32nd week of 2009 patent applcation highlights part 38 |
Patent application number | Title | Published |
20090197261 | APTAMER- AND NUCLEIC ACID ENZYME-BASED SYSTEMS FOR SIMULTANEOUS DETECTION OF MULTIPLE ANALYTES - The present invention provides aptamer- and nucleic acid enzyme-based systems for simultaneously determining the presence and optionally the concentration of multiple analytes in a sample. Methods of utilizing the system and kits that include the sensor components are also provided. The system includes a first reactive polynucleotide that reacts to a first analyte; a second reactive polynucleotide that reacts to a second analyte; a third polynucleotide; a fourth polynucleotide; a first particle, coupled to the third polynucleotide; a second particle, coupled to the fourth polynucleotide; and at least one quencher, for quenching emissions of the first and second quantum dots, coupled to the first and second reactive polynucleotides. The first particle includes a quantum dot having a first emission wavelength. The second particle includes a second quantum dot having a second emission wavelength different from the first emission wavelength. The third polynucleotide and the fourth polynucleotide are different. | 2009-08-06 |
20090197262 | BORDETELLA DETECTION ASSAY - Disclosed herein are methods and compositions for detecting | 2009-08-06 |
20090197263 | Compare-MS: Method Rapid, Sensitive and Accurate Detection of DNA Methylation - The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer. | 2009-08-06 |
20090197264 | METHOD FOR PREDICTION OF SENSITIVITY TO 5-FLUOROURACIL-TYPE ANTICANCER AGENT - A factor affecting sensitivities to anticancer agents is analyzed and the validity of the factor is demonstrated. | 2009-08-06 |
20090197265 | EPIGENETIC ANALYSES - A method of carrying out epigenetic analysis on an analyte biological sample, the method comprising carrying out chromatin immunoprecipitation on an analyte biological sample, characterised in that the method comprises a step of contacting the analyte biological sample with carrier chromatin. The method of the invention wherein the analyte biological sample comprises less than one million cells. The method of the invention wherein the analyte biological sample comprises less than about 6 μg of DNA and/or less than about 12 μg of chromatin. | 2009-08-06 |
20090197266 | METHODS FOR OPTIMIZING CLINICAL RESPONSIVENESS TO METHOTREXATE THERAPY USING METABOLITE PROFILING AND PHARMACOGENETICS - The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the individual. The present invention also provides methods for generating a pharmacogenetic index for predicting clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. In addition, the present invention provides methods for optimizing therapeutic efficacy of chemotherapy in an individual by calculating the level of at least one long-chain MTXPG in a sample obtained from the individual. | 2009-08-06 |
20090197267 | METHODS FOR OPTIMIZING CLINICAL RESPONSIVENESS TO METHOTREXATE THERAPY USING METABOLITE PROFILING AND PHARMACOGENETICS - The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the individual. The present invention also provides methods for generating a pharmacogenetic index for predicting clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. In addition, the present invention provides methods for optimizing therapeutic efficacy of chemotherapy in an individual by calculating the level of at least one long-chain MTXPG in a sample obtained from the individual. | 2009-08-06 |
20090197268 | METHODS FOR OPTIMIZING CLINICAL RESPONSIVENESS TO METHOTREXATE THERAPY USING METABOLITE PROFILING AND PHARMACOGENETICS - The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the individual. The present invention also provides methods for generating a pharmacogenetic index for predicting clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. In addition, the present invention provides methods for optimizing therapeutic efficacy of chemotherapy in an individual by calculating the level of at least one long-chain MTXPG in a sample obtained from the individual. | 2009-08-06 |
20090197269 | Translocation and mutant CSF1R Kinase in human leukemia - In accordance with the invention, a novel gene translocation, (3p21, 5q33), in human myelogenous leukemia (AML) that results in a fusion protein combining part of RNA Binding Protein-6 (RBM6) with Macrophage Colony Stimulating Factor-1 Receptor (CSF1R) kinase has now been identified. The RBM6-CSF1R fusion protein and truncated CSF1R kinase itself, which both retain CSF1R tyrosine kinase activity, were confirmed to drive the proliferation and survival of acute megakaryoblastic leukemia (AML-M7). The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant CSF1R kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein and truncated kinase enables new methods for determining the presence of these mutant CSF1R kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 2009-08-06 |
20090197270 | DIAGNOSTIC ASSAY FOR SPONGIFORM ENCEPHALOPATHIES - The invention provides a method of diagnosis of a spongiform encephalopathy in a diagnostic sample of a valid body tissue taken from a subject, which comprises detecting an increased proteolytic activity in the diagnostic sample, compared with a sample from a control subject. | 2009-08-06 |
20090197271 | FUNCTIONAL NUCLEIC ACID LIGANDS TO FLUORESCENT PROTEINS - The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular complex are also disclosed. The invention also relates to a system containing a first DNA molecule encoding the nucleic acid aptamer of the present invention and a second DNA molecule encoding a fluorescent protein capable of being bound by the first domain. Methods of detecting a molecular target and determining location of a molecular target using the nucleic acid aptamer of the invention are also disclosed. | 2009-08-06 |
20090197272 | VITRO METHOD OF DETECTING AND/OR DIAGNOSING CANCER USING UV LIGHT BASED DNA IMAGE CYTOMETRY - The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles. The invention also relates to an in vitro method of diagnosing or predicting the likely occurrence of cancer in a human or animal subject. | 2009-08-06 |
20090197273 | NOVEL N-ACETYLGALACTOSAMINE TRANSFERASES AND NUCLEIC ACIDS ENCODING THE SAME - An enzyme which transfers N-acetylgalactosamine to N-acetylglucosamine via a β1-4 linkage was isolated and the structure of its gene was explained. This led to the production of said enzyme or the like by genetic engineering techniques, the production of oligosaccharides using said enzyme, and the diagnosis of diseases on the basis of said gene or the like. | 2009-08-06 |
