described. | 2011-10-20 |
20110257422 | Process For Producing Organohalohydrosilanes - The invention pertains to a method of producing organohalohydrosilanes by treating a silicon metal with a halogen-containing compound, wherein the halogen-containing compound has a formula selected from R | 2011-10-20 |
20110257423 | PROCESS FOR PRODUCING FLUOROELASTOMERS - An emulsion polymerization process for the production of fluoroelastomers is disclosed wherein at least one fluorosurfactant is employed as dispersant, said fluorosurfactant being a fluoroalkylphosphoric acid ester of the formula X—Rf—(CH | 2011-10-20 |
20110257424 | Process for Producing C1-C4 Alkyl Nitrite - A process of producing C | 2011-10-20 |
20110257425 | Process for Producing Cl-C4 Alkyl Nitrite - The present invention relates to a process for producing C | 2011-10-20 |
20110257426 | PROCESS FOR PREPARING CARBOXYLIC ESTERS BY REACTIVE DISTILLATION - In a process for preparing carboxylic esters by transesterification, a first feed stream comprising a first carboxylic ester, e.g. methyl formate, is introduced laterally into a reaction column at least one first feed point located between top and bottom of the reaction column and a second feed stream comprising a first alcohol, e.g. ethanol, is introduced laterally into the reaction column at a second feed point located above the first feed point and are reacted in a reaction zone of the reaction column to form a second carboxylic ester and a second alcohol. The first alcohol has a higher molecular weight than the second alcohol. A product fraction comprising the second carboxylic ester and unreacted first carboxylic ester is taken off at an offtake point located above the second feed point. At the bottom of the reaction column, a bottom fraction comprising the second alcohol and unreacted first alcohol is taken off. The product fraction is separated by distillation at a pressure which is different from the pressure in the reaction column into second carboxylic ester and a fraction comprising unreacted first carboxylic ester and the fraction comprising unreacted first carboxylic ester is at least partly recirculated to the reaction zone. | 2011-10-20 |
20110257427 | PURIFICATION OF CARBOXYLIC ESTERS BY EXTRACTIVE DISTILLATION - In a process for purifying carboxylic esters such as ethyl formate, a carboxylic ester to be purified is distilled in the presence of an extractant, preferably by (a) allowing vapor of the carboxylic ester to be purified to ascend in a distillation column; (b) conveying the extractant in countercurrent to the vapor in an extractive distillation column; (c) taking off pure carboxylic ester above the extractive distillation zone. The extractant is, for example, selected from among diols, polyols, open-chain or cyclic amides. | 2011-10-20 |
20110257428 | PROCESS FOR PREPARING ISOCYANATES - The invention relates to a process for preparing isocyanates by reacting the corresponding amines with phosgene in the gas phase, optionally in the presence of an inert medium, in which the amine and the phosgene are first mixed and converted to the isocyanate in a reactor, and in which a reaction gas ( | 2011-10-20 |
20110257429 | METHOD FOR PRODUCING A FREE ACID FROM THE SALT THEREOF - The invention relates to an improved method for releasing an organic acid, preferably a carbon, sulfone or phosphone acid, particularly an alpha or beta hydroxycarbon acid, from the ammonia salt thereof by releasing and removing ammoniac and simultaneous extraction of the released acid, having an amine as a suitable extraction means from the aqueous phase. This method corresponds to a reactive extraction. The reactive extraction of an organic acid from the aqueous ammonia salt solution thereof can be significantly improved by the use of a strip medium or carrier gas, such as nitrogen, air, water vapor or inert gases such as argon. The released ammoniac is removed from the aqueous solution by the continuous gas flow and can be resupplied into a production process. The free acid can be obtained by a method such as distillation, rectification, crystallization, reextraction, chromatography, adsorption or by a membrane method from the extraction means. | 2011-10-20 |
20110257430 | NOVEL COCRYSTALLIZATION - The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases. | 2011-10-20 |
