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37th week of 2011 patent applcation highlights part 42
Patent application numberTitlePublished
20110223610Two secretory luciferases - The present invention is one gene construct or a combination of two gene constructs or expression vectors incorporating a 2011-09-15
20110223611LENALIDOMIDE AND THALIDOMIDE IMMUNOASSAYS - Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids.2011-09-15
20110223612Magnetic Sensor Based Quantitative Binding Kinetics Analysis - Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.2011-09-15
20110223613METHOD OF IMAGING BY MASS SPECTROMETRY AND NEW MASS TAG ASSOCIATED TRITYL DERIVATIVES - The present invention concerns a method of analyzing at least one specific molecule in a sample using a compound of formula (I″) wherein Z binds specifically to said at least one specific molecule, Y is independently a cleavable single bond, linker atom or group, and R is independently a substituent such as H, C2011-09-15
20110223614TOXIN DETECTION METHOD - According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in 2011-09-15
20110223615Rapid Expression Cloning of Human Monoclonal Antibodies from Memory B Cells - The present application provides methods for producing human monoclonal antibodies without using hybridoma technology, antibodies produced used the described methods, and methods for using the antibodies to treat or prevent disease conditions (e.g., infection by pathogens such as the Human Immunodeficiency Virus).2011-09-15
20110223616HuR-Associated Biomarkers - The present invention relates to methods of identifying gene targets, including methods of using ribonucleoprotein (RNP) immunoprecipitation-microarrays to identify cancer gene targets, such as subsets of RNP-associated mRNAs in breast cancer cell lines. Also presented, are ribonucleotide binding protein-associated biomarkers, panels or sets of ribonucleotide binding protein-associated biomarkers, methods and compositions comprising ribonucleotide-binding protein, associated nucleotides, nucleotide arrays, and kits to facilitate the diagnosis of and monitoring the disease status or progression of treatment of breast cancers, including drug-resistant breast cancers.2011-09-15
20110223617IMMUNOASSAYS FOR AUTOANTIBODIES IN CARDIOVASCULAR DISEASES - The present invention relates to the quantitative measurement of auto-reactive antibodies in a patient sample. In particular, the present invention is directed to, inter alia, a method for predicting the degree of cardiovascular injury in a patient following an ischemic event, said method comprising: immobilizing anti-NMHC II antibody on a solid support; adding a lysate of cardiac tissue to the solid support so that antigens in the lysate are captured by the immobilized antibody; adding a biological sample from the patient to said solid support, and incubating said sample for a time sufficient for IgM autoantibodies in the biological sample to bind to antigens in the cardiac tissue lysate; contacting said solid support with an anti-IgM antibody; removing unbound labeled antibodies; and determining the level of anti NMHC II autoantibodies in the biological sample by measuring the amount of labeled anti-IgM antibody bound to the solid support, wherein elevated levels of anti-NMHC II autoantibodies compared to normal individuals at time of patient admission indicates an increased risk of injury. Such methods are useful, inter alia, in the prognosis and monitoring of cardiovascular diseases.2011-09-15
20110223618ASSAYS USING CHIMERIC T1R POLYPEPTIDE - This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.2011-09-15
20110223619COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS, AND METHODS OF USE - Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.2011-09-15
20110223620Method of detecting microorganisms and microorganism detecting apparatus - It is possible to determine the presence of bacteria in a sample solution in a shorter period of time without changing a conventional incubating method. Bacteria in a sample solution are incubated in, for example, a sterilized agar medium 2011-09-15
20110223621COMBINATIONS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS - The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.2011-09-15
20110223622Methods and Kits for Predicting the Onset of Labour - The present invention relates to methods and kits useful for predicting the time of onset of labour in a pregnant subject. In particular, the invention relates to methods and kits for predicting the time of onset of labour wherein the levels of at least two hormones, selected from estriol, estradiol and progesterone, are determined and a ratio of said levels is calculated, and wherein the time of onset of labour is predicted by comparison of said ratio with a predetermined ratio. The invention further contemplates methods for preventing preterm delivery of an infant/offspring.2011-09-15
20110223623METHODS FOR DIAGNOSING CANCER AND DETERMINING THE OVERALL SURVIVAL AND DISEASE-FREE SURVIVAL OF CANCER PATIENTS - The invention provides methods for prognosis of patients afflicted with cancer, comprising determining the level of GP88 expression in a biological sample obtained from said patient.2011-09-15
20110223624IMMUNOASSAY FOR DETECTION OF NEUROTOXIC AMINO ACID ASSOCIATED WITH NEUROLOGICAL DISORDERS - An immunoassay for screening a sample to detect the presence of β-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that binds to BMAA, and detecting the antibody bound to the sample, are disclosed. Immunoassays and kits for screening for the presence of BMAA in a subject by analyzing a tissue sample obtained from the subject to detect the present of BMAA in the tissue sample, where the presence of BMAA in the tissue sample indicates exposure of the subject to an environmental source of BMAA, are disclosed. Immunoassays and kits for detecting an environmental source of BMAA, by screening an environmental sample to detect the presence of BMAA in the sample, wherein the presence of a detectable amount of BMAA in the sample indicates the sample is an environmental source of BMAA, are disclosed.2011-09-15
20110223625BIOLUMINESCENT ASSAYS USING CYANOBENZOTHIAZOLE COMPOUNDS - The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.2011-09-15
