32nd week of 2014 patent applcation highlights part 60 |
Patent application number | Title | Published |
20140221586 | Methods for Stereoselective Coordinative Chain Transfer Polymerization of Olefins - The present invention provides a method of producing a polyolefin composition comprising contacting a binuclear metallocene pre-catalyst and a co-catalyst, adding a excess of a metal alkyl, then adding a first olefin monomer. The method allows for the production of polyolefins with a highly stereoregular stereochemical micrsostructure through living coordination polymerization in which rapid reversible chain transfer between a racemic mixture of a chiral active transition metal propagating center and multiple equivalents of inert main group metal alkyl is competitive with chain-growth propagation at the active center. By virtue of the slower rate of chain-transfer relative to propagation that can be achieved with a binuclear catalyst relative to the corresponding mononuclear catalyst, the present invention provides a work-around solution to the intrinsic limitation on product volume imposed by a traditional living polymerization, as well as a work-around solution to the stereochemically random microstructure that is normally obtained as the result of rapid and reversible chain-transfer between two populations of chiral active propagating centers, of opposite absolute configuration, when a racemic mixture of the pre-catalyst is employed. In essence, the field of invention is defined as stereoselective living coordinative chain-transfer polymerization. | 2014-08-07 |
20140221587 | Process for Controlling Molecular Weight of Polyolefins Prepared Using Pyridyl Diamide Catalyst Systems - Pyridyldiamido transition metal complexes are disclosed for use in alkene polymerization to produce polyolefins. | 2014-08-07 |
20140221588 | PROCESS FOR SYNTHESIS OF ETHYLENE POLYMERS - The present invention relates to a non-cryogenic process for the large scale synthesis of disentangled ultra high molecular weight polyethylene (DUHMWPE) polymers. The process comprises of the following steps:
| 2014-08-07 |
20140221589 | Polymerizable Fluoromonomer, Fluoropolymer, Resist Material, and Method of Pattern Formation - Disclosed is a polymerizable fluoromonomer represented by the following general formula (1). In the formula, R | 2014-08-07 |
20140221590 | METHOD OF PURIFYING CONJUGATED POLYMERS - A method of first dissolving a conjugated polymer in a fluid followed by adding an agent to the fluid and evaporating the fluid to produce a solid sample. The solid sample is then ground to produce a fragmented solid sample. This is followed by performing solvent extraction on the fragmented solid sample at elevated temperature and pressure to produce a purified conjugated polymer in a solvent. | 2014-08-07 |
20140221591 | COPOLYMERS FOR NEAR-INFRARED RADIATION-SENSITIVE COATING COMPOSITIONS FOR POSITIVE-WORKING THERMAL LITHOGRAPHIC PRINTING PLATES - There is provided a copolymer having the general structure below, wherein a, b, and d are molar ratios varying between about 0.01 and about 0.90 and c is a molar ratio varying between about 0.01 and about 0.90; A1 represents monomer units comprising a cyano-containing pendant group in which the cyano is not directly attached to the backbone of the copolymer; A2 represents monomer units comprising two or more hydrogen bonding sites; A3 represents monomer units that increase solubility in organic solvents; and A4 represents monomer units that increase solubility in aqueous alkaline solutions. There is also provided a near-infrared radiation-sensitive coating composition comprising this copolymer as well as a positive-working thermal lithographic printing plate comprising a near-infrared radiation-sensitive coating comprising this copolymer, a method of producing such a printing plate, and finally a method of printing using such a printing plate. Formula (I). | 2014-08-07 |
20140221592 | OXO-NITROGENATED COMPLEX OF LANTHANIDES, CATALYTIC SYSTEM COMPRISING SAID OXO-NITROGENATED COMPLEX AND PROCESS FOR THE (CO)POLYMERIZATION OF CONJUGATED DIENES - A bis-imine pyridine complex of lanthanides having general formula (I). Said bis-imine pyridine complex of lanthanides having general formula (I) can be advantageously used in a catalytic system for the (co)polymerization of conjugated dienes. | 2014-08-07 |
20140221593 | Zinc Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts - A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to form a gum, gel, rubber, or resin. | 2014-08-07 |