20110257431 | PROCESS FOR PRODUCING SIDE PRODUCT-FREE AMINOCARBOXYLATES - The present invention relates to a process for preparing aminocarboxylates, proceeding from amines, by employing a reaction sequence composed of ethoxylation to amino alcohols and subsequent oxidative dehydrogenation to the corresponding aminocarboxylates, especially the alkali metal or alkaline earth metal salts of the complexing agents MGDA (methylglycinediacetic acid), EDTA (ethylenediaminetetra-acetic acid) and GLDA (glutamic acid diacetic acid) or the free acids thereof. | 2011-10-20 |
20110257432 | Metformin-Cysteine Prodrug - A metformin-cysteine prodrug. It is believed that the prodrug of the present invention will transport in the LAT1 and LAT2 transporter system. Because the LAT1 and LAT2 transporters are important and effective transporters of amino acids in both the small intestine and colon, it is believed that the LAT-transportable prodrugs of the present invention will be effectively absorbed both in small intestine and in the colon. The increased absorption window provided by the present invention should result in highly sustained plasma concentrations of metformin, thereby increasing the effectiveness of the medication and allowing for a single daily dose. | 2011-10-20 |
20110257433 | LIQUIDS - The present invention relates to an ionic liquid comprising an anion and a cation, wherein the cation is a primary, secondary or tertiary ammonium ion containing a protonated nitrogen atom. | 2011-10-20 |
20110257434 | PERTURBED MEMBRANE-BINDING COMPOUNDS AND METHODS OF USING THE SAME - The invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, i.e., cells undergoing cell death, apoptotic cells or activated platelets. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes. | 2011-10-20 |
20110257435 | FUNCTIONALIZED CATIONIC POLYAMINES AND THEIR USE TO REDUCE THE NDMA FORMATION DURING THE TREATMENT OF AQUEOUS SYSTEMS, AND APPLICATIONS IN THE WATER TREATMENT INDUSTRY, INCLUDING WASTEWATER AND DRINKING WATER TREATMENT PROCESSES - New water treatment chemicals and corresponding water treatment or more generally aqueous systems treatment processes are provided, which greatly attenuate the NDMA problem, that is, decrease the formation of NDMA during the water or aqueous system treatment namely in the presence of a disinfectant, and decrease too the level of NDMA in the so treated water of the aqueous system, and in the end products such as drinking water. | 2011-10-20 |
20110257436 | PROCESS FOR THE MANUFACTURE OF EASILY DISPERSIBLE, SOLID N'-HYDROXY-N-CYCLOHEXYL-DIAZENIUM OXIDE SALTS - Process for the manufacture of solid M | 2011-10-20 |
20110257437 | PROCESS FOR PREPARING PURE TRIETHANOLAMINE (TEOA) - A process for preparing pure triethanolamine (TEOA) by continuously distillatively separating an ethanolamine mixture comprising TEOA and diethanolamine (DEOA), by distilling off DEOA in a distillation column (DEOA column) and supplying the resulting bottom stream comprising TEOA to a downstream column (TEOA column) in which the pure TEOA is withdrawn as a side draw stream, wherein the residence time of the ethanolamine mixture in the bottom of the DEOA column is <20 minutes. | 2011-10-20 |
20110257438 | SULFONE COMPOUND - It is an object of the present invention to provide an aprotic polar solvent mainly useful as a solvent for an electrochemical device, and having a comparatively low melting point and excellent thermal stability. | 2011-10-20 |
20110257439 | Process for the Preparation of 4-(4-hydroxyphenyl)butan-2-one Using Solid Acid Clay Catalyst - Solid acid catalyst such as acid activated-Montmorillonite clay composite has been developed by modifying the Na-Montmorillonite clay with acid (HCl) treatment for different periods such as 5 minutes to about 4 hours and activating at about 12O° C. for about 2 hours. Friedel Crafts alkylation reaction between phenol and 4-hydroxybutan-2-one in presence of the acid activated Montmorillonite clay catalysts exhibiting layered clay structures (basal spacing d | 2011-10-20 |
20110257440 | METHOD OF PRODUCING FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER - The present invention provides a preparation method of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether by reacting CH | 2011-10-20 |