20110223626METHOD FOR QUANTITATIVELY DETERMINING CHOLESTEROL IN LOW-DENSITY LIPOPROTEINS,REAGENT FOR QUANTITATIVE DETERMINATION,AND QUANTITATIVE DETERMINATION KIT - A method for measuring cholesterol in low-density lipoprotein contained in a sample, which comprises reacting a sample with (i) a combination of cholesterol ester hydrolase and cholesterol oxidase or (ii) a combination of cholesterol ester hydrolase, an oxidized coenzyme and cholesterol dehydrogenase in the presence of: [a] a polyoxyethylene-polyoxyalkylene alkylaryl ether; [b] one or more surfactants selected from the group consisting of a polyoxyethylene-polyoxyalkylene copolymer, a polyoxyethylene alkenyl ether, a polyoxyethylene branched alkyl ether, and a polyoxyethylene-polyoxyalkylene branched alkyl ether; [c] one or more surfactants selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, and a quaternary ammonium; and [d] a polyanion, and measuring a substance formed or consumed in the reaction.2011-09-15
20110223627MICROFLUIDIC FLOW ASSAY FOR MEASURING HEMOSTATIC PHENOTYPES - A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a micropatterned surface that induces clot formation and an array of microfluidic channels though which blood flows. The micropatterned surface contains two clotting stimuli, one for inducing platelet adhesion and another for inducing the coagulation cascade.2011-09-15
20110223628METHOD FOR THE IDENTIFICATION OF A RISK FOR A THROMBOGENIC DISORDER BY DETERMINING THE TAFl-lle347 POLYMORPHISM - The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.2011-09-15
20110223629METHOD FOR DETERMINATION OF DELTA-D VALUES OF NON- EXCHANGEABLE HYDROGEN STABLE ISOTOPES ON ETHANOL' S METHYL GROUP BY MEANS OF IRMS INSTRUMENTAL TECHNIQUE - The present innovation is related with chemical instrumental analysis, i.e. to the domain of analysis of stable isotopes in food products, and it is related to the method for preparation of ethanol samples and mode for determination of isotopic ratio of non-exchangeable hydrogen stable isotopes sited on the methyl site of ethanol by means of instrumental technique CF-TC/EA-IRMS (Continuous Flow-Temperature Conversion/Elemental Analyzer-Isotope Ratio Mass Spectrometry), and for the purpose of establishing authenticity and geographical origin of wine and grape must, beer, alcoholic beverages, fruit juices, honey, vinegars and other food products which contain alcohol and/or fermentable sugars. This method is based on full enzymatic (or organic) transformation of ethanol samples to gain ethanoic acid (acetic acid), controlled neutralization of acetic acid and further concentration, purification of prepared acetate salt and its drying to the constant mass and further determination of δD values in prepared samples by means of CF-TC/EA-IRMS.2011-09-15
20110223630METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION - Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.2011-09-15
20110223631Detection of microorganisms with a fluorescence-based device - A device and method for detecting by fluorescence microbial growth from sample substances are disclosed. For example, a method for the detection of visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising exciting said at least one fluorescing compound with ultraviolet energy emitted from a light-emitting diode comprising wavelengths below 2011-09-15
20110223632SMEAR STAINING APPARATUS, SMEAR PREPARING APPARATUS, SMEAR PROCESSING SYSTEM, AND METHOD FOR DETERMINING STAINING CONDITION - A smear staining apparatus comprising: a staining section which stains a smear sample with a quantity of stain fluid; and a controller, wherein the controller: receives information regarding a stain state on a smear sample which is stained according to a first staining condition by the staining section; and determines a second staining condition on the basis of the information and a target value which defines a targeted stain state, is disclosed. A smear preparing apparatus, a smear processing system and method for determining staining condition are also disclosed.2011-09-15
20110223633METHODS AND REAGENTS FOR ENRICHMENT AND CHARACTERIZATION OF PHOSPHORYLATED BIOMOLECULES - An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety of different applications, including phospho-biomolecule (e.g., phosphoprotein and phosphopeptides) enrichment/purification and characterization applications. Also provided are kits and systems that include the matrix.2011-09-15
20110223634TRANSFECTION KINETICS AND STRUCTURAL PROMOTERS - The invention features methods of analyzing the kinetics properties of transfection reactions. Also featured are methods for creating structural promoters which are effectively unregulated by enhancers and repressors. The structural promoters are significantly more active than the native promoter sequences upon which they are based.2011-09-15
20110223635Method and Composition for Controlling Gene Expression - A composition for expressing a protein in cells is provided. In certain embodiments, a circular expression vector provided herein comprises: a promoter, a coding sequence encoding a protein of interest, in which the coding sequence is in a reversed 3′-5′ orientation, a transcription termination sequence, and at least a first recombination site and a second recombination site flanking the coding sequence. A method for using the disclosed composition and a kit comprising the composition are also provided herein.2011-09-15
20110223636FLUORESCENT PROTEIN AND CHROMOPROTEIN - It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from 2011-09-15
20110223637METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL - The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2011-09-15
20110223638Methods of Generating Nucleic Acid Fragments - Provided herein are methods of using a Cas1 polypeptide to generate nucleic fragments from a DNA substrate. These methods may be performed in vitro or in vivo. Also provided are methods of screening for modulators of Cas1.2011-09-15
20110223639Process for Conversion of Granular Starch to Ethanol - The present invention concerns a method of producing glucose from a granular starch substrate comprising, contacting a slurry comprising granular starch obtained from plant material with an alpha-amylase at a temperature below the starch gelatinization temperature of the granular starch to produce oligosaccharides and hydrolyzing the oligosaccharides to produce a mash comprising at least 20% glucose and further comprising fermenting the mash to obtain ethanol.2011-09-15
