38th week of 2008 patent applcation highlights part 53 |
Patent application number | Title | Published |
20080227975 | METHOD OF PRODUCING FR901228 - Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion. | 2008-09-18 |
20080227976 | PROCESS FOR SYNTHESIZING ASPARTIC AND GLUTAMIC ACID DERIVATIVES ESPECIALLY USEFUL AS INTERMEDIATES IN THE MANUFACTURE OF A CASPASE INHIBITOR - The invention relates to novel diazoketone derivatives. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors. | 2008-09-18 |
20080227977 | Thiol compound derivative, curable composition containing the derivative, and molded product thereof - The present invention relates to a thiol compound derivative represented by the following formula (1), a curable composition containing the derivative, and a molded product made of the composition. More particularly, the invention relates to a thiol compound derivative which is added to a polymer having reactivity to a thiol derivative substituent to provide a curable composition, a curable composition containing the derivative and a crosslinkable halogen-containing crosslinking polymer, and a crosslinked molded product of the composition. | 2008-09-18 |
20080227978 | Method for the Preparation of Enantiomerically Enriched Secondary Alcohols by the Addition of Organoaluminium Reagents to Carbonyl Compounds - A process for converting a carbonyl group within a substrate to a chiral alcohol moiety comprising reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; novel chiral ligands and organoluminium reagents, a chiral ligand or organoaluminium reagent for use in the process. | 2008-09-18 |
20080227979 | Pyrido[3,2-h]quinazolines and/or 5,6-dihydro derivatives thereof, a method for the production thereof and doped organic semiconductor material containing these - The present invention relates to pyrido[3,2-h]quinazolines and/or 5,6-dihydro derivatives thereof, methods for their production and doped organic semiconductor material which use such quinazolines. | 2008-09-18 |
20080227980 | Preparation of a 7H-Pyrrolo [2,3-D] Pyrimidine Derivative - The present invention provides highly efficient methods for the preparation of {6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-((R)-1-phenyl-ethyl)-amine (I). | 2008-09-18 |
20080227981 | CHARGE TRANSPORT COMPOSITIONS AND ELECTRONIC DEVICES MADE WITH SUCH COMPOSITIONS - The present invention relates to charge transport compositions. The invention further relates to electronic devices in which there is at least one active layer comprising such charge transport compositions. | 2008-09-18 |
20080227982 | SOLVENT FREE AMORPHOUS RAPAMYCIN - An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeutic agents. | 2008-09-18 |
20080227983 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION - The present invention relates to substantially pure piperidine derivative compounds of the formulae: | 2008-09-18 |
20080227984 | Selective Oxidation of Organic Compounds - This invention relates to the selective oxidation of organic compounds. According to the invention organic compounds are selectively oxidized using a peracid or a source of peracid, a transition metal based heterogeneous catalysts and a borate or boric acid in the presence of water. Using the process of the present invention, both excellent conversion and product selectivity maybe obtained. | 2008-09-18 |
20080227985 | SYNTHESIS OF CHIRALLY PURIFIED SUBSTITUTED BENZOTHIAZOLES - Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein. | 2008-09-18 |
20080227986 | Preparation of N-Substituted Isothiazolinone Derivatives - Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II) or N,N′-bis-substituted 3,3′-dithiodipropionamides of formula (III) with sulfuryl chloride in the absence of solvents. Also provided is a process for the preparation of a compound having the general formula (III), comprising reacting a methyl ester of formula (IV) with an amine of formula (V) in a solvent of methanol. As no addition solvent is used in the process of the invention, the cost of manufacturing and pollution to the environment can be reduced. | 2008-09-18 |
20080227987 | Process for the Preparation of Onium Alkylsulfites - The invention relates to a process for the preparation of onium alkylsulfites by reaction of an onium halide or carboxylate with a symmetrically substituted dialkyl sulfite or with an asymmetrically substituted dialkyl sulfite at temperatures of 0 to 70° C. | 2008-09-18 |
20080227988 | Crystallisation and Purification of Glycopyrronium Bromide - A method for the production of crystalline glycopyrronium bromide, comprises the reaction of glycopyrronium base with methyl bromide in a solvent, in which the solvent is selected such that the diastereoisomeric ratio of the product favours the R, S and S, R diastereoisomers over the R, R, and S, S diastereoisomers, and separating the desired diastereoisomers by one or more controlled crystallisation steps. This method gives a product having a particle size of narrow distribution. | 2008-09-18 |
20080227989 | Methyl 2,4,9-trithiaadamantane-7-carboxylate - Methyl 2,4,9-trithiaadamantane-7-carboxylate and a method for its manufacture is disclosed. The method reacts oxidized methyl triallyl acetate with a Lewis acid and a sulphuring agent. | 2008-09-18 |
20080227990 | Process For Purifying Thioctic Acid in Water - Process for purifying thioctic acid in water comprising the following steps: a) dissolving the thioctic acid in an aqueous alkaline solution or alternatively dissolving a thioctic acid salt, if necessary adjusting the pH to alkaline values, b) acidifying the solution from step (a) with an acid chosen from the class consisting of sulfuric acid, phosphoric acid, methanesulfonic acid to a pH between 5.4 and 5.8. c) isolating the thioctic acid precipitated in step (b) by conventional methods. | 2008-09-18 |
20080227991 | Sodium salt of disaccharide compound, production method and use of same - The present invention relates to a sodium salt represented by average formula (I): | 2008-09-18 |
20080227992 | Catalyst and Methods for Producing Maleic Anhydride - Catalysts comprising a catalytically active composition, the catalytically active composition comprising vanadium, phosphorus, iron and oxygen, wherein the catalytically active composition has an iron:vanadium atomic ratio of 0.005 to <0.05, and wherein iron in the catalytically active composition is derived from an iron starting material comprising Fe(III) phosphate; and processes for making such catalysts as well as uses therefor to prepare maleic anhydride are described. | 2008-09-18 |