20140221594 | Polyurethanes Made Using Mixtures of Tertiary Amine Compounds and Lewis Acids as Catalysts - Polyisocyanate-based polymers are formed by curing a reaction mixture containing at least one polyisocyanate and at least one isocyanate-reactive compound having at least two isocyanate-reactive groups in the presence of a tertiary amine catalyst having a molecular weight of up to 300 and from 0.01 to 1.0 mole per mole of the tertiary amine compound(s) of a non-protic, non-catalytic, metal-containing Lewis acid. | 2014-08-07 |
20140221595 | HIGH PURITY DIPHENYL SULFONE, PREPARATION AND USE THEREOF FOR THE PREPARATION OF A POLY(ARYLETHERKETONE) - The presence of certain impurities in diphenyl sulfone have a deleterious effect on the properties of the poly(aryletherketone)s produced therein, including one or more of color, melt stability, molecular weight, crystallinity, etc. and here identify those impurities and provide processes for the recovery of the diphenyl sulfone. | 2014-08-07 |
20140221596 | PROCESS FOR PREPARING POLYSULFONE - The present invention relates to a process for preparing polysulfone, comprising reacting bisphenol monomers with a salt forming agent to form bisphenolate, followed by subjecting the bisphenolate and 4,4′-dihalodiphenyl sulfone to polycondensation to give polysulfone, characterized in that the reaction for forming bisphenolate and the polycondensation are performed in the presence of a composite ionic liquid as the solvent, the composite ionic liquid containing zwitterionic liquid of formula (I) and/or (II) as component A and ionic liquid of formula (III) and/or (IV) as component B, wherein variables are respectively defined in the description of the present invention. The process of the present invention enables a shortened preparation period of polysulfone, particularly a shortened reaction time (including the time of water removal) of the salt forming stage; in addition, the polysulfone thus prepared has an improved molecular weight which is much higher. | 2014-08-07 |
20140221597 | LIGHT-EMITTING ORGANIC COMPOUND AND EL DISPLAY DEVICE UTILIZING THE SAME - By repeating a purification process of a light-emitting organic compound several times, a thin film made of the light-emitting organic compound to be used in an EL display device contains ionic impurities at the concentration of 0.1 ppm or lower and has a volume resistivity in the range of 3×10 | 2014-08-07 |
20140221598 | BIODEGRADABLE POLYESTER - A biodegradable polyester is provided. The biodegradable polyester is composed of a poly(terephthalate-di-(ε-caprolactone) unit, a poly(terephthalate-butylene-terephthalate) unit, a poly(terephthalate-butylene-ε-caprolactone) unit, a poly(ε-caprolactone-butylene-ε-caprolactone) unit, and a poly(tri(ε-caprolactone) unit. | 2014-08-07 |
20140221599 | MOLDED BODY FOR DENTAL USE - Provided is a molded body for dental use, said molded body being made from a polyester resin which as a material for esthetic dentures exhibits excellent fracture resistance and moderate bendability, and which ensures excellent polishability during denture fabrication, and has an alkali resistance which prevents a denture from fracturing due to denture cleaning. This molded body for dental use is made from a polyester resin which is composed of a dicarboxylic acid component containing a terephthalic acid residue, and a glycol component containing a 2,2,4,4-tetramethyl-1,3-cyclobutanediol residue and a 1,4-cyclohexanedimethanol residue, wherein the proportions of the terephthalic acid residue, 2,2,4,4-tetramethyl-1,3-cyclobutanediol residue and 1,4-cyclohexanedimethanol residue in the polyester resin are 30 to 70 mol %, 5 to 25 mol %, and 25 to 50 mol %, respectively. | 2014-08-07 |
20140221600 | BI-AXIALLY STRETCHED PRODUCT - This invention relates to a biaxially stretched product comprising a copolyamide comprising monomeric units of: aliphatic non-cyclic diamines X and aliphatic non-cyclic dicarboxylic acids Y or aliphatic non-cyclic α,ω-amino acids Z, and diamines M and diacids N in an amount between 0.1 to 2 wt % based on the total amount of copolyamide, and in which M and N are cyclic, and wherein the product has been stretched at a temperature of between the glass transition temperature (Tg) and the melting temperature (Tm). A method of preparation is claimed, as well as a multilayer film comprising the biaxially stretched product. | 2014-08-07 |
20140221601 | AMINE/THIOL CURING OF BENZOXAZINES - Novel oligomers and polymers derived from the reaction of benzoxazine compounds with a mixture of thiol compounds and amine compounds are disclosed. The compositions are useful in coating, sealants, adhesive and many other applications. | 2014-08-07 |
20140221602 | METHOD FOR ACTIVATING DOUBLE METAL CYANIDE CATALYSTS FOR THE PRODUCTION OF POLYETHER CARBONATE POLYOLS - The present invention relates to a process for the activation of double metal cyanide (DMC) catalysts with heterocumulenes for the preparation of polyether carbonate polyols by catalytic copolymerization of carbon dioxide (CO | 2014-08-07 |