20090197274 | BIOLOGICAL SAMPLE REACTION CHIP AND BIOLOGICAL SAMPLE REACTION METHOD - A biological sample reaction chip, including: a plurality of reaction containers; a reaction liquid introduction channel having a reaction liquid supply opening at a first end and an evacuation opening at a second end; and a reaction liquid quantifying channel, a third end of which is connected to one of the reaction containers, and a fourth end of which is connected to the reaction liquid introduction channel, wherein an interior of each of the reaction containers is coated with a reagent that is necessary for a reaction. | 2009-08-06 |
20090197275 | Controls For Detecting Methicillin Resistant Staphylococcus Aureus (MRSA) - The invention relates to the quality control of | 2009-08-06 |
20090197276 | METHODS AND COMPOSITIONS FOR PREDICTING COMPLIANCE WITH AN ANTIDEPRESSANT TREATMENT REGIMEN - Methods and compositions are provided for predicting whether a subject will comply with an antidepressant treatment regimen. In practicing the subject methods, a subject's serotonin transporter gene-linked polymorphic region ( | 2009-08-06 |
20090197277 | High Density Plate Filler - A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise an assay input port extending from the first surface to the second surface and at least one pressure nodule extending from the second surface. An output layer can comprise a plurality of staging capillaries each having an inlet and an outlet. A intermediate layer can be disposed between the assay input layer and the output layer. The intermediate layer can be flexible and comprise a plurality of microfluidic channels and a flow aperture being in fluid communication with the assay input port and the plurality of microfluidic channels. The assay input layer can be moveable relative to the intermediate layer such that the at least one pressure nodule engages the intermediate layer to apply a clamping force on at least a portion of one of the plurality of microfluidic channels to reduce flow of the assay therethrough. | 2009-08-06 |
20090197278 | Antibodies to hADA2 - Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides. | 2009-08-06 |
20090197279 | MICROTUBULE SYNTHESIS AS A BIOMARKER - Stable isotope labeling was used to measure dynamics of tubulin incorporation into microtubule subpopulations representing different neuronal compartments in the murine hippocampus. Neuronal microtubules were largely static. Basal turnover was highest in tau-associated (axona) and growth cone), lower in MAP2-associated (somatodendritic), and lowest in cold stable (axonal shaft) subpopulations. Intracerebroventricular glutamate injection stimulated label incorporation into axonal shaft and somatodendritic microtubules, the latter dependent on cAMP-PKA. Hippocampus-dependent memory formation after contextual fear conditioning was accompanied by increased assembly of MAP2- and cold stable-microtubules. Both microtubule assembly and memory formation were inhibited by the microtubule depolymerizing drug, nocodazole. This approach allows for correlation with behavioral measures of learning and memory and for the screening of candidate agents for stimulatory activities on learning memory. | 2009-08-06 |
20090197280 | Methods and Devices for Rapid Assessment of Severity of Injury - Methods and devices for rapid assessment of the severity of injury not due to a natural disease based upon measurement of neutrophil gelatinase-associated lipocalin (NGAL) are provided. | 2009-08-06 |
20090197281 | METHODS FOR DIAGNOSIS AND TREATMENT OF CHRONIC IMMUNE DISEASES - Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence of native Stat-1 protein and/or any lower molecular weight fragments of Stat-1 protein present. The assay results are used to diagnose the presence of chronic immune disease activity and/or characterize chronic immune disease activity in the subject, e.g., to confirm an initial chronic immune disease diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. In certain embodiments, the assay results are also used to predict the effectiveness of a particularly treatment protocol, e.g., to determine whether an interferon based treatment protocol will be effective. In addition, methods of Stat-1 based methods of treating chronic immune disease conditions are provided. Also provided by the subject invention are kits for practicing the methods. | 2009-08-06 |
20090197282 | METHOD AND SYSTEM FOR SCREENING THE RECEPTOR-LIGAND BINDING IN LIVE CELL - The invention relates to methods and system for detecting ligand binding to membrane receptors and endocytosis. A method for detecting ligand binding to a membrane receptor includes the steps of: incubating the cell with a dye and a ligand; and detecting dye-containing endocytic vesicles in the cell. A system for screening ligand binding to membrane receptors includes an automatic liquid handling device; an x-y stage for positioning a plate; a microscope configured to image endocytic vesicles of a cell; a software for automatic analysis of FM spots (endocytic vesicles); and a control unit configured to control the movement of the x-y stage and the microscope. | 2009-08-06 |
20090197283 | DEVICES AND METHODS FOR THE COLLECTION AND DETECTION OF SUBSTANCES - The present invention is a single self-contained device for collecting, transferring, extracting, and testing for the presence of a target analyte in a sample obtained from a surface by swabbing, solid materials (pills, capsules, unknown powders), air samples and biological and non-biological fluids. The device includes a swab, a retention well including eluent fluid, and analysis technologies which can include but are not limited to lateral flow testing analysis. The major improvement is the invention of rinsing the swab with proprietary elution fluid prior to testing thereby not compromising the chemistry and allowing for a wide variety of applications under extremely hot or cold field conditions. Also, the device is in one self-contained unit instead of having a separate water dropper or spray. Moreover, the shape of the device is similar to a magic marker so it is more substantial than any drug tester on the market, as well in certain embodiments it can have grips resembling a gun and in certain embodiments can even emit sounds or smells when a surface is wiped or a positive test is attained | 2009-08-06 |
