27th week of 2011 patent applcation highlights part 35 |
Patent application number | Title | Published |
20110165528 | RECUPERATOR FOR A RADIATING TUBE BURNER - The invention relates to a heat recuperator (R) for a radiating tube burner having a burner pipe and an exhaust pipe ( | 2011-07-07 |
20110165529 | WAX AND WAX-BASED PRODUCTS - The present lipid-based wax compositions commonly include a polyol fatty acid ester component (made up of partial and/or completely esterified polyols). Generally, at least a portion of the polyol fatty acid ester has been subjected to a transesterification reaction. Lipid-based wax compositions having a melting point of about 48° C. to about 75° C. can be particularly advantageous for use in forming candles. The wax may contain other components such as mineral wax, plant wax, insect wax, and/or other components. The polyol fatty acid ester component can include triacylglycerols such as those derived from plant oils (soybean oil, palm oil, etc.). The polyol ester component may be characterized based on one or more of its physical characteristics, such as SFI-40, SFI-10, typical crystal structure, IV, melting curve, and/or other properties. | 2011-07-07 |
20110165530 | SWIRL-COUNTER-SWIRL MICROJETS FOR THERMOACOUSTIC INSTABILITY SUPPRESSION - Combustor. The combustor includes an axially symmetric tube along with means for introducing fuel and air into the tube. A swirler is disposed within the tube to impart rotation in a first direction to the air/fuel mixture. A plurality of holes downstream of the swirler are disposed around the tube and offset at an angle relative to an inward normal to the tube wall. Air is injected through the offset holes to impart rotation to the air/fuel mixture in a second direction opposite to the first direction. A combustion chamber having a diameter larger than that of the tube receives and burns the air/fuel mixture from the tube. | 2011-07-07 |
20110165531 | CARRIER POSITIONING METHOD AND CARRIER TRANSPORT SYSTEM - A carrier transport system transports a plurality of carriers by a transport conveyor into a heating furnace, advances a comb-shaped carrier stopper having a plurality of protrusions toward the carriers, moves the carriers by the transport conveyor in a transport direction to engage cutout grooves, provided respectively for the carriers, with the protrusions of the carrier stopper to thereby position the carriers at a time. The carrier transport system advances the carrier stopper toward the carriers to insert distal ends of the protrusions of the carrier stopper into insertion holes, and then determines, on the basis of a moved distance X of the carrier stopper, whether the carriers are properly positioned. | 2011-07-07 |
20110165532 | Orthodontic Device with a Self-ligating Fixing System for Orthodontic Apparatuses with a Filiform Part, Related System and Orthodontic Kit - The invention relates to an orthodontic screw with a self-ligating fixing system for orthodontic apparatuses with a filiform part comprising a head equipped with at least one longitudinal slot for the insertion of said filiform part, a threaded shank to be applied to the bone of the mouth and a stop means to reversibly block said filiform part. The stop means is a fork comprising at least two teeth and the head features at least one through hole made in one of the walls which delimit the slot, and said hole has a corresponding second through or not through hole in the opposite wall delimiting the slot and in which the axis that runs through both holes is located above the filiform part insertable in said slot. In addition, the invention regards a related system and an orthodontic kit comprising said screw. | 2011-07-07 |
20110165533 | METHOD AND SYSTEM FOR PROVIDING ALTERNATING USE ORTHODONTIC ALIGNERS - Method and system for providing a first appliance configured for positioning substantially around one or more teeth during a first portion of a recurring time period to apply one of a first predetermined force or a predetermined tooth movement on the one or more teeth, the first appliance formed of a first material, a second appliance configured for positioning substantially around the one or more teeth during a second portion of the recurring time period to apply one of a second predetermined force or a predetermined tooth movement on the one or more teeth, the second appliance formed of a second material, where at least one of the first portion and the second portion of the recurring time period is repeated at least once such that at least one of the first appliance or the second appliance is positioned again substantially around the one or more teeth during the respective first or second portion of the recurring time period are provided | 2011-07-07 |
20110165534 | SYSTEM AND METHOD FOR DETECTION OF DENTAL TARTAR - A dental tartar detection system ( | 2011-07-07 |
20110165535 | HANDPIECE FINGER SWITCH FOR ACTUATION OF HANDHELD MEDICAL INSTRUMENTATION - A handpiece for a medical instrumentation device is formed with manually deformable ribs on an outer sleeve. The ribs align with conductive surfaces inside the handpiece that make contact with an internal flexible electronic circuit to activate the device when force is applied to the ribs. Removing the force deactivates the device. | 2011-07-07 |
20110165536 | ALVEOLAR RIDGE AUGMENTATION - Apparatus is provided for use with a gingival periosteum lining a bone. The apparatus comprises a periosteal mesher, which comprises a mesher surface, and a plurality of cutting elements distributed over the mesher surface, which are configured to cut the gingival periosteum to increase flexibility thereof. Other embodiments are also described. | 2011-07-07 |
20110165537 | DENTAL OBTURATION SYSTEM - A dental obturation system, which is configured such that a power terminal unit is installed between a rotary unit and a cartridge unit such that a heating unit can heat a filling material and a needle member, mounted to the front end of a main body having a battery therein, can be rotated while applying the heated filling material to a root canal, so that an operator can easily and conveniently administer dental treatment without changing his/her posture or the orientation of the main body according to the location of a decayed tooth of a patient. | 2011-07-07 |
20110165538 | Apparatus and Method of Irregular Bone Defect Detection of Dental Implant - A non-contact apparatus and method detect irregular bone defects around a dental implant. Structural resonance frequency is produced and received to recognize a quality, a direction and a depth of an irregular bone defect. Thus, an interfacial osseointegration can be evaluated, and the present invention is of great help to assess osseointegration and diagnosis interfacial bone defects after the dental surgery. | 2011-07-07 |