20140221603 | INITIATOR - An initiator for cationic polymerization comprises a salt of a protic acid as well as a protic add. The molar ratio of protic acid to salt is in the range from 1:0.01 to 1:2000. The initiator is used for example for cationic homo- or copolymerization of trioxane, and permits stable and flexible operation of the polymerization. | 2014-08-07 |
20140221604 | METHODS OF PRODUCING POLYANTHRACENE AND USES THEREOF - The present application provides methods of producing polyanthracene including polymerization of anthracene monomers in the presence of oxidants and reaction solvents. The present application further provides polyanthracene produced by methods described herein that has higher solubility in organic solvents and better thermal stability and ablation resistance. | 2014-08-07 |
20140221605 | NOVEL COORDINATION COMPLEXES AND PROCESS OF PRODUCING POLYCARBONATE BY COPOLYMERIZATION OF CARBON DIOXIDE AND EPOXIDE USING THE SAME AS CATALYST - Provided are a complex prepared from ammonium salt-containing ligands and having such an equilibrium structural formula that the metal center takes a negative charge of 2 or higher, and a method for preparing polycarbonate via copolymerization of an epoxide compound and carbon dioxide using the complex as a catalyst. When the complex is used as a catalyst for copolymerizing an epoxide compound and carbon dioxide, it shows high activity and high selectivity and provides high-molecular weight polycarbonate, and thus easily applicable to commercial processes. In addition, after forming polycarbonate via carbon dioxide/epoxide copolymerization using the complex as a catalyst, the catalyst may be separately recovered from the copolymer. | 2014-08-07 |
20140221606 | Aspart Proinsulin Compositions and Methods of Producing Aspart Insulin Analogs - Aspart modified proinsulin sequences that have a modified C-peptide amino acid and/or nucleic acid modification for producing aspart insulin analogs are provided. Highly efficient processes for preparing the aspart insulin analogs and improved preparations containing the aspart insulin analogs prepared according to the methods described herein are also provided. | 2014-08-07 |
20140221607 | MONOCLONAL ANTIBODY AND ANTIGENS FOR DIAGNOSING AND TREATING LUNG DISEASE AND INJURY - The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the hypervariable regions for a rat monoclonal antibody that binds to a form of EMAP II. This disclosure also includes a polypeptide sequence included in EMAP II that is the target for the binding of the antibody to its target protein. This epitope serves as the basis for a humanized antibody that can be used to treat patients that suffer from pathologies that exhibit elevated levels of EMAP II expression. | 2014-08-07 |
20140221608 | ACID-CLEAVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS - An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided. | 2014-08-07 |
20140221609 | Activation of Sodium Potassium ATPase - Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the alpha subunit of sodium potassium ATPase dramatically increase enzyme activity. There has never before been a report of precise activation sites or drug interaction sites for sodium potassium ATPase. Certain methods have also been discovered for treating or preventing diseases associated with low sodium potassium ATPase activity by administering antibodies, antibody fragments and small molecules that bind to the activation sites on the alpha subunit of sodium potassium ATPase. | 2014-08-07 |
20140221610 | DISPERSION AND DETACHMENT OF CELL AGGREGATES - Compositions comprising a protein or isolated peptide, and methods using the same for preventing, dispersing or detaching a biofilm, are disclosed. | 2014-08-07 |
20140221611 | BINDING MOLECULES FOR HUMAN FACTOR VIII AND FACTOR VIII-LIKE PROTEINS - It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure. | 2014-08-07 |
20140221612 | Peptides that Selectively Home to Heart Vasculature and Related Conjugates and Methods - The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof. | 2014-08-07 |