20090197284 | Analysis of Proteins from Biological Fluids Using Mass Spectrometric Immunoassay - Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound compounds are rinsed from the extraction devices using a series of buffer and water rinses, after which the wild type protein (and/or its variants) are eluted directly onto a target in preparation for analysis such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Mass spectrometry of the eluted sample then follows with the retained proteins identified via accurate molecular mass determination. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to a working curves constructed from samples containing known concentrations of the protein or variants. Such MSIA devices, kits and methods have significant application in the fields of; basic research and development, proteomics, protein structural characterization, drug discovery, drug-target discovery, therapeutic monitoring, clinical monitoring and diagnostics, as well as in the high throughput screening of large populations to establish and recognize protein/variant patterns that are able to differentiate healthy from diseased states. | 2009-08-06 |
20090197285 | Lung Cancer Diagnostic Assay - A diagnostic assay for determining presence of lung cancer in a patient depends, in part, on ascertaining the presence of an antibody associated with lung cancer. The assay predicted lung cancer prior to evidence of radiographically detectable cancer tissue. | 2009-08-06 |
20090197286 | Methods and Kit for Diagnosing T1DM - A method of diagnosing Type 1 Diabetes Mellitus (T1DM) in a subject in need thereof is provided. The method comprising determining a presence and/or a level of antibodies in a biological sample of the subject, wherein the presence or level above a predetermined threshold is indicative of T1DM, thereby diagnosing T1DM in the subject. Also provided are a kit for diagnosing T1DM and a method of monitoring anti diabetic treatment. | 2009-08-06 |
20090197287 | SYSTEMS AND METHODS FOR CHARACTERIZING KIDNEY DISEASE - The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders. | 2009-08-06 |
20090197288 | MULTIPLE QUANTIFICATION OF CHOLESTEROL IN LOW DENSITY LIPOPROTEIN - The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method is used for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol in a biological sample, whereby cholesterol in low density lipoprotein and total cholesterol in a biological sample are quantified with a single measurement. | 2009-08-06 |
20090197289 | METHOD FOR CONFIRMING A DIAGNOSIS OF AUTISM - A method for confirming a diagnosis of autism in of an individual comprises obtaining a sample of feces from an individual, determining a quantitative level of chymotrypsin present in the sample, and comparing the quantitative level of fecal chymotrypsin in the stool sample of the person having autism to a stool sample from an individual that has a normal fecal chymotrypsin level and does not have autism and confirming a diagnosis of autism based on the measurement of the quantitative level of fecal chymoptrypsin. | 2009-08-06 |
20090197290 | Methods and Kits for Diagnosis of Non-Septic Shock - Methods and kits for diagnosis and staging of non-septic shock are presented in which one or more protease activities are measured from a biological sample to so identify and/or stage non-septic shock. Most preferably, at least two protease activities are correlated, however, additional or alternative markers may also be measured. | 2009-08-06 |
20090197291 | Assays Using Nanoparticles - A method for quantitatively and qualitatively determining the presence of a macromolecule comprises providing nanoparticles in a buffered solution, adding a test sample to the buffered nanoparticle solution, and measuring the difference between the buffered nanoparticles in the presence and absence of the test sample. The nanoparticles are preferably less than 100 nm in size. | 2009-08-06 |
20090197292 | SYSTEMS AND METHODS FOR EX VIVO LUNG CARE - Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas. | 2009-08-06 |
20090197293 | NOVEL USE OF AN INDICATOR CELL LINE FOR BIOASSAY - The present invention relates to methods of bioassay for detecting the effective concentration of Granulocyte Colony Stimulating Factor (G-CSF), and estimating ED | 2009-08-06 |
20090197294 | MRD-BASED REACTORS - The present invention depicts an MRD-based reactor. The MRD-based reactor comprises of a means for containing a flowing media and reacting the same (reactor). The reactor is characterized by a continuous wall portion, and is in connection with at least one MRD, adapted for applying localized spectroscopy towards the media. MRD-based reactors, in which the MRD is at least partially inside the reactor or reaction media, and those in which the MRD accommodates the reactor, are also introduced. Lastly, the invention teaches an in situ method for controlling and analyzing of a reaction. The method comprises of providing an MRD-based reactor; applying a magnetic field within the reactor, especially for performing a plurality of localized spectroscopic measurements and either real time or offline analyzing and/or controlling of reactions in the flowing media. | 2009-08-06 |
20090197295 | MASKS USEFUL FOR MALDI IMAGING OF TISSUE SECTIONS, PROCESSES OF MANUFACTURE AND USES THEREOF - The present invention relates to masks for use in mass spectrometry, in particular MALDI, tissue section analysis, comprising a plate made of or coated by an opaque material and having a thickness of less than 150 μm, said plate comprising regularly spaced openings, wherein in the plate upper plane, the diameter D of the largest circle comprising only one opening is superior to the diameter d of a mass spectrometer, in particular a MALDI analyzer, laser beam divided by sin Θ, wherein Θ is the mass spectrometer, in particular a MALDI analyzer, laser beam incidence angle with respect to the sample plane. The invention also concerns processes of manufacture of the masks according to the invention, the use thereof for mass spectrometry, in particular MALDI, imaging of tissue sections, and a method for MALDI imaging of a tissue section using said masks. | 2009-08-06 |
20090197296 | Optical Indicator for Detecting Bacterial Pathogens - A clinical testing assay device that can differentiate bacterial from viral infections is described. The assay device has a sample contact zone with an absorbent pad on which a test sample is deposited and a detection zone with a colorant indicator that is sensitive to bacteria cells. The colorant indicator changes color when exposed to a bacteria sample. The color change signal can manifest relatively quickly, usually within a few minutes, and with an intensity correlative to the concentration of bacteria in a test sample. A method of use is also provided. | 2009-08-06 |