20110165539 | METHOD AND COMPOSITION FOR ADHERING TO TOOTH STRUCTURE - A dental adhesive composition has an adhesive component and an activator component. The adhesive composition has a volatile organic solvent component, one or more polymerizable (meth)acrylate compounds optionally containing fillers, and a polymerization photoinitiator. The adhesive component may also be a substantially homogeneous mixture of one or more polymerizable (meth)acrylate compounds and an effective amount of a photoinitiator, without a solvent. The activator component includes an aromatic sulfinate salt and an activator component solvent. A method for adhering a restorative to a dental surface includes preparing the surface for restoration; applying a mixture of an adhesive component and an activator component to the prepared cavity, thereby forming a coated cavity surface; and, applying a direct or indirect dental restorative to the coated cavity surface. | 2011-07-07 |
20110165540 | GAMES HAVING BIOTECHNOLOGICAL CONTENT - Systems and methods for use in playing biotic games having a biologically active material as a component. Various games that provide for one or more human players to interact with biologically active materials are disclosed. The game apparatus includes a replaceable cartridge having a chamber in which a biologically active component such as a single-celled organism or a biologically active compound is contained. A stimulus controller accepts instructions from a human user and provides a stimulus to the biologically active component. A response receiver accepts a signal indicative of a response of the biologically active component. A display is provided to display to the user information indicative of the response of the biologically active component, and a game score. A computer-based game controller includes a set of pre-defined rules of play that define a game and that comprise pre-defined rules of scoring for the game. | 2011-07-07 |
20110165541 | Reviewing a word in the playback of audio data - The present invention relates to reviewing and learning word contents of an audio file using a playback apparatus. The apparatus comprises of an audio playing means for playing the digital formatted audio file, an interrupt means for a user interrupt, and a processing means for implementing the methods of the present invention. The methods and apparatus, according to the present invention, allow the user to review and learn a word in the playback of the recorded audio file. | 2011-07-07 |
20110165542 | MULTI-PARAMETER, CUSTOMIZABLE SIMULATION BUILDING SYSTEM FOR CLINICAL SCENARIOS FOR EDUCATING AND TRAINING NURSES AND OTHER HEALTH CARE PROFESSIONALS - The present invention provides a new and unique technique for providing simulation-based education tools and strategies, including for building a simulation program, such as a simulation program for educating and training nurses and other health care professionals. The simulation technique features a simulation module having one or more database and simulation scenario building modules. The database module is configured to receive inputs or instructions containing information about a selection of one or more simulation parameters stored therein, chosen by a simulation builder, including faculty, instructors or clinical educators, and based on some combination of personal preferences and specific teaching or learning objectives for building a customized simulation for educating and training nurses and other health care professionals. The database module is also configured to provide information about the selection of one or more simulation parameters. The simulation scenario building module is configured to receive the information about the selection of one or more simulation parameters, and to provide simulation scenario building signaling containing information about one or more customized simulation scenarios built for the customized simulation for educating and training nurses and other health care professionals based at least partly on the selection of the one or more simulation parameters contained in the signaling. | 2011-07-07 |
20110165543 | DIAPER WITH GRAPHIC ILLUSTRATION/TEXT/IMAGE DIRECTED TO PARENTS/CAREGIVERS BASED ON THE DEVELOPMENTAL STAGE OF THE INFANT, TODDLER OR CHILD - At the beginning of life, parent-infant interactions are the building blocks of the baby's brain and socio-emotional and cognitive development. Eye contact, touch, facial expressions, and verbal communications are essential ingredients in these interactions. One of the most prominent activities a parent/caregiver is involved in during the first year of life is diaper changing. For a newborn, the frequency of diaper changing can reach 10-12 times a day. Diaper changing brings the opportunity for this parent-child interaction to take place. The present invention uses diapers as a medium and/or tool to deliver educations and developmental images. Information and/or written and/or visual messages and tips to the parents/caregivers of infants, toddlers and children. | 2011-07-07 |
20110165544 | ACTIVITY DATA PRESENTING APPARATUS, ACTIVITY DATA PRESENTING METHOD AND RECORDING MEDIUM - An activity data presenting apparatus includes an activity information obtaining unit that obtains activity data representing a human activity, a personality data obtaining unit that obtains personality data representing the personality of a person to whom information is presented, a presenting data selecting unit that selects, on the basis of the person to whom the information is presented and of the personality data of that person, data to be presented among the activity data, a display method selecting unit that selects a display method of displaying the data to be presented corresponding to each piece of the personality data, an activity data processing unit that processes the activity data in accordance with the display method selected by the display method selecting unit, an activity data display unit that displays the activity data processed by the activity data processing unit, and a display unit. | 2011-07-07 |
20110165545 | FREE FALL SIMULATOR - A free fall simulator includes a self-contained air circuit and a hover chamber in which persons can hover as a result of an air stream directed vertically upward. A lower opening is located at a lower end of the hover chamber and an upper opening is located at an upper end of the hover chamber. A substantially closed air guide channel includes at least one fan. The channel connects the lower opening and the upper opening of the hover chamber. At least one air inlet opening and at least one air outlet opening allow for exchanging air within the air guide channel. The simulator includes redirecting lamellae which redirect an air stream within the air guide channel in corner areas or areas of high curvature, wherein at least one air outlet opening is disposed within the redirecting lamellae. | 2011-07-07 |
20110165546 | Heart Compression Simulation Device - A heart compression simulation device featuring a base; a resistance means disposed on the base; and an actuator operatively connected to the resistance means. The actuator can move between at least a starting position wherein the actuator is positioned at a starting position above the base and an end position wherein the actuator is pushed down near or contacting the base. The actuator is biased in the starting position caused by the resistance means. A tear effect providing mechanism provides resistance when moving the actuator from the starting position to the end position a first time. A lock-out mechanism is adapted to disengage the tear effect providing mechanism after the actuator has been moved from the starting position to the end position such that subsequent movements of the actuator between the starting position and the end position are not hindered by the tear effect providing mechanism. | 2011-07-07 |
