34th week of 2014 patent applcation highlights part 54 |
Patent application number | Title | Published |
20140235420 | CONTROL SYSTEM FOR A DECANTER CENTRIFUGE - A torque sensing device capable of measuring the force exerted by a torque arm on a lever is positioned between the torque arm and the lever. The torque arm is connected to the pinion of a planetary gearbox for rotating the bowl and screw conveyer of a decanter centrifuge at different speeds. The torque sensing device measures the torque between the pinion gear and the planetary gearbox. The sensor can be connected to a controller which can reduce the flow of the liquid/solid mixture to the decanter centrifuge thereby/reducing the torque and avoiding substantial damage to the planetary gearbox. | 2014-08-21 |
20140235421 | CENTRIFUGE, CENTRIFUGE SYSTEM AND METHOD - A centrifuge device displays a workflow diagram during operation. The workflow diagram includes a loading step-indicator, a running step-indicator, and an unloading step-indicator. The loading step-indicator is displayed when the centrifuge device is operating in a loading mode. The running step-indicator is displayed when the centrifuge device is operating in a running mode. The unloading step-indicator is displayed when the centrifuge device is operating in the unloading mode. A centrifuge system includes the centrifuge device and a handheld device operable remote from the centrifuge device, which displays a status of the centrifuge device. Methods of operating a centrifuge device and a centrifuge system are also disclosed. | 2014-08-21 |
20140235422 | CENTRIFUGAL SEPARATOR - A centrifugal separator includes a frame and a rotating part including a spindle and a centrifuge rotor enclosing a separation space. An inlet channel provides fluid communication into the separation space and includes a rotary channel part, a frame channel part, and a first seal at the interface between the rotary and frame channel parts. An outlet channel provides fluid communication out from the separation space and includes a rotary channel part, a frame channel part, and a second seal at the interface between the rotary and frame channel parts. The inlet and outlet channels are arranged concentrically with each other. A forcing device is provided to generate a leak flow through one of the first and second seals in a first direction from the outlet channel to the inlet channel and to counteract leakage in the opposite direction. | 2014-08-21 |
20140235423 | CENTRIFUGE AND DISCHARGE PORT MEMBER OF A CENTRIFUGE FOR POWER REDUCTION - A rotating machine has a bowl that is rotatable about an axis to generate a cylindrical pool of a feed slurry. The bowl has a heavy phase discharge port and a base plate at one longitudinal end of the bowl. There is at least one outlet opening in the base plate and a liquid phase discharge port member positioned over the outlet opening. The liquid phase discharge port member includes at least one open straight channel having a longitudinal axis that extends at an acute angle relative to the base plate. The channel has an extension in the direction of the longitudinal axis of open straight channel. | 2014-08-21 |
20140235424 | Low Dielectric Glass And Fiber Glass - Glass compositions are provided that are useful in a variety of applications including, for example, electronics applications, reinforcement applications, and others. Some embodiments of glass compositions can provide desirable dielectric constants, desirable dissipation factors, and/or desirable mechanical properties while also having desirable fiber forming properties. | 2014-08-21 |
20140235425 | GLASS SUBSTRATE AND METHOD FOR PRODUCING SAME - A glass substrate contains specific contents of SiO | 2014-08-21 |
20140235426 | CERAMIC POWDERS AND METHODS THEREFOR - A ceramic powder and method of forming the ceramic powder capable of being used in coatings to allow components to survive in high temperatures environments, such as the hostile thermal environment of a gas turbine engine. The ceramic powder includes powder particles each having an inner core formed of a first material and an outer region formed of a second material. The inner core has a lower thermal conductivity than the outer region, and the outer region is more erosion resistance relative to the inner core. | 2014-08-21 |
20140235427 | SINTERED ZIRCON MATERIAL FOR FORMING BLOCK - A component includes a body including zircon (ZrSiO | 2014-08-21 |
20140235428 | SUPPORTED BIMETALLIC NANOCOMPOSITE CATALYST AND THE PREPARATION METHOD THEREOF - A highly active supported bimetallic nanocatalyst and its preparation method is disclosed. During the preparation, using an ion exchange or absorption resin bearing basic functional groups as the support of the said catalyst, successively introducing the first metal precursor FeCl | 2014-08-21 |
20140235429 | PROCESS FOR ENHANCING NICKEL TOLERANCE OF HEAVY HYDROCARBON CRACKING CATALYSTS - The invention discloses a process for upgrading feed streams containing residual fractions with high concentrations of metals, more specifically nickel content up to 150 ppm employing acidic catalysts comprising large pore rare earth faujasite zeolite component, pentasil zeolite component and pseudoboehemite containing resid cracking component while the composite is impregnated with lanthanum oxide or aluminium oxide or mixture of both. The hydrocarbon feed stock can be sourced from either petroleum derivatives or from coal, tar or sand. The process results in increased selectivity of propylene in LPG in the range of 39-52%. | 2014-08-21 |
20140235430 | METHOD AND APPARATUS FOR TESTING A CATALYST MATERIAL - A method of ageing a catalyst material includes at least the steps of: (a) heating a gaseous stream; (b) adding a least one pure hydrocarbon gas and an oxygen-containing gas to the heated gaseous stream to provide a combined stream; and (c) passing the combined stream through the catalyst material. The use of at least one pure hydrocarbon gas and an oxygen-containing gas allows maximum re-circulation of the exit stream from the catalyst material for reuse, while maintaining the correct C, H and O proportions being provided in the combined stream to replicate realistic use of the catalyst material. | 2014-08-21 |