20080227993 | Synthesizing and compounding molecules from and with plant oils to improve low temperature behavior of plant oils as fuels, oils and lubricants - The present invention is a method for making a class of molecules synthesized from unsaturated plant oils, and the synthesized class of molecules, such that when compounded with saturated plant oils they improve the physical properties such as low temperature behavior, measured as cold filter plug point and cloud point for biodiesel fuels and pour point for oils and lubricants, as well as other physical properties including viscosity and viscosity index, so that the physical properties of the combined materials approach the physical properties of unsaturated plant oils and find use as base material feed stocks for “Green” fuel, oil, and lubricant products. | 2008-09-18 |
20080227994 | Process For the Production of Carboxylic Acid Esters - The invention relates to a process for the production of carboxylic acid esters by esterification of carboxylic acids and/or transesterification of carboxylic acid esters with alcohols in the presence of a liquid metal catalyst, characterized in that the liquid metal catalyst is the alkaline earth metal salt of a carboxylic acid. | 2008-09-18 |
20080227995 | Process of Sulfonating 4-Aminobenzonitriles - A process of producing a compound of the following formula (3): | 2008-09-18 |
20080227996 | Sulfonated Amorphous Carbon, Process for Producing the Same and Use Thereof - An amorphous carbon having sulfonate group introduced therein is provided which is characterized in that chemical shifts of a condensed aromatic carbon 6-membered ring and a condensed aromatic carbon 6-membered ring having sulfonate group bonded thereto are detected in a | 2008-09-18 |
20080227997 | Preparation of phosphorus-containing propoxylation products by using aluminium trichloride - The invention describes a process for preparing propoxylated, phosphorus-containing compounds using aluminium chloride catalyst. | 2008-09-18 |
20080227998 | Method For Producing 3-Pentenenitrile - A process is described for preparing 3-pentenenitrile, characterized by the following process steps:
| 2008-09-18 |
20080227999 | Heterogeneous Supported Catalytic Carbamate Process - A process for the preparation of aromatic carbamates comprising contacting one or more organic carbonates with an aromatic amine or urea in the presence of a catalyst and recovering the resulting aromatic carbamate product, characterized in that the catalyst is a heterogeneous catalyst comprising a Group 12-15 metal compound supported on a substrate. | 2008-09-18 |
20080228000 | Cinchona Alkaloid-Catalyzed Asymmetric Mannich Reactions - The instability of carbamate-protected alkyl imines has greatly hampered the development of catalytic asymmetric Mannich reactions suitable for the synthesis of optically active carbamate-protected chiral alkyl amines. A highly enantioselective Mannich reaction with in situ generation of carbamate-protected imines from stable α-amido sulfones catalyzed by an organic catalyst has been developed. This reaction provides a concise and highly enantioselective route converting aromatic and aliphatic aldehydes into optically active aryl and alkyl β-amino acids. | 2008-09-18 |
20080228001 | Process for Producing (Meth)Acrylic Acid or (Meth)Acrolein - An object of the present invention is to provide a method for producing (meth)acrylic acid or (meth)acrolein by conducting a gas phase catalytic oxidation reaction with an oxygen-containing gas using as a raw material at least one substance to be oxidized selected from propylene, propane, isobutylene and (meth)acrolein using a multi-tubular reactor, which enables a high yield and stable production even when operating constantly with supplying the raw material in the maximum supply amount acceptable by the reactor or an amount close thereto. | 2008-09-18 |
20080228002 | Metal Surfaces to Inhibit Ethylenically Unsaturated Monomer Polymerization - Materials for making apparatus and a method of inhibiting polymerization during manufacture, purification, handling and storage of subject ethylenically unsaturated monomers are disclosed. In particular, copper or metals containing copper, in the presence of oxygen, have inhibit undesired polymerization resulting in polymer fouling in apparatus used during the manufacture, purification, handling and storage of the monomers, such as acrylic acid, methacrylic acid, acrylic acid esters and methacrylic acid esters. The copper or copper alloys as described herein, in the presence of an oxygen-containing gas, exhibit self-inhibiting surface characteristics when used to make at least a portion of the apparatus to inhibit polymerization of the monomers in contact with the portion of the apparatus including such copper-containing metal. | 2008-09-18 |
20080228003 | METHOD FOR PRODUCING (METH) ACRYLIC ACID DERIVITIVE - The present invention provides a method for efficiently using an aqueous solution of (meth)acrylic acid at a low concentration formed in a production/storage step of (meth)acrylic acid. | 2008-09-18 |
20080228004 | Ligand Protection for Mercaptoacetyl Triglycine - The present invention relates to a method for preparing mercaptoacetyl triglycine labeled with a radionuclide, comprising the steps of adding a radionuclide to a solution that comprises a mercaptoacetyl triglycine dimer of formula VI, a reducing agent and optionally a transfer ligand and heating the thus obtained solution. The invention relates to the mercaptoacetyl triglycine dimer and its use in the method, to a kit for performing the method and to the formulation obtained from the method. | 2008-09-18 |
20080228005 | Polymorphs of suberoylanilide hydroxamic acid - The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. The present invention also provides a novel Form I polymorph of SAHA, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure. | 2008-09-18 |
20080228006 | Method For the Reduction of Chlorine-Containing Components in Organic Isocyanates - The invention relates to a method for largely eliminating chlorine compounds from organic isocyanates or isocyanate mixtures by contacting said isocyanates or isocyanate mixtures with a water-containing inert gas flow or an organic material having a cation-exchanging effect. The inventive method allows the isocyanates to be gently freed from chorine-containing compounds and is particularly suitable for temperature-sensitive isocyanates. | 2008-09-18 |
20080228007 | METHOD FOR PRODUCING CYCLOALKANOL AND/OR CYCLOALKANONE - An object of the present invention is to provide a method capable of producing cycloalkanol and/or cycloalkanone with a favorable selectivity by oxidizing cycloalkane with a favorable conversion. | 2008-09-18 |