20110165547 | MEDICAL PROCEDURES TRAINING MODEL - A training model for use in training to perform a medical procedure which is invasive of a skull, such as the insertion of an external ventricular drain or the evacuation of a subdural hematoma. The training model may comprise a base component defining a training component receptacle and a training component for mounting in the training component receptacle and comprising a skull section. Alternately, the training model may comprise the skull section or the training component in isolation. The skull section comprises an outer skull layer, a middle skull layer and an inner skull layer. The outer skull layer is constructed of an outer skull material which simulates osseous tissue when penetrated. The middle skull layer is constructed of a middle skull material which simulates marrow tissue when penetrated. The inner skull layer is constructed of an inner skull material which simulates osseous tissue when penetrated. | 2011-07-07 |
20110165548 | Anatomical model - An anatomical model comprising:
| 2011-07-07 |
20110165549 | CHILDREN'S STORY AUDIO/VIDEO PLAYING DEVICE - A children's story audio/video playing device includes a playing device body having a main board, a display device, a speaker, an audio receiver, a user operating device, at least one connector and power supply, and the main board includes a central processing unit, a display engine, an audio processing unit, a general purpose I/O; a USB host, a memory card controller, a power management controller, a network controller, a direct memory access unit, a program storage unit, a real time clock unit, and a memory controller, such that the children's story audio/video playing device can play words, pictures, animation images and sounds and allow users to record the played audio content. | 2011-07-07 |
20110165550 | Management system for online test assessment and method thereof - The present disclosure relates to an online test assessment management system and method thereof. The system includes a learner-information database to store login information, personal information, and learning level information of a learner; an item pool database to store questions for an online test and outputting the questions on an online test examination screen during the online test; an online test unit to perform the online test through the online test examination screen and to collect data about a sequence of inputting answers by a learner with regard to questions output for the online test, the number of clicks for changing selected answers, and a reaction time taken in inputting a certain answer after a learner selects the certain answer; and a reaction pattern analysis unit to analyze a learner's online test data collected by the online test unit, and to assess, diagnose and electronically report learner's learning level, learning ability and examination behavior to a learner or teacher terminal. | 2011-07-07 |
20110165551 | DEVICE AND SYSTEM FOR ASSISTING IN USING EQUIPMENT - On the basis of both screen transition data showing a correspondence between data showing whether a screen transition among operation screens is enabled or disabled and screen identifiers each identifying one of the operation screens, and associated data showing a correspondence between a manual item identifier and a screen identifier identifying an operation screen for enabling an operation based on an operation item specified by the manual item identifier to be performed, an information-to-be-presented deriving unit derives an operation screen corresponding to a manual item identifier acquired by a browsing detecting unit | 2011-07-07 |
20110165552 | Reading menu folder (RMF) system - aka the reading menu folder - Exemplary embodiments of a reading menu folder system is provided. The reading menu folder system comprises a front cover, a back cover having a reading assignment log, and a plurality of folders. Each folder is associated with a literary genre or literary genre sub-category and configured to hold a book associated with the literary genre or literary genre sub-category. The reading menu folder system is arranged to be customized for a reader based on age, curriculum, interests. | 2011-07-07 |
20110165553 | VITRIFIED COMPOSITION WHICH PRESERVES BIOLOGICAL MATERIALS - The present invention relates to a method for preserving biological material comprising the steps of: providing a vitrification solution comprised of the biological material and a vitrification agent where the solution has a temperature in the range from 0.1° C. to 17.9° C.; microwaving the vitrification solution for a first period of time; allowing the vitrification solution to rest for a second period of time; repeating steps b and c until the vitrification solution enters into a glassy state. | 2011-07-07 |
20110165554 | METHODS AND BIOMARKERS FOR DIAGNOSING AND MONITORING PSYCHOTIC DISORDERS - A method of diagnosing or monitoring a psychotic disorder, or predisposition thereto, comprises measuring, in a sample taken from a subject, the levels of one or more peptide biomarkers listed herein. | 2011-07-07 |
20110165555 | Capillary-Column-Based Bioseparator/Bioreactor with an Optical/Electrochemical Detector for Detection of Microbial Pathogens - The present invention is directed to satisfying the need to detect microbial contamination of food products. The described bioseparator/bioreactor coupled with an optical/electrochemical biosensor was able to specifically detect | 2011-07-07 |
20110165556 | SYSTEM AND METHOD FOR DETECTION OF HIV TROPISM VARIANTS - An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species, wherein each first amplicon comprises a plurality of amplified copies and is amplified with a pair of nucleic acid primers that define a locus of the first amplicon; clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons wherein a plurality of the second amplicons comprise an immobilized population of substantially identical copies from one of the amplified copies of first amplicons; determining a nucleic acid sequence composition of the substantially identical copies from at least 100 of the immobilized populations in parallel on a single substrate; and detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic acid sequence composition of the at least 100 immobilized populations; and correlating the detected sequence variants with variation associated with HIV tropism. | 2011-07-07 |
20110165557 | APPARATUS AND METHOD FOR DETECTING BIOMOLECULES - Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the substrate, a microfluid supplier selectively supplying one of a reference buffer solution of low ionic concentration and a reaction solution of high ionic concentration containing target molecules, to the channel region of the FET to which the probe molecules are fixed, and a biomolecule detector detecting the target molecules by measuring a first current value of the channel region of the FET, and a second current value of the channel region of the FET to which the target molecules and the probe molecules that bind to each other in the reaction solution of high ionic concentration are fixed. | 2011-07-07 |