20140221613 | NOVEL MODIFIED PROTEIN COMPRISING TANDEM-TYPE MULTIMER OF MUTANT EXTRACELLULAR DOMAIN OF PROTEIN G - The purpose of the present invention is: to provide an excellent protein which is further reduced in the binding property to an Fc region of an immunoglobulin and/or the binding property to an Fab region of the immunoglobulin in a weakly acidic region compared with that of a protein containing an extracellular domain of wild-type protein G, and which still keeps a high antibody-binding activity in a neutral region; and to capture and collect an antibody readily using the protein without denaturating the antibody. The present invention relates to: a protein that is reduced in the binding property to an Fc region of an immunoglobulin and/or the binding property to an Fab region of the immunoglobulin in a weakly acidic region compared with that of a multimer comprising an extracellular domain of wild type one, which is a domain having a binding activity to a protein comprising an Fc region of immunoglobulin G, while keeping a high antibody-binding activity in a neutral region, and also has a binding activity to a protein comprising the Fc region of immunoglobulin G, wherein the protein comprises a tandem-type multimer of a mutant of the extracellular domain; and others. | 2014-08-07 |
20140221614 | COLLAGEN MATRIX WITH LOCALLY CONTROLLED INTRAFIBRILLAR AND EXTRAFIBRILLAR MINERAL CONTENT AND METHODS OF PRODUCING - A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration. | 2014-08-07 |
20140221615 | POROUS SCAFFOLD MATERIAL, AND METHOD FOR PRODUCING SAME - Provided are a scaffold material that functions as a scaffold material for two weeks or more in vivo and causes substantially no foreign-body reaction, and a method for producing the scaffold material. Specifically, a porous scaffold material comprising collagen fibers is provided. | 2014-08-07 |
20140221616 | HAPTENS OF QUETIAPINE - The invention relates to compounds of Formula I, wherein R | 2014-08-07 |
20140221617 | CANOLA PROTEIN PRODUCT WITH LOW PHYTIC ACID CONTENT ("C702") - Canola protein products having a protein content of at least about 60 wt % (N×6.25) d.b., preferably at least about 90 wt %, more preferably at lease about 100 wt %, and low phytic acid content, are produced by extracting canola seeds or canola oil seed meal with an aqueous calcium salt solution, preferably calcium chloride solution, to cause solubilization of canola protein from the seeds or meal. | 2014-08-07 |
20140221618 | TARGETED COAGULATION FACTORS AND METHOD OF USING THE SAME - Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A. | 2014-08-07 |
20140221619 | Methods and Compositions for Increasing Protein Production - The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50. | 2014-08-07 |
20140221620 | ANTI-HUMAN P-CADHERIN (CDH3) RECOMBINANT ANTIBODY - It is an object to provide a recombinant antibody that is an anti-CDH3 antibody having cytotoxicity on CDH3-expressing cells, which is anticipated to have fewer side effects than antibodies derived from animals other than humans and to maintain its therapeutic effects for a long period of time. The present invention provides a recombinant antibody which specifically reacts with an epitope existing in the amino acids at positions 108 to 131 or at positions 551 to 654 of the amino acid sequence shown in SEQ ID NO: 38 that is the extracellular region of human CDH3, and has cytotoxicity against CDH3-expressing cells. | 2014-08-07 |
20140221621 | SINGLE-CHAIN MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS - Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of using these of these libraries for the screening of single chain multivalent binding proteins using cell surface display technology (e.g., yeast display). | 2014-08-07 |
20140221622 | MONOVALENT BINDING PROTEINS - Engineered monovalent binding proteins that bind to one or more ligands (such as an antigen) via one binding domain are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease. | 2014-08-07 |
20140221623 | INTERLEUKIN-6 RECEPTOR BINDING POLYPEPTIDES - The invention relates to amino acid sequences that are directed against and/or that can specifically bind to IL-6 receptor, compounds or constructs that comprise said amino acid sequence, nucleic acids that encode said amino acid sequences, compounds or constructs, pharmaceutical compositions comprising said amino acid sequences, compounds or constructs as well as methods for the prevention and/or treatment of diseases and disorders associated with IL-6 receptor. | 2014-08-07 |
20140221624 | HUMANIZATION OF RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK - The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications. | 2014-08-07 |
20140221625 | B CELL LINEAGE BASED IMMUNOGEN DESIGN WITH HUMANIZED ANIMALS - Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious agents and pathogens are provided. Non-human animals with humanized immunoglobulin loci used in B-cell-lineage immunogen design in vaccine development are provided, as are methods of carrying out such design. | 2014-08-07 |
20140221626 | COMPOSITIONS AND METHODS FOR DETECTION OF METHADONE METABOLITE - Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly(amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings. Antibodies produced from immunogenic EDDP conjugates and labeled EDDP conjugates are employed in assays for determining the presence and/or amount of EDDP in samples suspected of containing EDDP. | 2014-08-07 |