20090197297 | Molecularly Imprinted Polymer Sensor Device - A molecularly imprinted polymer sensor device for detecting the presence of a taggant molecular structure in a fluid is disclosed. The molecularly imprinted polymer sensor device comprises a molecularly imprinted crosslinked polymer having a crosslinked core and a plurality of polymer arms attached to the core, wherein the core has molecular sized cavities adapted to selectively receive and bind displacement molecules having the taggant molecular structure and a colorimetric indicator, said displacement molecule being selectively removed from the molecularly imprinted crosslinked polymer and replaced with the taggant molecular structure upon exposure to the fluid containing the taggant molecular structure therein, thereby indicating the presence of the taggant molecular structure in the fluid. | 2009-08-06 |
20090197298 | METHOD FOR DETECTING MICROORGANISMS IN A BIOLOGICAL SAMPLE - This invention relates to a method for detecting at least one specific microorganism in a biological sample, said method comprising the following steps: a) culturing said biological sample in a culture medium, b) subjecting said culture medium to at least two radiations each presenting a specific wavelength, c) obtaining at least two different images of said culture medium using at least two reading systems, d) combining said at least two different images to produce at least one combined artificial image, and e) analyzing said combined artificial image to detect the presence of said at least one specific microorganism in the biological sample. The invention also relates to a device for application of the detection method according to this invention. | 2009-08-06 |
20090197299 | Method for Assessing Airborn Microorganisms - The present invention relates to an environmental sampling method for assessing airborne microorganisms. The method comprises retaining organisms suspended in air to a polymeric pad via gravitational settling or forced impact, dissolving the polymeric pad in a buffered salt solution, and determining the number and kind of microorganisms in the buffered salt solution. Neither the polymeric pad nor the buffered salt solution inhibits the growth of the microorganisms to be determined. | 2009-08-06 |
20090197300 | MUTUALLY EXCLUSIVE DOMAIN FOLDING MOLECULAR SWITCH AND METHOD OF SYNTHESIS THEREOF - The invention is a fusion protein, embodying a mutually exclusive folding domain molecular switch, wherein the free energy released by folding of a first domain of the fusion protein drives an unfolding of a second domain of the fusion protein, and vice versa. The fusion protein is engineered so that folding the first domain unfolds the second domain, and vice versa, making the folded and unfolded states of the domains mutually exclusive. This is accomplished by insertion of an insert protein GCN4 into a surface loop of a target, protein barnase, subject to die topological design, criterion that the N—C terminal length of GCN4 be at least two-times greater than the Cα-Cα length of a surface loop of barnase. In the absence of the ligand AP-1, barnase is more stable and is folded and active. The presence of AP-1 induces folding of GCN4, forcibly unfolding and inactivating barnase. | 2009-08-06 |
20090197301 | Secreted and transmembrane polypeptides and nucleic acids encoding the same - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 2009-08-06 |
20090197302 | Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Attenuated Expression of the nac Gene - The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus | 2009-08-06 |
20090197303 | PROCESS FOR PRODUCING DIPEPTIDES - The present invention provides: a protein having dipeptide-synthesizing activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant transformed with the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity using the transformant or the like; a process for producing a dipeptide using the protein having dipeptide-synthesizing activity; and a process for producing a dipeptide using, as an enzyme source, a culture of a transformant or a microorganism which produces the protein having dipeptide-synthesizing activity or the like. | 2009-08-06 |
20090197304 | Corynephage integrase-based site-specific insertion vector system - The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into the genome of different hosts. Methods of using the vectors and transformed hosts are described. | 2009-08-06 |
20090197305 | PROCESS FOR THE PREPARATION OF POLYMYXIN B EMPLOYING (PAENI) BACILLUS POLYMYXA - The invention is related to the process of fermentation with production strain | 2009-08-06 |
20090197306 | THERMAL CYCLING DEVICE - A multi-layer device suitable for thermal cycling is set forth. The device is particularly suitable for performing a polymerase chain reaction (PCR). One embodiment includes a first layer ( | 2009-08-06 |
20090197307 | COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS - The invention provides methods of preparing nucleic acids, such as RNA molecules, of a defined size or range of sizes. The invention provides compositions, methods and kits for use in the production and preparation of small RNA molecules (including without limitation micro-RNA, siRNA, d-siRNA and e-siRNA) and other nucleic acids of various sizes. | 2009-08-06 |
20090197308 | Enzymatic synthesis of sulfated polysaccharides - A method of sulfating a polysaccharide is provided. The method can include providing a reaction mixture comprising at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS); incubating a polysaccharide substrate with the reaction mixture, wherein production of the sulfated polysaccharide from the polysaccharide substrate is catalyzed by the OST enzyme with a conversion of the PAPS to adenosine 3′,5′-diphosphate (PAP); and providing a reaction condition which modifies PAP to reduce an inhibitory effect of PAP on the polysaccharide sulfation. | 2009-08-06 |
20090197309 | Mutant Acetolactate Synthase and a Method for Producing Branched-Chain L-Amino Acids - A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine. This acetolactate synthase contains a mutant small subunit encoded by the mutant ilvN gene. | 2009-08-06 |
20090197310 | BIOSYNTHESES OF SALINOSPORAMIDE A AND ITS ANALOGS AND RELATED METHODS OF MAKING SALINOSPORAMIDE A AND ITS ANALOGS - Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions. | 2009-08-06 |
20090197311 | METHOD FOR THE PRODUCTION OF SIMVASTATIN - The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process. | 2009-08-06 |
20090197312 | Production of fat from alcohol - The present invention concerns a process for forming a lipid or a mixture of lipids from a starting material, which comprises at least one alcohol and a soap or a soap precursor, the process comprising adding a metal-ion forming agent to the starting material, whereby a mixture is formed, which contains an insoluble phase and a liquid phase, separating the insoluble phase from the liquid phase, contacting the lipid-producing microorganism with the liquid phase on a culturing substrate, whereby the microorganism cells begin producing lipid, and collecting the lipids. The present invention also concerns a process for forming a lipid or a mixture of lipids from an alcohol-containing liquid phase, which comprises at least one alcohol. | 2009-08-06 |