20140235431 | EXHAUST GAS-PURIFYING CATALYST - An exhaust gas-purifying catalyst includes a substrate, and a catalytic layer facing the substrate and including a precious metal, alumina, an oxygen storage material, and a sulfate of an alkaline-earth metal having an average particle diameter falling within a range of 0.01 to 0.70 μm, the average particle diameter being obtained by observation using a scanning electron microscope. Another exhaust gas-purifying catalyst includes a substrate, and a catalytic layer formed on the substrate using slurry containing a precious metal, alumina, an oxygen storage material, and a sulfate of an alkaline-earth metal having an average particle diameter falling within a range of 0.01 to 0.70 μm, the average particle diameter being obtained by observation using a scanning electron microscope. | 2014-08-21 |
20140235432 | Transition Metal-Containing Catalysts and Processes for Their Preparation and Use As Oxidation and Dehydrogenation Catalysts - This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols. | 2014-08-21 |
20140235433 | EXHAUST GAS PURIFICATION CATALYST AND METHOD FOR PRODUCING THE SAME - An exhaust gas purification catalyst includes a Rh-containing catalyst layer provided on a base material. The Rh-containing catalyst layer includes Rh-supporting Zr-based composite oxide in which Rh6 is supported on Zr-based composite oxide containing Zr and a rare earth metal except Ce. The Rh-supporting Zr-based composite oxide has been previously subjected to a reduction treatment. | 2014-08-21 |
20140235434 | EXHAUST GAS PURIFICATION CATALYST AND METHOD FOR PRODUCING THE SAME - An exhaust gas purification catalyst includes a Rh-containing catalyst layer provided on a base material. The Rh-containing catalyst layer includes a binder material of Rh-doped CeZr-based composite oxide containing Ce and Zr and doped with Rh. The binder material has been previously subjected to a reduction treatment. | 2014-08-21 |
20140235435 | SILICA SPHERES AND AFFINITY CARRIER - To provide an affinity carrier with a low pressure loss and a large binding capacity even when the linear flow rate of a solution to be made to pass therethrough is high. | 2014-08-21 |
20140235436 | HYDROTHERMAL PERFORMANCE OF CATALYST SUPPORTS - A high surface area catalyst with a mesoporous support structure and a thin conformal coating over the surface of the support structure. The high surface area catalyst support is adapted for carrying out a reaction in a reaction environment where the thin conformal coating protects the support structure within the reaction environment. In various embodiments, the support structure is a mesoporous silica catalytic support and the thin conformal coating comprises a layer of metal oxide resistant to the reaction environment which may be a hydrothermal environment. | 2014-08-21 |
20140235437 | COLOR ACCEPTOR REACTING IN A COLOR-FORMING MANNER TO A PIGMENT PRECURSOR AND HEAT-SENSITIVE RECORDING MATERIAL HAVING SUCH A COLOR ACCEPTOR - A color acceptor for chemical reaction with a dye precursor to form a visually recognizable color. The color acceptor is constructed of lactic acid monomers. Also disclosed is a heat-sensitive recording material with a substrate and a heat-sensitive recording layer, wherein the heat-sensitive recording layer contains at least one dye precursor and at least one color acceptor which react with one another in a color-forming manner when heat is applied, and wherein the color acceptor is constructed of lactic acid monomers. | 2014-08-21 |
20140235438 | MULTI-PURPOSE LIGNIN-CARBOHYDRATE BINDING SYSTEM - The present invention relates to a novel, dual purpose binder formulation or system. The invention also relates to a process of agglomerating dispersed particles or fines into substantially spherical and crush resistant granules. The invention further relates to a method of covering a seed and binding the seed with a material mixture beneficial for seed germination. The invention also relates to an all-in-one seed agglomerated by the dual purpose binder formulation. | 2014-08-21 |
20140235439 | 3,5-DISUBSTITUTED-4,5-DIHYDRO-1,2,4-OXADIAZOLES AND COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS - Provided herein are new 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles that exhibit nematicidal activity and are useful, for example, in compositions and methods for the control of unwanted nematodes. | 2014-08-21 |
20140235440 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO - This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) | 2014-08-21 |
20140235441 | Fungicidal Substituted 1--1H-[1,2,4]triazole Compounds - The present invention relates to substituted 1-{2-cyclyloxy-2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-ethyl}-1H-[1,2,4]triazole compounds of formula I as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound. | 2014-08-21 |
20140235442 | PESTICIDAL COMPOSITION COMPRISING A PYRIDYLETHYLBENZAMIDE DERIVATIVE AND AN INSECTICIDE COMPOUND - A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1000 to 1000/1. | 2014-08-21 |
20140235443 | HERBICIDAL COMPOSITIONS COMPRISING 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)PYRIDINE-2-CARBOXYL- IC ACID OR A DERIVATIVE THEREOF AND PROPYZAMIDE - Herbicidal compositions and methods of controlling undesirable vegetation using a combination of (a) a compound of formula (I): | 2014-08-21 |
20140235444 | SYNERGISTIC SUPRESSION OF GRASS SEEDHEAD PRODUCTION FROM APPLICATIONS OF AMINOCYCLOPYRACHLOR AND METSULFURON - Disclosed herein are herbicidal compositions comprising a synergistically effective amount for preventing or suppressing grass seedhead production of (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) metsulfuron, or an agriculturally acceptable salt or ester thereof. Also disclosed herein are methods of preventing or suppressing grass seedhead production, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent or suppress grass seedhead production (a) aminocyclopyrachlor, or an agriculturally acceptable salt or ester thereof, and (b) metsulfuron, or an agriculturally acceptable salt or ester thereof, wherein (a) and (b) are each added in an amount sufficient to produce a synergistic grass seedhead-suppressant effect. | 2014-08-21 |