20110165558 | METHOD FOR IDENTIFYING INDIVIDUAL VIRUSES IN A SAMPLE - Individual viruses in any type of sample are identified quickly, unambiguously and reliably, and with the least possible preparation-related and technology-related expenditure, without necessitating immobilization using antibodies and without requiring an indication or at least a suspicion of potentially present viruses. This is accomplished by scanning the height profile of the sample, from which scanning sites suspected of containing viruses are selected, exposing those cites to monochromatic excitation light and spectroscopically analyzing the resulting Raman scattered light. | 2011-07-07 |
20110165559 | Lateral flow based methods and assays for rapid and inexpensive diagnostic tests - The invention provides reagents and methods for lateral flow assays and quantitative capture or determination of components, including cells, in a sample. In one aspect, reagents and methods for diagnostic assay are provided. In one embodiment an assay for determining T cell numbers, particularly a CD2+ CD4+ T cell assay is provided. A manufacturing method for producing rapid diagnostic assays in a decentralized manner is also described. The method generates net economic advantages over conventional diagnostic manufacturing practices. | 2011-07-07 |
20110165560 | METHODS AND COMPOSITIONS FOR SCREENING FOR INDIVIDUALS AT RISK FOR SUCCINATE DEHYDROGENASE-RELATED DISEASE CONDITIONS - The present invention provides methods, compositions, and kits associated with succinate dehydrogenase-related disease conditions. In one aspect of the present invention, a method for screening a test subject to determine risk for developing a succinate dehydrogenase-related disease condition is provided. Such a method can include obtaining a biological sample from the test subject and identifying a mutation in gene hSDH5 from the biological sample of the test subject, wherein the mutation effectuates a decreased level of succinate dehydrogenase flavination in the test subject as compared to a level of succinate dehydrogenase flavination in a normal subject. In one aspect, the mutation is at hSDH5 Gly78 of gene hSDH5. In another aspect, the mutation is equivalent to an hSDH5 Gly78Arg substitution of gene hSDH5. | 2011-07-07 |
20110165561 | DIRECT AND CONTINUOUS ROOT ALONE OR ROOT/SHOOT PRODUCTION FROM TRANSGENIC EVENTS DERIVED FROM GREEN REGENERATIVE TISSUES AND ITS APPLICATIONS - The present invention provides assays and methods for efficiently testing a polynucleotide of interest for a phenotype in a root. In some embodiments, the assays and methods include regenerating green tissue that is transgenic for at least one polynucleotide of interest into one or more transgenic plantlets that have at least one transgenic root. Further provided are methods of making a root assay by contacting green tissue with a first rooting medium to produce a plantlet and a plurality of roots. Additionally provided are methods of assaying for insecticidal activity on a live root. Accordingly provided herein is a substantially contamination-free, root bioassay. Further provided are methods of identifying a promoter having activity in a root. | 2011-07-07 |
20110165562 | METHOD FOR SEPARATING AN ANALYTE FROM A SAMPLE - An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path. | 2011-07-07 |
20110165563 | DESIGN, SYNTHESIS AND USE OF SYNTHETIC NUCLEOTIDES COMPRISING CHARGE MASS TAGS - Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced. | 2011-07-07 |
20110165564 | SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES - A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl- | 2011-07-07 |
20110165565 | COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE EXTRACTION AND METHYLATION DETECTION - The present invention features methods and compositions for methylation detection, as well as a novel method for polynucleotide extraction and sodium bisulfite treatment. | 2011-07-07 |
20110165566 | METHODS OF OPTIMIZING TREATMENT OF BREAST CANCER - Breast cancer treatment can be optimized by determining the level of expression of genes in a breast sample from a human to identify a human with an increased likelihood of recurrence of the breast cancer that would potentially benefit from a therapy to decrease the likelihood of recurrence of the breast cancer. | 2011-07-07 |
20110165567 | ABERRANT METHYLATION OF C6Orf150 DNA SEQUENCES IN HUMAN COLORECTAL CANCER - This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia. | 2011-07-07 |
20110165568 | SEQUENCES OF E.COLI 055:H7 GENOME - Disclosed is the genomic sequence for | 2011-07-07 |
20110165569 | COMBINATORIAL DNA TAGGANTS AND METHODS OF PREPARATION AND USE THEREOF - DNA taggants in which the nucleotide sequences are defined according to combinatorial mathematical principles. Methods of defining nucleotide sequences of the combinatorial DNA taggants, and using such taggants for authentication and tracking and tracing an object or process are also disclosed. | 2011-07-07 |
20110165570 | METHOD OF EFFECTING DE-DIFFERENTIATION OF A CELL - The invention provides a method of effecting de-differentiation of an at least partially differentiated cell or of maintaining pluripotency and/or self-renewing characteristics of an undifferentiated cell. The method comprises increasing the amount or the activity of an Err protein, or a functional fragment thereof, in the cell. | 2011-07-07 |
20110165571 | HERBICIDE TOLERANT RICE PLANTS AND METHODS FOR IDENTIFYING SAME - The invention provides specific transgenic rice plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the rice genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples. | 2011-07-07 |
20110165572 | METHODS AND KITS FOR NUCLEIC ACID SEQUENCING - Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules. | 2011-07-07 |
20110165573 | METHOD TO DETECT PROSTATE CANCER IN A SAMPLE - The present invention relates to prostate cancer. More specifically, the present invention relates to a method to detect prostate cancer in a patient sample by detecting the RNA encoded by the gene PCA3. More particularly the present invention relates to a method for determining a predisposition, or presence of prostate cancer in a patient comprising: (a) contacting a biological sample of a patient with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting in the biological sample an amount of PCA3 and second prostate specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and therefrom determining the presence or absence of prostate cancer in the biological sample. The present invention further relates to diagnostic kits for the detection of prostate cancer or the risk of developing same in a patient comprising: (a) at least one container means having disposed therein at least one oligonucleotide probe or primer that hybridizes to one a PCA3 nucleic acid or complement thereof; (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid or complement thereof; and (c) reagents enabling a detection of PCA3 and of the second prostate specific nucleic acid when PCA3 or second prostate-specific nucleic acid sequence is present. | 2011-07-07 |
