28th week of 2010 patent applcation highlights part 30 |
Patent application number | Title | Published |
20100178314 | FREEZE-DRIED FIBRIN MATRICES AND METHODS FOR PREPARATION THEREOF - Methods for producing porous freeze-dried fibrin matrices substantially devoid of external anti-fibrinolytic agents. Resilient matrices, also known as sponges, that are particularly beneficial for supporting three dimensional cell growth are obtained from plasma proteins substantially devoid of plasminogen or from partially purified plasma proteins, thus obviating the need for exogenous anti-fibrinolytic agents. Furthermore, incorporation of glycosaminoglycans and bioactive agents during the formation of the matrix results in a sponge having advantageous biological, mechanical and physical properties. The compositions made by the processes of the present invention are useful clinically, per se or as cell-bearing implants. | 2010-07-15 |
20100178315 | POLYMERIC SYSTEMS FOR CONTROLLED DRUG THERAPY - Polymeric compositions containing a high percentage of bound alkyl ether segments provide matrices and membranes for the controlled release of drugs and medicinal agents. The polymeric compositions are prepared by the polymerization of ethylenically unsaturated alkyl ether containing monomers. Copolymers of ethylenically unsaturated alkyl ether containing monomers with co-monomers are also disclosed. The drug loaded polymeric compositions of this invention find particular utility in the construction of controlled release devices. | 2010-07-15 |
20100178316 | EXTENDED RELEASE OF BIOACTIVE MOLECULES FROM SILICONE HYDROGELS - A dosage form for the administration of a biologically active agent is a silicone hydrogel appliance where the agent is absorbed in a copolymer of at least one siloxane containing monomer and at least one hydrophilic monomer where the appliance is placed in contact with a tissue surface of the patient, such as a contact lens placed in the eye. The appliance can be formed where a copolymer of the siloxane containing and hydrophobic monomers is soaked in a solution of the biologically active agent. The agent can be a non-ionic drug which is absorbed into the appliance from a non-aqueous solution, such as an ethanol solution. | 2010-07-15 |
20100178317 | Lens Care Solutions with Hyaluronic Acid - A method of retaining hyaluronic acid on a surface of a contact lens. The method comprises providing a contact lens care solution comprising;
| 2010-07-15 |
20100178318 | Composite Structure Including A Low Vinyl Acetate Layer - A composite structure suitable for making transdermal delivery devices includes in sequence: (a) a liner film layer; (b) a containment layer having from zero to 15 wt. % content of vinyl acetate repeating units, the layer including either a thermal bonding copolyester resin or a combination of an ethylene-vinyl acetate component and a nonpolar polymer; and (c) a polyester film layer less than 20 μm in thickness. A drug layer lies either between the liner film layer and the containment layer or within a concave depression in the containment layer. A composition including an ethylene-vinyl acetate component and an ABA block copolymer, wherein the A segments of the block copolymer are styrenic segments, is also provided. The composition includes between 1 and 15 wt. % of vinyl acetate repeating units, based on the total weight of composition exclusive of any solvents. | 2010-07-15 |
20100178319 | Topical Dermal Delivery Device For Nitric Oxide Delivery - A topical dermal delivery device, such as a patch, for topical delivery of nitric oxide (NO) to treatment sites of mammals is disclosed. In an embodiment the patch has three layers; a backing with an activation window, a absorbent core as a reservoir and an NO permeable membrane with an adhesive layer towards the skin. The NO donor is applied into the device as a solution prior to application through the activation window. The window is closed after activation and the lid and backing is non-permeable for NO in order to increase the partial pressure of NO and thus the concentration of dissolved NO. The patch is fixated on the area to be treated with an adhesive layer that also assures sufficient contact throughout the treatment. The generated NO moves within the patch and can escape through the NO permeable membrane towards the area to be treated. Depending on therapy needed, the patch release curve differs and is chosen accordingly. | 2010-07-15 |
20100178320 | NEW MEDICAL PRODUCTS - The present invention provides a wound care product comprising a wound care material and a polypeptide having wound care properties. In one embodiment, the wound care material comprises or consists of alginates, amorphous hydrogels, sheet hydrogels, hydrofibres, foams and mixtures thereof. In a further embodiment, the polypeptide having wound care properties is a cathelicidin, such as LL-37. The invention further provides methods of treatment of wounds using the products of the invention. | 2010-07-15 |
20100178321 | PRESSURE-SENSITIVE ADHESIVE COMPOSITION APPLICABLE TO NAIL AND ADHESIVE AGENT FOR NAIL - The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition. | 2010-07-15 |
20100178322 | Adhesive preparation and patch preparation - An adhesive preparation comprising an adhesive preparation main body comprising a support and an adhesive layer laminated on at least one surface of the support, and a release liner formed on a surface on the side opposite from the support side of the adhesive layer of the adhesive preparation main body, wherein the adhesive preparation main body has a flat plane area of 1.5-15 cm | 2010-07-15 |
20100178323 | Dermal Delivery Device - A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%. | 2010-07-15 |
20100178324 | COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES AFFECTED BY APOPTOSIS - The present invention includes methods of making and methods of using peptidomimetics compositions that mimic α-helical BH3 sequences in cells. The peptidomimetics can be used to mimic α-helical BH3 sequences and kill cancer cells. | 2010-07-15 |
20100178325 | AMPHIPHILIC NUCLEOTIDE COCHLEATE COMPOSITIONS AND METHODS OF USING THE SAME - The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein. | 2010-07-15 |