20090197313 | METHOD FOR PREPARING XYLITOL WITH HIGH YIELD USING RECYCLING MICROORGANISM - Provided is a process for continuously producing xylitol in high yield and productivity using a vacuum microfiltration bioreactor containing a fermentation medium for a strain of the genus | 2009-08-06 |
20090197314 | Modified Microorganisms with Inactivated Lactate Dehydrogenase Gene - Modified microorganisms are prepared by inactivation of the endogenous lactate dehydrogenase gene. The microorganisms are deposited under NCIMB Accession Nos. 41277, 41278, 41279, 41280 or 41281. | 2009-08-06 |
20090197315 | FULLERENE-BASED AMINO ACIDS - The present invention is directed to a series of new compounds, combining the unique properties of fullerenes and bio-active amino acid residues, and to methods for making such compounds. The present invention is directed toward fullerene-based amino acids, and to amino acid residues, peptide chains, proteins, and polypeptides made from such fullerene-based amino acids. The present invention is further directed to amino acid residues, peptide chains, proteins, and polypeptides comprising such fullerene-based amino acids and into which such fullerene-based amino acids have been incorporated. Exemplary compounds have been prepared, and these compounds have been characterized and confirmed with infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), etc. These new compounds, which are additions to the existing amino acid residue family, may potentially possess useful pharmaceutical application and may provide a new platform for further exploration in cancer therapy, and peptide and protein engineering. | 2009-08-06 |
20090197316 | PROCESS FOR PREPARING PARTICLES OF PROTEINACEOUS MATERIAL - Protein particles are prepared by causing or allowing protein molecules dispersed in a liquid medium at a concentration of 8 mg.mL-1 or greater to react in the presence of a zero-length crosslinker, so as to produce protein particles comprising protein molecules that are covalently bonded together. The protein particles may be produced with sizes in the sub-micron range with closely defined sizes and size distributions. The particles have applications in many fields, but are useful inter alia for the delivery of therapeutic agents and other agents, eg imaging contrast agents, to the body. | 2009-08-06 |
20090197317 | TSG-Like Gene - A gene encoding a novel protein that is homologous to | 2009-08-06 |
20090197318 | CRYSTALLIZATION OF ENZYME AND METHOD FOR PRODUCING SAME - The present invention provides a method of crystallizing of enzymes. The method is for rapidly crystallizing enzymes from impure mixtures. The method is simple and cheap, and it is compatible to industrial requirements. T1 lipase was able to form crystals at low protein concentration (2.5 mg/ml) in a day. High temperature crystallization was obtained from the method. The present invention also relates to a composition of a crystallized lipase produced from the said method. | 2009-08-06 |
20090197319 | Virus-Like Particle Containing A Dengue Recombinant Replicon - A diagnostic assay for detecting antibody, in part, to human papilloma virus includes a virus-like particle that expresses human papilloma virus antigen. | 2009-08-06 |
20090197320 | ANCESTRAL DENGUE VIRUS ENVELOPE PROTEIN - Disclosed is a dengue virus envelope protein sequence derived via ascertainment of a most recent common ancestor of the three dengue serotype variants, DENV-1, DENV-2, DENV-3 and DENV-4. This synthetic dengue virus envelope protein can be used as a tetravalent vaccine in the prevention of dengue fever, dengue hemorrhagic fever and dengue septic shock. | 2009-08-06 |
20090197321 | STRAIN OF GENETICALLY REENGINEERED ESCHERICHIA COLI FOR BIOSYNTHESIS OF HIGH YIELD CAROTENOIDS AFTER MUTATION SCREENING - The present invention relates to a strain of | 2009-08-06 |
20090197322 | SOLAR PLANT EMPLOYING CULTIVATION OF ORGANISMS - A method of growing algae is described that is part of a cogenerational energy production plant in which solar energy from a solar collecting and concentrating field is used to provide photonic energy for the growth and stress phase of algae as well as to provide heat for driving a turbine. The supplementary energy for the power plant is provided by natural gas and by biomethane that is produced by fermentation of the algal biomass. The carbon dioxide that is a by-product of the combustion of both the natural gas and the biomethane is recycled to provide the carbon source for the algal growth. | 2009-08-06 |
20090197324 | SYSTEMS AND METHODS FOR EX VIVO LUNG CARE - Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas. | 2009-08-06 |
20090197325 | SYSTEMS AND METHODS FOR Ex vivo LUNG CARE - Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas. | 2009-08-06 |
20090197326 | Biological Analysis Arrangement and Approach Therefor - Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample. | 2009-08-06 |
20090197327 | Culturing Bag - A culturing bag for microorganisms has a wall formed of plastic film wherein at least one wall area of the wall is permeable for oxygen and carbon dioxide. A first layer of microporous film is attached to the at least one wall area as an exterior layer so as to form a multi-layer configuration in the at least one wall area. The first layer of microporous film is sealed by a seal-tight edge seam to the wall. The microporous film is adapted to be torn open or torn off. At least one second layer of microporous film can be placed between the exterior layer and the wall. | 2009-08-06 |
20090197328 | Process and apparatus for producing entrapping immobilization pellets - A large amount of entrapping immobilization pellets with highly stable quality are produced inexpensively by high-speed treatment. There is provided a process for producing entrapping immobilization pellets in which microorganisms are entrapped and immobilized in an immobilizing agent, the process comprising polymerizing a mixture containing the microorganisms and a solution of the immobilizing agent in a forming frame into a gel to prepare a pellet block. | 2009-08-06 |
20090197329 | APPARATUS AND METHOD FOR SEPARATING BIOLOGICAL PARTICLES USING DIFFERENCE BETWEEN GRAVITY AND MAGNETIC FORCE - Disclosed is an apparatus and method for injecting liquid-drops of particle mixture liquid including a mixture of biological particles, affecting magnetic field, and having only positive particles, which are combined with magnetic responsive material, separated by magnetic force, and having negative particles, which are not combined with magnetic responsive material, precipitated by gravity. | 2009-08-06 |