20080228008 | Substituted Cyclohexanones - The present invention relates to a cyclohexanone derivative of formula | 2008-09-18 |
20080228009 | Process for Preparing 1,1,4,4-Tetraalkoxybut-2-Ene Derivatives - Process for preparing 1,1,4,4-tetraalkoxybut-2-ene derivatives of the general formula (I), | 2008-09-18 |
20080228010 | Alkoxylation process for preparing ether alkanol derivatives of phenolic compounds - This invention provides an alkoxylation process for creating alkoxylating chain extension of phenolic compounds by reacting phenolic compounds with alkylene glycol and urea in the presence of suitable catalysts to obtain alkoxylated compounds, which may be used as polymer intermediates, especially for use as raw materials to synthesize polyurethane (PU) or polyester. | 2008-09-18 |
20080228011 | Methods for Producing Triol Ethers by Reactive Distillation - This invention relates to methods for preparing alkyl ethers from glycerin by reactive distillation. For example, the present invention provides a method for the preparation of mono-, di- and tri-ethers of glycerin, either in the presence or absence of fatty acids, contaminants by reactive distillation using solid catalysts. Specific desirable final products according to the reactive distillation method provided herein include glycerin ethers and fatty acid esters of C | 2008-09-18 |
20080228012 | Method for producing alcohols - A method for producing alcohols which comprises reducing esters or lactones with hydrogen gas in the presence of a catalyst comprising (i) a ruthenium compound, (ii) a monodentate monophosphine or a bidentate bisphosphine, and (iii) an amine. Examples of the catalyst include a ruthenium (Ru) complex represented by the formula:RuX | 2008-09-18 |
20080228013 | Process for purifying menthol - Crude menthol is dissolved in nitrile series solvent and then menthol is precipitated by cooling the solution to thereby obtain optically and chemically substantially pure menthol, the enantiomeric excess thereof being more than about 99% e.e. and the chemical purity being more than about 99%. Preferred examples of the nitrile series solvent include acetonitrile and propionitrile. The dissolution of crude menthol is carried out at a temperature below 42° C., which is the melting point of menthol. The cooling temperature in crystallization is preferably at a room temperature or a little lower temperature than the room temperature. After crystallization of menthol, additional purification process such as a distillation may be conducted, if necessary. | 2008-09-18 |
20080228014 | Hydrogenolysis of Glycerol and Products Produced Therefrom - Processes for the hydrogenolysis of glycerol, as well as products produced therefrom are disclosed. | 2008-09-18 |
20080228015 | PREPARATION AND PROVISION OF HIGH ASSAY DECABROMODIPHENYLETHANE - High assay reaction-derived decabromodiphenylethane product is produced and provided. The process comprises feeding diphenylethane, a partially brominated diphenylethane, or both subsurface into the liquid phase of a reaction mixture formed from components comprising excess liquid bromine and aluminum-based Lewis acid bromination catalyst. The temperature of the reaction mixture, the catalyst concentration in the excess bromine in the reaction mixture, and the feed time are coordinated in the processes to produce high assay reaction-derived decabromodiphenylethane product. Ways of effecting such coordination are described. | 2008-09-18 |
20080228016 | Method for Chlorinating Alcohols - A process for preparing organic chlorides in which the chlorine atom is bonded to a CH | 2008-09-18 |
20080228017 | Metathesis Process For Preparing An Alpha, Omega-Functionalized Olefin - A cross-metathesis process for preparing an α,ω-functionalized olefin, such as methyl 9-decenoate, and an α-olefin having three or more carbon atoms, such as 1-decene. The process involves contacting in a first reaction zone an α-functionalized internal olefin, such as methyl oleate, and an α-olefinic monomer having three or more carbon atoms, such as 1-decene, with a first metathesis catalyst to prepare an effluent stream containing the α,ω-functionalized olefin, such as methyl 9-decenoate, an unfunctionalized internal olefin, such as 9-octadecene, unconverted reactant olefins, and optionally, an α,ω-difunctionalized internal olefinic dimer, such as dimethyl 9-octadecen-1,18-dioate; separating said effluent streams; then contacting in a second reaction zone the unfunctionalized internal olefin with ethylene in the presence of a second metathesis catalyst to obtain a second product effluent containing the α-olefinic monomer having three or more carbon atoms; and cycling a portion of the α-olefinic monomer stream(s) to the first zone. | 2008-09-18 |
20080228018 | Transalkylation of Heavy Alkylate Using a Layered Catalyst - A layered catalyst is disclosed for use in transalkylation of polyalkylated benzenes. The catalyst comprises an inner core material with a molecular sieve bonded over the core. The process minimizes the cracking of the alkyl groups during the transalkylation reaction. | 2008-09-18 |
20080228019 | Method for Obtaining Raw -1,3-Butadiene - The invention relates to a method for obtaining raw-1,3-butadiene by extractive distillation with a selective solvent from a C | 2008-09-18 |
20080228020 | Method for Converting Ethylene Into Propylene - The invention relates to a method for converting ethylene into propylene consisting in reacting said ethylene with a supported metal compound comprising an aluminium oxide based support to which a tungsten hydride is grafted. Said reaction is carried out at a temperature ranging from 20 to 600° C., preferably between 50 and 350° C., at an absolute pressure ranging from 0.01 to 8 MPa, preferably between 0.01 and 1 MPa. A catalyst is regeneratable by introducing hydrogen at a temperature of 50-300° C. | 2008-09-18 |
20080228021 | Process For Converting Difficultly Convertible Oxygenates to Gasoline - Process for converting oxygenate compounds to hydrocarbons comprising the steps: (a) introducing a feed stream of synthesis gas to a synthesis section for the production of easily convertible oxygenates, (b) passing the effluent stream from said synthesis section containing easily convertible oxygenates to a gasoline synthesis section, (c) passing the effluent of said gasoline synthesis section to a separator and withdrawing from said separator hydrocarbons boiling in the gasoline boiling range, (d) admixing a recycle stream from the separator containing unconverted synthesis gas volatile hydrocarbons with the feed stream of synthesis gas of step (a), (e) introducing a feed containing difficulty convertible oxygenates to the synthesis section of step (a). | 2008-09-18 |