20110165574 | METHOD FOR AMPLIFYING SPECIFIC NUCLEIC ACID FRAGMENTS WITH THE AID OF A RECURRENT CHAIN REACTION - The invention relates to a method for amplifying specific nucleic acid fragments with the aid of two variants of a recurrent chain reaction 2/2 and 2/1, in which instead of the typical primers used in a standard PCR, the primers in the form of tandem repeated sequences of a singular (basic) primer, in which repeats are disposed according to a “head-to-tail” type, and which consist of two or more such elements, are used as forward and/or reverse primers. As a result of amplification, the length of an amplicon is increased with each cycle by the length of the singular primer, thereby increasing, over a cycle, annealing places in the amplicon, providing the growth of the coefficient of replication and bringing about the accelerated accumulation of the amplicons, the number of which is greater by several orders than said number in a PCR. The use of a thermostable Vent-type DNA polymerase exhibiting DNA strand displacement activity results in a double-stranded amplicon being produced in each cycle and results in the single-stranded DNA which are formed before the annealed primers and are displaced by said polymerase, the number of such amplicons in the form of single-stranded DNA increasing in each cycle. The inventive method can be recommended for sequencing DNA, for DNA diagnostics in medicine, veterinary science, in sanitary and epidemiological studies, in the food industry for detecting food products made from genetically modified organisms, for testing raw material quality, for detecting the agents of dangerous infections, including potential bio-terrorist attacks, and in criminalistics for identifying criminals. | 2011-07-07 |
20110165575 | METHOD FOR SYNTHESIZING DNA STRAND - The present invention provides a primer extension reaction method, such as a PCR method, for structure-independent amplification of DNA containing CG-rich repeat sequences wherein in the extension step the temperature fluctuates between a first extension temperature and a second extension temperature. The present invention also provides methods for diagnosing disorders. The present invention also provides a thermal cycler programmed to perform the method of the invention. | 2011-07-07 |
20110165576 | MOLECULAR DIAGNOSTIC KIT FOR THE DETECTION OF VIRULENT STRAINS OF HELICOBACTER PYLORI - A kit in the form of a product and a method is able to detect simultaneously four genes of | 2011-07-07 |
20110165577 | SELECTION OF COLORECTAL CANCER PATIENTS FOR NEO-ADJUVANT AND ADJUVENT SYSTEMIC ANTI-CANCER TREATMENT - The present invention relates to method for determining whether a gastrointestinal cancer patient is likely to experience a disease recurrence, said method comprising steps of determining concentration of TIMP-1 in a pre-operative plasma sample of said patient, and determining the concentration of CEA in a pre-operative body fluid sample of said patient, and evaluate whether the patient as likely to experience a disease recurrence. The present invention further provides kits for application of said methods. | 2011-07-07 |
20110165578 | METHODS FOR DETECTING AND QUANTIFYING OVERSULFATED GLYCOSAMINOGLYCANS - The invention relates to novel methods for detecting and/or quantifying oversulfated or persulfated glycosaminoglycans based on inhibition of nucleic acid polymerases. The methods can be utilized to detect and quantify oversulfated or persulfated glycosaminoglycans in pharmaceutical preparations, such as heparin preparations or therapeutic medical devices. When used to detect or quantify oversulfated glycosaminoglycans in heparin containing solutions, the samples are prepared by treatment with heparinases to degrade the heparin. Titration of the inhibition of the activity of the polymerases allows quantitation of the oversulfated glycosaminoglycans in the sample. | 2011-07-07 |
20110165579 | PCR-RIBOTYPING OF C. DIFFICILE - Described is a method of polymerase chain reaction (PCR) analysis of polymorphisms in the 16s-23s intergenic spacer region of | 2011-07-07 |
20110165580 | Response Element Regions - Response element regions, DNA constructs comprising response element regions, host cells comprising response element regions, and methods of using response element regions are provided. | 2011-07-07 |
20110165581 | METHODS FOR SCREENING FOR COMPOUNDS FOR TREATING CANCER - The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1. | 2011-07-07 |
20110165582 | MOLECULAR METHOD FOR DIAGNOSIS OF COLON CANCER - Methods for diagnosing or detecting cancerous colon tissue. A panel of 17 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal human colon tissue and the underexpression of the rest of these marker genes are indicative of cancerous colon tissue. By using these 17 marker genes as a diagnostic tool, smaller tissue samples, such as those obtained by core needle biopsies, from patient stool samples, or from blood samples can be used. | 2011-07-07 |
20110165583 | VECTOR FOR IDENTIFICATION, SELECTION AND EXPRESSION OF RECOMBINANTS - A modified vector comprising a reporter gene having a STOP codon upstream of the multiple cloning site of the vector which is characterized in that the recombinant clones show fluoresce or show color in presence of inducer. A method for identification and selection of recombinant clones comprising the modified vector wherein the recombinant clones florescence or show color in a suitable suppressor strain of the STOP codon associated with the gene of interest. A method of preparation of recombinant clone comprising gene of interest and modified vector comprising amplification of gene of interest using specific primers containing STOP codon different from STOP codon used with reporter gene; cloning the amplified gene of interest in the modified vector; transformation of cloned modified vector in the STOP codon suppressor host cell wherein the STOP codon suppressor host cell is specific for STOP codon used with the gene of interest wherein the recombinant clones either fluorescence or show color depending upon the reporter gene used. | 2011-07-07 |
20110165584 | Variable Lymphocyte Receptors, Related Polypeptides and Nucleic Acids and Uses Thereof - Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). | 2011-07-07 |
20110165585 | MULTI-SPECIES POLYNUCLEOTIDE CONTROL SEQUENCES - The present invention relates to polynucleotide sequences which enable a polynucleotide control sequence, such as a promoter, to direct expression in a wide range of industrially relevant species, both prokaryotes and eukaryotes. When the polynucleotide sequences of the invention are applied in combination with selection marker genes it is possible to perform selectable cloning in a laboratory host and use the same construct in the final host | 2011-07-07 |