20100178326 | AMINOPHOSPHONATE CARRIERS FOR LIPOSOME-BASED DRUG RELEASE SYSTEMS - A novel class of carriers for liposome-based drug delivery and release systems is provided. Such carriers exhibit excellent compatibility with hydrophilic drug compounds as well as effective release upon transport through phospholipid bilayers of cell membranes. Furthermore, such carriers are non-cytotoxic, particularly in terms of contact with cell membranes themselves. As such, these carriers accord an excellent manner of transporting pharmaceutical and other like compounds and materials to a user's individual cells for delayed release thereof at the site necessary to effectuate proper treatment. Drug delivery materials including such carriers are encompassed within this invention, as well as the overall method of drug delivery and delayed release provided thereby. | 2010-07-15 |
20100178327 | ACTIVE INGREDIENT OF A MEDICINAL AGENT, A MEDICINAL AGENT, A PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING DEMENTIA SYNDROME PATIENTS - The invention relates to an area of the chemical-pharmaceutical industry and medicine, particularly to an agent for treatment of dementias, including Alzheimer's disease (AD), as well as to a method of treatment and pharmaceutical composition, which is effective for both treatment of dementias, including AD or dementias of Alzheimer type, and during manifestations of the first symptoms of memory disorder. | 2010-07-15 |
20100178328 | COMBINATION THERAPY FOR OVARIAN CANCER - The present invention provides a method to treat ovarian cancer by the administration of effective amounts of picoplatin and pegylated liposomal doxorubicin. | 2010-07-15 |
20100178329 | LIPOSOME COMPOSITION - The invention relates to a liposomal composition, containing a citrus type (Aurantioideae) essential oil of pharmaceutical grade 0.5-5.0 part by weight; lavender oil of pharmaceutical grade 0.5-5.0 part by weight; vitamin E 0.1-1.5 part by weight; vitamin A 0.1-1.5 part by weight; castor oil ethoxylated 1.0-6.0 part by weight; a phospholipid 0.1-1.0 part by weight; distilled water 15-30 part by weight; ethanol 96% 65-75 part by weight. The composition can be used for treatment of wounded, burned, frozen, infected skin surfaces. | 2010-07-15 |
20100178330 | ASYMMETRIC LIPOSOMES AND USES IN MEDICAL FIELD THEREOF - The invention concerns new asymmetric liposomes and uses thereof in medical field to transport lipids involved in antimicrobial or antiviral response, particularly at level of pulmonary target cells. | 2010-07-15 |
20100178331 | PREPARATION FOR TRANSNASAL APPLICATION - Disclosed is a preparation for transnasal application, which has improved fluidability. Specifically disclosed is a preparation for transnasal application, which comprises at least a complex comprising: a fluidability-improving component comprising a first crystalline cellulose (A) having specified powder properties, tricalcium phosphate (B) having specified powder properties, and a second crystalline cellulose (C) having specified powder properties or a starch (D) having specified powder properties; and a physiologically active substance. | 2010-07-15 |
20100178332 | CELLULOSE-BASED FINE CORE PARTICLE AND PROCESS FOR PRODUCING THE SAME - It is an object of the present invention to provide a fine core particle, which comprises a coating layer having a uniform thickness, and which can be used to produce, at a high yield, a small granule causing no sandy feeling in the oral cavity when the fine core particle is applied to a fine granule or an orally-disintegrating tablet. According to the present invention, there is provided a core particle, which comprises 50% by mass or more of microcrystalline cellulose, and which has a mean particle diameter of less than 100 μm, a relative flow index of 7.0 to 30.0, a specific surface area of less than 0.15 m | 2010-07-15 |
20100178333 | SUSTAINED RELEASE DOSAGE FORM OF PHENOTHIAZINE DERIVATIVES CONTAINING CHANNELIZER - Once a day sustained release solid oral dosage form of phenothiazine derivative preferably the dibenzothiazepine derivative and their pharmaceutically acceptable salts comprising of a channelizer, rate controlling polymer and suitable pharmaceutically acceptable excipients. The formulation of the present invention is in the form of tablet or capsule which provides a sustained drug action upto 24 hours upon single dose administration. | 2010-07-15 |
20100178334 | Oral Pharmaceutical Dosage Form Comprising as Active Ingredients a Proton Pump Inhibitor together with Acetyl Salicyclic Acid - The present invention relates to an oral pharmaceutical preparation for use in the prevention and/or reduction of gastrointestinal complications associated with the use of acetyl salicylic acid. The present preparation comprises a fixed oral dosage form comprising a proton pump inhibitor in combination with acetyl salicylic acid. Furthermore, the present invention refers to a method for the manufacture thereof and the use thereof in medicine. The present invention also relates to a specific combination comprising esomeprazole, or an alkaline salt thereof or a hydrated form of any one of them, and acetyl salicylic acid for use as a medicament for the prevention of thromboembolic vascular events, such as myocardial infarction or stroke, and for the prevention and/or reduction of gastrointestinal complications associated with the use of acetyl salicylic acid. | 2010-07-15 |
20100178335 | Formulations of acetylsalicylic acid or its derivatives in soft capsules, exhibiting high stability - The present invention relates to new formulations comprising acetylsalicylic acid or its derivatives an oil phase and a cyclodextria in soft capsules, characterized by a high stability. | 2010-07-15 |
20100178336 | STABILIZED AMORPHOUS FORMS OF IMATINIB MESYLATE - The invention relates to the stabilized amorphous form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N--[4-methyl-3-( 4-(pyridin-3-yl)-pyrimidin-2-ylamino)-phenyl]-benzamide, pharmaceutical compositions such as capsules or tablets containing this form, the use of such form in diagnostic methods or, preferably, for the therapeutic treatment of warm-blooded animals, especially humans, and the use of formulation principles stabilizing the amorphous form of Imatinib mesylate as an intermediate for the preparation of pharmaceutical compositions. | 2010-07-15 |
20100178337 | Composition comprising an active agent with low aqueous solubility - The present invention relates to a composition comprising at least one active ingredient with low aqueous solubility, said active ingredient being present therein in a form noncovalently associated with nanoparticles formed by at least one POM polymer of formula (I), and in which said active ingredient is present in a proportion of at least 5 μmol/g of POM. | 2010-07-15 |
20100178338 | STABILIZED PHARMACEUTICAL COMPOSITIONS COMPRISING ATORVASTATIN - This invention relates to stabilized pharmaceutical compositions comprising atorvastatin or pharmaceutically acceptable salts thereof, and processes for the preparation of the same. | 2010-07-15 |