20140235445 | PESTICIDE COMPOSITIONS INCLUDING POLYMERIC ADJUVANTS - Pesticidal compositions of improved effectiveness are provided, including a pesticide (e.g., an insecticide or herbicide) together with a copolymer adjuvant or additive selected from the group consisting of acid or salt copolymers containing individual quantities of maleic and itaconic moieties. The compositions of the invention provide multiple-fold increases in effectiveness, as compared with an equal amount of the pesticide in the absence of the copolymer. | 2014-08-21 |
20140235446 | 2,3-DIPHENYL-VALERONITRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES AND PLANT GROWTH REGULATORS - The compounds of the formula (I) | 2014-08-21 |
20140235447 | METHODS FOR INCREASING CROP YIELD - The subject invention is based on unexpected more than additive effect of multiple applications of at least one cyclopropene on crop yield as compared to single applications. Provided are methods of increasing yield of a plant comprising contacting the plant with multiple applications of a cyclopropene. In one aspect, the method comprises (a) contacting the plant with a first composition comprising a cyclopropene; and (b) contacting the plant with a second composition comprising a cyclopropene; thereby increasing the yield of the plant in comparison to a plant not contacted with the first composition and/or the second composition. In another aspect, the method comprises contacting the plant with two or more separate applications of a composition comprising at least one cyclopropene thereby increasing the yield of the plant in comparison to a plant not treated or contacted with two or more separate applications of a composition comprising at least one cyclopropene. | 2014-08-21 |
20140235448 | METHOD AND APPARATUS FOR COMPENSATING FOR DRIFT IN MAGNETIC FIELD STRENGTH IN SUPERCONDUCTING MAGNETS - An MRI system has a cylindrical superconducting magnet assembly contained in a bore tube of a cylindrical vacuum vessel (OVC), and a gradient coil assembly situated within the OVC bore tube. In an imaging region within a bore of the gradient coil assembly, the magnet assembly produces a magnetic field that is subject to drift during operation of the MRI system. Compensating material is located at a radial position between the imaging region and the magnet in a location that will be heated over a range of temperatures during operation of the MRI system. The compensating material is adjustable between two magnetic phases in response to an applied physical characteristic, which is selectively applied thereto so as to change the compensating material from a first magnetization to a second magnetization, and thereby compensate the drift. | 2014-08-21 |
20140235449 | METHOD OF COOLING A SUPERCONDUCTIVE CABLE - A method of cooling at least one superconductive cable is disclosed which is arranged in a cryostat having at least one thermally insulated pipe with a free space surrounded by the pipe, wherein the cable and at least one tubular structure are arranged in the free space, and wherein a cooling agent is conducted through the free space from a feeding point located at one end to a distal end. The cooling agent is conducted through the cryostat and the tubular structure exclusively in one direction of the cable until it reaches its temperature of operation and is discharged to the outside at the distal end. After reaching the temperature of operation, the cooling agent is returned from the distal end of the arrangement through the tubular structure to the feeding point. | 2014-08-21 |
20140235450 | MULTI-TUNABLE SUPERCONDUCTING CIRCUITS - A method of characterizing a tunable superconducting circuit, includes selecting an operating direct current (DC) flux for a first charge island from a plurality of coupled charge islands residing in the tunable superconducting circuit coupled to a first resonator and a second resonator, tuning operating DC flux values for at least two charge islands from the plurality of coupled charge islands, measuring coupling energies of the first resonator and the second resonator and measuring frequencies from each of the plurality of coupled charge islands. | 2014-08-21 |
20140235451 | SUPERCONDUCTING COIL PROTECTION METHOD AND SUPERCONDUCTING MAGNET DEVICE - An object of the present invention is to provide a method for protecting a superconducting coil, which method prevents damage to the superconducting coil caused by a quench or the like, in a new way, without using a voltage (a change in voltage) generated in the superconducting coil. Provided is the method for protecting a superconducting coil made by winding tape-like superconducting wire having a superconducting layer. Power from a power supply is shut off based on the magnitude of a screening field, which is a difference between a measured magnetic field B in a direction of a thickness of the superconducting wire at a predetermined position, and a magnetic field Bcal in the direction of the thickness of the superconducting wire calculated disregarding an effect of screening current. | 2014-08-21 |
20140235452 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2014-08-21 |
20140235453 | GLOBAL TRANSCRIPTION MACHINERY ENGINEERING - The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes. | 2014-08-21 |
20140235454 | MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILES - There is a need or improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. Identified biomarkers can be used to determine and/or monitor the disease state for a subject with an associated lymphoid disorder or autoimmune disease or other condition. In particular, the invention provides a sensitive method for monitoring lymphoid neoplasms that undergo clonal evolutions without the need to development alternative assays for the evolved or mutated clones serving as patient-specific biomarkers. | 2014-08-21 |
20140235455 | USE OF HOXA9 GENE AS A BIOMARKER FOR THE DETECTION OF HEPATOCELLULAR CARCINOMA - A method of detecting hepatocellular carcinoma includes the steps of: detecting a methylation level of a CpG site of HOXA9 gene in a biological sample taken from a suspected subject; and comparing the methylation level to a reference methylation level of a CpG site of HOXA9 gene in another biological sample taken from a normal subject not suffering from hepatocellular carcinoma, wherein when the methylation level is higher than the reference methylation level, the suspected subject is likely to suffer from hepatocellular carcinoma, and wherein each of the biological samples is selected from the group consisting of a blood sample, a serum sample, and a plasma sample. | 2014-08-21 |
