29th week of 2009 patent applcation highlights part 17 |
Patent application number | Title | Published |
20090181367 | Diagnosis of sepsis using mitochondrial nucleic acid assays - The invention provides assays to detect sepsis disease states in a subject by determining the relative amount of mitochondrial nucleic acid in the subject. The assays of the invention may include PCR assays, such semi-quantitative or quantitative PCR involving the co-amplification of a mitochondrial sequence and a reference sequence, such as a genomic sequence. Information from such assays may be evaluated to provide a ratio of mitochondrial nucleic acid to nuclear nucleic add in the cells of the subject. | 2009-07-16 |
20090181368 | METHOD OF DETECTING MYCOPLASMA - An object of the present invention is to provide a primer capable of detecting a mycoplasma | 2009-07-16 |
20090181369 | Methods for the Treatment of Disease - The present invention is directed to methods to determine the likelihood of therapeutic effectiveness of a farnesyl transferase inhibitor (FTI). The method comprises determining whether the gene encoding the farnesyl transferase beta subunit (FNTB) of said patient comprises at least one nucleic acid variance that causes an alteration in an amino acid residue. The change in the amino acid residue is associated with resistance to a FTI. The absence of at least one variance indicates that the FTI is likely to be effective. | 2009-07-16 |
20090181370 | Method for Sequencing a Polynucleotide Template - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other. | 2009-07-16 |
20090181371 | METHODS AND COMPOSITIONS RELATED TO A BRAF MUTATION AND MICROSATELLITE STABILITY - Disclosed are methods and compositions related to a BRAF mutation and microsatellite stability. | 2009-07-16 |
20090181372 | Method and compositions for monitoring DNA binding molecules in living cells - The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that the nucleic acid can be directly detected when bound by fluorescently labeled compound; and directly detecting the location of fluorescence within the cell, fluorescence aggregated at the site of the nucleic acid array indicating a compound that binds to the selected nucleic acid. In particular compounds such a transcription factors can be screened. Reagents for such method are provided including a mammalian cell having a plurality of steroid receptor response elements in an array such that the response element can be directly detected when bound by fluorescently labeled steroid receptor and a chimeric protein comprising a fluorescent protein fused to a steroid receptor. | 2009-07-16 |
20090181383 | Cancer Risk Biomarker - The present disclosure relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer. Also provided are methods and compositions for identifying a greater risk for a cancer-related condition in an subject. | 2009-07-16 |
20090181384 | Prognosis prediction for colorectal cancer - This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer, based on signatures of genetic markers. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a treatment modality for a cancer patient, among other methods as well as kits and devices for carrying out these methods. | 2009-07-16 |
20090181385 | Reagents, methods, and libraries for bead-based sequencing - The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to immobilized beads. The invention further provides sets of labeled probes containing phosphorothiolate linkages. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. | 2009-07-16 |
20090181386 | Calving Characteristics - The invention relates to a method for determining calving characteristics in bovine subjects, wherein calving characteristics comprise stillbirth, calving difficulty and calf size at birth, which are all economically important factors. In particular, the method of the invention involves identification of genetic markers and/or Quantitative Trait Locus (QTL) for the determination of calving characteristics in a bovine subject. The determination of calving characteristics involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with calving characteristics. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with calving characteristics that will yield cows less prone to stillbirth, calving difficulties and undesired calf size at birth. | 2009-07-16 |
20090181387 | Method for Analysing Nucleic Acids - Method of analyzing nucleic acids comprising the steps of nucleic acid fractionation, adaptor binding and nucleic acid amplification, and an in vitro transcription step. The invention has application in the field of genomic analysis of organisms by the use of DNA microarrays. | 2009-07-16 |
20090181388 | Enclosed unit for rapid detection of a target nucleic acid amplification product - The invention relates to a method for rapid detection of a target nucleic acid amplification product while preventing cross-contamination between target nucleic acid amplification products and avoiding false positives, comprising the steps of: a) leaving the reaction tube unopened after the amplification reaction is finished, so as to prevent the target nucleic acid amplification product from leaking out and resulting in contamination; b) placing the unopened reaction tube inside an enclosed unit, making the target nucleic acid amplification product be transferred to a test strip from the reaction tube in a physically enclosed environment; c) performing detection in a visual read-out manner, and determining the result; d) discarding the enclosed unit in a safety place as a whole without opening it after the detection. The invention also relates to a totally enclosed unit for detecting a target nucleic acid amplification product, and still relates to applications of the totally enclosed rapid detection unit in detection of infectious pathogens, food industry, agriculture, livestock husbandry, customs quarantine control, and determination of DNA. | 2009-07-16 |
20090181389 | QUANTITATIVE MEASUREMENT OF NUCLEIC ACID VIA LIGATION-BASED LINEAR AMPLIFICATION - Methods, compositions and kits are provided for sensitive and quantitative detection of nucleic acid, especially for the determination of the presence and/or amount of a target nucleic acid with mutations or single nucleotide polymorphism (SNP). In particular, assays are provided for amplifying a target nucleic acid via ligation of designed oligonucleotide probes and linear amplification by using an RNA polymerase, such as T7 polymerase. The assays can be used for diagnosis, prognosis or monitoring of diseases or disorders, for pharmacogenomic studies of patient stratification and drug responses, for discovery of therapeutic targets, or for forensic analysis. | 2009-07-16 |
20090181390 | HIGH THROUGHPUT DETECTION OF MICRORNAS AND USE FOR DISEASE DIAGNOSIS - Methods, compositions and kits are provided for high throughput detection of micro RNAs (miRNA), especially for sensitive and specific detection of miRNA that are in low abundance and closely related to each other. In particular, an assembly of designed oligonucleotide probes with unique tag sequences is used to achieve these purposes via high throughput microarrays, optionally in conjunction with branched-DNA based array detection. The assays can be used for diagnosis, prognosis or monitoring of diseases or disorders such as cancer, for pharmacogenomic studies of patient stratification and drug responses, for discovery of therapeutic targets, or for forensic analysis. | 2009-07-16 |