20090197330 | ANTI-CD20 MONOCLONAL ANTIBODY - Disclosed is a monoclonal antibody capable of inducing a specific biological reaction through the binding of the monoclonal antibody to a CD20 antigen on the surface of a cell. A monoclonal antibody having a high binding affinity to an extracellular epitope of a CD20 antigen and also having biological activities including a cell growth inhibitory activity is cloned. The monoclonal antibody is chimerized or humanized to develop a therapeutic agent for a disease in which B cells are involved. | 2009-08-06 |
20090197331 | Compositions for cryopreservation of cells - A composition for the cryopreservation of cells according to the present invention at least comprises sericin and one or more components selected from the group consisting of amino acids and saccharides. Further, a method for the cryopreservation of cells according to the present invention comprises the steps of placing target cells in the abovementioned composition for the cryopreservation of cells and cryopreserving them. According to the composition for the cryopreservation of cells of the present invention, cells can be cryopreserved over a long period of time without the use of serum and components derived from serum. | 2009-08-06 |
20090197332 | Modified Short Interfering RNA - The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), the siRNA further comprising at least one overhang at the 5′ and/or 3′ end, wherein the overhang residue or overhang residues are chemically modified and selected independently from each other from the group consisting of: (a) 2′-deoxy modified nucleotides; (b) 2′-methoxy modified nucleotides; (c) two nucleosides linked by a 3′ to 5′ or 2′ to 5′ formacetal linkage; (d) nucleotides modified at the 2′-position by a -0-CH | 2009-08-06 |
20090197333 | METHOD FOR PRODUCTION OF BIOLOGICAL ORGANIC MATERIAL AND CULTURE VESSEL - Disclosed is a method for producing a biological organic material in a liquid droplet comprising a culture medium composed of specified ingredient. The method comprises the steps of: providing a substantially spherical liquid droplet on a substrate in an unadhered state, the substrate preferably having such a water-repellent surface that the water contact angle becomes 150° or greater; and culturing a biological organic material in the liquid droplet. | 2009-08-06 |
20090197334 | METHODS OF CULTURING EMBRYONIC STEM CELLS AND CONTROLLED DIFFERENTIATION - The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or somatic differentiation. Preferably the cells are capable of somatic differentiation in vitro and are inclined to differentiate away from an extraembryonic lineage. The present invention also provides method of culturing embryonic stem (ES) cells to improve stem cell maintenance and persistence in culture. The method also provides a culture of ES cells prepared by the method as well as differentiated cells derived from the embryonic cells resulting from directed differentiation procedures provided by the present invention. | 2009-08-06 |
20090197335 | METHOD FOR IMPROVED TRANSFER OF DNA INTO LIVING CELLS BY ELECTROPORATION - The subject invention concerns an electroporation buffer that allows for enhanced transfection efficiency and cell viability of cells during application of an electric current. Buffers of the invention provide for maximum transfer of target particles into cells while maintaining the health and growth potential of the cell population. Compositions of the invention comprise electroporation buffers of approximately physiological ionic strength and pH, and having serum or purified proteins, such as serum albumin, added thereto. The subject invention is suitable for use with any cell type. The subject invention also concerns methods of electroporation using an electroporation buffer of the invention. | 2009-08-06 |
20090197336 | SUPPRESSION OF POLYMORPHIC ALLELES - Methods and agents for suppressing expression of a mutant allele of a gene having a polymorphism are provided. The methods of the invention provide suppression effectors such as antisense nucleic acids or ribozymes, that bind to nucleic acid regions having a polymorphism within a gene such that one allele of a gene is exclusively or preferentially suppressed. The method also provides the administration of a replacement nucleic acid, if required. The invention has the advantage that the same suppression strategy, when directed to polymorphisms, could be used to suppress, in principle, many mutations in a polymorphic gene. This is particularly relevant when large numbers of mutations within a single gene cause disease pathology. | 2009-08-06 |
20090197337 | Methods for the production of multimeric proteins and related compositions - Improved methods for the production of multimeric-protein-complexes, such as redox proteins and immunoglobins, in association with oil bodies are described. The redox protein is enzymatically active when prepared in association with the oil bodies. Also provided are related nucleic acids, proteins, cells, plants, and compositions. | 2009-08-06 |
20090197338 | Method of Increasing the Function of an AAV Vector - A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences. | 2009-08-06 |
20090197339 | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris - The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as | 2009-08-06 |
20090197340 | Method for Determining the Nutritional Quality of Milk Lipids - A method for determining the nutritional quality of milk lipids, involving the steps consisting in considering a defined number of reference milk samples; determining, for each of said reference samples, a fatty acid profile and an infrared spectrum obtained through reflection on the reference sample of a radiation in the mean infrared and associating respectively the fatty acid profiles to the infrared spectra, subjecting the milk to be analyzed, the lipid nutritional quality is to be determined, to an infrared radiation, so as, through reflection, to infer an infrared spectrum, and comparing the milk infrared spectrum to be analyzed to the infrared spectra of the reference samples, so as to infer a fatty acid profile of the milk to be analyzed. | 2009-08-06 |
20090197341 | WATER SOLUBLE FILM BASED MATRIX TO COLLECT SAMPLES EXTRACTED FROM LIVING SPECIES - The invention relates to a water soluble film based matrix for collecting blood samples, urine samples, serum samples or any other type of samples extracted from living species; so as to avoid cross infection or spillage of samples during transportation of said samples. These samples can then used for further detection of virus, bacteria, finding new molecules, diagnosing genes or extraction of DNA. Also, said matrix will dissolve during analysis of the sample and thus there will be no disposal problems. | 2009-08-06 |