20140221627 | METHODS FOR PREPARATION OF FUCOSE-LINKED SITE SPECIFIC CONJUGATES OF PROTEINS WITH TOXINS, ADJUVANTS, DETECTION LABELS AND PHARMACOKINETIC HALF LIFE EXTENDERS - The present invention relates to eukaryotic cells for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids. It also relates to methods for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and to molecules obtainable by said methods. It further relates to methods for producing conjugates comprising molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and pharmaceutical active compounds and to conjugates obtainable by said methods. In addition, the present invention relates to specific conjugates. | 2014-08-07 |
20140221628 | INFLUENZA VIRUS-LIKE PARTICLES COMPRISING ADJUVANT-FUSED M2 PROTEIN TO ENHANCE THE IMMUNOGENICITY OF VACCINE - A DNA vaccine comprising hyperglycosylated mutant HA gene, which is derived from avian influenza virus, is provided. A DNA vaccine composition comprising: (a) the DNA vaccine; and (b) a booster is also provided. An influenza virus-like particle comprising adjuvant-fused M2 protein is further provided. A method for eliciting an immune response against a plurality of avian influenza virus subtypes in a subject, comprising delivering the DNA vaccine or the DNA vaccine composition to tissue of the subject is also provided | 2014-08-07 |
20140221629 | Ultrafiltration Membranes and Methods of Making - The present invention is an integral multilayered composite membrane having at least one ultrafiltration layer made by cocasting or sequentially casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a multilayered composite membrane having at least one ultrafiltration layer. | 2014-08-07 |
20140221630 | METHOD AND SYSTEM FOR PROCESSING OF AQUATIC SPECIES - Disclosed herein is a method and system of recovering multiple products from industrial-scale production of a biomass of an aquatic species. | 2014-08-07 |
20140221631 | BORON-CONTAINING SMALL MOLECULES - This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate. | 2014-08-07 |
20140221632 | PHOTOCATALYTIC PREPARATION METHOD OF PARYLENE AF4 - The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture. | 2014-08-07 |
20140221633 | ONE-POT SYNTHESIS OF ALPHA/BETA-O-CLYCOLIPIDS - The present invention provides a one-pot method of preparing an unprotected α-O-glycolipid. The first step involves contacting a protected α-iodo sugar with a catalyst and a lipid comprising a hydroxy group, under conditions sufficient to prepare a protected α-O-glycolipid. The second step involves deprotecting the protected α-O-glycolipid under conditions sufficient to prepare the unprotected α-O-glycolipid, wherein the contacting and deprotecting steps are performed in a single vessel. The present invention also provides a one-pot method of preparing an unprotected β-O-glycolipid following the steps for the preparation of the unprotected α-O-glycolipid. | 2014-08-07 |
20140221634 | BIO-ACTIVE ANTIOXIDANTS FROM PLANT FOODS FOR NUTRACEUTICAL PRODUCT DEVELOPMENT - The present invention relates to 5-O-[ | 2014-08-07 |
20140221635 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of anslogs of halichondrin B are provided. | 2014-08-07 |
20140221636 | Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof - The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles. | 2014-08-07 |
20140221637 | NUCLEOSIDE ANALOG OR SALT THEREOF, OLIGONUCLEOTIDE ANALOG, GENE EXPRESSION INHIBITOR, AND NUCLEIC-ACID PROBE FOR DETECTING GENE - A nucleoside analog and a salt thereof represented by any of the general formulae (1) to (10) below: | 2014-08-07 |
20140221638 | MATRIX AND METHOD FOR PURIFYING AND/OR ISOLATING NUCLEIC ACIDS - The present invention relates to matrix materials suitable for use in purifying and/or isolating nucleic acids from a biological sample, which matrix comprises a surface comprising at least one element selected from the group consisting of Germanium, Tin and/or Lead, or at least one salt thereof, and methods related therewith. | 2014-08-07 |
20140221639 | RADIOLABELED NUCLEOSIDE ANALOGUE, AND PREPARATION METHOD AND USE THEREOF - A radiolabeled nucleoside analogue is provided, which includes radioactive iodine | 2014-08-07 |
20140221640 | ANTITUMOR AGENT - The objective of the present invention is to provide a highly safe antitumor agent having excellent antitumor activity and few side effects. The antitumor agent of the present invention is characterized in that it contains cellobiose as an active ingredient. | 2014-08-07 |