20090181391 | METHODS FOR ANALYSIS OF DNA METHYLATION PERCENTAGE - Methods are disclosed for determining the methylation state of DNA samples using melt analysis including high resolution melt analysis. Methods are also provided for determining methyltransferase activity using melt analysis including high resolution melt analysis. Additionally, kits of parts are provided. | 2009-07-16 |
20090181392 | Transgenic Zebrafish Models for Neurodegenerative Diseases - The present invention relates to zebrafish models for neurodegenerative disorders that allow screening of compounds for their ability to protect and/or regenerate neurons in vivo in a whole vertebrate organism. The present invention also provides methods of identifying gene targets for neuroprotective compounds, compounds that regenerate neurons and compounds that promote neurogenesis. | 2009-07-16 |
20090181393 | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy - The present invention is directed to the identification of markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with responsiveness or non-responsiveness to a therapeutic regimen comprising proteasome inhibition. Thus, by examining the expression levels of individual markers and those comprising a marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of tumors in a clinical setting. | 2009-07-16 |
20090181394 | Diagnostic methods and kits for hepatocellular carcinoma using comparative genomic hybridization - The invention provides diagnostic methods for determining the prognosis of hepatocellular carcinoma (HCC) comprising the steps of (a) observing recurrently altered genomic region on a chromosome; (b) measuring variation of one or more of RAR expression variations selected from the RAR variation group consists of gains of RAR-G1 to RAR-G14 and losses of RAR-L1 to RAR-L18 as defined in table 1, a diagnostic kit, and genes for useful in diagnosis or prognosis of liver cancer. | 2009-07-16 |
20090181395 | DETECTION OF ANTIBIOTIC-RESISTANT MICROORGANISMS - Method of detecting methicillin-resistant | 2009-07-16 |
20090181396 | METHODS AND SYSTEMS FOR ANALYSIS OF FLUORESCENT REACTIONS WITH MODULATED EXCITATION - Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom. | 2009-07-16 |
20090181397 | PREDICTIVE AND DIAGNOSTIC METHODS FOR CANCER - The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of the disease and methods of reversing the prostate cell transformation based on the presence or absence in the human subject of a dinucleotide (TT) deletion in the gene encoding the U50 snoRNA. Provided, therefore, are methods of identifying a genetic marker of a human subject indicating a cancerous tissue in the human subject, embodiments of the methods comprising: determining from an isolated nucleic acid sample the genotype of the human subject with respect to a locus encoding a snoRNA U50, where a mutation within the nucleotide sequence encoding a snoRNA U50, when compared with a wild-type nucleotide sequence encoding a snoRNA U50, identifies in the human subject a genetic marker associated with a cancer in the human subject. The cancer may be, but is not necessarily limited to, a prostate cancer or a breast cancer. | 2009-07-16 |
20090181398 | Nanoparticle conjugates - Conjugate compositions are disclosed that include a specific-binding moiety covalently coupled to a nanoparticle through a heterobifunctional polyalkyleneglycol linker. In one embodiment, a conjugates is provided that includes a specific-binding moiety and a fluorescent nanoparticle coupled by a heterobifunctional PEG linker. Fluorescent conjugates according to the disclosure can provide exceptionally intense and stable signals for immunohistochemical and in situ hybridization assays on tissue sections and cytology samples, and enable multiplexing of such assays. | 2009-07-16 |
20090181399 | INSECT RESISTANT COTON PLANTS AND METHODS OF DETECTING THE SAME - The present application relates to an insect resistant transgenic cotton event designated COT202. The application also relates to polynucleotides which are characteristic of the COT202 event, plants comprising said polynucleotides, and methods of detecting the COT202 event. | 2009-07-16 |
20090181400 | Method of Detection of Prostate Cancer - The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma. | 2009-07-16 |
20090181401 | Detection format for hot start real time polymerase chain reaction - The present invention is directed to a method and a composition for amplifying and detecting a target nucleic comprising subjecting said target nucleic acid to a real time PCR amplification reaction in the presence of a thermostable DNA polymerase, a thermostable double strand dependent 3′-5′ exonuclease having a temperature optimum above 37° C., a pair of amplification primers, deoxynucleoside triphosphates, a detecting oligonucleotide carrying a first label and a second label, said first label being capable of acting as a fluorescent reporter entity when excited with light of an appropriate wavelength, said second label being capable of acting as a fluorescence quenching entity of said fluorescent reporter entity, characterized in that one label is bound to the 3′ end of said detecting oligonucleotide, and further characterized in that the other label is bound either internally or at the 5′ end of said detecting oligonucleotide, and monitoring fluorescence of said fluorescent reporter entity at least after a plurality of amplification cycles. | 2009-07-16 |
20090181402 | COMPOSITIONS AND METHODS FOR COUPLING A PLURALITY OF COMPOUNDS TO A SCAFFOLD - Compositions and methods are provided for coupling a plurality of compounds to a scaffold. Compositions and methods are further provided for catalyzing a reaction between at least one terminal alkyne moiety and at least one azide moiety, wherein one moiety is attached to the compound and the other moiety is attached to the scaffold, forming at least one triazole thereby. | 2009-07-16 |
20090181413 | SIMULTANEOUS AND DIFFERENTIAL QUANTIFICATION OF TWO TARGET ANALYTES IN BIOLOGICAL SAMPLE - This invention provides a method for differentially and simultaneously quantifying two target analytes via a single assay operation with the use of a single type of reagent in each of the two steps, i.e., the first step and the second step. In this method, the reaction product associated with the first target analyte is detected at an early stage of the second step and the reaction product associated with the second target analyte is then detected. | 2009-07-16 |
20090181414 | RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE - This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery. | 2009-07-16 |
20090181415 | PREDICTION OF GENOTOXICITY - The likelihood that a compound will exhibit genotoxicity in a micronucleus test is predicted by the ability of the compound to inhibit a plurality of kinases from a selected group. | 2009-07-16 |