20110223640IMPROVED STATIN PRODUCTION - The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin or simvastatin comprising culturing a host, preferably a filamentous fungus, comprising the polynucleotide of the lovE transcription regulator gene from 2011-09-15
20110223641MICROBIAL ENGINEERING FOR THE PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES - Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.2011-09-15
20110223642METHOD FOR INHIBITING BACTERIA GROWTH DURING ETHANOL FERMENTATION - The present invention is an antibacterial hop product used to inhibit the growth of gram positive bacteria in yeast propagators and ethanol producing fermenters. The hop product is an isomerized or stabilized hop made of alkaline earth metals or alkali earth metals. The antibacterial hop product also enhances the alcohol tolerance of yeast cells.2011-09-15
20110223643SYSTEM FOR BIONIC CATALYTIC HYDROLYZING CELLULOSE AND ITS USE IN PRODUCING LIQUID FUEL FROM CELLULOSE BIOMASS - A bionic catalyst for hydrolyzing cellulose and hemicellulose and its preparation method. The catalyst comprises double acid radical catalytic portions and cellulose-linking portions, and can be used under room temperature and high temperature. The catalyst can hydrolyze cellulose and hemicellulose simultaneously, while not decompose glucose and xylose, and may be recycled efficiently. The catalyst can be combined with the process in the prior art to produce liquid fuel.2011-09-15
20110223644Device for fuel and chemical production from biomass-sequestered carbon dioxide and method therefor - A process and apparatus for sequestering carbon and converting it to fuel, such as methane, and/or materials, such as fermentation substrates, biopolymers, bioplastics, oils, pigments, biochar, metals, such as mercury, chromium and arsenic, fibers, proteins, vitamins, fertilizers and animal feed. The apparatus comprises a deep well carbon-sequestering bioreactor coaxially located within a deep well anaerobic bioreactor. Carbon is sequestered into a photosynthetic biomass or a heterotrophic biomass, which is subsequently digested by an anaerobic biomass containing methanogenic microbes, whereby methane is a digestion product. Alternatively, the biomass can be subjected to physical-chemical treatment to produce oil and other useful byproducts.2011-09-15
20110223645Multivalent Carriers of Bi-Specific Antibodies - Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The targetable constructs and targetable complexes of the invention are incorporated into biosensors, kits and pharmaceutical compositions, and are used in a variety of therapeutic and other methods.2011-09-15
20110223646EXPRESSION OF SOLUBLE, ACTIVE EUKARYOTIC GLYCOSYLTRANSFERASES IN PROKARYOTIC ORGANISMS - The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.2011-09-15
20110223647GRG36: Novel EPSP Synthase Gene Conferring Herbicide Resistance - Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, the present invention provides for isolated nucleic acid molecules comprising the nucleotide sequence set forth in SEQ ID NO:1, 3, 4, 6, 7, 9, 10, 12, 13, 15, 17, 18, 20, 21, or 23, a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:2, 5, 8, 11, 14, 16, 19, or 22, the herbicide resistance nucleotide sequence deposited in a bacterial host as Accession Nos. NRRL B-30932, B-30933, B-30934, B-30945, B-30946, B-30947, or B-30948, as well as variants and fragments thereof.2011-09-15
20110223648DIRECTED EVOLUTION OF GRG31 EPSP SYNTHASE ENZYME - Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides encoding glyphosate resistance or tolerance polypeptides are provided, particularly polypeptide variants of SEQ ID NO:2 and 4. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides containing nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:7-28, or the nucleotide sequence set forth in SEQ ID NO:29 or 30.2011-09-15
20110223649RECOMBINANT CELL TRANSFORMED BY AN ARABIDOPSIS THALIANA ATPASE ATHMA1 SEQUENCE - This invention corresponds to a bacteria or preferably a yeast, which in its natural state presents a reduced tolerance to heavy metals, but when genetically transformed following this invention, with a vegetal-origin gene, presents high tolerance to heavy metals. Specifically, the cell in the invention is transformed with a vector that allows the expression of the AtHMA-1 gene of 2011-09-15
20110223650Modular Membrane Reactor and Process for Carbon Dioxide Extraction - The present invention relates to a reactor and a process suitable for extracting carbon dioxide from carbon dioxide-containing gas stream. The reactor is based on a two module system where absorption occurs in one module and desorption occurs in the other module. The carbon dioxide extraction may be catalyzed by carbonic anhydrase.2011-09-15
20110223651APPARATUS FOR TESTING ELECTRICAL ACTIVITY FROM A BIOLOGICAL TISSUE SAMPLE - An apparatus (2011-09-15
20110223652PIEZOELECTRIC-BASED NANOPORE DEVICE FOR THE ACTIVE CONTROL OF THE MOTION OF POLYMERS THROUGH THE SAME - Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the membrane. The membrane comprises electrical conductive layers, piezoelectric layers, and insulating layers. The piezoelectric layers are operative to control a size of the nanopore for clamping/releasing a polymer as well as to control the thickness of part of the membrane when a voltage is applied to the piezoelectric layers. Combinations of clamping/releasing the polymer and changing the thickness of part of the membrane can move a polymer through the nanopore at any electrically controlled speed and also stretch or break a polymer in the nanopore.2011-09-15
20110223653Method and apparatuses for sorting objects in forensic DNA analysis and medical diagnostics - The present invention relates to an apparatus and method of sorting objects and identifying the objects in a forensics sample, including using holographic optical trapping to sort objects from contaminants, and performing (single cell) PCR-based STR analysis on the objects to determine their identification. In addition, the chip used as a support for sorting the objects can also be used for performing single cell PCR-based STR analysis. In another embodiment, a microfluidics chip is used to stream the sample and sort the objects, before single cell PCR-based STR analysis is performed. The chip used for sorting utilizing HOT in the absence or presence of microfluidic streaming and sorting can also be the same as that used for the single cell PCR-based STR analysis.2011-09-15