20110165586 | Detection Method of Bio-Chemical Material Using Surface-Enhanced Raman Scattering - Provided is a detection method of a biochemical material using surface-enhanced Raman scattering in order to detect the existence of a biochemical material in a target subject or its content therein, more particularly a detection method of a biochemical material facilitating multiplex detection with high-sensitivity, high-reproducibility, high-reliability, and high-precision owing to multiple hot spots formed on the nanowire surface of a single crystal body by the bond of multiple nanoparticles which are physically separated from each other. | 2011-07-07 |
20110165587 | Method for live-cell activity assay - Provided are technologies capable of direct measurement of activity of a bioactive substance in cell using nanowires, more particularly, a method for measuring intracellular activity of a bioactive substance using a nanowire support to which cells are immobilized and a nanowire support to which target substances for the subject bioactive substance are immobilized, and a chip for measuring intracellular activity of a bioactive substance including nanowires to which cells are immobilized and nanowires to which a target substance for the subject bioactive substance is immobilized. | 2011-07-07 |
20110165588 | METHOD FOR QUANTIFYING PHOSPHOKINASE ACTIVITY ON PROTEINS - The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine or tyrosine residue, subjecting that protein (non-phosphorylated) to reaction mixture containing all reagents, including phosphokinase which allow the creation of a phosphorylated form of protein. The phosphorylated protein is measured by contacting it with an antibody specific for the phosphorylation site(s). The invention includes antibodies useful in practicing the methods of the invention. The invention particularly relates to all proteins modified by phosphorylation and dephosphorylation as illustrated by Tau, Rb and EGFR proteins and antibodies specific for the site of phosphorylation of the Tau, Rb or EGFR proteins. | 2011-07-07 |
20110165589 | DEVICE AND METHOD FOR SEPARATING AND ANALYZING BLOOD - The invention provides a device for detecting FABP in a blood sample from a patient, methods for analyzing blood on the presence of FABP, as well as methods and kits for the detection of FABP in a blood sample from a patient. | 2011-07-07 |
20110165590 | Vaccine Protection Assay - The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular | 2011-07-07 |
20110165591 | USE OF BIGLYCAN IN THE ASSESSMENT OF HEART FAILURE - The invention relates to a method for assessing heart failure in vitro and involves the steps of measuring in a sample the concentration of the marker biglycan, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for biglycan and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of biglycan as a marker protein in the assessment of heart failure, a marker combination comprising biglycan and a kit for measuring biglycan. | 2011-07-07 |
20110165592 | ANTIBODIES AGAINST HUMAN EPO RECEPTOR - An antibody binding to human EPO receptor, characterized in specifically binding EPO receptor fragment LDKWLLPRNPPSEDLPGPGGSVDIV (SEQ ID NO:1), CSSALASKPSPEGASAASFEY (SEQ ID NO:2), or GGLSDGPYSNPYENSLIPAAEP (SEQ ID NO:3) is useful for the analysis of EPO receptor in human tissue. | 2011-07-07 |
20110165593 | Mutants of 06-Alkylguanine-DNA Alkyltransferase - The invention relates to AGT mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction; (b) localisation of the expressed protein in eukaryotic cells that is no longer restricted to the nucleus; (c) improved expression yield as soluble protein and improved stability in various hosts; (d) improved stability under oxidising conditions; (e) improved stability within cells after reaction with a substrate; (f) improved stability outside cells before and after reaction with a substrate; (g) improved in vitro solubility; (h) improved reactivity against O | 2011-07-07 |
20110165594 | SYSTEMIC MARKERS FOR ASTHMA AND ANALOGOUS DISEASES - Provided herein are diagnostic and prognostic methods, diagnostic and prognositic markers, and methods for evaluating anti-inflammatory agents or drugs in subjects with asthma and/or an analogous disease associated with high oxidative and nitrative stress at the disease site. In certain embodiments, the methods comprise a step of assaying for decreased levels of superoxide dismutase activity in the blood, serum, or plasma of the subject. In certain embodiments, the methods comprise a step of assaying for elevated levels of one or more oxidatively-modified SOD isoforms or species in the blood, serum or plasma of the subject. Also provided are diagnostic kits for use in the present invention. In certain embodiments, such kits comprise at least one binding reagent that specifically binds to at least one oxidatively-modified SOD species. | 2011-07-07 |
20110165595 | APPARATUS AND METHODS FOR PROCESSING A WHOLE BLOOD SAMPLE - The present invention provides a device and method for heating a whole blood sample for use in an assay, comprising irradiating said whole blood sample with monochromatic visible light of between 380 nm and 740 nm to raise the temperature of said whole blood sample to a target temperature between about 35° C. and 40 ° C. An apparatus for heating whole blood samples stored in a cartridge is further described comprising a housing assembly disposed to receive the cartridge one or more visible light optical emitters disposed in the housing apparatus and configured to selectively illuminate a staging area of the cartridge a temperature sensor disposed in the housing apparatus and configured to sense a temperature of the cartridge and a control circuit coupled to the temperature sensor and the array of visible light optical emitters so as to control a heating profile of the whole blood sample. | 2011-07-07 |
20110165596 | Use of Carbamoyl Phosphate Synthetase 1 (Cps) as a Humoral Biomarker For the Diagnosis of Tumour Diseases and Chronic Inflammatory Intestinal Diseases - The invention relates to the use of carbamoyl synthetase 1 (CPS 1) as a humoral biomarker in in vitro methods for early diagnosis and detection, progress prognosis, the evaluation of the severity, and the progress evaluation of tumor diseases and chronic inflammatory intestinal diseases. | 2011-07-07 |
20110165597 | METHOD FOR THE SCREENING OF CONSERVED SECRETED PROTEINS - Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use. | 2011-07-07 |
20110165598 | METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE - Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by Aβ oligomers. | 2011-07-07 |
20110165599 | MONOCLONAL ANTIBODY THERAPY FOR PANCREAS CANCER - The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer. | 2011-07-07 |
20110165600 | DIAGNOSIS METHOD AND DIAGNOSIS KIT FOR DERMATOMYOSITIS - An object of the present invention is to identify an antigen corresponding to anti-CADM-140 antibody, produce a recombinant protein, and establish an assay system by ELISA or the like. The present invention provides a kit for diagnosing dermatomyositis containing an MDA5 protein shown in SEQ ID NO: 4 or a fragment thereof that is recognized by anti-CADM-140 antibody. | 2011-07-07 |