20090181416 | Enzyme Detection Technique - A diagnostic test kit for detecting the presence or absence of an enzyme (e.g., leukocyte esterase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the enzyme to release a nucleophilic aromatic compound. The kit also comprises a lateral flow device that comprises a chromatographic medium. The chromatographic medium defines a detection zone within which is contained a first reagent (e.g., diazonium ion) that is capable of reacting with the nucleophilic aromatic compound to form a second reagent (e.g., aromatic azo compound). The second reagent exhibits a color that is different than the color of the first reagent. The lateral flow device also includes an absorbent material located adjacent to the chromatographic medium, the absorbent material receiving the test sample after flowing through the chromatographic medium. | 2009-07-16 |
20090181417 | COLORIMETRIC MEASUREMENT OF ENZYMATIC ACTIVITY IN CELL LYSATES - The present invention concerns a method for the calorimetric measurement of enzyme activity comprising the following steps: preparing a cell suspension or a cell lysate containing cell components, adding a chromogenic substrate at the start of the enzyme reaction, adding a first additional substance to stop the enzyme reaction, and making a colorimetric measurement, wherein a second additional substance which reduces the light scattering and/or absorption caused by the cells or the cell components is added during or after termination of the enzyme reaction. | 2009-07-16 |
20090181418 | PEPTIDE ABLE TO BREAK THE M-P53/P63, M-P53/P73 AND M-P53/RESPECTIVE ISOFORM PROTEINS COMPLEX FORMED IN THE TUMOR CELLS AND USES THEREOF IN THE PHARMACOLOGICAL FIELD - The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that has formed in the nucleus of tumor cells. Furthermore, the present invention relates to a method for causing the breakage of said proteinic complexes existing in the tumor cell lines in vitro. The present invention further relates to the use of said peptides for the preparation of a pharmaceutical composition for treating human tumors. | 2009-07-16 |
20090181419 | Method for Quantitatively Determining the Apolipoprotein AI Content in the HDL 2B Subfraction of HDL Cholesterol Subfractions - The invention provides a method (e.g., a computer algorithm) for calculating a number of particles in a HDL subfraction. The method features the steps of: 1) measuring an initial distribution of HDL particles (e.g., a relative mass distribution) from a blood sample; 2) processing the initial distribution of HDL particles with a mathematical model to determine a modified distribution of HDL particles (e.g., a relative particle distribution); 3) determining a total apo-AI content value from a blood sample; and 4) analyzing both the modified distribution of particles and the total apo-AI content value to calculate the apo-AI content value in an HDL subfraction. | 2009-07-16 |
20090181420 | Inhibiting Smad signaling promotes neuron regeneration - Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon. | 2009-07-16 |
20090181421 | DIAGNOSIS OF FETAL ABNORMALITIES USING NUCLEATED RED BLOOD CELLS - The present invention relates to methods for diagnosing a condition in a fetus by enriching and enumerating circulating red blood cells with the possible combination of results from maternal serum marker screens. | 2009-07-16 |
20090181422 | METHOD AND APPARATUS FOR PRODUCING HISTOLOGICAL SECTIONS WITH A MICROTOME - A method and apparatus for producing histological sections by means of a microtome are suggested. A histological section of predefined thickness is produced with a microtome from a block comprising a tissue sample. A carrier material is applied with an application apparatus onto the block prior to before production of the histological section. To ensure that the histological sections do not roll up, and to enable improved downline processing of the histological sections as compared with a carrier material embodied in the form of an endless strip and that the carrier material is cut out prior to application to a size and/or a shape that corresponds substantially to the cross-sectional area of the block; and that the cut-out carrier material is then applied onto the block. The suggested apparatus is designed to apply the carrier material onto a histological section to be prepared by a microtome. | 2009-07-16 |
20090181423 | SUBSTANTIALLY ANIMAL PROTEIN-FREE RECOMBINANT FURIN AND METHODS FOR PRODUCING SAME - The present invention relates to recombinant furin (rFurin) and methods for producing rFurin. More specifically, the invention relates to substantially animal protein-free rFurin and methods for producing substantially animal protein-free rFurin. | 2009-07-16 |
20090181424 | Mammalian Expression Vector Comprising the MCMV Promoter and First Intron of HCMV Major Immediate Early Gene - A mammalian expression vector that is a murine CMV promoter and the first intron of the major immediate early gene of the human cytomegalovirus. There are mammalian host cells containing the expression vector. There is also a process for the production of recombinant protein by using the expression vector. | 2009-07-16 |
20090181425 | Library of Translational Fusion Partners for Producing Recombinant Proteins and Translational Fusion Partners Screened Therefrom - The invention relates to techniques for the rapid screening of suitable translational fusion partners (TFPs) capable of inducing secretory production of recombinant proteins, especially proteins that are difficult to produce using conventional recombinant production methods. | 2009-07-16 |
20090181426 | Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants - The invention relates to cell culture methods, kits and cell lines for producing recombinant products, e.g. therapeutic proteins and antibodies, in the presence of reduced levels of one or more contaminants and further to methods of purifying those products. | 2009-07-16 |
20090181427 | HYBRID 3' UNTRANSLATED REGIONS SUITABLE FOR EFFICIENT PROTEIN EXPRESSION IN MAMMALIAN CELLS - The present invention describes the use of hybrid short 3′ untranslated (3′UTR) regions which are composed of two regions, one region from an 3′ untranslated region of a stable eukaryotic mRNA, and another region from the downstream end of an 3′ untranslated region of another eukaryotic mRNA that contains a polyadenylation (polyA) signal. The use of such hybrid regions allows for an efficient protein expression when used in conjunction with circular or linear expression DNA molecules. The present invention provides a recombinant DNA that is composed of a promoter, a protein coding region, and the hybrid 3′UTR in a continuous and directional orientation. The efficient expression systems of the invention are suitable for the economical and efficient production of therapeutic proteins and for use with both transient and stable expression systems. | 2009-07-16 |