20100178339 | TABLETED COMPOSITIONS CONTAINING ATAZANAVIR - Disclosed are compressed tablets containing atazanavir sulfate, optionally with another active agents, e.g., anti-HIV agents, granules that contain atazanavir sulfate and an intragranular lubricant that can be used to make the tablets, compositions comprising a plurality of the granules, processes for making the granules and tablets, and methods of treating HIV. | 2010-07-15 |
20100178340 | TABLETED COMPOSITIONS CONTAINING ATAZANAVIR - Disclosed are compressed tablets containing atazanavir sulfate, optionally with another active agents, e.g., anti-HIV agents, granules that contain atazanavir sulfate and an intragranular lubricant that can be used to make the tablets, compositions comprising a plurality of the granules, processes for making the granules and tablets, and methods of treating HIV. | 2010-07-15 |
20100178341 | BILAYERED TABLET COMPRISING NIACIN AND HMG-CoA REDUCTASE INHIBITOR - The present invention relates to a bilayered tablet comprising: a slow release layer comprising niacin and release retarding agent; and an immediate release layer comprising HMG-CoA reductase inhibitor. | 2010-07-15 |
20100178342 | Solid Pharmaceutical Preparation - The invention relates to a solid pharmaceutical preparation containing one or more solid carriers and/or excipients and an active substance selected from among the Monoamine Neurotransmitter Re-uptake Inhibitors which have a 2,3-disubstituted tropane structure, the preparation thereof and use thereof for preparing a pharmaceutical composition for the treatment or prevention of central-nervous diseases or disorders. | 2010-07-15 |
20100178343 | STORAGE-STABLE LAMINATE SEGMENTS - The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers. | 2010-07-15 |
20100178344 | Extended-Release Composition Comprising a Somatostatin Derivative in Microparticles - The present invention relates to improved microparticles comprising a somatostatin analogue, a process of making said microparticles and to pharmaceutical compositions comprising the same. | 2010-07-15 |
20100178345 | Hydrogel Microparticle Composition, Application Thereof and Method for Preparing the Same - Disclosed herein is a method for preparing a hydrogel microparticle composition. A dispersion including 1 part by weight of N-isopropyl acrylamide, about 0.1-0.5 part by weight of chitosan, about 0-0.05 part by weight of N,N′-methylene bisacrylamide, about 0.1-0.5 part by weight of glacial acetic acid, and about 20-40 parts by weight of water is prepared. About 0.01-0.3 part by weight of an anionic initiator is added into the dispersion and the dispersion is allowed to undergo a polymerization reaction at a temperature of about 10-100° C. for about 1 to 5 hours, thereby producing a plurality of hydrogel microparticles dispersed in the water to form the hydrogel microparticle composition. | 2010-07-15 |
20100178346 | DISC AUGMENTATION WITH HYALURONIC ACID - The present invention relates to materials comprising hyaluronic acid for replacement or augmentation of the nucleus pulposus The materials have a Poisson's ratio of 0.40 to 0.80 based on that of the human nucleus pulposus. | 2010-07-15 |
20100178347 | Method of treating traumatic brain injury - This invention provides for methods of treating a subject suffering from central nervous system injury, including traumatic brain injury, comprising administering to the subject an amount of a perfluorocarbon. This invention also provides for use of a perfluorocarbon in the manufacture of a medicament for treating a subject suffering from central nervous system injury including traumatic brain injury. This invention further provides for a pharmaceutical composition comprising a perfluorocarbon for use in treating a subject suffering from central nervous system injury, including traumatic brain injury. | 2010-07-15 |
20100178348 | Myostatin Inhibition for Enhancing Muscle and/or Improving Muscle Function - The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving muscle function (including decreasing atrophy and/or increasing endurance, force and/or strength). The methods involve delivering genes to cells using gene delivery in order to inhibit myostatin. Examples of genes to be delivered are genes encoding’ proteins such as Follistatin, Follistatin-related gene-1 (FLRG-I), growth differentiation factor associated protein-1 (GASP-I) and myostatin precursor propeptide. The genes are delivered using a recombinant Adeno-associated virus (rAAV) lacking rep and cap DNA capable of infecting the cells. Following introduction, the genes are expressed in the cell body of the infected cell and the encoded proteins are secreted systemically. In other methods-of the invention expression of proteins such as activin lib and myostatin is inhibited by oligonucleotide techniques to effect muscle enhancement. All the methods have applications in the treatment of musculoskeletal and neurodegenerative disorders among others, as well as enhancing muscle in livestock. | 2010-07-15 |
20100178349 | PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF RAPIDLY DISINTEGRATING TABLETS - Pharmaceutical formulation in the form of agglomerates comprising
| 2010-07-15 |
20100178350 | AMINO-ACID-CONTAINING MEDICINAL GRANULAR PREPARATION HIGHLY EASY TO TAKE - The present invention aims to provide an amino acid-containing granule preparation improved in the ease of taking medication than conventional products, which disintegrates rapidly. The amino acid-containing granule preparation of the present invention containing granules having a maximum particle size of substantially not more than 1000 μm and a bulk density of not less than 0.57 g/mL markedly improves ease of taking medication without impairing disintegration property, as compared to conventional amino acid-containing granule preparations. | 2010-07-15 |
20100178351 | HYDROPHILIZED SUBSTRATE, DISPERSION, AND MAKING METHOD - A powder is hydrophilized by treating surfaces of particles with a hydrolyzable silyl group-containing acid anhydride compound, dispersing the surface treated particles in water, adding a base, and heating the dispersion for thereby hydrolyzing the acid anhydride moiety to open its ring and neutralizing the resultant carboxylic acid with the base. The hydrophilized powder is fully dispersible in aqueous media. | 2010-07-15 |
20100178352 | UNIFORMLY ABRASIVE CONFECTIONERY PRODUCT AND PROCESS THEREFOR - The present invention relates to the field of confectionery products. More particularly, the invention relates to an abrasive confectionery product and a process for producing the same. The product comprises abrasive inclusions which are uniformly dispersed throughout a base material. | 2010-07-15 |