20090197342 | Marker for Inflammatory Conditions - Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. | 2009-08-06 |
20090197343 | METHODS FOR DETECTION OF PATHOGENIC PRION PROTEINS ASSOCIATED WITH PRION DISEASES, USING CONJUGATED POLYELECTROLYTES - The present invention relates to a method for detecting the presence of a pathogenic prion species in a sample comprising the steps—bringing the sample in contact with at least one conjugated polyelectrolyte (CPE)—irradiating the CPE with electromagnetic radiation—measuring the radiation emitted or absorbed by the CPE at at least one wavelength, and—comparing the measured emitted or absorbed radiation to at least one reference value corresponding to the CPE interacting with a known prion species. Optionally, the emitted or absorbed radiation is measured at least two wavelengths and a ratio is formed of the values of the measured radiation. The method facilitates differentiation between different strains of pathogenic prion species. The invention also relates to devices for performing the method. | 2009-08-06 |
20090197344 | METHOD FOR THE PREDICTION OF VASCULAR EVENTS AND THE DIAGNOSIS OF ACUTE CORONARY SYNDROME - The present invention relates to a method for the prognosis of a vascular event or the diagnosis of ACS in a patient suspected of being at risk for a vascular event or condition, said patient presenting:
| 2009-08-06 |
20090197345 | METHOD FOR QUANTIFICATION OF ALLERGENS - The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard peptide(s) having a sequence of amino acids which is identical with, and optionally unique for, a sequence to be found in the allergen to be quantified and optionally labelling said allergen calibration standard peptide(s), b) degrading the allergen sample to obtain a mixture of peptides, and optionally labelling said peptides with one or more labelling agent(s), wherein at least the peptides in the degraded allergen sample or the calibration standard peptides are labelled, and if both the peptides in the degraded allergen sample and the allergen calibration standard peptide(s) are labelled, the labelling agent(s) used for labelling the allergen calibration standard peptide(s) are different from the labelling agent(s) used for labelling the peptides of the degraded allergen sample, c) quantifying the absolute amount of allergen by correlating the amount of the allergen calibration standard peptide(s) with the amount of the corresponding peptide(s) of the degraded allergen sample by mass analysis. | 2009-08-06 |
20090197346 | COMPOSITIONS AND METHODS FOR PRESERVING RNA IN BIOLOGICAL SAMPLES - The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples. | 2009-08-06 |
20090197347 | IMMUNOASSAY FOR PLASMODIUM FALCIPARUM AND ASSAY DEVICE USED THEREFOR - Disclosed are an immunoassay of | 2009-08-06 |
20090197348 | PYROCATECHOL VIOLET-METAL PROTEIN ASSAY - A method for protein determination utilizing a pyrocatechol violet-metal complex, a composition used in the protein determination assay, and a kit. | 2009-08-06 |
20090197349 | ELECTROCHEMILUMINESCENCE OF RARE EARTH METAL CHELATES - Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures. | 2009-08-06 |
20090197350 | MAGNETIC MEMORY DEVICE AND METHOD - An exemplary embodiment of a magnetic random access memory (MRAM) device includes a magnetic tunnel junction having a free layer, a first electrode (first magnetic field generating means) having a first portion that covers a surface of the free layer, and an electric power source connected to the first electrode via a connection that covers less than half of the first portion of the first electrode. Another exemplary embodiment of an MRAM device includes a magnetic tunnel junction, first and second electrodes (first and second magnetic field generating means) directly connected to the magnetic tunnel junction on opposite sides of the magnetic tunnel junction, and an electric power source having one pole connected to the first electrode via a first connection and having a second pole connected to the second electrode via a second connection, wherein the first and second connections are laterally offset from the connections between the first and second electrodes and the magnetic tunnel junction. Methods of operating and manufacturing these magnetic random access memories are also disclosed. | 2009-08-06 |
20090197351 | LASER PROCESSING METHOD - In a laser beam processing method, when a laser beam is emitted along a second predetermined dividing line to form a second groove intersecting a first groove previously formed, the power output of the laser beam is allowed to be a first power output in a first interval, that is, until the second predetermined dividing line reaches a position immediately before the first groove. In a second interval from the position close to the first groove to the first groove reached by the second predetermined dividing line, the power output of the laser beam is set to a second power output lower than the first power output. Thus, overheat on the periphery of the second interval can be suppressed. | 2009-08-06 |
20090197352 | Substrate processing method and film forming method - A substrate processing method in a processing chamber, has: accommodating a substrate into a processing chamber; and processing the substrate in the processing chamber on the basis of a correlation of a preset temperature of a heating device, a flow rate of fluid supplied by a cooling device and a temperature deviation between the center side of the substrate accommodated in the processing chamber and the outer peripheral side of the substrate while the substrate accommodated in the processing chamber is optically heated from an outer periphery side of the substrate at a corrected preset temperature by the heating device and the fluid is supplied to the outside of the processing chamber at the flow rate based on the correlation concerned to cool the outer peripheral side of the substrate by the cooling device. | 2009-08-06 |
20090197353 | METHOD OF MANUFACTURING MATERIAL TO BE ETCHED - A method is provided, of manufacturing a material to be etched that can more preferably prevent a region to be etched from remaining as an un-etched region and reduce deviation of etched/un-etched regions. | 2009-08-06 |