20140235456 | Methods and Compositions for Identifying Global Microsatellite Instability and for Characterizing Informative Microsatellite Loci - The disclosure provides methods and systems for assessing microsatellites, for identifying informative microsatellite loci, and for using microsatellite data. Microsatellite information has numerous uses including, for example, to characterize disease risk, to predict responsiveness to therapy, and to non-invasively diagnose subjects. | 2014-08-21 |
20140235457 | SYSTEMS AND METHODS FOR GENETIC AND BIOLOGICAL ANALYSIS - The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices. | 2014-08-21 |
20140235458 | METHODS AND TOOLS FOR THE DIAGNOSIS AND PROGNOSIS OF UROGENITAL CANCERS - The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly urogenital cancers. The microarray can include a plurality of genomic regions represented thereon, the genomic regions corresponding to regions wherein alterations, such as copy number aberrations, at such locations correlate to specific, identifiable cancers, particularly prostate, renal, or bladder tumors. The invention further provides methods of diagnosing certain types of cancers, particularly urogenital cancers, more particularly renal cortical cancers. The methods can comprise analyzing genetic material from a human individual to determine the presence or presence of certain aberrations and using a decision tree to classify the subtype of renal cortical neoplasm present in the sample. | 2014-08-21 |
20140235459 | Genotypes, Alleles and Molecular Markers Associated With Asian Soybean Rust, as Well as Methods, Processes and Uses Thereof - The present invention relates to screening methods for rust resistance or tolerance, in particular, Asian soybean rust (ASR— | 2014-08-21 |
20140235460 | QUANTITATIVE NUCLEASE PROTECTION ASSAY (QNPA) AND SEQUENCING (QNPS) IMPROVEMENTS - The present disclosure provides an improvement to quantitative Nuclease Protection Assay (qNPA) and quantitative Nuclease Protection Sequencing (qNPS) methods. The disclosed methods use nuclease protection probes (NPPs) that include 5′-end and/or 3-end flanking sequences, which provide a universal hybridization and/or amplification sequence. The disclosed methods can be used to sequence or detect target nucleic acid molecules, such as those present in fixed or insoluble samples. | 2014-08-21 |
20140235461 | ALGORITHMS FOR SEQUENCE DETERMINATIONS - The invention provides methods of determining a consensus sequence from multiple raw sequencing reads of a nucleic acid target. The nucleic acid target includes an anchor segment of known sequence and an adjacent segment of unknown sequence. The anchor segment provides a means to assess the quality of a raw target sequencing read. Raw target sequencing reads meeting or exceeding a threshold are assigned to an accepted class. The consensus sequence of the adjacent segment can be determined from raw target sequencing reads in the accepted class. Successive polling steps determine successive consensus nucleobases in a nascent sequence of the adjacent segment. Raw target sequencing reads can be removed or reintroduced from the accepted class depending on their correspondence to the most recently determined consensus nucleobase and/or the nascent sequence. | 2014-08-21 |
20140235462 | METHODS AND COMPOSITIONS FOR NANOSTRUCTURE-BASED NUCLEIC ACID SEQUENCING - Provided herein are nanostructure-based sequencing methods and systems. | 2014-08-21 |
20140235463 | METHODS AND APPARATUS FOR MEASURING ANALYTES - Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2014-08-21 |
20140235464 | DETECTION AND QUANTIFICATION OF BIOMOLECULES USING MASS SPECTROMETRY - The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry. This process is easily incorporated into a polymerase chain reaction (PCR) amplification assay. The method also includes embodiments directed to quantitative analysis of target nucleic acids. | 2014-08-21 |
20140235465 | METHOD OF USING NEUTRILIZED DNA (N-DNA) AS SURFACE PROBE FOR HIGH THROUGHPUT DETECTION PLATFORM - A method of using Neutrilized DNA (N-DNA) as a surface probe for a high throughput detection platform is disclosed. FET and SPRi are used as high throughput detection platforms to demonstrate that the N-DNA surface probe produces good results and enhances detection sensitivity. The N-DNA modifies the charged oxygen ions (O | 2014-08-21 |
20140235466 | Tumor biomarkers for pancreatic marker - This invention pertains generally to the fields of molecular biology and medical diagnosis. More particularly this invention provides novel biomarkers for the detection of pancreatic cancer comprising at least one messenger RNA and/or up-regulated peptide in pancreatic cancer. The present invention provides biomarkers capable of discriminating between non-neoplastic pancreatic tissues and ductal adenocarcinoma tissues and can be correlated with a probable diagnosis of pancreatic cancer as well as assessing the efficacy of ongoing therapies for this disease. | 2014-08-21 |
20140235467 | Protease-Resistant Systems for Polypeptide Display and Methods of Making and Using Thereof - The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics. | 2014-08-21 |
20140235468 | HIGH THROUGHPUT MINIATURIZED ASSAY SYSTEM AND METHODS - The present invention provides an apparatus for conducting biological assays which employs “virtual wells” in lieu of the physical wells of conventional array plates. Also provided are methods of processing a sample and/or culturing cells using the apparatus and systems described herein. In some embodiments, the apparatus includes a first structure having a sheet layer with a plurality of discrete through holes; and a second structure coupled to the first structure, the second structure including a base layer. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure, and a second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the base layer of the second structure adjacent the first surface of the base layer. | 2014-08-21 |
20140235469 | MIRNA BIOMARKERS OF PROSTATE DISEASE - This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer. | 2014-08-21 |