20100178353 | QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON - The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability. | 2010-07-15 |
20100178354 | Remedy - It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated. | 2010-07-15 |
20100178355 | METHOD FOR IN SITU SOLIDIFICATION OF BLOOD-POLYMER COMPOSITIONS FOR REGENERATIVE MEDICINE AND CARTILAGE REPAIR APPLICATIONS - The present invention relates to a method for repairing or regenerating tissues in a patient such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, cardiac tissues and ulcers. The method comprises the step of administering simultaneously or sequentially a pro-coagulant factor and an effective amount of a polymer composition comprising a biocompatible polymer and blood or a component thereof. When the polymer composition is in contact with the pro-coagulant factor it is converted into a non-liquid state such that the polymer composition will adhere to the site in need of repair to effect repair of the tissue and/or regeneration thereof. | 2010-07-15 |
20100178356 | Composition and method for enhanced sanitation and oxidation of aqueous systems - This invention relates to a method for enhanced sanitation and oxidation of aqueous solutions at aquatic facilities. The method provides a means for the in-situ generation of chlorine dioxide from dilute solutions of chlorite anions at near neutral pH, and enhanced inactivation rates of microbiological organisms including cryptosporidium. | 2010-07-15 |
20100178357 | COMBINATIONS OF 4 BROMO-2-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRROLE-3-CARBONITRILE AND OXIDIZING AGENTS - The present invention relates to the use of combinations of 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile and an oxidizing agent, for eradicating, eliminating or reducing aquatic organisms in ballast water or bilge water whereby 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile and the oxidizing agent are in respective proportions to provide a synergistic effect against fouling organisms. Suitable oxidizing agents are e.g. bromine, chlorine, ozone, sodium hypochlorite, chlorine dioxide, hydrogen peroxide, potassium permanganate, potassium ferrate, peroxydisulfates such as ammonium peroxydisulfate, sodium peroxydisulfate, and potassium peroxydisulfate; peroxymonocarbonates such as calcium peroxycarbonate and sodium peroxycarbonate; peroxydicarbonates such as sodium peroxydicarbonate and potassium peroxydicarbonate; superoxides such as potassium superoxide and sodium superoxide; peroxides such as potassium peroxide, and sodium peroxide; and Fremy's salts such as potassium nitrosodisulfonate, sodium nitrosodisulfonate, and disodium nitrosodisulfonate. | 2010-07-15 |
20100178358 | POLYSACCHARIDE-BASED IMPREGNATED SOLID MATERIAL WITH IMPROVED STABILITY, PROCESSES FOR THE PREPARATION THEREOF AND IMPREGNATING SOLUTIONS USED - A polysaccharide-based solid material including, in its mass, at least one active agent having bactericidal, fungal, insecticidal and/or flame-retardant properties, and at least one complexing agent and/or at least one polymeric matrix having a complexing agent. The active agent includes at least one compound selected from the group including boron, silica, aluminum, phosphorus, iodine, derivatives thereof, aluminosilicate derivatives, and mixtures thereof. The solid material is characterized by an improved stability and by reduced environmental impact, and makes it possible to prepare materials based on wood particles and woods having a particular resistance against environmental attacks such as moisture. | 2010-07-15 |
20100178359 | FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING INORGANIC COPPER COMPOUND AS ACTIVE INGREDIENT - Disclosed is a fungicide for agricultural and horticultural use which is characterized by containing an inorganic copper compound and a polymer thickener having a sulfonyl group. This fungicide for agricultural and horticultural use exhibits higher plant disease-control effects than conventional inorganic copper-based fungicides. | 2010-07-15 |
20100178360 | NUTRITIVE COMPOSITION - An energetic or nutritive composition includes at least one compound having laxative properties, mineral salts (or electrolytes) such as sodium, potassium, chlorine, calcium, magnesium, phosphor. The composition may also include carbohydrates that may be assimilated by the human digestive system such as glucose, galactose, fructose, maltose, saccharose, polysaccharides. | 2010-07-15 |
20100178361 | METHOD OF STABILIZING IRON COMPOSITIONS WITH MILK PROTEIN - There are provided an iron composition including a milk protein and an iron preparation, which is stable in the presence of a substance having a property of releasing iron from the composition or reducing the released iron, and foods or drinks, animal feeds, and medicines blended with the iron composition. A milk protein such as skim milk is blended into an iron preparation, thereby producing the iron composition which is stable in the presence of a substance having a property of releasing iron from the composition or reducing the released iron (e.g., vitamin C or citric acid). | 2010-07-15 |
20100178362 | CHROMIUM COMPLEXES FOR IMPROVEMENT OF MEMORY AND COGNITIVE FUNCTION - A method of treating impaired memory and/or cognitive function by administering one or more chromium complexes, for example chromium picolinate, to an individual in need of improved memory and/or cognitive function. This method is used to improve memory and/or cognitive function associated with various disorders, including Alzheimer's disease, dementia, and mild cognitive impairment (MCI). Chromium complexes for treating memory or cognitive impairment are also disclosed. | 2010-07-15 |
20100178363 | AGENT FOR PREVENTING BLEEDING FROM CEREBRAL CORTICAL VEIN - The present invention provides: a superficial cerebral vascular bleeding inhibitor comprising an aqueous solution containing 120 to 160 mEq/L of sodium ion, 1 to 5 mEq/L of calcium ion, and 75 to 165 mEq/L of chloride ion; the superficial cerebral vascular bleeding inhibitor further comprising 1 to 5 mEq/L of potassium ion; and a packaged container containing the superficial cerebral vascular bleeding inhibitor (with or without potassium ion). The superficial cerebral vascular bleeding inhibitor of the present invention can effectively prevent or inhibit bleeding from superficial cerebral blood vessels in the field of neurosurgery such as intracranial surgery and the like, thereby capable of securing a clear operating field during intracranial surgery and inhibiting the occurrence of post-surgery damage. | 2010-07-15 |