20090181428 | METHOD FOR PRODUCING TARGET PROTEINS USING AMINO ACIDS AND PYRUVIC ACIDS IN CULTURE OF PLANT CELLS - Provided is a method for producing a target protein via cultivation of transgenic plant cells comprising a promoter capable of expressing the protein under sugar-free conditions or in response to the depletion of sugar and a gene encoding the target protein, without exchange of a cell growth medium with a sugar-depleted medium. The method comprises 1) culturing transgenic plant cells in a sugar-rich medium to grow plant cells; and 2) culturing the transgenic plant cells with addition of an amino acid mixture to the culture of Step 1 without exchange of a cell growth medium with a sugar-depleted medium, thereby expressing a target protein. The method of the present invention enables commercial-scale production of recombinant proteins via establishment of optimized culture conditions by addition of an amino acid mixture to induce protein expression without exchange of a cell growth medium with a sugar-free medium, and addition of pyruvic acid during the induction period of protein expression to thereby enhance the production yield of target proteins. | 2009-07-16 |
20090181429 | Systems for the Expression of Orthogonal Translation Components Eubacterial Host Cells - The invention relates to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural amino acids at genetically-programmed positions. | 2009-07-16 |
20090181430 | PROTEIN FOLDING - The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight sulfhydryl/disulfide redox system. The solution is then incubated under conditions suitable for generating dimeric biologically active Transforming Growth Factor Beta. | 2009-07-16 |
20090181431 | Fusion Proteins Between Plant Cell-Wall Degrading Enzymes, and Their Uses - The invention relates to the use of fusion proteins between at least two plant cell-wall degrading enzymes, the enzymes being such that they do not contain a C-terminal carbohydrate-binding-molecule (CBM), and optionally a CBM, the enzymes and CBM being recombinant proteins corresponding to native proteins in fungi, or mutated forms thereof, for carrying out processes of plant cell-wall degradation in the frame of the preparation, from plants or vegetal by-products, of compounds of interest located in plant cell-wall, or in the frame of the bleaching of pulp and paper. | 2009-07-16 |
20090181432 | PROCESS FOR SELF-ASSEMBLY OF STRUCTURES IN A LIQUID - A process and apparatus for DNA sequencing is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of recognition chambers in which a species of recognition element nucleotides are differentially added and subjected to a polymerization reaction allows recognition of which species is next in sequence on a template strand as measured by a detector in a detection area. The position in the sequence is then completed by addition of a saturating amount of building element to complete the polymerization reaction on all structure strands. The process is repeated until the sequence is identified. | 2009-07-16 |
20090181443 | IDENTIFICATION, CLONING, EXPRESSION, AND A PURIFICATION OF THREE NOVEL HUMAN CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 FAMILY MEMBERS POSSESSING TRIACYLGLYCEROL LIPASE AND ACYLGLYCEROL TRANSACYLASE ACTIVITIES - Isolated novel and purified and characterized phospholipase A | 2009-07-16 |
20090181444 | MODIFIED CARBOHYDRATE PROCESSING ENZYME - A modified polypeptide having carbohydrate processing enzymatic activity is provided, said polypeptide comprising an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO:2 comprising a mutation in at least one of W433, E432 and M439; (b) the amino acid sequence of an enzyme of glycosyl hydrolase family 1, comprising at least one mutation at an amino acid residue equivalent to W433, E432 or M439 of SEQ ID NO:2; and (c) a variant of (a) or (b) having carbohydrate processing enzymatic activity and comprising at least one amino acid mutation at a position equivalent to W433, E432 or M439 of SEQ ID NO:2. | 2009-07-16 |
20090181445 | Crystallization and Structure of a Plant Peptide Deformylase - This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide. | 2009-07-16 |
20090181446 | METHOD FOR PROPAGATING INFLUENZA VIRUS - A method for producing influenza virus on large scale is provided. A method for propagating influenza virus which comprises, after removing or decreasing a trypsin inhibitor secreted into culture of MDCK cells (cell line derived from dog kidney) by washing with a culture medium or a buffer, inoculating influenza virus into said cells and culturing said influenza virus-inoculated cells in a culture medium supplemented with trypsin. | 2009-07-16 |
20090181447 | Grass endophytes - The present invention relates to a combination of a | 2009-07-16 |
20090181448 | PERFUSION TYPE VASCULAR TISSUE BIOREACTOR WITH ROTARY AND STRETCHING FUNCTIONS - The present invention in one aspect provides a bioreactor for vascular construct that comprises a pulse-generating device with simple structure and reliable and stable pulse-generating operation. In another aspect, the present invention provides bioreactor for vascular construct that implements rotation of vascular construct and culture chamber, axial stretching of vascular construct, and duplicating pulsatile flow. | 2009-07-16 |
20090181449 | DEVICE AND METHOD FOR AUTOMATING MICROBIOLOGY PROCESSES - A device and method for automating the handling and testing of microbiological specimens are provided. A portable specimen collection vehicle (SCV) is provided which comprises a protective housing, a specimen chamber for receiving a biospecimen sample, a plurality of culturing chambers each for receiving a portion of the biospecimen sample and each containing a different culture medium, a system of fluid ducts connecting the specimen chamber to each of the culturing chambers, and an actuator that facilitates flow of portions of the biospecimen sample from the specimen chamber through the system of fluid ducts and into each of the culturing chambers, wherein biological organisms in the biospecimen begin to grow in one or more of the culturing chambers and cultured portions of the biospecimen sample can be withdrawn selectively from the apparatus. A microbiology automation platform includes a computer system that integrates microbiology laboratory instruments and workflow logic in order to perform organism detection and susceptibilities on specimens contained in an SCV. The platform is intended to automate the work of a medical technologist which is characteristically labor intensive. The work performed by the platform includes accession of the specimen, pre-test processes, detection and susceptibility assays, post-test handling and reporting of results. | 2009-07-16 |
20090181450 | Metod and unit for preparing a sample for the microbiological analysis of a liquid - The preparation unit comprises a body ( | 2009-07-16 |
20090181451 | SPECIMEN SAMPLE COLLECTION DEVICE AND TEST SYSTEM - A specimen sample collection device and test system includes a handle having a sufficiency indicator, an absorbent pad partially contained within said handle, a pad compression tube insertable over said absorbent pad within said handle and around an end of said handle, and a collection tube having one or more sample chambers, attachable to said pad compression tube, and wherein said compression tube defines one or more chambers, and wherein when said collection tube is attached to said pad compression tube, the chambers are in fluid communication with said pad compression tube. A specimen sample collection device including a sufficiency indicator made up of a light pipe indicator window. A specimen sample collection device including an absorbent pad split and divided into two lengths connected at a base. A specimen sample collection device including a bar code identification. A specimen sample collection device and test system including a locking mechanism. A specimen sample collection device including a handle having one or more analyte test strips therein. A specimen sample collection device and test system including a reader. | 2009-07-16 |