20140235470 | MULTIPLEX NUCLEIC ACID DETECTION METHODS - Methods for multiplex ligation-dependent probe amplification include (a) providing a sample tissue to query different target nucleic acids, (b) providing different probe sets for each of the target nucleic acids, each probe set including a first locus specific probe having a first adapter sequence and a first target specific portion and a second locus specific probe having a second adapter sequence, and a second target specific portion adjacent to the first target specific portion, (c) hybridizing the probe sets to the target sequences to form hybridization complexes, (d) ligating the hybridization complexes to form ligated probes, (e) amplifying the ligated probes to form amplicons, the amplifying step being carried out with a first universal primer including a region complementary to the first adapter sequence and a second universal primer including a region complementary to the second adapter sequence, and (f) detecting the amplicons in a detection system by sequencing each of the amplicons. | 2014-08-21 |
20140235471 | Global Proteomic Screening Of Random Bead Arrays Using Mass Spectrometry Imaging - Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing. | 2014-08-21 |
20140235472 | METHODS AND COMPOSITIONS FOR THE DETECTION OF BALANCED RECIPROCAL TRANSLOCATIONS/REARRANGEMENTS - Disclosed are methods and compositions related to the detection of balanced reciprocal translocations/rearrangements and determination of the location of said balanced reciprocal translocations/rearrangements. Also disclosed are methods and compositions relating to the diagnosis of a disease or condition associated with uncontrolled cellular proliferation by the detection of balanced reciprocal translocation/rearrangement. Additionally, also disclosed are kits for the detection of balanced reciprocal translocations/rearrangements. | 2014-08-21 |
20140235473 | Diagnosis and/or Prognosis of Parkinson's Disease Dementia - The present Invention provides a method for diagnosing and/or prognosing Parkinson's disease dementia (PDD) comprising the step of detecting O-glycosylation. in a protein comprising a Ser/Thr motive, in particular Serpin A1, and/or the level of sialic acid on a protein comprising a Ser/Thr motive, in particular Serpin A1. Further, the present invention relates to a molecule for detecting O-linked glycomoieties in a protein comprising a Ser/Thr motive, in particular Serpin A1, and/or glycosylated i so forms of a Ser/Thr motive comprising protein, in particular Serpin A1, for use in the diagnosis and/or prognosis of Parkinson's disease dementia (PDD), Furthermore, the present invention relates to means for diagnosing and/or prognosing Parkinson's disease dementia (PDD) and a kit for diagnosing and/or prognosing Parkinson's disease dementia (PDD). | 2014-08-21 |
20140235474 | METHODS AND PROCESSES FOR NON INVASIVE ASSESSMENT OF A GENETIC VARIATION - Provided in part herein are methods and processes that can be used for non-invasive assessment of a genetic variation which can lead to diagnosis of a particular medical condition or conditions. Such methods and processes can, for example, identify dissimilarities or similarities for one or more features between a subject data set and a reference data set, generate a multidimensional matrix, reduce the matrix into a representation and classify the representation into one or more groups. Methods and processes described herein are applicable to data in biotechnology and other fields. | 2014-08-21 |
20140235475 | TH17 DIFFERENTIATION MARKERS FOR ACNE AND USES THEREOF - A method is described for using ROR gamma t or ROR alpha to diagnose acne and/or to screen inhibitors of Th17 differentiation. Specifically described are methods of inhibiting ROR gamma t or ROR alpha and use of the screened inhibitors in acne treatment. | 2014-08-21 |
20140235476 | MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS FOR IDENTIFYING VARIANTS OF SAME - Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., DVD-Fab or DVD-Ig molecules) and the use of these libraries for the screening of multivalent binding proteins using cell surface display technology (e.g., yeast display). | 2014-08-21 |
20140235477 | Measurement and Monitoring of Cell Clonality - Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion. | 2014-08-21 |
20140235478 | Measurement and Comparison of Immune Diversity by High-Throughput Sequencing - High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects. | 2014-08-21 |
20140235479 | SIGNATURES AND PCDETERMINANTS ASSOCIATED WITH PROSTATE CANCER AND METHODS OF USE THEREOF - The present invention provides methods of detecting cancer using biomarkers. | 2014-08-21 |
20140235480 | Ultra-sensitive Detection of Analytes - The present invention provides devices and methods for ultra-sensitive detection of analytes of interest in a rapid and convenient manner. A portable handheld device having replaceable cartridges adaptable for detection of a wide array of analytes (e.g., biological, environmental, and the like) is provided. Sample wells containing bound capture antibodies are provided with microelectrical circuits across each of the sample wells such that there is a nanoscale gap which prevents passage of electrical current. A sample potentially containing the analyte of interest is pumped into a sample well containing bound capture antibodies directed to an first epitope of the analyte of interest. After removal of unbound sample, a metal-labeled antibody directed to a second epitope of the analyte of interest thereby, if the analyte of interest was present in the sample, a metal-labeled antibody-analyte-capture antibody complex remains bound to the sample well. Passage of electrical current across the nanoscale gap (as indicated by a change in electrical resistance, capacitance, impedance and/or conductance, as well as combinations thereof, as compared to the blank control well) thereby reveals the presence of the metal-labeled antibody-analyte-capture antibody complex and, thus, the presence of the analyte of interest in the sample. | 2014-08-21 |
20140235481 | CANCER BIOMARKER AND METHODS OF USE THEREOF - Certain embodiments of the present invention provide methods for identifying subjects that have, or are at risk for developing, cancer. Certain embodiments of the present invention provide methods for determining the effectiveness of cancer treatments. | 2014-08-21 |