20100178364 | Dietary supplements against latent foreign DNA - The invention presents methods for decreasing the concentration of a foreign polynucleotide in a human or animal subject, especially, when such polynucleotide is latent in the subject. | 2010-07-15 |
20100178365 | EPICATECHIN DEFICIENT GREEN TEA - The present application describes a method of eliminating gallated catechins, especially epigallocatechin gallate (EGCG), epicatechin gallate (ECG), as well as parathion, from green tea extraction by using at least one out of ethyl acetate, Cetyl Trimethyl Ammonium Bromide (CTAB), cation exchange resin, anion exchange resin, C18 bead, PEG bead and mPEG. And also, this method can be applied in the method of adding at least one of pre-mentioned components, when green tea is directly ingested in the form of an extract solution, leaf or powder. This is to be useful for people with metabolic disorders such as diabetes and obesity because of the resolved toxicity. This method is to maximize the beneficial luminal effect and to minimize the harmful circulatory effect of gallated catechins. | 2010-07-15 |
20100178366 | FRUIT FIBER GEL - Gelification is an important topic in many types of consumer products today, such as foods, cosmetical or medical products but also in paints or adhesives. The present invention relates to the field of gels and gelling material and their applications. In particular, the present invention relates to a gel comprising a liquid medium and a gel matrix comprising sheared cell wall material from ripe and soft botanical fruits, its preparation, its possible uses, a product comprising such a gel and the corresponding gel building material and its application. | 2010-07-15 |
20100178367 | HERBAL FORMULATION FOR WOUND HEALING - The present invention pertains to a herbal formulation with highly potent wound healing properties, in humans and animals. The composition consists of aqueous extracts of | 2010-07-15 |
20100178368 | PLANT EXTRACT AND ITS THERAPEUTIC USE - A composition comprising an aqueous extract of camomile flowers is useful for the treatment of a proliferative and/or inflammatory condition. | 2010-07-15 |
20100178369 | ANTIOXIDANT-STABILIZED CONCENTRATED FISH OIL - The present disclosure relates to antioxidant-stabilized composition containing at least one omega 3 polyunsaturated fatty acid (PUFA). The omega 3 PUFA may include eicosapentanoic acid, docosahexaneoic acid and combinations thereof. The compositions additionally contain an antioxidant package made from a mixture of: at least one form of vitamin E; ascorbyl palmitate; rosemary extract; and grape seed oil. The present disclosure further relates to a method of increasing the oxidative stability of concentrated fish oil. | 2010-07-15 |
20100178370 | COMPOSITION FOR PREVENTION AND/OR TREATMENT OF TUMORS CONTAINING ACACIA BARK DERIVATIVE - It is intended to provide a composition which is useful in preventing or treating a tumor. The composition is a composition for the prevention and/or treatment of a tumor, containing an | 2010-07-15 |
20100178371 | COMPOSITION FOR SUPRESSING APPETITE, IMPROVING TONE AND MOOD, WITH A NATURAL ANTIDEPRESSANT ACTIVITY AND WITH AN ANTIASTHENIC EFFECT - Compositions comprising L-tryptophan and/or 5-hydroxytryptophan are used for preparing a product suitable for sublingual or nasal administration which is helpful in suppressing appetite in such a manner as to promote weight loss in an individual; such compositions furthermore exhibit an antidepressant activity and an antiasthenic effect which makes them helpful in improving tone and mood and the level of attention in an individual. The compositions preferably comprise phenylethylamine in a synergistic combination which substance is contained in an algal plant extract, preferably of Klamath algae. | 2010-07-15 |
20100178372 | DEVICE FOR MELTBLOWING - A device for meltblowing of synthetic fibers utilizes an elongated spinneret packet that is held at the bottom side of the spinneret carrier. In order to supply process air the two elongated air tubes extend at the opposite longitudinal sides of the spinneret carrier, which are connected to an air distribution device having an air channel system in the spinneret carrier. In order to avoid thermal stress in the expansion joints between the air distribution device and the spinneret carrier as much as possible, the air distribution devices are embodied by means of multiple distribution segments having an expansion joint between adjacent distribution segments. | 2010-07-15 |
20100178373 | APPARATUS AND METHOD FOR PROTECTING LINED CONCRETE PIPE DURING THE MANUFACTURING PROCESS - At the filling station of a dry cast pipe making machine for making pipe lined with a plastic liner, the liner is first placed over the core and then a plurality of spaced-apart, removable L-shaped plates are secured around the top edge of the core. One leg of each plate extends inside the core with the other leg extending downwardly over the top edge of the liner. The plates are removably held in place on the core by the use of a clamping device, such as a vise-grip, for example. Once the form is filled with concrete and ready for the pressure heading step, the downwardly extending legs of the plates serve as ‘shoehorns’ to guide the pressure header over the top of the liner and prevent damage to it. In addition, the plates will assist in centering the core within the jacket. | 2010-07-15 |
20100178374 | MOLD FOR PRODUCING SILICA CRUCIBLE - In a mold for use in the production of a silica crucible, a cylindrical rim member is engagedly supported through hooks to an inner side of an upper opening portion of the mold corresponding to an upper part of a silica crucible and an outer diameter of the rim member is smaller than an inner diameter of the mold but larger than an inner diameter of the silica crucible. | 2010-07-15 |
20100178375 | MOLD FOR PRODUCING SILICA CRUCIBLE - There is provided a mold for use in the production of a silica crucible by heat-fusing silica or quartz powder attached onto an inner wall of a rotating mold, wherein an inner side of an upper opening portion of the mold corresponding to an upper part of the silica crucible is ground to obtain a step portion and a ring-shaped heat insulating barrier member having an inner diameter smaller than that of the mold is disposed on the step portion through a hollow disk-shaped support member having an inner diameter equal to or somewhat larger than that of the heat insulating barrier member. | 2010-07-15 |