20140221641 | PROCESS FOR PREPARATION OF SUGAMMADEX - A novel process for the preparation of 6-perdeoxy-6-per-halo Gamma cyclodextrin which is a useful intermediate in the synthesis of Suggamadex is disclosed in the invention. The process involves by reacting Gamma cyclodextrin with phosphorous halide in presence of organic solvent. | 2014-08-07 |
20140221642 | LOW TEMPERATURE CHLORINATION OF CARBOHYDRATES - Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1′, and 6′ positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1′,6′-trichloro-4,1′,6′-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities. | 2014-08-07 |
20140221643 | FRUCTOSYLATED MANGIFERIN AND PREPARATION METHOD THEREFOR AND USE THEREOF - Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases. | 2014-08-07 |
20140221644 | NEW ROUTES TO TRANS A,B-SUBSTITUTED BACTERIOCHLORINS - Bacteriochlorin of Formula I: wherein R is H or silyl are described, along with compositions containing the same and methods of making and using the same. | 2014-08-07 |
20140221645 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | 2014-08-07 |
20140221646 | NOVEL IMMUNE SYSTEM MODULATORS - The present invention relates to a compound of Formula I: | 2014-08-07 |
20140221647 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention encompasses phenoxazine derivatives and methods of use thereof. | 2014-08-07 |
20140221648 | TH17 DIFFERENTIATION MARKERS FOR ACNE AND USES THEREOF - A method is described for using IL-12R 1/IL-23R, CCR6, BATF, AHR, STAT3, IRF4 crucial actors in Th17 cells differentiation as markers for acne. Also described are method of their use to diagnose acne, to screen inhibitors of Th17 differentiation. In particular, methods are described for inhibiting IL12R 1/IL-23R, CCR6, BATF, AHR, STAT3, IRF4 and the use of these screened inhibitors in acne treatment. | 2014-08-07 |
20140221649 | NOVEL COMPOUND - A novel compound suitable for obtaining a negative-type photosensitive resin composition capable of forming a pattern having favorable adhesiveness at a low light exposure. The compound is represented by the following formula (1). In the formula, R | 2014-08-07 |
20140221650 | 1 4,2-DIAZAPHOSPHOLIDINE DERIVATIVES - The present invention relates to novel 1,4,2-diazaphospholidine derivatives, to a process for preparation thereof and to use as catalysts. | 2014-08-07 |
20140221651 | PYRIDOPYRIMIDINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF - The present invention provides compounds of formula 1 as potential phosphodiesterase3 (PDE3) inhibitory agents and a process for the preparation thereof. The derivatives of formula 1 can be employed as therapeutics in human and veterinary medicine, where they can be used, for the treatment and prophylaxis of the following diseases: heart failure, dilated cardiomyopathy, platelet inhibitors, cancer and obstructive pulmonary diseases. | 2014-08-07 |
20140221652 | IMPROVED PROCESS FOR PREPARATION OF IMATINIB AND ITS MESYLATE SALT - Disclosed is a process for the preparation of imatinib of formula (I), or its mesylate salt with controlled level of genotoxic impurity of formula (II), a key intermediate for imatinib. | 2014-08-07 |
20140221653 | Prodrugs of NH-Acidic Compounds - The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment. | 2014-08-07 |
20140221654 | PROTEASE INHIBITORS - Compounds of the formula II: | 2014-08-07 |
20140221655 | MODIFIED POLYAROMATIC HYDROCARBONS AND POLYHETEROCYCLICS FOR OPTOELECTRONICS - The invention provides methods for substituting polyaromatic hydrocarbons or polyheterocyclic compounds with perfluoroalkyl groups. The methods can include heating a polyaromatic hydrocarbon substrate or a polyheterocyclic compound substrate in the presence of a perfluoroalkyl iodide, typically in a closed system, wherein the heating is sufficient to bring both the polyaromatic hydrocarbons or polyheterocyclic compound, and the perfluoroalkyl iodide, into the gas phase, thereby allowing the substrate to react with the perfluoroalkyl iodide in the gas phase to form polyaromatic hydrocarbons or polyheterocyclic compounds having one or more perfluoroalkyl substituents. The methods allow for the creation of versatile libraries of novel perfluoroalkyl-containing derivatives that can serve as important building blocks and active components in biomedical, electronic, and materials applications. | 2014-08-07 |
20140221656 | CRYSTALLINE SOLVATES OF 6-(PIPERIDIN-4-YLOXY)-2H-ISOQUINOLIN-1-ONE HYDROCHLORIDE - The present invention relates to crystalline solvates of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and the use thereof. | 2014-08-07 |
20140221657 | ALPHA HELIX MIMETIC COMPOSITIONS FOR TREATING CANCER AND OTHER CBP/CATENIN-MEDIATED DISEASES AND CONDITIONS - Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed. | 2014-08-07 |
20140221658 | INHIBITION OF CELL PROLIFERATION - The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC | 2014-08-07 |