20080228022 | Vacuumable Gel for Decontaminating Surfaces and Use Thereof - The present invention relates to a vacuumable gel that can be used for decontaminating surfaces, and also to the use of this gel. The decontamination may be, for example, a radioactive decontamination. The gel of the present invention is composed of a colloidal solution. It comprises from 5 to 25 wt % of an inorganic viscosity modifier relative to the total weight of the gel; from 0.01 to 0.2 wt % of a surfactant relative to the total weight of the gel, and, particularly preferably, a surfactant in an amount strictly below 0.1 wt % relative to the total weight of the gel; from 0.5 to 7 mol, per litre of gel, of an inorganic acid or base; and optionally from 0.05 to 1 mol, per litre of gel, of an oxidizer having a standard redox potential E | 2008-09-18 |
20080228023 | Soft body catheter with low friction lumen - The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein. | 2008-09-18 |
20080228024 | Soft body catheter with low friction lumen - The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein. | 2008-09-18 |
20080228025 | Radiation catheter with multilayered balloon - The disclosure is directed to catheter devices and methods for controlled application of irradiation to tissue adjacent a body site, such as cavity after removal of tissue, e.g. cancer. The catheter device includes an inflatable balloon having at least two layers. The inflatable balloon has an expansion of more than 25% and less than 200% when inflated from the un-inflated condition to a turgid condition, preferably more than 50% and less than 150%. In the turgid condition the polymeric material(s) of the balloon layers are at or near the elastic limit of the balloon layer material. The balloon may contain or be formed of or be coated with radiopaque material to facilitate positional or symmetry verification. | 2008-09-18 |
20080228026 | Method and apparatus for image enhanced external counterpulsation - An image enhanced external counterpulsation system may be used to monitor a continuous real-time ultrasound image of the patient's heart during ECP therapy. | 2008-09-18 |
20080228028 | WOVEN FABRIC WITH SHAPE MEMORY ELEMENT STRANDS - The disclosure relates to a woven fabric for use in an implantable medical device. The woven fabric comprises shape memory element strands woven with textile strands. At least one of the shape memory element strands has at least one float of at least five textile strands between binding points. | 2008-09-18 |
20080228029 | OVER-TUBE, METHOD OF MANUFACTURING OVER-TUBE, METHOD OF DISPOSING OVER-TUBE, AND METHOD OF TREATMENT IN ABDOMINAL CAVITY - An over-tube for use in an endoscopic treatment in an abdominal cavity using an endoscope includes an over-tube main body which is inserted from a distal portion thereof via a natural opening in a patient's body to access the inside of the abdominal cavity from the distal portion through a lumen wall, and an internal cover which is disposed in a passage of the endoscope disposed in an inner cavity of the over-tube main body and which is extractable from a proximal portion of the over-tube main body. | 2008-09-18 |
20080228030 | ARTICLE, SYSTEM, AND METHOD FOR SECURING MEDICAL DEVICES TO TREAT OBESITY, GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) AND IRRITABLE BOWEL SYNDROME (IBS) REVERSIBLY - A medical staple formed from a nitinol wire, the staple having two elongated arms which extend upwardly and outwardly from a central loop in two opposing generally semicircular courses forming an arc extending upwardly and outwardly and an end second comprising a sharpened endpoint, the endpoint being the arms bendable under resistance, is disclosed. In some embodiments the arms extend upwardly on a parallel course and then outwardly. The material is preferably an alloy with hyperelastic characteristics. The staples are placed in a flexible endoscope and a lumen catheter within the endoscope, using a hook or forceps in the lumen catheter having a distal end in the lumen of the catheter and the staple distal to the forceps in folded configuration with the arms folded inward in the lumen catheter, positioning the distal end of the lumen catheter at a location in the patient's gastrointestinal tract where stapling is desired, moving the forceps distally so as to force the staple forward out of the lumen catheter and cause the end points to pierce the patient's inner wall of the gastrointestinal tract. | 2008-09-18 |
20080228031 | System and Method for an Illumination-Quality Test - An endoscopic illumination tester is provided for testing illumination quality of a lightsource. The endoscopic illumination tester includes an optical bridge that is removably interlockable with the lightsource. The endoscopic illumination tester includes an integrating sphere that is removably interlockable with the optical bridge. The endoscopic illumination tester may further engage a lightguide connectable between the optical bridge and the lightsource. An endoscope may be inserted between the optical bridge and the integrating sphere. | 2008-09-18 |
20080228032 | CARDIAC VISUALIZATION DEVICES AND METHODS - Devices and methods for facilitating transvascular, minimally invasive and other “less invasive” surgical procedures generally include a sheath with an expandable balloon at the distal end, an inflation lumen for expanding the balloon, and a device passage lumen for allowing passage of one or more surgical instruments. The sheath is configured to house at least one visualization device such that an optical element of the device is positioned to view the surgical site. In some embodiments, instruments may be passed through the sheath, with the distal balloon partially or fully circumscribing or encircling the instruments. Any suitable instrument(s) may be passed through sheaths of the invention, such as a surgical clip applier for repairing a heart valve, an ablation member for treating atrial fibrillation, one or more pacemaker leads, a coronary sinus access device or the like. | 2008-09-18 |
20080228033 | Optical Coherence Tomography Probe Device - Optical coherence tomograph (OCT) probe device ( | 2008-09-18 |
20080228034 | ENDOSCOPE APPARATUS - An endoscope apparatus comprises: an endoscope including an insertion section; a cylindrical insertion assisting tool that allows the insertion section to be inserted to assist insertion of the insertion section into a body cavity; and a ring-shaped seal member that is supported so as to slide on the insertion section with the insertion section inserted, wherein the seal member is detachably mounted on a base end of the insertion assisting tool to seal a gap between the insertion assisting tool and the insertion section. | 2008-09-18 |