20110223654NANO-MICROFLUIDIC APPARATUS FOR CONTINUOUS REAL-TIME ANALYSIS OF TARGETS IN THIN LIQUID FILMS - Nano-microfluidic devices and uses thereof are described. In particular, systems and methods are described for continuous real-time monitoring and analysis of targets in thin liquid films; such targets can include living cells and tissues. In some embodiments, nano-microfluidic devices can be utilized to observe living cells in layers of thin liquid media by IR-spectroscopy.2011-09-15
20110223655System for Measuring and Analyzing Properties of Water and Sediment Samples - A system for assessing the characteristics and toxicity of a water sample comprising: a test chamber; an optical signal generator configured to emit an optical signal into the test chamber; a first digital filter disposed between the optical signal generator and the test chamber; a first optical transducer disposed to generate a first data signal in response to detecting radiant energy in the test chamber; a second digital filter disposed between the first optical transducer and the test chamber; an aqueous suspension of dinoflagellates contained within the test chamber and mixed with the water sample; a stimulator disposed to stimulate the dinoflagellates to emit a bioluminescence signal; and a microprocessor operatively coupled to the optical signal generator, the first digital optical filter, the stimulator, the first optical transducer, and the second digital filter, wherein the microprocessor is configured to assess the spectral characteristics and toxicity of the water sample.2011-09-15
20110223656MicroRNAs and Uses Thereof - Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.2011-09-15
20110223657TRP/HIS EXCHANGE AND KYNURENIN INDUCED TRP TRANSPORT - The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.2011-09-15
20110223658MONOCLONAL ANTIBODIES WITH ENHANCED ADCC FUNCTION - The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP)2011-09-15
20110223659Compositions And Methods For Detecting Severe Acute Respiratory Syndrome Coronavirus - The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.2011-09-15
20110223660COMPOSITIONS FOR INDUCING DIFFERENTIATION INTO RETINAL CELLS FROM RETINAL PROGENITOR CELLS OR INDUCING PROLIFERATION OF RETINAL CELLS COMPRISING WNT SIGNALING PATHWAY ACTIVATORS - Disclosed is a composition for inducing the proliferation of retinal cells or the differentiation of retinal progenitor cells into retinal cells. The composition, similar to in vivo conditions for development during embryogenesis, induces stem cells to differentiate into a multitude of photoreceptor cells at high yield within a short period of time, without an additional gene transfer. In addition, the differentiated photoreceptor cells are useful in cellular therapy because they, when transplanted into degenerated or injured retinas, can be engrafted and fused within the retinas to prevent or cure retinal degeneration.2011-09-15
20110223661INHIBITORS OF STAT3 - Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R2011-09-15
20110223662COMPOSITION FOR PRESERVING PLATELETS AND METHOD OF USING THE SAME - The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.2011-09-15
20110223663COMPOSITION FOR PRESERVING PLATELETS AND METHOD OF USING THE SAME - The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.2011-09-15
20110223664MATERIALS AND METHODS OF INTRODUCING GENETIC MATERIAL INTO LIVING CELLS - The present invention generally relates to introducing genetic material to living cells. In some embodiments, the present invention relates to compositions of matter for targeted delivery of nucleic acids to cells. In other embodiments, the present invention relates to methods of targeted delivery of nucleic acids to cells. In still other embodiments, the present invention relates to polymers that contain at least one amino acid in their backbone. In yet other embodiments, the present invention relates to polymers that contain at least one amino acid in their backbone thereby resulting in biodegradability, and in some embodiments, controlled biodegradability.2011-09-15
20110223665ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND - One aspect of the present invention relates to a double stranded nucleic acid useful as an siRNA, that has a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one nucleoside comprising a non-natural nucleobase. Another aspect of the invention relates to a method of gene silencing, comprising administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand.2011-09-15
20110223666CYTOPLASM EXPOSURE ADDITIVE AND METHOD FOR EXPOSING PARTICLES DELIVERED INTO CELL TO CYTOPLASM FROM ENDOCYTIC VESICLES IN INTACT CELL - The present invention relates to a method of exposing particles to cytoplasm comprising introducing particles into a live cell; allowing the live cell to contact a cytoplasm exposure additive which can expose the particles from endocytic vesicles to cytoplasm in the cell with maintaining its physiological, biochemical, or biological environment as undamaged; and allowing the particles to be exposed from the endocytic vesicles to the cytoplasm. The present invention is advantageous in that particles delivered into cells can be effectively exposed to cytoplasm from endocytic vesicles in intact cells which maintain their physiological, biochemical, or biological environment as undamaged.2011-09-15
20110223667METABOLIC ENGINEERING OF LIPID METABOLISM BY IMPROVING FATTY ACID BINDING AND TRANSPORT - CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.2011-09-15
20110223668Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) - The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.2011-09-15
20110223669METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells, comprising inhibiting the p53 function in the step of somatic cell nuclear reprogramming. The inhibition of p53 function is achieved by bringing a substance selected from the group consisting of (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors, into contact with a somatic cell, and the like. The present invention also provides an agent for improving the efficiency of establishment of iPS cells, the agent comprising an inhibitor of p53 function, particularly (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors. The present invention further provides a method of producing an iPS cell, comprising bringing a nuclear reprogramming substance and an inhibitor of p53 function into contact with a somatic cell.2011-09-15