20100178376 | Injection mold device - An injection mold device includes: a stationary mold plate including a stationary mold body, a protrusion, and a sprue having a sprue open end; a movable mold plate formed with a first forming part; and a stripper plate including a stripper mold body, a recess, a second forming part, and a plurality of runners. When the stationary mold plate, the movable mold plate, and the stripper plate are assembled, the protrusion is received within the recess such that the sprue open end is in fluid communication with the runners, and the first forming part and the second forming part form a mold cavity. | 2010-07-15 |
20100178377 | INJECTION MECHANISM, INJECTION MOLDING MACHINE AND OPTICAL ELEMENT - In repeating strokes for injecting a resin material, a piston ( | 2010-07-15 |
20100178378 | MOLD FOR USE IN INJECTION MOLDING PROCESS - A mold for use in an injection molding process includes a molding plate, a molding block and a plurality of mold cores. The molding plate defines a receiving cavity, a plurality of through holes and a plurality of elongate gates. The through holes surround the receiving cavity, and each of the elongate gates communicates with the receiving cavity and the corresponding through hole. The molding block is detectably received in the receiving cavity. The molding block defines a cold slug well and a plurality of runners. Each runner communicates with the cold slug well and the corresponding elongate gate. Each mold core is received in the corresponding through hole. | 2010-07-15 |
20100178379 | PREMIX FOR HOG FEED AND A METHOD OF FEEDING A HOG TO PRODUCE DHA AND EPA ENRICHED PORK - A premix for hog feed and a method of feeding a hog that produces DHA and EPA enriched pork while avoiding or reducing negative effects to the taste, colour, texture, aroma, pH and shelf life which are significant enough to make the pork unacceptable to consumers. One embodiment of the method of feeding a hog involves feeding a hog over several days with a hog feed supplemented with the premix. The premix includes marine-sourced docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and plant-sourced alpha-linolenic acid (ALA). The hogs are fed until their total DHA, EPA and ALA intakes are in a certain range per kilogram of the hog's weight. The hogs are then slaughtered and processed into pork products. This results in pork with an enrichment of omega-3 EFAs in the range of about 2.5% to about 4.5% of fat. | 2010-07-15 |
20100178380 | Synthesis and applications of 2-OXO-4-methylthiobutyric acid, its salts and its derivatives - The invention relates to a process for preparing 2-oxo-4-methylthiobutyric acid (I), its salts and its derivatives | 2010-07-15 |
20100178381 | POPULATION OF DAIRY COWS PRODUCING MILK WITH DESIRABLE CHARACTERISTICS AND METHODS OF MAKING AND USING SAME - The invention relates to cows capable of producing milk low in total saturated fatty acids and high in mono- and poly-unsaturated fatty acids. | 2010-07-15 |
20100178382 | Gum Manufacturing System with Loafing and Conditioning Features - Gum manufacturing machinery and method of manufacturing gum is illustrated in which a gum loafing machine generates loaves of finished gum that are then subsequently run through a gum conditioner to more uniformly set the temperature and viscosity of the gum material prior to further processing. Upon achieving the appropriate conditioning level, a further forming extruder may be used to generate a continuous gum ribbon for subsequent rolling and scoring operations. The gum conditioner may include vertically stacked conveyors that have different operational modes including a first mode that provides a serpentine path for a long residence time and a second mode that provides a cascading path that avoids or bypasses much of the length of some of the conveyors to provide a shorter residence time. The gum manufacturing machinery may be used in an adjustable manner so as to accommodate difference gum recipes for different batches of gum product. | 2010-07-15 |
20100178383 | Sparkling sake and method for producing the same - An object of the present invention is to provide an in-vessel fermentation type sparkling sake obtained by allowing mixed sake, which is prepared by mixing sake obtained by squeezing with turbid sake obtained by roughly filtering sake mash containing yeast and having fermentation activity, to generate carbon dioxide gas in a hermetically sealed vessel, wherein the sparkling sake generates fine bubbles like those from champagne, is palatable, is less turbid, and has a refreshing flavor, and to provide a method for producing the same. | 2010-07-15 |
20100178384 | METHODS AND COMPOSITIONS FOR FINING FERMENTABLE BEVERAGES - The present disclosure relates to methods and compositions for fining fermentable beverages, such as alcoholic fermentable beverages, for example, wine, beer, lager, ale, cider, perry, spirit and liqueur. The compositions herein comprise a pectin and carrageenan which are used to treat the beverage prior to fermentation. | 2010-07-15 |
20100178385 | Method for Brewing Beer - A device for brewing beer, particularly a wort pan ( | 2010-07-15 |
20100178386 | TRANS FATTY ACID FREE FAT FOR FRYING PRODUCED BY ENZYMATIC INTERESTERIFICATION AND METHOD FOR PREPARING THE SAME - The present invention can provide frying oil with the enzymatic interesterification reaction, in which trans fatty acid is not formed in the process different from the existing partially hydrogenerated oil and the frying oil contains less than 1% of trans fatty acid content and less than 27% of palmitic acid based on total fatty acid content and has solid fat content at temperature of 37.8° C. and melting point corresponding to that of partially hydrogenerated oil. Accordingly, the frying oil of the present invention is eco-friend and has lower trans fatty acid compared to the existing partially hydrogenerated oil and has higher triglyceride content without side reaction, and is also nutritionally excellent since it has lower palmitic acid content than natural palm oil which is usually used as a substitute for the existing frying oil such as partially hydrogenerated oil, and has taste corresponding to partially hydrogenerated oil. | 2010-07-15 |
20100178387 | METHOD FOR MAKING CHEESE - The present invention relates to a method for making cheese of the continental type or the cheddar type, especially reduced-fat or low-fat cheese. | 2010-07-15 |
20100178388 | BAKE-STABLE FOOD FILLING AND METHODS RELATED THERETO - A fluffy, bake-stable filling is applied to a dough component and baked to provide a food product having a crispy exterior and a creamy interior. The bake-stable filling is formed by mixing fat ingredients, such as soybean oil, and a fiber ingredients, such as oat fiber. Next, the method includes mixing more of the fiber ingredients and optional ingredients, such as cheese powder, whey protein powder, salt, yeast enhancer, and paprika. The bake-stable filling has a baked density of less than 1.875 g/cm | 2010-07-15 |