20080228035 | ENDOSCOPE AND HYDROPHILIC CAP - An endoscope includes: an insertion portion including a distal end portion, to be inserted into a subject; an observation optical system disposed in the insertion portion; an optical member configuring a part of an outer surface of the distal end portion, through which a photographing light to be incident into the observation optical system transmits; a first hydrophilic portion that is film-formed at least on a surface of the optical member; a second hydrophilic portion that is film-formed on a first surface of the distal end portion in which the optical member is disposed; and a third hydrophilic portion that is film-formed on a second surface separate from the first surface of the distal end portion. | 2008-09-18 |
20080228036 | ENDOSCOPE APPARATUS - An endoscope apparatus includes an apparatus main body having a housing with a concave portion formed in one surface, and an endoscope unit including a detachable connector portion in the concave portion, wherein, when the connector portion is mounted to the concave portion, the connector portion constitutes a part of the one surface. More preferably, a packing is provided in the housing or the connector portion that, when the connector portion is mounted to the housing, retains the mutual mating surfaces of the housing and the connector portion in a closely contacting state. | 2008-09-18 |
20080228037 | COMPACT FLUORESCENCE ENDOSCOPY VIDEO SYSTEM - A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes. | 2008-09-18 |
20080228038 | Illumination Assembly For Use With Vaginal Speculum Apparatus - An illumination assembly for use with a vaginal speculum includes an assembly housing containing a light source, such as at least one LED or incandescent lamp. The illumination assembly, which can be battery powered or powered by means of a dedicated power supply, such as an AC power supply, is configured to be fitted within a receiving cavity of a handle portion of a vaginal speculum. | 2008-09-18 |
20080228039 | Semi-passive method and system for monitoring and determining the status of an unattended person - A method and system for determining the status and monitoring an unattended individual. A radio beacon device can be associated with one or more individuals (e.g., an unattended person). Behavioral information about the individual(s) can be collected by tracking the location of the individual within a particular area (e.g., home, assisted living facility, etc.) utilizing the radio beacon device. The presence of other persons can then be distinguished from that of the individual within said particular area utilizing said behavioral information collected about said individual, thereby permitting a determination of the status of said individual and distinguishing the presence of other persons within said particular area. The behavioral information can include, for example, one or more activity levels associated with the individual. | 2008-09-18 |
20080228040 | International medical expert diagnosis - The delivery of services internationally has been stressful for consumers for several decades based on a lack of physical resources and increasing needs of individuals. Health care service delivery has been under close scrutiny since most countries cannot define viable alternatives to care for it population. Optimized Intelligent Search technology affords an opportunity to provide expert system caliber services on PDA and other computer platforms internationally based on leveraging unparalleled search capability, leveraging of decades of past history in seconds and provides optimized processes implementation for efficient use of resources. | 2008-09-18 |
20080228041 | Method and System for Remote Diagnosis and Supervision of Complex Procedures - A network enabled method and system for better utilizing expert or licensed individuals to address or treat a greater quantity of situations at a lower cost and at greater convenience allowing numerous companies to have access to such expert or liscensed resources. This business model involves a trained assistant gathering appropriate data and transmitting it to a central or remote location where the specialist can review it and transmit a diagnosis or directions to the assistant to execute. The expert then collects the fees for the procedure and distributes proceeds to the assistant, assistants company or coordinating third party. | 2008-09-18 |
20080228042 | DEVICE FOR COMMUNICATION - In a device, a method and a system for communication between a control module that can be associated with a local console of a medical modality, an examination module that can be associated with the medical modality, and an administration module that can be associated with an administration entity remote from the medical modality, respective communication units that can be connected among one another are associated with each of the modules and the signals transferred from a respective communication unit are transferred to the communication unit of at least one other module; and the communication unit of the administration module of the remote administration entity can access data of the medical modality. | 2008-09-18 |
20080228043 | Diagnosis Determination and Strength and Weakness Analysis - A method, software, database and system for diagnosing various phenotypes including illnesses, conditions, physical traits and features, and characteristics such as strengths and weaknesses of an individual are presented in which an attribute profile containing genetic and non-genetic attributes associated with an individual can be compared against a database containing combinations of genetic and non-genetic attributes that are statistically associated with the phenotypes in order to determine the potential that the individual currently possesses or will eventually develop one or more of the phenotypes. | 2008-09-18 |
20080228044 | Individually Activated Sensors for Implantable Sensors - An apparatus for managing and monitoring a sensing device encapsulated in a compartment formed within a medium is disclosed. The medium compartment includes a release mechanism ( | 2008-09-18 |