20090181452 | Cell Culture and Mixing Vessel - A mixing vessel ( | 2009-07-16 |
20090181463 | DEVICE AND METHOD FOR CHEMICAL, BIOCHEMICAL, BIOLOGICAL AND PHYSICAL ANALYSIS, RE-ACTION, ASSAY AND MORE - The invention is directed to a device and a method for carrying out experiments of chemical, biochemical, biological and physical analysis, reaction and assay employing a reaction unit, in a preferred embodiment comprising: a capillarity reaction chamber, non-capillarity zone and bottom structure, which can use capillary action to quantitatively take up by itself and hold liquid in the reaction chamber. A multi-unit plate, which contains a number of reaction units on a plate frame, can be used for parallel experiments in conjunction with reservoir plate, waster pad, and liquid transfer guider. | 2009-07-16 |
20090181464 | ACCURATE MAGNETIC BIOSENSOR - A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a specified threshold level. In an alternative embodiment, a displacement step is used as soon as the signal has reached a pre-defined threshold level. | 2009-07-16 |
20090181465 | Method For Measuring Volatile Organic Compounds And A Kit For Same - A method for measuring volatile organic compounds (VOCs) of a material produced in a process system is disclosed. The method involves an enclosed bag into which a sample of material is placed, after which the bag is stored at a predetermined temperature such that the contents reach equilibrium. The storage temperature is the mean exit temperature of the effluent from the process system for which a VOC measurement is required. Samples from the headspace in the bag are inputted into a flame ionization detector to provide the VOC level. A kit for using the method is also disclosed. | 2009-07-16 |
20090181466 | INDICATOR GRANULAR MATERIAL - The present invention relates to indicator granular material, especially for a cat lavatory, in which at least one first granular material is substantially completely coated with a first polymer layer, which is solid at a first pH and is dissolved at a second pH; and also to a cat lavatory and the use of the indicator granular material in a cat lavatory. | 2009-07-16 |
20090181467 | Method of assessing and of activating the alternative cellular energy (ACE) pathway in the therapy of diseases - Alternative cellular energy pigments (ACE-pigments) provide a source of cellular energy other than that provided through the oxidative metabolism of foods, or in the case of plants and certain bacteria, through the process of photosynthesis. In some patients, ACE pigments exist in a form that can be further energized or activated using ultraviolet (UV) light, especially if the reaction is initially triggered by the presence of suitable dyes, such as neutral red. A method is described to assess the energy status of the ACE pathway in an individual or animal and also a method that involves the use of UV light in conjunction with a suitable dye, for activating the pathway in those individuals or animals in which the pathway is not fully charged. Kits for these purposes are also described. | 2009-07-16 |
20090181468 | Methods and compositions for treating cellular proliferative diseases - The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders. | 2009-07-16 |
20090181469 | METHOD OF ENHANCING SIGNAL DETECTION OF CELL-WALL COMPONENTS OF CELLS - The invention relates to methods of enhancing signal detection of components of cell walls, wherein the methods involve lysing cells to form cell-wall fragments and analyzing the cell-wall fragments. | 2009-07-16 |
20090181470 | MEASUREMENT KIT AND AN IMMUNOCHROMATOGRAPHY METHOD - It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions. | 2009-07-16 |
20090181471 | ASSAY DEVICE AND PROCESS FOR THE TESTING OF FLUID SAMPLES - An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the front face of the backing and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then flows upwardly through the test strip to react with reagents within the test strip. | 2009-07-16 |
20090181472 | LABELED MOLECULE FOR PROGNOSING TUMOR GRADE OF HEAD NECK CANCER AND METHOD FOR THE SAME - The present invention discloses a labeled molecule for prognosing the tumor grade of head neck cancer and a method for the same, wherein a 78-kDA glucose regulated protein (GRP78) is adopted as a labeled molecule of head neck cancer. GRP78 is much more overexpressed in head neck cancer cells than in non-cancer cells. GRP78 also has relation with tumor size, tumor depth and tumor metastasis. Therefore, the present invention uses GRP78 overexpression as a reference for tumor grading of head neck cancer. | 2009-07-16 |
20090181483 | CRYSTALLIZATION APPARATUS, OPTICAL MEMBER FOR USE IN CRYSTALLIZATION APPARATUS, CRYSTALLIZATION METHOD, MANUFACTURING METHOD OF THIN FILM TRANSISTOR, AND MANUFACTURING METHOD OF MATRIX CIRCUIT SUBSTRATE OF DISPLAY - A crystallization method includes wavefront-dividing an incident light beam into a plurality of light beams, condensing the wavefront-divided light beams in a corresponding phase shift portion of a phase shift mask or in the vicinity of the phase shift portion to form a light beam having an light intensity distribution of an inverse peak pattern in which a light intensity is minimum in a point corresponding to the phase shift portion of the phase shift mask, and irradiating a polycrystalline semiconductor film or an amorphous semiconductor film with the light beam having the light intensity distribution to produce a crystallized semiconductor film. | 2009-07-16 |
20090181484 | SEMICONDUCTOR LIGHT EMITTING DEVICE AND METHOD OF MANUFACTURING THE SAME - Provided are a semiconductor light emitting device having a nano pattern and a method of manufacturing the semiconductor light emitting device. The semiconductor light emitting device includes: a semiconductor layer comprising a plurality of nano patterns, wherein the plurality of nano patterns are formed inside the semiconductor layer; and an active layer formed on the semiconductor layer. The optical output efficiency is increased and inner defects of the semiconductor light emitting device are reduced. | 2009-07-16 |
20090181485 | METHOD OF MANUFACTURING VERTICAL GALLIUM-NITRIDE BASED LIGHT EMITTING DIODE - A vertical GaN-based LED and a method of manufacturing the same are provided. The vertical GaN-based LED can prevent the damage of an n-type GaN layer contacting an n-type electrode, thereby stably securing the contact resistance of the n-electrode. The vertical GaN-based LED includes: a support layer; a p-electrode formed on the support layer; a p-type GaN layer formed on the p-electrode; an active layer formed on the p-type GaN layer; an n-type GaN layer for an n-type electrode contact, formed on the active layer; an etch stop layer formed on the n-type GaN layer to expose a portion of the n-type GaN layer; and an n-electrode formed on the n-type GaN layer exposed by the etch stop layer. | 2009-07-16 |