20140221659 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS - The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds. | 2014-08-07 |
20140221660 | METHOD FOR SYNTHESIZING PIRFENIDONE - A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone. | 2014-08-07 |
20140221661 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE - The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate. | 2014-08-07 |
20140221662 | INTERMEDIATE COMPOUNDS OF TAMIFLU, METHODS OF PREPARATION AND USES THEREOF - Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds. | 2014-08-07 |
20140221663 | PROCESS FOR THE PREPARATION OF BENZOHETERO [1,3] - DIAZOLE COMPOUNDS DISUBSTITUTED WITH HETEOARYL GROUPS - Process for the preparation of a benzohetero[1,3]diazole compound disubstituted with heteroaryl groups which comprises reacting at least one benzohetero[1,3]diazole compound disubstituted with at least one heteroaryl compound. Said benzohetero[1,3]diazole compound disubstituted with heteroaryl groups can be advantageously used in the construction of luminescent solar concentrators (LSC). Furthermore, said benzohetero[1,3]diazole compound disubstituted with heteroaryl groups can be advantageously used in the construction of photovoltaic devices such as, for example, photovoltaic cells, photovoltaic modules, solar cells, solar modules, on both a rigid and flexible support. Said benzohetero[1,3]diazole compound disubstituted with heteroaryl groups can also be advantageously used as a precursor of monomeric units in the preparation of semiconductor polymers. | 2014-08-07 |
20140221664 | COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING (ELECTRON WITHDRAWING GROUPS) - The inventions disclosed and described herein relate to new and efficient generic methods for making a wide variety of compounds having HAr—Z-Har tricyclic cores, wherein HAr is an optionally substituted five or six membered heteroaryl ring, and Hal is a halogen, and Z is a bridging radical, such as S, Sc, NR | 2014-08-07 |
20140221665 | LUMINESCENT SUBSTRATE FOR LUCIFERASE - An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position. | 2014-08-07 |
20140221666 | HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE - The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis. | 2014-08-07 |
20140221667 | FACTOR VIIA INHIBITOR - The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed. | 2014-08-07 |
20140221668 | Process - The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se. | 2014-08-07 |
20140221669 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER - The present disclosure provides a novel and economically advantageous process for preparation of compounds of Formula I, such as alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester. The process includes acidification of the sodium enolate of alkyl difluoroacetoacetate by carbonic acid generated in situ by reacting carbon dioxide with water. The disclosure also includes promoting the ring closure reaction in which alkyl 2-alkomethylene-4,4-difluoro-3-oxobutyrate is reacted with methylhydrazine in two phase system with a weak base such as Na | 2014-08-07 |
20140221670 | 4-HYDROXY-2-OXO-1-PYRROLIDINEACETAMIDE RACEMATE CRYSTAL FORM I AND PREPARATION METHOD THEREFOR - Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production. | 2014-08-07 |
20140221671 | PROCESS FOR PRODUCING A SOLID OXIDIC MATERIAL - The present invention relates to a process for producing a porous solid oxidic material from a hydrogel of the oxidic material and to the porous solid oxidic material as such. | 2014-08-07 |
20140221672 | Process for Preparing Carbonate and Diol Products - A method of forming a cyclic carbonate product is carried out by reacting an alkylene oxide, such as ethylene oxide, with carbon dioxide in the presence of a metal organic framework (MOF) catalyst with less than 0.5 mol % of any potassium or quaternary ammonium salts present based on moles of alkylene oxide feed in a reaction zone under reaction conditions to form a cyclic carbonate product. The cyclic carbonate product may be optionally fed as a crude carbonate product that does not undergo any purification or separation, other than the optional removal of any portion of unreacted alkylene oxide, carbon dioxide, and light hydrocarbon gases, to a second reaction zone containing a transesterification catalyst along with an aliphatic monohydric alcohol. The cyclic carbonate product and monohydric alcohol are allowed to react under reaction conditions to form the dialkyl carbonate and diol products. | 2014-08-07 |