20140235482 | IMMUNOGLOBULIN FC POLYPEPTIDES - Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain. | 2014-08-21 |
20140235483 | PARALLEL DETERMINATION OF COMPETITIVE BINDING AND TARGET SPECIFICITY OF A BINDING COMPOUND LIBRARY BY HIGH-THROUGHPUT DNA SEQUENCING - The invention is directed to a method for analyzing the competitive binding and target (or ligand) specificity of large numbers of candidate binding compounds with respect to a predetermined reference compound. That is, the invention provides a method for essentially conducting a massively parallel ELISA on each member of an entire library of candidate binding compounds at the same time. Instead of determining binding characteristics from a series of colorimetric or fluorometric readouts, such characteristics are determined from a series of frequencies of bound and unbound library members which, in turn, are determined by high-throughput sequencing of their encoding nucleic acids. In one aspect, predetermined reference compounds are proteins and candidate binding compounds are members of a mutant library based on or related to, the predetermined reference compound. | 2014-08-21 |
20140235484 | METHODS FOR DETECTION AND DIFFERENTIATION OF ORIGIN OF VIRAL DNA - The invention disclosed herein provides methods for identifying the origin of viral DNA in a sample by detecting the methylation state of at least one CpG site on a target site of the genome of a virus of interest, and determining whether the origin of the viral DNA is from a cell, such as a tumor cell, or a virion, wherein when the methylation state is positive for methylation, the viral DNA is from a cell, and wherein when the methylation state is negative for methylation, the viral DNA is from a virion. Use of these methods for diagnosis or monitoring, and/or treatment of a subject infected with a virus known to cause cancer and related disease are also provided. | 2014-08-21 |
20140235485 | Methods And Devices For Amplification Of Nucleic Acid - The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array. | 2014-08-21 |
20140235486 | Methods and Compositions for the Treatment and Diagnosis of Breast Cancer - The invention provides for methods of diagnosis, prognosis and treatment of cancer including, but not limited to, breast cancer. | 2014-08-21 |
20140235487 | ORAL CANCER RISK SCORING - Neural net method of computing oral cancer risk based on inputs such as age, gender, smoking status, morphological characteristics of sampled cells, and levels of biomarkers in samples cells. | 2014-08-21 |
20140235488 | MICRORNA PATTERNS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MELANOMA - The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof. | 2014-08-21 |
20140235489 | Integrated Membrane Sensor - An integrated microelectronic sensor is provided in a disposable flow membrane sensing device. The integrated sensors detect electromagnetic effect labels in flow detection zones above the sensor in the membrane. The labels are small particles that give off a detectable electromagnetic signal. They are commonly used for isolating and quantifying biochemical targets of interest. The sensors are fabricated using planar integrated circuit technologies. Sensors can detect labels of several types including magnetic, electric, and photonic. These types all have in common the fact that the sensor detects the label at a distance. Magnetoresistive sensors for detecting magnetic labels, and photodiodes for detecting photonic labels are described. | 2014-08-21 |
20140235490 | METHODS FOR DETECTION OF BOTULINUM NEUROTOXIN - Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. Also provided herein are novel peptides that can be specifically cleaved by BoNT and novel peptides that are resistant to cleavage by BoNT. The combination of these cleavable and control peptides can be used for implementation of an exemplary ALISSA used to specifically detect BoNT enzymatic activity. Furthermore, the ALISSA as described herein may also be used in a column based format for use in a high-throughput system for testing large quantities of samples. | 2014-08-21 |
20140235491 | METHOD OF APPLYING ETFB TO ABNORMAL PROLIFERATION OF CELL, AND ABNORMAL PROLIFERATION INHIBITOR - Provided is a method for identifying and suppressing abnormal growth of fibroblasts at an early stage. Provided is a method for identifying the growth state of fibroblasts using as an index the level of expression of ETFB (electron transfer flavoprotein beta subunit), comprising: judging, in cases where the level of expression of ETFB is high, that there is a high probability that fibroblasts are abnormally growing; and judging, in cases where the level of expression of ETFB is low, that there is a high probability that fibroblasts are normally growing. Further, by inhibition of ETFB, abnormal growth of fibroblasts can be suppressed. | 2014-08-21 |
20140235492 | METHODS FOR PREPARING SINGLE DOMAIN ANTIBODY MICROARRAYS - The present invention relates to a method for preparing sd Ab microarray comprising the step consisting of: —i) providing a host cell capable of expressing a biotinylation enzyme —ii) transforming said host cell with a nucleic acid encoding for a fusion protein wherein a single domain antibody is fused at its carboxy terminal end to a biotinylation peptide —iii) culturing said host cell in presence of biotin in such a way that said fusion protein and biotinylation enzyme are expressed, resulting in biotinylation of said fusion protein —iv) lysing said host cell as cultured at step iii) —v) spotting the lysate obtained at step iv) on a solid sup port coated with an agent selected from the group consisting of avidin, streptavidin and/or any art known derivative of these agents A further object of the invention relates to a sd Ab microarray obtainable by the method of the invention. | 2014-08-21 |
20140235493 | MULTIMODE PLATFORM FOR DETECTION OF COMPOUNDS - A muitimode gas sensor platform ( | 2014-08-21 |