20090181486 | METHOD FOR PRODUCING A TRANSISTOR-TYPE HYDROGEN SENSOR - A method for producing a transistor-type hydrogen sensor is invented. This method combines conventional semiconductor fabrication process with an electroless plating technique. The fabrication process comprises steps as follows: (a) preparing a semiconductor substrate, (b) forming a semiconductor-based material with an exposed surface on the substrate, (c) washing and then drying the semiconductor-based material, (d) separating the exposed surface of the semiconductor-based material, (e) depositing a gold-germanium alloy on the semiconductor-based material to form two Ohmic contacts, and (f) forming a Schottky contact gate metal having an affinity for hydrogen. The electroless plating technique deposits the Schottky contact gate metal, having an affinity for hydrogen, at a relatively low temperature and it thus can produce a transistor-type hydrogen sensor with excellent sensing performances. | 2009-07-16 |
20090181487 | Method of making microminiature moving device - A microminiature moving device has disposed on a single-crystal silicon substrate movable elements such as a movable rod and a movable comb electrode that are displaceable in parallel to the substrate surface and stationary parts that are fixedly secured to the single-crystal silicon substrate with an insulating layer sandwiched between. Depressions are formed in the surface regions of the single-crystal silicon substrate where no stationary parts are present and the movable parts are positioned above the depressions. The depressions form gaps large enough to prevent foreign bodies from causing shorts and malfunctioning of the movable parts. | 2009-07-16 |
20090181488 | MEMS thermal actuator and method of manufacture - A separated MEMS thermal actuator is disclosed which is largely insensitive to creep in the cantilevered beams of the thermal actuator. In the separated MEMS thermal actuator, a inlaid cantilevered drive beam formed in the same plane, but separated from a passive beam by a small gap. Because the inlaid cantilevered drive beam and the passive beam are not directly coupled, any changes in the quiescent position of the inlaid cantilevered drive beam may not be transmitted to the passive beam, if the magnitude of the changes are less than the size of the gap. | 2009-07-16 |
20090181489 | MICROPHONE MANUFACTURING METHOD - A sacrifice layer | 2009-07-16 |
20090181490 | IMAGE SENSING DEVICES AND METHODS FOR FABRICATING THE SAME - Image sensing devices and methods for fabricating the same are provided. An exemplary image sensing device comprises a first substrate having a first side and a second side opposing each other. A plurality of image sensing elements is formed in the first substrate at the first side. A conductive via is formed through the first substrate, having a first surface exposed by the first substrate at the first side and a second surface exposed by the first substrate at the second side. A conductive pad overlies the conductive via at the first side and is electrically connecting the image sensing elements. A conductive layer overlies the conductive via at the second side and electrically connects with the conductive pad. A conductive bump is formed over a portion of the conductive layer. A second substrate is bonded with the first substrate at the first side. | 2009-07-16 |
20090181491 | High-Resolution Integrated X-Ray CMOS Image Sensor - An X-ray image sensor having scintillating material embedded into wave-guide structures fabricated in a CMOS image sensor (CIS). After the CIS has been fabricated, openings (deep pores) are formed in the back side of the CIS wafer. These openings terminate at a distance of about 1 to 5 microns below the upper silicon surface of the wafer. The depth of these openings can be controlled by stopping on a buried insulating layer, or by stopping on an epitaxial silicon layer having a distinctive doping concentration. The openings are aligned with corresponding photodiodes of the CIS. The openings may have a shape that narrows as approaching the photodiodes. A thin layer of a reflective material may be formed on the sidewalls of the openings, thereby improving the efficiency of the resulting waveguide structures. Scintillating material (e.g., CsI(Tl)) is introduced into the openings using a ForceFill™ technology or by mechanical pressing. | 2009-07-16 |
20090181492 | NANO-CLEAVE A THIN-FILM OF SILICON FOR SOLAR CELL FABRICATION - An approach for nano-cleaving a thin-film of silicon for solar cell fabrication is described. In one embodiment, there is a method of forming a substrate for use as a solar cell substrate. In this embodiment, a substrate of silicon is provided and implanted with an ion flux. A non-silicon substrate is attached to the thin-film of silicon to form a solar cell substrate. | 2009-07-16 |
20090181513 | VERTICAL ORGANIC TRANSISTOR - A vertical organic transistor and a method for fabricating the same are provided, wherein an emitter, a grid with openings and a collector are sequentially arranged above a substrate. Two organic semiconductor layers are interposed respectively between the emitter and the grid with openings and between the grid with openings and the collector. The channel length is simply decided by the thickness of the organic semiconductor layers. The collector current depends on the space-charge-limited current contributed by the potential difference between the emitter and the openings of the grid. And the grid voltage can thus effectively control the collector current. Further, the fabrication process of the vertical organic transistor of the present invention is simple and exempt from using the photolithographic process. | 2009-07-16 |
20090181514 | HEAT TREATMENT APPARATUS AND METHOD FOR MANUFACTURING SOI SUBSTRATE USING THE HEAT TREATMENT APPARATUS - A heat treatment apparatus is disclosed, which enables suppression of a warp of a base substrate to which a plurality of single crystal semiconductor substrates are bonded. An example of the apparatus comprises a treatment chamber, a supporting base provided in the treatment chamber, a plurality of supports which are provided over the supporting base and are arranged to support the base substrate, and a heating unit for heating the base substrate, where each position of the plurality of supports can be changed over the supporting base. The use of this apparatus contributes to the reduction in the region where the base substrate and the supports are in contact with each other, which allows uniform heating of the base substrate, leading to the formation of an SOI substrate with high quality. | 2009-07-16 |
20090181515 | Selective germanium deposition for pillar devices - A method of making a pillar device includes providing an insulating layer having an opening, and selectively depositing germanium or germanium rich silicon germanium semiconductor material into the opening to form the pillar device. | 2009-07-16 |
20090181516 | Method of Forming Isolation Layer of Semiconductor Device - A method of forming an isolation layer of a semiconductor device is disclosed. In the method according to one aspect, a semiconductor substrate having a trench formed therein is provided. A first insulating layer is formed over an entire surface of the semiconductor substrate including a surface of the trench. A passivation layer, preferably silicon, including oxygen is formed on a surface of the first insulating layer. A second insulating layer is formed on the passivation layer formed within the trench. | 2009-07-16 |