20080228045 | Multiprotocol Wireless Medical Monitors and Systems - A wireless medical monitoring system and medical monitoring devices adapted to communicate using a plurality of wireless protocols and networks. For each transmission of data, a wireless protocol or network is selected based on the properties of the available protocols and networks and the nature of the data that is to be transmitted. Thus, the medical system and devices can move seamlessly from one context and location to another. The medical devices may also include additional features, such as detection of improperly positioned or disconnected sensors and auditory and/or visual prompting of the patient to correct the problem. In some embodiments, the medical monitoring devices may comprise body area networks of individual sensors communicating and cooperating with one another wirelessly. | 2008-09-18 |
20080228046 | HEALTH CARE SUPPORT SYSTEM - The present invention provides a health care support system that can give appropriate advice depending on a situation. | 2008-09-18 |
20080228047 | MICRO-REMOTE GASTROINTESTINAL PHYSIOLOGICAL MEASUREMENT DEVICE - A physiological sensor-transmitter assembly for measuring a physiological property at an internal body location of a subject over time is described. An instrument for inserting the assembly in the subject and a method of monitoring a physiological property measured at the internal body location over time are also described. The assembly includes a sensor and a transmitter adapted to transmit information from the sensor in a non-wired fashion to a receiver. The assembly also includes an anchor adapted to attach to an externally accessible portion of a subject and a tether that connects the sensor and the anchor to maintain a position of the sensor within the gastrointestinal tract of the subject. | 2008-09-18 |
20080228048 | Physiological Sensors with Telemonitor and Notification Systems - Systems and methods are provided which enable communications to be initiated locally relative to an individual's developing physiological condition and remotely as the condition requires. Physiological sensors and associated medical delivery systems can be coupled to a unit wearable by an individual which can provide various audible or visual outputs and one or more manual inputs indicative of the individual's condition. A global positioning unit can be incorporated so that condition information as well as location information can automatically be provided, wirelessly, to a remote monitoring system for follow up as needed. | 2008-09-18 |
20080228049 | Systems, Circuits and Apparatus For In Vivo Detection of Biomolecule Concentrations Using Fluorescent Tags - Systems are disclosed wherein labeled binding molecules can be provided in vivo to tissue having biomolecules that specifically bind the labeled binding molecule. A first optical radiation is emitted into the tissue in vivo to excite the labeled binding molecule bound to the biomolecule in vivo. A second optical radiation that is emitted by the excited labeled binding molecule, in response to the excitation thereof, can be detected in vivo. Related telemetric-circuits and apparatus are also disclosed. | 2008-09-18 |
20080228050 | Noninvasive in vivo measuring system and noninvasive in vivo measuring method by correcting influence of Hemoglobin - A noninvasive in vivo measuring system and a noninvasive in vivo measuring method are provided. In the noninvasive in vivo measuring system, a Raman-fluorescence measuring unit measures blood sugar concentration, which is measured using Raman spectra before and after applying a pressure on a finger, and outputs a final blood sugar level by correcting the blood sugar concentration measurement according to a Hemoglobin (Hb) concentration measured by an Hb measuring unit. | 2008-09-18 |
20080228051 | ANALYTE MEASURING DEVICE - An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device. | 2008-09-18 |
20080228052 | Physiological trend monitor - A physiological trend monitor has a sensor signal responsive to multiple wavelengths of light transmitted into a tissue site. The transmitted light is detected after attenuation by pulsatile blood flow within the tissue site. A processor has an input responsive to the sensor signal and a physiological parameter output. Features are extracted from the physiological parameter output. Criteria are applied to the features. An alarm output is generated when the criteria are satisfied. | 2008-09-18 |
20080228053 | METHOD AND SYSTEM FOR CEREBRAL OXYGENATION LEVEL MONITORING - Methods, systems, and related computer program products are provided for the reliable measurement of absolute chromophore concentrations in biological tissue, such as those indicative of blood oxygenation levels in the brain, based on infrared optical scanning. A plurality of probe patches is positioned at a respective plurality of locations around the patient's head, each probe patch being positioned against the skin of the head, wherein at least one of the probe patches is positioned where the skin includes active hair follicles. Each probe patch comprises a first infrared source-detector pair having a relatively short source-detector spacing and a second infrared source-detector pair having a relatively long source-detector spacing. Phase-only measurements are acquired for each of a plurality of infrared radiation wavelengths and modulation frequencies for each source-detector pair. Absolute regional chromophore concentrations in the brain are computed based on the phase-only measurements. | 2008-09-18 |
20080228054 | ANALYTE MEASURING DEVICE - An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device. | 2008-09-18 |
20080228055 | Fluctuating Blood Glucose Notification Threshold Profiles and Methods of Use - Embodiments of the present invention provide a new system and methods for monitoring blood glucose concentration. A user of a continuous glucose monitor may program upper and lower blood glucose notification thresholds to fluctuate over time in order to facilitate management of the short-term effects of food consumption, insulin delivery aberrations, physical activity, emotions, and unforeseen circumstances. | 2008-09-18 |
20080228056 | BASAL RATE TESTING USING FREQUENT BLOOD GLUCOSE INPUT - An apparatus comprising a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration during delivery of insulin according to a specified basal insulin rate pattern, and a controller communicatively coupled to the input and the user interface. The controller includes an insulin calculation module configured for determining at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline. Other devices and methods are disclosed. | 2008-09-18 |