20140235494 | Methods, Kits and Computer Program Products using Hepatocellular Carcinoma (HCC) Biomarkers - Methods of determining the presence or risk of liver disease or other diseases in a subject include measuring a level of a saccharide selected from N-acetylneuraminic acid, N-acetylglucosamine, N-acetylgalactosamine, or a combination thereof on one or more glycosylated proteins and the total amount of alpha-fetoprotein in a biological sample from the subject. Glycosylated proteins include but are not limited to vascular endothelial growth factor, lymphatic vessel endothelial hyaluronan receptor, E-cadherin, alpha 1 acid glycoprotein, glypican-3, galectin-3, and any combination thereof. The presence or risk of disease in the subject is determined responsive to a value based on the level of glycosylation and amount of alpha-fetoprotein. | 2014-08-21 |
20140235495 | CELL RESPONSE ASSAY FOR CANCER AND METHODS OF PRODUCING AND USING SAME - A cell response assay for cancer is provided. In the assay, the levels of a cancer cell type biomarker, a chemo resistance biomarker and a metastatic potential biomarker are simultaneously measured in a biological sample. | 2014-08-21 |
20140235496 | STIMULUS-ELICITED GENOMIC PROFILE MARKERS OF A NEURODEGENERATIVE CONDITION - The present disclosure is directed to methods of diagnosing a neurodegenerative condition, such as Alzheimer's disease, comprising contacting a cell sample from a subject with at least one stimulus, such as a protein and/or polysaccharide mixture, a protein kinase C activator, an Aβ oligomer, an agent, and combinations thereof; and detecting the expression of at least one gene in the cell sample. Methods may further comprise comparing the expression of the at least one gene in the cell sample to the expression of the same at least one gene in control cells; and determining whether the subject has the neurodegenerative condition (e.g., Alzheimer's disease), wherein a change in the expression of the at least one gene in the cell sample compared to the expression of the same at least one gene in the control cells indicates the subject has the neurodegenerative condition (e.g., Alzheimer's disease). | 2014-08-21 |
20140235497 | Identification of Antigen-Specific Adaptive Immune Responses Using ARM-PCR and High-Throughput Sequencing - Disclosed is a method for correlating at least one amino acid sequence from an antibody isolated from human or animal blood with at least one DNA sequence corresponding to the antibody in the immunorepertoire of the human or animal. The method also provides a means for pairing heavy and light chains to produce synthesized monoclonal antibodies. | 2014-08-21 |
20140235498 | ENHANCED THROUGHPUT MINERAL COATINGS FOR OPTIMIZATION OF STEM CELL BEHAVIOR - Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform. | 2014-08-21 |
20140235499 | ASSAY FOR INHIBITORS OF CIP/KIP PROTEIN DEGRADATION - An assay and system compatible with high throughput screening (HTS) that is capable of identifying inhibitors, such as small-molecule inhibitors, of the degradation of the Cdk inhibitor p21, are described. The assay is based on the use of fusion protein comprising (i) a p2 polypeptide; and (i) a reporter protein linked to the C-terminal of said p21 polypeptide, wherein the fusion protein has a half-life that is similar to that of the p21 polypeptide. Inhibitors identified by this assay may be useful to inhibit the proliferation of tumor cells, and thus for the treatment of cancers. | 2014-08-21 |
20140235500 | HIGH THROUGHPUT INSTRUMENTATION TO SCREEN CELLS AND PARTICLES BASED ON THEIR MECHANICAL PROPERTIES - A system for the high-throughput screening of mechanical properties of cells and/or particles is provided. In certain embodiments the system comprises a first structure comprising a plurality of sample receiving wells; a second structure comprising a plurality of exit ports; a porous structure disposed between said plurality of sample receiving wells and said plurality of exit ports and in communication with said plurality of sample receiving wells and in communication with said plurality of exit ports, and said first structure, said second structure and said porous structure are sealed or configured such that when sufficient pressure is applied to sample receiving wells in said first structure said cells or particles migrate through the porous structure into said exit ports, and wherein the mean or the median pore size of said porous structure is smaller than the mean or median cross-section of a cell or particle that is to be screened. | 2014-08-21 |
20140235501 | Enzymatic Biosensing Systems - Biosensors and methods of producing biosensors for use in detecting one or more analytes in a solution are disclosed herein. | 2014-08-21 |
20140235502 | METHOD FOR SCREENING AND QUANTIFYING ISOPRENE BIOSYNTHESIS ENZYME ACTIVITY - A method of performing high-throughput screening of various enzymatic activities with high sensitivity using artificial genetic circuits is provided. Particularly, the invention is screening and quantifying the activity of isoprene biosynthesis enzymes using an artificial genetic circuit capable of sensing isoprene. The artificial genetic circuit comprises an isoprene-sensing transcriptional regulator which recognizes isoprene, at least one reporter gene, a isoprene-sensing transcriptional regulator binding region and promoters for genes encoding isoprene-sensing transcriptional regulators and reporter proteins. | 2014-08-21 |
20140235503 | PREDICTION METHOD OF GLOMERULAR FILTRATION RATE FROM URINE SAMPLES AFTER KIDNEY TRANSPLANTATION - Disclosed is a prediction method of glomerular filtration rate (GFR) from urine samples after kidney transplantation to provide an information needed for predict renal function after the transplantation, more particularly to a prediction method of glomerular filtration rate (GFR) from urine samples after kidney transplantation, which comprises detecting metabolic profiles of five biomarkers, 5a-androst-3-en-17-one (AS), glycocholic acid (GC), sphingosine (SG), tryptophan (TR) and histidine (HT), from urine samples of patients. Glomerular filtration rate (GFR) after kidney transplantation can be predicted more rapidly and precisely to provide an information needed for predict renal function after the transplantation by using five metabolites as biomarkers. The method provides more specific, sensitive, and reliable biomarkers that monitor clinical outcomes and adverse renal events after kidney transplantation, such as rejection, drug toxicity, delayed graft function, and infection. | 2014-08-21 |