20110223670ETS2 AND MESP1 GENERATE CARDIAC PROGENITORS FROM FIBROBLASTS - A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.2011-09-15
20110223671Methods for using positively and negatively selectable genes in a filamentous fungal cell - The present invention relates to methods for using positively and negatively selectable genes in a filamentous fungal cell to delete, disrupt, or insert a gene in a filamentous fungal cell.2011-09-15
20110223672INTEGRATED METHODS FOR CORROSIVITY, AGEING AND FINGERPRINTING DETERMINATION, AS WELL AS DIAGNOSIS, DECONTAMINATION, DEPOLARISATION AND DETOXIFICATION OF OILS - The methods of the invention are aimed toward the determination of corrosivity, ageing, fingerprinting and contaminants, as well as the functional diagnosis, decontamination, depolarisation and detoxification of oils and technical fluids, such as mineral insulating, natural and/or synthetic esters, lubricants, hydraulic fluids, diathermic fluids and technical fluids in general, used in apparatuses and equipment, such as electric transformers, reactors, bushings, switches and turbines, for the generation, transmission, distribution and use of power.2011-09-15
20110223673Polarized Optics for Optical Diagnostic Device - A readhead for a photometric diagnostic instrument includes a holder configured for receiving reagent sample media therein. The sample media has a plurality of test areas configured to react with, and change color, according to an amount of an analyte in a sample. The holder is sized and shaped for forming an indexed fit with the sample media. One or more light sources are configured to emit light onto the test areas. First and second polarized light filters are respectively disposed between the light sources and the test areas, and between the test areas and one or more light detectors, so that the light detectors receive diffuse, non-specular reflections of the light from the test areas, while substantially preventing the light detectors from receiving specular reflections of the light.2011-09-15
20110223674ANALYTICAL INSTRUMENT - An ion mobility spectrometer analytical instrument, including an ion mobility spectrometer, a swab interface, and a desorber assembly. The desorber assembly includes a heat transfer device configured to heat a desorber, as well as a supply configured to direct gas through the desorber. The instrument further includes a drift tube, high voltage device arrayed, at least in part, proximate to the drift tube, wherein the high voltage device is configured to change a polarity of a voltage applied to the drift tube and have an absolute voltage of about 500 to 1500 volts. The instrument further includes a reactant supply unit adapted to supply reactant during a sample substance analysis, and a control unit.2011-09-15
20110223675DRUG RELEASE MEANS FROM LIPOSOMES AND METHOD FOR EVALUATING RELEASABILITY - Drug release means from liposomes and a method for evaluating drug releasability of liposome preparations, which are useful for the quality control of a liposome preparation, are simple, accurate and excellent in reproducibility and are able to achieve in vivo/in vitro correlation (IVIVC), are provided. The drug release means from liposomes by causing the shift of chemical equilibrium in the inside of the liposome and the method for evaluating drug releasability by quantitatively determining the drug released to the outside of the liposome.2011-09-15
20110223676DNA-BASED MOLECULAR SWITCHES AND USES THEREOF - Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic pH. Also disclosed are compositions and methods for measuring the pH of cells or regions thereof, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen.2011-09-15
20110223677CARBOXAMIDE-SUBSTITUTED DYES FOR ANALYTICAL APPLICATIONS - The present invention relates to carboxamide-substituted dyes, the production and use of such dyes as labeling groups in analytics.2011-09-15
20110223678CALIBRATION SYSTEM AND TECHNIQUE FOR PHOTOLUMINESCENT OXYGEN SENSORS WITH ZERO POINT MAINTAINED WITH A METAL-AIR BATTERY - A calibration device and method of using the device to calibrate an analytical instrument capable of reading a photoluminescent oxygen probe. The device includes at least (a) a first mass of an oxygen sensitive photoluminescent dye retained within a hermetically sealed space so as to isolate the dye from environmental oxygen, and in fluid communication with an activated metal-air battery whereby any oxygen permeating into the hermetically sealed space is quickly consumed by the battery, and (b) a second mass of an oxygen sensitive photoluminescent dye in fluid communication with an environmental concentration of oxygen.2011-09-15
20110223679METHOD OF SEEKING AT LEAST ONE ANALYTE IN A MEDIUM LIKELY TO CONTAIN IT - A new method of seeking the presence of an analyte bound to a probe, wherein a periodic geometric pattern (2011-09-15
20110223680Microfluidic Device and Material Manipulating Method Using Same - Microfluidic devices for manipulating relatively dense materials, such as colloidal rod particles, are provided. Microfluidic devices for separating a denser first material from a less-dense second material are provided. Methods of manipulating a relatively dense first material, for example, colloidal rod particles, and separating the first material from a less-dense second material, are provided. Methods of marking samples or sample components with relatively dense materials, are also provided.2011-09-15
20110223681MOBILE WATER ANALYSIS ARRANGEMENT AND METHOD FOR DETERMINING AN ANALYTE IN A WATER SAMPLE - A mobile water analyzing system for determining an analyte in a water sample includes a basic unit and a test element configured to be inserted into the basic unit. The test element includes a sample line with an inlet opening configured to receive the water sample, a measuring section forming a measuring track and configured to allow the determination of an analyte, a pump opening, and a key reagent disposed inside the sample line. The basic unit includes a test element receptacle configured to hold the inserted test element, an analyzer with an analyzer measuring track formed by the measuring section, and a pump actuator cooperatively connected with the pump opening.2011-09-15