20090181517 | METHOD OF FORMING FLASH MEMORY DEVICE - The present invention relates to a method of forming a flash memory device, which is capable of forming floating gates. According to a method of forming a flash memory device in accordance with the present invention, isolation mask patterns are first formed over a semiconductor substrate. Trenches are formed by performing an etching process using the isolation mask patterns. Isolation layers are formed between the isolation mask patterns, including the insides of the respective trenches. The isolation mask patterns are removed. Tunnel dielectric layers and crystallized first conductive layers are sequentially formed over the exposed semiconductor substrate. A dielectric layer and a second conductive layer are formed over the isolation layers and the first conductive layers. | 2009-07-16 |
20090181518 | MANUFACTURING METHOD AND MANUFACTURING APPARATUS OF SEMICONDUCTOR SUBSTRATE - It is an object to provide a homogeneous semiconductor substrate in which defective bonding is reduced. Such a semiconductor substrate can be formed by the steps of: disposing a first substrate in a substrate bonding chamber which includes a substrate supporting base where a plurality of openings is provided, substrate supporting mechanisms provided in the plurality of openings, and raising and lowering mechanisms which raise and lower the substrate supporting mechanisms; disposing a second substrate over the first substrate so as not to be in contact with the first substrate; and bonding the first substrate to the second substrate by using the raising and lowering mechanisms to raise the substrate supporting mechanisms. | 2009-07-16 |
20090181519 | LAMINATION DEVICE MANUFACTURING METHOD - A lamination device manufacturing method for manufacturing a lamination device using a reinforced wafer formed with an annular reinforced portion, includes a wafer lamination step in which a rear surface of the reinforced wafer corresponding to the device area is faced to and joined to the front surface of an underlying wafer with corresponding streets aligned with each other, thus forming a lamination wafer; an electrode connection step in which a via-hole is formed at a position where an electrode is formed in each of the devices of the reinforced wafer constituting part of the lamination wafer, so as to reach a corresponding electrode formed in each of the devices of the underlying wafer, and the via-hole is filled with a conductive material to connect the electrodes; and a division step in which after the electrode connection step is executed, the lamination wafer is cut along the streets and divided into individual lamination devices. | 2009-07-16 |
20090181520 | Method and Structure for Dividing a Substrate into Individual Devices - A method for obtaining individual dies from a semiconductor structure is disclosed. The semiconductor structure includes a device layer, and the device layer in turn includes active regions separated by predefined spacings. Thick metal is selectively formed on backside of the device layer such that thick metal is formed on backside of active regions but not on backside of the predefined spacings. The semiconductor structure is then cut along the predefined spacings to separate the active regions with thick metal on their backside into individual dies. | 2009-07-16 |
20090181521 | Electronic component and semiconductor device, method of making the same and method of mounting the same, circuit board, and electronic instrument - A semiconductor device with its package size close to its chip size has a stress absorbing layer, allows a patterned flexible substrate to be omitted, and allows a plurality of components to be fabricated simultaneously. There is: a step of forming electrodes ( | 2009-07-16 |
20090181522 | Method for producing semiconductor optical device - To grasp a removable particle contamination and appropriately removing a particle contamination exposing from a surface of a semiconductor layer, this production method of the semiconductor optical device includes a surface treatment step in which particle contaminations removed from a surface of a cap layer | 2009-07-16 |
20090181523 | Method of manufacturing semiconductor device and apparatus for processing substrate - A process for producing a semiconductor device, in which in the formation of a boron doped silicon film from, for example, monosilane and boron trichloride by vacuum CVD technique, there can be produced a film excelling in inter-batch homogeneity with respect to the growth rate and concentration of a dopant element, such as boron. The process includes the step of performing the first purge through conducting at least once of while a substrate after treatment is housed in a reaction furnace, vacuuming of the reaction furnace and inert gas supply thereto and the steps of performing the second purge through conducting at least once of after carrying of the substrate after treatment out of the reaction furnace, prior to carrying of a substrate to be next treated into the reaction furnace and while at least no product substrate is housed in the reaction furnace, vacuuming of the reaction furnace and inert gas supply thereto. | 2009-07-16 |
20090181524 | Method of manufacturing semiconductor device and apparatus for processing substrate - A process for producing a semiconductor device, in which in the formation of a boron doped silicon film from, for example, monosilane and boron trichloride by vacuum CVD technique, there can be produced a film excelling in inter-batch homogeneity with respect to the growth rate and concentration of a dopant element, such as boron. The process includes the step of performing the first purge through conducting at least once of while a substrate after treatment is housed in a reaction furnace, vacuuming of the reaction furnace and inert gas supply thereto and the steps of performing the second purge through conducting at least once of after carrying of the substrate after treatment out of the reaction furnace, prior to carrying of a substrate to be next treated into the reaction furnace and while at least no product substrate is housed in the reaction furnace, vacuuming of the reaction furnace and inert gas supply thereto. | 2009-07-16 |
20090181525 | Wafer structure and epitaxial growth method for growing the same - A wafer structure and epitaxial growth method for growing the same. The method may include forming a mask layer having nano-sized areas on a wafer, forming a porous layer having nano-sized pores on a surface of the wafer by etching the mask layer and a surface of the wafer, and forming an epitaxial material layer on the porous layer using an epitaxial growth process. | 2009-07-16 |
20090181526 | Plasma Doping Method and Apparatus - An object of the invention is to provide a plasma doping method and a plasma doping apparatus in which uniformity of concentration of impurities introduced into a sample surface are excellent. | 2009-07-16 |