20100178389 | Consumables - Disclosed are sweetened consumables and methods of forming said sweetened consumables that comprise certain sweeteners and a compound of formula (1), wherein R | 2010-07-15 |
20100178390 | Micronutrient-Simulated Beverages - A simulated beverage simulating a natural juice, the simulated beverage comprising, per serving, at least about an equal amount of all micronutrients that are present in an amount of at least about 10% of the recommended Daily Value (“DV”) per serving of the natural juice, wherein the simulated beverage is substantially free of the natural juice and organoleptically similar to the natural juice. | 2010-07-15 |
20100178391 | FLEXIBLE PAD FOR PREPARING A BEVERAGE - The present invention provides a flexible pad for preparing a beverage comprising: a filter bag defining a storage volume; the storage volume containing a water-soluble composition or a combination or mixture of water-soluble compositions for forming a beverage; wherein the storage volume further contains one or more absorbent elements. | 2010-07-15 |
20100178392 | SINGLE-USE CAPSULE FOR PREPARING A FOOD LIQUID BY CENTRIFUGATION - A single-use capsule for preparing a food liquid from a food substance contained in the capsule by introducing water in the capsule and passing water through the substance using centrifugal forces for producing the food liquid which is centrifuged peripherally in the capsule relatively to a central axis (A) of the capsule. The capsule includes an enclosure containing a predetermined amount of food substance, and a plurality of outlet openings for enabling the food liquid to leave the enclosure under the centrifugal forces exerted in the capsule, with the outlet openings being arranged at a substantially peripheral portion of wall of the capsule. | 2010-07-15 |
20100178393 | DISPOSABLE BOTTLE FOR SUPPLY OF BEVERAGE OF SPECIAL USE FOR BABIES - Disposable bottle for supply of beverage, of special use for babies, with fastening means which externally attach the hermetic container to the body; said container is designed to hold liquid and has an upper element consisting in both a cup and a dispenser with the hermetic container detachably integrated in the interior thereof and consisting in a teat, the bottle being a feeding bottle, thereby covering the mouth of the body, characterised in that the body and upper part are disposable, for single use, and in addition having a hermetic container of reduced size which contains a dose of powder product for mixing with the liquid. | 2010-07-15 |
20100178394 | Method and Apparatus for Producing a Package or for Packaging a Food Product - A package material with a tamper evident feature and methods of manufacture thereof, are disclosed herein. The package comprises a colored primer or lacquer coating applied along a portion of a seal and further comprising a peelable sealant. When opened the peelable sealant is separated from the portion of the seal containing colored primer or lacquer and removes a section of the coating, thus providing a visual indication that the package has been opened. | 2010-07-15 |
20100178395 | METHOD FOR BAKING A CASSEROLE USING STEAM - A method of operating a household oven to bake a casserole with the introduction of steam and controlling the steam to maintain a predetermined level of humidity to control the level of browning of the casserole. | 2010-07-15 |
20100178396 | Elevated microwave heating construct - A microwave heating construct includes a platform having a plurality of peripheral edges, a plurality of elevating panels for maintaining the platform in a raised position, and a layer of microwave energy interactive material overlying at least a portion of the platform. The platform includes a movable portion defined at least partially by a line of disruption extending substantially between a pair of adjacent edges of the platform. The movable portion of the platform is adapted to pivot along the line of disruption. | 2010-07-15 |
20100178397 | FOOD THICKENING AGENT, METHOD FOR PRODUCING FOOD THICKENING AGENT - The invention provides a food and water thickener and a method for preparing the food and water thickener. The food thickener comprises pretreated mineral water, xanthan, food preservative, a first antimicrobial and chelating agent, and a sequestering agent, wherein the food thickener has a density of between 750 and 1250 grams per liter. The method for producing the thickener incorporates pretreatment of mineral water and xanthan, and specific heating steps. Also provided is method for producing thickened alcoholic beverages. The invention further provides a method for invoking a swallow response in dysphagic patients, the method comprising increasing the mass of food to between 750 mg per liter and 1500 mg per liter; and orally administering the food to dysphagic patients. | 2010-07-15 |
20100178398 | Marinating Apparatus and Process - A marination device for marinating a food item. The marination device includes a flavor injector configured to inject during a first stage marinating process liquid preparation into the food. A vacuum canister configured to pressurize to a negative pressure state during a second stage marinating process the food. The food is vacuumed to remove the air in the food, and re-pressurized to an atmospheric state in the vacuum canister to imbue the liquid preparation into the food. | 2010-07-15 |
20100178399 | Method and composition for tenderizing meat - The present application relates to an adhesive paste and a method of using an adhesive paste for tenderizing meat, comprising providing a suitable amount of meat and providing a paste having a consistency which enables it to adhere to a surface of the meat with minimal dripping or running, applying the paste to at least a lower surface of the meat and exposing the meat to a heat source for cooking and the meat is tenderized during cooking. | 2010-07-15 |
20100178400 | Method of Preparing a Whole Grain Beverage - A method for preparing a whole grain beverage via steam injection is described. More particularly, the method includes the steps of dispersing whole grain flour in a product batch to form a product mixture and subjecting the product mixture to steam injection to obtain a whole grain beverage. The whole grain beverage produced by this method has overall enhanced stability. | 2010-07-15 |