20110223682SAMPLE ANALYZER AND REAGENT MANAGEMENT METHOD - A sample analyzer for performing analysis regarding a predetermined measurement item by using a combination of at least a first reagent and a second reagent, the sample analyzer comprising: a reagent container holder configured to hold a first reagent container which contains the first reagent and which includes a first storage medium, and a second reagent container which contains the second reagent and which includes a second storage medium; a writer configured to write information into the first storage medium and the second storage medium; and a controller configured to control the writer to write, into the first storage medium of the first reagent container, identification information for identifying the second reagent container which is paired with the first reagent container is disclosed. A reagent management method is also disclosed.2011-09-15
20110223683AFFINITY SELECTOR BASED RECOGNITION AND QUANTIFICATION SYSTEM AND METHOD FOR MULTIPLE ANALYTES IN A SINGLE ANALYSIS - A multi-dimensional method for simultaneously analyzing multiple analytes within a sample solution, comprising adding affinity selectors to a sample solution containing analytes to be measured, the affinity selectors having an affinity for one or more of the analytes within the sample solution; allowing immune complexes to form between the affinity selectors and the analytes; partially or totally resolving the formed immune complexes from non-analyte substances within the sample solution; dissociating the resolved immune complexes; separating the analytes and the affinity selectors of the dissociated immune complexes from one another by capturing the analytes through a surface adsorption process; transferring the captured analytes to a detection means; and resolving the analytes with the detection means in accordance with their mass-to-charge ratios.2011-09-15
20110223684DETECTION OF SPECIFIC NITRATED MARKERS - Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.2011-09-15
20110223685OXIDIZED APOA1 DETERMINATION BY MASS SPECTROMETRY - Methods are provided for the detection and quantitation of proteins generally and apolipoprotein A-I and oxidized derivatives thereof in particular. Further provided are methods for the assessment of the risk cardiovascular disease in a subject, wherein the assessment is based on the amount of oxidized and unoxidized apolipoprotein A-I in a biological sample obtained from a subject.2011-09-15
20110223686PROTEIN PRODUCTION METHOD, FUSION PROTEIN, AND ANTISERUM - Disclosed are a highly efficient method for production of heterologous proteins performed by utilizing microorganisms, as well as fusion proteins, and an antiserum. The method includes a method for production of a protein (A) in the form of a fusion protein, comprising the steps of (a) preparing a DNA which codes for a fusion protein comprising the peptide chain forming the protein (A) and the C-terminal peptide or its fragment (B) of the Cry proteins produced by 2011-09-15
20110223687METHOD FOR DIAGNOSING NON-SMALL CELL LUNG CANCER - Disclosed are methods for detecting non-small cell lung cancer (NSCLC) using differentially expressed genes KIF11, GHSR1b, NTSR1, and FOXM1. Also disclosed are methods of identifying compounds for treating and preventing NSCLC, based on the interaction between KOC1 and KIF11, or NMU and GHSR1b or NTSR1.2011-09-15
20110223688GRATING-BASED EVANESCENT FIELD MOLECULAR SENSOR USING A THIN SILICON WAVEGUIDE LAYER - A technique for high sensitivity evanescent field molecular sensing employs a detection scheme that simultaneously couples a polarized beam to a single mode of a waveguide, and couples the polarized beam out of the waveguide to specularly reflect the beam by the same grating. Strong interaction with the single (preferably TM) mode is provided by using a silicon on insulator (SOI) wafer having a waveguide thickness chosen between 10-400 nm so that the majority of the mode field strength spans the evanescent field. Well known, robust techniques for producing a grating on the waveguide are provided. Interrogation from a backside of the SOI wafer is taught.2011-09-15
20110223689APPARATUS AND ASSOCIATED METHODS - An apparatus for the selective release of a bound species based on the presence of an analyte, the apparatus comprising: 2011-09-15
20110223690ASSAY - The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent. If analyte is present in the sample, the analyte binds to the labelled species such that the labelled species is unable to bind to the immobilised species but can bind to the immobilised capture reagent via the reporter species, the presence of the analyte thus being determined by the presence of labelled species bound to the immobilised capture reagent via the reporter species.2011-09-15
20110223691RESONANT MAGNETIC DISKS FOR BIOANALYTE DETECTION - Embodiments of the invention relate generally to ferromagnetic microdisks, methods of detecting target bioanalyte using ferromagnetic microdisks, and kits (such as for using in the laboratory setting) containing the reagents necessary to make, and/or use ferromagnetic microdisks for bioanalyte detection, depending on the user's planned application. The methods and products allow the fabrication of ferromagnetic microdisks, and their use in the detection of biological molecules with high sensitivity, little or no signal decay, improved safety, convenience, and lowered cost for use and disposal.2011-09-15
20110223692MICROWAVE INTEGRATED CIRCUIT PACKAGE AND METHOD FOR FORMING SUCH PACKAGE - A method for packaging a semiconductor device. The method includes: providing a dielectric layer over the semiconductor device; determining patterns and placement of material on the dielectric layer to provide a predetermined magnetic or electric effect for the device, such effects being provided on the device from such patterned and placed material solely by electrical or magnetic waves coupled between such material and the device; and forming the material in the determined patterns and placement to provide the predetermined effects.2011-09-15