20080228057 | Method and system for controlling data information between two portable apparatuses - Disclosed is a method and system of controlling data information between two portable handheld apparatuses where the portable apparatuses include a first apparatus for performing a first operation and a second operation, and a second apparatus including a drug administration device. Each apparatus is capable one or more of the following: storing, transmitting, receiving, processing and displaying data information, and where the two apparatuses have a number of interrelated positions during normal use, where the method includes: automatically storing at least first data information relevant to said first operation in said first apparatus, automatically storing at least second data information relevant to said second operation in said second apparatus, and automatically transmitting, via short-range communications means, data information relevant to at least one of said first and second operations between said first and second apparatuses when said apparatuses are mutually positioned in one of said number of interrelated positions. | 2008-09-18 |
20080228058 | Apparatus and Method for Detecting the Reproductive Status, in Particular the Oestrus Cycle, of a Mammal - An apparatus for detecting the reproductive status, in particular the oestrus cycle, of a mammal, comprising detecting means ( | 2008-09-18 |
20080228059 | ELECTRICAL CONNECTOR FOR AN IN-BODY MULTI-CONTACT MEDICAL ELECTRODE DEVICE - An improved electrical connector for connecting a multi-contact medical electrode device with a plural-contact tail. Having a tail-receiving first elongate member with a tail-receiving void and a second elongate member. The second elongate member has a nesting surface and an array of electrical conductors which are spring-loaded pin plunger devices. The spring-loaded pin plunger devices having movable pins that project into and at least partially, preferably halfway, across and into the tail-receiving void. The device is configured such that the spring-loaded pin plunger devices extend at an angle substantially parallel to the movement of the tail-receiving void at the point the pin tips enter therein. The distal end of the second elongate member has an opening through which a multi-wire electrical cable extends. The second elongate member also has a channel in alignment with the opening that has therein the multiple wires of the electrical cable. | 2008-09-18 |
20080228060 | HIGH DENSITY MAPPING CATHETER - The present invention is directed to a high density mapping catheter including a number of shape memory electrode fibers and associated methods of construction ad operation. The invention ensures good electrical contact between a large number of mapping electrodes and cardiac tissue in relation to a number of cardiac tissue approach angles, including head-on approaches. In addition, the invention allows for a reduced range of deflection angles in relation to deployment and retraction of the electrode fibers, thereby reducing resistance to retraction and reducing stress on the fibers and associated concerns regarding patient safety. The catheter of the present invention allows for rapid acquisition of a large amount of mapping data and allows for a variety of different geometries in relation to sweeping of the catheter across the cardiac tissue. | 2008-09-18 |
20080228061 | Method and Apparatus Providing Flexible Measurement Functionality for Medical Images - In a medical imaging system the flexibility and power of measurement tools is improved by making the measurements objects themselves, whereby flexible interaction is provided. The measurement objects ( | 2008-09-18 |
20080228062 | High Resolution Radio Frequency Medical Imaging and Therapy System - A method for imaging includes directing a plurality of radio frequency (RF) beams ( | 2008-09-18 |
20080228063 | System and method for irradiating a target with electromagnetic radiation to produce a heated region - A system and corresponding method for irradiating a target with electromagnetic radiation to produce a heated region. The system comprises a coupling device operable to couple electromagnetic radiation from a magnetic resonance imaging system. A plurality of energy radiator applicators are connected to the coupling device to receive electromagnetic radiation energy from the coupling device. Each of the radiator applicators is operable to emit a radio frequency heating signal using the electromagnetic radiation energy from the coupling device. A bolus filled with a dielectric fluid is positioned within the inner area of the MRI system. The bolus is operable to receive the radio frequency heating signals from the plurality of energy radiator applicators and direct the radio frequency heating signals into a section of the body to produce a heated region within the body. | 2008-09-18 |
20080228064 | Marker Tracking for Interventional Magnetic Resonance - A fiducial marker assembly ( | 2008-09-18 |
20080228065 | System and Method for Registration of Localization and Imaging Systems for Navigational Control of Medical Devices - A system and method are provided for obtaining registration of a localization system's three-dimensional coordinates for a plurality of markers having known locations to the two-dimensional coordinates for the plurality of reference markers obtained from a single X-ray image. The method for registering a navigational system with a localization system having a plurality of reference markers includes determining the three-dimensional coordinates of the locations of a plurality of reference markers within the localization coordinate system, and providing a single two-dimensional X-ray image that includes a two dimensional location of the plurality of markers. The method further includes determining a coordinate transformation for obtaining a best fit registration of the localization system's three-dimensional coordinates to the two-dimensional coordinates obtained from the single X-ray image, for at least one reference marker location. | 2008-09-18 |
20080228066 | METHODS AND SYSTEMS FOR LOCATING A FEEDING TUBE INSIDE OF A PATIENT - Systems and methods are provided for detecting the position of a feeding tube in a patient's body. A feeding tube having a light source sensor is inserted into a patient. A light is generated over the body of a patient. When the light source sensor detects the presence of the light, a signal is generated. In certain embodiments, the signal may be based upon the intensity of the light perceived at the light source sensor. Certain embodiments provide systems and methods comprising a feeding tube having a proximity sensor target. A detector having a proximity sensor is moved externally about a patient's body such that, when the sensor detects the proximity sensor target of the feeding tube, the proximity sensor produces an indication signal. | 2008-09-18 |
20080228067 | Rendering Method and Apparatus - A rendering method uses volumetric data ( | 2008-09-18 |