20140221673 | RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN AND POLYMERIC COMPOUND - A resist composition including a base component (A) which exhibits changed solubility in a developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the base component (A) containing a polymeric compound (A1) having a structural unit (a5) represented by general formula (a5-0) shown below (R | 2014-08-07 |
20140221674 | PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES - The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols. | 2014-08-07 |
20140221675 | PROCESS OF CONVERTING LOW AND HIGH FREE FATTY ACID CONTAINING OILS INTO NO FREE FATTY ACID CONTAINING OILS - A system and method for the conversion of high free fatty acid (HFFA) containing oils defined as oils containing 20-100% free fatty acids (FFA) and low free fatty acid (LFFA) containing oils defined as oils containing 1-20% free fatty acids (FFA) into oil with less than 0.5% FFA (defined as NFFA oil) includes a combination of partial glycerolysis of HFFA oils to produce LFFA oils and subsequent stripping of LFFA oils to produce NFFA oils via steam distillation. | 2014-08-07 |
20140221676 | COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASE - In various embodiments, the present invention provides pharmaceutical compositions comprising fatty acids and methods for treating subjects using same. | 2014-08-07 |
20140221677 | Hydrolysis Of Organochlorosilanes In Tube Bundle Reactor - A process for hydrolyzing organochlorosilanes involves reacting organochlorosilanes with water in a tube bundle reactor to form a polyorganosiloxane-containing crude hydrolyzate and hydrogen chloride. | 2014-08-07 |
20140221678 | ORGANOSILICON COMPOUND HAVING CONJUGATED DIENE STRUCTURE AND MAKING METHOD - The invention provides a conjugated diene structure-containing organosilicon compound having formula (1): | 2014-08-07 |
20140221679 | GOLD-CATALYZED SYNTHESIS OF CARBONATES AND CARBAMATES FROM CARBON MONOXIDE - The invention provides a method for producing organic carbonates via the reaction of alcohols and carbon monoxide with oxygen adsorbed on a metallic gold or gold alloy catalyst. | 2014-08-07 |
20140221680 | 4-Acylaralkylphenols and Derivatives Thereof - 4-Aralkylphenols and derivatives thereof expressed by general formulas (6) and (7) are useful for producing trisphenols. | 2014-08-07 |
20140221681 | FLUORINATION OF ACRYLATE ESTERS AND DERIVATIVES - The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent. | 2014-08-07 |
20140221682 | SYNTHESIS AND BIOLOGICAL STUDIES OF AN ISOMERIC MIXTURE OF (E/Z) ISOXYLITONES AND ITS ANALOGUES - The invention relates to an anti-epileptic isoxylitone, 2,2′-(3,5,5-Trimethyl-2-cyclohexen-1-ylidene) acetic acid. | 2014-08-07 |
20140221683 | PROCESS FOR PRODUCING A CATALYTICALLY ACTIVE COMPOSITION BEING A MIXTURE OF A MULTIELEMENT OXIDE COMPRISING THE ELEMENTS MO AND V AND AT LEAST ONE OXIDE OF MOLYBDENUM - A process for producing a catalytically active composition being a mixture of a multielement oxide comprising the elements Mo and V and at least one oxide of molybdenum, in which spray drying of an aqueous solution or of an aqueous suspension of starting compounds comprising the elements of the multielement oxide produces a spray powder P, a pulverulent oxide of molybdenum and optionally shaping assistants are added thereto, shaped bodies are shaped from the resulting mixture and these are converted to the catalytically active composition by thermal treatment. | 2014-08-07 |
20140221684 | Electrochemical Co-Production of Chemicals Utilizing a Halide Salt - The present disclosure includes a system and method for co-producing a first product and a second product. The system may include a first electrochemical cell, at least one second reactor, and an acidification chamber. The method and system for co-producing a first product and a second product may include co-producing a carboxylic acid and at least one of an alkene, alkyne, aldehyde, ketone, or an alcohol while employing a recycled halide salt. | 2014-08-07 |
20140221685 | METHOD FOR PRODUCING BARIUM TITANYL SALT AND BARIUM TITANATE - A method for producing a high-quality barium titanyl salt includes using, as the fluids to be treated, at least two kinds of fluids, namely, a barium titanium mixed solution that is obtained by dissolving both a barium compound and a titanium compound in a solvent, a compound solution that is obtained by dissolving, in a solvent, a compound capable of deposing the barium and titanium contained in the barium-titanium mixed solution into a barium titanyl salt, and if necessary, one or more other fluids; and mixing these fluids together in a thin film fluid formed at least between two treating surfaces and to form a barium titanyl salt. The treating surfaces are so arranged as to face each other in an approachable/separable state with one of the treating surfaces and being capable of turning relatively to the other. | 2014-08-07 |