20090181527 | Graphite Member for Beam-Line Internal Member of Ion Implantation Apparatus - The problem of the present invention is to provide, in high current-low energy type ion implantation apparatuses, a graphite member for a beam line inner member of an ion implantation apparatus, which graphite member can markedly reduce particles incorporated in a wafer surface. This problem can be solved by the graphite member of the present invention, which is a graphite member for a beam line inner member of an ion implantation apparatus, which member having a bulk density of not less than 1.80 Mg/m | 2009-07-16 |
20090181528 | Method of Forming Gate Electrode - The present invention discloses to a method of forming a gate electrode, the method according to the present invention comprises the steps of forming a lower amorphous silicon layer using silane (SiH | 2009-07-16 |
20090181529 | Method of forming a contact hole and method of manufacturing a semiconductor device having the same - In a method of forming a contact hole and a method of manufacturing a semiconductor device having the same, a first insulation interlayer is formed on a substrate. A dummy pattern is formed on the first insulation interlayer. A second insulation interlayer is formed to cover the dummy pattern. A photoresist pattern is formed on the second insulation interlayer. The photoresist pattern has an exposed portion. The dummy pattern under the photoresist pattern is arranged to cross over the exposed portion of the photoresist pattern. The first and second insulation interlayers are etched using the photoresist pattern and the dummy pattern as an etching mask, to form a plurality of contact holes on both sides of the dummy pattern. Accordingly, the contact holes may be formed to have a smaller width. | 2009-07-16 |
20090181530 | High-K Dielectric Stack And Method Of Fabricating Same - A method for improving the reliability of a high-k dielectric layer or a high-k dielectric stack by forming an amorphous high-k dielectric layer over an insulating layer, doping the amorphous high-k dielectric layer with nitrogen atoms, and subsequently heating the resulting structure at a temperature greater than or equal to the crystallization temperature of the high-k dielectric material, thereby transforming the high-k dielectric material from an amorphous state to a crystalline state, and causing nitrogen atoms to diffuse into the insulating layer. | 2009-07-16 |
20090181531 | METHODS OF MANUFACTURING NON-VOLATILE MEMORY DEVICES HAVING INSULATING LAYERS TREATED USING NEUTRAL BEAM IRRADIATION - Methods of manufacturing non-volatile memory devices that can reduce or prevent loss of charges stored in a charge storage layer and/or that can improve charge storage capacity by neutral beam irradiation of an insulating layer are disclosed. The methods include forming a tunneling insulating layer on a substrate, forming a charge storage layer on the tunneling insulating layer, forming a blocking insulating layer on the charge storage layer, irradiating the blocking insulating layer and/or the tunneling insulating layer with a neutral beam, and forming a gate conductive layer on the blocking insulating layer. | 2009-07-16 |
20090181532 | INTEGRATION SCHEME FOR EXTENSION OF VIA OPENING DEPTH - An interconnect structure having an incomplete via opening is processed to deepen a via opening and to expose a metal line. In case the interconnect structure comprises a metal pad or a blanket metal layer, the metal pad or the metal layer is removed selective to an underlying dielectric layer to expose the incomplete via opening. Another dielectric layer is formed within the incomplete via opening to compensated for differences in the total dielectric thickness above the metal line relative to an optimal dielectric stack. A photoresist is applied thereupon and patterned. An anisotropic etch process for formation of a normal via opening may be employed with no or minimal modification to form a proper via opening and to expose the metal line. A metal pad is formed upon the metal line so that electrical contact is provided between the metal pad and the metal line. | 2009-07-16 |
20090181543 | METHOD OF FORMING A PATTERN OF A SEMICONDUCTOR DEVICE - In a method of forming patterns of a semiconductor device, a to-be-etched layer is formed on a semiconductor substrate. First etch mask patterns are formed over the to-be-etched layer. An auxiliary layer is formed on the first etch mask patterns and the to-be-etched layer. The auxiliary layer is thicker on upper sidewalls of the first etch mask patterns than on lower sidewalls thereof. Second etch mask patterns are formed in concave portions of the auxiliary layer. The auxiliary layer between the first and second etch mask patterns is removed. The to-be-etched layer is patterned using the first and second etch mask patterns as an etch mask. | 2009-07-16 |
20090181544 | METHOD FOR PREVENTING BACKSIDE DEFECTS IN DIELECTRIC LAYERS FORMED ON SEMICONDUCTOR SUBSTRATES - A method of forming a TEOS oxide layer over an nitrogen doped silicon carbide or nitrogen doped hydrogenated silicon carbide layer formed on a substrate. The method includes forming the nitrogen doped silicon carbide or nitrogen doped hydrogenated silicon carbide layer on a top surface and a top side beveled edge proximate to the top surface of a substrate; removing or preventing formation of a carbon-rich layer on a bottom side bevel edge region proximate to a bottom surface of the substrate or converting the carbon-rich layer to nitrogen doped silicon carbide or nitrogen doped hydrogenated silicon carbide; and forming the TEOS oxide layer on the top surface, the top side beveled edge and the bottom side bevel edge region of the substrate. | 2009-07-16 |
20090181545 | DRY-ETCHING METHOD AND APPARATUS - A resist damage free dry-etching process is proposed. A time duration defined until bias electric power is applied is controlled according to a plasma ignition detection signal. Wafer back-side gas pressure for a certain constant time after starting of an etching process operation is set to be lower than that as to a main etching condition. Within the time duration defined after starting of the etching process operation up to a certain constant time, C | 2009-07-16 |
20090181546 | Single-Wafer Etching Method for Wafer and Etching Apparatus Thereof - A single-wafer etching apparatus according to the present invention supplies an etchant to an upper surface of a wafer while rotating the wafer, thereby etching the upper surface of the wafer. Further, wafer elevating means moves up and down the wafer, and a lower surface blow mechanism which blows off the etchant flowing down on an edge surface of the wafer toward a radially outer side of the wafer by injection of a gas is fixed and provided without rotating together with the wafer. Furthermore, gap adjusting means controls the wafer elevating means based on detection outputs from gap detecting means for detecting a gap between the wafer and the lower surface blow mechanism, thereby adjusting the gap. The apparatus according to the present invention uniformly etches the edge portion without collapsing a chamfered shape of the edge portion of the wafer, and prevents a glitter from being produced on the edge surface of the wafer. | 2009-07-16 |