20110223693HEAT TREATMENT APPARATUS AND METHOD OF PROCESSING SUBSTRATE - There are provided a heat treatment apparatus and a method of processing a substrate, which can control uniformity in thickness of a film formed on a substrate. The heat treatment apparatus includes a processing chamber configured to process a substrate; a heating device configured to heat the substrate from a circumferential side of the substrate accommodated in the processing chamber; a cooling gas channel installed between the heating device and the processing chamber; a cooling device configured to flow a cooling gas into the cooling gas channel; a plurality of cooling gas inhalation passages configured to independently communicate with the cooling gas channel in regions into which the heating device is horizontally divided, and installed between the cooling device and the cooling gas channel; first pressure detectors installed respectively in the plurality of cooling gas inhalation passages; and a control unit configured to control the cooling device based on a first pressure value detected by the first pressure detectors.2011-09-15
20110223694METHOD OF MANUFACTURING SILICON CARBIDE SEMICONDUCTOR DEVICE - A wafer WF is mounted in a substrate holder, and the substrate holder is placed in a film forming furnace. The film forming furnace is evacuated by a vacuum pump through a gas discharge part to remove remaining oxygen as completely as possible. Then, a temperature in the film forming furnace is heated to a range of 800° C. to 950° C. under reduced pressure while an inert gas such as Ar or helium (He) is being introduced through a gas introduction part. When the temperature reaches this temperature range, an inflow of the inert gas is stopped. Vaporized ethanol is introduced as a source gas into the film forming furnace through the gas introduction part, thus forming a graphite film on an entire surface of the wafer WF.2011-09-15
20110223695Electronic assembly with detachable components - The present invention provides systems and methods for assembling an electronic assembly using an anisotropic conducting membrane (ACM) as a component interconnect and a substrate embossed with placement cavities or a positional fixture to facilitate component placement on the substrate in the electronic assembly. The fixture may comprise multiple layers of interconnects to improve routing density for the electronic assembly enclosed in a housing. An alignment chain may be used to monitor positional and contact integrity of the ACM interfaced components in a complex assembly. The systems and methods allow components to be detached for reuse. Interconnection elements or conduction pathways at the components can be used to interconnect a plurality of neighboring substrates over the ACM layers into a stacked electronic assembly.2011-09-15
20110223696UNDERFILL PROCESS FOR FLIP-CHIP LEDS - An underfill technique for LEDs uses compression molding to simultaneously encapsulate an array of flip-chip LED dies mounted on a submount wafer. The molding process causes liquid underfill material (or a softened underfill material) to fill the gap between the LED dies and the submount wafer. The underfill material is then hardened, such as by curing. The cured underfill material over the top and sides of the LED dies is removed using microbead blasting. The exposed growth substrate is then removed from all the LED dies by laser lift-off, and the underfill supports the brittle epitaxial layers of each LED die during the lift-off process. The submount wafer is then singulated. This wafer-level processing of many LEDs simultaneously greatly reduces fabrication time, and a wide variety of materials may be used for the underfill since a wide range of viscosities is tolerable.2011-09-15
20110223697METHOD OF MANUFACTURING FLEXIBLE DISPLAY DEVICE - A method of manufacturing a flexible display device is disclosed. The method includes arranging a first substrate having a plurality of depression units, forming a first plastic film in each of the plurality of depression units, forming a thin film transistor (TFT) on the first plastic film, forming a display device on the TFT, where the display device is configured to be electrically connected to the TFT, encapsulating an upper portion of the display device, cutting the first substrate, and separating the first substrate from the first plastic film.2011-09-15
20110223698CRYSTALLIZATION APPARATUS, CRYSTALLIZATION METHOD, METHOD OF MANUFACTURING THIN FILM TRANSISTOR AND METHOD OF MANUFACTURING ORGANIC LIGHT EMITTING DISPLAY APPARATUS - Provided are a crystallization apparatus and method, which prevent cracks from being generated, a method of manufacturing a thin film transistor (TFT), and a method of manufacturing an organic light emitting display apparatus. The crystallization apparatus includes a chamber for receiving a substrate, a first flash lamp and a second flash lamp, which are disposed facing each other within the chamber, wherein amorphous silicon layers are disposed on a first surface of the substrate facing the first flash lamp and a second surface of the substrate facing the second flash lamp, respectively.2011-09-15
20110223699Wiring Material, Semiconductor Device Provided with a Wiring Using the Wiring Material and Method of Manufacturing Thereof - A semiconductor device having good TFT characteristics is realized. By using a high purity target as a target, using a single gas, argon (Ar), as a sputtering gas, setting the substrate temperature equal to or less than 300° C., and setting the sputtering gas pressure from 1.0 Pa to 3.0 Pa, the film stress of a film is made from −1×102011-09-15
20110223700THIN FILM TRANSISTOR LIQUID CRYSTAL DISPLAY ARRAY SUBSTRATE AND MANUFACTURING METHOD THEREOF - A TFT LCD array substrate and a manufacturing method thereof. The manufacturing method includes the steps of forming a thin film transistor on a substrate to form a gate line and a gate electrode connected with the gate line on the substrate; forming a gate insulating layer and a semiconductor layer on the gate electrode; forming an ohmic contact layer on the semiconductor layer; forming a transparent pixel electrode layer and a source/drain electrode metal layer in sequence on the resultant substrate, wherein the transparent pixel electrode layer is electrically insulated from the gate line and the gate electrode, and the transparent pixel electrode layer forms an ohmic contact with two sides of the semiconductor layer via the ohmic contact layer; and performing masking and etching with a gray tone mask with respect to the resultant substrate to form a transparent pixel electrode, a source/drain electrode and a data line simultaneously.2011-09-15