20110165601 | ASSAY SYSTEM - The present invention relates to materials and methods for performing assays directed to monitoring activity and function of intracellular components, such as proteins associated with organelles and other intracellular structures. In particular, the invention relates to permeabilised cell preparations and their use in studying activity of intracellular components, in particular for studying sarcoplasmic reticulum function. | 2011-07-07 |
20110165602 | EMISSION RATIOMETRIC INDICATORS OF PHOSPHOINOSITIDES - Emission ratiometric indicators of phosphoinositides comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a “pseudoligand” containing acidic amino acid residues, which is sandwiched between resonance energy transfer (RET) pairs, such as cyan and yellow mutants of GFP (a FRET pair). Such indicators can be used, inter alia, to monitor spatiotemporal dynamics of phosphoinositides and in high throughput assays for inhibitors of PI3K, including drug screening assays. | 2011-07-07 |
20110165603 | SMALL MOLECULE FLUORESCENT SENSORS FOR DETECTION OF POST-TRANSLATIONALMODIFICATIONS AND PROTEIN INTERACTIONS IN BIOASSAYS - The present invention relates to novel compounds which are capable as acting as fluorescent sensors or which are precursors for these and for the use of these for the assay of biological processes such as posttranslational modifications of biological molecules such as phosphorylation, de-phosphorylation, proteolytic cleavage, phosphodiesterase mediated hydrolysis of cyclic nucleotides, methylation, acetylation of proteins peptides, DNA, lipids and the detection of biomolecule interactions (e.g., protein-protein interactions). A small molecule sensor is described which can associate to phosphorylated biological targets via metal ion—phosphate association. The association event can be monitored as fluorescence quench, sensitized emission, fluorescence polarization or a combination thereof. The sensor is useful for determining enzyme | 2011-07-07 |
20110165604 | REACTION MEDIUM FOR METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) BACTERIA - A reaction medium for detecting and/or identifying Methicillin-resistant | 2011-07-07 |
20110165605 | METHOD FOR DESIGNING MUTANT ENZYME, METHOD FOR PREPARING MUTANT ENZYME, AND MUTANT ENZYME - An object is to provide a novel method of improving an enzyme capable of deamidating a protein. A mutant enzyme is designed by the following steps: (1) specifying one or more amino acids selected from the following group, namely, consisting of an amino acid corresponding to the amino acid at position 35, an amino acid corresponding to the amino acid at position 38, an amino acid corresponding to the amino acid at position 39, an amino acid corresponding to the amino acid at position 40, an amino acid corresponding to the amino acid at position 41, an amino acid corresponding to the amino acid at position 42, an amino acid corresponding to the amino acid at position 43, an amino acid corresponding to the amino acid at position 45, an amino acid corresponding to the amino acid at position 46, an amino acid corresponding to the amino acid at position 49, an amino acid corresponding to the amino acid at position 79, an amino acid corresponding to the amino acid at position 80, an amino acid corresponding to the amino acid at position 81, an amino acid corresponding to the amino acid at position 82, an amino acid corresponding to the amino acid at position 83, an amino acid corresponding to the amino acid at position 84, an amino acid corresponding to the amino acid at position 103, an amino acid corresponding to the amino acid at position 104, an amino acid corresponding to the amino acid at position 105, an amino acid corresponding to the amino acid at position 106, an amino acid corresponding to the amino acid at position 117, an amino acid corresponding to the amino acid at position 142, an amino acid corresponding to the amino acid at position 143, an amino acid corresponding to the amino acid at position 146, an amino acid corresponding to the amino acid at position 166, and an amino acid corresponding to the amino acid at position 185 in an amino acid sequence set forth in SEQ ID NO: 2, in a protein deamidase (an enzyme to be mutated); and (2) constructing an amino acid sequence having substitution of the amino acid(s) specified in the step (1) by another amino acid(s) or having deletion of the amino acid(s) specified in the step (1) using the amino acid sequence for an enzyme to be mutated as a base sequence. | 2011-07-07 |
20110165606 | METHODS FOR MODIFYING, ISOLATING, DETECTING, VISUALIZING, AND QUANTIFYING CITRULLINATED AND/OR HOMOCITRULLINATED PEPTIDES, POLYPEPTIDES AND PROTEINS - The present invention relates to methods and compositions for modifying, isolating, detecting, visualizing, and quantifying citrulline and/or homocitrulline-containing peptides, polypeptides, and proteins using mono- and disubstituted glyoxal derivatives. The invention also provides kits for modifying, isolating, detecting, visualizing, and quantifying the relative amounts of citrulline and/or homocitrulline-containing peptides, polypeptides, or proteins in solutions or samples. | 2011-07-07 |
20110165607 | METHOD FOR EVALUATING STATUS OF SKIN BARRIER FUNCTION OF NATURAL MOISTURIZING FACTOR USING BLEOMYCIN HYDROLASE ACTIVITY AS INDICATOR - The present invention provides a method for evaluating the status of the skin barrier function of natural moisturizing factor (NMF) using the activity of bleomycin hydrolase in skin tissue as an indicator. | 2011-07-07 |
20110165608 | BLOOD COMPONENT MEASUREMENT METHOD UTILIZING HEMOLYZED WHOLE BLOOD, AND KIT FOR THE METHOD - The invention is a method for determining the concentration of an analyte in whole blood, wherein the analyte is a component which is contained in the blood, is different from a component occurring only in a red blood cell, and can generate hydrogen peroxide upon the reaction with an oxidase. Whole blood is utilized in the method. The method comprises the steps of hemolyzing the whole blood and detecting hydrogen peroxide generated by the reaction between the analyte and the oxidase. The measurement method can avoid the inhibition of color development by hemoglobin and the interference with the measurement by hemoglobin. Further it can be used for biological tests that are carried out in a household, an individual doctor's clinic or at the bedside of patients without the need for any blood cell separation procedure or the like, because the measurement utilizes whole blood. | 2011-07-07 |
20110165609 | DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTIVATION OF MICROSCOPIC OBJECTS - The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy. | 2011-07-07 |