20080228068 | Automated Surgical Navigation with Electro-Anatomical and Pre-Operative Image Data - A method for navigating a medical device to an anatomical surface within a subject to perform electro-anatomical mapping using a magnetic navigation system is provided that includes importing a pre-operative image data set of an anatomical surface in the subject's body into a localization system. One or more control parameters are applied to the magnetic navigation system to drive the medical device to one or more points of tissue contact, from the locations of which a geometric anatomical map can be created and registered with the pre-operative anatomical image. The pre-operative anatomical surface image and a representation of the geometric anatomical map are displayed relative to one another, such that a user may select a location on the displayed pre-operative anatomical image to navigate the medical device towards. The localization system provides the location data to the magnetic navigation system to drive the medical device to the desired location, for enabling further electrophysiology mapping or ablation treatment. | 2008-09-18 |
20080228069 | Novel Differential Imaging Method - The present invention relates to an improved method of imaging cardiac neurotransmission in vivo in a human subject using adrenergic imaging agents. The method comprises obtaining two separate images with the same adrenergic imaging agent. One of the images is obtained in conjunction with the administration of a compound known to interfere with the uptake of the particular imaging agent in question. Comparison of the two images enables additional information to be obtained in relation to the status of cardiac neurotransmission in said subject compared with imaging with adrenergic imaging agent alone. The invention also provides a method of imaging cardiac neurotransmission in a human subject in vivo wherein a single image is obtained using an adrenergic imaging agent in conjunction with the administration of a non-pharmaceutical dose of an agent known to interfere with the uptake of the imaging agent. The invention furthermore provides a method of operating an imaging apparatus, a second medical use of an adrenergic imaging agent as well as a kit suitable for carrying out the methods of the invention. | 2008-09-18 |
20080228070 | Adaptive Contrast Agent Medical Imaging - System parameters for contrast agent medical imaging are conveniently set. A simplified contrast agent configuration is provided where an appropriate contrast agent detection technique and/or contrast agent imaging parameters are achieved consistently and more often then exists with current methods. Examination workflow is improved for contrast agent studies by offering one contrast agent imaging mode or configuration that is dynamically determined and optimized based on the user's selected transmit level and/or a real-time measurement of the contrast agent signals. A simplified user interface provides one contrast agent imaging mode without a need to switch between multiple modes or contrast agent detection techniques and associated contrast agent imaging parameters. The contrast agent detection technique and imaging parameters are adjusting or selected based on changes in the transmit levels for contrast agent imaging. Either a single user input control or real time measurements are used to select a transmit level, resulting in automatic selection of adjustment of the detection technique and/or imaging parameters. Appropriate contrast agent detection techniques and imaging parameters are selected for each given transmit level without the user having to switch the mode or configuration of the system during an imaging session. As a result, contrast agent examinations are simplified while minimizing suboptimal selection by a user. | 2008-09-18 |
20080228071 | Diagnostic Ultrasound System with Grippable Articulating Flat Panel Display - An ultrasonic diagnostic imaging system includes an articulating flat panel display for viewing images produced by the ultrasound system. The flat panel display is articulated to a desired viewing position by gripping the periphery of the display screen and moving the display screen to the desired viewing position with one hand. The bezel around the display screen is contoured and formed of a robber-like material which can be engaged with the thumb of a user's hand, and the back of the display enclosure opposing the bezel contains perforations which can be engaged with fingers of the user. The gripping perforations also provide ventilation of the flat panel display. | 2008-09-18 |
20080228072 | Foreign Body Identifier - A surgical instrument for the presence and/or location of a foreign body is disclosed. The surgical instrument is hand-held. In some embodiments, the surgical instrument includes transducers adapted for emitting and/or receiving signals. In such embodiments, the surgical instrument utilizes pulse-echo measurements to determine characteristics and/or location of the foreign body. In other embodiments, the surgical instrument includes a measurement circuit for detecting the presence and/or location of a foreign body by a change in the characteristics of the measurement circuit. The surgical instrument may be utilized to determine such things as the size of a foreign body, the orientation of a foreign body with respect to patient anatomy and/or another foreign body, and whether the foreign body has been completely removed. | 2008-09-18 |
20080228073 | SYSTEM AND METHOD FOR OPTOACOUSTIC IMAGING OF PERIPHERAL TISSUES - The system and method for optoacoustic imaging of peripheral tissues provides an assembly for emitting radiation on a tissue and an OCT system coupled to said assembly. The OCT system images tissue concurrent with the emission of radiation on the tissue. | 2008-09-18 |
20080228074 | SYSTEM AND METHOD FOR MEASURING ACOUSTIC PRESSURE AT MULTIPLE LOCATIONS SIMULTANEOUSLY - The present invention provides a system and method for measuring acoustic pressure at multiple locations simultaneously. An array transducer device is prepared where a polyimide film is bonded to a piezopolymer membrane using a non-conductive epoxy. The polyimide is etched with a linear array pattern having array elements, connection pads and electrical connections connecting the array elements to the connection pads. The array pattern is electronically accessed by linking traces of a customized printed circuit board to the electrical connections of the array pattern via ZIF connectors. | 2008-09-18 |
20080228075 | Combination Imaging and Therapy Transducer With Therapy Transducer Amplifier - A combined ultrasound imaging and therapy transducer ( | 2008-09-18 |