20140235504 | ANALYTIC METHOD AND DEVICE WITH A MOVABLE PLUNGER - A method and a device for analyzing a liquid is provided, in which the liquid is distributed to a plurality of containers, and which enables the rapid and inexpensive performing of a multitude of analyses in liquids, in particular DNA analyses, in micro-arrays. The liquid is supplied to a transparent analytical plate which includes a matrix with a plurality of at least unilaterally closed receptacle chambers arranged adjacent to each other. Axially-displaceable plungers are moved towards walls of the receptacle chambers and the analytical plates are transported towards the plungers using a transport apparatus. The liquid can be distributed into the receptacle chambers using mobile elements of the analytical plate, and the elements may be moved by the plungers. At least one axially displaceable plunger may be heated to a preset temperature value and impart this temperature to the accommodating chamber. | 2014-08-21 |
20140235505 | RNA ARRAY COMPOSITIONS AND METHODS - Described herein are RNA arrays, and compositions and methods for generating RNA arrays, particularly high density RNA arrays. The disclosed methods for generating RNA arrays utilize template DNA arrays and RNA polymerase to generate RNA arrays. In some embodiments, the disclosed methods use an RNA polymerase and modified ribonucleosides to generate modified RNA arrays for various applications, e.g. RNA arrays having higher nuclease resistance, more conformationally stable RNA arrays, and higher binding affinity RNA aptamer arrays. In some embodiments, the disclosed methods are used to generate RNA bead arrays. | 2014-08-21 |
20140235506 | POLYNUCLEOTIDE BARCODE GENERATION - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides. | 2014-08-21 |
20140235507 | Protein Chips for High Throughput Screening of Protein Activity - The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates. | 2014-08-21 |
20140235508 | NUCLEIC ACID LINKER - A nucleic acid linker is for producing a complex of mRNA and a protein encoded by that mRNA, comprising one 3′-terminal region and two branched 5′-terminal regions, wherein the 3′-terminal region comprises a single-stranded polynucleotide segment able to hybridize with the sequence on the 3′-terminal side of the mRNA, and an arm segment that branches off from the single-stranded polynucleotide segment and has a linking segment with the protein on the terminal thereof, and one of the two 5′-terminal regions has a binding site with the 3′-terminal of the mRNA. | 2014-08-21 |
20140235509 | TEMPLATE DIRECTED SPLIT AND MIX SYNTHESIS OF SMALL MOLECULE LIBRARIES - The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added step c). | 2014-08-21 |
20140235510 | MICROFLUIDIC INTERFACE FOR HIGHLY PARALLEL ADDRESSING OF SENSING ARRAYS - Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on, a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time. | 2014-08-21 |
20140235511 | MOLECULAR PROFILING OF TUMORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | 2014-08-21 |
20140235512 | LOW VOLATILE PHOSPHOROUS GELLING AGENT - Liquid hydrocarbons are gelled by the introduction of a phosphate ester and a crosslinking agent for use in oil recovery. Generally a proppant, delayed gel breaker and other modifiers are added to the gelled hydrocarbon to improve the oil recovery process. The phosphate ester used in this method and composition for oil recovery has low volatility and good stability during hydrocarbon distillation resulting in improved distillation efficiency in a refinery. | 2014-08-21 |
20140235513 | COATING INCLUDING INORGANIC FULLERENE-LIKE PARTICLES AND INORGANIC TUBULAR-LIKE PARTICLES - In one embodiment, a coating is provided that includes a deposition surface, and a coating on the deposition surface. The coating may include particles of a metal chalcogenide comprising a fullerene-like geometry, a tubular-like geometry or a combination of fullerene-like geometries and tubular-like geometries. The metal chalcogenide composition has a molecular formula of MX | 2014-08-21 |
20140235514 | LUBRICATING COATING COMPOSITION AND ATTACHMENT COMPONENT FOR INTERNAL COMBUSTION ENGINE - A solid coating film ( | 2014-08-21 |
20140235515 | LUBRICATING A TRIBOLOGICAL SYSTEM - A method and gas lubricant are provided for lubricating a tribological system and include providing gaseous carbon dioxide, and bringing the gaseous carbon dioxide into contact with regions of the tribological system to be lubricated. An inert gas may also contact the regions to reduce oxidation. Nitrogen may be used as the inert gas. | 2014-08-21 |
20140235516 | LUBRICANT COMPOSITION FOR MARINE ENGINE - A lubricant composition for 4-stroke or 2-stroke marine engine includes at least one lubricant base oil for marine engine, at least one olefin copolymer, at least one hydrogenated styrene-isoprene copolymer, at least one glycerol ester and at least one detergent, whose use promotes fuel economy and has good properties regarding engine cleanliness, in particular crankcase cleanliness. | 2014-08-21 |
20140235517 | ESTERS FOR USE AS A BASE STOCK AND IN LUBRICANT APPLICATIONS - This invention relates to base ester compounds and complex ester compounds that can be used as a base stock for lubricant applications or a base stock blend component for use in a finished lubricant or for particular applications, and methods of making the same. The base ester compounds and complex esters described herein comprise dimer and/or trimer esters, and their respective branched derivatives. | 2014-08-21 |
20140235518 | AQUEOUS LIQUIDS CONTAINING AN ORGANIC COMPOUND AND AN N-(2-HYDROXYALKYL) SUBSTITUTED N-ALKYLAMINE - Aqueous liquids containing an organic compound and an N-(2-hydroxyalkyl) substituted N-alkylamine, which can be used in emulsion lubricants, emulsion coolants and metalworking fluids resulting in excellent biostability, emulsion stability and overall performance. | 2014-08-21 |
20140235519 | 4,8-DIMETHYL-4,9-DECADIENENITRILE - It is intended to provide a compound and a fragrance composition containing the compound, wherein the compound is useful as a fragrance, has floral and green odors in addition to a strong muguet odor, is stable in an aqueous vehicle, and can be blended with another fragrance to have enhanced freshness and diffusibility. It also is intended to provide 4,8-dimethyl-4,9-decadienenitrile and a fragrance composition containing 4,8-dimethyl-4,9-decadienenitrile. | 2014-08-21 |