20090197354 | SYSTEM AND METHOD FOR MONITORING MANUFACTURING PROCESS - A system and method for monitoring a manufacturing process are provided. A wafer is provided. Process parameters of a manufacturing machine are in-situ measured and recorded if the wafer is processed in the manufacturing machine. A wafer measured value of the wafer is measured after the wafer has been processed. The process parameters are transformed into a process summary value. A two dimensional orthogonal chart with a first axis representing the wafer measured value and a second axis representing the process summary value is provided. The two dimensional orthogonal chart includes a close-loop control limit. A visualized point representing the wafer measured value and the process summary value is displayed on the two dimensional orthogonal chart. | 2009-08-06 |
20090197355 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE AND SEMICONDUCTOR DEVICE MANUFACTURING SYSTEM - A method for manufacturing a semiconductor device that controls the influence of a thickness of a stopper film even if there is a change in the thickness of the stopper film by measuring the thickness prior to etching to a predetermined thickness. | 2009-08-06 |
20090197356 | Substrate positioning on a vacuum chuck - We have discovered a method of using the vacuum chuck/heater upon which a substrate wafer is positioned to determine whether the wafer is properly placed on the vacuum chuck. The method employs measurement of a rate of increase in pressure in a confined space beneath the substrate. Because the substrate is not hermetically sealed to the upper surface of the vacuum chuck/heater apparatus, pressure from the processing chamber above the substrate surface tends to leak around the edges of the substrate and into the space beneath the substrate which is at a lower pressure. A pressure sensing device, such as a pressure transducer is in communication with a confined volume present beneath the substrate. The rate of pressure increase in the confined volume is measured. If the substrate is well positioned on the vacuum chuck/heater apparatus, the rate of pressure increase in the confined volume beneath the substrate is slow. If the substrate is not well positioned on the vacuum chuck/heater apparatus, the rate of pressure increase is more rapid. | 2009-08-06 |
20090197357 | HIGH-TEMPERATURE ION IMPLANTATION APPARATUS AND METHODS OF FABRICATING SEMICONDUCTOR DEVICES USING HIGH-TEMPERATURE ION IMPLANTATION - A semiconductor device fabrication apparatus includes a load lock chamber, a loading assembly in the load lock chamber, and an ion implantation target chamber that is hermetically connected to the load lock chamber. The load lock chamber is configured to store a plurality of wafer plates. Each wafer plate respectively includes at least one semiconductor wafer thereon. The ion implantation target chamber is configured to implant an ion species into a semiconductor wafer on a currently loaded wafer plate. The loading assembly is also configured to load a next one of the plurality of wafer plates from the load lock chamber into the ion implantation target chamber. The loading assembly may be configured to load the next wafer plate from the load lock chamber into the ion implantation target chamber while substantially maintaining a current temperature within the ion implantation target chamber and/or without depressurizing the ion implantation target chamber. Related methods and devices are also discussed. | 2009-08-06 |
20090197358 | Method for making COP evaluation on single-crystal silicon wafer - An evaluation area of an evaluation object wafer is concentrically divided in a radial direction, an upper limit value to the number of COPs is set in each divided evaluation segment, and an acceptance determination of the single-crystal silicon wafer is made using the upper limit value as a criterion. Thereby, a quantitative and objective COP evaluation can be made, and a proper determination is made based on a clear criterion. The evaluation method of the present invention can sufficiently deal with automation of the COP evaluation (inspection) and the higher-quality wafer in the near future, and the evaluation method can be widely applied to production of the single-crystal silicon wafer and production of a semiconductor device. | 2009-08-06 |
20090197359 | METHODS FOR EVALUATING AND MANUFACTURING SEMICONDUCTOR WAFER - A method for evaluating a shape change of a semiconductor wafer is provided. The method comprises acquiring unconstrained shape data of shape data of the semiconductor wafer being placed on a reference surface in a unconstrained state; acquiring constrained shape data of shape data of the semiconductor wafer being constrained along the reference surface in a constrained state; and comparing the unconstrained shape data and the constrained shape data. A method for manufacturing the semiconductor wafer utilizing a result of the evaluation of the wafer is also provided. | 2009-08-06 |
20090197360 | LIGHT EMITTING DIODE PACKAGE AND FABRICATION METHOD THEREOF - An LED package and a fabrication method therefor. The LED package includes first and second lead frames made of heat and electric conductors, each of the lead frames comprising a planar base and extensions extending in opposed directions and upward directions from the base. The package also includes a package body made of a resin and configured to surround the extensions of the first and second lead frames to fix the first and second lead frames while exposing underside surfaces of the first and second lead frames. The LED package further includes a light emitting diode chip disposed on an upper surface of the base of the first lead frame and electrically connected to the bases of the first and second lead frames, and a transparent encapsulant for encapsulating the light emitting diode chip. | 2009-08-06 |
20090197361 | Method for Producing an LED Light Source Comprising a Luminescence Conversion Element - The invention describes a method for producing a light-emitting-diode (LED) light source, particularly comprising mixed-color LEDs, wherein at least a portion of primary radiation emitted by a chip is transformed by luminescence conversion. Said chip comprises a front-side (i.e., the side facing in the direction of radiation) electrical contact to whose surface a luminescence conversion material is applied in the form of a thin layer. Prior to coating, the front-side electrical contact is raised by the application of an electrically conductive material to the electrical contact surface. The method enables specific color coordinates to be adjusted selectively by monitoring the color coordinates (IEC chromaticity diagram) and thinning the layer of luminescence conversion material. In addition, the method is suited in particular for simultaneously producing a plurality of LED light sources from a multiplicity of similar chips in a wafer composite. | 2009-08-06 |