20110223701GROUP III NITRIDE SEMICONDUCTOR DEVICE, EPITAXIAL SUBSTRATE, AND METHOD OF FABRICATING GROUP III NITRIDE SEMICONDUCTOR DEVICE - A group III nitride semiconductor device having a gallium nitride based semiconductor film with an excellent surface morphology is provided. A group III nitride optical semiconductor device 2011-09-15
20110223702MANUFACTURING METHOD OF MEMS DEVICE, AND SUBSTRATE USED THEREFOR - A method for manufacturing a MEMS device, includes: preparing a substrate provided with a first substrate in which a cavity is formed, and a second substrate that is bonded to a side of the first substrate on which the cavity is formed and includes a slit to delimit a movable portion in a position corresponding to the cavity, the second substrate, including a first surface thereof facing the first substrate, being provided with a thermally-oxidized film selectively formed on the first surface in a position corresponding to the movable portion; forming a first electrode layer on a second surface opposite to the first surface on which the thermally-oxidized film for the movable portion is formed; forming a sacrifice layer on the first electrode layer and the second substrate; forming a second electrode layer on the sacrifice layer; and removing the sacrifice layer and the thermally-oxidized film after the second electrode layer is formed.2011-09-15
20110223703SEALING LAMINATED SHEET FOR ELECTRONIC DEVICE AND ELECTRONIC DEVICE PRODUCTION METHOD USING SAME - The present invention is a sealing laminated sheet for an electronic device in which a first sheet and a second sheet 2011-09-15
20110223704DYE-SENSITIZED SOLAR CELL MANUFACTURING METHOD - A dye-sensitized solar cell manufacturing method of the invention comprises the steps of: preparing a first electrode having an oxide semiconductor layer and a second electrode; forming a first sealing portion by melting and bonding a thermoplastic resin at a first annular section of the first electrode; forming a second sealing portion by melting and bonding a thermoplastic resin at a second annular section of the second electrode; loading a photosensitive dye on the oxide semiconductor layer; forming an electrolyte layer by arranging an electrolyte on the first electrode within the first sealing portion; and forming a sealing portion through bonding the first and second sealing portions, wherein the electrolyte layer is formed after forming the first sealing portion; the sealing portion is formed after loading the dye and forming the electrolyte layer; and the sealing portion is formed through melting the first and second sealing portions, applying pressure.2011-09-15
20110223705PROCESS FOR ASSEMBLING CAMERA MODULE - A process for assembling a camera module is provided. Firstly, a first conductive bump and a second conductive bump are placed on a signal terminal of a substrate and a contact pad of an image sensing chip, respectively. Then, the substrate and the image sensing chip are laminated, so that the first conductive bump and the second conductive bump are combined together and the signal terminal of the substrate and the contact pad of the image sensing chip are electrically connected with each other. Then, an underfill is applied to a region between the substrate and the image sensing chip. Since the two conductive bumps are connected with each other by the assembling process, the quality of the camera module of the present invention is enhanced.2011-09-15
20110223706METHOD OF FORMING A PHOTODETECTOR - A photodetector is formed to have a germanium detector on a waveguide. The germanium detector has a first surface on the waveguide and a second surface that, when exposed to ambient conditions, forms germanium oxide. In a processing platform, an oxygen-free plasma is applied to the second surface. The oxygen-free plasma removes oxygen that is bonded to germanium at the second surface. A cap layer is formed on the second surface prior to removing the germanium detector from the processing platform.2011-09-15
20110223707Backside Illuminated Image Sensor - A backside illuminated image sensor includes a substrate, a backside passivation layer disposed on backside of the substrate, and a transparent conductive layer disposed on the backside passivation layer.2011-09-15
20110223708LOW-COST MULTI-JUNCTION SOLAR CELLS AND METHODS FOR THEIR PRODUCTION - Methods for fabricating solar cells without the need to perform gasification of metallurgical-grade silicon are disclosed. Consequently, the costs and health and environmental hazards involved in fabricating the solar or silicon grade silicon are being avoided. A solar cell structure comprises a metallurgical grade doped silicon substrate and a thin-film structure formed over the substrate to form a p-i-n junction with the substrate. The substrate may be doped p-type, and the thin film structure may be an intrinsic amorphous layer formed over the substrate and an n-type amorphous layer formed over the intrinsic layer.2011-09-15
20110223709METHOD FOR MANUFACTURING THIN-FILM PHOTOELECTRIC CONVERSION DEVICE - A method for manufacturing a thin-film photoelectric conversion device includes forming a first electrode layer, a photoelectric conversion layer having three conductive semiconductor layers laminated thereon, and a second electrode layer sequentially laminated in this order on a translucent insulating substrate, such that adjacent thin-film photoelectric conversion cells are electrically connected in series, isolating a thin-film photoelectric conversion cell into a plurality of thin-film photoelectric conversion cells by forming isolation trenches that reach from the second electrode layer to the first electrode layer, removing a part of sidewalls at an external periphery of the thin-film photoelectric conversion cells positioned at an external peripheral edge of the thin-film photoelectric conversion device, along with the external periphery, and modifying into insulation layers by performing an oxidation process on all of the sidewalls of the isolation trenches of the photoelectric conversion layer and all of the sidewalls at the external periphery.2011-09-15
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