20110165610 | COMPOSITIONS, SYSTEMS, AND METHODS FOR PRESERVATION AND/OR STABILIZATION OF A CELL AND/OR MACROMOLECULE - The present disclosure relates to compositions, systems, and methods for preserving and/or stabilizing a cell (e.g., a whole cell). A cell and/or macromolecule stabilizing composition may include a chelator, a chelator enhancing component, and optionally a base (e.g., a purine base or a pyrimidine base). A cell stabilizing method may include contacting a cell with a cell and/or macromolecule stabilizing composition. A cell stabilizing system may include a container suitable for receiving a sample containing a cell and a cell and/or macromolecule stabilizing composition. A cell may be preserved and/or stabilized under ambient conditions (e.g., without refrigeration). A cell may include a protein, a nucleic acid, and/or another biomolecule marker of cell preservation and/or stabilization. A composition may be configured to preserve and/or stabilize one or more cells for analysis by flow cytometry and simultaneously preserve and/or stabilize one or more intracellular nucleic acids for molecular analysis. | 2011-07-07 |
20110165611 | DUAL MODALITY DETECTION OF APOPTOSIS - To image apoptosis in vivo, small, membrane-permeable probes comprising a caspase 3 substrate, a fluorogenic dye and a radionuclide is provided. This dual-modality probe can be cleaved by caspase upon exposure to apoptotic cells, allowing imaging of caspase 3 and 7 activities using both optical and nuclear imaging techniques. The combined use of these methods provides the opportunity for a direct correlation between in vitro and in vivo biological activities and a viable method to treat disease | 2011-07-07 |
20110165612 | NOVEL YEAST STRAINS FOR PRODUCING ALCOHOL - The present invention relates to novel stable yeast strains, to a novel method for obtaining such strains, and to a novel method for evaluating the stability of a yeast strain. The present invention also relates to the yeasts obtained from these novel stable yeast strains, and to the use thereof for producing alcohol. | 2011-07-07 |
20110165613 | STABLE CLONE CELL EXPRESSING A PRION - The invention relates to a cell clone derived from the MovS6 line, said cell clone expressing a prion protein PrP and being capable of tolerating the replication or propagation of the pathological form PrPsc of said PrP, characterized in that its titre with respect to marker for infection with a non-conventional transmissible agent (NCTA) is stable at least up to the 6 | 2011-07-07 |
20110165614 | REACTION MEDIUM FOR STAPHYLOCOCCUS AUREUS BACTERIA - A reaction medium for detecting and/or identifying | 2011-07-07 |
20110165615 | APPARATUS AND METHODS FOR AUTOMATED HANDLING AND EMBEDDING OF TISSUE SAMPLES - An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation. | 2011-07-07 |
20110165616 | METHOD AND APPARATUS FOR BIOPSY SAMPLE PROCESSING - A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned at the downstream side of the barrier, and holds fluids within the container. | 2011-07-07 |
20110165617 | Enzymatic Hydrolysis Of Pretreated Lignocellulose-Containing Material With Distillers Dried Grains - A method for producing a fermentation product from a lignocellulose-containing material comprises combining lignocellulose-containing material and distillers dried grains with or without solubles (DDG/S); pre-treating the combined ligno-cellulose-containing material and DDG/S; exposing the pre-treated combined lignocellulose-containing material and DDG/S to an effective amount of hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product. | 2011-07-07 |
20110165618 | BIOLOGICAL SYSTEMS FOR PRODUCTION OF COMMERCIALLY VALUABLE COMPOUNDS - The invention relates to systems and methods for production of compounds by yeast and other organisms. In one approach yeast engineered for production of a compound of commercial value is cultured together with a cellulosic bacteria, and the yeast uses a metabolic product produced by the bacteria as a carbon source. Methyl halides are an example of compounds that may be produced by this process. The invention also relates to production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase. In one approach the organism, halides and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non-halogenated organic molecules. | 2011-07-07 |
20110165619 | Secretion Optimized Microorganism - Proteins having a cofactor can be secreted in an improved manner in a microorganism belonging to the genus | 2011-07-07 |
20110165620 | METHOD FOR THE PRODUCTION OF PROTEINS OR PROTEIN FRAGMENTS - The present invention relates to a method for selecting a suitable expression construct from a plurality of expression constructs for optimizing the production of a protein or a fragment thereof in a host cell, a method for the production of proteins or fragment thereof using the selected expression vector, to novel human embryonic kidney cells that are deficient in N-acetyl-glucosaminyltransferase I and stably transfected with EBNA (HEK 293E GnTI′cells) that are well suitable for use in the said method, in particular for the production of proteins or protein fragments that are suitable for X-ray studies. The invention also relates to a method to produce HEK 293E GnTI′ cells and a method to confer to HEK293E GnTI′ cells, the capacity to grow in suspension and to a method to confer to HEK293E GnTI′ cells, the capacity to grow in serum free medium. The invention also relates to a kit comprising different vectors suitable for use of the above method for the production of proteins or protein fragments. | 2011-07-07 |
20110165621 | HUMANIZED ANTIBODIES - The invention relates to novel humanized antibodies derived from the conventional antibody repertoire of species in the family Camelidae. | 2011-07-07 |
20110165622 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 2011-07-07 |
20110165623 | Compositions and Methods for the High Efficiency Expression of the Transforming Growth Factor-Beta Supergene Family - Novel compositions and methods for the high efficiency production of the transforming growth factor-beta (TGFβ) supergene family of peptide growth factors are provided. | 2011-07-07 |
20110165624 | PROTEIN PURIFICATION TAGS AND USES THEREOF - The present invention relates to fusion proteins. In particular, the present invention relates to protein tags for use in protein solubilization and purification. | 2011-07-07 |
20110165625 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 2011-07-07 |
20110165626 | HIGH YIELD PRODUCTION OF SIALIC ACID (NEU5AC) BY FERMENTATION - The present invention relates to a method for producing sialic acid, comprising the step of culturing a microorganism in a culture medium, wherein said microorganism comprises heterologous genes encoding a sialic acid synthase (NeuB), a UDP-GlcNAc epimerase (NeuC), said micro-organism being devoid of a gene encoding CMP-Neu5Ac synthase (NeuA) or wherein a gene encoding CMP-Neu5Ac synt hase (NeuA) has been inactivated or deleted; and wherein endogenous genes coding for sialic acid aldolase (NanA), for ManNac kinase (NanK) and for sialic acid transporter (NanT) have been deleted or inactivated. It also relates to the above microorganism. | 2011-07-07 |
20110165627 | GENE SITE SATURATION MUTAGENESIS - A method for producing progeny polynucleotides and polypeptides by Gene Site Saturation Mutagenesis (GSSM). The method provides a set of degenerate primers corresponding to codons of a template polynucleotide, and performs polymerase elongation to produce progeny polynucleotides, which contain sequences corresponding to the degenerate primers. The progeny polynucleotides can be expressed and screened for directed evolution. | 2011-07-07 |