20100178401 | PACKAGED FOOD PRODUCTS - A method for the production of a stabilized packaged food product includes the steps of: filling a tray with a predetermined quantity of a food starting material; introducing the tray into a pressure vessel and conveying the tray through the pressure vessel while performing the following steps in sequence inside the pressure vessel: (i) treating the food starting material with high-temperature pressurized steam to sterilize the material, (ii) dosing the sterile food material inside the tray with a predetermined amount of sterile water; and (iii) applying a lid to the tray to seal the food product inside the tray while maintaining the tray in a sterile environment. Also provided are an apparatus for performing the method and packaged stabilized full moisture food products obtainable by the process. | 2010-07-15 |
20100178402 | Method and Apparatus for Cooking Food and Sauces - The invention relates to a variety of food, including frozen pasta sauce, packaged in a boilable pouch (“bag”) for food preparation. This invention teaches that sauce may be defrosted and heated thoroughly within a bag. By immersing the bag in boiling in water with other elements of the meal (e.g. pasta or other starch), multiple dishes may be cooked in the same pot of boiling water. The process includes packaging the frozen sauce in a vacuum-sealed boilable bag to form the packaged sauce. This present invention includes the manufacturing of frozen pasta sauce as well as to the heating of the sauce by end users (household consumers) in one pot together with pasta/starch or any other food capable of being cooked with boiling water (e.g. vegetables, meat, sausage etc.)—allowing for one pot preparation—“one pot prep.” | 2010-07-15 |
20100178403 | LOW-EMISSION DRYINGOF SUGAR BEET CHIPS - The present invention relates to an improved method of drying the extracted beet chips and means and equipment for carrying out the method, with emphasis especially on the reduction of the emission of organic carbon compounds during the chip drying stage and on the reduction of the primary energy consumption. | 2010-07-15 |
20100178404 | CAPSULE SYSTEM, DEVICE AND METHOD FOR PREPARING A FOOD LIQUID CONTAINED IN A RECEPTACLE BY CENTRIFUGATION - Method for preparing a food liquid from a food substance contained in a receptacle by passing water through the substance using centrifugal forces comprising:
| 2010-07-15 |
20100178405 | BEVERAGE BREWING SYSTEM SELECTIVELY USING ONE OR MORE CARTRIDGES - A novel beverage brewing system includes a plurality of beverage cartridge holders so that a user may selectively choose to infuse heated liquid through one or more cartridges of beverage medium (i.e., coffee grounds). One or more diverter valves may be used to achieve this. For weaker brewed coffee, a user would select a setting in which heated water passes through only one cartridge and then into a container. For stronger coffee, a setting would be chosen in which the heated water passes through both cartridges and then into the container. Alternatively, water from both cartridges could be diverted into two containers to brew weak coffee into two containers at the same time. | 2010-07-15 |
20100178406 | DEVICE AND METHOD FOR THE PREPARATION OF A FROTHY LIQUID FOR HUMAN CONSUMPTION - A device for the preparation of a frothy liquid for human consumption includes a jet forming nozzle and an inlet of a liquid flow deflecting member arranged on opposed locations with respect to a collision chamber. The jet forming emits a traversing liquid jet that traverses the collision chamber along a path and enters the inlet and passes through to the outlet of the liquid flow deflecting member. The outlet is arranged in communication with the collision chamber and is aimed at the path of the liquid jet between the jet forming nozzle and the inlet, so that in use the liquid jet emerging from the outlet collides with the traversing liquid jet between the jet forming nozzle and the inlet of the liquid flow deflecting member. The collision causes air to be mixed with the liquid thereby generating frothed liquid. | 2010-07-15 |
20100178407 | OVEN AND METHOD FOR COOKING WITH DRY HEAT AND STEAM HEAT | 2010-07-15 |
20100178408 | METHOD FOR MODULATING THE TASTE MATERIAL COMPOSITIONS CONTAINING AT LEAST ONE HIGH INTENSITY SWEETENER (HIS) - Process for modulation of a taste and/or aftertaste in foods, articles consumed for pleasure, animal feeds, sweeteners and cosmetics comprising at least one high intensity sweetener HIS by addition of a taste modulator comprising a salt preparation, and use of a salt preparation for taste modulation of foods, articles consumed for pleasure, animal feeds, sweeteners and cosmetics comprising at least one HIS. | 2010-07-15 |
20100178409 | DISTILLED LIQUORS AND SPIRITS HAVING THE FRESH AND NATURAL FRAGRANCE OF SHISO AND PROCESSES FOR PRODUCING THE SAME - Provided are liquors or spirits that compensate for the oily and grass-like smell of perillaldehyde, the primary aroma component of | 2010-07-15 |
20100178410 | Edible Foamable Compositions Comprising Clay Particles - An edible foam composition comprising fat(s), emulsifier(s), water and clay particles (such as Hectorite particles). The edible foam composition can be foamed. It is considered that the clay particles stabilize the three-phase emulsion obtained when the composition is whipped. | 2010-07-15 |
20100178411 | Agave-plant-based composition of matter and methods of use - An agave-plant-based composition of matter is disclosed that incorporates a nectar derived from the agave plant and mixed in small, discrete proportions with distilled spirits, where the distilled spirits are mostly comprised of the product of the fermentation and distillation of the juice from the core of one or more agave plants. | 2010-07-15 |
20100178412 | PRESERVED OLIVE PASTE - The present disclosure relates to a method for the preservation of olive oil that consists of freezing and optionally vacuum-packing the paste obtained from olive grinding. Furthermore, olive paste obtained through the preservation method, a procedure to obtain olive oil, and the olive oil obtained through this method, are disclosed. | 2010-07-15 |
20100178413 | Food-based Supplement Delivery System - A cookie or other food product which is designed to deliver a larger dose of cinnamon or other additive such as fruit extract or rind to a human user without significant introduction of food items detrimental to additive(s)'s expected medicinal action and without an unpleasant taste sensation. The cookie is designed to be chewed as opposed to swallowed and the flavoring of the additive(s) is intended to enhance the cookie as opposed to the flavoring being covered up or concealed by other flavorings. | 2010-07-15 |